Haleema Shakur-Still
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Professor of Global Health Clinical Trials and the co-director of London School of Hygiene & Tropical Medicine's Clinical Trials Unit
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Why Is Haleema Shakur-Still Influential?
(Suggest an Edit or Addition)According to Wikipedia, Haleema Shakur-Still is a professor of Global Health Clinical Trials and the co-director of London School of Hygiene & Tropical Medicine's Clinical Trials Unit. Scientific career Shakur-Still has worked in global health clinical trials for over 16 years, specifically focusing on emergency care. Shakur-Still's work includes designing and conducting clinical trials, as well as developing ways to communicate the work to clinicians, policy makers, and the public.
Haleema Shakur-Still's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients (2008) (990)
- The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial (2011) (986)
- Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial (2004) (946)
- Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial (2017) (863)
- Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis (2012) (740)
- Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months (2005) (680)
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. (2010) (485)
- The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. (2013) (457)
- The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial (2010) (287)
- Patient outcome after traumatic brain injury in high-, middle- and low-income countries: analysis of data on 8927 patients in 46 countries. (2009) (243)
- Tranexamic acid for trauma – Authors' reply (2010) (228)
- Effect of consent rituals on mortality in emergency care research (2011) (194)
- Antifibrinolytic drugs for acute traumatic injury. (2004) (183)
- Cost-Effectiveness Analysis of Administering Tranexamic Acid to Bleeding Trauma Patients Using Evidence from the CRASH-2 Trial (2011) (170)
- Comparative effectiveness, safety and acceptability of medical abortion at home and in a clinic: a systematic review. (2011) (164)
- CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial (2012) (164)
- Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial (2020) (124)
- CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. (2012) (123)
- Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial (2012) (119)
- Anti-fibrinolytic agents in post partum haemorrhage: a systematic review (2009) (118)
- Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial (2012) (104)
- European society of intensive care medicine study of therapeutic hypothermia (32-35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial) (2011) (104)
- Prognostic Value of Major Extracranial Injury in Traumatic Brain Injury: An Individual Patient Data Meta-analysis in 39 274 Patients (2012) (98)
- Treatment for primary postpartum haemorrhage. (2014) (91)
- Managing clinical trials (2010) (90)
- HALT-IT - tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial (2014) (87)
- Antifibrinolytic drugs for acute traumatic injury. (2015) (86)
- Predicting early death in patients with traumatic bleeding: development and validation of prognostic model (2012) (86)
- What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies (2019) (72)
- Using a business model approach and marketing techniques for recruitment to clinical trials (2011) (67)
- Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials (2021) (66)
- Antifibrinolytic drugs for treating primary postpartum haemorrhage. (2018) (64)
- Prognosis following head injury: a survey of doctors from developing and developed countries. (2007) (61)
- The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury (2009) (52)
- Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: analysis of data from the WOMAN trial (2018) (51)
- Marketing and clinical trials: a case study (2007) (50)
- Haemostatic drugs for traumatic brain injury. (2015) (48)
- Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation (2010) (47)
- Covariate adjustment increased power in randomized controlled trials: an example in traumatic brain injury. (2012) (47)
- Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials (2016) (40)
- Antifibrinolytic drugs for acute traumatic injury. (2012) (37)
- Hydroxyethyl starch solutions and patient harm (2018) (32)
- Consent in emergency research: new regulations (2005) (30)
- Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms (2017) (30)
- Tranexamic acid for treatment of women with post-partum haemorrhage in Nigeria and Pakistan: a cost-effectiveness analysis of data from the WOMAN trial (2018) (29)
- Trauma care research and the war on uncertainty (2005) (28)
- Comparison of routes for achieving parenteral access with a focus on the management of patients with Ebola virus disease (2015) (26)
- Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: study protocol for an international, randomised, double-blind, placebo-controlled trial (2018) (26)
- Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage (2018) (26)
- Antifibrinolytic drugs for acute traumatic injury. (2011) (25)
- Guide to the design and review of emergency research when it is proposed that consent and consultation be waived (2014) (25)
- Outcome measures in clinical trials of treatments for acute severe haemorrhage (2018) (25)
- Central and statistical data monitoring in the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial (2014) (24)
- Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial (2018) (24)
- Use of the Oxford Handicap Scale at hospital discharge to predict Glasgow Outcome Scale at 6 months in patients with traumatic brain injury (2008) (24)
- Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial. (2020) (24)
- Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial (2018) (23)
- A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS]) (2017) (23)
- Towards sustainable clinical trials. (2007) (22)
- Tranexamic acid for post-partum haemorrhage: What, who and when (2019) (21)
- Development and validation of a prognostic model to predict death in patients with traumatic bleeding, and evaluation of the effect of tranexamic acid on mortality according to baseline risk: a secondary analysis of a randomised controlled trial. (2013) (21)
- The effect of tranexamic acid on the risk of death and hysterectomy in women with post-partum haemorrhage: statistical analysis plan for the WOMAN trial (2016) (19)
- Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial (2020) (17)
- Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial (2020) (17)
- Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients (2020) (16)
- Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients (2020) (16)
- A promise to save 100 000 trauma patients (2012) (15)
- Study protocol for statin web-based investigation of side effects (StatinWISE): a series of randomised controlled N-of-1 trials comparing atorvastatin and placebo in UK primary care (2017) (15)
- Clinical trials in emergency situations (2007) (13)
- Post‐partum haemorrhage and tranexamic acid: a global issue (2018) (13)
- Tranexamic acid for acute gastrointestinal bleeding (the HALT-IT trial): statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial (2019) (13)
- Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers (2021) (13)
- Tranexamic acid through intravenous, intramuscular and oral routes: an individual participant data meta‐analysis of pharmacokinetic studies in healthy volunteers (2019) (12)
- Does tranexamic acid improve outcomes in traumatic brain injury? (2016) (11)
- Cost-effectiveness analysis of tranexamic acid for the treatment of traumatic brain injury, based on the results of the CRASH-3 randomised trial: a decision modelling approach (2020) (11)
- Consent in emergency research (2006) (11)
- The WOMAN trial: clinical and contextual factors surrounding the deaths of 483 women following post-partum haemorrhage in developing countries (2020) (10)
- Tranexamic acid in traumatic brain injury: an explanatory study nested within the CRASH-3 trial (2020) (9)
- What women think about consent to research at the time of an obstetric emergency: a qualitative study of the views of a cohort of World Maternal Antifibrinolytic Trial participants (2018) (9)
- Antifibrinolytic agents in traumatic hemorrhage. (2005) (9)
- Saving lives at Savar. (1979) (9)
- The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial (2018) (8)
- Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2018) (8)
- Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients (2020) (8)
- Pharmacokinetics of tranexamic acid after intravenous, intramuscular, and oral routes: a prospective, randomised, crossover trial in healthy volunteers. (2022) (8)
- Explorer European society of intensive care medicine study of therapeutic hypothermia ( 32-35 ° C ) for intracranial pressure reduction after traumatic brain injury ( the Eurotherm 3235 Trial ) (2017) (7)
- WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section (2021) (7)
- No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial (2019) (7)
- Antifibrinolytic drugs for treating primary postpartum hemorrhage. (2020) (7)
- Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): protocol and statistical analysis plan for a randomized controlled trial (2016) (7)
- Secondary analysis of the WOMAN trial to explore the risk of sepsis after invasive treatments for postpartum hemorrhage (2019) (7)
- Effects of tranexamic acid on platelet function and thrombin generation (ETAPlaT): WOMAN trial sub-study (2016) (7)
- Use of tranexamic acid in major trauma: a sex-disaggragated analysis of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2 and CRASH-3) trials and UK trauma registry (Trauma and Audit Research Network) data. (2022) (6)
- Trial management: we need a cadre of high-class triallists to deliver the answers that patients need (2019) (6)
- Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials (2020) (6)
- Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT. (2021) (6)
- Finding Better Ways to Prevent Postpartum Hemorrhage. (2018) (5)
- Does Tranexamic Acid Prevent Postpartum Haemorrhage? A Systematic Review of Randomized Controlled Trials (2017) (4)
- Review: self management education for adults with asthma improves health outcomes (1998) (4)
- Consent in emergency care research – Authors' reply (2011) (4)
- Good clinical practice in trauma care research: considerations for inter-hospital patient transfers. (2015) (4)
- A COPD self management programme reduced hospital use and improved health status (2003) (4)
- Tranexamic Acid Treatment for Trauma Victims (2021) (4)
- Menstruation should not be overlooked in control of anaemia (2021) (4)
- Tranexamic acid quantification in human whole blood using liquid samples or volumetric absorptive microsampling devices. (2020) (4)
- Accuracy of time to treatment estimates in the CRASH-3 clinical trial: impact on the trial results (2020) (4)
- Tranexamic acid at cesarean delivery: drug-error deaths. (2022) (3)
- Tranexamic acid in trauma: we need stronger global health policy (2013) (3)
- Statistical analysis plan for the WOMAN-ETAPlaT study: Effect of tranexamic acid on platelet function and thrombin generation (2016) (3)
- Tranexamic acid for post-partum haemorrhage in the WOMAN trial – Authors' reply (2017) (3)
- P1133 Tranexamic acid for the treatment of postpartum haemorrhage: An international, randomised, double blind, placebo controlled trial (woman trial – Protocol Number ISRCTN76912190) (2009) (3)
- Clinical Validation of a Volumetric Absorptive Micro-Sampling Device for Pharmacokinetic Studies With Tranexamic Acid (2021) (3)
- The WOMAN Trial: Clinical and Contextual Factors Surrounding the Deaths of 483 Women Following Post-Partum Hemorrhage in Developing Countries (2020) (3)
- Antifibrinolytic Agents in Traumatic Haemorrhage (2005) (2)
- A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan. (2018) (2)
- CRASH2 in Germany [ISRCTN86750102] (2006) (2)
- The effect of statins on muscle symptoms in primary care: the StatinWISE series of 200 N-of-1 RCTs. (2021) (2)
- Tranexamic acid for trauma in the USA: is prejudice a barrier to saving lives? (2022) (2)
- A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT. (2021) (2)
- WITHDRAWN: Haemostatic drugs for traumatic brain injury. (2015) (2)
- Response to: The BRAIN TRIAL: a randomized, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury - authors' reply (2009) (2)
- Antifibrinolytic agents in traumatic hemorrhage: a large scale randomized controlled trial is needed. (2005) (2)
- Postpartum haemorrhage in anaemic women: assessing outcome measures for clinical trials (2021) (2)
- Stillbirths and neonatal deaths among 18 942 women with postpartum hemorrhage: Analysis of perinatal outcomes in the WOMAN trial (2020) (2)
- Extending evidence for the use of tranexamic acid from traumatic haemorrhage to other patients with major bleeding: do we need more than one haemorrhage protocol? The case of gastrointestinal bleeding (2015) (1)
- Should hydroxyethyl starch be banned? – Authors' reply (2018) (1)
- Haemostatic drugs for acute traumatic brain injury (2009) (1)
- WOMAN-2 Pilot Study Data (2019) (1)
- A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan (2019) (1)
- TRIAL : a randomised , placebo controlled trial of a Bradykinin B 2 receptor antagonist ( Anatibant ) in patients with traumatic brain injury (2018) (1)
- Tranexamic acid at cesarean delivery: drug‐error deaths (2022) (1)
- The case for universal access to tranexamic acid (2012) (1)
- WOMAN-PharmacoTXA Trial: Pharmacokinetics and pharmacodynamics of tranexamic acid in women having caesarean section birth - Extended data (2021) (1)
- [Accepted Manuscript] Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials (2016) (1)
- Effects of tranexamic acid treatment in severely and non‐severely injured trauma patients (2022) (1)
- Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review (2022) (1)
- Consent in emergency care research reply (2011) (1)
- Tranexamic acid for trauma Reply (2010) (1)
- Development of a patient reported outcome questionnaire to measure the impact of postpartum blood loss in women with moderate and severe anaemia: A study using a multi-faceted approach (2019) (0)
- A cost-effectiveness and value of information analysis to inform future research of tranexamic acid for older adults experiencing mild traumatic brain injury (2021) (0)
- A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan. (2019) (0)
- Exploratory analyses on death due to bleeding (2013) (0)
- Alternative routes for tranexamic acid treatment in obstetric bleeding (WOMAN-PharmacoTXA trial): a randomised trial and pharmacological study in caesarean section births. (2023) (0)
- Editorial TRAUMATIC BLEEDING: A LARGE SCALE RANDOMISED CONTROLLED TRIAL IS NEEDED AND ALL NEW COLLABORATORS ARE WELCOME (2005) (0)
- Improving outcomes for patients with traumatic brain injury: The CRASH-3 trial in India (2012) (0)
- CRASH-2 trial organization (2013) (0)
- Project submitted to Health Technology Assessment programme (2013) (0)
- Tranexamic acid for bleeding. Much more than a treatment for post-partum haemorrhage. (2022) (0)
- Additional file 5: of Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms (2017) (0)
- What makes a successful trial ? (2010) (0)
- ORIGINAL ARTICLES Covariate adjustment increased power in randomized controlled trials: an example in traumatic brain injury (2012) (0)
- Decolonising knowledge production: our experience researching tranexamic acid for trauma victims (2022) (0)
- The death knell for academic led clinical trials in India? (2013) (0)
- Additional file 3: of Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms (2017) (0)
- Free Bank of Injury and emergency Research Data – freeBIRD (2013) (0)
- Statin treatment and muscle symptoms (2021) (0)
- Human papillomavirus vaccine : life saving treatment or giant experiment ? (2007) (0)
- Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis (2023) (0)
- Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial (2021) (0)
- Tranexamic acid for traumatic brain injury – Authors' reply (2020) (0)
- Total randomisations by geographical region (2013) (0)
- Possible explanations for the results of CRASH (2005) (0)
- Tranexamic acid for gastrointestinal bleeding: can a reduction in the risk of death be discounted? A systematic review and meta-analysis of individual patient data from 64 724 bleeding patients (2023) (0)
- Tranexamic acid at caesarean delivery: drug error deaths. (2022) (0)
- Early administration of tranexamic acid in trauma patients – Authors' reply (2011) (0)
- Economic evaluation of tranexamic acid for the treatment of acute gastrointestinal bleeding: a cost-effectiveness analysis using data from the HALT-IT randomised controlled trial (2022) (0)
- Tranexamic acid at cesarean delivery: Drug‐error deaths (2022) (0)
- Early administration of tranexamic acid in trauma patients reply (2011) (0)
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