Hannele Yki-Järvinen

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#2256

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#3902

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#506

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#931

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Philosophy

Hannele Yki-Järvinen's Degrees

PhD Medicine University of Helsinki
Doctorate Medicine University of Helsinki

Why Is Hannele Yki-Järvinen Influential?

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According to Wikipedia, Hannele Yki-Järvinen is a Finnish endocrinologist, who specialises in non-alcoholic fatty liver disease and the treatment of type 2 diabetes. She is Professor of Medicine at the Department of Medicine, University of Helsinki, Finland. She is also Head of the Division of Diabetes at the Helsinki University Central Hospital. She received the 1995 Young Scientist Anders Jahre Award. She was also the recipient of the Minkowski Award in 1993. Yki-Järvinen was an assistant professor at the University of Texas from 1994 to 2000. She was then an Academy Professor at the Academy of Finland from 1995 to 2000 and from 2000 to 2005.

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Hannele Yki-Järvinen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Clues to the pathogenesis of familial colorectal cancer. (1993) (2811)
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer (1993) (2347)
EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. (2016) (1859)
A serine/threonine kinase gene defective in Peutz–Jeghers syndrome (1998) (1673)
Cancer risk in mutation carriers of DNA‐mismatch‐repair genes (1999) (1287)
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. (1998) (1177)
A new definition for metabolic associated fatty liver disease: an international expert consensus statement. (2020) (1099)
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. (2002) (1090)
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. (2000) (969)
Genetic mapping of a locus predisposing to human colorectal cancer. (1993) (952)
Mutations in the SMAD4/DPC4 gene in juvenile polyposis. (1998) (946)
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. (2014) (842)
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. (2000) (842)
Fatty Liver: A Novel Component of the Metabolic Syndrome (2007) (829)
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. (1987) (820)
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. (1994) (667)
Peutz–Jeghers syndrome: a systematic review and recommendations for management (2010) (662)
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts (2013) (656)
Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. (1988) (643)
Overproduction of large VLDL particles is driven by increased liver fat content in man (2006) (638)
Guidelines for the clinical management of familial adenomatous polyposis (FAP) (2008) (635)
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. (2009) (621)
Life‐time risk of different cancers in hereditary non‐polyposis colorectal cancer (hnpcc) syndrome (1995) (620)
Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group. (2000) (589)
The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome (2008) (551)
Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. (2004) (542)
Population-based molecular detection of hereditary nonpolyposis colorectal cancer. (2000) (538)
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis (1997) (522)
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling (2009) (520)
Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. (1995) (519)
Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein. (1988) (501)
From the metabolic syndrome to NAFLD or vice versa? (2010) (467)
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. (2000) (454)
Liver fat in the metabolic syndrome. (2007) (440)
Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study (2006) (439)
Duodenal adenomatosis in familial adenomatous polyposis (2004) (410)
Acquired Obesity Is Associated with Changes in the Serum Lipidomic Profile Independent of Genetic Effects – A Monozygotic Twin Study (2007) (389)
Gene expression in human NAFLD. (2008) (368)
Dietary fat content modifies liver fat in overweight nondiabetic subjects. (2005) (367)
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. (2004) (365)
CTCF/cohesin-binding sites are frequently mutated in cancer (2015) (359)
Better survival rates in patients with MLH1-associated hereditary colorectal cancer. (1996) (359)
Natural course of insulin resistance in type I diabetes. (1986) (346)
FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study (2011) (346)
Physical Inactivity and Obesity: A Vicious Circle (2008) (346)
Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. (2000) (345)
Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes. (2005) (344)
Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk (2004) (337)
Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. (1995) (334)
Founding mutations and Alu-mediated recombination in hereditary colon cancer (1995) (334)
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer (1994) (328)
Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR). (1997) (327)
Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM (1997) (326)
Causes of weight gain during insulin therapy with and without metformin in patients with Type II diabetes mellitus (1999) (325)
One-Year Treatment With Exenatide Improves β-Cell Function, Compared With Insulin Glargine, in Metformin-Treated Type 2 Diabetic Patients (2009) (322)
Genes Involved in Fatty Acid Partitioning and Binding, Lipolysis, Monocyte/Macrophage Recruitment, and Inflammation Are Overexpressed in the Human Fatty Liver of Insulin-Resistant Subjects (2007) (319)
Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. (2016) (314)
Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) (314)
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes (2010) (314)
Combination therapies with insulin in type 2 diabetes. (2001) (307)
Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity (2007) (305)
Effects of Oral and Transdermal Estrogen Replacement Therapy on Markers of Coagulation, Fibrinolysis, Inflammation and Serum Lipids and Lipoproteins in Postmenopausal Women (2001) (301)
Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus. (1992) (297)
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans (2009) (297)
Physical training and insulin sensitivity. (1986) (296)
Kinetics of glucose disposal in whole body and across the forearm in man. (1987) (290)
Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. (2003) (288)
Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity (2008) (281)
Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. (1996) (278)
Insulin-induced vasodilatation: physiology or pharmacology? (1998) (273)
Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. (2001) (264)
Fat in the liver and insulin resistance (2005) (262)
Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). (2001) (261)
Effects of Body Composition on Insulin Sensitivity (1983) (259)
Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. (2006) (258)
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. (1999) (257)
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. (2009) (257)
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. (2001) (255)
Female fecundity before and after operation for familial adenomatous polyposis (2003) (254)
DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. (1996) (248)
New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 2 Diabetes Using Oral Agents and Basal Insulin: Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (EDITION 2) (2014) (247)
The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. (2001) (236)
The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. (1994) (234)
Insulin Therapy Induces Antiatherogenic Changes of Serum Lipoproteins in Noninsulin‐Dependent Diabetes (1988) (234)
Hyperglycemia Decreases Glucose Uptake in Type I Diabetes (1987) (231)
Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars (2018) (230)
Effects of Exenatide on Measures of β-Cell Function After 3 Years in Metformin-Treated Patients With Type 2 Diabetes (2011) (226)
Supraphysiological Hyperinsulinemia Increases Plasma Leptin Concentrations After 4 h in Normal Subjects (1996) (223)
Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans (2011) (221)
Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver (2009) (221)
Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. (2004) (216)
Pathogenesis of non-insulin-dependent diabetes mellitus (1994) (215)
Gender and Insulin Sensitivity in the Heart and in Skeletal Muscles: Studies Using Positron Emission Tomography (1995) (213)
Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer) (1991) (212)
The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia. A prospective follow-up study. (1998) (208)
Early Cholecystectomy for Acute Cholecystitis: A Prospective Randomized Study (1980) (207)
Anastomotic leakage after anterior resection of the rectum. (1994) (206)
Explaining the Familial Colorectal Cancer Risk Associated with Mismatch Repair (MMR)-Deficient and MMR-Stable Tumors (2007) (206)
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease (2016) (205)
Effect of liver fat on insulin clearance. (2007) (204)
Rosiglitazone in the Treatment of Haart-Associated Lipodystrophy – a Randomized Double-Blind Placebo-Controlled Study (2002) (204)
Dose-response characteristics for suppression of low molecular weight plasma insulin-like growth factor-binding protein by insulin. (1989) (203)
Patient-level meta-analysis of the EDITION 1, 2 and 3 studies: glycaemic control and hypoglycaemia with new insulin glargine 300 U/ml versus glargine 100 U/ml in people with type 2 diabetes (2015) (203)
Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort. (2020) (202)
Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilatation in vivo. (1999) (202)
Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance. (1999) (201)
Clinical features of colorectal carcinoma in cancer family syndrome (1986) (198)
Low-level microsatellite instability in most colorectal carcinomas. (2002) (197)
Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome (2007) (197)
Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects. (1998) (196)
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. (2012) (189)
Features of gastric cancer in hereditary non‐polyposis colorectal cancer syndrome (1997) (187)
Metabolic basis of hypotriglyceridemic effects of insulin in normal men. (1997) (187)
Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. (2008) (186)
Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy (2002) (186)
SMAD4 as a Prognostic Marker in Colorectal Cancer (2005) (184)
Relationships Between Plasma Lipoprotein Concentrations and Insulin Action in an Obese Hyperinsulinemic Population (1987) (183)
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. (2003) (181)
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients (2009) (178)
Impaired Responsiveness to NO in Newly Diagnosed Patients With Rheumatoid Arthritis (2002) (178)
Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling (2018) (176)
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. (1999) (174)
Hyperuricemia and insulin resistance. (1994) (174)
Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography. (1996) (174)
Rectal cancer risk in hereditary nonpolyposis colorectal cancer after abdominal colectomy. International Collaborative Group on HNPCC. (1997) (173)
Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations (2009) (173)
Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance (2007) (172)
Impaired endothelium-dependent vasodilation in type 2 diabetes. Relation to LDL size, oxidized LDL, and antioxidants. (1999) (171)
Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. (2002) (169)
Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. (2002) (167)
Advancing the global public health agenda for NAFLD: a consensus statement (2021) (167)
Genetic reconstruction of individual colorectal tumor histories. (2000) (164)
Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra‐abdominal Adipose Tissue, and Serum (2010) (163)
Intra‐adipose sex steroid metabolism and body fat distribution in idiopathic human obesity (2007) (163)
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. (2004) (163)
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome (2005) (163)
Histopathology of colorectal carcinomas and adenomas in cancer family syndrome (1986) (159)
Sex and insulin sensitivity. (1984) (158)
Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. (2003) (156)
Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity. (1999) (154)
Inhibition of Platelet‐Collagen Interaction An In Vivo Action of Insulin Abolished by Insulin Resistance in Obesity (2002) (153)
Negative binomial meta-regression analysis of combined glycosylated hemoglobin and hypoglycemia outcomes across eleven Phase III and IV studies of insulin glargine compared with neutral protamine Hagedorn insulin in type 1 and type 2 diabetes mellitus. (2007) (153)
Apoprotein E Polymorphism and Coronary Artery Disease: Increased Prevalence of Apolipoprotein E‐4 in Angiographically Verified Coronary Patients (1989) (152)
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis (2007) (151)
Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma (1998) (148)
Portal insulin concentrations rather than insulin sensitivity regulate serum sex hormone-binding globulin and insulin-like growth factor binding protein 1 in vivo. (1995) (147)
The PROactive study: some answers, many questions (2005) (147)
A randomised study of colostomies in low colorectal anastomoses. (1997) (145)
Epidemiology of familial adenomatous polyposis in Finland: impact of family screening on the colorectal cancer rate and survival. (1992) (145)
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. (2014) (144)
Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer. (2005) (144)
Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. (2000) (143)
Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM (1998) (143)
Familial juvenile polyposis coli; increased risk of colorectal cancer. (1984) (143)
Endothelial dysfunction in men with small LDL particles. (2000) (143)
Exenatide Affects Circulating Cardiovascular Risk Biomarkers Independently of Changes in Body Composition (2010) (141)
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome. (2007) (141)
A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. (1999) (141)
Abdominal rectopexy with sigmoidectomy vs. rectopexy alone for rectal prolapse: A prospective, randomized study (1992) (140)
Severity, duration, and mechanisms of insulin resistance during acute infections. (1989) (139)
Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency (2014) (138)
Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome (2007) (138)
Ethanol decreases glucose utilization in healthy man. (1985) (137)
LKB1 somatic mutations in sporadic tumors. (1999) (137)
Diminished wave reflection in the aorta. A novel physiological action of insulin on large blood vessels. (1999) (136)
Predictive genetic testing for hereditary non‐polyposis colorectal cancer: Uptake and long‐term satisfaction (2000) (135)
Localization of Rate-Limiting Defect for Glucose Disposal in Skeletal Muscle of Insulin-Resistant Type I Diabetic Patients (1990) (134)
Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes. (2007) (134)
Cumulative Failure Rate of Ileal Pouch-Anal Anastomosis and Quality of Life After Failure (2002) (133)
Effects of Adding Linagliptin to Basal Insulin Regimen for Inadequately Controlled Type 2 Diabetes (2013) (132)
Cancer family syndrome. Genetic analysis of 22 Finnish kindreds. (1986) (132)
Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity. (1998) (132)
Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. (2011) (131)
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans. (2016) (131)
Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus. (1997) (128)
Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM (1996) (126)
Blood transfusion and prognosis in colorectal carcinoma. (1989) (126)
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM. (1998) (126)
Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy (2003) (125)
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans. (2011) (125)
Glycaemic control and hypoglycaemia with new insulin glargine 300 U/ml versus insulin glargine 100 U/ml in people with type 2 diabetes using basal insulin and oral antihyperglycaemic drugs: the EDITION 2 randomized 12‐month trial including 6‐month extension (2015) (125)
Increased Glutamine:Fructose-6-Phosphate Amidotransferase Activity in Skeletal Muscle of Patients With NIDDM (1996) (124)
Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids (2013) (123)
Occurrence of desmoid tumours in familial adenomatous polyposis and results of treatment (1996) (123)
One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress. (2010) (123)
Free fatty acid kinetics and oxidation in congestive heart failure. (1998) (123)
Differential Effects of Oral and Transdermal Estrogen Replacement Therapy on Endothelial Function in Postmenopausal Women (2000) (122)
Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. (1987) (122)
The MDM2 promoter polymorphism SNP309T→G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck (2005) (122)
Interrelationships Among Insulin's Antilipolytic and Glucoregulatory Effects and Plasma Triglycerides in Nondiabetic and Diabetic Patients With Endogenous Hypertriglyceridemia (1988) (121)
Recommendations to improve identification of hereditary and familial colorectal cancer in Europe (2010) (121)
Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins. (2009) (120)
Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations. (1989) (119)
A population-based study on the prevalence of NASH using scores validated against liver histology. (2014) (119)
Ileorectal anastomosis is appropriate for a subset of patients with familial adenomatous polyposis. (2000) (119)
Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance (2015) (119)
Non-alcoholic fatty liver disease and risk of type 2 diabetes. (2016) (118)
Upper gastrointestinal tract polyps in familial adenomatosis coli. (1983) (118)
Impact of screening examinations on survival in familial adenomatous polyposis. (2000) (117)
Family History, Surgery, and APC Mutation Are Risk Factors for Desmoid Tumors in Familial Adenomatous Polyposis: An International Cohort Study (2011) (116)
Stapled vs hand-sutured ileoanal anastomosis in restorative proctocolectomy. A prospective, randomized study. (1993) (115)
Continuous subcutaneous insulin infusion therapy decreases insulin resistance in type 1 diabetes. (1984) (115)
The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality (2021) (114)
Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer. (1999) (114)
Management of duodenal adenomas in 98 patients with familial adenomatous polyposis. (1999) (113)
The fatty liver and insulin resistance. (2005) (112)
Pouchitis--recurrence of the inflammatory bowel disease? (1994) (112)
Mechanisms of Hyperglycemia-Induced Insulin Resistance in Whole Body and Skeletal Muscle of Type I Diabetic Patients (1992) (112)
Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation. (1991) (112)
Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo. (1998) (111)
Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review (2016) (111)
Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer. (2000) (109)
Liver Fat in the Pathogenesis of Insulin Resistance and Type 2 Diabetes (2010) (109)
Frequency of hereditary nonpolyposis colorectal cancer (1995) (108)
Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites. (2016) (106)
One-year sustained glycaemic control and less hypoglycaemia with new insulin glargine 300 U/ml compared with 100 U/ml in people with type 2 diabetes using basal plus meal-time insulin: the EDITION 1 12-month randomized trial, including 6-month extension (2015) (106)
Ectopic fat accumulation: an important cause of insulin resistance in humans. (2002) (106)
Serum HCGβ, CA 72‐4 and CEA are independent prognostic factors in colorectal cancer (2002) (106)
Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study (2007) (106)
Genetic and clinical characterisation of familial adenomatous polyposis: a population based study (2002) (106)
Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families. (1994) (106)
The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. (2005) (104)
Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. (2003) (103)
Candidate driver genes in microsatellite‐unstable colorectal cancer (2012) (103)
Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy. (1999) (103)
Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer (2014) (103)
Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. (2005) (102)
Normalization of Insulin Sensitivity in Type I Diabetic Subjects by Physical Training During Insulin Pump Therapy (1984) (102)
Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. (2015) (101)
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. (2001) (101)
Effect of antilipolysis on heart and skeletal muscle glucose uptake in overnight fasted humans. (1994) (100)
p53 Codon 72 and MDM2 SNP309 Polymorphisms and Age of Colorectal Cancer Onset in Lynch Syndrome (2005) (99)
Increased coagulation factor VIII, IX, XI and XII activities in non‐alcoholic fatty liver disease (2011) (99)
Mechanisms of insulin resistance during acute endotoxemia. (1994) (99)
Insulin sensitivity in newly diagnosed type 1 diabetics after ketoacidosis and after three months of insulin therapy. (1984) (97)
Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome. (1997) (97)
Follow-up of patients operated on for colorectal carcinoma. (1990) (97)
In vivo endothelial dysfunction characterizes patients with impaired fasting glucose. (1999) (97)
Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy (2008) (97)
Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease (2020) (96)
Factors associated with disease activity of pouchitis after surgery for ulcerative colitis (2004) (95)
Insulin therapy improves endothelial function in type 2 diabetes. (2000) (94)
Rectal cancer risk in patients treated for familial adenomatous polyposis (1992) (94)
Inaccuracies in food and physical activity diaries of obese subjects: complementary evidence from doubly labeled water and co-twin assessments (2010) (94)
Pathogenesis and Prevention of the Dawn Phenomenon in Diabetic Patients Treated with CSII (1986) (94)
SMAD genes in juvenile polyposis (1999) (93)
SMAD4 Levels and Response to 5-Fluorouracil in Colorectal Cancer (2005) (93)
Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations (2005) (92)
Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry (1990) (92)
Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative. (1994) (91)
Gastroscopic follow up of pernicious anaemia patients. (1993) (91)
Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. (2017) (91)
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease (2016) (91)
Frequent loss of SMAD4/DPC4 protein in colorectal cancers (2002) (90)
Fructose and insulin sensitivity in patients with type 2 diabetes (1993) (89)
Female fertility and childbirth after ileal pouch–anal anastomosis for ulcerative colitis (2007) (89)
Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors. (2008) (89)
No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies. (2018) (89)
Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus. (1995) (89)
A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden. (1994) (88)
Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus. (1995) (88)
Glucose toxicity. (1992) (88)
Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. (2007) (86)
Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes (2011) (86)
Liver fat and lipid oxidation in humans (2009) (86)
Insulin resistance and endothelial dysfunction. (2003) (85)
No Reduction in Total Hepatic Glucose Output by Inhibition of Gluconeogenesis With Ethanol in NIDDM Patients (1991) (85)
Molecular Analysis of Endometrial Tumorigenesis: Importance of Complex Hyperplasia Regardless of Atypia (2009) (85)
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous. (2005) (85)
Fecal bacteriology and reservoir ileitis in patients operated on for ulcerative colitis (1988) (85)
Brain Metabolic Alterations in Patients with Type 1 Diabetes–Hyperglycemia-Induced Injury (2004) (85)
Segregation of a missense variant in enteric smooth muscle actin γ-2 with autosomal dominant familial visceral myopathy. (2012) (84)
Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. (2004) (84)
Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance (2004) (84)
Initiate Insulin by Aggressive Titration and Education (INITIATE) (2007) (84)
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis. (2012) (84)
No Support for Endoscopic Surveillance for Gastric Cancer in Hereditary Non-Polyposis Colorectal Cancer (2002) (84)
Large genomic rearrangements and germline epimutations in Lynch syndrome (2009) (83)
Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects (2003) (83)
Role of insulin resistance in the pathogenesis of NIDDM (1995) (83)
Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution. (2008) (83)
Acute effects of ethanol and acetate on glucose kinetics in normal subjects. (1988) (82)
Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus. (1992) (82)
Effects of equal weight loss with orlistat and placebo on body fat and serum fatty acid composition and insulin resistance in obese women. (2004) (82)
Use of Genome-Wide Expression Data to Mine the “Gray Zone” of GWA Studies Leads to Novel Candidate Obesity Genes (2010) (81)
Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin. (2015) (81)
Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects (1995) (80)
Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey (2010) (80)
Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. (2021) (80)
Postprandial lipemia associates with liver fat content. (2007) (79)
Gardner's dento-maxillary stigmas in patients with familial adenomatosis coli. (1986) (79)
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity. (2008) (79)
Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study (2017) (78)
Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing (2007) (77)
Unregulated smooth-muscle myosin in human intestinal neoplasia (2008) (77)
Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus. (1997) (77)
Eleven Candidate Susceptibility Genes for Common Familial Colorectal Cancer (2013) (77)
Regulation of Plasma PAI-1 Concentrations in HAART-Associated Lipodystrophy During Rosiglitazone Therapy (2003) (77)
Nutritional modulation of nonalcoholic fatty liver disease and insulin resistance: human data (2010) (76)
Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes. (2003) (76)
Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum. (1988) (76)
Decision analysis in the surgical treatment of patients with familial adenomatous polyposis: a Dutch-Scandinavian collaborative study including 659 patients (2001) (76)
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. (2009) (76)
Bedtime Insulin for Suppression of Overnight Free–Fatty Acid, Blood Glucose, and Glucose Production in NIDDM (1989) (76)
Mucosal argyrophil endocrine cells in pernicious anaemia and upper gastrointestinal carcinoid tumours. (1989) (75)
Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis (2003) (75)
Gene expression signatures for colorectal cancer microsatellite status and HNPCC (2005) (75)
Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and Positron Emission Tomography (1996) (74)
Growth patterns in young adult monozygotic twin pairs discordant and concordant for obesity. (2004) (74)
PNPLA3 mediates hepatocyte triacylglycerol remodeling[S] (2014) (73)
Inhibition of Lipolysis Decreases Lipid Oxidation and Gluconeogenesis From Lactate But Not Fasting Hyperglycemia or Total Hepatic Glucose Production in NIDDM (1993) (72)
Health‐related quality of life in colorectal cancer (2013) (72)
The association between cholangiooaroinoma and hereditary nonpolyposis colorectal carcinoma (2010) (72)
Uridine Supplementation for the treatment of Antiretroviral Therapy-Associated Lipoatrophy: A Randomized, Double-Blind, Placebo-Controlled Trial (2007) (72)
Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins. (2006) (71)
Screening for colorectal carcinoma in cancer family syndrome kindreds. (1987) (71)
Mutations in the Circadian Gene CLOCK in Colorectal Cancer (2010) (70)
Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources. (1991) (70)
Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. (2019) (70)
EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. (2003) (70)
Prognosis of colorectal cancer varies in different high-risk conditions. (1998) (70)
Comparison of the Relative Contributions of Intra‐Abdominal and Liver Fat to Components of the Metabolic Syndrome (2011) (70)
Toxicity of hyperglycaemia in type 2 diabetes. (1998) (69)
Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas (2014) (69)
Worldwide survey among polyposis registries of surgical management of severe duodenal adenomatosis in familial adenomatous polyposis (2003) (69)
Diagnosis of non-alcoholic fatty liver disease (NAFLD) (2016) (69)
Better glycaemic control and less hypoglycaemia with insulin glargine 300 U/mL vs glargine 100 U/mL: 1‐year patient‐level meta‐analysis of the EDITION clinical studies in people with type 2 diabetes (2017) (69)
Insulin-like growth factor binding protein 1 as a novel specific marker of hepatic insulin sensitivity. (2008) (68)
Survival in women with MMR mutations and ovarian cancer: a multicentre study in Lynch syndrome kindreds (2009) (68)
Little evidence for involvement of MLH3 in colorectal cancer predisposition (2003) (68)
Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects (2012) (68)
Dietary carbohydrates and fats in nonalcoholic fatty liver disease (2021) (67)
Relative conributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia. (2000) (67)
Different alterations in the insulin-stimulated glucose uptake in the athlete's heart and skeletal muscle. (1994) (67)
The effect of insulin and FFA on myocardial glucose uptake. (1995) (66)
Mechanisms of hepatic and peripheral insulin resistance during acute infections in humans. (1992) (66)
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. (2010) (65)
LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover (2020) (65)
Familial and Sporadic Inflammatory Bowel Disease: Comparison of Clinical Features and Serological Markers in a Genetically Homogeneous Population (2002) (65)
Is the treatment of metastatic carcinoid tumor with interferon not as successful as suggested? (1991) (65)
Why does obesity cause diabetes? (2022) (64)
Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus. (2008) (64)
Dissociation between insulin sensitivity of glucose uptake and endothelial function in normal subjects (1996) (64)
Fate of the rectal stump after colectomy and ileorectal anastomosis for familial adenomatous polyposis (1997) (64)
Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome. (2001) (64)
Disturbances in β-Cell Function in Impaired Fasting Glycemia (2002) (64)
3.5 Years of Insulin Therapy With Insulin Glargine Improves In Vivo Endothelial Function in Type 2 Diabetes (2004) (64)
Insulin increases blood volume in human skeletal muscle: studies using [15O]CO and positron emission tomography. (1995) (62)
Ketone body production is differentially altered in steatosis and non‐alcoholic steatohepatitis in obese humans (2015) (62)
Gastroduodenal polyps in familial adenomatous and juvenile polyposis. (1986) (62)
Frequent loss of SMAD4/DPC4 protein in colorectal cancers (2002) (62)
Duodenal surveillance improves the prognosis after duodenal cancer in familial adenomatous polyposis (2012) (61)
CEA, CA 242, CA 19-9, CA 72-4 and hCGβ in the Diagnosis of Recurrent Colorectal Cancer (2004) (61)
Endometrial carcinoma in the cancer family syndrome (1991) (61)
Insulin regulation of MCP-1 in human adipose tissue of obese and lean women. (2008) (61)
Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity (2013) (60)
Treatment and follow-up strategies in hereditary nonpolyposis colorectal carcinoma (1993) (60)
Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography. (2000) (60)
In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing’s syndrome is associated with increased regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue (2004) (60)
Colectomy and Ileorectal Anastomosis is still an Option for Selected Patients with Familial Adenomatous Polyposis (2008) (59)
Genomic profile of pseudomyxoma peritonei analyzed using next‐generation sequencing and immunohistochemistry (2015) (59)
Estimating the Probability of Cancer with Several Tumor Markers in Patients with Colorectal Disease (2004) (59)
Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy. (2008) (59)
Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease (2014) (59)
Obesity‐Related Derangements of Coagulation and Fibrinolysis: A Study of Obesity‐Discordant Monozygotic Twin Pairs (2012) (58)
Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects (2005) (58)
Gardner's stigmas in patients with familial adenomatosis coli (1982) (58)
Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy. (2004) (57)
Insulin resistance, arterial stiffness and wave reflection. (2007) (57)
Long term metabolic consequences of ileal pouch–anal anastomosis for ulcerative colitis (2001) (57)
The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study. (1990) (56)
Clinical benefits and mechanisms of a sustained response to intermittent insulin therapy in type 2 diabetic patients with secondary drug failure. (1988) (56)
Acute and chronic effects of hyperglycaemia on glucose metabolism (1990) (56)
Aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin. (1993) (56)
No Evidence for Short-Term Regulation of Plasminogen Activator Inhibitor Activity by Insulin in Man (1992) (56)
Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring high insulin doses. (2008) (56)
Thiazolidinediones and the liver in humans (2009) (56)
Prevalence of primary sclerosing cholangitis in ulcerative colitis patients undergoing proctocolectomy and ileal pouch‐anal anastomosis (2008) (56)
The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge? (2021) (56)
Identification of candidate oncogenes in human colorectal cancers with microsatellite instability. (2013) (56)
Mechanism for Underestimation of Isotopically Determined Glucose Disposal (1989) (56)
Physical fitness, muscle morphology, and insulin-stimulated limb blood flow in normal subjects. (1996) (56)
Colorectal carcinoma before 40 years of age: prognosis and predisposing conditions. (1984) (55)
Site of insulin resistance in type 1 diabetes: insulin-mediated glucose disposal in vivo in relation to insulin binding and action in adipocytes in vitro. (1984) (55)
Biliary involvement in familial adenomatosis coli (1983) (55)
Hyperreactivity to nitrovasodilators in forearm vasculature is related to autonomic dysfunction in insulin-dependent diabetes mellitus. (1997) (55)
Predictors of abnormal cardiovascular autonomic function measured by frequence domain analysis of heart rate variability and conventional tests in patients with type 1 diabetes. (2000) (55)
Exome-wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated with Fatty Liver Disease. (2020) (55)
Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo. (1998) (55)
Increased augmentation of central blood pressure is associated with increases in carotid intima–media thickness in type 2 diabetic patients (2005) (54)
Finnish registry for familial adenomatosis coli. (1984) (54)
Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes. (2002) (54)
Assessment of Adipokine Expression and Mitochondrial Toxicity in HIV Patients With Lipoatrophy on Stavudine- and Zidovudine-Containing Regimens (2005) (54)
Pre-operative serum levels of CA 242 and CEA predict outcome in colorectal cancer. (1996) (54)
Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer. (1998) (53)
Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart. (1999) (53)
Durability of Kock Continent Ileostomy (2003) (53)
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3 (2013) (53)
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non‐alcoholic fatty liver disease (2012) (52)
Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling. (2010) (52)
Psychic disturbances in patients with chronic prostatis. (1981) (52)
The value of a follow-up programme after radical surgery for colorectal carcinoma. (1989) (51)
Improvement of glycemic control by 1 year of insulin therapy leads to a sustained decrease in sE-selectin concentrations in type 2 diabetes. (2001) (51)
BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. (2011) (51)
Cancer family syndrome (1986) (51)
Insulin resistance is a prominent feature of patients with pancreatogenic diabetes. (1986) (51)
Increased expression of the macrophage markers and of 11β-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity (2007) (51)
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis (2020) (50)
Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women. (2000) (50)
Regulation of plasma lactate concentration in resting human subjects. (1990) (50)
Arterial Stiffness in HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy (2005) (50)
Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy. (2007) (50)
Genotype Predicting Phenotype in Familial Adenomatous Polyposis: A Practical Application to the Choice of Surgery (2009) (50)
Short-term effects of prednisone on serum lipids and high density lipoprotein subfractions in normolipidemic healthy men. (1988) (50)
Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver (2004) (49)
Sharing genetic risk with next generation: mutation-positive parents’ communication with their offspring in Lynch Syndrome (2011) (49)
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer (2016) (49)
Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects. (2001) (49)
Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. (2020) (49)
Comparison of restorative proctocolectomy with and without covering ileostomy in ulcerative colitis (1991) (48)
Functional results after restorative proctocolectomy complicated by pouchitis (1997) (48)
Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis (1995) (48)
Influence of body composition on insulin clearance. (1985) (47)
Early detection of colorectal cancer with faecal occult blood test screening (2010) (47)
Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer (1998) (47)
Liver fat content and hepatic insulin sensitivity in overweight patients with type 1 diabetes. (2015) (46)
Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes. (2001) (46)
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report (2017) (46)
Efficacy and Safety of Flexible Versus Fixed Dosing Intervals of Insulin Glargine 300 U/mL in People with Type 2 Diabetes (2016) (46)
Effectiveness of screening for colorectal cancer with a faecal occult-blood test, in Finland (2015) (46)
Insulin resistance in type I diabetes mellitus: a major role for reduced glucose extraction. (1996) (46)
The C/C−13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population (2005) (46)
Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus. (2000) (45)
Combination therapy with insulin and oral agents: optimizing glycemic control in patients with type 2 diabetes mellitus (2002) (45)
Hyperglycemia stimulates carbohydrate oxidation in humans. (1987) (45)
Insulin Secretion and Insulin Sensitivity in People with Impaired Glucose Tolerance (1996) (45)
Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds. (1991) (44)
Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers (2018) (44)
Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men. (2003) (44)
Insulin sensitivity during the menstrual cycle. (1984) (44)
3 Action of insulin on glucose metabolism in vivo (1993) (44)
Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM. (1989) (44)
Endothelial dysfunction in human diabetes (2002) (44)
Relationship between limb and muscle blood flow in man. (1996) (44)
Decreasing triglyceride by gemfibrozil therapy does not affect the glucoregulatory or antilipolytic effect of insulin in nondiabetic subjects with mild hypertriglyceridemia. (1995) (44)
Time and type of prophylactic surgery for familial adenomatosis coli. (1985) (43)
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease (2021) (43)
Background mutation frequency in microsatellite-unstable colorectal cancer. (2007) (43)
Gene expression and immunohistochemistry in adipose tissue of HIV type 1-infected patients with nucleoside analogue reverse-transcriptase inhibitor-associated lipoatrophy. (2009) (43)
Dental anomalies in familial adenomatous polyposis coli. (1987) (43)
The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects, and patients with insulinoma. (1986) (42)
Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposis. (2009) (42)
[Insulin resistance in type I diabetes]. (2010) (42)
The European NAFLD registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease. (2020) (42)
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases (2012) (41)
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues (1997) (41)
Regulation of hexokinase II expression in human skeletal muscle in vivo. (2000) (41)
Insulin increases the release of endothelin in endothelial cell cultures in vitro but not in vivo. (1994) (40)
Survival of patients with pseudomyxoma peritonei treated by serial debulking (2010) (40)
Impaired absorption of cholesterol and bile acids in patients with an ileoanal anastomosis (1997) (40)
Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle (1998) (39)
17β-Estradiol and estradiol fatty acyl esters and estrogen-converting enzyme expression in adipose tissue in obese men and women. (2013) (39)
Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease (2016) (39)
Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes (2015) (39)
Colorectal surveillance in Lynch syndrome families (2013) (39)
Delayed clearance of postprandial large TG-rich particles in normolipidemic carriers of LPL Asn291Ser gene variant. (1999) (39)
Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes. (1999) (38)
Immunohistochemical demonstration of relaxin in the genital tract of men. (1983) (38)
Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers (2006) (38)
Immunohistochemical demonstration of relaxin in the genital tract of pregnant and nonpregnant women. (1983) (38)
Comparing Daily Glycaemic Control with Insulin Glargine added to Oral Agents versus Twice-daily Premixed Insulin Alone in Type 2 Diabetes (2004) (38)
Low HDL cholesterol concentration is associated with increased intima‐media thickness independent of arterial stiffness in healthy subjects from families with low HDL cholesterol (2003) (38)
Adult Hirschsprung's disease (1990) (37)
Surveillance on mutation carriers of DNA mismatch repair genes. (2000) (37)
No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas. (2000) (37)
Chordoma with a massive spindle-cell sarcomatous transformation. A light- and electron-microscopic and immunohistological study. (1987) (37)
Preoperative serum levels of CEA and CA 242 in colorectal cancer. (1995) (36)
Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes. (2000) (36)
MicroRNA-192* impairs adipocyte triglyceride storage. (2016) (36)
Incorporation of [3-3H]Glucose and 2-[1-14C]Deoxyglucose Into Glycogen in Heart and Skeletal Muscle In Vivo: Implications for the Quantitation of Tissue Glucose Uptake (1997) (36)
Vascular actions of insulin in obesity (2000) (36)
NOD2 3020insC Alone Is Not Sufficient for Colorectal Cancer Predisposition (2004) (36)
Distinct molecular profiles in Lynch syndrome‐associated and sporadic ovarian carcinomas (2013) (36)
Disturbances in beta-cell function in impaired fasting glycemia. (2002) (36)
Risk of cancer and secondary proctectomy after colectomy and ileorectal anastomosis in familial adenomatous polyposis (2014) (36)
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms (2016) (36)
Family histories of Type II diabetes and hypertension predict intima–media thickness in patients with Type I diabetes (2002) (35)
Fate of the Rectum after Colectomy with Ileorectal Anastomosis in Ulcerative Colitis (2005) (35)
Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease (2016) (35)
The influence of sample collection methodology and sample preprocessing on the blood metabolic profile. (2015) (35)
Assessment of insulin secretion from the oral glucose tolerance test in white patients with type 2 diabetes. (2000) (35)
Effects of dietary interventions on liver volume in humans (2014) (35)
HUMAN ENDOMETRIUM CONTAINS RELAXIN THAT IS PROGESTERONE‐DEPENDENT (1985) (34)
Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. (2021) (34)
The complex genotype–phenotype relationship in familial adenomatous polyposis (2004) (34)
Genetic testing for polyposis: practical and ethical aspects (2003) (34)
Costs of colorectal cancer in different states of the disease (2015) (34)
Physical fitness and endothelial function (nitric oxide synthesis) are independent determinants of insulin-stimulated blood flow in normal subjects. (1996) (33)
Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential hypertension. (1998) (33)
Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. (1998) (33)
Surveillance in Lynch Syndrome (2005) (33)
Somatic mutations and germline sequence variants in patients with familial colorectal cancer (2010) (33)
Risk of Osteopenia after Proctocolectomy and Ileal Pouch-Anal Anastomosis for Ulcerative Colitis (2002) (31)
Duodenal adenomatosis in familial adenomatous polyposis. DAF Project Group. (1995) (31)
Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma. (1992) (31)
Identification of 33 candidate oncogenes by screening for base-specific mutations (2014) (31)
Colorectal pretumor progression before and after loss of DNA mismatch repair. (2004) (31)
Smoking and insulin sensitivity in type I diabetic patients. (1986) (31)
Improvements in the treatment and prognosis of colorectal carcinoma (1988) (31)
Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation (2014) (31)
Quantitative Comparison of Growth-associated Protein-43 and Substance P in Ulcerative Colitis (2001) (31)
Cholesterol precursor sterols, plant sterols, and cholestanol in human bile and gallstones. (1986) (30)
Psychosocial consequences of predictive genetic testing for lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study (2013) (30)
Disease expression in juvenile polyposis syndrome: a retrospective survey on a cohort of 221 European patients and comparison with a literature-derived cohort of 473 SMAD4/BMPR1A pathogenic variant carriers (2020) (30)
Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study (2016) (30)
CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans (2013) (29)
Promoter‐specific alterations of APC are a rare cause for mutation‐negative familial adenomatous polyposis (2014) (29)
Risk of cancer in patients with chronic pouchitis after restorative proctocolectomy for ulcerative colitis (2011) (29)
Ethanol Stimulates Glycogenosis in Livers from Fed Rats (1992) (29)
Low-Penetrance Susceptibility Variants in Familial Colorectal Cancer (2010) (28)
Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles (2007) (28)
Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man (1991) (28)
Long-term results of restorative proctocolectomy for ulcerative colitis (2004) (28)
Action of insulin on glucose metabolism in vivo. (1993) (28)
Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online. (1998) (28)
DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas (2015) (28)
Anterior resection controls cancer of the rectum as well as abdominoperineal excision. (1995) (27)
A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis (2005) (27)
Acute and Chronic Effects of Hyperglycaemia on Glucose Metabolism: Implications for the Development of New Therapies (1997) (27)
Waist Circumference Adjusted for Body Mass Index and Intra-Abdominal Fat Mass (2012) (27)
Dissociation of in vitro sensitivities of glucose transport and antilipolysis to insulin in NIDDM. (1987) (27)
Experience with restorative proctocolectomy in 201 patients. (1993) (27)
Effects of Insulin on Blood Flow and Volume in Skeletal Muscle of Patients With IDDM: Studies Using [15O]H2O, [15O]CO, and Positron Emission Tomography (1997) (27)
Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins (2006) (27)
Changes in distribution of three isoforms of nitric oxide synthase in ulcerative colitis. (2001) (27)
MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. (2020) (27)
Uroepithelial and kidney carcinoma in Lynch syndrome (2012) (26)
The MDM 2 promoter polymorphism SNP 309 T R G and the risk of uterine leiomyosarcoma , colorectal cancer , and squamous cell carcinoma of the head and neck (2005) (26)
Genome‐wide association study and meta‐analysis in Northern European populations replicate multiple colorectal cancer risk loci (2017) (26)
Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients. (1992) (26)
Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene (1998) (26)
Pregnancy Proteins in the Endometrium after Follicle Aspiration for in Vitro Fertilization a (1985) (26)
EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis (2006) (25)
Metformin Prevents Weight Gain by Reducing Dietary Intake During Insulin Therapy in Patients with Type 2 Diabetes Mellitus (2012) (25)
Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus. (1999) (25)
Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue (2012) (25)
Causes of death of mutation carriers in Finnish Lynch syndrome families (2012) (25)
Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome (2017) (25)
Insulin therapy in type 2 diabetes: role of the long‐acting insulin glargine analogue (2004) (25)
Differential effects of oral and transdermal estradiol treatment on circulating estradiol fatty acid ester concentrations in postmenopausal women. (2003) (24)
Long-term results of continent ileostomy (2005) (24)
Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease. (2021) (24)
Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesity (2017) (24)
Results of sphincteroplasty in patients with spastic sphincter of Oddi. Predictive value of operative biliary manometry and provocation tests. (1986) (23)
Substance P- and vasoactive intestinal polypeptide-immunoreactive innervation in normal and inflamed pouches after restorative proctocolectomy for ulcerative colitis (1996) (23)
Systematic search for rare variants in Finnish early-onset colorectal cancer patients. (2015) (23)
No evidence for association of NOD2 R702W and G908R with colorectal cancer (2007) (23)
Response of adipose tissue lipoprotein lipase activity and serum lipoproteins to acute hyperinsulinaemia in man (1984) (23)
OSBP-Related Proteins (ORPs) in Human Adipose Depots and Cultured Adipocytes: Evidence for Impacts on the Adipocyte Phenotype (2012) (23)
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. (2012) (22)
Diabetes: Should we treat infection or inflammation to prevent T2DM? (2012) (22)
Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci (2011) (22)
A Strategy for Arterial Risk Assessment and Management in Type 2 (Non‐insulin‐dependent) Diabetes Mellitus (1997) (22)
LKB 1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome (2006) (22)
Substance P—An underlying factor for pouchitis? (1996) (22)
Influence of Ethnicity on the Accuracy of Non-Invasive Scores Predicting Non-Alcoholic Fatty Liver Disease (2016) (22)
Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes. (1999) (22)
Comparison of serial debulking and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei of appendiceal origin (2014) (22)
Does Preoperative Radiotherapy with Postoperative Chemotherapy Increase Acute Side-Effects and Postoperative Complications of Total Mesorectal Excision? Report of the Randomized Finnish Rectal Cancer Trial (2012) (21)
Insulin resistance due to hyperglycaemia: an adaptation protecting insulin-sensitive tissues (1997) (21)
Comparison of proctocolectomy and ileal pouch-anal anastomosis to colectomy and ileorectal anastomosis in familial adenomatous polyposis (2015) (21)
Insulin Sensitivity in Multiple Pathways Is Differently Affected During Zidovudine/Lamivudine-Containing Compared With NRTI-Sparing Combination Antiretroviral Therapy (2010) (21)
Concentrations of Insulin Glargine and Its Metabolites During Long-Term Insulin Therapy in Type 2 Diabetic Patients and Comparison of Effects of Insulin Glargine, Its Metabolites, IGF-I, and Human Insulin on Insulin and IGF-I Receptor Signaling (2013) (21)
Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease[S] (2010) (21)
Primary sclerosing cholangitis: outcome of patients undergoing restorative proctocolecetomy for ulcerative colitis (2009) (21)
Aspartylglycosaminuria (AGU). Further aspects on its clinical picture, mode of inheritance and epidemiology based on a series of 57 patients. (1973) (20)
Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD (2016) (20)
Novel splicing associations of hereditary colon cancer related DNA mismatch repair gene mutations (2004) (20)
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers. (2005) (20)
Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases (2003) (20)
Evidence for a primary role of insulin resistance in the pathogenesis of type 2 diabetes. (1990) (20)
Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle. (2000) (20)
Numbers of mutations to different types of colorectal cancer (2005) (20)
Desmoid disease as a part of familial adenomatous polyposis coli. (1987) (19)
Glucose tolerance, plasma lipoproteins and tissue lipoprotein lipase activities in body builders (2004) (19)
Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in Type 2 (non-insulin-dependent) diabetic patients (1993) (19)
Assay of glucose transport in human fat cells obtained by needle biopsy (1986) (19)
Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients (2003) (19)
Impact of short-term overfeeding of saturated or unsaturated fat or sugars on the gut microbiota in relation to liver fat in obese and overweight adults. (2020) (19)
Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei. (2016) (19)
Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans (2016) (19)
Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study (2017) (19)
MODY genes and mutations in hepatocyte nuclear factors (1997) (19)
Insulin binding and action in adipocytes in vitro in relation to insulin action in vivo in young and middle-aged subjects. (1986) (18)
Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease (2017) (18)
Marked resistance of the ability of insulin to decrease wave reflection in the aorta characterizes human obesity (1999) (18)
FAILURE TO SUPPRESS C‐PEPTIDE SECRETION BY EUGLYCAEMIC HYPERINSULINAEMIA: A NEW DIAGNOSTIC TEST FOR INSULINOMA? (1985) (18)
Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype (2013) (18)
The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription (2016) (18)
Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives (1994) (18)
No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer (2007) (18)
Serum total renin, an independent marker of the activity and severity of retinopathy in patients with IDDM (1998) (18)
Liver involvement and its course in patients operated on for ulcerative colitis. (1995) (17)
Measurement of lactate formation from glucose using [6-3H]- and [6-14C]glucose in humans. (1990) (17)
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues. (1997) (17)
ANTIBIOTICS IN ACUTE CHOLECYSTITIS (1975) (17)
Gastric carcinoid tumours and atrophic gastritis. (1987) (17)
Arterial stiffness and insulin resistance. (2002) (17)
Heterogeneity of non‐alcoholic fatty liver disease (2015) (17)
Comparison of Dorsocervical With Abdominal Subcutaneous Adipose Tissue in Patients With and Without Antiretroviral Therapy–Associated Lipodystrophy (2011) (17)
Nonglycemic effects of insulin. (2003) (17)
Type 2 diabetes: remission in just a week (2011) (17)
Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis (2016) (17)
Management of Type 2 Diabetes Mellitus and Cardiovascular Risk (2000) (16)
Ceramides: A Cause of Insulin Resistance in Nonalcoholic Fatty Liver Disease in Both Murine Models and Humans (2020) (16)
Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly (2012) (16)
ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer (2008) (16)
Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer. (2017) (16)
Glargine and Regular Human Insulin Similarly Acutely Enhance Endothelium-Dependent Vasodilatation in Normal Subjects (2004) (16)
Comparison of insulin regimens for patients with type 2 diabetes (2000) (15)
Effect of exercise on insulin binding and glucose transport in adipocytes of normal humans. (1987) (15)
Impact of non‐alcoholic fatty liver disease on liver volume in humans (2015) (15)
Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform (2004) (15)
Serum CA 242 and CEA detect different patients with recurrent colorectal cancer. (1996) (15)
PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper. (2002) (15)
Abnormal liver function tests in acute cholecystitis; the predicting of common duct stones. (1978) (15)
Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients (2013) (15)
In vivo glucose-stimulated amylin secretion is increased in nondiabetic patients with pancreatic cancer. (2001) (15)
Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei (2017) (15)
Evidence for spatial heterogeneity in insulin- and exercise-induced increases in glucose uptake: studies in normal subjects and patients with type 1 diabetes. (2001) (14)
Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease (2021) (14)
Mechanisms of altered hemodynamic and metabolic responses to insulin in patients with insulin-dependent diabetes mellitus and autonomic dysfunction. (1998) (14)
Effect of insulin treatment on serum lipoprotein(a) in non‐insulin‐dependent diabetes (1995) (14)
EXO 1 Variants Occur Commonly in Normal Population : Evidence against a Role in Hereditary Nonpolyposis Colorectal Cancer 1 (2002) (14)
Changes in muscle glucose metabolism in type 1 diabetes. (1990) (13)
Ileal Pouch–Anal Anastomosis, Conventional Ileostomy and Ileorectal Anastomosis Modify Cholesterol Metabolism (2004) (13)
Early experience with biofragmentable anastomosis ring in colon surgery. (1990) (13)
ACQUIRED OBESITY INCREASES CD68 AND TNF-α AND DECREASES ADIPONECTIN GENE EXPRESSION IN ADIPOSE TISSUE. A study in monozygotic twins. (2006) (13)
Uridine supplementation increases subcutaneous fat in patients with HAART-associated lipodystrophy: a randomized, placebo-controlled trial (2005) (13)
Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat. (1995) (13)
Biliary bacteremia at various stages of acute cholecystitis. (1980) (13)
Splenectomy for myelofibrosis. (1982) (13)
Increased concentrations of glycogen synthase protein in skeletal muscle of patients with NIDDM. (1995) (13)
The PNPLA3‐I148M variant increases polyunsaturated triglycerides in human adipose tissue (2020) (13)
Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease (2020) (12)
Cholescintigraphy in the diagnosis of acute cholecystitis. (1978) (12)
Restorative compared with conventional proctocolectomy for the treatment of ulcerative colitis. (1996) (12)
Hereditary cancer: guidelines in clinical practice. Colorectal cancer genetics. (2004) (12)
Exenatide twice-daily does not affect renal function or albuminuria compared to titrated insulin glargine in patients with type 2 diabetes mellitus: A post-hoc analysis of a 52-week randomised trial. (2019) (12)
Utility of computed tomographic colonography in surveillance for hereditary nonpolyposis colorectal cancer syndrome (2007) (12)
OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions (2020) (12)
Fatty liver score and 15-year incidence of type 2 diabetes (2013) (12)
Combination of the dipeptidyl peptidase-4 inhibitor linagliptin with insulin-based regimens in type 2 diabetes and chronic kidney disease (2015) (12)
Estimation of blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography data (1997) (12)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Efficacy and Safety of Linagliptin as Add-on Therapy to Basal Insulin in Patients With Type 2 Diabetes (2012) (11)
The PNPLA3-I148M variant confers an antiatherogenic lipid profile in insulin-resistant patients. (2020) (11)
The liver as a target for therapy in non-insuling dependent diabetes mellitus (1994) (11)
Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance. (2012) (11)
High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint. (2011) (11)
Mutation analysis of SMAD2,SMAD3, andSMAD4 genes in hereditary non-polyposis colorectal cancer (2000) (10)
Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes (2009) (10)
Retroperitoneal fibrosis of the pancreatic head mimicking carcinoma of the pancreas. (2001) (10)
Is There Evidence to Support Use of Premixed or Prandial Insulin Regimens in Insulin-Naive or Previously Insulin-Treated Type 2 Diabetic Patients? (2013) (10)
Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon Levels (2015) (10)
Mucosal alterations in pelvic ileal reservoirs. A histological and ultrastructural evaluation in an experimental model. (1988) (10)
Glutamine: fructose-6-phosphate amidotransferase activity and gene expression are regulated in a tissue-specific fashion in pregnant rats. (1999) (10)
insulin sensitivity in NAFLD associated with the E 167 K variant in TM 6 SF 2 (2017) (9)
Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance (2021) (9)
Less Nocturnal Hypoglycemia and Weight Gain with New Insulin Glargine 300 U/mL Compared with 100 U/mL: 1-Year Results in People with T2DM Using Basal Insulin with OADs (EDITION 2) (2014) (9)
One‐year response to evening insulin therapy in non‐insulin‐dependent diabetes (1992) (9)
Insulin resistance in type I diabetes: prevalence, pathogenesis and therapeutic approaches. (1984) (9)
Serum carcinoembryonic antigen and DNA ploidy in colorectal carcinoma. A prospective study. (1991) (9)
PSD3 downregulation confers protection against fatty liver disease (2022) (9)
Psychosocial adaptation to ileostomy: a study after construction of conventional and continent stomies. (1987) (9)
Congenital funnel anus. (1996) (8)
Diabetes, Liver Cancer, and Cirrhosis: What Next? (2018) (8)
Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation (2003) (8)
Multiple risk factor intervention in type 2 diabetes: an opportunity not to be missed (2001) (8)
Genome-Wide Association Analysis Confirms Importance of PNPLA3 and Identifies Novel Variants Associated With Histologically Progressive Steatohepatitis in NAFLD (2012) (8)
Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus (2021) (8)
Immunohistochemical demonstration of relaxin in gynecologic tumors (1983) (8)
Immunohistochemical demonstration of relaxin in the placenta after removal of the corpus luteum. (1984) (8)
Years of Insulin Therapy With Insulin Glargine Improves In Vivo Endothelial Function in Type 2 Diabetes (2004) (7)
Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD (2010) (7)
Endo-ultrasonography for preoperative staging of rectal cancer. (1988) (7)
New Insulin Glargine 300 U/mL: Glycemic Control and Hypoglycemia in a Meta-Analysis of Phase 3a EDITION Clinical Trials in People with T2DM (2014) (7)
Surgical repair of vulvar anus in adults (1989) (7)
Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity (2021) (7)
Development and Validation of a Score for Fibrotic Non-Alcoholic Steatohepatitis. (2022) (7)
Pathogenesis of nonalcoholic fatty liver disease (NAFLD) (2015) (7)
Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins (2021) (7)
Cholesterol metabolism and non-cholesterol sterols in patients with ileal pouch anastomosis. (1997) (7)
Efficacy and safety of linagliptin as add‐on therapy to basal insulin and metformin in people with Type 2 diabetes (2016) (7)
Sphincter-saving surgery for rectal carcinoma. Comparison of two five-year periods from 1980 to 1989. (1991) (6)
Tumours of the small intestine: Peutz-Jeghers syndrome (2000) (6)
Expression of Inducible and Endothelial Nitric Oxide Synthases in Pouchitis (2001) (6)
Diagnosis of nonalcoholic fatty liver disease (NAFLD). (2016) (6)
Management of fulminating ulcerative colitis. (1992) (6)
ADOPT: Lessons from Comparison of Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy (2007) (6)
Relationship between oral glucose tolerance and insulin sensitivity in healthy man and type 1 diabetic patients. (1986) (6)
Sustained Glycemic Control and Less Hypoglycemia with New Insulin Glargine 300 U/mL Compared with 100 U/mL: 1-Year Results in People with T2DM Using Basal + Mealtime Insulin (EDITION 1) (2014) (6)
Identification of cancer family syndrome. (1986) (6)
ADOPT: lessons from comparison of glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. (2007) (6)
Diabetes and Arterial Stiffness (2001) (6)
Ceramides Dissociate Steatosis and Insulin Resistance in the Human Liver in Non-Alcoholic Fatty Liver Disease. (2016) (6)
Solubilization and preliminary characterization of the human ileal vitamin B12-intrinsic factor receptor. (1979) (6)
Uppergastrointestinal tract polyps infamilial adenomatosis coli (1983) (6)
Surgical aspects of familial adenomatous polyposis (1988) (6)
Choledochoscopy versus postexploratory cholangiography in prevention of retained common duct stones. (1984) (5)
Three-year exenatide therapy, followed by a 4-week off-drug period, had a sustainable effect on β-cell disposition index in metformin treated patients with type 2 diabetes (2011) (5)
Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects. (2017) (5)
rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis (2020) (5)
No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man (1990) (5)
Natural course of NAFLD and type 2 diabetes in HIV-positive subjects with and without combination antiretroviral therapy (cART)-associated lipodystrophy: a 16-year follow-up study. (2019) (5)
Hepatic dearterialization in the treatment of carcinoid syndrome. (1987) (5)
Effects of Weighted Hula-Hooping Compared to Walking on Abdominal Fat, Trunk Muscularity, and Metabolic Parameters in Overweight Subjects: A Randomized Controlled Study (2019) (5)
Screening for hereditary colorectal carcinoma. (1989) (5)
Comparison of Acute Daytime and Nocturnal Insulinization on Diurnal Glucose Homeostasis in NIDDM (1994) (5)
Faecal lipids in familial adenomatosis coli. (1988) (5)
Cancer in ulcerative colitis: what failed in follow-up? (1985) (4)
Cholecystography, intravenous cholegraphy or ultrasonography in suspected acute cholecystitis. A controlled comparative study. (1980) (4)
Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease (2022) (4)
Glycodelin responses to hyperinsulinaemic clamp vary according to basal serum glycodelin concentration (2005) (4)
One Year Exenatide Therapy, Compared with Insulin Glargine, Reduces Postprandial Oxidative Stress in Metformin-Treated Patients with Type 2 Diabetes (2009) (4)
Beneficial Changes on Body Composition and Circulating Adiponectin and hsCRP Levels Following One Year of Exenatide Therapy, Compared with Insulin Glargine, in Metformin-Treated Patients with Type 2 Diabetes (2009) (4)
people with type 2 diabetes using basal plus mealtime insulin : the EDITION 1 12-month randomized trial , including 6-month extension (2015) (4)
[Diagnosis and treatment of Lynch syndrome]. (2016) (4)
No association between retinopathy and insulin resistance in type 1 diabetes. (1986) (4)
The treatment of acute cholecystitis. A series of 497 consecutive patients. (1979) (4)
Skeletal muscle mitochondrial DNA content and aerobic metabolism in patients with antiretroviral therapy-associated lipoatrophy. (2010) (4)
Restorative proctocolectomy for ulcerative colitis. (1988) (4)
Funnel anus and megacolon in an adult (1985) (4)
Oral antidiabetic drugs and GLP-1 analogues (2000) (3)
Changes in Anal Pressures and Function after Low Anterior Resection (1997) (3)
The occurrence of relaxin in hyperstimulated human preovulatory follicles collected in an in vitro fertilization program (1984) (3)
Extended, 3-year, exenatide therapy shows sustainable effects on beta cell disposition index in metformin treated patients with type 2 diabetes (2010) (3)
Diabetes mellitus and heart disease. (1999) (3)
Colo-anal sleeve resection for rectal hemangioma. Case report. (1989) (3)
rs641738C>T near MBOAT7 is positively associated with liver fat, ALT, and histological severity of NAFLD: a meta-analysis (2019) (3)
The Insulin Resistance Syndrome (2004) (3)
Newly diagnosed type 2 diabetes (2000) (3)
[Colonic carcinoma]. (2009) (3)
Other gastrointestinal polyps (2005) (3)
NR1H4 rs35724 G>C variant modulates liver damage in nonalcoholic fatty liver disease (2021) (3)
In vitro Effects of Bacterial Exposure on Secretion of Zonulin Family Peptides and Their Detection in Human Tissue Samples (2022) (3)
14th European Congress on Digital Pathology (2019) (3)
Pelvic ileal reservoirs: experimental assessment of reservoir capacity in three reservoir designs. (1987) (3)
Serum Insulin Bioassay Reflects Insulin Sensitivity and Requirements in Type 1 Diabetes (2017) (3)
Natural Course of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Patients With Human Immunodeficiency Virus With and Without Combination Antiretroviral Therapy–associated Lipodystrophy: A 16-Year Follow-up Study (2020) (3)
Premalignant conditions of the gastrointestinal tract: a basis for selective screening programs. (1989) (3)
Long-term outcome of patients after IPAA for ulcerative colitis (1998) (2)
Low Levels of Unmodified Insulin Glargine in Plasma of People With Type 2 Diabetes Requiring High Doses of Basal Insulin (2015) (2)
Insulin therapy in type 2 diabetes (2000) (2)
American Society of Colon and Rectal Surgeons 91st Annual Convention Podium and Poster abstracts (1992) (2)
[Screening for colon cancer]. (1994) (2)
Continuous grading of early fibrosis in nafld using label-free imaging (2016) (2)
Screening for gastrointestinal cancers in high-risk groups. (1989) (2)
Interposition mesocaval shunt for bleeding oesophageal varices in moderate and poor risk cirrhotics. (1981) (2)
A Simple Therapeutic Combination for Type 2 Diabetes (2000) (2)
Genetic variation in PNPLA 3 ( adiponutrin ) confers sensitivity to weight loss – induced decrease in liver fat in humans 1 – 3 (2011) (2)
Strategies to prevent hypoglycaemia during insulin therapy in Type 2 diabetes. (2002) (2)
[Intravenous cholegraphy in acute cholecystitis (author's transl)]. (1978) (2)
[Percutaneous transhepatic cholangiography in the diagnosis of jaundice]. (1982) (2)
Familial cancer. A review on hereditary cancer traits with special regard to colorectal carcinoma. (1988) (2)
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. (2023) (2)
A Review of its Therapeutic Use as a Long-Acting Agent for the Management of Type 1 and 2 Diabetes Mellitus (2001) (2)
3′-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity (2015) (2)
Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes (2022) (2)
Advances in Brief No Evidence of Peutz-Jeghers Syndrome Gene LKB 1 Involvement in Left-sided Colorectal Carcinomas 1 (2000) (2)
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) (2015) (2)
Corrigendum to: "Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort"☆ (J Hepatol [2020] 505-515). (2021) (2)
Heterogeneity of glucose metabolism at rest and during exercise in obesity as measured using [18F]-FDG and PET (2000) (2)
Strategies to prevent hypoglycaemia during insulin therapy in Type 2 diabetes. (2002) (2)
[Glucose toxicity--pros and cons. Useful adaptation and common cause of insulin resistance in diabetic patients]. (1996) (1)
Growth Patterns in Young Adult Monozygotic Twin Pairs Discordant and Concordant for Obesity (2004) (1)
Michaela Diamant, 11 April 1962–9 April 2014 (2014) (1)
Dietary Saturated Fats Increase And Plant Stanol Esters Decreases Ldl Aggregation (2019) (1)
New insulin glargine 300 U/mL: Glycemic control and hypoglycemia in a meta-analysis of EDITION clinical trials in people with T2DM (2015) (1)
Determination of a Normal value for HOMA-IR and cut-off Value for Non-Alcoholic Fatty Liver Disease (2016) (1)
A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. (1999) (1)
Aggressive angiomyxoma—report of three cases (2007) (1)
adenomatous polyposis (FAP) Guidelines for the clinical management of familial (2008) (1)
[Finnish registry for familial colonic adenomatosis]. (1984) (1)
[A familial cancer syndrome]. (1984) (1)
Surgical treatment of anal incontinence--a preliminary report. (1986) (1)
Local excision as an option in the treatment of low rectal carcinoma. (1997) (1)
Effect of overfeeding diets enriched with unsaturated or saturated fatty acids or sugars on de novo lipogenesis, lipolysis and liver fat in humans (2016) (1)
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases (2012) (1)
Exercise in the Treatment of Type 2 and 1 Diabetes (2008) (1)
LB-PO-860 COMPREHENSIVE METABOLOMIC CHARACTERISATION OF LIPOPROTEIN FRACTIONS REVEALS DIFFERENTIAL LIPOPROTEIN-SPECIFIC REGULATION OF XENOBIOTIC AND PRO-INFLAMMATORY METABOLITES IN PATIENTS WITH METABOLIC SYNDROME (2007) (1)
Endoscopic Surveillance in Hereditary Nonpolyposis Colorectal Cancer (2006) (1)
Anal spinchter reconstruction. Surgical results and functional outcome. (1990) (1)
Activity of Coagulation Factors IX and XIII and Fibrinogen are Increased in “Obese Non-Alcoholic Fatty Liver Disease” but not in “PNPLA3 Non-Alcoholic Fatty Liver Disease” (2016) (1)
Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue (2012) (1)
Plasma C-Peptide Concentration and Risk of Hypoglycemia in People with T2DM treated with Insulin Glagine 300 U/mL (Gla-300) or Insulin Glargine 100 U/mL (Gla-100) (2017) (1)
Abstract 5193: Novel candidate oncogenes with mutation hot spots in microsatellite unstable colorectal cancer (2014) (1)
Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study. (2023) (1)
[Single-stage proctocolectomy and ileo-anal anastomosis: benefits and risk factors]. (1993) (1)
[Blood transfusion and prognosis of colorectal canmcer]. (1989) (1)
New InsulinGlargine 300 Units / mL Versus Glargine 100 Units / mL in People With Type 2 Diabetes Using Oral Agents and Basal Insulin : Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (2014) (1)
Single-cell analysis of non-alcoholic fatty livers identifies a role for the constitutive androstane receptor (2022) (1)
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report (2017) (1)
Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects (2012) (1)
Abstract 4766: DNA methylation changes in Lynch syndrome associated colorectal adenomas and carcinomas (2015) (1)
One-year exenatide treatment improves beta cell response in metformin treated patients with type 2 diabetes which is sustained after 5 weeks discontinuation of treatment (2009) (1)
Duodesal surgery is only a temporary solution in familial adenomatous polyposis (2001) (0)
357 speaker EUROPEAN GUIDELINES – 2009 RECOMMENDATION BY EUROPEAN COMMISSION (2011) (0)
Diabetes: definition, differential diagnosis and classification (2000) (0)
Abstract 4491: Pseudoexons may underlie unbalanced expression of APC alleles in familial adenomatous polyposis (2016) (0)
Lipogenic Thrsp as a regulator of adipocyte metabolism (2021) (0)
[A serine/threonine kinase gene defective in Peutz-Jeghers syndrome]. (1998) (0)
[Early diagnosis and screening of colonic adenomatous polyposis]. (1991) (0)
[What should be the target of therapy in the adult-onset diabetes mellitus?]. (1999) (0)
INSULIN RESISTANCE: WHOLE BODY MECHANISMS IN HUMANS (2002) (0)
Blood pressure variability in diabetic autonomic neuropathy (1998) (0)
Hepatic insulin resistance is the basis of bile acid dysmetabolism in non-alcoholic fatty liver disease (2022) (0)
Abstracts of papers presented at the thirtieth Nordic Meeting of Gastroenterology, the twenty-first Nordic Meeting of Endoscopy and the ninth SAGIM Scientific Session, Oulu, Finland, 3-6, June 1998 (1998) (0)
Genetic Mapping ofa LocusPredisposing to HumanColorectal Cancer (2017) (0)
Uroepithelial and kidney carcinoma in Lynch syndrome (2012) (0)
Increased aromatase expression in human subcutaneous adipose tissue in obesity (2004) (0)
Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity (2023) (0)
Comparison of proctocolectomy and ileal pouch-anal anastomosis to colectomy and ileorectal anastomosis in familial adenomatous polyposis (2014) (0)
[How should patients with colorectal cancer be followed?]. (1992) (0)
The PNPLA3 I148M variant increases intrahepatic lipolysis and beta oxidation and decreases de novo lipogenesis and hepatic mitochondrial function in humans (2022) (0)
Validation of the blood test MACK-3 for the noninvasive diagnosis of fibrotic NASH: an international study with 1,924 patients. (2023) (0)
Ischaemic colitis--a clinical study of seven patients with special emphasis on diagnostic problems. (1991) (0)
Colorectal cancer incidence in path _ MLH 1 carriers subjected to different follow-up protocols (2017) (0)
A nine gene expression classifier predicts survival in stage II colon cancer based on microsatellite instability status (2005) (0)
Characterization of the genomic profile of pseudomyxoma peritonei using amplicon sequencing combined with exome sequencing (2016) (0)
Non-alcoholic fatty liver disease - studies on pathogenesis and diagnosis (2017) (0)
Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study. (2023) (0)
[Troglitazone, an insulin action enhancer--a drug of precision to treat adult-onset diabetes]. (1997) (0)
Abstract 2401: Identification of new target genes in microsatellite unstable colorectal cancer by exome sequencing (2014) (0)
Reply to Krahn and Sebastiani. (2020) (0)
Heterogeneity of phosphatidylcholine metabolism in non-alcoholic fatty liver disease (2022) (0)
[Prognosis and follow-up of colon and rectal carcinoma patients after surgical intervention]. (1988) (0)
Physiologic doses of insulin decrease central systolic blood pressure without changing peripheral vascular resistance in normal subjects (1999) (0)
Intravenous cholangiography and cholescintigraphy in the diagnosis of hepatobiliary disease. (1978) (0)
Abstract 3864: Low-penetrance variants underlying familial colorectal cancer (2010) (0)
Sustained glycemic control and less hypoglycemia with new insulin glargine 300 U/mL vs. 100 U/mL: 1-year results in T2DM with basal+mealtime insulin (EDITION 1) (2015) (0)
Abstract 3156: New candidate oncogenes discovered in microsatellite unstable colorectal cancer. (2013) (0)
Adiponutrin, a lipid droplet surface enzyme - evidence for regulation by ChREBP, SREBP1c and FXR in human hepatocytes (2010) (0)
[Treatment of pseudomyxoma peritonei is developing]. (2010) (0)
Metabolome in human hepatic vein and artery: Liver metabolite fluxes in a hepatic venous catheterization study in subjects with NAFLD (2010) (0)
Insulin therapy and cardiovascular risk. Introduction. (2003) (0)
Glucose Toxicity and Insulin Resistance in NIDDM (1997) (0)
Osteopenia in patients with pouchitis (2000) (0)
Discovery and validation of plasma markers of liver fat content: Metabolomics approach (2010) (0)
3′-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity (2015) (0)
EFFECTS OF 5-YEAR FENOFIBRATE TREATMENT ON ARTERIAL STIFFNESS AND CAROTID INTIMA-MEDIA THICKNESS IN TYPE 2 DIABETES: FIELD HELSINKI SUBSTUDY (2008) (0)
DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas (2015) (0)
Early detection of vascular disease in Type 2 Diabetes (2003) (0)
[Insulin dependent diabetes mellitus patients benefit from teaching programs]. (1996) (0)
Endothelial dysfunction and insulin resistance in men with small LDL particles (1999) (0)
Efficacy and Safety of Flexible Versus Fixed Dosing Intervals of Insulin Glargine 300 U / mL in People with Type 2 (0)
Retrospective study of indications for surgery in 218 patients affected by crohn's disease (2000) (0)
Why does non-alcoholic fatty liver disease (NAFLD) contribute to cardiovascular outcomes? (2016) (0)
[How does adult-type diabetes develop?]. (1990) (0)
Diabetic Angiopathy John E. Tooke (ed). London, UK: Arnold, 1999. No. of pages: 304. Price: £75.00 (HB). ISBN: 0 340 74102 3 (2001) (0)
Treatment and follow-up in type 2 diabetes (2000) (0)
P1075 : IGFBP-1 Significantly helps in predicting liver fat in NAFLD (2015) (0)
Insulin and exercise stimulated glucose uptake and its heterogeneity in subjects with type 1 diabetes. In vivo studies using [15O]-H2O, [15O]-O2, [18F]-FDG and PET (2000) (0)
An analogy of cobalamin membrane transport: an intestinal receptor for heme (1979) (0)
Core Project European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions (2020) (0)
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans 1 – 3 (2012) (0)
New insulin glargine 300U/ml in Type 2 diabetes using basal plus meal-time insulin: sustained glycaemic control and less hypoglycaemia compared with glargine 100U/ml (EDITION 1) (2015) (0)
Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study (2017) (0)
Gut microbiota and markers of metabolic endotoxemia in obese adults during short term hypercaloric intervention (2018) (0)
Reply: To PMID 24941021. (2015) (0)
[From animal models to human trials of Peutz-Jeghers syndrome]. (2004) (0)
Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease. (2023) (0)
Abstract 105: Characterizing the exomic profile of MSI colorectal cancer (2012) (0)
Response to Dr Braillon (2011) (0)
WO9-OR-4 POSTPRANDIAL LIPEMIA ASSOCIATES WITH LIVER FAT CONTENT (2007) (0)
Immunohistochemical Demonstration Gynecologic Tumors (1983) (0)
B25Insulin resIstance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle. Studies using 18FDG,H215o and positron emission tomography. (1995) (0)
SUPPLEMENTARY MATERIAL FOR: Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids (2019) (0)
Causes of death of mutation carriers in Finnish Lynch syndrome families (2012) (0)
Influence of sample collection and storage to the metabolic profile of blood (2011) (0)
WO2-OR-4 LIVER FAT INFLUENCES BOTH THE BASELINE PRODUCTION - AND THE ACUTE REGULATION OF VLDL1 TG AND APOB (2007) (0)
AXIN2, Tooth Agenesis, and Colorectal Cancer (2016) (0)
Carbohydrate restriction reverses NAFLD by altering hepatic mitochondrial fluxes in humans (2020) (0)
Genetics and colorectal cancer: basic science meets clinical practice. (1996) (0)
3614 POSTER HRQoL in Different Health States of Colorectal Cancer (2011) (0)
PO21-632 QUANTIFICATION OF LIVER FAT BY PROTON MAGNETIC RESONANCE SPECTROSCOPY IN 271 SUBJECTS WITH AND WITHOUT THE METABOLIC SYNDROME (2007) (0)
Corrigendum to: "Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆" [J Hepatol (2020) 505-515]. (2023) (0)
Macrophage scavenger receptor 1 mediates lipid-induced inflammation in human obesity-related non-alcoholic fatty liver disease (2020) (0)
Abstract 5018: Genetic and epigenetic investigation of breast carcinoma arising in Lynch syndrome families (2012) (0)
Genome-wide asociation study and meta-analysis in Northrn European populations replicate multiple colorectal cancer risk (2017) (0)
Interactions between diet, intestinal microflora and mucosal morphology in patients with ileal pouch-anal anastomosis (2001) (0)
Acquired Obesity Changes Adipose Tissue MRNA Expression, Increases Abdominal and Liver Fat, and Causes Insulin Resistance in Monozygotic Twins (2004) (0)
Colorectal surveillance in Lynch syndrome families (2013) (0)
Inflammatory markers in serum and adipose tissue in relation to markers of sub-clinical atherosclerosis in rheumatoid arthritis patients (2012) (0)
[Insulin treatment in NIDDM]. (1996) (0)
Abstract 2964: Histology-specific patterns of DNA methylation in Lynch-associated and sporadic ovarian cancer (2015) (0)
NOS-2 is induced in pouchitis (2000) (0)
The Liver as a Target for Therapy in NIDDM (1995) (0)
O27 DOES PNPLA3 INCREASE LIVER FAT BY EXTRA-HEPATIC MECHANISMS? (2014) (0)
Routine operative needle cholangiography in cholecystectomy for gallstones. A prospective study of 486 patients. (1984) (0)
Vascular effects of insulin (2000) (0)
Obesity Inhibition of Platelet-Collagen Interaction : An In Vivo Action of Insulin Abolished (2001) (0)
Evaluation of the substance-P and VIP-immunoreactive innervation in pouchitis (1995) (0)
Bone mineral density was not affected by exenatide therapy despite a significant reduction in body weight in patients with type 2 diabetes (2010) (0)
Non-insulin-dependent diabetes mellitus and cardiovascular risk (1999) (0)
Colorectal cancer (2000) (0)
Running head: Acquired poor fitness impairs gene expression (2008) (0)
Chapter 4 One-year exenatide and insulin glargine treatment improves prandial beta-cell response in metformin treated patients with type 2 diabetes (2011) (0)
O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ (2015) (0)
ATVB In Focus Metabolic Syndrome and Atherosclerosis (2007) (0)
Marked underestimation of liver fat content as measured by magnetic resonance versus histology—a systematic review and meta-analysis (2022) (0)
M.684 Central pressure augmentation and aortic systolic blood pressure are independently associated with intima-media thickness in type 2 diabetic patients (2004) (0)
[Why is there an impaired insulin action in a patient with diabetes?]. (1990) (0)
The quest for the missing links in fatty liver genetics: Deep learning to the rescue! (2022) (0)
Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes (2022) (0)
Abstract 417: DNA methylation changes in Lynch syndrome and FAP-associated colorectal tumorigenesis (2014) (0)
Linagliptin Proves Safe and Effective as Add-on Therapy to Basal Insulin (2012) (0)
Mapping transcriptional heterogeneity and metabolic networks in fatty livers at single-cell resolution (2022) (0)
Role of the fatty liver (NAFLD) in the pathogenesis and treatment of Type II Diabetes (2009) (0)
Endotoxemia induced insulin resistance is caused by a defect in GLUT 4 translocation. • 388 (1997) (0)
Disturbances in -Cell Function in Impaired Fasting (2002) (0)
Abstract A57: Nonsense‐mediated decay escaping mutations in microsatellite-unstable colorectal cancer (2009) (0)
OC.08.1 PROGRAMMED CELL DEATH 1 GENETIC VARIANT AND LIVER DAMAGE IN NONALCOHOLIC FATTY LIVER DISEASE (2023) (0)
[Cancer in ulcerative colitis: only the follow-up can detect cancer]. (1986) (0)
Allele-specifi c regulation of MTTP expression infl uences the risk of ischemic heart disease (2010) (0)
DETERMINATION OF A NORMALVALUE FOR HOMA-IR AND CUT-OFF VALUE FOR NON-ALCOHOLIC FATTY LIVER DISEASE (2017) (0)
The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles. (2022) (0)
related DNA mismatch repair gene Novel splicing associations of hereditary colon (2004) (0)
Lifestyle education in type 2 diabetes (2000) (0)
Effects of treatment of NAFLD on the metabolic syndrome (2016) (0)
[Treatment of hyperglycemia in adult-onset diabetes mellitus]. (1999) (0)
Psychosocial consequences of predictive genetic testing for lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study (2013) (0)
[Atrophic gastritis, pernicious anemia and gastric carcinoids]. (1990) (0)

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