Harald Tschesche

Harald Tschesche's AcademicInfluence.com Rankings

Harald Tschesche

Biology

#12523

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#16005

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Cell Biology

#666

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#680

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Molecular Biology

#2045

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#2077

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Neuroscience

#2111

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#2170

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Biology

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Harald Tschesche's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells (1997) (515)
Crystal structure of the complex formed by the membrane type 1‐matrix metalloproteinase with the tissue inhibitor of metalloproteinases‐2, the soluble progelatinase A receptor (1998) (333)
Structural properties of matrix metalloproteinases (1999) (320)
Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. (1996) (306)
Unusual solution properties of proline and its interaction with proteins. (1978) (294)
The X‐ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. (1994) (281)
A 25 kDa α2‐microglobulin‐related protein is a component of the 125 kDa form of human gelatinase (1992) (238)
Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2* (1997) (232)
Interleukin‐8 synthesis and the onset of labor (1995) (230)
Insights into MMP‐TIMP Interactions (1999) (203)
Direct activation of human neutrophil procollagenase by recombinant stromelysin. (1993) (173)
Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes. (1986) (160)
Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. (1993) (151)
Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer. (2007) (142)
Matrix Metalloproteinases Collagenase-2, Macrophage Elastase, Collagenase-3, and Membrane Type 1-Matrix Metalloproteinase Impair Clotting by Degradation of Fibrinogen and Factor XII* (2000) (139)
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. (1995) (138)
Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2* (2000) (136)
Human neutrophil collagenase. (1995) (135)
Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor. (1995) (128)
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan. (1994) (118)
Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases (1994) (116)
The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. (2001) (114)
Fragmentation of human polymorphonuclear-leucocyte collagenase. (1993) (112)
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. (2000) (102)
Cellular source, activation and inhibition of dental plaque collagenase. (1995) (100)
Kind of sample as preanalytical determinant of matrix metalloproteinase 2 and 9 and tissue inhibitor of metalloproteinase 2 in blood. (1998) (96)
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure. (2001) (94)
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms. (1990) (94)
Transforming Growth Factor β1 Regulates Tissue Inhibitor of Metalloproteinases—1 Expression in Differentiated Human Articular Chondrocytes (1994) (86)
The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin. (1999) (85)
Biochemistry of natural proteinase inhibitors. (1974) (85)
In vivo inhibition of human neutrophil collagenase (MMP‐8) activity during long‐term combination therapy of doxycycline and non‐steroidal anti‐inflammatory drugs (NSAID) in acute reactive arthritis (1994) (84)
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. (2001) (78)
Latent and active human polymorphonuclear leukocyte collagenases. Isolation, purification and characterisation. (2005) (77)
The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor. (1984) (76)
Modern methods in protein chemistry (1983) (76)
Activation of human neutrophil procollagenase by stromelysin 2. (1996) (75)
A 1H nuclear-magnetic-resonance study of the conformation and the molecular dynamics of the glycoprotein cow-colostrum trypsin inhibitor. (1978) (74)
Inhibition of degranulation of polymorphonuclear leukocytes by angiogenin and its tryptic fragment. (1994) (74)
The effect of nisin on murein synthesis (1980) (73)
Generation of Catalytically Active Granzyme K fromEscherichia coli Inclusion Bodies and Identification of Efficient Granzyme K Inhibitors in Human Plasma* (1999) (73)
ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts. (2002) (72)
The recombinant catalytic domain of membrane‐type matrix metalloproteinase‐1 (MT1‐MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP‐2 (1996) (67)
1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile. (1997) (63)
A new principle of regulation of enzymic activity. Activation and regulation of human polymorphonuclear leukocyte collagenase via disulfide-thiol exchange as catalysed by the glutathione cycle in a peroxidase-coupled reaction to glucose metabolism. (1981) (62)
The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity. (1993) (61)
Synthesis of tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in human hepatoma cells (HepG2) Up‐regulation by interleukin‐6 and transforming growth factor β1 (1992) (61)
Latent collagenase from human polymorphonuclear leucocytes and activation to collagenase by removal of an inhibitor (1980) (60)
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan. (1998) (60)
Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas. (1996) (60)
Proteases and their inhibitors are indicative in gestational disease. (1996) (59)
Immunological characterization of cell‐surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts (1998) (58)
Release of proteinases from stimulated polymorphonuclear leukocytes. Evidence for subclasses of the main granule types and their association with cytoskeletal components. (1991) (57)
ADAM15 decreases integrin αvβ3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion (2005) (57)
Inactivation of human plasma α1‐proteinase inhibitor by human PMN leucocyte collagenase (1990) (56)
The primary structure of porcine glandular kallikreins. (1979) (56)
Degradation of kinins, angiotensins and substance P by polymorphonuclear matrix metalloproteinases MMP 8 and MMP 9. (1994) (53)
Enzyme Linked Immunosorbent Assays (ELISA) for the Quantitative Determination of Human Leukocyte Collagenase and Gelatinase (1989) (53)
Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation. (1995) (52)
Cloning and expression in Pichia pastoris of metalloprotease domain of ADAM 9 catalytically active against fibronectin. (2001) (51)
Stopped-flow kinetics of the resynthesis of the reactive site peptile bond in kallikrein inhibitor (Kunitz) by beta-trypsin. (1978) (49)
Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2. (2007) (49)
Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer. (1995) (48)
Latent collagenase and gelatinase from human neutrophils and their activation. (1992) (48)
Human Keratinocyte Cell Lines Differ in the Expression of the Collagenolytic Matrix Metallo-proteinases-1, -8, and -13 and of TIMP-1 (2000) (47)
The structure of the porcine pancreatic secretory trypsin inhibitor. I. A sequence determination by Edman degradation and mass spectral identification of the p-bromophenyl-thiohydantoins. (1970) (47)
Stability studies on derivatives of the bovine pancreatic trypsin inhibitor. (1987) (46)
Tissue kallikrein effectively activates latent matrix degrading metalloenzymes. (1989) (46)
Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis (1994) (46)
N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8. (2006) (46)
Modulation of the Catalytic Activity of Neutrophil Collagenase MMP-8 on Bovine Collagen I (2002) (44)
Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. (2000) (44)
Influence of flavonoids and vitamins on the MMP- and TIMP-expression of human dermal fibroblasts after UVA irradiation. (2002) (44)
Collagenase in Sjögren's syndrome. (1994) (44)
C-terminal-sequence determination by carboxypeptidase C from orange levels. (1972) (40)
The covalent structure of the elastase inhibitor from Anemonia sulcata--a "non-classical" Kazal-type protein. (1987) (39)
Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis. (1996) (39)
Biological Functions of Proteinases (1979) (38)
Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities. (2004) (38)
Separation of the human leucocyte enzymes alanine aminopeptidase, cathepsin G, collagenase, elastase and myeloperoxidase. (1982) (37)
Autolytic Processing at Glu586-Ser587within the Cysteine-rich Domain of Human Adamalysin 19/Disintegrin-Metalloproteinase 19 Is Necessary for Its Proteolytic Activity* (2002) (36)
Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates (2006) (36)
Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. (2000) (36)
Porcine glandular kallikreins. (1981) (36)
Distribution of extracellular matrix proteins in pterygia: an immunohistochemical study (2004) (35)
The Proteolytic Activity of the Recombinant Cryptic Human Fibronectin Type IV Collagenase from E. coli Expression (2000) (35)
X‐ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors (1995) (34)
Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase) (1992) (34)
Hydrolysis-resynthesis equilibrium of the lysine-15--alanine-16 peptide bond in bovine trypsin inhibitor (Kunitz). (1976) (33)
Evidence for the tissue inhibitor of metalloproteinases-1 (TIMP-1) in human polymorphonuclear leukocytes. (1995) (33)
The expression of angiogenin in tissue samples of different brain tumours and cultured glioma cells. (2000) (33)
Carbon-13 nuclear magnetic resonance studies of the selectively isotope-labeled reactive site peptide bond of the basic pancreatic trypsin inhibitor in the complexes with trypsin, trypsinogen, and anhydrotrypsin. (1980) (32)
Synthesis and analytical use of 3-carboxypropionyl-alanyl-alanyl-valine-4-nitroanilide: a specific substrate for human leukocyte elastase. (1980) (32)
Preparation of active recombinant TIMP-1 from Escherichia coli inclusion bodies and complex formation with the recombinant catalytic domain of PMNL-collagenase. (1993) (31)
Semisynthetic engineering of proteinase inhibitor homologues. (1987) (31)
Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D (1995) (31)
Expression, Purification, Characterization, and X-Ray Analysis of Selenomethionine 215 Variant of Leukocyte Collagenase (1997) (30)
Preparation of chemically 'mutated' aprotinin homologues by semisynthesis. P1 substitutions change inhibitory specificity. (1988) (30)
The influence of localized chemical modifications of the basic pancreatic trypsin inhibitor on static and dynamic aspects of the molecular conformation in solution. (1979) (29)
Angiogenin plasma levels during pregnancy. (1997) (29)
The Amino-Acid Sequence of Isoinhibitor K from Snails (Helix pomatia) (1975) (29)
Tissue inhibitor of metalloproteinase 1, collagenolytic and gelatinolytic activity in loose hip endoprostheses. (1995) (29)
Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. (2006) (28)
A new acrosin inhibitor from boar spermatozoa. (1982) (28)
N-Acetylalanine aminopeptidase, a new enzyme from human erythrocytes. (1981) (27)
Mercurial activation of human polymorphonuclear leucocyte procollagenase. (1991) (27)
Proteinase inhibitors from boar seminal plasma. (1976) (26)
Pregnancy-associated plasma protein-E (PAPP-E). (2000) (25)
A sandwich enzyme immunoassay for the determination of neutrophil lipocalin in body fluids. (1995) (24)
ADAM15 decreases integrin alphavbeta3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion. (2005) (24)
A 1H nuclear-magnetic-resonance study of the solution conformation of the isoinhibitor K from Helix pomatia. (1978) (24)
A Highly Sensitive Immunoenzymometric Assay for the Determination of Angiogenin (1993) (23)
The collagenase inhibitor from human polymorphonuclear leukocytes. Isolation, purification and characterisation. (2005) (23)
Migration of polymorphonuclear leukocytes through human amnion membrane--a scanning electron microscopic study. (1992) (23)
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. (1997) (22)
Broad‐Specificity Protease‐Isoinhibitors for Trypsin, Chymotrypsin, Plasmin and Kallikrein from Snails (Helix pornatia) (1972) (22)
Proteinases in Inflammation and Tumor Invasion (1986) (22)
Kinetics of the interaction of alpha-chymotrypsin with trypsin kallikrein inhibitor (Kunitz) in which the reactive-site peptide bond Lys-15--Ala-16 is split. (1978) (22)
Isolation and characterization of an oligosaccharide- and glycoprotein-specific sialidase from human leucocytes. (1984) (21)
Transforming growth factor beta 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes. (1994) (21)
A new inhibitor of elastase from the sea anemone (Anemonia sulcata). (1987) (20)
Angiogenin: A Novel Inhibitor of Neutrophil Lactoferrin Release during Extracorporeal Circulation (2003) (19)
Separation of granule subpopulations in human polymorphonuclear leukocytes. (1990) (18)
Strong crossreaction of human anti-aprotinin antibodies from heart transplant patient with [Arg15]aprotinin. (1997) (17)
Kinetics of inhibition of human plasma kallikrein by a site-specific modified inhibitor Arg15-aprotinin: evaluation using a microplate system and comparison with other proteases. (1987) (17)
The metal ion requirement for activation of latent collagenase from human polymorphonuclear leucocytes. (1981) (17)
[Proteinase isoinhibitors with broad specificity for trypsin, chymotrypsin, plasmin and kallikrein from cuttlefish (Loligo vulgaris)]. (1973) (16)
Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors (1976) (16)
On the Teratogenesis of Round‐Headed Spermatozoa: Investigations with Antibodies Against Acrosin, an Intraacrosomally Located Acrosin‐Inhibitor, and the Outer Acrosomal Membrane (2009) (15)
The N-terminus of collagenase MMP-8 determines superactivity and inhibition: a relation of structure and function analyzed by biomolecular interaction analysis. (1999) (15)
Characterisation of beta 1-anticollagenase from human plasma and its reaction with polymorphonuclear leukocyte collagenase by disulfide/thiol interchange. (2005) (15)
The in Vivo Effect of Doxycycline Treatment on Matrix Metalloproteinases in Reactive Arthritis a (1994) (15)
Recombinant aprotinin homologue with new inhibitory specificity for cathepsin G. (1991) (14)
Trypsin-kallikrein isoinhibitor K (type Kunitz) from snails (Helix pomatia). Purification and characterization. (1975) (14)
Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat. (1995) (14)
The primary structure of pig pancreatic kallikrein B. (1976) (14)
ThepH dependence of the equilibrium constantKHyd for the hydrolysis of the Lys15-Ala16 reactive-site peptide bond in bovine pancreatic trypsin inhibitor (aprotinin) (1988) (13)
Occurrence of multiple forms of bull and ram acrosin during proenzyme activation and inhibition of activation by p-nitrophenyl p'-guanidinobenzoate. (1976) (13)
[Human acrosin: inhibition by protein-proteinase inhibitors]. (1972) (13)
Semisynthesis of Arg15, Glu15, Met15, and Nle15-aprotinin involving enzymatic peptide bond resynthesis (1989) (13)
Regeneration of native structure and biological activity by air oxidation of reduced pancreatic secretory trypsin inhibitor and Des‐Thr‐Ser‐Pro‐Gln‐Arg‐inhibitor (1970) (13)
1H NMR studies at 360 Mhz of the methyl groups in native and chemically modified basic pancreatic trypsin inhibitor (BPTI) (1977) (13)
BPTI backbone variants and implications for inhibitory activity. (2009) (13)
Submicro-determination of amino acids by a single-column analysis in a 4-hour run using automated buffer gradient mixing. (1973) (12)
Partial amino-acid sequence of human PMN leukocyte procollagenase. (1990) (12)
Leukodiapedesis, release of PMN leukocyte proteinases and activation of PMNL procollagenase. (1991) (11)
Computational study of the catalytic domain of human neutrophil collagenase. Specific role of the S3and S′3subsites in the interaction with a phosphonate inhibitor (2002) (11)
Cloning, expression and activation of a truncated 92-kDa gelatinase minienzyme. (1997) (11)
Reactive Site Cleavage, Thermodynamic Control Resynthesis, and Properties of Chemically Derivatized Trypsin-Kallikrein-Inhibitors (1974) (11)
[Measuring the concentration of various plasma and placenta extract proteolytic and vascular factors in pregnant patients with HELLP syndrome, pre-/eclampsia and highly pathologic Doppler flow values]. (1995) (11)
Matrix metalloproteinases (MMP-8, -13, and -14) interact with the clotting system and degrade fibrinogen and factor XII (Hagemann factor). (2000) (11)
Purification, Characterization, and Structural Studies of Proteinase Inhibitors from Boar Seminal Plasma and Boar Spermatozoa (1974) (11)
Leukocyte Proteinase Release During Storage of Red Cell Concentrates (1994) (10)
Formation of a covalent Hg‐Cys‐bond during mercurial activation of PMNL procollagenase gives evidence of a cysteine‐switch mechanism (1992) (10)
Structural characterization by nuclear magnetic resonance of a reactive-site 13carbon-labelled basic pancreatic trypsin inhibitor with the peptide bond Arg-39--Ala-40 cleaved and Arg-39 removed. (1979) (10)
Determination of arginine in the reactive site of proteinase inhibitors by selective and reversible derivatization of the arginine side chain. (1976) (10)
Aminopeptidases from human leucocytes. (1984) (10)
Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis. (2004) (10)
Inactivation of human plasma alpha 1-proteinase inhibitor by human PMN leucocyte collagenase. (1990) (10)
Combination treatment in Chlamydia-triggered reactive arthritis: comment on the article by Carter et al. (2011) (10)
[7] Car☐ypeptidase C (1977) (10)
Intra‐acrosomally located acrosin‐inhibitors: Evolution and developmental patterns in mammals (1984) (9)
Recombinant Cryptic Human Fibronectinase Cleaves Actin and Myosin: Substrate Specificity and Possible Role in Muscular Dystrophy (2001) (9)
Mass Spectral Determination of Peptide Bond Hydrolysis Equilibria in Protein Proteinase-Inhibitors (1971) (9)
The effect of cleaving the reactive-site peptide bond Lys-15--Ala-16 on the conformation of bovine trypsin-kallikrein inhibitor (K unitz) as revealed by solvent-perturbation spectra, circular dichroism and fluorescence. (1975) (9)
8 – Reversible Inhibitors of Serine Proteinases: Naturally Occurring Miniproteins, Semisynthetic Variants, Recombinant Homologs, and Synthetic Peptides (1995) (9)
Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris. (2000) (9)
Direct Microsequencing of Blotted and Covalently Attached Proteins in a Cross-Flow Reaction Chamber (1991) (9)
Characterization and sequence determination of six aprotinin homologues from bovine lungs. (1988) (9)
Characterisation of a novel matrix metalloproteinase inhibitor on pancreatic adenocarcinoma cells in vitro and in an orthotopic pancreatic cancer model in vivo. (2008) (8)
Amino acid micro determination with a standard single-column analyzer. (1969) (8)
Matrix degrading proteinases from human granulocytes: type I, II, III collagenase, gelatinase and type IV, V-collagenase. A survey of recent findings and inhibition by gamma-anticollagenase. (1986) (8)
THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS (1993) (8)
Activation of the human leukocyte proteinases elastase and cathepsin G by various surfactants. (1990) (8)
Placebo‐Controlled Study of the Effects of Three‐Month Lymecycline Treatment on Serum Matrix Metalloproteinases in Reactive Arthritis a (1994) (8)
Kinetics of Binding of Bovine Trypsin‐Kallikrein Inhibitor (Kunitz) in which the Reactive‐Site Peptide Bond Lys‐15‐Ala‐16 is Cleaved, to α‐Chymotrypsin and β‐Trypsin (1975) (8)
Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases. (2002) (8)
Inhibition of Tryptase TL2 from Human T4+ Lymphocytes and Inhibition of HIV-1 Replication in H9 Cells by Recombinant Aprotinin and Bikunin Homologues (1997) (8)
IMMUNOLOGICAL CHARACTERIZATION OF NATURAL AND SEMISYNTHETIC APROTININ VARIANTS (1989) (7)
On the carbohydrate composition of bovine colostrum trypsin inhibitor. (1975) (7)
Kinetic Analysis of the Binding of Hemopexin-Like Domain of Gelatinase B Cloned and Expressed in Pichia pastoris to Tissue Inhibitor of Metalloproteinases-1 (2003) (7)
Partial amino acid sequence of human PMN leukocyte procollagenase. (1990) (7)
Effect of immunosuppressive drugs on the release of metalloproteinases from human polymorphonuclear leukocytes (1991) (7)
Pyroglutamyl-aprotinin, a new aprotinin homologue from bovine lungs--isolation, properties, sequence analysis and characterization using 1H nuclear magnetic resonance in solution. (1987) (7)
Inhibition of Matrix Metalloproteinases in Rheumatoid Arthritis and the Crystallographic Binding Mode of a Peptide Inhibitor (1994) (6)
New nitroxide reagents for the selective spin-labelling at the guanidino moiety of arginine residues in peptides and proteins (1987) (6)
[Trypsin inhibitors. VII. Primary structure of the specific trypsin inhibitor II (Kazal-type) from porcine pancreas. Sequence analysis with mass spectrometry identification of the p-bromophenylthio-hydantoins from the Edman degradation]. (1970) (6)
Mass spectral identification and quantification of phenylthiohydantoin derivatives from Edman degradation of proteins: Cysteine derivatives (1972) (6)
Amino Acid Sequence of Snail Inhibitor K and Correlation of Structure and Specificity (1974) (6)
Synthesis and reduction of endothiodipeptides containing malonic acid derivatives (1999) (6)
Cleavage of peptide-4-nitroanilide substrates with varying chain length by human leukocyte elastase. (1981) (6)
Temporary Inhibition— A Result of Consecutive Peptide Bond Hydrolysis (1974) (6)
Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19. (2004) (6)
Studies on Structure and Activity of Pancreatic Secretory Trypsin Inhibitors from Pig, Sheep, Dog and Cat (1971) (5)
Leukodiapedesis, function, and physiological role of leucocyte matrix metalloproteinases. (1997) (5)
Cathepsin D from human leukocytes. Purification by affinity chromatography and properties of the enzyme. (1988) (5)
3 Membrane protein folding in detergents (2011) (4)
Reversible Inhibitors of Serine Proteinases (1995) (4)
Enzymatic resynthesis of the "reactive site" bond in the modified aprotinin derivatives [seco-15/16]aprotinin and [Di-seco-15/16,39/40]aprotinin. (1988) (4)
[New polyvalent protease inhibitors for trypsin, chymotrypsin, plasmin and kallikreins from snails (Helix pomatia)]. (1972) (4)
Identification of the active site of gelatinase B as the structural element sufficient for converting a protein to a metalloprotease. (2002) (4)
Complex formation of guanidinated bovine trypsin inhibitor (Kunitz) with trypsin, chymotrypsin and trypsinogen as studied by the spin‐label technique (1982) (4)
Bimolecular interaction of matrix metalloproteinases and their inhibitors TIMPs. (1998) (4)
Isolation of porcine urinary kallikrein. (1976) (4)
The specific trypsin inhibitor from pig pancreas. (1969) (3)
Antimetastatic efficacy of WX-UK1 in a resected, spontaneously metastasizing rat mammary tumor model (2002) (3)
The Carbohydrate Linkage Site of Cow Colostrum Trypsin Inhibitor (1978) (3)
Structure and function of natural proteinase inhibitors. (1973) (3)
Activation of chymotrypsinogen by boar acrosin and its prevention by antiboar acrosin rabbit gamma-globulins. (1976) (3)
Proteolytic Enzyme Inhibitors (1981) (3)
3D STRUCTURE AND DRUG DESIGN (2002) (3)
[The disulfide bridges of the trypsin-kallikrein inhibitor K from snails (Helix pomatia). Thermal inactivation and proteolysis by thermolysin (author's transl)]. (1976) (3)
[67] Trypsin-kallikrein inhibitors from snails (Helix pomatia) (1976) (3)
The degradation of collagen by a metalloproteinase from human leucocytes. (1988) (3)
Granulocyte Chemotaxis Measured in a Boyden Chamber Assay by Quantification of Neutrophil Elastase (1993) (3)
Methods in Protein Sequence Analysis, H. Jörnvall, J.-O. Höög, A.-M. Gustavsson (Eds.). Birkhäuser Verlag AG,, Basel (1991), 408 pp. (ISBN 3-7643-2506-2). Price: 98, - sFr./118,- DM (1992) (3)
Leukodiapedesis, compartmentalisation and secretion of PMN leukocyte proteinases, and activation of PMN leukocyte procollagenase. (1991) (3)
Novel heterocyclic inhibitors of matrix metalloproteinases: three 6H-1,3,4-thiadiazines. (2001) (3)
Aprotinin derivatives with chromophoric leaving groups can be used as highly selective active-site titrants for serine proteinases and permit the determination of kinetic constants of enzyme-inhibitor complexes. (1988) (3)
An Insulin Degrading Proteinase from Human Erythrocytes and Its Inhibition by Proteinase Inhibitors (1974) (3)
Proceedings of the International Research Conference on Proteinase Inhibitors, Munich, November 4-6, 1970 (1971) (3)
[Identification of organs of snails (Helix pomatia) synthetizing protease inhibitors]. (1972) (3)
MPSA short communications (1988) (3)
Enzymatic fragment substitution as a tool in protein design. (1991) (3)
Structure and function of natural inhibitors as antagonists of proteinase activities. (1984) (2)
[69] Trypsin-kallikrein inhibitors from cuttlefish (Loligo vuglaris) (1976) (2)
Modern methods in protein- and nucleic acid research : review articles (1990) (2)
The Chemical Structure of Biologically Important Macromolecules (1983) (2)
The activation of human neutrophil gelatinase. (1990) (2)
1 Three-phase partitioning (2011) (2)
[Trypsin inhibitors. V. Isolation of a des-thr-ser-pro-gln-arg-trypsin inhibitor with full biological activity from the pig]. (1969) (2)
Quantitative mass spectral identification of p-bromophenylthiohydantoins from Edman degradations by tetradeuterated internal standards. (1976) (2)
Gas chromatographic identification of the thiohydantoins of degradation products of peptides and proteins. (1970) (1)
Short sequence-paper Pregnancy-associated plasma protein-E (PAPP-E) 1 (2000) (1)
12 Chemical modifi cation of proteins in living cells (2011) (1)
Semisynthetic aprotinin derivatives with specific alterations at the reactive-site peptide bond can be used to study structure-function relationships. (1989) (1)
ID: 108 HIGH MMP-9/NGAL COMPLEX LEVELS IN GASTRIC CANCER TISSUE ARE ASSOCIATED WITH WORSE SURVIVAL (2006) (1)
Trypsin-kallikrein inhibitors from snails (Helix pomatia). (1976) (1)
NON-RADIOACTIVE PLAQUE AND COLONY SCREENING WITH DIGOXIGENIN- 11-dUTP TAILED OLIGONUCLEOTIDES (1990) (1)
HUMAN TUMOR-ASSOCIATED TRYPSIN(OGEN)-2 ACTIVATES 3 GENETICALLY DISTINCT BUT STRUCTURALLY HOMOLOGOUS HUMAN PRO-MATRIX METALLOPROTEINASES (1994) (1)
Peptide/protein inhibitors of trypsin and kallikrein - primary structural requirements. (1983) (1)
Human Latent PMN Leukocyte Collagenase and Regulation of Activity via Disulfide-Thiol Interchange as Catalyzed by the Glutathione Cycle (1981) (1)
The amino-acid sequence of isoinhibitor K form snails (Helix pomatia). A sequence determination by automated Edman degradation and mass-spectral identification of the phenylthiohydantoins. (1975) (1)
Semisynthetic arginine-15-aprotinin, an improved inhibitor for human plasma kallikrein. (1989) (1)
[68] Albumin gland inhibitor from snails (Helix pomatia) (1976) (1)
Biological functions of proteinases : 30. Colloquium der Gesellschaft für Biologische Chemie, 26.-28. April 1979 in Mosbach/Baden (1979) (1)
[Characterization of a trypsin-like proteinase (acrosin) from boar spermatozoa by inhibition with different protein proteinase inhibitors. 3. Inhibitors from pancreas glands]. (1972) (1)
Novel Heterocyclic Inhibitors of Matrix Metalloproteinases: Three 6H-1,3,4-thiadiazines (2001) (1)
Carboxypeptidase C. (1977) (1)
10 Wide-angle X-ray solution scattering (WAXS) (2011) (1)
Trypsin-kallikrein inhibitors from cuttlefish (Loligo vulgaris). (1976) (1)
Water Contents and Quality Criteria of Microsequencing Chemicals. Preliminary Results of a Reevaluation (1986) (1)
126 – Neutrophil collagenase (2004) (1)
Influence of boar acrosin antibodies produced in rabbit and sheep on chymotrypsinogen activation catalyzed by acrosin from boar, bull, ram, rabbkt and human. (1976) (1)
CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX (1999) (1)
On the Mechanism of Temporary Inhibition (1971) (1)
Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium (1980) (1)
COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) (1996) (1)
Function and Structure of Human Leucocyte Collagenase (1995) (1)
Semisynthetic inhibitors of human leukocyte elastase and their protective effect on lung elastin degradation in vitro. (1988) (1)
[Isolation and purification of the pancreatic secretory trypsin inhibitor of the cat]. (1971) (1)
Quantification of hemostatic proteins and activation products in synovial fluids from arthritic joints prior to and after induction of chemical synoviorthesis. (1996) (1)
COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) (1996) (0)
Broad-specificity protease-isoinhibitors for trypsin, chymotrypsin, plasmin and kallikrein from snails (Helix pomatia). Isolation, inhibition characteristics and amino-acid composition. (1972) (0)
Kinetics of binding of bovine trypsin-killikrein inhibitor (K unitz) in which the reactive-site peptide bond Lys-15--Ala-16 is cleaved, to alpha-chymotrypsin and beta-trypsin. (1975) (0)
HUMAN NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (HNGAL), REGULARISED AVERAGE NMR STRUCTURE (1999) (0)
Some properties of latent collagenase from human synovial fluid. (1990) (0)
Spin-Labelled Amino Acids, Peptides and Proteins - Synthesis and Application (1983) (0)
Contents, Vol. 35, Supplement 1, 1995 (1995) (0)
INHIBITION OF RHEUMATOID CARTILAGE DEGRADATION - A BIOMECHANICAL ASSAY FOR POTENTIAL ANTI-RHEUMATIC DRUGS (1982) (0)
Interaction of β1-Anticollagenase from Human Plasma with Collagenases from Various Tissues and Competition with α2-Macroglobulin (2005) (0)
[On trypsin inhibitors. 3. Modification and inhibotory behavior of the specific trypsin inhibitor from porcine pancreas--a tryptic hydrolysis catalyzable in acid]. (1968) (0)
Characterization of Carrier Ampholytes by New Visualization Reactions and Chromatographic Methods (1977) (0)
Chemical shift assignments, 3JHNHA coupling constants and secondary structure of HNGAL (Human Neutrophil Gelatinase-Associated Lipocalin) in its apo form. (2011) (0)
Concentrations of matrix metalloproteinase 8 and 9 and tissue inhibitor of metalloproteinases-1 in the uterus during preterm delivery (2001) (0)
The protein epitope mimetic approach to protein-protein interaction inhibitors (2011) (0)
7 On-membrane identification of gel-resolved proteins by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) (2011) (0)
9 Single-crystal spectroscopy correlated with X-ray crystallography provides complementary perspectives on macromolecular function (2011) (0)
[Trypsin inhibitors. IV. 2 specific trypsin inhibitors from porcine pancreas]. (1969) (0)
Proteinases and Proteinase Inhibitors in Fertilization (1976) (0)
Functional Anatomy of Acrosin Inhibitors (1975) (0)
[On the distribution of proteinase inhibitors of broad specificity in the organs of cuttle fish (Loligo vulgaris) (author's transl)]. (1973) (0)
Modern methods in protein chemistry : review articles/ editor, Harald Tschesch (1983) (0)
Contribution of matrix metalloproteinases to colorectal cancer invasion and metastasis (1998) (0)
Inhibition of Insulin Specific Protease by Proteinase Inhibitors from the Snail (Helix pomatia) (1974) (0)
Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor (2005) (0)
NEUTROPHIL TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES-1 (TIMP-1) OCCURS IN NOVEL VESICLES WHICH DO NOT FUSE WITH THE PHAGOSOME (2000) (0)
Albumin gland inhibitor from snails (Helix pomatia). (1976) (0)
Regulation of matrix metalloproteinases by human tumor-associated trypsin(ogen)-2 (1997) (0)
[Disulfide bridges of the secretory trypsin inhibitor from procine pancreas and the degradation of covalent structure during the temporary inhibition]. (1972) (0)
11 Where purity matters: recombinant versus synthetic peptides in beta amyloid formation (2011) (0)
Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor (2001) (0)
COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) (1996) (0)
[On trypsin inhibitors. II. On the characterization of the specific trypsin inhibitor from porcine pancreas]. (1967) (0)
Pregnancy-associated plasma protein-E ( PAPPE ) 1 (2000) (0)
Table of Contents (1994) (0)
Boar and Human Acrosin and Acrosin Inhibitors (1973) (0)
Primary structure of pig pancreatic kallikrein B (1976) (0)
[2,2,2-Trifluoro-1-(2-ureido-ethanesulfonyl)-N-benzoylethylamine, a reagent for blocking lysine residues in proteins against tryptic hydrolysis]. (1969) (0)
Crystal structure of human MMP-12 (Macrophage Elastase) at true atomic resolution (2001) (0)
CHEMICAL MUTATION BY AMINO ACID EXCHANGE IN THE REACTIVE CENTER OF A PROTEINASE INHIBITOR AND ALTERATION OF ITS INHIBITING SPECIFICITY (1981) (0)
COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) (2001) (0)
[On modification of the specific trypsin inhibitor from porcine pancreas during inhibition by trypsin]. (1967) (0)
AS ANTAGONISTS OF PROTEINASE ACTIVITIES (1984) (0)
6 Protein import into the intermembrane space of mitochondria (2011) (0)
Proteinase Inhibitor Engineering by Chemical and Enzymic Semisynthesis (1995) (0)
FUNCTION AND STRUCTURE OF HUMAN PLASMA α1-ANTITRYPSIN (1978) (0)
Interaction of beta 1-anticollagenase from human plasma with collagenases from various tissues and competition with alpha 2-macroglobulin. (1983) (0)
Collagenase in S jogren ' s syndrome (2004) (0)
[Properties of the trypsin-like (acrosin) from boar spermatozoa]. (1972) (0)
4 Glycoprotein-folding quality control in the endoplasmic reticulum (2011) (0)
Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer) (2006) (0)
British Connective Tissue Society Meeting (2007) (0)
2 Folding and degradation functions of molecular chaperones (2011) (0)
Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements (1995) (0)
14 Proteomic analysis of Duchenne muscular dystrophy (DMD) (2011) (0)
COMPLEX OF PRO-LEU-L-TRP PHOSPHONATE WITH THE CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) (2001) (0)
8 Analysis of protein complexes using chemical cross-linking and mass spectrometry (2011) (0)
5 Conformational dynamics in peptides and proteins studied by triplet-triplet energy transfer (2011) (0)
Isolation of porcine urinary kallikrein (1976) (0)
Editor. List of contributing authors (2011) (0)
SEMISYNTHESIS OF ARG-15-APROTININ, GLU-15-APROTININ, MET-15-APROTININ, AND NLE15-APROTININ INVOLVING ENZYMATIC PEPTIDE-BOND RESYNTHESIS (1989) (0)
Book Review: Matrix Metalloproteinase Protocols Edited by Ian M.Clark (2003) (0)
Spin-label studies on protein proteinase inhibitors: Complex formation and conformational changes of the bovine trypsin inhibitor (Kunitz) (1981) (0)
Proteinases in inflammation and tumor invasion : review articles including those from an international conference, Bielefeld, Federal Republic of Germany, March 14-16, 1985 (1986) (0)
Mode of binding of R- and S- sunlphonamide phosphonate inhibitors in the active site of MMP-8 (2005) (0)
Chapter 153 – Neutrophil Collagenase (2013) (0)
Design of an aprotinin variant with inhibitory activity against chymotrypsin and cathepsin G by recombinant DNA technology. (1990) (0)

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