Hachiro Sugimoto

Q: What Schools Are Affiliated With Hachiro Sugimoto

Hachiro Sugimoto is affiliated with the following schools: University of Tokyo, Doshisha University, Institute of Science Tokyo, Osaka University, Kyoto University, Chuo University

Hachiro Sugimoto's AcademicInfluence.com Rankings

Hachiro Sugimoto

Chemistry

#1043

World Rank

#1665

Historical Rank

Organic Chemistry

#1034

World Rank

#1167

Historical Rank

chemistry Degrees

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Chemistry

Hachiro Sugimoto's Degrees

Bachelors Chemistry Kyoto University
Masters Chemistry Kyoto University
PhD Chemistry Kyoto University

Why Is Hachiro Sugimoto Influential?

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According to Wikipedia, Hachiro Sugimoto is a Japanese chemist and pharmacologist, known for his discovery of Donepezil. Research Sugimoto's research on E2020 , an acetylcholinesterase inhibitor, first began at Eisai's Tsukuba Research Laboratories in 1983, because his mother suffered from dementia. At that time, there was a hypothesis suggested that acetylcholines were closely linked to abnormal decreases in memory function in patients with Alzheimer's disease. His research group was finally able to successfully create Donepezil with a promising enough profile for the compound to become a drug candidate.

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Hachiro Sugimoto's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Microglia‐derived interleukin‐6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells (2007) (281)
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. (1995) (265)
Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. (2000) (262)
Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. (2008) (200)
Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons (2003) (196)
Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor. (2002) (187)
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade (2006) (176)
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1 (2006) (126)
LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11 (2008) (109)
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors (2010) (108)
The rationale for E2020 as a potent acetylcholinesterase inhibitor. (1996) (101)
Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation (2008) (98)
Multifunction of myricetin on Aβ: Neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases (2008) (91)
PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes. (2010) (90)
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups (2015) (81)
Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells. (2011) (80)
Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice (2007) (79)
Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. (2011) (74)
QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. (1992) (72)
Three distinct neuroprotective functions of myricetin against glutamate‐induced neuronal cell death: Involvement of direct inhibition of caspase‐3 (2008) (72)
Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives. (1990) (69)
Distinct mechanisms underlie distinct polyphenol‐induced neuroprotection (2006) (68)
Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity (2007) (68)
Sox21 Promotes Hippocampal Adult Neurogenesis via the Transcriptional Repression of the Hes5 Gene (2012) (61)
Donepezil hydrochloride: a treatment drug for Alzheimer's disease. (2001) (59)
Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds (1992) (58)
The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses. (1996) (58)
Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons. (2005) (58)
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives. (1992) (56)
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. (2009) (56)
Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors. (2016) (55)
Interactions of endothelin receptor subtypes A and B with Gi, Go, and Gq in reconstituted phospholipid vesicles. (1999) (52)
Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene (2009) (51)
Structure-activity relationships of acetylcholinesterase inhibitors: Donepezil hydrochloride for the treatment of Alzheimer’s Disease (1999) (51)
Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor. (2006) (50)
Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization. (2012) (49)
Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum (2002) (49)
Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase (1992) (49)
Amyloid precursor protein promotes endoplasmic reticulum stress‐induced cell death via C/EBP homologous protein‐mediated pathway (2009) (47)
The new approach in development of anti-Alzheimer's disease drugs via the cholinergic hypothesis. (2008) (46)
Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis). (2012) (45)
Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. (2006) (44)
Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein. (2014) (42)
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity. (2006) (42)
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease. (2008) (41)
Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells. (2007) (35)
Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil (2008) (34)
Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice (2008) (34)
Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases. (2008) (31)
PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8. (2017) (30)
Serofendic acid prevents 6‐hydroxydopamine‐induced nigral neurodegeneration and drug‐induced rotational asymmetry in hemi‐parkinsonian rats (2005) (29)
Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment. (2008) (27)
Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen–glucose depletion (2010) (26)
Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons. (2003) (26)
Serofendic Acid, a Sulfur-Containing Diterpenoid Derived from Fetal Calf Serum, Attenuates Reactive Oxygen Species-Induced Oxidative Stress in Cultured Striatal Neurons (2004) (26)
PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo (2015) (25)
Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation. (2006) (24)
Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by alpha- and gamma-secretase. (2008) (24)
N‐cadherin‐based adhesion enhances Aβ release and decreases Aβ42/40 ratio (2009) (21)
Decrease of Amyloid-β Levels by Curcumin Derivative via Modulation of Amyloid-β Protein Precursor Trafficking. (2017) (19)
α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionate attenuates glutamate‐induced caspase‐3 cleavage via regulation of glycogen synthase kinase 3β (2008) (19)
Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors. (2010) (19)
Synthesis and absolute configuration of serofendic acids (2002) (18)
Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. (1992) (16)
Highly water pressurized brown rice improves cognitive dysfunction in senescence-accelerated mouse prone 8 and reduces amyloid beta in the brain (2018) (16)
Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors. (2010) (15)
Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons. (2008) (15)
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta. (2008) (15)
Synthesis and pharmacological profile of serofendic acids A and B. (2007) (13)
Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation (2020) (13)
[Discovery and development of donepezil hydrochloride for the treatment of Alzheimer's disease]. (1999) (13)
Synthesis of 1-benzyl-4-[(5,6-dimethoxy[2-14C]-1-indanon)-2-yl]-methylpiperidine hydrochloride (E2020-14C) (1989) (13)
Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells (2009) (12)
Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes. (2009) (12)
AMPA reduces surface expression of NR1 through regulation of GSK3&bgr; (2009) (11)
Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2. (2010) (11)
A molecular pathway involved in the generation of microtubule-associated protein 2-positive cells from microglia. (2008) (11)
Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons (2005) (11)
Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats. (2008) (10)
Synthesis and neuroprotective effects of serofendic acid analogues. (2006) (10)
Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints. (2011) (10)
[Development of anti-Alzheimer's disease drug based on beta-amyloid hypothesis]. (2010) (10)
Influence of Ultra-High Hydrostatic Pressurizing Brown Rice on Cognitive Functions and Mental Health of Elderly Japanese Individuals: A 2-Year Randomized and Controlled Trial. (2019) (10)
Synthesis and Structure‐Activity Relationships of Acetylcholinesterase Inhibitors: 1‐Benzyl‐4‐((5,6‐dimethoxy‐1‐oxoindan‐2‐yl)methyl) piperidine Hydrochloride and Related Compounds. (1996) (9)
Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation. (2006) (9)
Identification of an antiamyloidogenic substance from mulberry leaves (2009) (8)
Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression (2010) (8)
The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice. (2019) (8)
Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation (2020) (7)
Long-Term Ultra-High Hydrostatic Pressurized Brown Rice Intake Prevents Bone Mineral Density Decline in Elderly Japanese Individuals. (2019) (7)
Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity. (2009) (6)
Synthesis of optically active methyl 7 beta-hydroxykaurenoate with potent neuroprotective activity. (2004) (6)
Functional and molecular interactions between Rac1 and FE65 (2011) (5)
Discovery and Development of Donepezil Hydrochloride for Treatment of Alzheimer's Disease (1998) (4)
Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis (2021) (4)
A role for SOX2 in the generation of microtubule-associated protein 2-positive cells from microglia. (2009) (4)
Inhibition of Amyloid β Fibrillation by Nanoparticles Composed of Ovalbumin-derived Amphiphilic Peptides (2020) (3)
Basic fibroblast growth factor promotes the generation of microtubule-associated protein 2-positive cells from microglia. (2009) (3)
Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors : 1-Benzyl-4-[ ( 5 , 6-dimethoxy-l-oxoindan-2-yl ) methyl ] piperidine Hydrochloride and Related Compounds (2001) (3)
A comparison of the amyloid β fibril-destabilizing activities of leaves among varieties of the mulberry. (2009) (3)
Novel Piperidine Derivatives. Synthesis and Antiacetylcholinesterase Activity of 1‐Benzyl‐4‐(2‐(N‐benzoylamino)ethyl)piperidine Derivatives. (2010) (3)
Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins (2020) (3)
[Scope and limitations of acetylcholinesterase inhibitors]. (2004) (3)
Integrin-Associated Protein Promotes Neuronal Differentiation of Neural Stem/Progenitor Cells (2015) (2)
United States Patent ( 19 ) Sugimoto et al . 54 CYCLIC AMINE COMPOUNDS WITH ACTIVITY AGAINST ACETYLCHOLINESTERASE (2017) (2)
[Fundamental study of memory impairment and non-cognitive behavioral alterations in APPswe/PS1dE9 mice]. (2015) (2)
Synthesis of 14C-labelled 2-[4-(p-fluorobenzoyl)piperidin-1-yl]-2′-acetonaphthone hydrochloride (E-2001-14C) (1989) (2)
Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons. (2010) (1)
Quantitative structure-activity relationship. QSAR, analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. [Erratum to document cited in CA116(9):83138p] (1992) (1)
donepezil against glutamate neurotoxicity in rat cortical neurons (2003) (1)
The New Generation of Acetylcholinesterase Inhibitors (2002) (1)
AMPA protects cultured neurons against glutamate cytotoxicity via activation of phosphatidylinositol-3 kinase/Akt and inactivation of GSK3β and caspase-3 (2007) (1)
Development of anti-Alzheimer′s Disease Drug Based on β-Amyloid Hypothesis (2010) (1)
Piperidine derivatives as anticholinergic substances Link (1988) (0)
Distinct roles of Sox family transcription factors in adult neurogenesis (2009) (0)
Cyclic amines and pharmacological compounds (1988) (0)
[New approaches for the development of anti-Alzheimer's disease drugs based on the cholinergic hypothesis and amyloid hypothesis]. (2008) (0)
Effects of chronic treatment with donepezil via α7-nicotinic receptor and phosphatidylinositol 3-kinase cascade (2007) (0)
Involvement of integrin-associated protein form 2 in neurona differentiation of neural stem/progenitor cells (2009) (0)
Cyclic amides derivatives. (1991) (0)
4- 2-indanyl-1-on alkyl-piperidin Derivate als anticholinerge Linkstoffe (1988) (0)
P4-266 Protective effects of nicotinic receptor stimulation with nicotine or acetylcholinesterase inhibitors against beta amyloid- or glutamate-induced neuronal death (2006) (0)
Theophylline and theobromine derivatives, processes for their preparation and therapeutic composition containing same (1981) (0)
Cyclic amine compounds, pharmaceutical compositions containing them and the use of the compounds for the manufacture of a drug for senile dementia particularly (1996) (0)
Piperidine derivatives as anticholinergic agents. (1988) (0)
Molecular mechanism of amyloid precursor protein-induced cytotoxicity (2010) (0)
2- (indan-1-one-2-yl-alkyl) -1-phenyl- piperidines and methods for their preparation. (1988) (0)
Piperidine derivatives or salts thereof, and pharmaceutical compositions containing the compounds (1986) (0)
The piperidine derivative, its use and pharmaceutical composition containing them. (1986) (0)
Synthesis of 14C-labelled (S)-(+)-2-[4-(p-fluorobenzoyl)-1-piperidyl]-1-naphthylethanol hydrochloride (1990) (0)
The method of piperidiene derivative (1986) (0)
[Scope and limitation of medical treatment for Alzheimer' s disease]. (2011) (0)
1- (aryl or cyclohexyl) -alkylpiperidinforbindelser, pharmaceutical compositions containing these and the use of the compounds for preparing drugs (1988) (0)
Synthesis of Optically Active Methyl 7β‐Hydroxykaurenoate with Potent Neuroprotective Activity. (2005) (0)
Altered synaptic transmission in APPswe and PS1 double transgenic mice (2006) (0)
Derivatives of theophylline and theobromine (1981) (0)
The role of C-terminus of amyloid precursor protein under endoplasmic reticulum stress (2007) (0)
Theobromine derivatives, processes for their preparation and compositions containing them drug (1980) (0)
Studies on Homopiperazine Derivatives: Conformational Analysis of 2-(4-Acylhomopiperazin-1-yl)-4-amino-6,7-dimethoxyquinazolines by Nmr (1976) (0)
NSC23766, a Rac1 inhibitor, protects neurons against Abeta-induced neurotoxicity via inactivation of GSK3beta (2009) (0)
4- (indan-1-one-2-yl-alkyl) 1-phenylalkyl-piperidines and processes for their preparation (1988) (0)
Cyclic amino compounds and pharmaceutical compositions containing these (1988) (0)
Discovery and Development of Donepezil Hydrochloride for Treatment of Alzheimer′s Disease (1998) (0)
Drugs for the treatment of pain, fever, tissue and / or bone and joint inflammation with a content of theobromine or theophylline derivatives as active ingredient (1983) (0)
Derivatives of cyclic amides (1991) (0)
Process for the preparation of a medicament useful for the cyclic amide derivative (1991) (0)
Quinazoline compounds and processes for their preparation (1973) (0)
Angiotensin receptor type 1 regulate glutamate transporter 1 expression (2009) (0)
1,4-substituted piperidines as inhibitors acetilcozinesterasa and their use as inhibitors of Alzheimer's disease. (1988) (0)
Piperidine derivative, its use and pharmaceutical compound containing it. (1986) (0)
Polypeptides, and pharmaceutical compositions containing these compounds (1989) (0)
Process for the preparation of a medicament useful piperidine derivatives or a pharmaceutically acceptable salt thereof (1988) (0)
Process for the preparation of derivatives of cyclic amides and of pharmaceutical compositions that contain them (1991) (0)

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What Schools Are Affiliated With Hachiro Sugimoto?

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