Guy Salvesen

Q: What Schools Are Affiliated With Guy Salvesen

Guy Salvesen is affiliated with the following schools: University of Cape Town, University of California, San Diego, Sanford Burnham Prebys Medical Discovery Institute, Purdue University, Duke University, University of Zurich

Guy Salvesen's AcademicInfluence.com Rankings

Guy Salvesen

Biology

#2580

World Rank

#4072

Historical Rank

Biochemistry

#330

World Rank

#400

Historical Rank

biology Degrees

Download Badge

Biology

Guy Salvesen's Degrees

Bachelors Biochemistry University of Cape Town
Masters Biochemistry University of Cape Town
PhD Biochemistry University of Cape Town

Why Is Guy Salvesen Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Guy Salvesen is a South African-born biochemist, best known for his work in the field of apoptosis. His research focuses on proteases and their inhibitors in humans, with particular emphasis on the caspases of the apoptotic cell death pathway.

(See a Problem?)

Guy Salvesen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. (1993) (4208)
Regulation of cell death protease caspase-9 by phosphorylation. (1998) (3357)
Human ICE/CED-3 Protease Nomenclature (1996) (2484)
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase (1995) (2244)
Caspases: Intracellular Signaling by Proteolysis (1997) (2143)
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling (2015) (2129)
X-linked IAP is a direct inhibitor of cell-death proteases (1997) (2085)
Human plasma proteinase inhibitors. (1983) (1920)
Apoptosis: IAP proteins: blocking the road to death's door (2002) (1847)
IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases (1998) (1509)
The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases (1997) (1412)
Mechanisms of caspase activation. (2003) (1364)
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. (1993) (1329)
The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins (2001) (1232)
An Induced Proximity Model for Caspase-8 Activation* (1998) (1128)
The apoptosome: signalling platform of cell death (2007) (1089)
Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis (2011) (1069)
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme (1992) (1038)
A unified model for apical caspase activation. (2003) (1011)
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis (2010) (939)
Caspase activation: the induced-proximity model. (1999) (922)
The protein structures that shape caspase activity, specificity, activation and inhibition. (2004) (855)
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family (2006) (811)
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. (1995) (788)
Pro-caspase-3 Is a Major Physiologic Target of Caspase-8* (1998) (787)
Structural Basis for the Inhibition of Caspase-3 by XIAP (2001) (786)
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases (1999) (780)
Human Caspases: Activation, Specificity, and Regulation* (2009) (708)
A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases* (1998) (652)
Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis (1997) (633)
Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract* (1998) (608)
Lysosomal Protease Pathways to Apoptosis (2001) (576)
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. (1999) (560)
Target Protease Specificity of the Viral Serpin CrmA (1997) (559)
The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases (1997) (550)
Caspase-9 Can Be Activated without Proteolytic Processing* (1999) (518)
Biochemical Characteristics of Caspases-3, -6, -7, and -8* (1997) (515)
Emerging principles in protease-based drug discovery (2010) (495)
Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3 (1997) (493)
Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling (1999) (487)
Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. (1986) (463)
Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins* (2004) (462)
Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis (1999) (446)
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. (2004) (442)
Dimer formation drives the activation of the cell death protease caspase 9 (2001) (436)
Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). (1990) (434)
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas (2000) (427)
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis (1998) (426)
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. (1990) (419)
An IAP-IAP Complex Inhibits Apoptosis* (2004) (413)
The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases* (2006) (404)
Properties of the caspases. (1998) (398)
XIAP inhibits caspase‐3 and ‐7 using two binding sites: evolutionarily conserved mechanism of IAPs (2005) (396)
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate. (1990) (383)
FLICE Induced Apoptosis in a Cell-free System (1997) (376)
A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor (2000) (375)
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. (1994) (360)
Caspases - controlling intracellular signals by protease zymogen activation. (2000) (356)
Regulation of the Apaf-1–caspase-9 apoptosome (2010) (344)
The Fas/FADD death domain complex structure unravels signaling by receptor clustering (2008) (343)
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. (1999) (342)
Caspases: keys in the ignition of cell death. (2002) (342)
Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues* (2008) (339)
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways (2008) (320)
Caspase substrates (2007) (317)
Activity-based probes that target diverse cysteine protease families (2005) (313)
The apoptosome activates caspase-9 by dimerization. (2006) (294)
Caspases: opening the boxes and interpreting the arrows (2002) (279)
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. (2000) (269)
Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A(*) (1995) (249)
Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and flies (2004) (248)
Activation of caspases-8 and -10 by FLIP(L). (2004) (238)
Structural basis for the activation of human procaspase-7 (2001) (223)
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. (1998) (221)
Regulated cell death: signaling and mechanisms. (2014) (213)
Kennedy's Disease (1999) (211)
Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases* (1996) (208)
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. (2011) (197)
Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. (1991) (197)
Catalytic properties of the caspases (1999) (189)
Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. (1987) (189)
Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation* (2010) (189)
Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases. (1986) (188)
Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis. (1992) (187)
Caspases and apoptosis. (2002) (187)
Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases (1997) (187)
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. (1996) (187)
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. (2002) (186)
Endogenous Inhibitors of Caspases (1999) (183)
Streptolysin O Promotes Group A Streptococcus Immune Evasion by Accelerated Macrophage Apoptosis* (2009) (178)
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death (1998) (176)
Ionomycin-activated Calpain Triggers Apoptosis (2002) (176)
Reprieval from execution: the molecular basis of caspase inhibition. (2002) (173)
Caspases: preparation and characterization. (1999) (171)
Caspase mechanisms. (2008) (165)
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. (2000) (164)
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. (2010) (162)
Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. (1989) (159)
Substrate specificities and activation mechanisms of matrix metalloproteinases. (1991) (157)
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. (2011) (156)
Caspase-14 Is a Novel Developmentally Regulated Protease* (1998) (153)
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis (2009) (152)
Granzyme B Mimics Apical Caspases (1998) (150)
Small Ubiquitin-related Modifier (SUMO)-specific Proteases (2007) (150)
Further characterization of the covalent linking reaction of alpha 2-macroglobulin. (1981) (148)
Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. (1997) (147)
Caspase substrates and inhibitors. (2013) (143)
Granzyme Release and Caspase Activation in Activated Human T-Lymphocytes* (1998) (141)
XIAP-mediated Caspase Inhibition in Hodgkin's Lymphoma–derived B Cells (2003) (141)
Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. (1991) (140)
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis (2002) (138)
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. (2005) (137)
Profiling constitutive proteolytic events in vivo. (2007) (136)
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia (2016) (136)
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling (2014) (132)
Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. (2000) (131)
Caspase activation. (2003) (124)
Comparative analysis of apoptosis and inflammation genes of mice and humans. (2003) (123)
Role of proteolysis in caspase-8 activation and stabilization. (2007) (123)
Structural and kinetic determinants of protease substrates (2009) (122)
Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis* (2001) (122)
Cleavage of Atrophin-1 at Caspase Site Aspartic Acid 109 Modulates Cytotoxicity* (1999) (121)
Neutralization of Smac/Diablo by Inhibitors of Apoptosis (IAPs) (2004) (120)
Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). (1991) (119)
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. (2019) (117)
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity (2011) (115)
Covalent binding of proteinases in their reaction with alpha 2-macroglobulin. (1980) (115)
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. (2006) (114)
Functions of caspase 8: the identified and the mysterious. (2014) (112)
Caspases on the brain (2002) (111)
Genomic organization and chromosomal localization of the human cathepsin G gene. (1989) (106)
Human Caspase-7 Activity and Regulation by Its N-terminal Peptide* (2003) (106)
Mitochondrial pathway of apoptosis is ancestral in metazoans (2012) (106)
Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. (1992) (104)
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. (2007) (103)
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. (1996) (102)
Caspase assays. (2000) (101)
Regulation of Histone Acetylation by Autophagy in Parkinson Disease* (2015) (100)
DeSUMOylating enzymes—SENPs (2008) (99)
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. (2012) (98)
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors* (2009) (92)
Distribution and paralogue specificity of mammalian deSUMOylating enzymes. (2010) (92)
A primer on caspase mechanisms. (2018) (92)
Identification of proteolytic cleavage sites by quantitative proteomics. (2007) (89)
Glycosylation Broadens the Substrate Profile of Membrane Type 1 Matrix Metalloproteinase* (2004) (89)
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. (2011) (89)
Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. (1993) (87)
Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. (1990) (84)
An unusual specificity in the activation of neutrophil serine proteinase zymogens. (1990) (84)
Primary structure of the reactive site of human C1-inhibitor. (1985) (82)
Intranasal Delivery of Caspase-9 Inhibitor Reduces Caspase-6-Dependent Axon/Neuron Loss and Improves Neurological Function after Stroke (2011) (81)
Mechanism and specificity of the human paracaspase MALT1 (2012) (77)
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. (2009) (77)
Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites. (1989) (75)
Apoptosome: the seven-spoked death machine. (2002) (74)
Protease signaling in animal and plant‐regulated cell death (2016) (74)
Granzyme B Mimics Apical Caspases DESCRIPTION OF A UNIFIED PATHWAY FOR TRANS-ACTIVATION OF EXECUTIONER CASPASE-3 AND -7* (1998) (73)
Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3 (2002) (72)
Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils. (2017) (72)
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. (2005) (71)
The Dynamics and Mechanism of SUMO Chain Deconjugation by SUMO-specific Proteases* (2011) (69)
Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum (2012) (69)
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. (2004) (68)
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release (2019) (66)
TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis* (2001) (66)
Apoptotic caspase activation and activity. (2008) (66)
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates (2014) (65)
A lysosomal protease enters the death scene. (2001) (65)
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity (2017) (65)
Small Molecule Active Site Directed Tools for Studying Human Caspases. (2015) (64)
Activation and specificity of human caspase-10. (2010) (62)
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. (2011) (62)
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1 (2018) (61)
Sequential Autolytic Processing Activates the Zymogen of Arg-gingipain* (2003) (60)
Investigation of glucocorticoid-induced apoptotic pathway: Processing of Caspase-6 but not Caspase-3 (1998) (60)
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. (2006) (59)
Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. (1989) (59)
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation (2004) (59)
Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors as Guardians and Regulators (2005) (57)
Activation and substrate specificity of caspase-14. (2004) (57)
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). (2008) (57)
Crystal structure of the apoptotic suppressor CrmA in its cleaved form. (2000) (57)
Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris. (1992) (57)
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. (2010) (56)
Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4) (2010) (55)
Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates (2014) (54)
The mechanism of peptide-binding specificity of IAP BIR domains (2008) (52)
Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function* (2008) (52)
In vivo catabolism of α1-antichymotrypsin is mediated by the Serpin receptor which binds α1-proteinase inhibitor, antithrombin III and heparin cofactor II (1988) (51)
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. (2007) (51)
Stepwise activation mechanisms of the precursors of matrix metalloproteinases 1 (tissue collagenase) and 3 (stromelysin). (1991) (50)
An optimized activity-based probe for the study of caspase-6 activation. (2012) (50)
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. (2003) (50)
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04303a (2018) (50)
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. (2020) (49)
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC (2008) (48)
Caspase 8: igniting the death machine. (1999) (48)
Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis. (2001) (47)
Cathepsin D Primes Caspase-8 Activation by Multiple Intra-chain Proteolysis* (2012) (47)
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. (2004) (47)
Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4 (2015) (46)
Expression, Purification, and Characterization of Caspases (2002) (45)
Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor* (2009) (45)
Metacaspases are not caspases – always doubt (2010) (45)
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. (2011) (44)
Viral caspase inhibitors CrmA and p35. (2000) (43)
alpha-Macroglobulins: detection and characterization. (1993) (43)
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases. (2002) (43)
Carboxyl-terminal Proteolytic Processing of CUX1 by a Caspase Enables Transcriptional Activation in Proliferating Cells* (2007) (43)
Programmed cell death and the caspases (1999) (43)
Neutrophil elastase and cathepsin G: structure, function, and biological control. (1988) (42)
Engineered hybrid dimers: tracking the activation pathway of caspase-7. (2006) (42)
National Academy of Sciences colloquium “ Proteolytic Processing and Physiological Regulation , ” held February 20 – 21 , 1999 , at the Arnold and Mabel Beckman Center in Irvine , CA . Caspase activation : The induced-proximity model (1999) (41)
Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion (2011) (39)
Characteristics of the caspase-like catalytic domain of human paracaspase (2004) (38)
Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery. (2018) (38)
Structure of the Fas/FADD complex: A conditional death domain complex mediating signaling by receptor clustering (2009) (37)
Caspase assays: identifying caspase activity and substrates in vitro and in vivo. (2008) (37)
Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. (2016) (37)
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families (2017) (37)
Caspase selective reagents for diagnosing apoptotic mechanisms (2019) (37)
Rapid isolation of human kininogens. (1987) (36)
Mechanism-based inactivation of caspases by the apoptotic suppressor p35. (2001) (35)
Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma. (1994) (35)
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6 (2012) (35)
Inhibitor specificity of recombinant and endogenous caspase-9. (2002) (35)
Yersinia Phosphatase Induces Mitochondrially Dependent Apoptosis of T Cells* (2005) (33)
Glycine Fluoromethylketones as SENP‐Specific Activity Based Probes (2012) (33)
Small molecules not direct activators of caspases (2007) (33)
Nicotinamide Rescues Human Embryonic Stem Cell‐Derived Neuroectoderm from Parthanatic Cell Death (2009) (33)
The Paracaspase MALT1. (2016) (31)
Cytokine Response Modifier A Inhibition of Initiator Caspases Results in Covalent Complex Formation and Dissociation of the Caspase Tetramer* (2006) (30)
Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases. (1991) (29)
Structure of inter-alpha-inhibitor (inter-alpha-trypsin inhibitor) and pre-alpha-inhibitor: current state and proposition of a new terminology. (1990) (28)
cDNA encoding a human homolog of yeast ubiquitin 1 (1987) (28)
X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. (2012) (28)
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy (2020) (27)
[21] Human kininogens (1988) (27)
Inhibition of distant caspase homologues by natural caspase inhibitors. (2001) (27)
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. (2013) (27)
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide (2019) (26)
Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress (2011) (26)
Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA. (1996) (25)
An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with alpha 2-antiplasmin. (1993) (25)
Identification of very potent inhibitor of human aminopeptidase N (CD13). (2010) (25)
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00997c (2019) (25)
Serpin α1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy (1996) (25)
Caspase enzymology and activation mechanisms. (2014) (24)
INTERACTION OF α2‐MACROGLOBULIN WITH NEUTROPHIL AND PLASMA PROTEINASES (1983) (24)
Interaction of subtilisins with serpins (1996) (23)
The proteasome as a drug target in the metazoan pathogen, Schistosoma mansoni. (2019) (23)
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11 (2020) (23)
Probes to monitor activity of the paracaspase MALT1. (2015) (22)
Proteases and the regulation of biological processes (2003) (22)
SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML (2015) (22)
Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom (2016) (21)
Multiplexed probing of proteolytic enzymes using mass cytometry-compatible activity-based probes. (2020) (20)
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. (2012) (19)
A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids (2014) (19)
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking. (2007) (19)
In vivo catabolism of alpha 1-antichymotrypsin is mediated by the Serpin receptor which binds alpha 1-proteinase inhibitor, antithrombin III and heparin cofactor II. (1988) (18)
Expression of a functional α‐macroglobulin receptor binding domain in Escherichia coli (1992) (17)
Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells (2019) (17)
Human kininogens. (1988) (16)
Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor: synthesis of polyethylene glycol conjugates with improved therapeutic potential. (1990) (16)
Control of coagulation and fibrinolysis by plasma proteinase inhibitors. (1983) (16)
N-terminomics: a high-content screen for protease substrates and their cleavage sites. (2011) (15)
Molecular cloning of human neutrophil elastase. (1988) (15)
The CULt of Caspase-8 Ubiquitination (2009) (15)
Targeting activated integrin αvβ3 with patient-derived antibodies impacts late-stage multiorgan metastasis (2010) (15)
Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections (2021) (14)
NETosis Occurs Independently of Neutrophil Serine Proteases. (2020) (14)
Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation* (2014) (14)
Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes (2018) (13)
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion (2020) (13)
α1-Microglobulin Destroys the Proteinase Inhibitory Activity of α1-Inhibitor-3 by Complex Formation (*) (1995) (13)
Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L* (2012) (12)
Caspase inhibition, specifically. (2007) (12)
The human neutrophil elastase gene. Analysis of the nucleotide sequence reveals three distinct classes of repetitive DNA. (1989) (12)
Caspases and Neuronal Development (2003) (12)
Aza-Peptide Epoxides: A New Class of Inhibitors Selective for Clan CD Cysteine Proteases (2003) (11)
Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes (2019) (11)
Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region. (1983) (11)
Transferring death: a role for tRNA in apoptosis regulation. (2010) (11)
Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation (2017) (11)
Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody (2020) (10)
A second cytotoxic proteolytic peptide derived from β-amyloid precursor protein (2000) (10)
Symmetry of the inhibitory unit of human alpha 2-macroglobulin. (1988) (10)
Comparison of the Structure and Aspects of the Proteinase-Binding Properties of Cystic Fibrotic α2-Macroglobulin with Normal α2-Macroglobulin (1982) (9)
The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase. (1990) (8)
Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe (2019) (8)
Caspase mechanisms in the regulation of inflammation. (2022) (7)
Dying from within: granzyme B converts entosis to emperitosis (2013) (7)
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. (2004) (7)
Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells (2019) (7)
Complementary roles of FADD and RIPK3 in T cell homeostasis and antiviral immunity (163.24) (2012) (7)
Polyethylene glycol modification of serpins improves therapeutic potential. (1990) (7)
Chemical ligation--an unusual paradigm in protease inhibition. (2006) (5)
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi* (2015) (5)
Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe. (2019) (5)
Interaction of plasma kallikrein with plasma proteinase inhibitors. (1983) (5)
Interaction of alpha 2-macroglobulin with neutrophil and plasma proteinases. (1983) (5)
The Nematode Death Machine in 3D (2005) (5)
NETosis occurs independently of neutrophil serine proteases. (2020) (4)
Proteolytic needles in the cellular haystack. (2008) (4)
Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7. (2021) (4)
Polypeptide Chain Structure of Inter-α-Trypsin Inhibitor and Pre-α-Trypsin Inhibitor: Evidence for Chain Assembly by Glycan and Comparison with other “Kunin”-Containing Proteins (1990) (4)
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors (2020) (4)
Serpins and programmed cell death. (1997) (3)
Caspases and Their Natural Inhibitors as Therapeutic Targets for Regulating Apoptosis (2000) (3)
Identification of Protease Substrates by Mass Spectrometry Approaches-1 (2008) (3)
Further characterization of the covalent linking reaction of a2-macroglobulin (2005) (3)
Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death. (2017) (3)
Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions. (2005) (3)
apoptosis by a mechanism requiring receptor proteolysis (1998) (3)
In Vitro Expression of Serpins (1994) (3)
CHAPTER 182 – Caspases: Cell Signaling by Proteolysis (2003) (2)
Evolutionary loss of inflammasomes in carnivores to facilitate carriage of zoonotic infections (2020) (2)
Caspases (2001) (2)
Caspases,Paracaspases, and Metacaspases (2014) (2)
The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes) (2019) (2)
Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli. (1992) (1)
Inhibition of Interleukin-lP Converting Enzyme by the Cowpox Virus Serpin (2001) (1)
Cloning of a bovine protein homologous with cysteine proteinases and identification of the gene (1986) (1)
A novel caspase-7 specific monoclonal antibody. (2005) (1)
Cystatin-like domains of LMW-kininogen, and speculations on the evolution of cystatins (1986) (1)
Response to Comment on “SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML” (2016) (1)
Identification and Evaluation of Novel Small Molecule Pan-Caspase Inhibitors in Huntington’s Disease Models (2011) (1)
Caspases: Intracellular Minireview Signaling by Proteolysis (1997) (1)
Comparison of the structure and aspects of the proteinase-binding properties of cystic fibrotic alpha-macroglobulin with normal alpha 2-macroglobulin. (1982) (1)
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold (2022) (1)
UNIT 21.8 Caspases (2002) (1)
Chapter 588 – Cathepsin G (2013) (1)
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. (2014) (1)
Biochemical Society Symposium: Preface (2003) (0)
Mousing around with caspases and IAPs. (2012) (0)
Caspases Mediate Pannexin 1 Channel Activation in Apoptotic Cells (2011) (0)
Proteolytic activation of the cell death protease Yama / CPP 32 by granzyme B ( apoptosis / interleukin 1 p-converting enzyme ) (2005) (0)
Divide and die another day. (2010) (0)
Types and families of endopeptidases (2009) (0)
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion (2020) (0)
Caspases: Keys in the Ignition of Cell Death (2003) (0)
Serpins are getting hotter. (2003) (0)
Membrane-Mediated Conformational Changes of Cytoprotective BCL-Xl Regulate its Activity (2020) (0)
The Structure of the BIR domain of IAP-like protein 2 (2004) (0)
The role of zymogenicity in caspase activation: How to trigger programmed cell death (2002) (0)
Caspase-8 and Caspase-10 (2013) (0)
A tribute to Alan J. Barrett. (2003) (0)
Structure of cleaved, CARD domain deleted Caspase-9 (2001) (0)
Cytosolic protease cascades: activation by granzymes (1997) (0)
Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors. (2006) (0)
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel Lindau syndrome. (2022) (0)
Methods to detect Alzheimer's disease. (1993) (0)
Immunohistochemical profiling of caspases in a mouse model of Retinal Vein Occlusion (RVO) (2019) (0)
Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells (2019) (0)
Faculty Opinions recommendation of NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. (2011) (0)
Determining ocular HtrA1 activity and inhibition using novel activity based probe (2018) (0)
Highlight: The universe of proteolytic networks and mechanisms (2012) (0)
Apoptosis: Human Caspases – Apoptosis and Inflammation Signaling Proteases (2011) (0)
Critical Review (1982) (0)
Faculty Opinions recommendation of Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2. (2011) (0)
Fasci 1..11 (2015) (0)
Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac (2004) (0)
Crystal Structure of the Caspase-7 / XIAP-BIR2 Complex (2002) (0)
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide (2019) (0)
Comprar Protein Discovery Technologies | Renata Pasqualini | 9780824754686 | Informa Healthcare (2007) (0)
HUMAN PRO-APOPTOTIC PROTEIN BID (2000) (0)
In memoriam: Prof Christopher J Froelich (1951–2015) (2015) (0)
ID: 152 Proteolytic pathways in cell death (2006) (0)
Topical OT-717 confers superior retinal protection compared to intravitreal anti-VEGF in mouse retinal vein occlusion model (2019) (0)
Caspases: cytokine activators and promoters of cell death (1999) (0)
Histone deacetylase 7 is a caspase-8 substrate (2007) (0)
Science Signaling Podcast: 9 June 2015 (2015) (0)
Caspase-9 inhibition by Pen1-XBir3 abrogates retinal edema (2016) (0)
Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes (2018) (0)
Natural caspase inhibitors (2007) (0)
The trap hypothesis: alpha2M and protease inhibition (2006) (0)
Biochemical Society Symposium: 70 (2003) (0)
ID: 237 Substrate profiling of the Clan CE proteases (2006) (0)
The trap hypothesis: α2M and protease inhibition (2006) (0)
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion (2020) (0)
Identification of protease cleavage-sites in E. coli lysate by differential N-terminomic analysis (2009) (0)
STRUCTURE OF THE VIRAL SERPIN CRMA (2000) (0)
Essential pro-survival role for caspase-8 during T-cell activation and embryonic development through inhibition of RIPK3-dependent necrosis (159.9) (2011) (0)
Therapeutic eyedrops inhibiting caspase-9 reduce edema and protect retinal function in mouse model of RVO (2018) (0)
CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3 (2001) (0)
Caspase-9 Inhibitor Eyedrops Reduce Edema and Protect Retinal Function Following Central Retinal Vein Occlusion (2017) (0)
Paralog specificity of mammalian SENPs for SUMO‐1 and SUMO‐2 (2008) (0)
Molecular biology of cysteine proteases predictions for intracellular catabolism (1986) (0)
Structure Previews Caspase Inhibition , Specifically (0)
Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells (2019) (0)
A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids (2014) (0)
Smallpox protease K 7 L 1 Activity , Specificity and Probe Design for the Smallpox Virus Protease K 7 L (2012) (0)
Caspase selective reagents for diagnosing apoptotic mechanisms (2018) (0)
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion (2020) (0)
Proteinase Inhibitors: An Overview of their Structure and Possible Function in the Acute Phase (2020) (0)
Crystal structure of Pseudo-activated Procaspase-3 (2010) (0)
Engineering caspase 7 as an affinity reagent to capture proteolytic products (2020) (0)

This paper list is powered by the following services:

Other Resources About Guy Salvesen

en.wikipedia.org

What Schools Are Affiliated With Guy Salvesen?

Guy Salvesen is affiliated with the following schools:

Guy Salvesen's Academic­Influence.com Rankings