Hakon Leffler
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Hakon Leffler's Degrees
- PhD Computer Science Norwegian University of Science and Technology
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(Suggest an Edit or Addition)Hakon Leffler's Published Works
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Published Works
- Galectins. Structure and function of a large family of animal lectins. (1994) (1454)
- Galectins: A family of animal β-galactoside-binding lectins (1994) (855)
- Introduction to galectins (1997) (644)
- Chemical identification of a glycosphingolipid receptor for Escherichia coli attaching to human urinary tract epithelial cells and agglutinating human erythrocytes (1980) (515)
- Regulation of Alternative Macrophage Activation by Galectin-31 (2008) (467)
- Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. (2012) (372)
- Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens* (2008) (352)
- Galectins at a glance (2018) (343)
- Glycolipid receptors for uropathogenic Escherichia coli on human erythrocytes and uroepithelial cells (1981) (305)
- Galectin‐3, a marker for vacuole lysis by invasive pathogens (2010) (283)
- X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution. (1994) (278)
- Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1----4Gal-containing glycosphingolipids. (1985) (269)
- Structure of the O-Glycans in GlyCAM-1, an Endothelial-derived Ligand for L-selectin (1995) (258)
- Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosides. (1986) (256)
- Multiple soluble beta-galactoside-binding lectins from human lung. (1987) (253)
- Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells (1983) (252)
- L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity. (1993) (248)
- Phylogenetic analysis of the vertebrate galectin family. (2004) (248)
- Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. (2015) (238)
- X-ray Crystal Structure of the Human Galectin-3 Carbohydrate Recognition Domain at 2.1-Å Resolution* (1998) (227)
- Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion1 (2008) (226)
- Salivary Agglutinin, Which Binds Streptococcus mutansand Helicobacter pylori, Is the Lung Scavenger Receptor Cysteine-rich Protein gp-340* (2000) (225)
- Galectin-3 activates the NADPH-oxidase in exudated but not peripheral blood neutrophils. (1998) (214)
- Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction. (2005) (208)
- Correlation of P blood group, vesicoureteral reflux, and bacterial attachment in patients with recurrent pyelonephritis. (1983) (203)
- Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3 (2010) (203)
- Molecular Characterization of α–Lactalbumin Folding Variants That Induce Apoptosis in Tumor Cells* (1999) (185)
- Inhibition of experimental ascending urinary tract infection by an epithelial cell-surface receptor analogue (1982) (185)
- X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution. (1998) (174)
- Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway. (1993) (174)
- Structures of blood group glycosphingolipids of human small intestine. A relation between the expression of fucolipids of epithelial cells and the ABO, Le and Se phenotype of the donor. (1987) (171)
- The animal lectin galectin-3 interacts with bacterial lipopolysaccharides via two independent sites. (1996) (168)
- Apical Sorting by Galectin‐3‐Dependent Glycoprotein Clustering (2007) (167)
- Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain. (1993) (162)
- Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. (2007) (157)
- Identification of the sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin. (1994) (150)
- Influence of blood group on the availability of receptors for attachment of uropathogenic Escherichia coli (1986) (148)
- Galectin-4 in normal tissues and cancer (2003) (146)
- Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. (2008) (145)
- Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells. (2006) (139)
- Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions. (2004) (139)
- Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease (2019) (137)
- Soluble lactose-binding vertebrate lectins: a growing family. (1989) (137)
- Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. (2003) (132)
- The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics (2011) (131)
- Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins. (1995) (131)
- The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. (2002) (129)
- Dendritic Cell Maturation Results in Pronounced Changes in Glycan Expression Affecting Recognition by Siglecs and Galectins1 (2007) (125)
- Macrophage inflammatory protein-2 is required for neutrophil passage across the epithelial barrier of the infected urinary tract. (1999) (125)
- Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils. (1999) (122)
- C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions. (2005) (122)
- Ligand Induced Galectin-3 Protein Self-association* (2012) (115)
- Galectin‐3‐Binding Glycomimetics that Strongly Reduce Bleomycin‐Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition (2016) (111)
- Influence of adhesins on the interaction of Escherichia coli with human phagocytes (1984) (111)
- L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I. (1993) (111)
- Sequence and Mapping of Galectin-5, a β-Galactoside-binding Lectin, Found in Rat Erythrocytes (*) (1995) (108)
- Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. (1992) (106)
- Activation of the Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase by Galectin-11 (2002) (106)
- Virulence-associated traits in Escherichia coli causing first and recurrent episodes of urinary tract infection in children with or without vesicoureteral reflux. (1984) (106)
- The receptor repertoire defines the host range for attaching Escherichia coli strains that recognize globo-A (1991) (103)
- Lipopolysaccharide-Induced Gelatinase Granule Mobilization Primes Neutrophils for Activation by Galectin-3 and Formylmethionyl-Leu-Phe (2001) (103)
- Galectin‐3 deficiency prevents concanavalin A–induced hepatitis in mice (2012) (102)
- Binding Specificity of Piliated Strains of Escherichia coli and Salmonella typhimurium to Epithelial Cells, Saccharomyces cerevisiae Cells, and Erythrocytes (1981) (100)
- Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. (2010) (96)
- Galectin-4 and Galectin-6 Are Two Closely Related Lectins Expressed in Mouse Gastrointestinal Tract* (1998) (94)
- Novel polyfucosylated N-linked glycopeptides with blood group A, H, X, and Y determinants from human small intestinal epithelial cells. (1989) (92)
- Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein. (1991) (92)
- Primary structure of the soluble lactose binding lectin L-29 from rat and dog and interaction of its non-collagenous proline-, glycine-, tyrosine-rich sequence with bacterial and tissue collagenase. (1993) (88)
- Mutational Tuning of Galectin-3 Specificity and Biological Function* (2010) (86)
- 1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors. (2010) (85)
- Strikingly Different Localization of Galectin-3 and Galectin-4 in Human Colon Adenocarcinoma T84 Cells (1997) (85)
- 3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3. (2005) (83)
- Synthesis of a phenyl thio-beta-D-galactopyranoside library from 1,5-difluoro-2,4-dinitrobenzene: discovery of efficient and selective monosaccharide inhibitors of galectin-7. (2005) (82)
- Glycosphingolipid receptors for Pseudomonas aeruginosa (1990) (82)
- Glycosphingolipids of rat tissues. Different composition of epithelial and nonepithelial cells of small intestine. (1982) (81)
- Adhesion of Escherichia coli in urinary tract infection. (1981) (81)
- Galectins structure and function--a synopsis. (2001) (79)
- Receptor-specific agglutination tests for detection of bacteria that bind globoseries glycolipids (1987) (79)
- Galectin‐3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected (2002) (75)
- Inhibition of galectins with small molecules. (2011) (73)
- Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon. (2001) (73)
- Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides. (2008) (72)
- Low Micromolar Inhibitors of Galectin‐3 Based on 3′‐Derivatization of N‐Acetyllactosamine (2002) (72)
- Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer (2009) (71)
- Sulfated Lewis X Determinants as a Major Structural Motif in Glycans from LS174T-HM7 Human Colon Carcinoma Mucin* (1997) (71)
- Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition. (2006) (68)
- Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3 (2016) (68)
- Selected ion monitoring of glycospingolipid mixtures. Identification of several blood group type glycolipids in the small intestine of an individual rabbit. (1979) (66)
- The role of Galectin-3 in α-synuclein-induced microglial activation (2014) (66)
- An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade. (2019) (65)
- Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding. (2019) (64)
- Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen. (1991) (64)
- Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors. (2005) (63)
- Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins. (2008) (63)
- Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity. (2018) (63)
- Glycosphingolipids and the differentiation of intestinal epithelium. (1981) (63)
- Monosaccharide Derivatives with Low‐Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine–Amide, Phenyl–Arginine, Sulfur–π, and Halogen Bond Interactions (2018) (62)
- Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis (2020) (62)
- Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. (2013) (61)
- Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells. (2008) (61)
- Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity. (1998) (60)
- Studies of Arginine–Arene Interactions through Synthesis and Evaluation of a Series of Galectin‐Binding Aromatic Lactose Esters (2007) (59)
- Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR. (2016) (59)
- Extracellular and intracellular small-molecule galectin-3 inhibitors (2019) (58)
- Taloside Inhibitors of Galectin‐1 and Galectin‐3 (2012) (57)
- Separate oligosaccharide determinants mediate interactions of the low-molecular-weight salivary mucin with neutrophils and bacteria. (1999) (55)
- Binding specificities of wild-type and cloned Escherichia coli strains that recognize globo-A (1989) (54)
- P1 BLOOD GROUP AND URINARY TRACT INFECTION (1981) (54)
- Blood group type glycosphingolipids from the small intestine of different animals analysed by mass spectrometry and thin-layer chromatography. A note on species diversity. (1981) (54)
- Conformational differences in liganded and unliganded states of Galectin-3. (2003) (53)
- Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types. (2012) (52)
- Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual. (2012) (52)
- Sequence and specificity of a soluble lactose-binding lectin from Xenopus laevis skin. (1992) (52)
- Different angioregulatory activity of monovalent galectin-9 isoforms (2018) (52)
- Distance mapping of protein‐binding sites using spin‐labeled oligosaccharide ligands (2001) (51)
- Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context (2018) (51)
- A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model. (2016) (50)
- RECEPTOR ANALOGUES AND ANTI‐PILI ANTIBODIES AS INHIBITORS OF BACTERIAL ATTACHMENT IN VIVO AND IN VITRO * (1983) (50)
- The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin (2018) (50)
- Monovalent interactions of galectin-1. (2010) (50)
- Possible interaction between animal lectins and bacterial carbohydrates. (1994) (49)
- Design and synthesis of galectin inhibitors. (2003) (47)
- The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins* (2011) (47)
- Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis (2017) (47)
- Galectin‐3 deficiency protects pancreatic islet cells from cytokine‐triggered apoptosis in vitro (2013) (46)
- The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading. (2009) (45)
- Characterization of cerebroside (monoglycosylceramide) from the sea anemone, Metridium senile. Identification of the major long-chain base as an unusual dienic base with a methyl branch at a double bond. (1979) (45)
- Bacterial adherence--a pathogenetic mechanism in urinary tract infections caused by Escherichia coli. (1983) (45)
- Galectin-1-Binding Glycoforms of Haptoglobin with Altered Intracellular Trafficking, and Increase in Metastatic Breast Cancer Patients (2011) (44)
- Multimeric Lactoside “Click Clusters” as Tools to Investigate the Effect of Linker Length in Specific Interactions with Peanut Lectin, Galectin‐1, and ‐3 (2010) (44)
- Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans* (2016) (44)
- Intracellular sorting of galectin-8 based on carbohydrate fine specificity. (2007) (44)
- Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3. (2009) (44)
- Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors. (2007) (44)
- The high-molecular-weight human mucin is the primary salivary carrier of ABH, Le(a), and Le(b) blood group antigens. (1993) (43)
- Glycosphingolipids of human urinary tract epithelial cells as possible receptors for adhering Escherichia coli bacteria. (1980) (41)
- The specific glycosphingolipid composition of human ureteral epithelial cells. (1985) (41)
- Characterization of the forssman glycolipid hapten of horse kidney by mass spectrometry. (1974) (39)
- Gal‐3 regulates the capacity of dendritic cells to promote NKT‐cell‐induced liver injury (2015) (39)
- Fluorescence polarization to study galectin-ligand interactions. (2003) (39)
- Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin‐3‐Specific Inhibitors (2013) (39)
- Target cell specificity of wild-type E. coli and mutants and clones with genetically defined adhesins. (1983) (38)
- Variant size- and glycoforms of the scavenger receptor cysteine-rich protein gp-340 with differential bacterial aggregation (2007) (37)
- Synthesis and Evaluation of New Thiodigalactoside‐Based Chemical Probes to Label Galectin‐3 (2009) (37)
- Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors. (2006) (36)
- Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors. (2008) (35)
- Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8. (2008) (35)
- Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine. (2002) (35)
- Aspects on structure and function of pili on uropathogenic Escherichia coli. (1983) (35)
- A sialoglycoprotein complex linked to the microvillus cytoskeleton acts as a receptor for pilus (AF/R1) mediated adhesion of enteropathogenic Escherichia coli (RDEC-1) in rabbit small intestine (1991) (35)
- Sequence, Structure, and Chromosomal Mapping of the MouseLgals6 Gene, Encoding Galectin-6* (1998) (35)
- A novel sulfoglycosphingolipid of mouse small intestine, IV3-sulfogangliotetraosylceramide, demonstrated by negative ion fast atom bombardment mass spectrometry. (1986) (34)
- Protein identification by in-gel digestion, high-performance liquid chromatography, and mass spectrometry: Peptide analysis by complementary ionization techniques (2001) (34)
- Superantigen- and TLR-Dependent Activation of Tonsillar B Cells after Receptor-Mediated Endocytosis 1 (2009) (33)
- Specific pattern of glycosphingolipids enriched in a mucosa scraping of human small intestine (1979) (32)
- Isolation and partial characterization of blood group A and H active glycosphingolipids of rat small intestine. (1982) (32)
- Blood group non-secretors have an increased inflammatory response to urinary tract infection. (1992) (31)
- Multiple soluble vertebrate galactoside-binding lectins. (1988) (30)
- The preparative separation of sialic acid-containing lipids from sulphate group-containing glycolipids from small intestine of different animals. Analysis by thin-layer chromatography and detection of novel species. (1983) (29)
- Gangliotetraosylceramide is a major glycolipid of epithelial cells of mouse small intestine (1982) (28)
- Galectin‐3 type‐C self‐association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function (2018) (27)
- Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists. (2014) (27)
- Enhancement of bound‐state residual dipolar couplings: Conformational analysis of lactose bound to Galectin‐3 (2006) (27)
- Structural characterization of human galectin‐4 C‐terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens (2015) (26)
- Structure determination of blood group type glycolipids of cat small intestine by mass fragmentography (1978) (26)
- Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. (2004) (25)
- TD139, A Novel Inhaled Galectin-3 Inhibitor for The Treatment of Idiopathic Pulmonary Fibrosis (IPF). Results from The First in (IPF) Patients Study. (2016) (24)
- Chemical and clinical studies on the interaction of Escherichia coli with host glycolipid receptors in urinary tract infection. (1982) (24)
- Synthesis of 3-amido-3-deoxy-beta-D-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors (2011) (24)
- Galectin-3 Guides Intracellular Trafficking of Some Human Serotransferrin Glycoforms* (2013) (24)
- Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3′-sulfo-lactose, and 2′-fucosyllactose (2016) (24)
- Recent progress in the understanding of the role of bacterial adhesion in the pathogenesis of urinary tract infection. (1982) (24)
- The structure of sphingomyelin of the honey bee (Apis mellifera). (1972) (24)
- Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease. (2012) (24)
- The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist. (2008) (23)
- Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay. (2003) (23)
- Studies on differentiating epithelial cells of rat small intestine. Alterations in the lipophilic part of glycosphingolipids during cell migration from crypt villus tip. (1982) (23)
- Human trophoblast requires galectin-3 for cell migration and invasion (2019) (23)
- The role of Galectin-3 in α-synuclein-induced microglial activation (2014) (22)
- Sequencing of oligosaccharides by mass spectrometry applied on a 12‐sugar glycolipid (1981) (22)
- Binding to galactose alpha 1----4galactose beta-containing receptors as potential diagnostic tool in urinary tract infection (1987) (21)
- Spindle pole cohesion requires glycosylation-mediated localization of NuMA (2017) (21)
- Arene-anion based arginine-binding motif on a galactose scaffold: structure-activity relationships of interactions with arginine-rich galectins. (2011) (21)
- NON-ANTIBODY-CONTAINING FRACTIONS OF BREAST MILK INHIBIT EPITHELIAL ATTACHMENT OF STREPTOCOCCUS PNEUMONIAE AND HAEMOPHILUS INFLUENZAE (1985) (20)
- Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor (2012) (20)
- Ligand binding and complex formation of galectin-3 is modulated by pH variations. (2014) (20)
- P blood group and proneness to urinary tract infection in Japanese children. (1989) (20)
- Letter to the Editor: Assignment of 1H, 15N and 13C resonances of the carbohydrate recognition domain of human galectin-3 (2001) (20)
- Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13. (1993) (19)
- Non-antibiotic prevention of urinary tract infection (1984) (18)
- Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy subjects. (2012) (17)
- Inhibition of bacterial attachment: examples from the urinary and respiratory tracts. (1990) (17)
- Fecal excretion of intestinal glycosphingolipids by newborns and young children (1987) (17)
- Glycolipids of rat small intestine. Characterization of a novel blood group H-active triglycosylceramide. (1980) (17)
- Human blood group a‐positive and ‐negative strains of rat. Chemical basis as shown by fucolipids of small intestine (1980) (16)
- Low-Molecular Weight Inhibitors of Galectins (2012) (15)
- Structure and Energetics of Ligand–Fluorine Interactions with Galectin‐3 Backbone and Side‐Chain Amides: Insight into Solvation Effects and Multipolar Interactions (2019) (15)
- Structural characterization of glycolipids of rat small intestine having one to eight hexoses in a linear sequence. (1982) (15)
- Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C (2016) (15)
- Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain. (2018) (15)
- Specific adherence of Candida tropicalis to lysophospholipids. (1994) (15)
- Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease. (2002) (15)
- Aminopyrimidine–galactose hybrids are highly selective galectin-3 inhibitors† †Electronic supplementary information (ESI) available: 1H NMR and 13C NMR spectra for all new compounds. See DOI: 10.1039/c9md00183b (2019) (14)
- Separation and characterization of hematosides with different sialic acids and ceramides from rat small intestine. Different composition of epithelial cells versus non-epithelial tissue and of duodenum versus jejunum-ileum. (1981) (14)
- Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C (2021) (13)
- Synthesis of a 3'-naphthamido-LacNAc fluorescein conjugate with high selectivity and affinity for galectin-3. (2006) (13)
- Cobalt-mediated solid phase synthesis of 3-O-alkynylbenzyl galactosides and their evaluation as galectin inhibitors (2006) (13)
- Galectin-2, Galectins-5 and -9, and Galectins-4 and -6 (1997) (13)
- Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve (2007) (13)
- Palmitoyl carnitine, a lysophospholipase-transacylase inhibitor, prevents Candida adherence in vitro. (1997) (13)
- Factor XIII and Tissue Transglutaminase Antibodies in Coeliac and Inflammatory Bowel Disease (2002) (13)
- C1-Galactopyranosyl Heterocycle Structure Guides Selectivity: Triazoles Prefer Galectin-1 and Oxazoles Prefer Galectin-3 (2019) (13)
- In Vivo Veritas - 18F-radiolabeled glycomimetics allow insights into the pharmacological fate of galectin-3 inhibitors. (2019) (13)
- Assignment of 1H, 15N and 13C resonances of the carbohydrate recognition domain of human galectin-3. (2001) (12)
- Different binding specificities of P. mirabilis compared to E. coli. (1982) (12)
- Chemical characterization of penta-, hexa-, hepta-, octa-, and nonaglycosylceramides of rat small intestine having a globoside-like terminus. (1982) (12)
- Host epithelial glycoconjugates and pathogenic bacteria. (1990) (12)
- Galactose-amidine derivatives as selective antagonists of galectin-9 (2016) (11)
- Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins (2014) (10)
- Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis (2016) (10)
- Attachment of Streptococcus Pneumoniae to Human Pharyngeal Epithelial Cells in Vitro—Mechanism of Binding (1984) (10)
- Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II). (1993) (10)
- Galectin-3, A Novel Endogenous Trem2 Ligand, Regulates Inflammatory Response and Aβ Fibrilation in Alzheimer’s Disease (2018) (10)
- Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease (2022) (8)
- Glycoconjugate receptors for bacteria attaching to mucosal sites: examples for Escherichia coli and Streptococcus pneumoniae. (1987) (8)
- Galectin History, Some Stories, and Some Outstanding Questions (2018) (8)
- Fluorescent leukotriene B 4 : potential applications (2005) (8)
- Non-antibiotic prevention of urinary tract infection (1984) (8)
- A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1 (2019) (8)
- Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects. (2019) (8)
- Galectin-8 in IgA Nephritis: Decreased Binding of IgA by Galectin-8 Affinity Chromatography and Associated Increased Binding in Non-IgA Serum Glycoproteins (2011) (8)
- Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression (2021) (7)
- Glycoconjugate Receptors Involved in the Adhesion of Escherichia coli and Streptococcus pneumoniae to Epithelial Cells (1984) (7)
- Molecular mechanisms of adhesion of Streptococcus pneumoniae to human oropharyngeal epithelial cells. (1983) (7)
- Fluorescent leukotriene B4: potential applications Published, JLR Papers in Press, April 1, 2005. DOI 10.1194/jlr.D500005-JLR200 (2005) (6)
- Glycolipids of Rat Small Intestine with Special Reference to Epithelial Cells in Relation to Differentiation (1980) (6)
- Epimers Switch Galectin-9 Domain Selectivity: 3N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal. (2019) (6)
- Sequencing of large oligosaccharides by direct inlet mass spectrometry. Application to cell surface glycolipids (1983) (5)
- The Large Intestine as a Reservoir for Escherichia coli Causing Extra-intestinal Infections (1989) (5)
- Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation. (2021) (5)
- Identifying bacterial receptor proteins and quantifying strength of interactions they mediate. (1995) (5)
- Carbohydrate Recognition and Signaling (2010) (5)
- Cytokine Secretion Galectin-3 in Regulating Leukocyte Viability Differential Roles of Galectin-1 and McEver and (2008) (4)
- Chemokines modulate glycan binding and the immunoregulatory activity of galectins (2021) (4)
- Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins (2021) (4)
- 3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3 (2019) (4)
- Demonstration of complexity of the glycosphingolipid fraction of rat small intestine. (1980) (4)
- Design, Synthesis, and Applications of Galectin Modulators in Human Health (2014) (4)
- Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis (2022) (4)
- Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix. (2022) (3)
- The role of epithelial cell surface glycoconjugates in self-not-self and self-self interaction. (1988) (3)
- Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands (2018) (3)
- Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. (2022) (3)
- Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors (2019) (3)
- Strategies for studying bacterial adhesion in vivo. (1995) (3)
- Letter by Leffler Regarding Article, "Modified Citrus Pectin Prevents Blood-Brain Barrier Disruption in Mouse Subarachnoid Hemorrhage by Inhibiting Galectin-3". (2019) (3)
- Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation (2022) (3)
- Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain (2021) (3)
- Erratum: Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3 (2016) (3)
- Activation by Galectin-3 Regulation of Alternative Macrophage (2008) (2)
- CHAPTER 15 – Carbohydrate Recognition and Signaling (2003) (2)
- TDX, a galectin‐1 and galectin‐3‐specific inhibitor, mitigates VEGF‐A‐induced angiogenesis (2013) (2)
- Selective Monovalent Galectin‐8 Ligands Based on 3‐Lactoylgalactoside (2021) (2)
- Structure and energetics of ligand-fluorine interactions with galectin-3 backbone and side-chain amides - insight into solvation effects and multipolar interactions. (2019) (2)
- Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB (2022) (2)
- Recent progress in the understanding of the role of bacterial adhesion in the pathogenesis of urinary tract infection (2005) (1)
- New inhibitors galectins galactoside (2013) (1)
- [Bacterial binding and urinary tract infections]. (1982) (1)
- Synthesis and Biological Studies of O3‐Aryl Galactosides as Galectin Inhibitors (2021) (1)
- PRIMARY AND SECONDARY GLOMERULONEPHRITIDES 1 (2014) (1)
- Engineering the Ligand Specificity of the Human Galectin‐1 by Incorporation of Tryptophan Analogues (2022) (1)
- Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors (2022) (1)
- Site‐specific N‐glycan profiles of α5β1 integrin from rat liver (2022) (1)
- Low Micromolar Inhibitors of Galectin‐3 Based on 3′‐Derivatization of N‐Acetyllactosamine. (2002) (1)
- Galectin-3c in complex with Bisamido-thiogalactoside derivative 4 (2014) (0)
- Correction to: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease (2023) (0)
- Galectin mediated tethering and neutrophil leukocyte arrest under laminar flow conditions. (2002) (0)
- Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants (2023) (0)
- New inhibitors based galectins 3-triazolyl-galactoside (2005) (0)
- High resolution structure of Human Galectin-7 (2011) (0)
- Synthesis of Novel Triazolyl-Linked Glycohybrids via Click Chemistry (2013) (0)
- Spindle pole cohesion requires glycosylation-mediated localization of NuMA (2017) (0)
- 698 The crystal structure of human Charcot-Leyden crystal protein, eosinophil lysophospholipase, identifies it as a new member of the carbohydrate binding family of animal galectins (1996) (0)
- Galectins Affecting Recognition by Siglecs and Pronounced Changes in Glycan Expression Dendritic Cell Maturation Results in (2007) (0)
- Galectin-9 signaling drives breast cancer invasion through matrix (2021) (0)
- Spotlights on our sister journals: ChemMedChem 18/2016 (2016) (0)
- Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts (2023) (0)
- Different angioregulatory activity of monovalent galectin-9 isoforms (2018) (0)
- Extracellular and intracellular small-molecule galectin-3 inhibitors (2019) (0)
- Receptor-Mediated Endocytosis Activation of Tonsillar B Cells after Superantigen-and TLR-Dependent Cardell and (2009) (0)
- Translational Pharmacology of TD139, an Inhaled Small Molecule Galectin-3 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis (2020) (0)
- Design and Synthesis of Galectin Inhibitors (2004) (0)
- Galactic-1: A Randomized, Double-Blind, Multicentre, Parallel, Placebo-Controlled Phase 2b Study in Subjects with Idiopathic Pulmonary Fibrosis (IPF) Investigating the Efficacy and Safety of TD139, an Inhaled Galectin-3 Inhibitor Administered via a Dry Powder Inhaler Over 52 Weeks (2020) (0)
- Human Neutrophils Major Galectin-3 Receptor Candidates in Identification of CD 66 a and CD 66 b as the Leffler (1999) (0)
- Crystal structure of Apo Human Galectin-3 CRD at 1.08 angstrom resolution, at cryogenic temperature (2011) (0)
- High Resolution X-Ray Structure of Human Galectin-3 in complex with LacNAc (2005) (0)
- Triazole-Linked Glycoconjugates in Allo-, Galacto- And Gulo-Series (2012) (0)
- Crystal structure of Human Galectin-7 in complex with a galactose- benzylphosphate inhibitor (2011) (0)
- Targeting Galectin-3 Attenuates both Corneal Fibrosis and Retinal Gliosis (2014) (0)
- Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance. (2023) (0)
- Copper-Free Huisgen 1,3-Dipolar Cycloaddition to 3-Benzotriazolo-3-Deoxy-β-D-Galactopyranosides – Cyclization of a Secondary Azide and Benzyne (2010) (0)
- Graphical Abstract (2022) (0)
- Soluble lactose-binding lectins from chicken and rat. (1987) (0)
- Adenine Dinucleotide Phosphate Oxidase by Activation of the Neutrophil Nicotinamide (2013) (0)
- The inflammatory mediator galectin-3 is bound to phagocytes in circulation (2010) (0)
- Crystal structure of Human Galectin-3 CRD with glycerol bound at 0.90 angstrom resolution (2011) (0)
- Agglutination TestsforDetection ofBacteria That BindGloboseries Glycolipids (1987) (0)
- Small-Molecule Galectin Inhibitors (2008) (0)
- Attenuation of photoreceptor cell death using the Galectin-3 inhibitor TD139 in an in vitro model of retinal degeneration (2016) (0)
- Galectin-1 Adenine Dinucleotide Phosphate Oxidase by Activation of the Neutrophil Nicotinamide Karlsson (2002) (0)
- Crystal structure of Human Galectin-3 CRD in complex with Lactose at 0.86 angstrom resolution (2011) (0)
- X-ray crystal structures of galectins and their carbohydrate complexes (1996) (0)
- Galectin mediated tethering and arrest of neutrophils under shear flow conditions (2003) (0)
- Rat galectin-1 complex with lactose (2010) (0)
- Essential role of galectin3 in reducing the severity of S. aureus-induced arthritis in mice (2010) (0)
- Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils. (2023) (0)
- Galectin-8 in IgA Nephritis: Decreased Binding of IgA by Galectin-8 Affinity Chromatography and Associated Increased Binding in Non-IgA Serum Glycoproteins (2011) (0)
- Selective Galectin‐8N Ligands: The Design and Synthesis of Phthalazinone‐d‐Galactals (2021) (0)
- Human galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitor (2010) (0)
- Binding Specificities ofWild-Type andClonedEscherichia coli Strains ThatRecognize Globo-A (1989) (0)
- Cubilin and mac2-binding protein are two interacting proteins involved in intrinsic factor-cobalamin binding defects of Grasbeck-Imerslund syndrome (2003) (0)
- P129 Orally active galectin-3 inhibitors attenuate bleomycin induced lung fibrosis (2016) (0)
- A tribute to Françoise Poirier (1954-2018). (2018) (0)
- Human trophoblast requires galectin-3 for cell migration and invasion (2019) (0)
- Influence ofAdhesins ontheInteraction ofEscherichia coli with HumanPhagocytes (1984) (0)
- pneumoniae to Epithelial Cells Glycoconjugate Receptors Involved in the Adhesion of Escherichia coli and Streptococcus (2011) (0)
- Front Cover: Selective Monovalent Galectin‐8 Ligands Based on 3‐Lactoylgalactoside (ChemMedChem 3/2022) (2022) (0)
- Backbone and methyl chemical shift assignments, relaxation data and orderparameters of Galectin-3C in complex with ortho-fluoroaryltriazolegalactopyranosyl 1-thio-D-glucopyranoside derivative (2020) (0)
- Galectin-3 in Regulating Leukocyte Viability Differential Roles of Galectin-1 and (2013) (0)
- Galectin-3, a new LPS binding protein with two functional sites (1995) (0)
- Different affinity of galectins for human serum glycoproteins: Galectin-3 binds many protease inhibitors and acute phase proteins (2008) (0)
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