Hiroshi Nikaido

Q: What Schools Are Affiliated With Hiroshi Nikaido

Hiroshi Nikaido is affiliated with the following schools: University of California, Berkeley, University of Milan, Yamaguchi University, University of Verona, Johns Hopkins University, University of Saskatchewan, University of Helsinki

Hiroshi Nikaido's AcademicInfluence.com Rankings

Hiroshi Nikaido

Biology

#2357

World Rank

#3755

Historical Rank

Microbiology

#53

World Rank

#71

Historical Rank

Biochemistry

#196

World Rank

#248

Historical Rank

biology Degrees

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Biology

Hiroshi Nikaido's Degrees

PhD Biochemistry University of Tokyo

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Hiroshi Nikaido's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular Basis of Bacterial Outer Membrane Permeability Revisited (2003) (3427)
Molecular basis of bacterial outer membrane permeability. (1985) (2195)
The envelope of mycobacteria. (1995) (1817)
Prevention of drug access to bacterial targets: permeability barriers and active efflux. (1994) (1473)
Multidrug resistance in bacteria. (2009) (1315)
Multidrug efflux pumps of gram-negative bacteria (1996) (1067)
Efflux-Mediated Drug Resistance in Bacteria (2012) (981)
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria (2015) (909)
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants (1996) (805)
Genes acrA and acrB encode a stress‐induced efflux system of Escherichia coli (1995) (669)
Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa (1995) (647)
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria. (2012) (580)
Mycobacterial cell wall: structure and role in natural resistance to antibiotics. (1994) (555)
Active efflux of bile salts by Escherichia coli (1997) (486)
Multidrug resistance mechanisms: drug efflux across two membranes (2000) (482)
Outer membrane barrier as a mechanism of antimicrobial resistance (1989) (479)
Molecular cloning and characterization of acrA and acrE genes of Escherichia coli (1993) (475)
Mechanisms of RND multidrug efflux pumps. (2009) (464)
Efflux-Mediated Drug Resistance in Bacteria (2009) (450)
Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins (1983) (437)
Involvement of an Active Efflux System in the Natural Resistance of Pseudomonas aeruginosa to Aminoglycosides (1999) (415)
The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals (1996) (405)
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin (1994) (403)
Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump (2003) (392)
Outer membrane of Salmonella typhimurium. Transmembrane diffusion of some hydrophobic substances. (1976) (388)
Porin channels in Escherichia coli: studies with beta-lactams in intact cells (1983) (379)
Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. (1999) (375)
Antibiotic resistance caused by gram-negative multidrug efflux pumps. (1998) (373)
Porins and specific diffusion channels in bacterial outer membranes. (1994) (365)
Outer membrane of Salmonella typhimurium: chemical analysis and freeze-fracture studies with lipopolysaccharide mutants (1975) (360)
Outer membrane of Salmonella typhimurium: accessibility of phospholipid head groups to phospholipase c and cyanogen bromide activated dextran in the external medium. (1976) (346)
Protein Composition of the Outer Membrane of Salmonella typhimurium: Effect of Lipopolysaccharide Mutations (1974) (344)
The Outer Membrane of Gram-negative Bacteria (1980) (336)
Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins (1997) (331)
Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria. (2001) (324)
Porins and specific channels of bacterial outer membranes (1992) (323)
Multiple antibiotic resistance and efflux. (1998) (322)
Efflux pumps and drug resistance in gram-negative bacteria. (1994) (311)
Outer membranes of gram-negative bacteria. XIX. Isolation from Pseudomonas aeruginosa PAO1 and use in reconstitution and definition of the permeability barrier (1978) (307)
Microbial Biotechnology: Fundamentals of Applied Microbiology (1995) (305)
Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa (1990) (303)
CHAPTER 4 – Isolation and Chemical and Immunological Characterization of Bacterial Lipopolysaccharides (1971) (302)
Permeability barrier to hydrophilic solutes in Mycobacterium chelonei (1990) (297)
Substrate Specificity of the RND-Type Multidrug Efflux Pumps AcrB and AcrD of Escherichia coli Is Determined Predominately by Two Large Periplasmic Loops (2002) (295)
Outer membrane of gram-negative bacteria. XII. Molecular-sieving function of cell wall (1976) (292)
Properties of AdeABC and AdeIJK Efflux Systems of Acinetobacter baumannii Compared with Those of the AcrAB-TolC System of Escherichia coli (2014) (290)
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance (1994) (290)
Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein (2003) (289)
Mycolic Acid Structure Determines the Fluidity of the Mycobacterial Cell Wall* (1996) (281)
Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide (1999) (279)
Diffusion of beta-lactam antibiotics through the porin channels of Escherichia coli K-12 (1985) (275)
Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins. (1992) (269)
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples (1993) (267)
The BaeSR Two-Component Regulatory System Activates Transcription of the yegMNOB (mdtABCD) Transporter Gene Cluster in Escherichia coli and Increases Its Resistance to Novobiocin and Deoxycholate (2002) (265)
Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. (1998) (261)
Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides (2003) (258)
Multidrug Efflux Pump AcrAB of Salmonella typhimuriumExcretes Only Those β-Lactam Antibiotics Containing Lipophilic Side Chains (1998) (253)
Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes (1982) (251)
Efflux Pump-Mediated Intrinsic Drug Resistance in Mycobacterium smegmatis (2004) (243)
AcrD of Escherichia coli Is an Aminoglycoside Efflux Pump (2000) (238)
Pore-forming activity of OmpA protein of Escherichia coli. (1992) (235)
AcrAB and related multidrug efflux pumps of Escherichia coli. (2001) (232)
AcrA is a highly asymmetric protein capable of spanning the periplasm. (1999) (219)
Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli (1981) (216)
Protein D2 channel of the Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides. (1990) (214)
A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study (2005) (214)
Transport proteins in bacteria: common themes in their design. (1992) (206)
AcrB Multidrug Efflux Pump of Escherichia coli: Composite Substrate-Binding Cavity of Exceptional Flexibility Generates Its Extremely Wide Substrate Specificity (2003) (205)
Specificity of diffusion channels produced by lambda phage receptor protein of Escherichia coli. (1980) (198)
Aminoglycosides Are Captured from both Periplasm and Cytoplasm by the AcrD Multidrug Efflux Transporter of Escherichia coli (2005) (198)
Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations (2012) (196)
Identification and characterization of porins in Pseudomonas aeruginosa. (1991) (193)
Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis? (1995) (193)
Mutants of Escherichia coli That Are Resistant to Certain Beta-Lactam Compounds Lack the ompF Porin (1981) (192)
Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides (2014) (182)
Sensitivity of Escherichia coli to various β‐lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic β‐lactamases: a quantitative predictive treatment (1987) (181)
Outer membranes of Gram‐negative bacteria are permeable to steroid probes (1992) (180)
Physical organization of lipids in the cell wall of Mycobacterium chelonae (1993) (179)
Cross-Linked Complex between Oligomeric Periplasmic Lipoprotein AcrA and the Inner-Membrane-Associated Multidrug Efflux Pump AcrB from Escherichia coli (2000) (172)
Structure and mechanism of RND-type multidrug efflux pumps. (2011) (172)
Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli (2010) (154)
The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump (1997) (153)
Outer membrane permeability and beta-lactamase stability of dipolar ionic cephalosporins containing methoxyimino substituents (1990) (149)
Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli (1995) (148)
PhoPQ-Mediated Regulation Produces a More Robust Permeability Barrier in the Outer Membrane of Salmonella enterica Serovar Typhimurium (2007) (148)
Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli. (1991) (148)
Fluidity of the lipid domain of cell wall from Mycobacterium chelonae. (1995) (145)
Contributions of MexAB-OprM and an EmrE Homolog to Intrinsic Resistance of Pseudomonas aeruginosa to Aminoglycosides and Dyes (2003) (145)
Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. (1988) (145)
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives (2016) (142)
High-Level Fluoroquinolone-Resistant Clinical Isolates of Escherichia coli Overproduce Multidrug Efflux Protein AcrA (2000) (141)
Identification of the protein producing transmembrane diffusion pores in the outer membrane of Pseudomonas aeruginosa PA01. (1979) (140)
Outer membrane of gram-negative bacteria. XVIII. Electron microscopic studies on porin insertion sites and growth of cell surface of Salmonella typhimurium (1978) (140)
Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump (1996) (138)
Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups (1990) (136)
OmpA protein of Escherichia coli outer membrane occurs in open and closed channel forms. (1994) (135)
Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra (1996) (134)
Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams (1985) (133)
Export of autotransported proteins proceeds through an oligomeric ring shaped by C‐terminal domains (2002) (132)
Purification and properties of Pseudomonas aeruginosa porin. (1983) (128)
Optimized Nile Red Efflux Assay of AcrAB-TolC Multidrug Efflux System Shows Competition between Substrates (2010) (125)
Sequence of the malK gene in E.coli K12. (1982) (124)
Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli (2013) (124)
Role of permeability barriers in resistance to β-lactam antibiotics (1985) (123)
Overproduction, solubilization, and reconstitution of the maltose transport system from Escherichia coli. (1990) (123)
Outer membrane of Salmonella XIV. Reduced transmembrane diffusion rates in porin-deficient mutants. (1977) (123)
Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway (2006) (121)
Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosa (1996) (119)
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli (2009) (117)
Galactose-sensitive mutants of Salmonella. I. Metabolism of galactose. (1961) (117)
Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels (2013) (117)
Galactose-sensitive mutants of Salmonella. II. Bacteriolysis induced by galactose. (1961) (116)
Extended deletions in the histidine-rough-B region of the Salmonella chromosome. (1967) (115)
A MATE Family Multidrug Efflux Transporter Pumps out Fluoroquinolones in Bacteroides thetaiotaomicron (2001) (114)
Proteins forming large channels from bacterial and mitochondrial outer membranes: porins and phage lambda receptor protein. (1983) (112)
Covalently Linked Trimer of the AcrB Multidrug Efflux Pump Provides Support for the Functional Rotating Mechanism (2008) (111)
Isolation of outer membranes. (1994) (109)
SEMIROUGH STRAINS OF SALMONELLA. (1965) (108)
Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors (2014) (108)
Regulation of the maltose transport system of Escherichia coli by the glucose-specific enzyme III of the phosphoenolpyruvate-sugar phosphotransferase system. Characterization of inducer exclusion-resistant mutants and reconstitution of inducer exclusion in proteoliposomes. (1990) (108)
Chimeric Analysis of AcrA Function Reveals the Importance of Its C-Terminal Domain in Its Interaction with the AcrB Multidrug Efflux Pump (2003) (106)
Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa (1989) (104)
Lipopolysaccharide structure required for in vitro trimerization of Escherichia coli OmpF porin (1991) (102)
Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding. (2001) (100)
Galactose-sensitive Mutants of Salmonella (1959) (100)
Maltose transport system of Escherichia coli: An ABC‐type transporter (1994) (97)
OmpA Is the Principal Nonspecific Slow Porin of Acinetobacter baumannii (2012) (97)
Transport across the bacterial outer membrane (1993) (92)
A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates. (1999) (91)
Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins (1991) (91)
Loss of OmpC porin in a strain of Salmonella typhimurium causes increased resistance to cephalosporins during therapy. (1987) (91)
Contributions of the AmpC β-Lactamase and the AcrAB Multidrug Efflux System in Intrinsic Resistance of Escherichia coli K-12 to β-Lactams (2000) (91)
Interplay of cell wall barrier and beta-lactamase activity determines high resistance to beta-lactam antibiotics in Mycobacterium chelonae (1991) (90)
Substrate path in the AcrB multidrug efflux pump of Escherichia coli (2010) (90)
Maltose transport and starch binding in phage-resistant point mutants of maltoporin. Functional and topological implications. (1988) (89)
Overview of bacterial ABC transporters. (1998) (88)
Threonine-978 in the Transmembrane Segment of the Multidrug Efflux Pump AcrB of Escherichia coli Is Crucial for Drug Transport as a Probable Component of the Proton Relay Network (2006) (87)
Porins of Brucella species (1984) (85)
Pseudomonas aeruginosa Porin OprF Exists in Two Different Conformations* (2006) (83)
Structural and Functional Analyses of the Major Outer Membrane Protein of Chlamydia trachomatis (2007) (83)
Biochemistry and Regulation of a NovelEscherichia coli K-12 Porin Protein, OmpG, Which Produces Unusually Large Channels (1998) (83)
Asymmetric localization of lipopolysaccharides on the outer membrane of Salmonella typhimurium (1980) (82)
The role of outer membrane and efflux pumps in the resistance of gram-negative bacteria. Can we improve drug access? (1998) (81)
Permeability of the mycobacterial cell wall. (1991) (80)
Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coli (2010) (77)
In vitro trimerization of OmpF porin secreted by spheroplasts of Escherichia coli. (1990) (77)
Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC (2016) (76)
Antibiotic efflux mechanisms. (1999) (72)
Outer membrane of Salmonella typhimurium. Electron spin resonance studies. (1977) (72)
Protein I of Neisseria gonorrhoeae outer membrane is a porin (1981) (72)
Biosynthesis of Cell Wall Lipopolysaccharide in Mutants of Salmonella V. A Mutant of Salmonella typhimurium Defective in the Synthesis of Cytidine Diphosphoabequose (1969) (70)
Diffusion of solutes through channels produced by phage lambda receptor protein of Escherichia coli: inhibition by higher oligosaccharides of maltose series. (1980) (70)
Microdermatology: Cell Surface in the Interaction of Microbes with the External World (1999) (67)
A Mycobacterium smegmatis mutant with a defective inositol monophosphate phosphatase gene homolog has altered cell envelope permeability (1997) (67)
RND transporters in the living world. (2018) (67)
Restoring permeability barrier function to outer membrane. (2005) (67)
The C-Terminal Domain of Salmonella enterica Serovar Typhimurium OmpA Is an Immunodominant Antigen in Mice but Appears To Be Only Partially Exposed on the Bacterial Cell Surface (2003) (66)
Determinants of OmpF porin antigenicity and structure. (1990) (64)
How are the ABC transporter (2016) (64)
Site-Directed Disulfide Cross-Linking Shows that Cleft Flexibility in the Periplasmic Domain Is Needed for the Multidrug Efflux Pump AcrB of Escherichia coli (2007) (63)
Outer membrane of Salmonella typhimurium. Identification of proteins exposed on cell surface. (1977) (63)
Interaction between maltose‐binding protein and the membrane‐associated maltose transporter complex in Escherichia coli (1992) (62)
Ligand‐transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay (2007) (62)
Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump (2016) (62)
Outer membrane of gram-negative bacteria. XVII. Secificity of transport process catalyzed by the lambda-receptor protein in Escherichia coli. (1977) (61)
Rough Mutants of Salmonella Typhimurium (3) Enzymatic Synthesis of Nucleotide-Sugar Compounds (1964) (61)
Active Efflux of Norfloxacin byBacteroides fragilis (1998) (60)
Permeability of the outer membrane of bacteria. (1979) (60)
Partitioning of hydrophobic probes into lipopolysaccharide bilayers. (1990) (59)
Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors. (2015) (59)
Extensive homology between membrane-associated components of histidine and maltose transport systems of Salmonella typhimurium and Escherichia coli. (1982) (59)
Two modes of ligand binding in maltose-binding protein of Escherichia coli. Electron paramagnetic resonance study of ligand-induced global conformational changes by site-directed spin labeling. (1997) (57)
It takes three to tango (2002) (56)
Two modes of ligand binding in maltose-binding protein of Escherichia coli. Functional significance in active transport. (1997) (56)
3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm. (2003) (55)
Studies on the biosynthesis of cell-wall polysaccharide in mutant strains of Salmonella. I. (1962) (55)
Biosynthesis of Saccharides From Glycopyranosyl Esters of Nucleoside Pyrophosphates “Sugar Nucleotides” (1971) (55)
Targeting of porin to the outer membrane of Escherichia coli. Rate of trimer assembly and identification of a dimer intermediate. (1988) (55)
Active efflux of antimicrobial agents in wild-type strains of enterococci (1997) (52)
Two modes of ligand binding in maltose-binding protein of Escherichia coli. Correlation with the structure of ligands and the structure of binding protein. (1997) (51)
Quantitative lipid composition of cell envelopes of Corynebacterium glutamicum elucidated through reverse micelle extraction (2011) (51)
Maltose transport in membrane vesicles of Escherichia coli is linked to ATP hydrolysis. (1989) (50)
Persistence of segregated phospholipid domains in phospholipid--lipopolysaccharide mixed bilayers: studies with spin-labeled phospholipids. (1981) (50)
Specificity of the glucose channel formed by protein D1 of Pseudomonas aeruginosa. (1988) (49)
Identification of a cytoplasmic membrane-associated component of the maltose transport system of Escherichia coli. (1980) (49)
Bacterial resistance to antibiotics as a function of outer membrane permeability. (1988) (49)
Existence and purification of porin heterotrimers of Escherichia coli K12 OmpC, OmpF, and PhoE proteins. (1989) (49)
Genetic Determination of Enzymes Synthesizing O-Specific Sugars of Salmonella Lipopolysaccharides (1966) (48)
High Salt Concentrations Increase Permeability through OmpC Channels of Escherichia coli* (2014) (46)
Multidrug Efflux Pump MdtBC of Escherichia coli Is Active Only as a B2C Heterotrimer (2009) (46)
Physical interaction between the phage lambda receptor protein and the carrier-immobilized maltose-binding protein of Escherichia coli. (1981) (45)
Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB. (2013) (45)
Trimerization of an in vitro synthesized OmpF porin of Escherichia coli outer membrane. (1991) (45)
Mutation in Serratia marcescens AmpC β-Lactamase Producing High-Level Resistance to Ceftazidime and Cefpirome (2001) (45)
Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump. (2001) (44)
CHAPTER 4 – Outer Membrane Permeability of Pseudomonas aeruginosa (1986) (44)
Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli (2011) (43)
Glucosylation of lipopolysaccharide in Salmonella: biosynthesis of O antigen factor 12 2 . I. Over-all reaction. (1971) (42)
Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa (2012) (42)
Formation of phage receptors induced by galactose in a galactose-sensitive mutant of Salmonella. (1960) (41)
Glucosylation of lipopolysaccharide in Salmonella: biosynthesis nof O antigen factor n12 2 . II. Structure of the lipid intermediate. (1971) (41)
Membrane Permeability and Transport in Mycobacterium tuberculosis (1994) (41)
Consequences of deletion mutations joining two operons of opposite polarity. (1969) (38)
Galactose mutants of Salmonella typhimurium. (1961) (38)
Amino acid sequence homology among the major outer membrane proteins of Escherichia coli. (1984) (37)
Pleiotropic transport mutants of Escherichia coli lack porin, a major outer membrane protein (1977) (37)
Structure of cell wall lipopolysaccharide from Salmonella typhimurium. I. Linkage between o side chains and R core. (1969) (36)
Activity of the carbapenem panipenem and role of the OprD (D2) protein in its diffusion through the Pseudomonas aeruginosa outer membrane (1993) (36)
Active transport of maltose in membrane vesicles obtained from Escherichia coli cells producing tethered maltose-binding protein (1989) (36)
Outer membranes of gram-negative bacteria. XV. Transmembrane diffusion rates in lipoprotein-deficient mutants of Escherichia coli (1977) (32)
Nonspecific and specific diffusion channels in the outer membrane of Escherichia coli. (1980) (32)
Specificity of diffusion channels produced by X phage receptor protein of Escherichia coli (liposomes/reconstitution/outer membrane/facilitated diffusion/maltose) (1980) (31)
Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance (1989) (29)
Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli. (2012) (28)
Isolation of cytidine diphosphate 3,6-dideoxyhexoses from Salmonella. (1961) (28)
How do exported proteins and antibiotics bypass the periplasm in Gram-negative bacterial cells? (2000) (27)
BIOSYNTHESIS OF O‐ANTIGENIC POLYSACCHARIDES IN SALMONELLA (1966) (27)
Biosynthesis of cell wall lipopolysaccharide in gram-negative enteric bacteria. (1968) (27)
BIOSYNTHESIS OF CELL WALL POLYSACCHARIDE IN MUTANT STRAINS OF SALMONELLA. IV. SYNTHESIS OF S-SPECIFIC SIDE-CHAIN. (1965) (26)
Biosynthesis of uridine diphosphate N-acetylmannosaminuronic acid in rff mutants of Salmonella tryphimurium (1978) (26)
Immunochemical structure of the OmpD porin from Salmonella typhimurium. (1996) (26)
Role of permeability barriers in resistance to beta-lactam antibiotics. (1985) (26)
Structure of cell wall lipopolysaccharide from Salmonella typhimurium. IV. Anomeric configuration of L-rhamnose residues and its taxonomic implications. (1970) (25)
Biosynthesis of cell wall polysaccharide in mutant strains of Salmonella. 3. Transfer of L-rhamnose and D-galactose. (1965) (25)
Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin. (2015) (24)
Biosynthesis of T1 Antigen in Salmonella: Origin of d-Galactofuranose and d-Ribofuranose Residues (1971) (24)
Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin (2000) (24)
Editorial: Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria (2016) (24)
Lipopolysaccharide in the taxonomy of Enterobacteriaceae (1970) (23)
Biogenesis of prokaryotic pores. (1990) (23)
Pseudomonas aeruginosa PORIN OprF: PROPERTIES OF THE CHANNEL (2006) (23)
Biosynthesis of thymidine diphosphate L-rhamnose in Escherichia coli K-12. (1965) (23)
How are the ABC transporters energized? (2002) (23)
Structure and functions of the cell envelope of gram-negative bacteria. (1988) (22)
Formation of ‘Protoplasts’ in Mutant Strains of Salmonella induced by Galactose (1959) (20)
Biosynthesis of enterobacterial common antigen requires dTDPglucose pyrophosphorylase determined by a Salmonella typhimurium rfb gene and a Salmonella montevideo rfe gene (1986) (19)
Phospholipid as a possible component of carrier system in beta-galactoside permease of Escherichia coli. (1962) (19)
Mechanistic parallels in bacterial and human multidrug efflux transporters. (2002) (18)
Enterobacterial common antigen in rfb deletion mutants of Salmonella typhimurium (1976) (18)
In Pseudomonas aeruginosa ethidium bromide does not induce its own degradation or the assembly of pumps involved in its efflux. (2004) (18)
[Bacterial lipopolysaccharides]. (1967) (18)
Transport through the outer membrane of bacteria. (1986) (18)
Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays. (2016) (18)
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses in Salmonella. (1966) (18)
X-ray diffraction studies of outer membranes of Salmonella typhimurium. (1979) (18)
Crossing the envelope: how cephalosporins reach their targets. (2000) (17)
Structure of cell wall lipopolysaccharide from Salmonella typhimurium. Further studies on the linkage between O side chains and R core. (1970) (16)
Stoichiometry of maltodextrin-binding sites in LamB, an outer membrane protein from Escherichia coli (1991) (15)
A mutant form of maltose-binding protein of Escherichia coli deficient in its interaction with the bacteriophage lambda receptor protein (1983) (15)
The role of ATP as the energy source for maltose transport in Escherichia coli. (1990) (14)
Factors Affecting the Folding of Pseudomonas aeruginosa OprF Porin into the One-Domain Open Conformer (2010) (14)
Two Modes of Ligand Binding in Maltose-binding Protein ofEscherichia coli (1997) (13)
Role of ,B-Lactam Hydrolysis in the Mechanism of Resistance of a 3-Lactamase-Constitutive Enterobacter cloacae Strain to Expanded-Spectrum r-Lactams (13)
UV difference spectroscopy of ligand binding to maltose‐binding protein (1992) (13)
Components of Boucerosia aucheriana Decne. (1967) (12)
Phage lambda receptor protein from Escherichia coli (1978) (12)
Uptake of iron-siderophore complexes across the bacterial outer membrane. (1993) (12)
Bacteriophage Lambda Receptor Protein in Escherichia coli K-12: Lowered Affinity of Some Mutant Proteins for Maltose-Binding Protein In Vitro (1983) (12)
Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli (2015) (12)
Preparation and reconstitution of membrane-associated maltose transporter complex of Escherichia coli. (1998) (11)
Studies on the biosynthesis of cell wall polysaccharide in mutant strains of Salmonella. II. (1962) (11)
Accessibility of lysyl residues of Escherichia coli B/r porin (OmpF) to covalent labeling reagents of different sizes. An approach for a three-dimensional structure of a channel-forming protein. (1985) (11)
Molecular basis of antimicrobial resistance in non-typable Haemophilus influenzae. (1997) (11)
The effect of mutation in a structural gene on the inducibility of the enzymes controlled by other genes of the same operon. (1961) (11)
Site-directed disulfide cross-linking to probe conformational changes of a transporter during its functional cycle: Escherichia coli AcrB multidrug exporter as an example. (2010) (10)
Microbial Biotechnology: Microbial Biotechnology (2007) (10)
OmpA/OprF: Slow Porins or Channels Produced by Alternative Folding of Outer Membrane Proteins (2005) (10)
Contribution of the cell-surface-associated enzyme in the Zimmermann-Rosselet assay of outer membrane permeability of beta-lactam antibiotics (1991) (10)
Functional reconstitution of lens gap junction proteins into proteoliposomees (2005) (9)
Stimulation of glutamine transport by osmotic stress in Escherichia coli K-12 (1990) (9)
Antimicrobial Drug Efflux Pumps in Escherichia coli (2016) (9)
Role, Structure, and Function of Multidrug Efflux Pumps in Gram-Negative Bacteria (2005) (9)
Physical interaction between lipid A and phospholipids: a study with spin-labeled phospholipids. (1984) (8)
Structure of cell wall lipopolysaccharide from Salmonella typhimurium. Structure of lipopolysaccharide from a Semirough mutant. (1970) (8)
Evolutionary origins of multidrug and drug‐specific efflux pumps in bacteria (1998) (8)
Porins ofBrucella Species (1984) (8)
ISOLATION OF URIDINE DIPHOSPHOGALACTOSE FROM ESCHERICHIA COLI MUTANT CELLS. (1964) (8)
Biosynthesis of T1 Antigen in Salmonella: Biosynthesis in a Cell-Free System (1971) (8)
Cell Wall: Physical Structure and Permeability (2009) (7)
Contributions of the AmpC b -Lactamase and the AcrAB Multidrug Efﬂux System in Intrinsic Resistance of Escherichia coli K-12 to b -Lactams (2000) (6)
An NMR study of ligand binding by maltodextrin binding protein. (1998) (6)
Diffusion of 1-Lactam Antibiotics Through the Porin Channels of Escherichia coli K-12 (6)
Christian Raetz: scientist and friend extraordinaire. (2013) (5)
Proteins Forming Large Channels in Biological Membranes (1982) (5)
To the happy few. (2011) (5)
Microbial Biotechnology: Microbial Polysaccharides and Polyesters (2007) (5)
Two Modes of Ligand Binding in Maltose-binding Protein ofEscherichia coli (1997) (4)
An NMR study of ligand binding by maltodextrin binding protein (1998) (3)
Two Modes of Ligand Binding in Maltose-binding Protein ofEscherichia coli (1997) (3)
, Etsuko Channels OmpG , Which Produces Unusually Large K-12 Porin Protein , Escherichia coli Biochemistry and Regulation of a Novel (1998) (3)
Acinetobacter baumanii Compared with Those of AcrAB-TolC (2014) (2)
Microbial Biotechnology: Ethanol (2007) (2)
High-Level Fluoroquinolone-Resistant Clinical Isolates ofEscherichia coli Overproduce Multidrug Efflux Protein AcrA (2001) (2)
Microbial Biotechnology: Microbial Biotechnology: Scope, Techniques, Examples (2007) (2)
An Automatic Detection System for Anomalous Objects in Excavating Tunnels (1993) (2)
Structure of Cell Wall Lipopolysaccharide from Salmonella typhimurium IV. Anomeric Configuration of l-Rhamnose Residues and Its Taxonomic Implications (1973) (2)
Outer Membrane Permeability of Gram-Negative Bacteria in their Interaction with the Outside World (1984) (2)
P cycle cannot be a general mechanism for energy production, and it does not sensitize bacteria toward aminoglycosides (2019) (2)
Microbial Biotechnology: Biocatalysis in Organic Chemistry (2007) (2)
Langmuir Monolayers of Bacterial Outer Membranes (2013) (1)
Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin (2013) (1)
Molecular Insights into Compound-Transporter Interactions: The Case of Inhibitors of Gram-Negative Bacteria Efflux Pumps (2017) (1)
Biosynthesis ofT1Antigen inSalmonella: Biosynthesis inaCell-Free System (1971) (1)
Chapter 27 Diffusion of inhibitors across the cell wall (1994) (1)
Microbial Biotechnology: Biomass (2007) (1)
[19] Isolation of epimeraseless mutants (1966) (1)
Hydrophilic Solutes in Mycobacterium chelonei (2005) (1)
Cell-Free System (2020) (1)
Determining Ligand Path Through a Major Drug Transporter, AcrB, in Escherichia coli. (2018) (0)
Site-Directed Disulﬁde Cross-Linking Shows that Cleft Flexibility in the Periplasmic Domain Is Needed for the Multidrug Efﬂux Pump AcrB of Escherichia coli (cid:1) (2007) (0)
Contributions of AmpC beta-lactamase and AcrAB efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactamase (2000) (0)
Microbial Biotechnology: Plant–Microbe Interactions (2007) (0)
CRYSTAL STRUCTURE OF MALTOTETRAITOL BOUND TO CLOSED-FORM MALTODEXTRIN BINDING PROTEIN (2001) (0)
Amino acid sequence homology am, proteins of Escherichia coli (2017) (0)
Hiroshi Nikaido and to Aminoglycosides aeruginosa Pseudomonas the Natural Resistance of Involvement of an Active Efflux System in (1999) (0)
E. coli, the USDA, and the CDC [3] (2005) (0)
Pseudomonas aeruginosa. proteins OmpA of Escherichia coli and OprF of Secondary structure of the outer membrane (2013) (0)
, with Other Inhibitors Multidrug Efflux Pump and Comparison Inhibition of Escherichia coli AcrB Molecular Mechanism of MBX 2319 (2014) (0)
High-Level Fluoroquinolone-Resistant Clinical Isolates of Overproduce Multidrug Efflux Protein AcrA. (2001) (0)
Kinetic Parameters of Efﬂux of Penicillins by the Multidrug Efﬂux Transporter AcrAB-TolC of Escherichia coli (cid:1) (2010) (0)
Microbial Biotechnology: Preamble (2007) (0)
Vestibules Are Part of the Substrate Path in the Multidrug Efﬂux Transporter AcrB of Escherichia coli (cid:1) (2011) (0)
The Structural Role of Lipid Domain Modifications in Antimicrobial Resistance for Salmonella Enterica Serovar Typhimurium (2014) (0)
Microbial Biotechnology: Microbial Diversity (2007) (0)
Microbial Biotechnology: The World of “Omics”: Genomics, Transcriptomics, Proteomics, and Metabolomics (2007) (0)
[The cell cycle-dependent protein synthesis in Escherichia coli (author's transl)]. (1980) (0)
Purification and functional characterization of mutant LamB proteins. (1982) (0)
Hiroshni Nikaido, MD, of University of California, Berkeley, Wins Bristol-Meyers Squibb Infectious Diseases Research Award (2004) (0)
Proceedings of the 14th Symposium on Bacterial Toxins-International Session (1967) (0)
Microbial Biotechnology: Secondary Metabolites: Antibiotics and More (2007) (0)
contributing factor to beta-lactam resistance. Pseudomonas aeruginosa: active efflux as a Role of efflux pump(s) in intrinsic resistance of (2013) (0)
Can Penicillins and Other (cid:98) -Lactam Antibiotics Be Used To Treat Tuberculosis? (1995) (0)
Herman M. Kalckar (1993) (0)
Microbial Biotechnology: Primary Metabolites: Organic Acids and Amino Acids (2007) (0)
of the AcrB Multidrug Efflux Pump Structural Basis of Multiple Drug-Binding Capacity (2007) (0)
lrnrnunochernical structure of the OmpD porin f rorn Salmonella typhimurium (2008) (0)
[Successive assimilation of amino acids. (2)]. (1955) (0)
Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efﬂux pump inhibitors (2015) (0)
Biosynthesis of the 0-Antigenic Side-Chains of Lipopolysaccharide in Salmonella -Its Biochemistry and Genetics (Abstract) (1967) (0)
Microbial Biotechnology: Plate section (2007) (0)
Porin fromRhodopseudomonas sphaeroides (1984) (0)
Enterobacterial CommonAntigen inribDeletion Mutants of Salmonella typhimurium (1976) (0)
Drug Resistance in the Evolution of Pathogenic Bacteria (1999) (0)
Seiji Kojima and Hiroshi Nikaido Escherichia coli High Salt Concentrations Increase Permeability through OmpC Channels (2014) (0)
Outer Membrane, Gram-Negative Bacteria (2019) (0)
Active Efﬂux of Fluoroquinolones in Mycobacterium smegmatis Mediated by LfrA, a Multidrug Efﬂux Pump (1996) (0)
Microbial Biotechnology: Environmental Applications (2007) (0)
Hiroshi Nikaido Deoxycholate Its Resistance to Novobiocin and and Increases Escherichia coli Cluster in ) Transporter Gene mdtABCD ( yegMNOB System Activates Transcription of the The BaeSR Two-Component Regulatory (2002) (0)
Structural Basis of Multidrug transport by the AcrB Multidrug Efflux Pump (2005) (0)
Covalently Linked Trimers of RND (Resistance-Nodulation-Division) Efflux Transporters to Study Their Mechanism of Action: Escherichia coli AcrB Multidrug Exporter as an Example. (2018) (0)
Microbial Biotechnology: Production of Proteins in Bacteria and Yeast (2007) (0)
Microbial Biotechnology: Bacillus thuringiensis (Bt) Toxins: Microbial Insecticides (2007) (0)
CirandFiuProteins intheOuterMembraneofEscherichia coli Catalyze Transport ofMonomeric Catechols: Studywith1-Lactam Antibiotics Containing Catechol andAnalogous Groups (1990) (0)
Microbial Biotechnology: Recombinant and Synthetic Vaccines (2007) (0)
[Biological studies of mycoplasma isolated from the bronchial tract of mice. (1)]. (1966) (0)
The Unveiling of Pathogenesis (1995) (0)
Aminoacidsequence homology amongthemajoroutermembrane proteins ofEscherichia coli (1984) (0)
Interaction between maltose‐binding protein and the membrane‐associated maltose transporter complex in Escherichia coli (1992) (0)
Interaction of Novobiocin with Salmonella Sp Outer Membrane (2014) (0)

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