H. Robert Horvitz
#1,535
Most Influential Person
American biologist
H. Robert Horvitz's AcademicInfluence.com Rankings
H. Robert Horvitzbiology Degrees
Biology
#54
World Rank
#100
Historical Rank
#34
USA Rank
Developmental Biology
#18
World Rank
#21
Historical Rank
#9
USA Rank
Genetics
#29
World Rank
#48
Historical Rank
#20
USA Rank
Download Badge
Biology
Why Is H. Robert Horvitz Influential?
(Suggest an Edit or Addition)H. Robert Horvitz is a professor of biology and member of the McGovern Institute for Brain Research, an investigator for the Howard Hughes Medical Institute, chair of the Board of Trustees of the Society for Science & the Public, and a member of the USA Science and Engineering Festival’s Advisory Board. He studied mathematics at the Massachusetts Institute of Technology and earned a Ph.D. in biology from Harvard University. He completed his postdoctoral studies at the Laboratory of Molecular Biology in Cambridge.
Horvitz is best known for his work researching the nematode worm Caenorhabditis elegans. His work with Sydney Brenner and John E. Sulston earned the trio the 2002 Nobel Prize in Physiology or Medicine. His body of work on C. elegans has tied the nematode to diseases such as cancer and neurodegenerative diseases such as amyotrophic lateral sclerosis and has revealed important data about the genetic programming that controls cell death, also known as apoptosis.
Besides the Nobel Prize, Horvitz has received numerous honors, including the Gairdner Foundation International Award, the Grand Prix Charles-Leopold Mayer from the French Academy of Sciences, the Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience, the Genetics Society of America Medal, and the UK Genetics Society Mendel Medal.
Featured in Top Influential Biologists Today
According to Wikipedia, Howard Robert Horvitz ForMemRS NAS AAA&S APS NAM is an American biologist best known for his research on the nematode worm Caenorhabditis elegans, for which he was awarded the 2002 Nobel Prize in Physiology or Medicine, together with Sydney Brenner and John E. Sulston, whose "seminal discoveries concerning the genetic regulation of organ development and programmed cell death" were "important for medical research and have shed new light on the pathogenesis of many diseases".
H. Robert Horvitz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Papers
- MicroRNA expression profiles classify human cancers (2005) (9561)
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis (1993) (6694)
- The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans (2000) (4911)
- Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. (1977) (3411)
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis (2009) (2366)
- Mechanisms and functions of cell death. (1991) (2090)
- Genetic control of programmed cell death in the nematode C. elegans (1986) (1768)
- MicroRNA Expression in Zebrafish Embryonic Development (2005) (1582)
- C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2 (1994) (1220)
- Odorant-selective genes and neurons mediate olfaction in C. elegans (1993) (1093)
- C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway (2000) (932)
- Microarray analysis of microRNA expression in the developing mammalian brain (2004) (806)
- The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. (2000) (773)
- Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS. (1979) (771)
- Heterochronic mutants of the nematode Caenorhabditis elegans. (1984) (771)
- Egg-laying defective mutants of the nematode Caenorhabditis elegans. (1983) (723)
- Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans (1991) (658)
- The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9 (1998) (656)
- Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. (1999) (647)
- EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins (1996) (580)
- Serotonin and octopamine in the nematode Caenorhabditis elegans. (1982) (577)
- CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans (2001) (566)
- The lin-12 locus specifies cell fates in caenorhabditis elegans (1983) (562)
- Genetic control of programmed cell death in the nematode Caenorhabditis elegans. (1999) (548)
- The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. (1990) (535)
- Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II (1990) (530)
- Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis (1997) (530)
- The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. (2005) (515)
- Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. (1985) (503)
- Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability (2007) (501)
- Genetics of programmed cell death in C. elegans: past, present and future. (1998) (499)
- A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons (1988) (493)
- Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein (1995) (484)
- Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. (1991) (473)
- The GABAergic nervous system of Caenorhabditis elegans (1993) (467)
- CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans (2000) (440)
- A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. (1993) (439)
- Control of larval development by chemosensory neurons in Caenorhabditis elegans. (1991) (419)
- Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells (2013) (413)
- Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction (1990) (406)
- Programmed cell death in Caenorhabditis elegans. (1994) (404)
- C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 (1998) (403)
- Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. (1980) (398)
- The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. (1992) (387)
- C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span (2006) (375)
- Caenorhabditis elegans rab-3 Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of Vesicles (1997) (367)
- A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia (2006) (359)
- Tyramine Functions Independently of Octopamine in the Caenorhabditis elegans Nervous System (2005) (358)
- Phagocytosis promotes programmed cell death in C. elegans (2001) (355)
- Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. (1990) (352)
- The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. (1996) (350)
- lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48 (1998) (348)
- EAT-4, a Homolog of a Mammalian Sodium-Dependent Inorganic Phosphate Cotransporter, Is Necessary for Glutamatergic Neurotransmission in Caenorhabditis elegans (1999) (336)
- UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. (1999) (329)
- Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. (2000) (327)
- The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans (1995) (318)
- Genes required for GABA function in Caenorhabditis elegans (1993) (318)
- Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans (1995) (311)
- The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors (1988) (299)
- The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters (1998) (294)
- A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans (1987) (287)
- A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant (1987) (286)
- Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. (1981) (282)
- EGG-LAYING DEFECTIVE MUTANTS OF THE NEMATODE (1983) (277)
- Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability (2010) (277)
- Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration (2008) (274)
- The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. (2000) (270)
- The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. (1994) (266)
- The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. (1989) (265)
- The Caenorhabditis elegans Gene unc-25Encodes Glutamic Acid Decarboxylase and Is Required for Synaptic Transmission But Not Synaptic Development (1999) (259)
- Genes necessary for directed axonal elongation or fasciculation in C. elegans (1992) (258)
- Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. (2001) (258)
- Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling (2000) (256)
- Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. (1996) (255)
- Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. (2000) (248)
- Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein (1994) (247)
- The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans (1989) (243)
- The engulfment process of programmed cell death in caenorhabditis elegans. (2004) (239)
- Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva (1991) (238)
- The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene (1999) (233)
- Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice (2015) (224)
- Chemosensory cell function in the behavior and development of Caenorhabditis elegans. (1990) (221)
- The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. (1996) (219)
- Mutations in the α1 subunit of an L‐type voltage‐activated Ca2+ channel cause myotonia in Caenorhabditis elegans (1997) (215)
- A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. (1994) (213)
- The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously (1995) (209)
- The genetics of programmed cell death in the nematode Caenorhabditis elegans. (1994) (206)
- Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis (2003) (198)
- unc-93(e1500): A behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype. (1980) (198)
- Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis (2009) (197)
- The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. (1987) (194)
- unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. (2001) (192)
- An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites (1995) (191)
- Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2 (1994) (190)
- The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. (2012) (186)
- The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. (2001) (185)
- dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. (2001) (180)
- Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3 (1995) (179)
- Worms, Life, and Death (Nobel Lecture) (2003) (177)
- Two C. elegans genes control the programmed deaths of specific cells in the pharynx. (1991) (177)
- NUC-1, a caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis. (2000) (176)
- Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2 (1996) (174)
- MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans (2000) (172)
- Coordinated Transcriptional Regulation of the unc-25Glutamic Acid Decarboxylase and the unc-47 GABA Vesicular Transporter by the Caenorhabditis elegans UNC-30 Homeodomain Protein (1999) (168)
- Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKM z (2009) (165)
- The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. (1995) (165)
- Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans. (1986) (164)
- An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor (1996) (161)
- Mutations in the Caenorhabditis elegans Serotonin Reuptake Transporter MOD-5 Reveal Serotonin-Dependent and -Independent Activities of Fluoxetine (2001) (160)
- Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development (2007) (157)
- Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. (2003) (152)
- A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. (2004) (146)
- The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (1997) (143)
- Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro * (1997) (143)
- Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex (2006) (139)
- Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying. (1989) (139)
- A uniform genetic nomenclature for the nematode Caenorhabditis elegans (1979) (138)
- The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions. (1994) (134)
- Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor (1997) (132)
- lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions. (1988) (132)
- A first insight into the molecular mechanisms of apoptosis (2004) (131)
- The ced-8 gene controls the timing of programmed cell deaths in C. elegans. (2000) (130)
- Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. (1983) (130)
- Superoxide Dismutase Concentration and Activity in Familial Amyotrophic Lateral Sclerosis (1995) (130)
- The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. (1993) (126)
- Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis (1998) (123)
- SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose (2001) (122)
- A Neuronal Acetylcholine Receptor Regulates the Balance of Muscle Excitation and Inhibition in Caenorhabditis elegans (2009) (122)
- Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans (2010) (122)
- Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway. (1999) (121)
- sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. (1999) (120)
- The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. (1999) (120)
- The genetic control of cell lineage during nematode development. (1984) (118)
- Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans. (1993) (115)
- Light and Hydrogen Peroxide Inhibit C. elegans Feeding through Gustatory Receptor Orthologs and Pharyngeal Neurons (2015) (114)
- Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase. (1998) (114)
- clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. (1998) (111)
- The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types (2002) (110)
- ISOLATION AND GENETIC CHARACTERIZATION OF CELL-LINEAGE MUTANTS OF THE NEMATODE (1980) (109)
- Ligand-Gated Chloride Channels Are Receptors for Biogenic Amines in C. elegans (2009) (109)
- FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans (2008) (108)
- Gonadal cell lineages of the nematode Panagrellus redivivus and implications for evolution by the modification of cell lineage. (1981) (108)
- NOBEL LECTURE: Worms, Life and Death (2003) (108)
- Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. (1989) (106)
- The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates. (1996) (105)
- Lin-5 Is a Novel Component of the Spindle Apparatus Required for Chromosome Segregation and Cleavage Plane Specification in Caenorhabditis elegans (2000) (101)
- The nematode Caenorhabditis elegans. (1980) (100)
- The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. (1995) (98)
- The ins and outs of programmed cell death during C. elegans development. (1994) (98)
- Replication-Coupled Chromatin Assembly Generates a Neuronal Bilateral Asymmetry in C. elegans (2011) (95)
- CYSL-1 Interacts with the O2-Sensing Hydroxylase EGL-9 to Promote H2S-Modulated Hypoxia-Induced Behavioral Plasticity in C. elegans (2012) (94)
- Postembryonic nongonadal cell lineages of the nematode Panagrellus redivivus: description and comparison with those of Caenorhabditis elegans. (1982) (92)
- Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. (1999) (90)
- The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development (2002) (88)
- Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids (2015) (88)
- Signal transduction during C. elegans vulval induction. (1991) (86)
- The Caenorhabditis elegans Genes sqv-2and sqv-6, Which Are Required for Vulval Morphogenesis, Encode Glycosaminoglycan Galactosyltransferase II and Xylosyltransferase* 210 (2003) (85)
- The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor. (1994) (85)
- Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis. (1994) (84)
- sup-9, sup-10, and unc-93 May Encode Components of a Two-Pore K+ Channel that Coordinates Muscle Contraction in Caenorhabditis elegans (2003) (83)
- Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC‐50 (2007) (81)
- The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. (2007) (80)
- The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein. (1996) (78)
- Axons Degenerate in the Absence of Mitochondria in C. elegans (2014) (76)
- Receptors and Other Signaling Proteins Required for Serotonin Control of Locomotion in Caenorhabditis elegans (2012) (75)
- The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated (2002) (73)
- The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates. (1990) (73)
- C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates (2006) (71)
- Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers. (1994) (70)
- Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans (2012) (69)
- Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins. (1993) (68)
- The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway. (1999) (67)
- Polypeptide bound to the host RNA polymerase is specified by T4 control gene 33. (1973) (67)
- The Caenorhabditis elegans Behavioral Gene unc‐24 Encodes a Novel Bipartite Protein Similar to Both Erythrocyte Band 7.2 (Stomatin) and Nonspecific Lipid Transfer Protein (1996) (66)
- A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis (2018) (66)
- A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. (1991) (62)
- Programmed elimination of cells by caspase-independent cell extrusion in C. elegans (2012) (62)
- Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex (2011) (62)
- Bacteriophage T4 mutants deficient in alteration and modification of the Escherichia coli RNA polymerase. (1974) (62)
- An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways (2013) (60)
- The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells. (1999) (59)
- Identification of three novel mutations in the gene for Cu Zn superoxide dismutase in patients with familial amyotrophic lateral sclerosis (1995) (58)
- Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis (1996) (56)
- Insulin-like signalling to the maternal germline controls progeny response to osmotic stress (2001) (54)
- The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. (2000) (53)
- Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans (2015) (52)
- The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. (2004) (52)
- Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans. (1997) (51)
- The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction (1992) (51)
- The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF (2011) (50)
- C. elegans: Sequence to Biology (1998) (49)
- Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro. (1997) (48)
- The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain. (1991) (48)
- Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans (2013) (47)
- PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans. (2002) (47)
- Control by bacteriophage T4 of two sequential phosphorylations of the alpha subunit of Escherichia coli RNA polymerase. (1974) (47)
- New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. (2003) (46)
- Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure. (1991) (46)
- Neurone differentiation in cell lineage mutants of Caenorhabditis elegans (1982) (46)
- A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans. (1988) (45)
- Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans (2010) (42)
- LIN-61, One of Two Caenorhabditis elegans Malignant-Brain-Tumor-Repeat-Containing Proteins, Acts With the DRM and NuRD-Like Protein Complexes in Vulval Development but Not in Certain Other Biological Processes (2007) (42)
- The multivulva phenotype of certain C. elegans mutants results from defects in two functionally redundant pathways (1989) (42)
- DPL-1 DP, LIN-35 Rb and EFL-1 E2F Act With the MCD-1 Zinc-Finger Protein to Promote Programmed Cell Death in Caenorhabditis elegans (2007) (41)
- Identification and Classification of Genes That Act Antagonistically to let-60 Ras Signaling in Caenorhabditis elegans Vulval Development (2006) (41)
- MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans (2011) (40)
- C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions. (2005) (39)
- C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development (2009) (38)
- IRK-1 Potassium Channels Mediate Peptidergic Inhibition of Caenorhabditis elegans Serotonin Neurons via a Go Signaling Pathway (2012) (37)
- Abl Kinase Inhibits the Engulfment of Apoptotic [corrected] Cells in Caenorhabditis elegans (2009) (37)
- A visible allele of the muscle gene sup-10X of C. elegans. (1986) (36)
- Dominant suppressors of a muscle mutant define an essential gene of Caenorhabditis elegans. (1982) (36)
- 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1 (2010) (34)
- Genes involved in two Caenorhabditis elegans cell-signaling pathways. (1992) (34)
- The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans (2006) (33)
- Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans (2009) (33)
- C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability. (2010) (32)
- C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle. (1986) (32)
- Cytochrome P450 Drives a HIF-Regulated Behavioral Response to Reoxygenation by C. elegans (2013) (32)
- Genetic analysis of Caenorhabditis elegans. (1980) (30)
- Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33 (1998) (26)
- Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans (2016) (26)
- The Translational Regulators GCN-1 and ABCF-3 Act Together to Promote Apoptosis in C. elegans (2014) (25)
- "Joy of the worm". (1990) (24)
- Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans (2010) (24)
- Multiple Levels of Redundant Processes Inhibit Caenorhabditis elegans Vulval Cell Fates (2008) (24)
- Acute care palliative medicine: psychosocial assessment of patients and primary caregivers (1999) (23)
- Correction: Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans (2009) (23)
- lin-8, Which Antagonizes Caenorhabditis elegans Ras-Mediated Vulval Induction, Encodes a Novel Nuclear Protein That Interacts With the LIN-35 Rb Protein (2005) (21)
- The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein That Affects Alternative Splicing (2012) (21)
- Mass spectrometric evidence for neuropeptide-amidating enzymes in Caenorhabditis elegans (2018) (20)
- Caenorhabditis elegans Genes Required for the Engulfment of Apoptotic Corpses Function in the Cytotoxic Cell Deaths Induced by Mutations in lin-24 and lin-33 (2008) (20)
- Three new classes of mutations in the Caenorhabditis elegans muscle gene sup-9. (1993) (19)
- The Conserved VPS-50 Protein Functions in Dense-Core Vesicle Maturation and Acidification and Controls Animal Behavior (2016) (19)
- Mutations in the Caenorhabditis elegans U2AF Large Subunit UAF-1 Alter the Choice of a 3′ Splice Site In Vivo (2009) (18)
- Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response (2018) (18)
- In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans. (2011) (15)
- A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility (2018) (15)
- Chimeric Mutations in the M2 Segment of the 5-Hydroxytryptamine-gated Chloride Channel MOD-1 Define a Minimal Determinant of Anion/Cation Permeability* (2005) (14)
- Replication stress promotes cell elimination by extrusion (2021) (14)
- Wnt and EGF pathways act together to induce C. elegans male hook development. (2009) (14)
- Fate of the nuclear lamina during Caenorhabditis elegans apoptosis. (2002) (13)
- The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage (2017) (13)
- Nematode postembryonic cell lineages. (1982) (12)
- Mutations that perturb vulval invagination in C. elegans. (1997) (12)
- C. elegans discriminates colors to guide foraging (2021) (12)
- The Caenorhabditis elegans Iodotyrosine Deiodinase Ortholog SUP-18 Functions through a Conserved Channel SC-Box to Regulate the Muscle Two-Pore Domain Potassium Channel SUP-9 (2014) (12)
- Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21 (1994) (11)
- The LIN-15A and LIN-56 Transcriptional Regulators Interact to Negatively Regulate EGF/Ras Signaling in Caenorhabditis elegans Vulval Cell-Fate Determination (2011) (10)
- SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans (2011) (10)
- No association of DYNC1H1 with sporadic ALS in a case‐control study of a northern European derived population: A tagging SNP approach (2006) (9)
- H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect (2020) (9)
- Dinucleotide repeat polymorphisms (D21S223 and D21S224) at 21q22.1. (1992) (9)
- SLI-1 Cbl Inhibits the Engulfment of Apoptotic Cells in C. elegans through a Ligase-Independent Function (2012) (8)
- NOVEL NEMATODE AMBER SUPPRESSORS (2003) (8)
- Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor (2018) (7)
- Genetic control of cell death in the nematode C. elegans (1990) (7)
- Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans (2017) (7)
- Genetic Control of Programmed Cell Death in C. Elegans (2001) (6)
- 6 Genetics of Cell Lineage (1988) (6)
- Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. (1990) (6)
- Genetic control of Caenorhabditis elegans cell lineage. (1988) (6)
- C. elegans development (1995) (6)
- Studies of mutations in T4 control genes 33 and 55. (1975) (5)
- The Nobel Prize in Physiology or Medicine 2002 (2003) (4)
- An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction (2020) (3)
- Palliative medicine fellowship: A study of resident choices (2015) (3)
- Phosphorylation of I k Ba Inhibits Its Cleavage by Caspase CPP 32 in Vitro * (1997) (3)
- Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene egl-1 in a Living Neuron Pair in Caenorhabditis elegans (2019) (3)
- APPENDIX 3 Cell Lineage (1988) (3)
- Gene linkage in familial amyotrophic lateral sclerosis: a progress report. (1991) (3)
- Neural Development: Implications for Recovery from Injury (1982) (2)
- Many families of Caenorhabditis elegans microRNAs are not essential for development or viability (2010) (2)
- US immigration order strikes against biotech (2017) (2)
- Cell cycle S-phase arrest drives cell extrusion (2019) (2)
- Two independent dinucleotide repeat polymorphisms at the D21S235 locus (21q22.1). (1992) (2)
- CYSL-1 Interacts with the O[subscript 2]-Sensing Hydroxylase EGL-9 to Promote H[subscript 2]S-Modulated Hypoxia-Induced Behavioral Plasticity in C. elegans (2012) (2)
- Neural cell lineages in the nematode caenorhabditis elegans (1983) (2)
- Biomedical Consulting Agreements: The Good, the Bad, and the Ugly (2012) (1)
- Genetics society of america program and abstracts. (1989) (1)
- Mutations of the glutamate transporter gene EAAT2 do not cause the abnormal EAAT2 transcripts in patients with amyotrophic lateral sclerosis (1997) (1)
- Chronic bleeding secondary to an unresectable duodenal adenocarcinoma controlled with sucralfate and famotidine (1998) (1)
- Obituary: Stanley J. Korsmeyer (1950–2005) (2005) (1)
- Biomedical Consulting Agreements: A Guide for Academics (2012) (1)
- Programmed Cell Death: The Biology of Cell Death in the Nematode Caenorhabditis elegans and Implications for the Understanding and Treatment of Human Brain Injury after Cardiac Surgery (2019) (0)
- Abstracts of papers presented at the 1997 Meeting on Programmed Cell Death, September 17-September 21, 1997 (1997) (0)
- Activity-dependent regulation of the proapoptotic BH3-only gene egl-1 in a living neuron pair in C. elegans (2019) (0)
- Three proteins involved in Caeno invagination are similar to compo (2016) (0)
- Summary The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death (0)
- Worms, Life, and Death (Nobel Lecture). (2003) (0)
- C. elegans mutants defective in neuropeptide amidation enzymes are abnormal in egg-laying behavior (2011) (0)
- Genetic analysis of a caenorhabditis elegans muscle mutant defines a gene with a wild type null phenotype (1982) (0)
- Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans (2016) (0)
- Towards a systematic screen of cytoplasmic dynein-dynactin genes and other candidates for association with motor neuron degeneration disorders by tagging SNP analysis. (2005) (0)
- A Caenorhabditis elegans protein with a PRDM 9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression , sperm (2018) (0)
- Apoptosis in Embryonic Development [1] (2019) (0)
- ESSENTIAL GENE OF CAENORHABDZTIS ELEGANS (1982) (0)
- Genes that control C. elegans cell lineage and cell death (1989) (0)
- The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans (2022) (0)
- Apoptosis in Embryonic Development (2018) (0)
- Author response: The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans (2022) (0)
- Abstracts of papers presented at the 1995 Meeting on Programmed Cell Death, September 20-September 24, 1995 (1995) (0)
- Factors That Influence Neural Development in Nematodes (1982) (0)
- Composes et methodes pour le diagnostic, le traitement et la prevention de la degenerescence neuronale (1994) (0)
- C. elegans germ cell death (1999) (0)
- Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response (2018) (0)
- Book Review: Oncology for palliative medicine (2004) (0)
- Annual Survey of Massachusetts L aw (1957) (0)
- Letter from Paul Berg, Lawrence S. B. Goldstein, H. Robert Horvitz, Thomas D. Pollard, and Harold Varmus to U.S. President Bill Clinton (2000) (0)
- Chapter 7: Article Six: Bulk Transfers (1957) (0)
- When Stockholm Called (2010) (0)
- The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in C. elegans (2021) (0)
- Neurohormonal signalling controls insulin sensitivity and specificity in C. elegans (2017) (0)
This paper list is powered by the following services:
Other Resources About H. Robert Horvitz
What Schools Are Affiliated With H. Robert Horvitz?
H. Robert Horvitz is affiliated with the following schools:
