H. Edwin Umbarger
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(Suggest an Edit or Addition)H. Edwin Umbarger's Published Works
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Published Works
- Amino acid biosynthesis and its regulation. (1978) (737)
- Evidence for a negative-feedback mechanism in the biosynthesis of isoleucine. (1956) (380)
- Regulation of amino acid metabolism. (1969) (183)
- Control of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression. (1962) (175)
- Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12. (1962) (147)
- THREONINE DEAMINATION IN ESCHERICHIA COLI II (1957) (144)
- Isoleucine and valine metabolism in Escherichia coli. VIII. The formation of acetolactate. (1958) (117)
- Isoleucine and Valine Metabolism of Escherichia coli XV. Biochemical Properties of Mutants Resistant to Thiaisoleucine (1968) (101)
- The requirement for flavine adenine dinucleotide in the formation of acetolactate by Salmonellatyphimurium extracts (1964) (99)
- Isoleucine and valine metabolism in Escherichia coli. VII. A negative feedback mechanism controlling isoleucine biosynthesis. (1958) (98)
- Expression of the Leucine Operon (1966) (91)
- BIOSYNTHESIS OF SERINE IN ESCHERICHIA COLI AND SALMONELLA TYPHIMURIUM (1963) (88)
- ISOLEUCINE AND VALINE METABOLISM IN ESCHERICHIA COLI V (1955) (85)
- CONTROL OF ISOLEUCINE, VALINE AND LEUCINE BIOSYNTHESIS. II. ENDPRODUCT INHIBITION BY VALINE OF ACETOHYDROXY ACID SYNTHETASE IN SALMONELLA TYPHIMURIUM. (1964) (84)
- Regulation of Branched-Chain Amino Acid Biosynthesis in Salmonella typhimurium: Isolation of Regulatory Mutants (1969) (83)
- α-Isopropylmalate Synthase from Salmonella typhimurium PURIFICATION AND PROPERTIES (1969) (78)
- Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. (1974) (77)
- Evidence for two distinct enzyme systems forming acetolactate in Aerobacter aerogenes. (1959) (72)
- Acetohydroxy acid synthase I of Escherichia coli: purification and properties (1979) (71)
- Nucleotide sequence of ilvGEDA operon attenuator region of Escherichia coli. (1980) (66)
- CONVERSION OF AMMONIA TO AMINO GROUPS IN ESCHERICHIA COLI (1960) (65)
- Isoleucine and valine metabolism in Escherichia coli. X. The enzymatic formation of acetohydroxybutyrate. (1961) (65)
- Metabolite analogs as genetic and biochemical probes. (1971) (64)
- Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium. (1969) (63)
- Biosynthesis of Branched-Chain Amino Acids in Yeast: Regulation of Leucine Biosynthesis in Prototrophic and Leucine Auxotrophic Strains (1968) (61)
- Isoleucine and Valine Metabolism of Escherichia coli XVI. Pattern of Multivalent Repression in Strain K-12 (1968) (60)
- Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase. (1972) (59)
- THE BIOSYNTHESIS OF LEUCINE. III. THE CONVERSION OF ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE TO ALPHA-KETOISOCAPROATE. (1963) (57)
- The Effects of Analogues of Threonine and of Isoleucine on the Properties of Threonine Deaminase (1963) (57)
- THE BIOSYNTHESIS OF LEUCINE. II. THE ENZYMIC ISOMERIZATION OF BETA-CARBOXY-BETA-HYDROXYISOCAPROATE AND ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE. (1963) (56)
- The metabolism of valine and isoleucine in Escherichia coli. XVII. The role of induction in the derepression of acetohydroxy acid isomeroreductase. (1969) (54)
- The biosynthetic pathway of serine in salmonella typhimurium. (1962) (51)
- The biosynthesis of leucine. I. The accumulation of beta-carboxy-beta-hydroxyisocaproate by leucine auxotrophs of Salmonella typhimurium and Neurospora crassa. (1963) (51)
- Isoleucine and Valine Metabolism of Escherichia coli XIV. Effect of Thiaisoleucine (1968) (49)
- Regulation of the Biosynthesis of the Branched-Chain Amino Acids (1969) (49)
- Intracellular Regulatory Mechanisms (1964) (49)
- Role of threonine deaminase in the regulation of isoleucine and valine biosynthesis. (1973) (47)
- THREONINE DEAMINATION IN ESCHERICHIA COLI I (1956) (47)
- Regulation of Transaminase C Synthesis in Escherichia coli: Conditional Leucine Auxotrophy (1974) (46)
- Utilization of L-glutamic and 2-oxoglutaric acid as sole sources of carbon by Escherichia coli. (1961) (46)
- Biosynthesis of Branched-Chain Amino Acids in Yeast: Regulation of Synthesis of the Enzymes of Isoleucine and Valine Biosynthesis (1969) (45)
- Threonine deaminase from Bacillus subtilis. II. The steady state kinetic properties. (1970) (41)
- Biosynthesis of Branched-Chain Amino Acids in Yeast: Correlation of Biochemical Blocks and Genetic Lesions in Leucine Auxotrophs (1968) (41)
- THE SEPARATION AND IDENTIFICATION OF KETOACIDS BY FILTER PAPER CHROMATOGRAPHY (1950) (39)
- Regulation of isoleucine-valine biosynthesis in an ilvDAC deletion strain of Escherichia coli K-12. (1974) (38)
- Positive control of ilvC expression in Escherichia coli K-12; identification and mapping of regulatory gene ilvY (1979) (38)
- Isoleucine and Valine Metabolism in Escherichia coli XXII. A Pleiotropic Mutation Affecting Induction of Isomeroreductase Activity (1973) (37)
- Isoleucine and Valine Metabolism in Escherichia coli XXI. Mutations Affecting Derepression and Valine Resistance (1973) (37)
- Isoleucine and valine metabolism in Escherichia coli. IX. Utilization of acetolactate and acetohydroxybutyrate. (1960) (36)
- Biosynthesis of branched-chain amino acids in yeast: effect of carbon source on leucine biosynthetic enzymes (1975) (34)
- Separate regulation of transport and biosynthesis of leucine, isoleucine, and valine in bacteria (1975) (32)
- Isoleucine and valine metabolism of Escherichia coli. I. Growth studies on amino acid-deficient mutants. (1951) (32)
- Threonine deaminase from Bacillus subtilis. I. Purification of the enzyme. (1970) (32)
- Operator constitutive mutations in the leucine operon of Salmonella typhimurium. (1969) (32)
- Threonine deamination in Escherichia coli. I. D- and L-threonine deaminase activities of cell-free extracts. (1956) (32)
- Escherichia coli and Salmonella typhimurium. Cellular and molecular biology. Volumes I and II. (1987) (30)
- Effect of Isoleucine, Valine, or Leucine Starvation on the Potential for Formation of the Branched-Chain Amino Acid Biosynthetic Enzymes (1973) (30)
- ACETOLACTATE, AN EARLY INTERMEDIATE IN VALINE BIOSYNTHESIS1 (1957) (29)
- Biosynthesis of the Branched-Chain Amino Acids in Yeast: a Leucine-Binding Component and Regulation of Leucine Uptake (1970) (29)
- Physical organization of the ilvEDAC genes of Escherichia coli strain K-12. (1978) (28)
- Isoleucine and Valine Metabolism in Escherichia coli XIX. Inhibition of Isoleucine Biosynthesis by Glycyl-Leucine (1972) (28)
- Regulation of biosynthetic pathways. (1962) (27)
- The Integration of Metabolic Pathways (1963) (26)
- Isoleucine and Valine Metabolism in Escherichia coli. III. A Method for the Quantitative Determination of α-Keto Acid Analogs of Isoleucine and Valine1 (1952) (25)
- Biosynthesis of the Branched-Chain Amino Acids in Yeast: a Trifluoroleucine-Resistant Mutant with Altered Regulation of Leucine Uptake (1970) (25)
- Biosynthesis of the Branched-Chain Amino Acids (1998) (25)
- Isoleucine and Valine Metabolism in Escherichia coli XVIII. Induction of Acetohydroxy Acid Isomeroreductase (1972) (25)
- The Regulation of Enzyme Levels in the Pathways to the Branched-Chain Amino Acids (1971) (23)
- Isoleucine and valine metabolism in Escherichia coli XIII. The role of repression in the sensitivity of strain K-12 to valine (1965) (23)
- Comparison of the regulatory regions of ilvGEDA operons from several enteric organisms (1985) (23)
- Effects of deletion and insertion mutations in the ilvM gene of Escherichia coli (1987) (22)
- Regulation of ilvEDA expression occurs upstream of ilvG in Escherichia coli: additional evidence for an ilvGEDA operon (1980) (21)
- Role of codon choice in the leader region of the ilvGMEDA operon of Serratia marcescens (1987) (21)
- Threonine deaminases. (1973) (20)
- THE ABSOLUTE CONFIGURATION OF ALPHA-HYDROXY-BETA-CARBOXYISOCAPROIC ACID (3-ISOPROPYLMALIC ACID), AN INTERMEDIATE IN LEUCINE BIOSYNTHESIS. (1964) (20)
- Purification of yeast alpha-isopropylmalate isomerase. High ionic strength hydrophobic chromatography. (1975) (20)
- Location of the multivalent control site for the ilvEDA operon of Escherichia coli (1980) (20)
- Isoleucine and Valine Metabolism in Escherichia coli K-12: Detection and Measurement of ilv-Specific Messenger Ribonucleic Acid (1974) (19)
- Physical location of the ilvO determinant in Escherichia coli K-12 deoxyribonucleic acid (1980) (19)
- A role for a pyridoxne derivative in the multivalent repression of the isoleucine and valine biosynthetic enzymes. (1973) (18)
- Leucine regulation of the ilvGEDA operon of Serratia marcescens by attenuation is modulated by a single leucine codon (1985) (18)
- Physical characterization of ilv-lac fusions (1979) (18)
- Regulation of Synthesis of the Branched-Chain Amino Acids and Cognate Aminoacyl-Transfer Ribonucleic Acid Synthetases of Escherichia coli: a Common Regulatory Element (1974) (18)
- Characterization of fusions between the lac operon and the ilv gene cluster in Escherichia coli: ilvC-lac fusions (1977) (17)
- Yeast alpha-isopropylmalate isomerase. Factors affecting stability and enzyme activity. (1976) (17)
- Feedback control by endproduct inhibition. (1961) (16)
- Translational coupling between the ilvD and ilvA genes of Escherichia coli (1988) (16)
- Isoleucine and valine metabolism of Escherichia coli. II. The accumulation of keto acids. (1951) (16)
- Specificity of attenuation control in the ilvGMEDA operon of Escherichia coli K-12 (1991) (15)
- Polarity and the regulation of the ilv gene cluster in Escherichia coli strain K-12 (1976) (15)
- Isoleucine and valine metabolism in Escherichia coli. V. alpha-Ketoisovaleric acid accumulation. (1953) (14)
- In vitro synthesis of beta-galactosidase with ilv-lac fusion deoxyribonucleic acid as template (1977) (14)
- Alpha-isopropylmalate synthase from Salmonella typhimurium. Purification and properties. (1969) (14)
- THE INFLUENCE OF THE ENVIRONMENT ON ACETATE METABOLISM IN ESCHERICHIA COLI (1954) (14)
- [212] l-Threonine deaminase, biosynthetic (Bacillus subtilis) (1971) (14)
- Role for Free Isoleucine or Glycyl-Leucine in the Repression of Threonine Deaminase in Escherichia coli (1974) (14)
- ilvU, a locus in Escherichia coli affecting the derepression of isoleucyl-tRNA synthetase and the RPC-5 chromatographic profiles of tRNAIle and tRNAVal. (1979) (14)
- The origin of a useful concept – Feedback inhibition (1992) (13)
- THE EFFECT OF L-VALINE ON ENZYME SYNTHESIS IN ESCHERICHIA COLI K-12. (1965) (12)
- CONTROL OF ISOLEUCINE , VALINE , AND LEUCINE BIOSYNTHESIS (2003) (12)
- A time-dependent activation of threonine deaminase. (1968) (11)
- Isoleucine and Valine Metabolism in Escherichia coli. IV. Competitive Interactions in the Transamination Reactions of Isoleucine and Valine1 (1952) (11)
- Defective Transamination, a Mechanism for Resistance to Ketomycin in Escherichia coli (1973) (11)
- Isolation and analysis of two Escherichia coli K-12 ilv attenuator deletion mutants with high-level constitutive expression of an ilv-lac fusion operon (1984) (11)
- Exogenous Valine Reduces Conversion of Leucine to 3-Methyl-1-Butanol in Saccharomyces cerevisiae (1983) (9)
- COLORIMETRIC METHOD FOR THE ESTIMATION OF GROWTH IN CUP ASSAYS (1960) (8)
- ISOLEUCINE AND VALINE METABOLISM IN ESCHERICHIA COLI XI. K-12 (1962) (8)
- Mutations affecting the formation of acetohydroxy acid synthase II in Escherichia coli K-12 (1979) (8)
- Participation of Branched-Chain Amino Acid Analogues in Multivalent Repression (1973) (8)
- Physical and genetic localization of ilv regulatory sites in lambda ilv bacteriophages (1982) (8)
- Mutations replacing the leucine codons or altering the length of the amino acid-coding portion of the ilvGMEDA leader region of Escherichia coli (1991) (7)
- Mutations in the ilvY gene of Escherichia coli K-12 that cause constitutive expression of ilvC (1981) (7)
- Effect of a leu-linked mutation on the valine sensitivity of acetohydroxy acid synthase activity in Escherichia coli (1975) (6)
- A one-semester project for the immersion of graduate students in metabolic pathways☆ (1977) (6)
- Advances in Enzyme Regulation.G. Weber (1967) (6)
- THE NUTRITIONAL REQUIREMENTS OF THREONINELESS MUTANTS OF ESCHERICHIA COLI (1953) (5)
- INFLUENCE OF GLUCOSE ON THE GROWTH FACTOR REQUIREMENT OF A MUTANT OF ESCHERICHIA COLI (1953) (5)
- Comments on the Role of Aminoacyl-tRNA in the Regulation of Amino Acid Biosynthesis (1980) (5)
- Specificity of the stimulation of in vitro ribonucleic acid synthesis by guanosine 5′-diphosphate 3′-diphosphate (1975) (4)
- The absence of branched-chain amino acid and growth rate control at the internal ilvEp promoter of the ilvGMEDA operon (1991) (4)
- SINGLE REACTIONS WITH MULTIPLE FUNCTIONS: MULTIPLE ENZYMES AS ONE OF THREE PATTERNS IN MICROORGANISMS (1975) (4)
- Exogenous Valine Reduces Conversion of Leucine to 3-Methyl-1-Butanol in Saccharomyces cerevisiae (1983) (4)
- [105] Isopropylmalate isomerase (yeast) (1970) (3)
- Deoxyribonucleic Acid-Directed In Vitro Synthesis of ilv-Specific Messenger Ribonucleic Acid by Extracts of Escherichia coli K-12 (1974) (3)
- Threonine deaminase from Bacillus subtilis. 3. Pre-steady state kinetic properties. (1970) (3)
- Evidence for a Negative-Feedback Mechanism in the Biosynthesis of Isoleucine (1956) (3)
- On the role of isoleucyl-tRNA synthetase in multivalent repression (1972) (2)
- In vitro formation of beta-galactosidase with a template containing the lac genes fused to gene ilvD (1980) (2)
- On the Role of Isoleueyl-tRNA Synthetase in Multi- valent Repression (1972) (1)
- ON THE MECHANISM OF DEVELOPMENT OF RESISTANCE TO STREPTOMYCIN IN MICROCOCCUS PYOGENES VAR. AUREUS (1955) (1)
- Diauxie Used as a Microbiological Assay for L-Isoleucine or L-Valine in Escherichia coli (1)
- Erratum (2021) (0)
- Pleiotropic effects of an ilv y mutation on threonine deaminase in escherichia coli (1972) (0)
- Letter from H. Edwin Umbarger to Joshua Lederberg (1954) (0)
- Effect ofIsoleucine, Valine, orLeucine Starvation onthePotential forFormation ofthe Branched-Chain AminoAcidBiosynthetic Enzymes (1973) (0)
- Effects ofDeletion andInsertion Mutations intheilvMGeneof Escherichia coli (1987) (0)
- XXI. Mutations Affecting Derepression and Valine Resistance (0)
- Physical andGenetic Localization ofilvRegulatory Sites inX ilvBacteriophages (1982) (0)
- Physical organization of the JlvEDAC genes of Escherichia coli strain K-12 ( isoleucine and valine biosynthesis / restriction endonuclease mapping / heteroduplex analysis / gene expression ) (0)
- TheAbsence ofBranched-Chain AminoAcidandGrowthRate Control attheInternal ilvEp Promoter oftheilvGMEDAOperont (1991) (0)
- The rôle of alpha-keto- beta-ethylbutyric acid in the biosynthesis of isoleucine. (1951) (0)
- Microbial Regulatory Mechanisms: Obstacles and Tools for the Biochemical Engineer (1983) (0)
- American Society of Microbiology (1987) (0)
- Molecular mechanisms underlying the multivalent regulation of 5 transcriptional units of the ilv regulon in escherichia coli (1983) (0)
- RESTRICTION ANALYSIS AND CLONING OF DNA FROM THE ILV GENE CLUSTER OF E. COLI K12 (1977) (0)
- THIE NUTRITIONAL REQUIREMENTS OF THREONINELESS MUTANTS OF ESCHERICHIA COLI ' (0)
- Regulation mechanisms in the biosynthesis of alpha-acetolactic acid by Aerobacter aerogenes. (1959) (0)
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