Gurdyal Besra

Q: What Schools Are Affiliated With Gurdyal Besra

Gurdyal Besra is affiliated with the following schools: Imperial College London, University of Oxford, Newcastle University, University of Birmingham, Colorado State University

Gurdyal Besra's AcademicInfluence.com Rankings

Gurdyal Besra

Biology

#7238

World Rank

#10131

Historical Rank

Microbiology

#385

World Rank

#437

Historical Rank

biology Degrees

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Biology

Gurdyal Besra's Degrees

Bachelors Microbiology University of Oxford
Masters Microbiology University of Oxford
PhD Microbiology University of Oxford

Why Is Gurdyal Besra Influential?

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According to Wikipedia, Gurdyal Singh Besra is Bardrick Professor of Microbial Physiology & Chemistry at the University of Birmingham. Education Besra was educated at Newcastle University where he was awarded a Bachelor of Science degree 1987 followed by a PhD for studies on the lipids of the leprosy bacillus in 1990.

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Gurdyal Besra's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis (2005) (592)
CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor (2007) (560)
The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. (1996) (457)
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection (2000) (447)
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean (2008) (426)
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response (2004) (417)
Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum (2008) (396)
A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti: characterization of an exceptional isolate from Africa. (1997) (383)
Apolipoprotein-mediated pathways of lipid antigen presentation (2005) (380)
IL-21 Is Produced by NKT Cells and Modulates NKT Cell Activation and Cytokine Production1 (2007) (376)
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. (2008) (334)
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis. (2002) (324)
Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides. (2005) (320)
Invariant natural killer T cells recognize lipid self-antigen induced by microbial danger signals (2011) (312)
Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae (2013) (295)
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue (2014) (284)
Mycolic Acid Structure Determines the Fluidity of the Mycobacterial Cell Wall* (1996) (281)
The crystal structure of human CD1d with and without α-galactosylceramide (2005) (281)
Activation of the pro-drug ethionamide is regulated in mycobacteria. (2000) (279)
Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection (2011) (276)
Biogenesis of the mycobacterial cell wall and the site of action of ethambutol (1995) (272)
The methyl-branched fortifications of Mycobacterium tuberculosis. (2002) (270)
Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. (2011) (270)
Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host–pathogen interaction (2011) (254)
Assembly of the Mycobacterial Cell Wall. (2015) (243)
NK T cells provide lipid antigen-specific cognate help for B cells (2008) (241)
Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes (2009) (240)
Thiolactomycin and Related Analogues as Novel Anti-mycobacterial Agents Targeting KasA and KasB Condensing Enzymes inMycobacterium tuberculosis * (2000) (234)
Mechanism of thioamide drug action against tuberculosis and leprosy (2007) (227)
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation (2007) (224)
A Subset of Liver NK T Cells Is Activated during Leishmania donovani Infection by CD1d-bound Lipophosphoglycan (2004) (217)
Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei (2003) (216)
A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy. (1995) (213)
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner (2011) (210)
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo (2008) (208)
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation (2007) (207)
The Mycobacterium tuberculosis FAS‐II condensing enzymes: their role in mycolic acid biosynthesis, acid‐fastness, pathogenesis and in future drug development (2007) (202)
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice (2007) (196)
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis (2002) (192)
Natural killer T cells in adipose tissue prevent insulin resistance. (2012) (191)
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis (2007) (191)
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines (2000) (187)
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. (2000) (187)
A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum (2003) (185)
PPARγ controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells (2006) (178)
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (2013) (178)
CD169+ MACROPHAGES PRESENT LIPID ANTIGENS TO MEDIATE EARLY ACTIVATION OF INVARIANT NKT CELLS IN LYMPH NODES (2010) (177)
Acyl-CoA Carboxylases (accD2 and accD3), Together with a Unique Polyketide Synthase (Cg-pks), Are Key to Mycolic Acid Biosynthesis in Corynebacterianeae Such as Corynebacterium glutamicum and Mycobacterium tuberculosis* (2004) (176)
MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria (2012) (172)
Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice (2012) (171)
Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria (2011) (168)
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors (2012) (168)
Cd1b-Mediated T Cell Recognition of a Glycolipid Antigen Generated from Mycobacterial Lipid and Host Carbohydrate during Infection (2000) (167)
Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation (2002) (166)
Activated NKT Cells Inhibit Autoimmune Diabetes through Tolerogenic Recruitment of Dendritic Cells to Pancreatic Lymph Nodes1 (2005) (165)
Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation (2009) (164)
Mycobacterium tuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells (2004) (164)
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator (2003) (162)
Biosynthesis of Mycobacterial Lipoarabinomannan* (1997) (162)
Biosynthesis of the Linkage Region of the Mycobacterial Cell Wall (*) (1996) (160)
Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. (2011) (157)
Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b (2011) (153)
Inflammation-induced formation of fat-associated lymphoid clusters (2015) (152)
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis (1996) (149)
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis. (2003) (148)
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB (2012) (147)
Identification of a Novel Arabinofuranosyltransferase (AftA) Involved in Cell Wall Arabinan Biosynthesis in Mycobacterium tuberculosis* (2006) (146)
Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis (2010) (146)
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases (2006) (145)
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. (2010) (141)
Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium tuberculosis* (2003) (140)
EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets (2007) (133)
Deletion of Cg-emb in Corynebacterianeae Leads to a Novel Truncated Cell Wall Arabinogalactan, whereas Inactivation of Cg-ubiA Results in an Arabinan-deficient Mutant with a Cell Wall Galactan Core* (2005) (132)
Functional Role of the PE Domain and Immunogenicity of the Mycobacterium tuberculosis Triacylglycerol Hydrolase LipY (2007) (131)
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity (2009) (129)
Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains. (2002) (129)
Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors (2011) (128)
GATA-3 Regulates the Development and Function of Invariant NKT Cells1 (2006) (128)
Galactan Biosynthesis in Mycobacterium tuberculosis (2001) (124)
Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae. (2004) (123)
Lipids and Carbohydrates of Mycobacterium tuberculosis (1994) (122)
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. (2011) (122)
Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome (2013) (122)
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component (2011) (122)
Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum. (2005) (121)
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds. (2004) (120)
Biochemical Characterization of Acyl Carrier Protein (AcpM) and Malonyl-CoA:AcpM Transacylase (mtFabD), Two Major Components ofMycobacterium tuberculosis Fatty Acid Synthase II* (2001) (118)
Synthesis of the Arabinose Donor .beta.-D-Arabinofuranosyl-1-monophosphoryldecaprenol, Development of a Basic Arabinosyl-Transferase Assay, and Identification of Ethambutol as an Arabinosyl Transferase Inhibitor (1995) (117)
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition (2006) (116)
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis. (2002) (115)
Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance. (2004) (115)
Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3 (2013) (114)
Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria (2007) (114)
3‐Ketosteroid 9α‐hydroxylase is an essential factor in the pathogenesis of Mycobacterium tuberculosis (2010) (113)
Interplay of Cytokines and Microbial Signals in Regulation of CD1d Expression and NKT Cell Activation1 (2005) (113)
The Condensing Activities of the Mycobacterium tuberculosis Type II Fatty Acid Synthase Are Differentially Regulated by Phosphorylation* (2006) (112)
Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules (2007) (112)
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. (2002) (112)
Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi. (2011) (112)
A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection (2008) (111)
Identification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis* (2007) (111)
Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis (1999) (111)
The Two Carboxylases of Corynebacterium glutamicum Essential for Fatty Acid and Mycolic Acid Synthesis (2007) (109)
Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target (2016) (109)
The pimB Gene of Mycobacterium tuberculosis Encodes a Mannosyltransferase Involved in Lipoarabinomannan Biosynthesis* (1999) (108)
Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production (2008) (106)
Conserved and Heterogeneous Lipid Antigen Specificities of CD1d-Restricted NKT Cell Receptors1 (2006) (106)
Biosynthesis of the Galactan Component of the Mycobacterial Cell Wall* (2000) (106)
Truncated Structural Variants of Lipoarabinomannan in Ethambutol Drug-resistant Strains of Mycobacterium smegmatis (1996) (105)
CD1d-restricted T cell activation by nonlipidic small molecules. (2004) (104)
Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs (2013) (104)
Mycobacterium tuberculosis cell envelope. (1996) (103)
A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens (2014) (102)
A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties (2011) (101)
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition. (2004) (101)
Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis (2009) (99)
Metagenomic analysis of tuberculosis in a mummy. (2013) (96)
Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis (2013) (96)
Lysosomal Localization of Murine CD1d Mediated by AP-3 Is Necessary for NK T Cell Development 1 (2003) (95)
A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection. (2011) (94)
Preparation of cell-wall fractions from mycobacteria. (1998) (93)
The crystal structure of human CD1d with and without alpha-galactosylceramide. (2005) (93)
Arylamine N-Acetyltransferase Is Required for Synthesis of Mycolic Acids and Complex Lipids in Mycobacterium bovis BCG and Represents a Novel Drug Target (2004) (92)
Inhibition of UDP-Gal Mutase and Mycobacterial Galactan Biosynthesis by Pyrrolidine Analogues of Galactofuranose (1997) (92)
Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction (2014) (91)
The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid12 (2003) (91)
Essential role for autophagy during invariant NKT cell development (2014) (90)
MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A (2018) (90)
Cutting Edge: Nonglycosidic CD1d Lipid Ligands Activate Human and Murine Invariant NKT Cells1 (2008) (89)
Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity* (2004) (87)
Biosynthesis of mycobacterial arabinogalactan: identification of a novel α(1→3) arabinofuranosyltransferase (2008) (86)
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets. (2007) (85)
Role of Phosphatidylinositol Mannosides in the Interaction between Mycobacteria and DC-SIGN (2009) (85)
Improved Outcomes in NOD Mice Treated with a Novel Th2 Cytokine-Biasing NKT Cell Activator1 (2007) (84)
Structural elucidation of a novel family of acyltrehaloses from Mycobacterium tuberculosis. (1992) (82)
Mannan Chain Length Controls Lipoglycans Signaling via and Binding to TLR21 (2008) (82)
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum (2007) (82)
The Bovine CD1 Family Contains Group 1 CD1 Proteins, but No Functional CD1d1 (2006) (81)
Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages. (2016) (81)
Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum. (2005) (80)
Identification of an α(1→6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis (2007) (80)
The C-Type Lectin Receptor CLECSF8/CLEC4D Is a Key Component of Anti-Mycobacterial Immunity (2015) (79)
Peripheral NK1.1− NKT Cells Are Mature and Functionally Distinct from Their Thymic Counterparts1 (2007) (78)
Regulatory iNKT cells lack PLZF expression and control Treg cell and macrophage homeostasis in adipose tissue (2014) (78)
Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. (2007) (77)
Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. (2007) (77)
Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria* (2003) (77)
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis. (2006) (76)
Serum lipids regulate dendritic cell CD1 expression and function (2008) (76)
Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin1 (2009) (76)
Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice. (2008) (74)
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis. (2002) (73)
Expansion and Hyperactivity of CD1d-Restricted NKT Cells during the Progression of Systemic Lupus Erythematosus in (New Zealand Black × New Zealand White)F1 Mice1 (2005) (73)
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. (2010) (73)
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone (2011) (73)
Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay. (1997) (72)
Inactivation of Corynebacterium glutamicum NCgl0452 and the Role of MgtA in the Biosynthesis of a Novel Mannosylated Glycolipid Involved in Lipomannan Biosynthesis* (2007) (72)
Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells (2017) (71)
Distinct Endosomal Trafficking Requirements for Presentation of Autoantigens and Exogenous Lipids by Human CD1d Molecules1 (2007) (70)
The Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III Activity Is Inhibited by Phosphorylation on a Single Threonine Residue* (2009) (70)
Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses (2018) (70)
NKT cells direct monocytes into a DC differentiation pathway (2007) (69)
Human autoreactive T cells recognize CD1b and phospholipids (2015) (69)
Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. (2007) (68)
Identification of a novel α(1→6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant (2008) (67)
Identification of KasA as the cellular target of an anti-tubercular scaffold (2016) (66)
LosA, a Key Glycosyltransferase Involved in the Biosynthesis of a Novel Family of Glycosylated Acyltrehalose Lipooligosaccharides from Mycobacterium marinum* (2005) (66)
Fine Specificity of TCR Complementarity-Determining Region Residues and Lipid Antigen Hydrophilic Moieties in the Recognition of a CD1-Lipid Complex1 (2002) (65)
Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex. (2007) (65)
Current status and future development of antitubercular chemotherapy (2002) (64)
Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile. (2002) (64)
The mycobacterial cell wall: biosynthesis of arabinogalactan and lipoarabinomannan. (1997) (63)
The role of hydrophobicity in tuberculosis evolution and pathogenicity (2017) (63)
Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d. (2007) (62)
Transposon Mutagenesis of Mb0100 at the ppe1-nrp Locus in Mycobacterium bovis Disrupts Phthiocerol Dimycocerosate (PDIM) and Glycosylphenol-PDIM Biosynthesis, Producing an Avirulent Strain with Vaccine Properties At Least Equal to Those of M. bovis BCG (2005) (62)
Mycobacterium tuberculosis Complex Lipid Virulence Factors Preserved in the 17,000-Year-Old Skeleton of an Extinct Bison, Bison antiquus (2012) (62)
The 5-deoxy-5-methylthio-xylofuranose residue in mycobacterial lipoarabinomannan. absolute stereochemistry, linkage position, conformation, and immunomodulatory activity. (2006) (61)
The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid (2004) (59)
Mycolic acids: deciphering and targeting the Achilles' heel of the tubercle bacillus (2015) (59)
Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity. (2002) (58)
The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module (2011) (58)
Presentation of α‐galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts (2004) (58)
CD1a and CD1c Activate Intrathyroidal T Cells during Graves’ Disease and Hashimoto’s Thyroiditis1 (2005) (57)
THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria (2016) (57)
Identification and structural characterization of an unusual mycobacterial monomeromycolyl‐diacylglycerol (2005) (56)
Role of lipid trimming and CD1 groove size in cellular antigen presentation (2006) (56)
A Simple Mycobacterial Monomycolated Glycerol Lipid Has Potent Immunostimulatory Activity1 (2009) (56)
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. (2005) (56)
A truncated lipoglycan from mycobacteria with altered immunological properties (2010) (55)
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system (2020) (55)
Studies on (β,1→5) and (β,1→6) linked octyl Galf disaccharides as substrates for mycobacterial galactosyltransferase activity (2001) (55)
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis. (2007) (54)
Non-Replicating Mycobacterium tuberculosis Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix (2014) (54)
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol (2020) (53)
Disruption of Cg-Ppm1, a Polyprenyl Monophosphomannose Synthase, and the Generation of Lipoglycan-less Mutants in Corynebacterium glutamicum* (2003) (53)
The Mechanism of Splenic Invariant NKT Cell Activation Dictates Localization In Vivo (2013) (52)
The molecular bases of δ/αβ T cell–mediated antigen recognition (2014) (52)
Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH (2009) (52)
Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. (2008) (50)
Osteological and Biomolecular Evidence of a 7000-Year-Old Case of Hypertrophic Pulmonary Osteopathy Secondary to Tuberculosis from Neolithic Hungary (2013) (50)
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics (2010) (50)
Phosphatidylinositol synthesis in mycobacteria. (1999) (49)
Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases (2009) (49)
Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death. (2009) (49)
Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d (2010) (49)
Human tuberculosis predates domestication in ancient Syria. (2015) (49)
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases. (2004) (48)
Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia (2009) (48)
Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism. (2006) (48)
Arabinogalactan and lipoarabinomannan biosynthesis: structure, biogenesis and their potential as drug targets. (2012) (48)
Natural killer T-cell autoreactivity leads to a specialized activation state. (2008) (47)
Alpha-galactosylceramide as a therapeutic agent for pulmonary Mycobacterium tuberculosis infection. (2010) (47)
Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity. (2011) (47)
Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis. (2007) (47)
Direct Measurement of Antigen Binding Properties of CD1 Proteins Using Fluorescent Lipid Probes* (2004) (47)
NKT Cell Subsets Mediate Differential Proatherogenic Effects in ApoE−/− Mice (2009) (47)
Unexpected Link between Lipooligosaccharide Biosynthesis and Surface Protein Release in Mycobacterium marinum* (2012) (46)
Characterization of the putative operon containing arylamine N‐acetyltransferase (nat) in Mycobacterium bovis BCG (2006) (46)
Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses (2019) (46)
Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase. (2008) (45)
Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis. (2004) (45)
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars (2010) (45)
Maintenance of the marginal zone B cell compartment specifically requires the RNA-binding protein ZFP36L1 (2017) (44)
Stimulation of mycolic acid biosynthesis by incorporation of cis-tetracos-5-enoic acid in a cell-wall preparation from Mycobacterium smegmatis. (1993) (44)
Detection and Strain Typing of Ancient Mycobacterium leprae from a Medieval Leprosy Hospital (2013) (44)
Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall. (2007) (43)
Novel Generation Mycobacterial Adjuvant Based on Liposome-Encapsulated Monomycoloyl Glycerol from Mycobacterium bovis Bacillus Calmette-Guérin1 (2009) (43)
In Vivo Interaction between the Polyprenol Phosphate Mannose Synthase Ppm1 and the Integral Membrane Protein Ppm2 from Mycobacterium smegmatis Revealed by a Bacterial Two-hybrid System* 210 (2003) (43)
Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv (2005) (43)
Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates. (1998) (43)
Ion permeation mechanism of the potassium channel (42)
Synthesis of the naringinase inhibitors l-swainsonine and related 6-C-methyl-l-swainsonine analogues: (6R)-C-methyl-l-swainsonine is a more potent inhibitor of l-rhamnosidase by an order of magnitude than l-swainsonine (2008) (42)
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis. (2002) (42)
Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis (2016) (42)
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening (2017) (42)
Loss of a Mycobacterial Gene Encoding a Reductase Leads to an Altered Cell Wall Containing β-oxo- Mycolic Acid Analogs and Accumulation of Ketones (2008) (42)
Structure, function and biogenesis of the mycobacterial cell wall. (1997) (42)
Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation (2015) (41)
Saposins utilize two strategies for lipid transfer and CD1 antigen presentation (2012) (41)
Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall. (2004) (40)
Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. (2003) (40)
Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells (2015) (40)
Natural killer T‐cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses (2008) (40)
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase (2010) (40)
Expression of CD1d Molecules by Human Schwann Cells and Potential Interactions with Immunoregulatory Invariant NK T Cells1 (2006) (39)
Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface (2017) (39)
Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. (2003) (39)
Ligation of arabinogalactan to peptidoglycan in the cell wall of Mycobacterium smegmatis requires concomitant synthesis of the two wall polymers. (2002) (39)
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis. (2006) (39)
Discrimination between bacterial phenotypes using glyco-nanoparticles and the impact of polymer coating on detection readouts. (2014) (39)
Modular approach to triazole-linked 1,6-α-D-oligomannosides to the discovery of inhibitors of Mycobacterium tuberculosis cell wall synthetase. (2010) (39)
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase. (2015) (39)
Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching (2011) (39)
Polyprenyl Phosphate Biosynthesis inMycobacterium tuberculosis and Mycobacterium smegmatis (2000) (39)
Gal‐3 regulates the capacity of dendritic cells to promote NKT‐cell‐induced liver injury (2015) (39)
Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen (2011) (39)
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma (2019) (38)
IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria (2013) (38)
A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe. (2015) (38)
Galactan Biosynthesis in Mycobacterium tuberculosis IDENTIFICATION OF A BIFUNCTIONAL UDP-GALACTOFURANOSYLTRANSFERASE* (2001) (38)
Studies on n-Octyl-5-(α-d-arabinofuranosyl)-β-d-galactofuranosides for Mycobacterial Glycosyltransferase Activity (2002) (38)
A Chemical Proteomics Approach to Profiling the ATP-binding Proteome of Mycobacterium tuberculosis * (2013) (37)
IL‐2 triggers specific signaling pathways in human NKT cells leading to the production of pro‐ and anti‐inflammatory cytokines (2008) (37)
Sequence and Analysis of a Plasmid-Encoded Mercury Resistance Operon from Mycobacterium marinum Identifies MerH, a New Mercuric Ion Transporter (2008) (37)
Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex* (2012) (37)
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. (2011) (37)
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis. (2008) (37)
Pathophysiological Implications of Cell Envelope Structure in Mycobacterium tuberculosis and Related Taxa (2015) (37)
Glycolipid targets of CD1‐mediated T‐cell responses (2001) (36)
Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity. (2001) (36)
An N-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and β2-Microglobulin* (2006) (36)
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses. (2012) (36)
Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge (2015) (35)
Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface (2017) (35)
Osteological, Biomolecular and Geochemical Examination of an Early Anglo-Saxon Case of Lepromatous Leprosy (2015) (35)
Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation (2013) (35)
Ligand-dependent downregulation of MR1 cell surface expression (2020) (35)
Synthesis of a Versatile Building Block for the Preparation of 6-N-Derivatized α-Galactosyl Ceramides: Rapid Access to Biologically Active Glycolipids (2010) (35)
Modulation of CD1d‐restricted NKT cell responses by CD4 (2007) (34)
Biomolecular archaeology of ancient tuberculosis: response to "Deficiencies and challenges in the study of ancient tuberculosis DNA" by Wilbur et al. (2009) (2009) (34)
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway (2016) (34)
Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors. (1998) (34)
Tuberculosis chemotherapy: recent developments and future perspectives. (2007) (34)
A Rapid Fluorescence-Based Assay for Classification of iNKT Cell Activating Glycolipids (2011) (34)
Ancient mycobacterial lipids: Key reference biomarkers in charting the evolution of tuberculosis. (2015) (34)
Characterization of the Corynebacterium glutamicum ΔpimB′ ΔmgtA Double Deletion Mutant and the Role of Mycobacterium tuberculosis Orthologues Rv2188c and Rv0557 in Glycolipid Biosynthesis (2009) (33)
Structural and functional features of Rhodococcus ruber lipoarabinomannan. (2003) (33)
Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB′ mutant (2008) (33)
Defects in glycopeptidolipid biosynthesis confer phage I3 resistance in Mycobacterium smegmatis. (2009) (33)
Tsukamurella paurometabola Lipoglycan, a New Lipoarabinomannan Variant with Pro-inflammatory Activity* (2004) (33)
A waxy tale, by Mycobacterium tuberculosis (2005) (32)
The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells (2016) (32)
Synthesis of α-Glucan in Mycobacteria Involves a Hetero-octameric Complex of Trehalose Synthase TreS and Maltokinase Pep2 (2013) (32)
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). (2002) (32)
Acceptor Substrate Discrimination in Phosphatidyl-myo-inositol Mannoside Synthesis (2010) (32)
Congenic Analysis of the NKT Cell Control Gene Nkt2 Implicates the Peroxisomal Protein Pxmp41 (2008) (31)
Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens (2016) (31)
Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition (2013) (31)
CD1d‐mediated activation of group 3 innate lymphoid cells drives IL‐22 production (2016) (31)
7000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence. (2015) (30)
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. (2008) (30)
Re-emergence of tuberculosis: strategies and treatment (2002) (30)
Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis. (2015) (30)
Benzothiazinones Mediate Killing of Corynebacterineae by Blocking Decaprenyl Phosphate Recycling Involved in Cell Wall Biosynthesis* (2014) (30)
Characterization of the in vitro synthesized arabinan of mycobacterial cell walls. (1997) (30)
Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity (2015) (29)
Characterization and regulation of inositol monophosphatase activity in Mycobacterium smegmatis. (2002) (29)
Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1 (2018) (29)
Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide (2009) (29)
Modified mannose disaccharides as substrates and inhibitors of a polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis. (2005) (29)
Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target (2014) (29)
Improving Mycobacterium bovis Bacillus Calmette-Guèrin as a Vaccine Delivery Vector for Viral Antigens by Incorporation of Glycolipid Activators of NKT Cells (2014) (29)
An integrated procedure for the direct detection of characteristic lipids in tuberculosis patients. (1993) (29)
Cognate interaction with iNKT cells expands IL-10–producing B regulatory cells (2015) (29)
Trehalose-containing lipooligosaccharides of Mycobacterium gordonae: presence of a mono-O-methyltetra-O-acyltrehalose "core" and branching in the oligosaccharide backbone. (1993) (29)
Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity (2013) (29)
Cytotoxic Mediators in Paradoxical HIV–Tuberculosis Immune Reconstitution Inflammatory Syndrome (2015) (29)
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis (2013) (28)
Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration. (2009) (28)
α-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents (2010) (28)
Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase. (2001) (27)
Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2 (2018) (27)
Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes (2017) (27)
New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides (2012) (27)
BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments. (2005) (27)
Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphurea. (2003) (27)
Chemoenzymatic synthesis of feruloyl d-arabinose as a potential anti-mycobacterial agent (2007) (27)
Inhibition of naringinase (L-rhamnosidase) by piperidine analogues of L-rhamnose: Scaffolds for libraries incorporating trihydroxypipecolic acids (1996) (27)
Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria (2012) (27)
CD38 Is Required for the Peripheral Survival of Immunotolerogenic CD4+ Invariant NK T Cells in Nonobese Diabetic Mice1 (2006) (27)
Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity (2020) (26)
Studies on β-d-Galf -(1→4)-α-l-Rhap octyl analogues as substrates for mycobacterial galactosyl transferase activity (1999) (26)
Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole. (2005) (26)
Characterisation of phenolic glycolipids from Mycobacterium marinum. (1990) (26)
Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. (2009) (26)
Amide Analogues of CD1d Agonists Modulate iNKT-Cell-Mediated Cytokine Production (2012) (25)
Mimics of l-rhamnose: Anomeric spirohydantoins and diketopiperazines-approaches to novel N-linked glycopeptides of rhamnofuranose (1996) (25)
Structural elucidation and antigenicity of a novel phenolic glycolipid antigen from Mycobacterium haemophilum. (1991) (25)
Synthetic disaccharide analogs as potential substrates and inhibitors of a mycobacterial polyprenol monophosphomannose-dependent α-(1→6)-mannosyltransferase (2005) (25)
Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones. (2018) (25)
Synthesis of methyl (Z)-tetracos-5-enoate and both enantiomers of ethyl (E)-6-methyltetracos-4-enoate: possible intermediates in the biosynthesis of mycolic acids in mycobacteria. (1993) (25)
A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production (2015) (25)
Ancient DNA analysis - An established technique in charting the evolution of tuberculosis and leprosy. (2015) (25)
Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant (2007) (25)
Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function (2018) (24)
Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues (2012) (24)
Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi. (1993) (24)
Mimics of l-rhamnose: Analogues of rhamnopyranose containing a constituent α-amino acid at the anomeric position. A rhamnopyranose analogue of hydantocidin (1996) (24)
The Mycobacterial Cell Envelope (1997) (24)
The ppm Operon Is Essential for Acylation and Glycosylation of Lipoproteins in Corynebacterium glutamicum (2012) (24)
A Lipomannan Variant with Strong TLR-2-dependent Pro-inflammatory Activity in Saccharothrix aerocolonigenes* (2005) (24)
Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets (2018) (23)
New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria. (1994) (23)
Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes. (2012) (23)
Selectfluor and NFSI exo-glycal fluorination strategies applied to the enhancement of the binding affinity of galactofuranosyltransferase GlfT2 inhibitors. (2014) (23)
Differential effects of Mycobacterium bovis - derived polar and apolar lipid fractions on bovine innate immune cells (2012) (23)
Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step. (1997) (23)
The molecular bases of delta/alpha beta T cell-mediated antigen recognition (2014) (23)
Mycobacterium tuberculosis pks 12 Produces a Novel Polyketide Presented by CD 1 c to T Cells (2004) (23)
Synthesis and biological activity of α-glucosyl C24:0 and C20:2 ceramides (2010) (23)
Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis (2012) (23)
Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis. (2004) (22)
Characterization of the specific antigenicity of Mycobacterium fortuitum. (1992) (22)
Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis (2016) (22)
Cytidine diphosphate-diacylglycerol synthesis in Mycobacterium smegmatis. (2002) (22)
The Interplay of DNA and Lipid Biomarkers in the Detection of Tuberculosis and Leprosy in Mummies and other Skeletal Remains (2011) (22)
Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis (2003) (22)
Identification of a Glycosyltransferase from Mycobacterium marinum Involved in Addition of a Caryophyllose Moiety in Lipooligosaccharides (2011) (22)
Gold nanoparticle-linked analysis of carbohydrate-protein interactions, and polymeric inhibitors, using unlabelled proteins; easy measurements using a 'simple' digital camera. (2013) (21)
Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 (2008) (21)
Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis. (2010) (21)
Antimycobacterial Activity and Mechanism of Action of NAS-91 (2007) (21)
Regulation of CD1 Antigen-presenting Complex Stability* (2010) (21)
Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties (2019) (21)
Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis. (2009) (21)
Human CD4+ invariant NKT cells are involved in antibacterial immunity against Brucella suis through CD1d‐dependent but CD4‐independent mechanisms (2009) (21)
Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen. (2008) (20)
Genetics of Mycobacterial Arabinogalactan and Lipoarabinomannan Assembly. (2014) (20)
Identification of distinct human invariant natural killer T-cell response phenotypes to alpha-galactosylceramide (2008) (20)
Ionic contrast terahertz near-field imaging of axonal water fluxes (2007) (20)
Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen (2016) (20)
Phage display‐derived recombinant antibodies with TCR‐like specificity against α‐galactosylceramide and its analogues in complex with human CD1d molecules (2008) (20)
The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues. (1999) (20)
Glycomimetic Inhibitors of Mycobacterial Glycosyltransferases: Targeting the TB Cell Wall (2008) (20)
Molecular Biomarkers for Ancient Tuberculosis (2012) (19)
Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars (2016) (19)
Crystal Structure of Bovine CD1b3 with Endogenously Bound Ligands (2010) (18)
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+ (2007) (18)
Differential Arabinan Capping of Lipoarabinomannan Modulates Innate Immune Responses and Impacts T Helper Cell Differentiation (2012) (18)
Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases. (2004) (18)
Synthesis and recycling of the mycobacterial cell envelope (2021) (18)
Gram-Positive Bacterial Lipoglycans Based on a Glycosylated Diacylglycerol Lipid Anchor Are Microbe-Associated Molecular Patterns Recognized by TLR2 (2013) (18)
Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis. (2009) (18)
Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH. (2009) (18)
Chemistry of the Lyxose-Containing Mycobacteriophage Receptors of Mycobacterium phlei/Mycobacterium smegmatis† (1996) (18)
Positive Diagnosis of Ancient Leprosy and Tuberculosis Using Ancient DNA and Lipid Biomarkers (2017) (17)
Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan (2016) (17)
Regulation of cell wall synthesis and growth. (2007) (17)
Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity (2017) (17)
Tuberculosis: a balanced diet of lipids and carbohydrates. (2008) (17)
Essentials in the use of mycolic acid biomarkers for tuberculosis detection: response to “High-throughput mass spectrometric analysis of 1400-year-old mycolic acids as biomarkers for ancient tuberculosis infection” by Mark et al., 2010 (2010) (17)
Mimics ofl-rhamnose: Synthesis of C-glycosides of L-rhamnofuranose and an α-azidoester as divergent intermediates for combinatorial generation of rhamnofuranose libraries (1996) (17)
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann‐Pick disease type C (2012) (17)
Integrated Strategies for the use of Lipid Biomarkers in the Diagnosis of Ancient Mycobacterial Disease (2012) (17)
Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization. (2008) (16)
Exploring the Substrate Specificity of a Mycobacterial Polyprenol Monophosphomannose‐Dependent α‐(1→6)‐Mannosyltransferase (2008) (16)
Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach (2018) (16)
The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid. (2013) (16)
Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells. (2011) (16)
Non‐glycosidic compounds can stimulate both human and mouse iNKT cells (2016) (16)
Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations. (2011) (16)
New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: Inhibition of antigen 85C mycolyltransferase activity and cytotoxicity (2006) (15)
Identification of a Terminal Rhamnopyranosyltransferase (RptA) Involved in Corynebacterium glutamicum Cell Wall Biosynthesis (2009) (15)
Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis. (1996) (15)
CD1a selectively captures endogenous cellular lipids that broadly block T cell response (2021) (15)
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT). (2007) (15)
Oligosaccharides as inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues. (2005) (15)
Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan (2010) (15)
Synthesis and Biological Evaluation of Imino Sugar−Oligoarabinofuranoside Hybrids, a New Class of Mycobacterial Arabinofuranosyltransferase Inhibitors (2003) (15)
Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library. (2007) (15)
New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections (2008) (15)
Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes (2017) (14)
Morphological and biomolecular evidence for tuberculosis in 8th century AD skeletons from Bélmegyer-Csömöki domb, Hungary. (2015) (14)
Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries. (2007) (14)
Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease (2020) (14)
β-Mannosylceramide Activates Type I Natural Killer T Cells to Induce Tumor Immunity without Inducing Long-Term Functional Anergy (2013) (14)
Elucidation of a protein-protein interaction network involved in Corynebacterium glutamicum cell wall biosynthesis as determined by bacterial two-hybrid analysis (2014) (14)
Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells (2019) (14)
Characteristic new members of the phthiocerol and phenolphthiocerol families from Mycobacterium ulcerans. (1990) (14)
Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities (2021) (13)
Deletion of manC in Corynebacterium glutamicum results in a phospho-myo-inositol mannoside- and lipoglycan-deficient mutant. (2012) (13)
The hydrolase LpqI primes mycobacterial peptidoglycan recycling (2018) (13)
Synthesis and biological activity of α-l-fucosyl ceramides, analogues of the potent agonist, α-d-galactosyl ceramide KRN7000 (2010) (13)
Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis. (2007) (13)
Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria. (1994) (13)
Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay. (2002) (13)
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α -glucan pathway (2012) (13)
Structural Study of Lipomannan and Lipoarabinomannan fromMycobacterium chelonae (2002) (12)
Synthesis of threitol ceramide and [14C]threitol ceramide, non-glycosidic analogues of the potent CD1d antigen α-galactosyl ceramide (2009) (12)
Distinct Requirements for CD1d Intracellular Transport for Development of Vα14 iNKT Cells1 (2009) (12)
Expression of CD1c enhances human invariant NKT cell activation by α-GalCer. (2013) (12)
Utilisation of the Prestwick Chemical Library to identify drugs that inhibit the growth of mycobacteria (2018) (12)
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis. (2007) (12)
Identification of the leprosy bacillus and related mycobacteria by analysis of mycocerosate profiles. (1993) (12)
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis. (2002) (12)
Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids. (2004) (12)
Requirement for Invariant Chain in Macrophages for Mycobacterium tuberculosis Replication and CD1d Antigen Presentation (2011) (12)
Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells. (2011) (11)
Design, Synthesis, and Functional Activity of Labeled CD1d Glycolipid Agonists (2013) (11)
Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall (2020) (11)
MKAN27435 Is Required for the Biosynthesis of Higher Subclasses of Lipooligosaccharides in Mycobacterium kansasii (2015) (11)
University of Birmingham Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones. (2008) (11)
Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation. (2018) (11)
Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies. (2010) (11)
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells (2019) (10)
On the Way to Glycoprocessing Inhibitors − Synthesis of an Imidazolo-Nectrisine-Phosphono Acid Derivative: A Potential Glycosyltranferase Inhibitor (2003) (10)
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae (2018) (10)
Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase (2016) (10)
Mycobacterial drug discovery (2020) (10)
AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core (2017) (10)
Calreticulin Controls the Rate of Assembly of CD1d Molecules in the Endoplasmic Reticulum* (2010) (10)
Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase. (2006) (9)
A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model (2015) (9)
Structural definition of the glycopeptidolipids and the pyruvylated, glycosylated acyltrehalose from Mycobacterium butyricum. (1995) (9)
Endoplasmic Reticulum Glycoprotein Quality Control Regulates CD1d Assembly and CD1d-mediated Antigen Presentation* (2013) (9)
Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation (2011) (9)
Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis (2020) (9)
Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51. (2007) (9)
A multi-targeting pre-clinical candidate against drug-resistant tuberculosis. (2021) (9)
The synthesis of methyl 4-(2-octadecylcyclopropen-l-yl)butanoate: a possible inhibitor in mycolic acid biosynthesis (1993) (8)
Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2 (2020) (8)
New members of the phthiocerol and phenolphthiocerol families from Mycobacterium marinum (1989) (8)
Lipoarabinomannanand relatedglycoconjugates : structure , biogenesis and role inMycobacteriumtuberculosis physiologyand host ^ pathogen interaction (2011) (8)
Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy (2019) (8)
Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. (2015) (8)
Comparative studies of antigenic glycolipids of mycobacteria related to the leprosy bacillus. (1989) (7)
Tuberculosis diagnostics: overcoming ancient challenges with modern solutions (2020) (7)
Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c). (2003) (7)
7 Antibiotics and New Inhibitors of the Cell Wall (2008) (6)
Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis (2019) (6)
The Glycolipids of Mycobacteria (1993) (6)
A hybrid of the transhydrogenases from Rhodospirillum rubrum and Mycobacterium tuberculosis catalyses rapid hydride transfer but not the complete, proton-translocating reaction. (2006) (6)
"Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes". (2016) (6)
Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation (2019) (5)
Molecular action of antimycobacterial agents and mechanisms of drug resistance in Mycobacterium tuberculosis (1999) (5)
Sugar mimics from sugar lactones (1998) (5)
Crystal structure of the TreS:Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria (2019) (5)
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment (2022) (5)
A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains (2018) (5)
The P5-type ATPase ATP13A1 modulates major histocompatibility complex I-related protein 1 (MR1)-mediated antigen presentation (2021) (5)
PPAR γ controls CD 1 d expression by turning on retinoic acid synthesis in developing human dendritic cells (2006) (5)
Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy (2021) (4)
The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis (2018) (4)
Inflammasome-dependent IL-1 beta production is critical for complete Freund's adjuvant-induced helper T cell polarization (2010) (4)
Colworth prize lecture 2016: exploiting new biological targets from a whole-cell phenotypic screening campaign for TB drug discovery. (2017) (4)
Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes. (2015) (4)
Oldest evidence of tuberculosis in Argentina: A multidisciplinary investigation in an adult male skeleton from Saujil, Tinogasta, Catamarca (905-1030 CE). (2020) (4)
Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis. (2022) (4)
Studies on (beta,1-->5) and (beta,1-->6) linked octyl Gal(f) disaccharides as substrates for mycobacterial galactosyltransferase activity. (2001) (3)
The Cell‐Wall Core of Mycobacterium: Structure, Biogenesis and Genetics (2009) (3)
Mimics of L-Rhamnose: Synthesis of C-Glycosides of L-Rhamnofuranose and an α-Azidoester as Divergent Intermediates for Combinatorial Generation of Rhamnofuranose Libraries. (1996) (3)
A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains (2019) (3)
Osteoarchaeological and paleomicrobiological evidence of leprosy in Hungary (2014) (3)
Determinants of the Inhibition of DprE 1 and CYP 2 C 9 by Antitubercular Thiophenes (2017) (3)
In contrast to other species, α-Galactosylceramide (α-GalCer) is not an immunostimulatory NKT cell agonist in horses. (2015) (3)
Biochemical characterisation of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase (Mt-PrsA) (2010) (3)
Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline (2020) (3)
Deletion of a mycobacterial gene encoding a reductase leads to an altered cell wall containing β-oxo-mycolic acid analogues, and the accumulation of longchain ketones related to mycolic acids. (2008) (3)
Human and mouse Type I Natural Killer T-cell antigen receptors exhibit different fine specificities for CD1d-antigen (2012) (3)
Generation of Liposomes to Study the Effect of Mycobacterium Tuberculosis Lipids on HIV-1 cis- and trans-Infections (2021) (3)
Probing the Mechanism of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH (2005) (2)
The bovine CD 1 D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C 26 fatty acid (2013) (2)
The Distribution and Origins of Ancient Leprosy (2018) (2)
Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2 (2018) (2)
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1D-mediated antigen recognition (2005) (2)
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening (2018) (2)
Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183 (2020) (2)
The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation (2021) (2)
Antibiotics and new inhibitors of the cell envelope (2008) (2)
IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria (2013) (2)
Human Mucosal Associated Invariant T cell proliferation is dependent on a MYC-SLC7A5-Glycolysis metabolic axis (2022) (2)
Recent advances in mycobacterial arabinogalactan biosynthesis in post-genomics era (2002) (2)
Inhibition of Naringinase (L‐Rhamnosidase) by Piperidine Analogues of L‐Rhamnose: Scaffolds for Libraries Incorporating Trihydroxypipecolic Acids. (1997) (2)
Erratum: Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (Proceedings of the National Academy of Sciences of the United States of America (2013) 27:110 (E2510-E2517)) (2013) (2)
Inflammasome-dependent IL-1β production is critical for complete Freund’s adjuvant-induced helper T cell polarization (136.44) (2010) (1)
Bacillus Calmette-Guérin bovis Mycobacterium Monomycoloyl Glycerol from Based on Liposome-Encapsulated Novel Generation Mycobacterial Adjuvant (2009) (1)
A humanized mouse model for in vivo evaluation of invariant Natural Killer T cell responses (2022) (1)
Lipoarabinomannan branching and Th cell differentiation (2012) (1)
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (vol 110, pg E2510, 2013) (2013) (1)
Correction for Lin et al., PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating (2007) (1)
Repurposing Vanoxerine as a new antimycobacterial drug and its impact on the mycobacterial membrane (2022) (1)
Chemical insights into the search for MAIT cells activators. (2020) (1)
Stereochemistry of 2,4-dimethyleicos-2-enoate from the pyruvylated glycolipid of Mycobacterium smegmatis. (1994) (1)
Correction for Muindi et al., Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphinogolipids presented by CD1d (2010) (1)
Mycobacterium tuberculosis EmbR (2006) (1)
Combined functional and kinetic measurements to address the role of saposins in loading CD1d molecules with iNKT cell agonists (2012) (1)
The C-Type Lectin Receptor CLECSF 8 / CLEC 4 D Is a Key Component of Anti-Mycobacterial Immunity Graphical (2015) (1)
Identification of 2-Aminothiazole-4-Carboxylate derivatives active against mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP (2019) (1)
Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity. (2002) (1)
Molecular biomarker studies on the interrelation of ancient leprosy and tuberculosis (2014) (1)
Metabolic syndrome and obesity in an insect (2007) (1)
Proceedings of the Twelfth Annual Conference of the British Association for Biological Anthropology and Osteoarchaeology (2012) (1)
Human and mouse Type I Natural Killer T-cell antigen receptors exhibit different fine specificities for CD 1 d-antigen (2012) (1)
Studies on beta-D-Gal(f)-(1-->4)-alpha-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activity. (1999) (1)
Chapter 2 The Distribution and Origins of Ancient Leprosy (2019) (1)
NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs In Vitro and In Vivo (2022) (1)
Synthesis and Biological Evaluation of a C5‐Biphenyl Thiolactomycin Library. (2008) (0)
IpsA, a novel Lacl-type regulator required for cell wall biosynthesis in Corynebacteria and Mycobacteria (2015) (0)
CD1d/NKT cells (PP-006) (2010) (0)
MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A (2018) (0)
Defining the origins and spread of leprosy using molecular biomarkers (2014) (0)
Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach (2018) (0)
1 Molecular Biomarkers for Ancient Tuberculosis (2012) (0)
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol (2020) (0)
Crystal structure of M. tuberculosis EchA6 bound to ligand GSK729A (2016) (0)
Crystal structure of human TCR Alpha Chain-TRAV12-3, Beta Chain-TRBV6-5, Antigen-presenting molecule CD1d, and Beta-2-microglobulin (2016) (0)
The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis (2022) (0)
Design , synthesis , and functional activity of labeled CD 1 d glycolipid agonists (2013) (0)
Crystal structure of M. tuberculosis EchA6 bound to ligand GSK366A (2016) (0)
New CD1d Agonists: Synthesis and Biological Activity of 6′′-Triazole-Substituted α-Galactosyl Ceramides. (2012) (0)
Tuberculosis Immune Reconstitution - Cytotoxic Mediators in Paradoxical HIV (2015) (0)
Mimics of L-Rhamnose: Anomeric Spirohydantoins and Diketopiperazines - Approaches to Novel N-Linked Glycopeptides Rhamnofuranose. (1996) (0)
Beta-mannosylceramide represents a new class of NKT agonists that induces tumor immunity by a novel IFN-{gamma}-independent mechanism. (2010) (0)
Whole Genome Analysis of Mycobacterium tuberculosis in 18th-Century Natural Mummies from Vác, Hungary (2017) (0)
University of Birmingham Benzothiazinones mediate killing of Corynebacterianeae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis (2014) (0)
Inhibition of UDP‐Gal Mutase and Mycobacterial Galactan Biosynthesis by Pyrrolidine Analogues of Galactofuranose. (1997) (0)
Document S1. Six Figures, Three Tables, and Supplemental Experimental Procedures (2011) (0)
tuberculosis Confers Tolerance to Drug-Sensitive Mycobacterium Keto-Mycolic Acid-Dependent Pellicle Formation 2013 (2013) (0)
Crystal Structure of the Mycobacterium tuberculosis Antigen 85A Protein (2004) (0)
M tuberculosis DprE1 in complex with a covalently bound nitrobenzothiazinone (2018) (0)
Crystal structure of Corynebacterium glutamicum PimB' bound to GDP-Man (orthorhombic crystal form) (2010) (0)
Molnár et al Szeged 2015 SI (2015) (0)
Crystal structure of diaminopimelate epimerase Mycobacterium tuberculosis DapF (2009) (0)
M. tuberculosis DprE1 covalently bound to a nitrobenzoxacinone. (2018) (0)
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis (2023) (0)
Erratum to "The cell surface - A new journal for transkingdom cell wall research" [Cell Surface 1 (2018) 1]. (2020) (0)
Ancient DNA analysis – an established technique in charting the evolution of tuberculosis and 1 leprosy 2 3 4 (2015) (0)
M tuberculosis DprE1 in complex with BTZ043 (2018) (0)
Development of CD8αβ+ iNKT cells in a humanized mouse model (APP3P.112) (2015) (0)
Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222 (2017) (0)
Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8, Antigen-presenting glycoprotein CD1d, and Beta-2-microglobulin (2016) (0)
Novel detection of leprosy in archaeological populations by analysis of mycolic acid lipid biomarkers (2008) (0)
Mycobacterium tuberculosis SuhB (2007) (0)
Abstract 4746: Type I NKT cells mediate anti-tumor immunity through a TNF-α- and NOS-dependent pathway when stimulated with β-ManCer (2011) (0)
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol (2020) (0)
Platensimycin Activity against Mycobacterial b -Ketoacyl-ACP Synthases against M. tuberculosis and the development of new synthetic analogues. (2017) (0)
AcceptorSubstrateDiscriminationinPhosphatidyl-myo-inositol MannosideSynthesis STRUCTURALANDMUTATIONALANALYSISOFMANNOSYLTRANSFERASE CORYNEBACTERIUMGLUTAMICUMPimB (2010) (0)
Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids (2022) (0)
Invariant natural killer T cell–natural killer cell interactions dictate transplantation outcome after (cid:1) -galactosylceramide administration (2009) (0)
Phasing glycosyltransferase PimB′ - P1 symmetry and radiation damage (2010) (0)
Signaling and the Inflammasome Mycobacteria through Mincle/CARD9 the Th17-Promoting Adjuvant Activity of Cord Factor and Peptidoglycan Recapitulate (2013) (0)
Visualization of the splenic iNKT cell effector program reveals cross-talk with dendritic cells at the marginal zone (45.13) (2012) (0)
Immunoregulatory Invariant NK T Cells Schwann Cells and Potential Interactions Expression of CD 1 d Molecules by Human (2006) (0)
Crystal structure of M. tuberculosis EchA6 bound to GSK572A (2016) (0)
Crystal structure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose (2020) (0)
Potential role for CD1d restricted T-cells in the immunopathology of sarcoidosis (2003) (0)
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae (2018) (0)
Crystal structure of M. tuberculosis UspC (tetragonal crystal form) (2016) (0)
Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA-mutant (2007) (0)
The Synthesis of Both Enantiomers of Lactobacillic Acid (I) and Mycolic Acid Analogues (II). (1999) (0)
The crystal structure of Mycobacterium tuberculosis MPT51 (FbpC1) (2003) (0)
Identification and validation of the mode of action of the chalcone anti-myco‐ bacterial compounds (2020) (0)
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose. (2020) (0)
Correction: Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells (2020) (0)
Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA020 (2018) (0)
M. tuberculosis DprE1 in complex with inhibitor TCA1 (2013) (0)
Crystal structure of M. tuberculosis FadB2 (Rv0468) (2019) (0)
Self antigens are partial agonists for NKT cells (B221) (2007) (0)
Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis (2023) (0)
This information is current as-Chain Diversity β Governed by TCR Antigen Specificity of Type I NKT Cells Is (2015) (0)
Crystal structure of M. tuberculosis TreS (2013) (0)
Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA481 (2018) (0)
CD1 Proteins, but No Functional CD1d The Bovine CD1 Family Contains Group 1 (2006) (0)
Enhanced immunogenicity of Mycobacterium bovis BCG through CRISPRi mediated depletion of AftC (2022) (0)
The role of hydrophobicity in tuberculosis evolution and pathogenicity (2017) (0)
Cover Picture: Synthesis and Biological Evaluation of Imino Sugar−Oligoarabinofuranoside Hybrids, a New Class of Mycobacterial Arabinofuranosyltransferase Inhibitors (Eur. J. Org. Chem. 14/2003) (2003) (0)
Mycolic acid-specific T-cells in human tuberculosis are dynamically related to antigen load and exhibit memory expansion after cure (2010) (0)
Bound Bacterial Glycolipid The Crystal Structure of Human CD 1 b with a (2004) (0)
ILCs contribute to CD 1 d-mediated immunity (2016) (0)
Complex Moieties in the Recognition of a CD 1-Lipid Residues and Lipid Antigen Hydrophilic Complementarity-Determining Region Fine Specificity of TCR (2002) (0)
The cell surface – A new journal for transkingdom cell wall research (2017) (0)
Mycobacterium tuberculosis DprE1 in complex with CT325 - monoclinic crystal form (2012) (0)
Biochemical and phenotypic characterisation of the Mycobacterium smegmatis transporter UspABC (2021) (0)
Identifi ' cation of the apparent carrier in mycolic acid synthesis ( mycobacteria / 6-0-mycolyl-mannosyl-1-phosphopolyprenol / antituberculosis drugs ) (2005) (0)
Beta-mannosylceramide represents a new class of NKT agonists that induces tumor immunity by a novel IFN-γ-independent mechanism. (89.7) (2010) (0)
University of Birmingham CD1dmediated activation of group 3 innate lymphoid cells drives IL22 production (2016) (0)
α-Galactosylceramide analogues in cancer immunotherapeutics (P2102) (2013) (0)
Abstract 1556: α-mannosylceramide, a new NKT cell agonist, induces tumor immunity without anergy induction in NKT cells (2012) (0)
Mycobacterium tuberculosis FabD (2007) (0)
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T-cells. (2023) (0)
Cells in Nonobese Diabetic Mice Invariant NK T + of Immunotolerogenic CD4 CD38 Is Required for the Peripheral Survival (2006) (0)
Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity (2020) (0)
Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties (2019) (0)
Mycobacterium tuberculosis DprE1 in complex with CT319 (2012) (0)
Crystal structure of the C-terminal extracellular domain of Mycobacterium tuberculosis EmbC (2010) (0)
Complex of Mycobacterium smegmatis trehalose synthase with maltokinase (2017) (0)
The hydrolase LpqI primes mycobacterial peptidoglycan recycling (2019) (0)
Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1 (2018) (0)
Crystal structure of M. tuberculosis EchA6 bound to C20-CoA (2016) (0)
Crystal structure of Corynebacterium glutamicum PimB' in complex with GDP-Man (triclinic crystal form) (2010) (0)
Mycobacterium tuberculosis DprE1 - monoclinic crystal form (2012) (0)
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB) and is responsible for about 1.6 million deaths annually (WHO: (2011) (0)
Schwann Cells and Potential Interactions Expression of CD1d Molecules by Human (2006) (0)
Mimics of L‐Rhamnose: Analogues of Rhamnopyranose Containing a Constituent α‐Amino Acid at the Anomeric Position. A Rhamnopyranose Analogue of Hydantocidin. (1996) (0)
Direct activation of iNKT cells by CD1d bound glycolipid antigens leads to a different kinetics of iNKT activation and expansion (2016) (0)
Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on ‘Infectious diseases and Neolithic transformations’ (Fuchs et al. 2019 The Holocene 29: 1545–1557) (2020) (0)
Mycobacterium tuberculosis DprE1 - hexagonal crystal form (2012) (0)
Antigen for Diverse NKT Cells Identification of a Potent Microbial Lipid (2015) (0)
University of Birmingham AftD functions as an 15 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core (2018) (0)
Identiﬁcation of a Glycosyltransferase from Mycobacterium marinum Involved in Addition of a Caryophyllose Moiety in Lipooligosaccharides (cid:1) † (2011) (0)
Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface (2017) (0)
Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets (2018) (0)
Title : Human tuberculosis predates domestication in ancient Syria Author names and affiliations : (2015) (0)
Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8 and Beta Chain-TRBV7-8 (2016) (0)
Crystal structure of M. tuberculosis EchA6 bound to ligand GSK951A (2016) (0)
Corrections (2008) (0)
Antigen 85C with octylthioglucoside in active site (2004) (0)
ActivationRegulation of CD1d Expression and NKT Cell Interplay of Cytokines and Microbial Signals in (2005) (0)
University of Birmingham The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells (2016) (0)
X-ray crystal structure of R46A,R161A mutant of Mycobacterium tuberculosis FabH (2005) (0)
Cryo-EM structure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol (2020) (0)
Crystal structure of TetR family repressor M. tuberculosis EthR (2004) (0)
Mycobacterium tuberculosis DprE1 mutant Y314C in complex with TCA1 (2018) (0)
Mycobacterium tuberculosis DprE1 in complex with CT325 - hexagonal crystal form (2012) (0)
Primary Dendritic Cells Maturation of Monocyte-Derived and Invariant T Cells Induces CD40L-Dependent Activation of Human Mucosal-Associated (2017) (0)
THE MYCOBACTERIAL CELL WALL: ARABINOGALACTAN AND LIPOARABINOMANNAN BIOSYNTHESIS (1997) (0)
Vanoxerine kills mycobacteria through membrane depolarization and efflux inhibition (2023) (0)
Calmette-Guérin 1 (2009) (0)
X-ray crystal structure of W42A,R161A double mutant of Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III (2005) (0)
Human CD1d Molecules Autoantigens and Exogenous Lipids by Requirements for Presentation of Distinct Endosomal Trafficking (2007) (0)
CD1d-restricted NKT cell function prevents insulin resistance in lean mice, and is regulated by adipocytes and is regulated by adipocytes (2012) (0)
Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant (2007) (0)
Abstract 5613: Beta-mannosylceramide: a novel NKT cell agonist which synergizes with alpha-galactocylceramide to induce protection against tumors (2010) (0)
Arabinofuranose Disaccharide Analogues as Inhibitors of Mycobacterium tuberculosis. (2004) (0)
Mycobacteria recycle their peptidoglycan via a novel pathway which influences antimicrobial resistance and limits proliferation in macrophages. (2018) (0)
Elucidation of a protein-protein interaction network involved in Corynebacterium glutamicum cell wall biosynthesis as determined by bacterial two-hybrid analysis (2014) (0)
g That Preferentially Induces IFN-A Novel Glycolipid Antigen for NKT Cells (2015) (0)
Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1 (2022) (0)
Activation of V alpha 14i NKT cells requires a unique kinetics for the TCR interaction (2003) (0)
Crystal structure of M. tuberculosis EchA6 (apo, trigonal crystal form) (2016) (0)
Two‐way regulation of protein expression for identification and validation of on‐target inhibitors of Mycobacterium tuberculosis (2022) (0)
Crystal structure of M. tuberculosis EchA6 bound to ligand GSK059A. (2016) (0)
The P5-ATPase ATP13A1 modulates MR1-mediated antigen presentation (2021) (0)
Ligand-dependent modulation of MR1-restricted antigen presentation (2022) (0)
University of Birmingham Regulation of CD1 Antigen-presenting Complex Stability (2010) (0)
Dominant iNKT cells subsets differentially control immunity to allografts according to the site of T cell priming (2016) (0)
Defining aspects of noncognate splenic iNKT cell help which contribute to humoral memory (INC6P.403) (2014) (0)
Cell Activation Dictates Localization In Vivo The Mechanism of Splenic Invariant NKT (2013) (0)
Detection of mycobacteria in infected tissue. (1989) (0)
Immunostimulatory Activity Glycerol Lipid Has Potent A Simple Mycobacterial Monomycolated (2008) (0)
Atypical T cell receptor usage defines a population of Natural Killer T cells with distinct glycolipid antigen recognition properties (160.13) (2011) (0)
Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide (2006) (0)
Crystal structure of M. tuberculosis UspC (monoclinic crystal form) (2016) (0)
African Salmonella Typhimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB (2019) (0)
University of Birmingham Modular Synthesis of Diverse Natural Product-like Macrocycles (2017) (0)
Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei. Commentary (2003) (0)
PS15 - 74. CD1d-restricted NKT cell function prevents insulin resistance in lean mice, and is regulated by adipocytes (2012) (0)

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