H. A. Len Fozzard

H. A. Len Fozzard's AcademicInfluence.com Rankings

H. A. Len Fozzard

Philosophy

#5828

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#8738

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Logic

#3038

World Rank

#4134

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philosophy Degrees

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Philosophy

H. A. Len Fozzard's Degrees

Masters Medicine University of Oxford
PhD Cardiology University of Oxford

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H. A. Len Fozzard's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The heart and cardiovascular system (1986) (894)
AZTEC, a preprocessing program for real-time ECG rhythm analysis. (1968) (394)
A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties (1992) (371)
Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development (1982) (339)
Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms. (1996) (311)
Increase in Intracellular Sodium Ion Activity during Stimulation in Mammalian Cardiac Muscle (1982) (282)
Ca and Na selectivity of the active membrane of rabbit AV nodal cells. (1979) (278)
Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: experience in 26 cases. (1982) (266)
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. (1994) (245)
Afterdepolarizations and triggered activity. (1992) (220)
Activities of potassium and sodium ions in rabbit heart muscle (1975) (209)
The Heart and cardiovascular system : scientific foundations (1986) (188)
Delayed afterdepolarizations in heart muscle: mechanisms and relevance. (1988) (181)
KcsA crystal structure as framework for a molecular model of the Na(+) channel pore. (2000) (175)
Characteristics of L- and T-type Ca2+ currents in canine cardiac Purkinje cells. (1989) (174)
Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels (2005) (170)
Mechanism of local anesthetic drug action on voltage-gated sodium channels. (2005) (169)
The positive dynamic current and its inactivation properties in cardiac Purkinje fibres (1973) (162)
Membrane capacity of the cardiac Purkinje fibre (1966) (153)
Strength—duration curves in cardiac Purkinje fibres: effects of liminal length and charge distribution (1972) (140)
Phosphorylation restores activity of L‐type calcium channels after rundown in inside‐out patches from rabbit cardiac cells. (1992) (130)
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells. (1987) (122)
Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. (1993) (122)
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. (1998) (117)
The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel (2010) (116)
Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family. (2008) (115)
Sodium channel selectivity filter regulates antiarrhythmic drug binding. (1997) (112)
Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore (2010) (106)
Heart: excitation-contraction coupling. (1977) (101)
Nonlinear Relation Between ±max and INa in Canine Cardiac Purkinje Cells (1988) (100)
A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. (1995) (100)
The Effects of Membrane Potential, Extracellular Potassium, and Tetrodotoxin on the Intracellular Sodium Ion Activity of Sheep Cardiac Muscle (1984) (98)
Slow inward current and contraction of sheep cardiac Purkinje fibers (1975) (97)
Adrenergic Modulation of the Transient Outward Current in Isolated Canine Purkinje Cells (1988) (97)
μ-Conotoxin Giiia Interactions with the Voltage-Gated Na+ Channel Predict a Clockwise Arrangement of the Domains (2000) (93)
Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule. (1999) (89)
Changes in intracellular Ca2+ activity with stimulation in sheep cardiac Purkinje strands. (1982) (89)
Two phosphatase sites on the Ca2+ channel affecting different kinetic functions. (1993) (88)
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII. (1992) (88)
The Sodium Channel as a Target for Local Anesthetic Drugs (2011) (87)
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells (1990) (86)
Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis. (1998) (85)
Electrostatic and Steric Contributions to Block of the Skeletal Muscle Sodium Channel by μ-Conotoxin (2002) (85)
Charge at the lidocaine binding site residue Phe‐1759 affects permeation in human cardiac voltage‐gated sodium channels (2007) (85)
Voltage Dependence and Time Dependence of Contraction in Sheep Cardiac Purkinje Fibers (1971) (79)
The relation of Vmax to INa, GNa, and h infinity in a model of the cardiac Purkinje fiber. (1979) (77)
Relation between Intracellular Sodium and Twitch Tension in Sheep Cardiac Purkinje Strands Exposed to Cardiac Glycosides (1983) (75)
New studies of the excitatory sodium currents in heart muscle. (1985) (73)
ST-segment potentials and mapping. Theory and experiments. (1976) (73)
Intra‐and Extracellular K+ and Na+ Activities and Resting Membrane Potential in Sheep Cardiac Purkinje Strands (1980) (70)
Membrane response to current pulses in spheroidal aggregates of embryonic heart cells (1975) (70)
Sodium channel molecular conformations and antiarrhythmic drug affinity. (2010) (70)
Is there a second external lidocaine binding site on mammalian cardiac cells? (1989) (69)
Influence of changes in external potassium and chloride ions on membrane potential and intracellular potassium ion activity in rabbit ventricular muscle (1976) (68)
Functional expression of the rat heart I Na+ channel isoform Demonstration of properties characteristic of native cardiac Na+ channels (1990) (68)
Molecular modeling of interactions of dihydropyridines and phenylalkylamines with the inner pore of the L-type Ca2+ channel. (2003) (67)
Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block (2002) (67)
Effect of stretch on conduction velocity and cable properties of cardiac Purkinje fibers. (1979) (66)
Cellular mechanism of action of cardiac glycosides. (1985) (65)
Modeling of the outer vestibule and selectivity filter of the L-type Ca2+ channel. (2001) (64)
Catecholamine effects on intracellular sodium activity and tension in dog heart. (1982) (63)
Relationships between voltage and tension in sheep cardiac Purkinje fibers (1975) (62)
Using Lidocaine and Benzocaine to Link Sodium Channel Molecular Conformations to State-Dependent Antiarrhythmic Drug Affinity (2009) (61)
The voltage clamp and cardiac electrophysiology. (1975) (60)
Effects of imipramine on cellular electrophysiological properties of cardiac Purkinje fibers. (1979) (60)
Voltage-gated Na Channel Selectivity: The Role of the Conserved Domain III Lysine Residue (2008) (59)
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. (2000) (58)
The Selectivity Filter of the Voltage-gated Sodium Channel Is Involved in Channel Activation* (2001) (57)
The conducted action potential. Models and comparison to experiments. (1983) (57)
Open sodium channel properties of single canine cardiac Purkinje cells. (1987) (55)
Intracellular chloride activity in mammalian ventricular muscle. (1981) (55)
Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin- resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction (1993) (53)
Relationship between lipid fluidity and water permeability of bovine tracheal epithelial cell apical membranes. (1986) (50)
Surgical treatment of recurrent primary malignant tumor of the left atrium. (1979) (49)
Inactivation properties of T-type calcium current in canine cardiac Purkinje cells. (1989) (49)
High Potassium and Low Sodium Contractures in Sheep Cardiac Muscle (1971) (49)
Effects of Tonicity on Tension and Intracellular Sodium and Calcium Activities in Sheep Heart (1984) (48)
Na,K pump stimulation by intracellular Na in isolated, intact sheep cardiac Purkinje fibers (1988) (48)
Cardiac muscle: excitability and passive electrical properties. (1977) (47)
Effect of diameter on membrane capacity and conductance of sheep cardiac Purkinje fibers (1975) (44)
The inhibitory effects of K+ channel-blocking agents on T lymphocyte proliferation and lymphokine production are "nonspecific". (1987) (43)
Isoform‐dependent interaction of voltage‐gated sodium channels with protons (2006) (42)
Gating currents associated with Na channels in canine cardiac Purkinje cells (1990) (42)
Action potential and contraction of heart muscle. (1973) (41)
Relationship between Membrane Voltage and Tension in Voltage-clamped Cardiac Purkinje Fibres (1968) (40)
Fab fragments of digoxin-specific antibodies used to reverse ventricular fibrillation induced by digoxin ingestion in a child. (1982) (40)
The electrophysiology of acute myocardial ischemia. (1985) (39)
A structural motif for the voltage-gated potassium channel pore. (1995) (38)
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics. (2001) (37)
Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. (2001) (37)
Experimental study of the conducted action potential in cardiac Purkinje strands. (1983) (36)
Sarcolemmal evaginations with knob-like or stalked projections in Purkinje fibers of the sheep's heart. (1969) (36)
Low conductance sodium channels in canine cardiac Purkinje cells. (1987) (36)
Interaction between Fast and Ultra-slow Inactivation in the Voltage-gated Sodium Channel (2002) (35)
Myocardial injury in burn shock. (1961) (35)
A Model of Scorpion Toxin Binding to Voltage-gated K+ Channels (1997) (34)
Accuracy of a Continuous Real‐Time ECG Dysrhythmia Monitoring System (1974) (34)
Influence of Potassium Ions and Osmolality on the Resting Membrane Potential of Rabbit Ventricular Papillary Muscle with Estimation of the Activity and the Activity Coefficient of Internal Potassium (1975) (33)
Cardiac-Specific External Paths for Lidocaine, Defined by Isoform-Specific Residues, Accelerate Recovery From Use-Dependent Block (2001) (32)
Excitation-contraction coupling in the heart. (1991) (32)
Suppression of ventricular arrhythmias with intravenous disopyramide and lidocaine: efficacy comparison in a randomized trial. (1979) (31)
Localization of Tritiated ‘Digoxin’ in the Myocardial Cells of Frogs and Dogs by Autoradiography Combined with Electron Microscopy (1963) (30)
Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel. (2004) (30)
Modal behavior of the mu 1 Na+ channel and effects of coexpression of the beta 1-subunit. (1996) (30)
Effect of Formaldehyde and Glutaraldehyde on Electrical Properties of Cardiac Purkinje Fibers (1969) (29)
The cloned cardiac Na channel α-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels (1992) (29)
Tetrodotoxin sensitivity in the developing and adult chick heart. (1981) (28)
Cardiac sodium and calcium channels: a history of excitatory currents. (2002) (28)
Regulation of Intracellular Sodium Concentrations in Rat Diaphragm Muscle (1967) (28)
External site for local anesthetic block of cardiac Na+ channels. (1991) (28)
Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels. (2005) (27)
Intracellular potassium and sodium activities of chick ventricular muscle during embryonic development. (1980) (26)
New approaches to antiarrhythmic therapy; emerging therapeutic applications of the cell biology of cardiac arrhythmias. (2001) (25)
Electrophysiology of Cl secretion in canine trachea (2005) (25)
Membrane permeability during low potassium depolarization in sheep cardiac Purkinje fibers. (1979) (25)
Electromechanical dissociation and its possible role in sudden cardiac death. (1985) (25)
Membrane ionic conductances during rest and activity in guinea pig atrial muscle. (1967) (24)
A real-time pressure algorithm. (1981) (23)
Voltage and time dependence of restitution in heart. (1982) (23)
2 – CAPACITIVE, RESISTIVE, AND SYNCYTIAL PROPERTIES OF HEART MUSCLE—ULTRASTRUCTURAL AND PHYSIOLOGICAL CONSIDERATIONS (1973) (23)
Excitation‐Contraction Coupling and Digitalis (1973) (22)
The saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field. (1994) (22)
OBSERVATIONS ON THE LOCALIZATION OF TRITIATED DIGOXIN IN MYOCARDIAL CELLS BY AUTORADIOGRAPHY AND ULTRAMICROSCOPY: WITH ADDED REFERENCE TO THE SARCOTUBULAR SYSTEM STUDIED BY CELL FRACTIONATION AND ENZYME STAINING. (1965) (21)
The influence of intercellular clefts on the electrical properties of sheep cardiac Purkinje fibers. (1979) (21)
Effects of Ca2+/Mg2+ removal on aiNa, aiK, and tension in cardiac Purkinje fibers. (1986) (21)
Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids. (1994) (20)
Validity of Myocardial Infarction Models (1975) (20)
A Molecular Switch between the Outer and the Inner Vestibules of the Voltage-gated Na+ Channel* (2010) (20)
Do Defects in Ion Channel Glycosylation Set the Stage for Lethal Cardiac Arrhythmias? (2002) (19)
Cellular basis for inotropic changes in the heart. (1988) (19)
Intra‐ and Extracellular Potassium Activities, Acetylcholine and Resting Potential in Guinea Pig Atria (1984) (18)
New approaches to antiarrhythmic therapy: emerging therapeutic applications of the cell biology of cardiac arrhythmias(1). (2001) (18)
The cellular mechanism of active chloride secretion in vertebrate epithelia: studies in intestine and trachea. (1982) (17)
Diodrast (I131) whole blood clearance as an index of renal blood flow (1964) (16)
Modulation of the cardiac transient outward current by catecholamines. (1989) (16)
Mechanism of Cl secretion in canine trachea: Changes in intracellular chloride activity with secretion (2005) (15)
Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels. (2015) (15)
An Adenosine Triphosphatase Preparation from a Membrane‐Sarcotubular Fraction of Guinea Pig Heart Muscle (1964) (15)
A cleft model for cardiac Purkinje strands. (1981) (15)
Na/Ca exchange in the intact cardiac cell (1985) (14)
A direct effect of forskolin on sodium channel bursting (1995) (14)
Slow Inward Current and Contraction (1980) (14)
Unitary conductance of Na+ channel isoforms in cardiac and NB2a neuroblastoma cells. (1995) (13)
Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door? (2007) (13)
The guanidinium toxin binding site on the sodium channel. (1996) (13)
Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells. (1988) (13)
Measurement of intracellular calcium ion activity with neutral exchanger ion sensitive microelectrodes. (1985) (12)
Depolarizing effects of catecholamines in quiescent sheep cardiac Purkinje fibers. (1986) (12)
Single channel sodium current in rat cardiomyocytes: use-dependent block by ethacizin. (1989) (11)
Mechanism of acute erythrocyte loss following burn. (1960) (11)
Electrophysiological effects of imipramine on cardiac Purkinje fibers (1978) (11)
Sodium currents in single cardiac Purkinje cells. (1986) (10)
Changes in intracellular sodium with chloride secretion in dog tracheal epithelium. (1986) (10)
Liver function following thermal injury. (1960) (9)
Sodium channels in cardiac Purkinje cells (1987) (9)
A medical information system for the coronary care unit. (1974) (8)
Gap Junctions and Liminal Length in Hypertrophy: Something Old and Something New (2001) (8)
Electrochemical properties of hydrated cation-selective glass membrane. A model of K+ and Na+ transport. (1974) (8)
Therapeutic uses of calcium-blocking agents:verapamil, nifedipine, and diltiazem. (1981) (8)
Computers for recognition and management of arrhythmias. (1976) (7)
University of Wisconsin solution preserves myocardial calcium current response to isoproterenol in isolated canine ventricular myocytes. (1995) (7)
Mechanisms of pharmacologic intervention at the level of the calcium channel. (1992) (6)
Chapter 8 – The Membrane Capacitance of Heart Cells (1972) (6)
Ion channels and pumps in cardiac function. (1995) (6)
Ventricular arrhythmias associated with CNS disease. (1982) (6)
Digital computer analysis of M‐scan echocardiograms (1976) (6)
THE RELATION OF Vmax TO INa, GNa, AND h. IN A MODEL OF THE CARDIAC PURKINJE FIBER (2005) (6)
A molecular model of the inner pore of the Ca channel in its open state (2011) (5)
7 – Some Experimental Studies of Na–Ca Exchange in Heart Muscle (1986) (4)
6 Voltage-Gated Sodium Channels (2006) (4)
Fifty years of cardiovascular science together. (2003) (4)
A dual-processor computer for arrhythmia analysis. (1978) (4)
Use of levarterenol in treatment of irreversible hemorrhagic shock. (1959) (4)
Oita International Electrocardiology Symposium 2000 “Electrophysiology and Management of Lethal Arrhythmias in the New Millennium: From Genes to Bedside” (2000) (4)
Quinidine Reduces Outward Current in Single Canine Cardiac Purkinje Cells (1987) (3)
Electrophysiology of the heart: the effects of ischemia. (1980) (3)
How do cardiac cells die? (1976) (2)
Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Na Channels (2005) (2)
Computer handling of coronary care unit data. (1973) (2)
Intracellular Calcium: Its Universal Role as Regulator By Anthony K. Campbell (review) (2015) (2)
Intracellular K + Activity of Cardiac Purkinje Fibers During Temperature Change (1981) (2)
Current understanding of the structure of the voltage-gated sodium channel (1996) (2)
Channel‐Specific Therapy of Cardiac Arrhythmias in Our Time? (2000) (2)
The resting potential in heart muscle. (1982) (2)
Quinidine reduces outward current in single purkinje cells of the canine heart (1986) (2)
Electrophysiology and the electrocardiogram. (1975) (2)
TREATMENT OF SEVERE THERMAL BURNS WITH DIGOXIN AND INTRAVENOUS FLUIDS (1959) (1)
Increased sensitivity to local anesthetic drugs: bedside to bench. (2008) (1)
Ion Channels and Cardiac Arrhythmia in Heart Disease (2011) (1)
History of Basic Science in Cardiac Electrophysiology (2011) (1)
ACUTE BLOOD VOLUME CHANGES FOLLOWING FLASH BURN (1958) (1)
Calcium channel blocking drugs. Part I: The calcium channel. (1985) (1)
Molecular modeling of scorpion toxin binding to voltage-gated K+ channels (1999) (1)
Chapter 25 Cardiac glycosides (1997) (1)
Voltage-Gated Sodium Channels (2007) (1)
The Past and Promise of Basic Cardiac Electrophysiology (2008) (1)
State-Dependent Block of Cardiac Na Currents by Ca Channel Antagonists (1989) (1)
Role for Sodium Channels and Intracellular Sodium in Regulation of the Cardiac Force-Frequency Relation and Contractility (1990) (1)
Cytosolic Sodium Ion Activity in Heart Cells (1985) (1)
Comparison of saxitoxin binding to mammalian heart TTX-resistant and brain TTX-sensitive sodium channels (1990) (1)
17th Bethesda conference: Adult cardiology training. Task Force VIII: Training in cardiovascular research. (1986) (0)
Charge at the local anesthetic binding site modulates steady state inactivation of voltage gated Na channels (2007) (0)
Structural determinants of TTX block using point mutations of cloned Na channels (1992) (0)
Calcium channel blocking drugs. Part II: Clinical applications. (1985) (0)
A Model of the Inner Pore of Ca Channels in the Open State (2011) (0)
A Guinea Pig's History of Biology (review) (2009) (0)
Structure of the sodium channel pore deduced from interaction with local anesthetic antiarrhythmic drugs. (1999) (0)
Radiogram for determination of cardiac output. Comparison with Evans blue dye dilution method. (1960) (0)
In Memoriam: Morton Arnsdorf (2010) (0)
DIODRAST (I-131) WHOLE BLOOD CLEARANCE AS AN INDEX OF RENAL BLOOD FLOW. (1964) (0)
Physiology of the Heart.Arnold M. Katz (1993) (0)
Electrocardiography and electrophysiology are (or should be) friends. (1978) (0)
Gating of sodium channels in cardiac Purkinje cells (1990) (0)
Electrical aspects of excitation-contraction coupling. (1976) (0)
The state of cardiac electrophysiology--1983. (1984) (0)
Adrenergic modulation of the outward current in isolated canine Purkinje cells (1990) (0)
Molecular Model of Anticonvulsant and Antidepressant Drug Binding to the Sodium Channel (2009) (0)
Reviews of Books (1987) (0)
The First Crystal Structure of a Voltage-Gated Na+ Channel Predicts a New Determinant of External Access for Hydrophilic Local Anaesthetics (2013) (0)
Basic principles of electrophysiology: Summary (1985) (0)
Morton Arnsdorf 1940–2010 (2010) (0)
Microsoft Word-28740902-file00 (2010) (0)
Novel targets for arrhythmia prevention or treatment (2005) (0)
Have we solved the arrhythmia problem? (1976) (0)
Guidelines for investigation of allegations of dishonesty in research. (1987) (0)
II The morality of scientists (1987) (0)
Myocardial injury in burn shock (1962) (0)
Cardiac voltage-gated Na channels are more sensitive to protons than skeletal channels (2003) (0)
Modal Behavior of the ,ul Na+ Channel and Effects of Coexpression of the ,13-Subunit (2005) (0)
Ion channels and transporters and cardiac arrhythmias (2000) (0)
Gating of the cardiac Na+ channel and drug interactions (1992) (0)
Morphologie substrates of sudden death: Questions and answers (1985) (0)
THE ELECTROPHYSIOLOG Y OF ACUTE MYOCARDIAL ISCHEMIA (1985) (0)
Task force VIII: Training in cardiovascular research (1986) (0)
Cardiac Sodium Channel Kinetics (1991) (0)
The ECG and the single channel. (1992) (0)

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What Schools Are Affiliated With H. A. Len Fozzard?

H. A. Len Fozzard is affiliated with the following schools:

University of Calgary
Medical University of Vienna
Virginia Commonwealth University
University of Chicago