Harry Victor Gelboin

Harry Victor Gelboin's AcademicInfluence.com Rankings

Biology

#3766

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#5713

Historical Rank

Molecular Biology

#257

World Rank

#261

Historical Rank

Biochemistry

#369

World Rank

#442

Historical Rank

biology Degrees

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Biology

Harry Victor Gelboin's Degrees

PhD Biochemistry University of Chicago
Bachelors Chemistry University of Chicago

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Harry Victor Gelboin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. (1968) (1534)
Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. (1980) (1075)
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism (1988) (714)
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. (1992) (594)
Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. (1994) (518)
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. (1989) (461)
The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. (1969) (412)
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. (1986) (403)
Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in microsomes from rat tissues: differential inhibition and stimulation by benzoflavones and organic solvents. (1971) (363)
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site. (1994) (356)
Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. (1993) (345)
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. (1991) (334)
A microsome-dependent binding of benzo[a]pyrene to DNA. (1969) (332)
Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. (1989) (279)
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. (1990) (254)
Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene. (1976) (246)
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. (1991) (241)
The induction of a specific form of cytochrome P-450 (P-450j) by fasting. (1987) (227)
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction. (1968) (210)
Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat. (1987) (209)
Targeted Disruption of the Microsomal Epoxide Hydrolase Gene (1999) (202)
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. (1988) (199)
Further characterization of the expression in liver and catalytic activity of CYP2B6. (1998) (191)
Benzo[a]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography (1974) (190)
Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450. (1986) (190)
Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver. (1998) (188)
Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase (1969) (184)
THE STIMULATORY EFFECT OF 3-METHYLCHOLANTHRENE ON BENZPYRENE HYDROXYLASE ACTIVITY IN SEVERAL RAT TISSUES: INHIBITION BY ACTINOMYCIN D AND PUROMYCIN. (1964) (184)
Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women. (1969) (180)
Carcinogens, enzyme induction, and gene action. (1967) (180)
High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane. (1974) (175)
Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450. (1982) (168)
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. (1989) (166)
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. (1988) (160)
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. (1988) (157)
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. (2000) (153)
Enzymatic conjugation of benzo (a) pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid. (1976) (152)
Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene (1972) (149)
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. (1991) (149)
The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3. (1991) (147)
A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. (1991) (144)
Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats. (1988) (144)
K-region and non-K-region metabolism of benzo(a)pyrene by rat liver microsomes. (1973) (142)
Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients (1991) (141)
Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450 (2000) (140)
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. (1987) (140)
Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status. Distinction of two types by 7,8-benzoflavone. (1975) (140)
Enzymatic hydroxylation of benzopyrene and its relationship to cytotoxicity. (1969) (138)
DNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment. (1991) (137)
Dimethylbenzanthracene Tumorigenesis and Aryl Hydrocarbon Hydroxylase in Mouse Skin: Inhibition by 7,8-Benzoflavone (1970) (137)
The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation. (1988) (135)
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s. (1990) (134)
Specificity and cross-reactivity of monoclonal and polyclonal antibodies against cytochrome P-450E of the marine fish scup. (1987) (132)
Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation. (1993) (130)
Kinetic analysis of the metabolism of benzo(a)pyrene to phenols, dihydrodiols, and quinones by high-pressure chromatography compared to analysis by aryl hydrocarbon hydroxylase assay, and the effect of enzyme induction. (1975) (130)
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. (1994) (125)
Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates. (1977) (125)
Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines. (1987) (123)
Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estrone. (1997) (121)
Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. (1989) (117)
Microsomal hydroxylases: induction and role in polycyclic hydrocarbon carcinogenesis and toxicity. (1972) (117)
Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding. (1972) (112)
Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids. (1994) (109)
The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. (1989) (105)
beta-Glucuronidase catalyzed hydrolysis of benzo(a)pyrene-3-glucuronide and binding to DNA. (1978) (105)
Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450. (1984) (104)
Carcinogenesis : fundamental mechanisms and environmental effects (1980) (103)
A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver. (1992) (103)
The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. (1986) (102)
Metabolic activation of benzo(a)pyrene and binding to DNA in cultured human bronchus. (1977) (100)
Enzymatic mechanism of benzo[a]pyrene conversion to phenols and diols and an improved high-pressure liquid chromatographic separation of benzo[a]pyrene derivatives. (1977) (100)
The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. (1990) (96)
Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha. (1990) (96)
Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. (1994) (96)
Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase. (1996) (95)
Rapid and Marked Inhibition of Rat-Liver RNA Polymerase by Aflatoxin B1 (1966) (94)
Effects of 3-Methylcholanthrene and Phenobarbital on Amino Acid Incorporation into Protein (1961) (93)
Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene. (1987) (92)
Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7. (1989) (91)
Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies. (1982) (90)
The role of aryl hydrocarbon hydroxylase in 7,12-dimethylbenz(a)anthracene skin tumorigenesis: on the mechanism of 7,8-benzoflavone inhibition of tumorigenesis. (1972) (89)
Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA. (1978) (87)
K region benzo(α)pyrene-4,5-oxide is conjugated by homogeneous gluthathione S-transferases (1975) (84)
Immunohistochemical localization of cytochrome P-450 in rat brain (1987) (83)
Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus. (1989) (81)
Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2. (1996) (79)
Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity (2005) (79)
Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA. (1986) (78)
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism. (1991) (78)
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity (1989) (77)
The role of ribonucleic acid and protein synthesis in microsomal aryl hydrocarbon hydroxylase induction in cell culture. The independence of transcription and translation. (1970) (77)
Expression of mammalian cytochrome P450 using vaccinia virus. (1991) (76)
In vitro metabolism of benzo(a)pyrene by human liver microsomes and lymphocytes. (1975) (76)
Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver. (1991) (74)
Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes. (1993) (72)
Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. (1989) (72)
Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital. (1984) (71)
Comparison of benzo(a)pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene metabolism in human blood monocytes and lymphocytes. (1979) (70)
High-pressure liquid chromatographic separation of 10 benzo(a)pyrene phenols and the identification of 1-phenol and 7-phenol as new metabolites. (1976) (70)
Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro (2004) (70)
Mutagen activation by cDNA‐expressed P1450, P3450, and P450a (1989) (69)
Monoclonal antibody-directed characterization of benzene, ethoxyresorufin and pentoxyresorufin metabolism in rat liver microsomes. (1990) (69)
Position-specific oxygenation of benzo(a)pyrene by different forms of purified cytochrome P-450 from rabbit liver. (1975) (68)
Polyinosinic-Polycytidylic Acid Inhibits Chemically Induced Tumorigenesis in Mouse Skin (1970) (67)
STUDIES ON THE MECHANISM OF ARYL HYDROCARBON HYDROXYLASE INDUCTION AND ITS ROLE IN CYTOTOXICITY AND TUMORIGENICITY (1971) (67)
Studies on soluble ribonucleic acid of rabbit liver. II. Preparation and properties of rabbit-liver soluble RNA. (1962) (67)
Metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured human bronchus and pancreatic duct. (1977) (67)
Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes. (1996) (66)
Aryl hydrocarbon (benzo ( ) pyrene) hydroxylase: inducible in extrahepatic tissues of mouse strains not inducible in liver. (1973) (66)
Human cytochromes P450: evolution and cDNA-directed expression. (1992) (65)
Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system. (1990) (64)
Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4'5-epoxide as a metobolite of benzoapyrene. (1975) (64)
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450. (1990) (63)
Cytochrome P450 and monoclonal antibodies. (1993) (63)
A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E). (1987) (63)
Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes. (1985) (63)
Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. (1992) (62)
Interindividual and intraindividual variations in aryl hydrocarbon hydroxylase in monocytes from monozygotic and dizygotic twins. (1977) (62)
Differences in benzo(a)pyrene metabolism between rodent liver microsomes and embryonic cells. (1976) (62)
Studies on the mechanism of drug-induced microsomal enzyme activities. V. Phenobarbital stimulation of endogenous messenger RNA and polyuridylic acid-directed L-[14C]-phenylalanine incorporation. (1966) (62)
Interactions among cytochromes P-450 in the endoplasmic reticulum. Detection of chemically cross-linked complexes with monoclonal antibodies. (1991) (61)
Retention of membrane proteins by the endoplasmic reticulum (1985) (61)
Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis. (1994) (61)
cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. (1987) (60)
Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450. (1994) (60)
Carcinogens, drugs, and cytochromes P-450. (1983) (60)
Expression of mammalian cytochrome P450 using baculovirus. (1991) (60)
Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase. (1988) (60)
The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives (1996) (58)
Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations. (1987) (58)
3-Methylcholanthrene and Phenobarbital Stimulation of Rat Liver RNA Polymerase (1967) (58)
Enhancement of Cardiac L-Type Ca2+ Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2 (2004) (58)
10 – Benzo[a]pyrene Metabolism: Activation and Detoxification (1978) (58)
Inhibitory monoclonal antibody to human cytochrome P450 2B6. (1998) (57)
THE STIMULATORY EFFECT OF 3-METHYLCHOLANTHRENE ON MICROSOMAL AMINO ACID INCORPORATION AND BENZPYRENE HYDROXYLASE ACTIVITY AND ITS INHIBITION BY ACTINOMYCIN D. (1963) (57)
Monoclonal antibodies for studies on xenobiotic and endobiotic metabolism. Cytochromes P-450 as paradigm. (1985) (57)
Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6. (1993) (57)
Genetic and environmental factors in experimental and human cancer (1980) (56)
Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. (1997) (56)
Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4. (1995) (55)
Enzymatic conversion of benzo(a)pyrene phenols, dihydrodiols and quinones to sulfate conjugates. (1977) (55)
Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human peripheral blood monocytes (1974) (54)
Microsome-specific stimulation by phenobarbital of amino acid incorporation in vivo. (1965) (54)
STUDIES ON THE MECHANISM OF METHYLCHOLANTHRENE INDUCTION OF ENZYME ACTIVITIES. II. STIMULATION OF MICROSOMAL AND RIBOSOMAL AMINO ACID INCORPORATION: THE EFFECTS OF POLYURIDYLIC ACID AND ACTINOMYCIN-D. (1964) (54)
Assay and properties of glutathione-S-benzo(a)pyrene-4,5-oxide transferase. (1975) (54)
Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells. (1987) (53)
Thyroxine stimulation of amino acid incorporation into protein. Localization of stimulated step. (1963) (53)
Stable expression of human cytochrome P450IA2 cDNA in a human lymphoblastoid cell line: Role of the enzyme in the metabolic activation of aflatoxin B1 (1990) (53)
Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens. (1994) (53)
Nonenzymatic reduction of benzo(a)pyrene diol-epoxides to trihydroxypentahydrobenzo(a)pyrenes by reduced nicotinamide adenine dinucleotide phosphate. (1976) (53)
Development of an assay for aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human peripheral blood monocytes. (1976) (53)
A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology. (2003) (52)
Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. (1999) (52)
Inhibition by actinomycin D of DNA synthesis and skin tumorigenesis induced by 7,12-dimethylbenz(a)anthracene. (1968) (52)
Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam. (1998) (51)
Cytochrome P3-450 cDNA encodes aflatoxin B1-4-hydroxylase. (1988) (51)
Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, beta-naphthoflavone and phenobarbital treated rats. (1982) (50)
Aryl hydrocarbon (benzo[a]pyrene) hydroxylase: a mixed-function oxygenase in mouse skin. (1975) (49)
Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat. (1995) (49)
CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. (1994) (49)
Comparison of the formation of benzo[a]pyrene diolepoxide-DNA adducts in vitro by rat and human microsomes: evidence for the involvement of P-450IA1 and P-450IA2. (1989) (49)
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. (1991) (48)
Role of human cytochrome P-450s in risk assessment and susceptibility to environmentally based disease. (1993) (48)
The effects of two isomeric benzoflavones on aryl hydrocarbon hydroxylase and the toxicity and carcinogenicity of polycyclic hydrocarbons. (1972) (48)
Monoclonal antibody phenotyping of interindividual differences in cytochrome P-450-dependent reactions of single and twin human placenta. (1984) (48)
Inhibition of mouse skin tumorigenesis by actinomycin D. (1965) (48)
Studies on hepatic protein-bound dye formation in rats given single large doses of 3'methyl-4-dimethylaminoazobenzene. (1958) (48)
Role of cytochrome P450 IA2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies. (1991) (48)
Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice. (1994) (48)
Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450. (1996) (47)
Detection and purification of cytochromes P-450 in animal tissues with monoclonal antibodies. (1984) (47)
Evidence for a 2,3-epoxide as an intermediate in the microsomal metabolism of benzo[a]pyrene to 3-hydroxybenzo[a]pyrene. (1977) (46)
4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. (2002) (46)
Resolution of optical isomers by high-pressure liquid chromatography. The separation of benzo[a]pyrene trans-diol derivatives. (1977) (45)
Microsomal mixed-function oxidases and epoxide hydratase convert benzo(a)pyrene stereospecifically to optically active dihydroxydihydrobenzo(a)pyrenes. (1976) (45)
Nicotine metabolism by cDNA-expressed human cytochrome P-450s (1992) (45)
Monoclonal antibodies to ethanol induced cytochrome P-450 that inhibit aniline and nitrosamine metabolism. (1986) (44)
Immunochemical characterization of cytochrome P-450 isozymes responsible for benzene oxidation in the rat liver. (1989) (44)
Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolism. (2000) (43)
Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2. (1993) (42)
Monoclonal antibody-directed phenotyping of cytochrome P-450-dependent aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase in mammalian tissues. (1984) (42)
Effect of cytochrome P450 induction on the metabolism and toxicity of ochratoxin A. (1996) (42)
Separation of ten benzo(a)pyrene phenols by recycle high pressure liquid chromatography and identification of four phenols as metabolites. (1976) (42)
Metabolism of benzo(a)pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene by rat liver nuclei and microsomes. (1978) (42)
Aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction in rat liver cells in culture. (1974) (41)
Stereochemistry of the hydrolysis products and their acetonides of two stereoisomeric benzo[a]pyrene 7,8-diol 9,10-epoxides. (1977) (41)
Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse. (1998) (40)
Regenerative changes in hepatic morphology and enhanced expression of CYP2B10 and CYP3A during daily administration of cocaine (1996) (40)
Benzpyrene Hydroxylase Induction by Polycyclic Hydrocarbons in Hamster Embryonic Cells Grown in vitro (1967) (40)
Preparation and characterization of monoclonal antibodies to pregnenolone 16-α-carbonitrile inducible rat liver cytochrome P-450☆ (1986) (39)
Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase. (1992) (39)
Transformation of normal hamster cells by benzo(a)pyrene diol‐epoxide (1977) (39)
Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1. (1991) (39)
Genetic variability in responses to chemical exposure (1984) (38)
Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery. (1999) (38)
Bioactivation of 8-methoxypsoralen and irreversible inactivation of cytochrome P-450 in mouse liver microsomes: modification by monoclonal antibodies, inhibition of drug metabolism and distribution of covalent adducts. (1990) (37)
Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration. (1991) (37)
Cancer susceptibility and carcinogen metabolism. (1977) (37)
Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital. (1988) (37)
The metabolism of 1-nitropyrene by human cytochromes P450. (1990) (37)
Role of cytochrome P450 enzyme induction in the metabolic activation of benzo[c]phenanthrene in human cell lines and mouse epidermis. (1997) (37)
Molecular and cell biology (1978) (37)
Benzo(a)pyrene-4,5-oxide hydratase: assay, properties, and induction. (1975) (36)
Site-directed mutagenesis of cytochrome P450s CYP2A1 and CYP2A2: influence of the distal helix on the kinetics of testosterone hydroxylation. (1992) (36)
Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374. (1995) (36)
Monoclonal antibodies to rabbit liver cytochrome P450 LM2 (1980) (35)
Noncoordinate regulation of the mRNAs encoding cytochromes P-450BNF/MC-B and P-450ISF/BNF-G. (1986) (35)
Characterization of the human cytochrome P450 isozymes responsible for styrene metabolism. (1993) (34)
Microsomal cytochrome P-450 function in fish evaluated with polyclonal and monoclonal antibodies to cytochrome P-450E from scup (Stenotomus chrysops) (1985) (34)
In vitro antioxidative potential of lactoferrin and black tea polyphenols and protective effects in vivo on carcinogen activation, DNA damage, proliferation, invasion, and angiogenesis during experimental oral carcinogenesis. (2008) (33)
Sulfate conjugation of benzo[a]pyrene metabolites and derivatives (1978) (33)
Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1. (1996) (33)
Immunohistochemical detection of human placental cytochrome P-450-associated mono-oxygenase system inducible by maternal cigarette smoking. (1988) (33)
Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism. (1989) (33)
Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19. (2001) (33)
Skin Tumorigenesis by 7,12-Dimethylbenz(a)anthracene: Inhibition by Actinomycin D (1964) (32)
METHYLCHOLANTHRENE-INDUCED CHANGES IN RAT LIVER NUCLEAR RNA. (1964) (32)
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism. (1997) (32)
Monoclonal antibody-directed immunopurification and identification of cytochromes P-450. (1983) (32)
Induction of aryl hydrocarbon (benzo(a)pyrene) hydroxylase in liver cell culture by temporary inhibition of protein synthesis. (1973) (31)
The mechanism of hydrolysis of the non-K-region benzo[a]pyrene diol epoxide r-7, t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene. (1977) (31)
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). (1989) (31)
Cytochromes P-450 in murine lung. An immunohistochemical study with monoclonal antibodies. (1989) (31)
Catalytic activity and stereoselectivity of purified forms of rabbit liver microsomal cytochrome P-450 in the oxygenation of the (-) and (+) enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene. (1979) (30)
STUDIES ON THE MECHANISM OF METHYLCHOLANTHRENE INDUCTION OF ENZYME ACTIVITIES OF RAT LIVER. I. AMINO ACID INCORPORATION IN RAT-LIVER HOMOGENATES. (1964) (30)
Immunohistochemical determination of inducibility phenotype with a monoclonal antibody to a methylcholanthrene-inducible isozyme of cytochrome P-450. (1987) (30)
Assignment of a locus required for flavoprotein-linked monooxygenase expression to human chromosome 2. (1976) (29)
Monoclonal Antibodies and Multifunctional Cytochrome P450: Drug Metabolism as Paradigm (2006) (29)
INDUCTION OF ARYL HYDROCARBON (BENZO[a]PYRENE) HYDROXYLASE AND TYROSINE AMINOTRANSFERASE IN HEPATOMA CELLS IN CULTURE (1974) (29)
Evidence for a PCN-P450 enzyme in chickens and comparison of its development with that of other phenobarbital-inducible forms. (1989) (28)
LACTIC DEHYDROGENASE ISOZYMES IN URINE FROM PATIENTS WITH MALIGNANCIES OF THE URINARY BLADDER. (1965) (27)
Monoclonal antibody-directed radioimmunoassay of specific cytochromes P-450. (1984) (27)
Cytochrome P-450 3A4 (nifedipine oxidase) is responsible for the C-oxidative metabolism of 1-nitropyrene in human liver microsomal samples. (1992) (27)
Mechanisms of Induction of Drug Metabolism Enzymes (1971) (27)
Variation in aryl hydrocarbon (benzo(a)pyrene) hydroxylase activity in heteroploid and predominantly diploid rat liver cells in culture (1976) (26)
Pretreatment with black tea polyphenols modulates xenobiotic-metabolizing enzymes in an experimental oral carcinogenesis model. (2008) (26)
The in vitro formation of protein-bound derivatives of aminoazo dyes by rat liver preparations. (1959) (26)
Characterization of human fetal hepatic cytochrome P-450-associated 7-ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by monoclonal antibodies. (1987) (26)
Metabolism of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-pretreated rats: stimulation and stereochemical effects by induction of cytochromes P450IIE1, P450IIB and P450IA. (1991) (26)
CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification (2004) (26)
Clofibrate-inducible rat hepatic P450s IVAl and IVA3 catalyze the a- and (a-1)-hydroxylation of fatty acids and the w-hydroxylation of prostaglandins El and F2a (1990) (25)
An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver. (1999) (25)
Monoclonal antibodies to rabbit liver cytochrome P-450LM2 and cytochrome P-450LM4. (1982) (24)
Amino-terminal sequence analysis of six cytochrome P-450 isozymes purified by monoclonal antibody directed immunopurification. (1984) (24)
Identification and quantitation of a 2.0-kilobase messenger ribonucleic acid coding for 3-methylcholanthrene-induced cytochrome P-450 using cloned cytochrome P-450 complementary deoxyribonucleic acid. (1982) (24)
Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats. (1987) (24)
Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression. (1991) (24)
Monoclonal antibodies directed characterization of epidermal and hepatic cytochrome P-450 isozymes induced by skin application of therapeutic crude coal tar. (1989) (23)
Analysis of human cytochrome P450 catalytic activities and expression. (1992) (23)
Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver. (1998) (23)
Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome P450 isozymes. (1993) (23)
Regulation of aryl hydrocarbon hydroxylase in intraspecific hybrids of human, mouse, and hamster cells. (1972) (22)
Studies on the removal of endogenous messenger ribonucleic acid activity from rat liver microsomes. Effect of removal on polyuridylic acid-directed incorporation of phenylalanine. (1967) (22)
Cross-reactivity of thirteen monoclonal antibodies with ten vaccinia cDNA expressed rat, mouse and human cytochrome P450s. (1993) (22)
Epidermal cytochrome P-450: immunochemical characterization of isoform induced by topical application of 3-methylcholanthrene to neonatal rat. (1989) (22)
Pyrazole is different from acetone and ethanol as an inducer of the polysubstrate monooxygenase system in mice: evidence that pyrazole-inducible P450Coh is distinct from acetone-inducible P450ac. (1988) (21)
cDNA‐directed expression of rat testosterone 7α‐hydroxylase using the modified vaccinia virus, T7‐RNA‐polymerase system and evidence for 6α‐hydroxylation and Δ6‐testosterone formation (1989) (21)
The time-dependent increase in the binding of benzo[a]pyrene to DNA through (+)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide in primary rat hepatocyte cultures results from induction of cytochrome P450IA1 by benzo[a]pyrene treatment. (1992) (21)
Benzo[a]pyrene Metabolism: Enzymatic and Liquid Chromatographic Analysis and Application to Human Liver, Lymphocytes, and Monocytes (1977) (20)
Activation of promutagens by human cDNA-expressed cytochrome P450s. (1990) (19)
Monoclonal antibody directed detection of cytochrome P-450 (PCN) in human fetal liver. (1988) (19)
Monoclonal antibody characterization of hepatic and extrahepatic cytochrome P-450 activities in rats treated with phenobarbital or methylcholanthrene and fed various cholesterol diets. (1987) (19)
Ribonucleic acid synthesis-dependent induction of aryl hydrocarbon hydroxylase in the absence of ribosomal ribonucleic acid synthesis and transfer. (1972) (19)
Scavenging of hypochlorous acid by lipoic acid (1991) (18)
Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: modification of this effect by specific amino acid substitutions. (1992) (18)
Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. (1985) (18)
Thyroxine stimulation of soluble ribonucleic acid bound amino acid transfer to microsomal protein. (1961) (18)
Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms. (1999) (18)
The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins. (1981) (17)
Genetic toxicology using human cell lines expressing human P-450. (1993) (17)
Stimulation of Ammo-acid Incorporation by Nuclear Ribonucleic Acid from Normal and Methylcholanthrene-treated Rats (1963) (17)
Studies on ethanol-inducible cytochrome P-450 in rabbit liver, lungs and kidneys. (1987) (17)
Multiple cytochromes P-450 are translated from multiple messenger ribonucleic acids. (1983) (17)
Specificity of the in vitro destruction of adrenal and hepatic microsomal steroid hydroxylases by thiosteroids. (1979) (17)
Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats. (2007) (17)
Studies on the metabolism of aminopyrine, antipyrine and theophylline using monoclonal antibodies to cytochrome P-450 isozymes purified from rat liver. (1987) (17)
Hydroxylation of benzo[a]pyrene and binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to deoxyribonucleic acid catalyzed by purified forms of rabbit liver microsomal cytochrome P-450. Effect of 7,8-benzoflavone, butylated hydroxytoluene and ascorbic acid. (1980) (16)
Microsomal aryl hydrocarbon hydroxylases: on their role in polycyclic hydrocarbon carcinogenesis and toxicity and the mechanism of enzyme induction. (1972) (16)
The formation in vitro of protein-bound derivatives of aminoazo dyes by rat liver and its enhancement by benzypyrene pretreatment (1958) (16)
Specificity of the cytochrome P‐450 interaction with cytochromeb 5 (1994) (16)
Carbon tetrachloride-induced loss of microsomal messenger-ribonucleic acid activity. (1967) (16)
Localization of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in mouse lung with monoclonal antibodies. (1986) (16)
Mutagenicity to mammalian cells in culture by (+) and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrenes and the hydrolysis and reduction products of two stereoisomeric benzo(a)pyrene 7,8-diol-9,10-epoxides. (1978) (16)
Developmental regulation of hepatic testosterone hydroxylases: simultaneous activation and repression of constitutively expressed cytochromes P450 in senescent rats. (1990) (15)
Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450. (1980) (15)
Hydroxylation and dealkylation of methyl-n-butylnitrosamine and role of certain cytochrome P-450 isozymes in these reactions. (1993) (15)
N-nitrosopyrrolidine metabolism by cDNA-expressed human cytochrome P-450s (1993) (15)
Metabolism of Benzo[a]pyrene by Seven cDNA Expressed Human Cytochromes P450 (1994) (14)
Inhibitory monoclonal antibodies to human cytochrome P450 2D6. (1997) (14)
Inhibition of 2-acetylaminofluorene oxidations by monoclonal antibodies specific to 3-methylcholanthrene-induced rat liver cytochrome P450. (1983) (14)
Monoclonal antibody-directed analysis of cytochrome P-450-dependent monooxygenases and mutagen activation in the livers of DBA/2 and C57BL/6 mice. (1986) (14)
Persistent effects of a single dose of Aroclor 1254 on cytochromes P450IA1 and IIB1 in mouse lung. (1992) (14)
Concepts in Biochemical Pharmacology (1971) (14)
Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. (1986) (14)
K region benzo (alpha) pyrene-4,5-oxide is conjugated by homogeneous gluthathione S-transferases. (1975) (13)
Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats. (1990) (13)
Aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction in cells in culture. (1979) (13)
Modulation of rat hepatic aryl hydrocarbon hydroxylase by various flavones and polycyclic aromatic hydrocarbons. (1985) (13)
Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1). (1989) (13)
Induction of cytochrome P-450 mRNAs quantitated by in vitro translation and immunoprecipitation. (1984) (13)
The induction of liver microsomal proteins by 3-methylcholanthrene in rats of different age, sex and strain. (1980) (13)
Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver. (1989) (12)
Polycyclic hydrocarbons and cancer (2012) (12)
Immunochemical detection of cytochrome P450 isozymes induced in rat liver byn-hexane, 2-hexanone and acetonyl acetone (2005) (12)
Induction of rat liver microsomal and nuclear cytochrome P-450 by dietary 2-acetylaminofluorene and butylated hydroxytoluene. (1989) (11)
cDNA-directed expression of rat P450s IIA1 and IIA2. Catalytic activities toward steroids and xenobiotics and comparison with the enzymes purified from liver. (1990) (11)
Effects of polycyclic hydrocarbons on ribonucleic acid synthesis in rat liver nuclei and hamster embryo cells. (1972) (11)
Distribution and induction sites of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in murine liver: immunohistochemical localization with monoclonal antibodies. (1988) (10)
(−)Maackiain acetate specifically inhibits different forms of aryl hydrocarbon hydroxylase in rat and man (1981) (10)
The effect of methylcholanthrene, phenobarbital and aflatoxin on RNA polymerase of rat liver. (1967) (10)
Aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase in guinea pig peritoneal macrophages: benz(alpha)anthracene-induced increase of enzyme activity in vivo and in cell culture. (1973) (10)
Monoclonal antibody-directed characterization of rat hepatic P450 catalyzing the ω-1 and ω-2 hydroxylation of prostaglandins (1989) (10)
Involvement of P450 1A1 in benzo(a)pyrene but not in benzo(a)pyrene-7,8-dihydrodiol activation by 3-methylcholanthrene-induced mouse liver microsomes. (1993) (10)
Positional specificity for methyl-n-amylnitrosamine hydroxylation by cytochrome P-450 isozymes determined with monoclonal antibodies. (1991) (10)
Effect of polycyclic hydrocarbons in vitro an aryl hydrocarbon (benzo(a)pyrene) hydroxylase. (1971) (9)
Structural comparison of monoclonal antibody immunopurified pulmonary and hepatic cytochrome P-450 from 3-methylcholanthrene-treated rats. (1986) (9)
Synthetic peptide antigens elicit monoclonal and polyclonal antibodies to cytochrome P450 IA2. (1990) (9)
Epitope-relatedness and phenotyping of hepatic cytochromes P-450 with monoclonal antibodies. (1985) (9)
Phenytoin induction of cytochrome P4502B in mice: effects on hexobarbital hydroxylase activity. (1993) (8)
The electrophoretic distribution of RNA synthesized in vitro by isolated rat liver nuclei. (1970) (8)
The half-life of aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human blood monocytes. (1976) (8)
Isozyme-specific monoclonal antibody-directed assessment of induction of hepatic cytochrome p-450 by clotrimazole. (1989) (8)
Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation. (1989) (8)
DRUGS AND MICROSOMAL ENZYME FORMATION IN VIVO AND IN MAMMALIAN CELL CULTURE (1969) (8)
Contribution of DNA methylation and benzylation to N-nitroso-N-benzyl-methylamine-induced mutagenesis in bacteria: effects of rat liver cytochrome P450 isozymes and glutathione transferases. (1990) (8)
Studies on the mechanism of monoclonal antibody inhibition of enzyme activity of phenobarbital-induced cytochrome P-450. (1990) (8)
Effect of 7 8-benzoflavone on the duration of zoxazolamine paralysis and hexobarbital hypnosis in rats. (1976) (8)
Inhibition of benzo[a]pyrene metabolism by insulin, FITC-insulin and an FITC-insulin-antibody conjugate in the human hepatoma cell line HepG2. (1995) (7)
DNA recombinant and monoclonal antibody directed methods for determining cytochrome P-450 specificity. (1988) (7)
An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys (2000) (7)
Variation in inducibility of cytochrome P-450c and aryl hydrocarbon hydroxylase in rat liver, lung, kidney, pancreas and nasopharynx. (1990) (7)
Mutagenicity of optically pure (--)trans-7,8-dihydroxy-dihydrobenzo[a]pyrene. (1978) (7)
A proteolytically sensitive region common to several rat liver cytochromes P450: effect of cleavage on substrate binding. (1992) (7)
7-Ethoxycoumarin and 7-ethoxyresorufin O-deethylase in human foetal and adult liver: studies with monoclonal antibodies. (1988) (7)
Monoclonal antibodies to cytochromes P450. (1998) (7)
Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase. (1990) (7)
Structure and regulation of the ethanol-inducible cytochrome P450j. (1988) (7)
Use of monoclonal antibodies to characterize the induction response of the cytochrome P-450-dependent mixed function oxidase system to nitrofluoranthenes. (1987) (7)
The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes. (2010) (6)
Catalytic activity of cytochromes P-450 purified by monoclonal antibody-directed immunopurification. (1985) (6)
Specificity of medicarpin and related isoflavonoids in inhibition of rat hepatic mixed function oxidase activity. (1985) (6)
Monoclonal antibodies to rat liver microsomal cytochrome b5. (1992) (6)
7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta. (1992) (6)
THE MECHANISM OF HYDROLYSIS OF THE NON‐K‐REGION BENZO(A)PYRENE DIOL EPOXIDE R‐7,T‐8‐DIHYDROXY‐T‐9,10‐OXY‐7,8,9,10‐TETRAHYDROBENZO(A)PYRENE (1977) (6)
Monoclonal antibody-directed analysis of cytochrome P-450. (1986) (6)
A monoclonal antibody against cytochrome P-450 enhances mutagen activation of N-nitrosodimethylamine by mouse liver S9: studies on the mode of action. (1987) (6)
Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a. (1989) (6)
Use of monoclonal antibodies to cytochrome P450s to indicate the critical dealkylation and the P450s involved in methyl-n-amylnitrosamine mutagenicity in the presence of induced rat liver microsomes. (1995) (6)
Preparation and characterization of monoclonal antibodies to pregnenolone 16-alpha-carbonitrile inducible rat liver cytochrome P-450. (1986) (5)
Genetic regulatory mechanisms and carcinogenesis. (1966) (5)
Cigarette Smoking and Secondary Smoke in Turkey: Effect on Placental Aryl Hydrocarbon Hydroxylase (AHH), Infant Birth Weight, and Size (2002) (5)
Benzo[a]pyrene glucuronide and sulfate conjugate characterization by field desorption mass spectrometry (1982) (5)
Andrew C. Peacock, 1921–1985 (1986) (5)
MECHANISM OF MICROSOMAL ACTIVATION OF BENZO[a] PYRENE TO DIOL-EPOXIDES: THE SEPARATION AND CHARACTERIZATION OF INTERMEDIATES AND PRODUCTS (1977) (5)
Monoclonal antibody-directed determination of cytochrome P-450 types expressed in a human lymphoblastoid cell line. (1985) (5)
Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in guinea pig lymphoid tissue. (1981) (4)
CATALYTIC ACTIVITY AND STEREOSPECIFICITY OF PHENOBARBITAL-INDUCIBLE AND 5,6-BENZOFLAVONE-INDUCIBLE ISOZYMES OF LIVER MICROSOMAL CYTOCHROME P-450 IN THE OXYGENATION OF BENZO[a]-PYRENE AND trans-7,8-DIHYDROXY-7,8-DIHYDROBENZO[a]PYRENE (1980) (4)
Tetrabutylammonium hydroxide: a reagent for the base-catalyzed dehydration of vicinal dihydrodiols of aromatic hydrocarbons. implications to ion-pair chromatography (1981) (4)
Roles of Cytochrome P450 1A1 and 1B1 in Metabolic Activation of Dibenzo[a, l]Pyrene by Microsomes from the Human Mammary Carcinoma Cell Line MCF-7 (2000) (4)
Mapping of cytochrome P-450 distribution and function with monoclonal antibodies and cDNA expression. (1990) (4)
Microsomal hydroxylases: studies on the mechanism of induction and their role in polycyclic-hydrocarbon action. (1971) (4)
STEREOCHEMISTRY OF THE HYDROLYSIS PRODUCTS AND THEIR ACETONIDES OF TWO STEREOISOMERIC BENZO(A)PYRENE 7,8-DIOL 9,10-EPOXIDES (1977) (3)
Preparation of catalytically active cytochromes P-450 by antigen exchange on monoclonal antibody based immunoadsorbents. (1985) (3)
Monoclonal antibody directed isolation and amino-terminal sequence analysis of phenobarbital induced rat liver cytochromes P-450. (1985) (3)
MAMMALIAN ARYL HYDROCARBON HYDROXYLASES IN CELL CULTURES: MECHANISM OF INDUCTION AND ROLE IN CARCINOGENESIS (1974) (3)
Metabolism of fusarin C by rat liver microsomes. Role of esterase and cytochrome P-450 enzymes with respect to the mutagenicity of fusarin C in Salmonella typhimurium. (1989) (3)
Differencesin Benzo(a)pyrene Metabolismbetween Rodent Liver Microsomesand EmbryonicCells (1976) (3)
ASSIGNMENT OF A HUMAN GENE FOR ARYL HYDROCARBON HYDROXYLASE EXPRESSION TO CHROMOSOME 2 (1977) (2)
IMMUNOLOGICAL CROSS-REACTIVITY OF RAT LIVER AND HUMAN CYTOCHROMES P-450 (1980) (2)
The formation in vitro of proteinbound derivatives of aminoazo dyes by rat liver and its enhancement by benzpyrene pretreatment. (1958) (2)
Chairman's summary of session C chirality and cytochrome P-450: a perspective (1988) (2)
Inhibitory monoclonal antibodies and cDNA expression for the characterization of cytochrome P450 function (1990) (2)
23 – Evidence for Linkage between Aryl Hydrocarbon Hydroxylase Expression and Enzyme Markers Assigned to Human Chromosome 2 in Human X Mouse Hybrid Cells (1978) (2)
Studies on the mechanism of microsomal hydroxylase induction and its role in carcinogen action. (1972) (2)
THE APPLICATION OF MONOCLONAL ANTIBODIES FOR STUDIES ON CYTOCHROME P450 (1985) (2)
Sulfate conjugation of benzo[alpha]pyrene metabolites and derivates. (1978) (2)
Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin (2011) (2)
Use of monoclonal antibodies to identify cytochrome P450 isozymes in rat liver microsomes that hydroxylate N-nitrosomethylamylamine at each of six positions. (1991) (1)
Studies on covalent binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to cytochromes P-450 LM2 and LM4 and NADPH-cytochrome P-450 reductase. (1989) (1)
Analysis of microsomal hydroxylase induction in cell culture. (1972) (1)
Monoclonal antibodies to cytochrome P‐450 immunopurify a 45‐kDa protein from a human lymphoblastoid cell line (1985) (1)
On the relationship between transcription, translation, and ribosomal RNA synthesis during microsomal hydroxylase induction. (1973) (1)
Cell-catalyzed binding of 3H-(-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to cellular and exogenous DNA and the role of purified human liver epoxide hydrolase. (1988) (1)
cDNA-directed expression of rat testosterone 7 alpha-hydroxylase using the modified vaccinia virus, T7-RNA-polymerase system and evidence for 6 alpha-hydroxylation and delta 6-testosterone formation. (1989) (1)
Chirality and cytochrome P-450: a perspective. (1988) (1)
Carcinogenesis and gene action. Franz Bielschowsky Memorial Lecture. (1968) (1)
Stable expression of human cytochrome P450 cDNAs in human lymphoblastoid cells (1992) (1)
EFFECT OF 3-METHYLCHOLANTHRENE ON AMINO ACID INCORPORATION INTO RAT LIVER PROTEIN. (1963) (1)
Cytochrome P450 (P450) mediated H2O2 production and its role in mutagenesis (1990) (0)
Cytochrome P-450 epitope typing in animals and humans with monoclonal antibodies to ethanol induced rat liver microsomal cytochrome P-450 (P-450et) (1986) (0)
Development and application of human cell lines engineered to metabolically activate structurally diverse environmental mutagens (1993) (0)
Genetic and environmental factors in experimental and human cancer : proceedings of the 10th international symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1979 (1980) (0)
Stereochemical Aspects of Benzo[A]Pyrene Metabolism and Biochemical Individuality in Human Cells (1980) (0)
Environment, Chemistry, and metabolism (2012) (0)
Monoclonal antibody directed phenotyping of cytochrome p 450 in animal and human tissues (1985) (0)
Carcinogenesis, the environment, and gene action. New Horizons for Radiologists Lecture. (1971) (0)
Alterations in leukocyte aryl hydrocarbon hydroxylase activity associated with treatment and age in psoriasis patients and healthy individuals (2004) (0)
Contents, Vol. 40, 1990 (2004) (0)
Cytochrome P450s and molecular epidemiology (1993) (0)
Mono-oxygenase catalyzed reactions and binding of benzo(a)pyrene to DNA in human tissues. Role in susceptibility to chemically induced cancer (1987) (0)
Immortalized human cell lines containing cytochrome p450 genes exogenous. (1993) (0)
Subject Index, Vol. 40, 1990 (2004) (0)
AUTOCATALYZED COVALENT BINDING OF 3H(-)t-7,8-DIOL BENZO(a)PYRENE TO MIXED-FUNCTION OXIDASE ENZYMES AND DNA: THE ROLE OF EPOXIDE HYDRATASE (1980) (0)
Cytochrome P-450: the Japanese connection. (1993) (0)
ANALYSIS OF THE REGULATION OF MICROSOMAL HYDROXYLASES AND THEIR ROLE IN POLYCYCLIC HYDROCARBON CARCINOGENESIS AND TOXICITY (1973) (0)
Immortalized human cell lines which exogenous cytochrome P-450 gen contained (1994) (0)
Aryl hydrocarbon hydroxylase activity in the adrenal gland of the rat and mouse: effect of 3-methylcholan- threne treatment. Abstr. (1979) (0)
Metabolism of Methylbutyl- and Methylamylnitrosamine by Rat and Human Esophagus and Other Tissues and Induction of Esophageal Adenocarcinoma in Rats (1994) (0)
Regulation of Enzyme Amounts in Developing Liver (2005) (0)
Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors (1988) (0)
Cytochrome P-450 That Metabolizes Aniline and Nitrosamines Monoclonal Antibodies to Ethanol-induced Rat Liver (2006) (0)
Aryl hydrocarbon hydroxylase and benzo[a] pyrene metabolism in rodent liver and human cels. (1980) (0)
Structural characterization of a monoclonal antibody immunopurified pulmonary cytochrome P-450 from 3-methylcholanthrenetreated rats (1986) (0)
Analysis Activities of Human Cytochrome and Expression P 450 Catalytic (2006) (0)
Monoclonal antibody based radioimmunoassay of cytochrome p 450 isozymes in rat epidermis (1988) (0)
Monoclonal Antibody Analyses of Microsomal Human Drug Metabolism and Multifunctional Cytochrome P450 (2012) (0)
Immunochemical analysis of cytochromes P-450 in teleosts with polyclonal antibodies to cytochrome P-450E (1986) (0)
Interindividualand IntraindividualVariationsin Aryl HydrocarbonHydroxylasein Monocytesfrom Monozygoticand DizygoticTwins (1977) (0)
Phenotyping of Phenytoin Treated Rat Liver Cytochrome P-450 with Monoclonal Antibodies (1991) (0)
U.S.‐Japan Seminar on Cytochrome P‐450 and Carcinogenesis (1989) (0)
Monoclonal antibody-directed characterization of rat hepatic P450 catalyzing the omega-1 and omega-2 hydroxylation of prostaglandins. (1989) (0)
Phenotyping Cytochromes P450 with Monoclonal Antibodies (1984) (0)

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