Gustavo Barja
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Computer Science
Gustavo Barja's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Gustavo Barja's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals (2000) (529)
- Mitochondrial Oxygen Radical Generation and Leak: Sites of Production in States 4 and 3, Organ Specificity, and Relation to Aging and Longevity (1999) (513)
- Free radicals and aging (2004) (415)
- Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart (2001) (368)
- The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach (1998) (364)
- International conference on the healthy effect of virgin olive oil (2005) (299)
- Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. (2002) (283)
- Minireview: the role of oxidative stress in relation to caloric restriction and longevity. (2005) (279)
- Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. (2003) (274)
- Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds. (1994) (271)
- Membrane Fatty Acid Unsaturation, Protection against Oxidative Stress, and Maximum Life Span (2002) (264)
- Is the mitochondrial free radical theory of aging intact? (2006) (248)
- Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. (2013) (245)
- Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. (2006) (237)
- Mitochondrial Free Radical Production and Aging in Mammals and Birds a (1998) (237)
- Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism? (2004) (224)
- Rate of generation of oxidative stress-related damage and animal longevity. (2002) (221)
- Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon (1997) (216)
- Endogenous oxidative stress: relationship to aging, longevity and caloric restriction (2002) (212)
- Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies. (2007) (212)
- Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. (1998) (210)
- Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins (2006) (208)
- Localization at Complex I and Mechanism of the Higher Free Radical Production of Brain Nonsynaptic Mitochondria in the Short-Lived Rat Than in the Longevous Pigeon (1998) (207)
- H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved (1998) (170)
- The mitochondrial free radical theory of aging. (2014) (160)
- Minireview: The Quantitative Measurement of H2O2 Generation in Isolated Mitochondria (2002) (157)
- Localization of the Site of Oxygen Radical Generation inside the Complex I of Heart and Nonsynaptic Brain Mammalian Mitochondria (2000) (157)
- ADP-Regulation of Mitochondrial Free Radical Production Is Different with Complex I- or Complex II-Linked Substrates: Implications for the Exercise Paradox and Brain Hypermetabolism (1997) (154)
- Effect of Short-Term Caloric Restriction on H2O2 Production and Oxidative DNA Damage in Rat Liver Mitochondria and Location of the Free Radical Source (2001) (154)
- Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3. (1999) (145)
- Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: the pigeon and human case (1996) (144)
- Dietary Restriction at Old Age Lowers Mitochondrial Oxygen Radical Production and Leak at Complex I and Oxidative DNA Damage in Rat Brain (2005) (143)
- Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity (2007) (131)
- Protein Restriction Without Strong Caloric Restriction Decreases Mitochondrial Oxygen Radical Production and Oxidative DNA Damage in Rat Liver (2004) (130)
- A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat (1999) (130)
- Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls (2002) (125)
- Effect of thyroid status on lipid composition and peroxidation in the mouse liver. (1999) (122)
- Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals (2000) (121)
- Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction (2013) (115)
- A decrease of free radical production near critical targets as a cause of maximum longevity in animals. (1994) (112)
- Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver. (2007) (112)
- Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver (2008) (111)
- Maximum life span in vertebrates: Relationship with liver antioxidant enzymes, glutathione system, ascorbate, urate, sensitivity to peroxidation, true malondialdehyde, in vivo H2O2, and basal and maximum aerobic capacity (1993) (109)
- Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria. (2009) (107)
- Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver. (1994) (103)
- A comparative study of free radicals in vertebrates--II. Non-enzymatic antioxidants and oxidative stress. (1993) (103)
- Effects of fasting on oxidative stress in rat liver mitochondria (2006) (98)
- Simultaneous induction of sod, glutathione reductase, GSH, and ascorbate in liver and kidney correlates with survival during aging. (1993) (91)
- 8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging (1999) (86)
- A comparative study of free radicals in vertebrates--I. Antioxidant enzymes. (1993) (85)
- Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans. (2000) (85)
- Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse (1999) (82)
- Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans. (2008) (81)
- Membrane lipid unsaturation as physiological adaptation to animal longevity (2013) (81)
- The flux of free radical attack through mitochondrial DNA is related to aging rate (2000) (80)
- Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain. (2007) (80)
- Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice (2016) (79)
- Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart (2011) (79)
- Influence of hyper‐ and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle (2001) (76)
- Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart (2000) (72)
- Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain (2004) (71)
- Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals (2004) (70)
- Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate (2005) (68)
- Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice (2007) (68)
- Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart (2009) (65)
- Effect of Lipid Restriction on Mitochondrial Free Radical Production and Oxidative DNA Damage (2006) (63)
- Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential (2001) (62)
- An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms (2011) (61)
- Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage (2006) (60)
- Thyroid hormone-induced oxidative damage on lipids, glutathione and DNA in the mouse heart (2001) (60)
- Oxidative DNA damage estimated by oxo8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and alpha-tocopherol. (1997) (59)
- Plasma long-chain free fatty acids predict mammalian longevity (2013) (58)
- Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins. (1999) (56)
- Endotoxin increases oxidative injury to proteins in guinea pig liver: protection by dietary vitamin C. (1998) (56)
- Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria (2012) (56)
- Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage (2001) (55)
- Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver (2007) (55)
- Towards a unified mechanistic theory of aging (2019) (53)
- Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age. (2010) (52)
- Oxygen radicals, a failure or a success of evolution? (1993) (51)
- Short‐Term Caloric Restriction and Sites of Oxygen Radical Generation in Kidney and Skeletal Muscle Mitochondria (2004) (51)
- Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver (2008) (50)
- Increase in heart glutathione redox ratio and total antioxidant capacity and decrease in lipid peroxidation after vitamin E dietary supplementation in guinea pigs. (1996) (49)
- Vitamin E protects guinea pig liver from lipid peroxidation without depressing levels of antioxidants. (1995) (48)
- Effect of MPTP on brain mitochondrial H2O2 and ATP production and on dopamine and DOPAC in the striatum. (1999) (48)
- Testing the vicious cycle theory of mitochondrial ROS production: effects of H2O2 and cumene hydroperoxide treatment on heart mitochondria (2006) (47)
- Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain (2002) (44)
- Effect of time of restriction on the decrease in mitochondrial H2O2 production and oxidative DNA damage in the heart of food‐restricted rats (2002) (39)
- Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liver. (2008) (38)
- Endotoxin depletes ascorbate in the guinea pig heart. Protective effects of vitamins C and E against oxidative stress. (1996) (37)
- Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro (2011) (37)
- Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction (2015) (37)
- Longevity and antioxidant enzymes, non-enzymatic antioxidants and oxidative stress in the vertebrate lung: a comparative study (2004) (34)
- Relationship between lipid peroxidation, fatty acid composition, and ascorbic acid in the liver during carbohydrate and caloric restriction in mice. (1993) (32)
- Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria (2007) (31)
- Caloric and carbohydrate restriction in the kidney: Effects on free radical metabolism (1994) (29)
- The gene cluster hypothesis of aging and longevity (2008) (27)
- Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life-span of the rat (2001) (26)
- Effect of vitamin C on antioxidants, lipid peroxidation, and GSH system in the normal guinea pig heart. (1994) (26)
- Aging Rate, Mitochondrial Free Radical Production, and Constitutive Sensitivity to Lipid Peroxidation: Insights From Comparative Studies (2003) (24)
- Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity (2014) (24)
- Vitamin C, dehydroascorbate, and uric acid in tissues and serum: high-performance liquid chromatography. (1994) (24)
- Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats (2004) (22)
- Vitamin E decreases urine lipid peroxidation products in young healthy human volunteers under normal conditions. (1996) (21)
- Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum. (2002) (21)
- Effect of dietary vitamin C and catalase inhibition of antioxidants and molecular markers of oxidative damage in guinea pigs. (1994) (21)
- Long lifespans have evolved with long and monounsaturated fatty acids in birds (2015) (19)
- Role of Olive Oil and Monounsaturated Fatty Acids in Mitochondrial Oxidative Stress and Aging (2006) (19)
- Effect of dietary vitamin E levels on fatty acid profiles and nonenzymatic lipid peroxidation in the guinea pig liver (1996) (18)
- Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity (2020) (18)
- Phospholipid hydroperoxides and lipid peroxidation in liver and plasma of ODS rats supplemented with alpha-tocopherol and ascorbic acid. (1996) (18)
- Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction (2013) (17)
- Ascorbic acid and aging. (1996) (16)
- Estimation of the Rate of Production of Oxygen Radicals by Mitochondria (2006) (15)
- Aging Increases N epsilon -(Carboxymethyl)lysine and Caloric Restriction Decreases N epsilon -(Carboxyethyl)lysine and N epsilon -(Malondialdehyde)lysine in Rat Heart Mitochondrial Proteins (2002) (15)
- Mitochondrial oxidative stress and caloric restriction (2003) (14)
- Regulation of Membrane Unsaturation as Antioxidant Adaptive Mechanism in Long-lived Animal Species (2011) (13)
- [Calorie restriction, oxidative stress and longevity]. (2008) (12)
- The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice. (2010) (11)
- Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals (2020) (9)
- Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress (2014) (9)
- Is the NDUFV2 subunit of the hydrophilic complex I domain a key determinant of animal longevity? (2020) (9)
- Correlations with longevity and body size: to correct or not correct? (2014) (9)
- Free Radicals and Mammalian Aging (2009) (7)
- Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity (2020) (7)
- The role of DNA damage and repair in cell aging (2002) (7)
- Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8) (2016) (7)
- Elovl2-Ablation Leads to Mitochondrial Membrane Fatty Acid Remodeling and Reduced Efficiency in Mouse Liver Mitochondria (2021) (5)
- 8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and α-tocopherol (1997) (5)
- Mitochondrial Free Radical Production and Caloric Restriction: Implications in Vertebrate Longevity and Aging (2008) (4)
- Mammalian and bird aging, oxygen radicals, and restricted feeding (2004) (4)
- Localization in a Region of Complex I and Mechanism of the Higher Free Radical Production of Brain Nonsynaptic Mitochondria in the Short‐lived Rat Than in the Longevous Pigeon (1998) (4)
- The Cell Aging Regulation System (CARS) (2017) (3)
- Heart and Brain OXO8dG in the Genomic DNA of Rats and Pigeons and Maximum Longevity (1998) (3)
- Membrane peroxidation index and maximum lifespan are negatively correlated in fish of the genus Nothobranchius (2020) (3)
- Effect of early maternal adrenalectomy on antioxidant enzymes, GSH, ascorbate, and uric acid in the rat fetal lung at term. (1993) (2)
- Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius. (2020) (2)
- mTORC1 is also involved in longevity between species (2021) (2)
- Increase of life span of frogs after induction of SOD, GR, GSH and ascorbate (1990) (1)
- MITCHELL MEDAL LECTURE (2006) (1)
- Relationship between Fatty Acid Unsaturation, Sensitivity to Lipid Peroxidation, and Maximum Life Span in the Liver of Mammals (1998) (1)
- Short-term caloric and carbohydrate restriction increases GSH-Px and cytochrome oxidase and decreases ascorbate in the mouse kidney (1993) (1)
- [Effect of restricting amino acids except methionine on mitochondrial oxidative stress]. (2009) (1)
- Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals (2020) (1)
- Higher DNA repair in mitochondria of long-lived species (2021) (1)
- MITOCHONDRIAL ROS PRODUCTION AND THE UNIFIED THEORY OF PROGRAMMED AGING: THE ARS OF AGING (2020) (0)
- Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8) (2015) (0)
- Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector (2023) (0)
- Whole organism aging: Parabiosis, inflammaging, epigenetics, and peripheral and central aging clocks. The ARS of aging (2023) (0)
- Methionine Metabolism Is Down-Regulated in Heart of Long-Lived Mammals (2022) (0)
- Effects of beta-adrenergic signalling interruption with atenolol on mitochondrial ros production and oxidative stress in rat heart (2012) (0)
- A decrease of free radical production per unit oxygen consumption at critical sites can increase maximum longevity (1993) (0)
- Membrane peroxidation index and maximum lifespan are negatively correlated in fish of the genus <italic>Nothobranchius</italic> (2020) (0)
- Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction (2012) (0)
- Maximum longevity and five brain antioxidant enzymes, GSH, ascorbate, uric acid, GSSG/GSH, MDA (HPLC) and Tbars in vertebrate evolution including birds (1993) (0)
- Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity (2020) (0)
- HNE.P.12ß-adrenergic receptor signaling interruption with atenolol decreases peroxidizability index, protein lipoxidation levels and changes lipid related parameters linked to longevity (2012) (0)
- Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria (2012) (0)
- Programmed versus non-programmed evolution of aging. What is the evidence? (2023) (0)
- ROS The Cell Aging Regulation System ( CARS ) (2017) (0)
- The beta-1 receptor blocker atenolol increases mortality in a mammal in association with its depressing effects on heart function only in very old individuals: agreement with meta-analyses in hypertensive human patients? (2013) (0)
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Gustavo Barja is affiliated with the following schools:
