H. Peter Metzger

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H. Peter Metzger is affiliated with the following schools: University of New Mexico, Johns Hopkins University

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H. Peter Metzger

Biology

#6545

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#9284

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Cell Biology

#217

World Rank

#225

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Genetics

#608

World Rank

#691

Historical Rank

Molecular Biology

#684

World Rank

#701

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Biology

H. Peter Metzger's Degrees

PhD Molecular Biology Stanford University

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H. Peter Metzger's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Complete structure and expression in transfected cells of high affinity IgE receptor (1989) (494)
The receptor with high affinity for immunoglobulin E. (1986) (489)
The influence of polyvalency on the binding properties of antibodies. (1972) (378)
Signal transduction by Fc receptors: the Fc&RI case (1993) (352)
Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. (1977) (334)
Structural basis of antibody function. (1983) (329)
Affinity labeling of a phosphorylcholine binding mouse myeloma protein. (1972) (328)
THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS (1974) (254)
Transmembrane signaling: the joy of aggregation. (1992) (253)
The Receptor with High Affinity for IgE (1992) (231)
CHARACTERIZATION OF A HUMAN MACROGLOBULIN. I. THE MOLECULAR WEIGHT OF ITS SUBUNIT. (1965) (228)
Assessment of Compositional Relatedness between Proteins (1968) (223)
THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS (1974) (208)
Interaction between proteins localized in membranes. (1986) (205)
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. (1994) (196)
Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase. (1994) (183)
Expression of high-affinity binding of human immunoglobulin E by transfected cells. (1989) (180)
Affinity labeling-a general method for labeling the active sites of antibody and enzyme molecules. (1962) (179)
Structure and function of gamma M macroglobulins. (1970) (173)
Investigation of Early Events in FcεRI-Mediated Signaling Using a Detailed Mathematical Model1 (2003) (170)
An unusual mechanism for ligand antagonism. (1998) (163)
Structure-function relationships in the mast cell high affinity receptor for IgE. Role of the cytoplasmic domains and of the beta subunit. (1991) (162)
Effect of antigen binding on the properties of antibody. (1974) (162)
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide. (1970) (156)
Fc receptors and the action of antibodies (1990) (141)
Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells. (1980) (139)
The effect of antigen on antibodies: recent studies. (1978) (136)
Lateral motion and valence of Fc receptors on rat peritoneal mast cells (1976) (122)
The Unique Domain as the Site on Lyn Kinase for Its Constitutive Association with the High Affinity Receptor for IgE* (1997) (122)
Characterization of Gene Expression in Resting and Activated Mast Cells (1998) (120)
Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water. (1986) (118)
Characterization of a human macroglobulin. II. Distribution of the disulfide bonds. (1965) (116)
Signal transduction by Fc receptors: the Fc epsilon RI case. (1993) (107)
Structural and functional properties of the „hairy”︁ cells of leukemic reticuloendotheliosis (1978) (106)
ELECTRON MICROSCOPIC LOCALIZATION OF IMMUNOGLOBULIN E ON THE SURFACE MEMBRANE OF HUMAN BASOPHILS (1971) (104)
Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. (1988) (103)
SURFACE IgE ON HUMAN BASOPHILS DURING HISTAMINE RELEASE (1973) (103)
A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. (1987) (94)
Studies with a monoclonal antibody to the beta subunit of the receptor with high affinity for immunoglobulin E. (1988) (93)
A Waldenström macroglobulin which binds nitrophenyl ligands. (1969) (92)
The high affinity receptor for IgE on mast cells (1991) (88)
Triggering of cultured neoplastic mast cells by antibodies to the receptor for IgE. (1978) (84)
Characterization of a human macroglobulin. 3. The products of tryptic digestion. (1966) (81)
Further characterization of the β-component of the receptor for immunoglobulin E (1982) (80)
The IgE‐Mast Cell System as a Paradigm for the Study of Antibody Mechanisms (1978) (77)
Characterization of a human macroglobulin. V. A Waldenström macroglobulin with antibody activity. (1967) (76)
Association of the receptor for immunoglobulin E with an endogenous polypeptide on rat basophilic leukemia cells. (1980) (71)
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Sequence and position of a labeled tryptic peptide. (1970) (70)
A previously unrecognized subunit of the receptor for immunoglobulin E. (1983) (69)
EditorialMyeloma proteins and antibodies (1969) (68)
Reconstitution of the receptor for immunoglobulin E into liposomes. Conditions for incorporation of the receptor into vesicles. (1982) (67)
Binding properties of a Waldenström macroglobulin antibody. (1968) (63)
Distribution and valency of receptor for IgE on rodent mast cells and related tumour cells (1976) (59)
Functional comparison of Fc epsilon RI, Fc gamma RII, and Fc gamma RIII in mast cells. (1992) (57)
Proteolysis of soluble IgE-receptor complexes: localization of sites on IgE which interact with the Fc receptor. (1982) (56)
Composition and subunit structure of the cell receptor for immunoglobulin E. (1980) (56)
Noncytotoxic IgE-mediated release of histamine and serotonin from murine mastocytoma cells. (1977) (56)
Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response. (1997) (55)
The antigen receptor problem. (1970) (54)
Phase separation of the receptor for immunoglobulin E and its subunits in Triton X-114. (1984) (52)
Preparative isolation of the cell receptor for immunoglobulin E. (1979) (52)
Isolation of IgE from reaginic rat serum. (1974) (52)
Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells. (1983) (52)
Cell cycle-associated changes in receptors for IgE during growth and differentiation of a rat basophilic leukemia cell line (1975) (52)
Translocation of protein kinase C in rat basophilic leukemic cells induced by phorbol ester or by aggregation of IgE receptors. (1988) (52)
Phospholipids stabilize the interaction between the alpha and beta subunits of the solubilized receptor for immunoglobulin E. (1982) (52)
AFFINITY LABELING OF THE ACTIVE SITES OF ANTIBODIES TO THE 2,4-DINITROPHENYL HAPTEN. (1963) (51)
Unexpected signals in a system subject to kinetic proofreading (2001) (51)
Surface expression of mutated subunits of the high affinity mast cell receptor for IgE. (1990) (50)
Dissociation of the receptor for immunoglobulin E in mild detergents. (1985) (49)
The chemistry of the immunoglobulins. (1967) (49)
Exploiting the difference between intrinsic and extrinsic kinases: implications for regulation of signaling by immunoreceptors. (1997) (48)
Initial characterization of the calcium channel activated by the cross-linking of the receptors for immunoglobulin E. (1984) (48)
Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE. (1994) (47)
Binding Capacity of Reductively Fragmented Antibodies to the 2,4-Dinitrophenyl Group (1963) (46)
Immobilization and internalization of mutated IgE receptors in transfected cells. (1991) (46)
How antibodies work: focus on Fc receptors (1988) (45)
The receptor with high affinity for IgE. (1992) (45)
A SPECIFIC ANTIBODY-HAPTEN REACTION WITH NOVEL SPECTRAL PROPERTIES. (1963) (45)
RECOMBINATION OF ANTIBODY POLYPEPTIDE CHAINS IN THE PRESENCE OF ANTIGEN (1964) (45)
Characterization of Protein-tyrosine Phosphatases That Dephosphorylate the High Affinity IgE Receptor* (1997) (45)
Ionophore A-23187 induced histamine release from rat mast cells and rat basophil leukemia (RBL-1) cells. (1975) (44)
Coordinate synthesis and degradation of the α-, β- and γ-subunits of the receptor for immunoglobulin E (1985) (42)
Qualitative characteristics of histamine release from human basophils by covalently cross-linked IgE. (1981) (42)
Assay and partial characterization of the solubilized cell surface receptor for immunoglobulin E. (1977) (40)
Interaction between the Unphosphorylated Receptor with High Affinity for IgE and Lyn Kinase* (2001) (40)
Cytophilic binding of IgE to the macrophage. III. Involvement of cyclic GMP and calcium in macrophage activation by dimeric or aggregated rat myeloma IgE. (1980) (39)
THE PARTICIPATION OF A AND B POLYPEPTIDE CHAINS IN THE ACTIVE SITES OF ANTIBODY MOLECULES. (1964) (39)
The Valence of a Waldenström Macroglobulin Antibody and Further Thoughts on the Significance of Paraprotein Antibodies (1967) (38)
Molecular aspects of receptors and binding factors for IgE. (1988) (36)
Calcium-independent phosphoinositide breakdown in rat basophilic leukemia cells. Evidence for an early rise in inositol 1,4,5-trisphosphate which precedes the rise in other inositol phosphates and in cytoplasmic calcium. (1987) (36)
The receptor on mast cells and related cells with high affinity for IgE. (1983) (36)
Biochemical Evidence That the Phosphorylated Tyrosines, Serines, and Threonines on the Aggregated High Affinity Receptor for IgE Are in the Immunoreceptor Tyrosine-based Activation Motifs* (1997) (35)
One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors. (1999) (35)
Investigation of early events in Fc epsilon RI-mediated signaling using a detailed mathematical model. (2003) (35)
Binding of immunoglobulin E to the receptor on rat peritoneal macrophages. (1982) (35)
Kinetics of Tyrosine Phosphorylation When IgE Dimers Bind to FCε Receptors on Rat Basophilic Leukemia Cells (*) (1995) (34)
Disparity of IgE binding between normal and tumor mouse mast cells. (1976) (34)
The receptor for immunoglobulin E: examination for kinase activity and as a substrate for kinases. (1986) (34)
The properties of thyroglobulin. VII. The immunoloic activity of thyroglobulin fragments. (1962) (33)
Reaction of 5-iodonaphthyl-1-nitrene with the IgE receptor on normal and tumour mast cells (1981) (33)
Noncovalently and covalently bound lipid on the receptor for immunoglobulin E. (1985) (33)
Phosphorylation of the receptor of immunoglobulin E. (1982) (33)
Molecular weight and valence of the cell-surface receptor for immunoglobulin E. (1977) (33)
Effects of subunit mutation on the localization to coated pits and internalization of cross-linked IgE-receptor complexes. (1993) (32)
Secretion from rat basophilic leukaemia cells induced by calcium ionophores. Effect of pH and metabolic inhibition. (1981) (31)
Transmembrane signaling by the high-affinity IgE receptor on membrane preparations. (1992) (30)
Detergent-resistant Microdomains Offer No Refuge for Proteins Phosphorylated by the IgE Receptor* (2000) (30)
Interaction of aggregated native and mutant IgE receptors with the cellular skeleton. (1992) (29)
Some physical chemical aspects of receptor-ligand interactions. (1976) (29)
Reconstitution of the receptor for immunoglobulin E into liposomes. Reincorporation of purified receptors. (1984) (28)
Affinity Site Labeling of a Mouse Myeloma Protein Which Binds Dinitrophenyl Ligands (1968) (28)
Enzymatic cleavage products of the alpha subunit of the receptor for immunoglobulin E. (1981) (28)
Structure of the high-affinity mast cell receptor for IgE. (1982) (28)
A search for conformational change on ligand binding in a human M macroglobulin. I. Circular dichroism and hydrogen exchange. (1971) (28)
Characterization of a human macroglobulin. IV. Studies of its conformation by fluorescence polarization. (1966) (26)
The Properties of Thyroglobulin. V. The Properties of Denatured Thyroglobulin (1961) (26)
Evolution of Immunoglobulin Polypeptide Chains: Carboxy-Terminal of an IgM Heavy Chain (1966) (26)
It’s Spring, and Thoughts Turn to … Allergies (1999) (26)
Analysis of the structure and function of the receptor for immunoglobulin E. (1984) (26)
Changes in the receptor for immunoglobulin E coincident with receptor-mediated stimulation of basophilic leukemia cells. (1983) (26)
Unexpected findings from target analysis of immunoglobulin E and its receptor. (1981) (25)
Interaction of IgE with rat basophilic leukemia cells. IV. Antibody-induced redistribution of IgE receptors. (1974) (24)
The Specificity of a Monoclonal Macroglobulin (γM) Antibody: Reactivity with Primate γG Immunoglobulins (1969) (23)
The separation of rabbit anti-dinitrophenyl IgG antibodies on the basis of combining site depth. (1974) (23)
A search for conformational change on ligand binding in a human M macroglobulin. II. Susceptibility to proteolysis. (1971) (23)
Transmembrane signaling in P815 mastocytoma cells by transfected IgE receptors. (1990) (23)
Interaction of IgE with rat basophilic leukemia cells--V. Binding properties of cell free particles. (1976) (22)
Study of macromolecular interactions by equilibrium molecular sieving. (1968) (22)
Simple radio-immunoassay for the measurement of human and rat IgE levels by ammonium sulfate precipitation. (1975) (22)
Modification of Immunoglobulin Combining Sites (1971) (22)
Analysis of the rate-limiting step in a ligand-cell receptor interaction: the IgE system (1983) (21)
The interaction of IgE with rat basophilic leukemia cells--VI. Inhibition by IgGa immune complexes. (1976) (20)
Summary of workshop on homogeneous immunoglobulins with binding activity (1969) (20)
IgE receptor-mediated hydrolysis of phosphoinositides by cytoplasts from rat basophilic leukemia cells. (1989) (20)
Serum IgE levels during the potentiated reagin response to egg albumin in rats infected with Nippostrongylus brasiliensis. (1975) (18)
Amino terminal sequences of human immunoglobulin heavy chains. (1971) (18)
Synthesis and Secretion of Monocyte Chemotactic Protein-1 Stimulated by the High Affinity Receptor for IgE (2003) (17)
Only the smile is left (1988) (17)
Quantitative aspects of signal transduction by the receptor with high affinity for IgE. (2002) (15)
Isolation of cross-linked IgE-receptor complexes from rat macrophages. (1983) (14)
Molecular versatility of antibodies (2002) (14)
The Properties of Thyroglobulin. IV. Denaturation Kinetics (1961) (14)
Spontaneous phosphorylation of the receptor with high affinity for IgE in transfected fibroblasts. (2001) (14)
Chemical cross-linking of IgE-receptor complexes in RBL-2H3 cells. (1995) (14)
Evidence that the "mouse mastocytoma" cell line (MCT-1) is of rat origin. (1978) (14)
Partial sequences of six macroglobulin light chains. Absence of sequence correlates to functional activity. (1969) (13)
Analysis of the rate-limiting step in a ligand-cell receptor interaction: the immunoglobulin E system. (1983) (13)
Coordinate synthesis and degradation of the alpha-, beta- and gamma-subunits of the receptor for immunoglobulin E. (1985) (13)
Mediation of effector functions by antibodies: report of a workshop. (1979) (13)
Further characterization of the subunits of the receptor with high affinity for immunoglobulin E. (1987) (12)
The Atomic Establishment (1972) (12)
Stimulus-secretion coupling in rat basophilic leukemia cells. (1981) (12)
Gel filtration in 6 M guanidine hydrochloride of the alpha-subunit (and its fragments) of the receptor for immunoglobulin E. (1982) (12)
Covalent cross-linking of subunits of the receptor for immunoglobulin E induced by immunoprecipitation. (1983) (12)
Emerging picture of the receptor with high affinity for IgE. (1989) (12)
The influence of actin microfilaments on signaling by the receptor with high-affinity for IgE. (2004) (11)
Fc epsilon RI-mediated hydrolysis of phosphoinositides in ghosts derived from rat basophilic leukemia cells. (1991) (11)
The high affinity receptor for IgE, FcepsilonRI. (2004) (11)
Interaction of IgE with rat basophilic leukemia cells. III. Release of intact receptors on cell-free particles. (1975) (11)
Fc receptors and membrane immunoglobulin. (1991) (11)
Characterization of the receptors for IgE on membranes isolated from rats basophilic leukemia cells. (1982) (11)
Transmembrane signaling by receptor aggregation: The mast cell receptor for IgE as a case study. Introduction (1982) (10)
Early molecular events in antigen-antibody cell activation. (1979) (9)
Hybrid Antibody Molecules with Allotypically Different L-Polypeptide Chains (1965) (9)
Human IgA-myeloma protein which binds nitrophenyl ligands. (1970) (8)
The binding of antibodies to the solubilized and membrane-integrated mouse and rat receptor for IgE. (1977) (8)
A quantitative approach to signal transduction. (1999) (8)
Nitration of a nitrophenyl-binding M macroglobulin. (1971) (7)
Antibodies as effector molecules. (1984) (7)
USE OF HOMOGENEOUS IMMUNOGLOBULINS FOR STUDYING THE EFFECTS OF ANTIBODY POLYVALENCE (1971) (6)
Purification of Anti-Thyroglobin Antibodies (1962) (6)
Signal transduction by FcεRI: Analysis of the early molecular events (1999) (5)
Further characterization of the beta-component of the receptor for immunoglobulin E. (1982) (5)
Eureka! And other pleasures. (1998) (5)
The High Anity Receptor for IgE, FcϵRI (2008) (5)
The role of aggregation in the function of the IgE Fc receptors. (1980) (5)
The high-affinity receptor for immunoglobulin E. Prospects for the therapy of immediate hypersensitivity reactions. (1988) (5)
Quantitative aspects of receptor aggregation. (1994) (5)
Two approaches to peanut allergy. (2003) (4)
Immunoglobulin Receptors: Handicapping the immune response (1994) (4)
Aggregation of the high-affinity IgE receptor and enhanced activity of p 53 / 56 lYn protein-tyrosine kinase ( transmembrane signaling / mast cells / chemical crosslinking / permeabilization / rat basophilic leukemia cells ) (4)
G-protein coupled receptors, nitric oxide, and the IgE receptor in asthma. (1995) (4)
Use of the airfuge for analysis and preparation of receptors incorporated into liposomes: studies with the receptor for immunoglobulin E. (1983) (4)
The High Affinity Receptor for Immunoglobulin E: New Developments (1989) (3)
Myeloma proteins and antibodies. (1965) (3)
The receptor for immunoglobulin E: taking it apart - putting it back together. Carl Prausnitz Memorial Lecture. (1983) (3)
Kinetics of tyrosine phosphorylation when IgE dimers bind to FC epsilon receptors on rat basophilic leukemia cells. (1995) (3)
Effects of subunit mutation on the rotational dynamics of Fc epsilon RI, the high affinity receptor for IgE, in transfected cells. (1995) (3)
The receptor for immunoglobulin E as a membrane protein. (1986) (2)
Protein Dimerization: Inside job (1994) (2)
ANTIBODY STRUCTURE AND THE IMMUNE RESPONSE (1974) (2)
The mechanism of action of antibodies. (1984) (1)
Structure and Function of the Receptor for Immunoglobulin E (IgE) on Mast Cells (1981) (1)
527 IgE receptor-mediated hydrolysis of phosphoinositides (PI) by lysed cytoplasts from rat basophilic leukemia (RBL) cells (1988) (0)
Ionophore induced histamine release from rat mast cells and rat basophilic leukemia (RBL 1) cells (1975) (0)
Feeder door mechanism (2008) (0)
IUIS council meets. (1984) (0)
Structural basis for the interaction of lyn kinase with the unphosphorylated high affinity receptor for IgE Fc(RI) (1998) (0)
For the gamma subunit of the high affinity receptor encoding immunoglobulin e cDNAs (1989) (0)
Vaccines and infectious disease. (1982) (0)
The Role of IgE and Its Receptor in Mediating Secretion (1983) (0)
Structural analyses of the receptor for IgE on rat basophilic leukemia cells. (1981) (0)
Immunochemical methods in the biological sciences: Enzymes and proteins: By R. J. Mayer and J. H. Walker, Academic Press, New York, 1980. 168 pp. $29.50 (1981) (0)
High Affinity Receptor for IgE Chemotactic Protein-1 Stimulated by the Synthesis and Secretion of Monocyte (2003) (0)
STUDIES ON THE CELL SURFACE RECEPTORS FOR IgE (1975) (0)
I. Evidence for Specific Binding 0]~ Ige (0)
Isolation of labeled peptide from affinity labeled mouse myeloma protein 315. Abstr. (1970) (0)
Book Review:Receptors: Models for Binding, Trafficking, and Signaling. Douglas A. Lauffenburger, Jennifer J. Linderman (1995) (0)
Methods in enzymology: Vol. 70, Immunochemical Techniques, Part A. Edited by H. V. Vunakis and J. J. Langone, Academic Press, New York, 1980. $48.00 (1981) (0)
Annual Review of Immunology (1984) (0)
The specificity of a monoclonal macroglobulin (gamma M) antibody: reactivity with primate gamma G immunoglobulins. (1969) (0)
Signal Transduction by the Receptor with High Affinity for IgE (1993) (0)
Signaling Using a Detailed Mathematical Model RI-Mediated ε Investigation of Early Events in Fc (2012) (0)
Nomenclature of the Fc receptors (1998) (0)
Early Signals in Mast Cell Activation: A Perspective (1999) (0)
Studies on the translocation of protein kinase C in RBL-2H3 cells stimulated by phorbol ester or antigen (1987) (0)
The Receptor for Immunoglobulin E on Mast Cells and Basophils (1984) (0)
Coordinate synthesis and catabolism of the α, β and γ components of the receptor for IgE (1985) (0)
MOLECULAR MECHANISMS OF ANTIBODY ACTION: USE OF CROSS-LINKING REAGENTS (1980) (0)

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What Schools Are Affiliated With H. Peter Metzger?

H. Peter Metzger is affiliated with the following schools:

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Why Is H. Peter Metzger Influential?

H. Peter Metzger's Published Works

Published Works

What Schools Are Affiliated With H. Peter Metzger?

H. Peter Metzger's AcademicInfluence.com Rankings