Hanoch Senderowitz
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Israeli chemist
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Hanoch Senderowitzchemistry Degrees
Chemistry
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Organic Chemistry
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Chemistry
Why Is Hanoch Senderowitz Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hanoch Senderowitz is an Israeli chemist specializing in the fields of Computational Chemistry, Molecular modelling, Computer-Aided Drug Design, and Chemoinformatics. Biography Hanoch Senderowitz received his Ph.D. in 1993 from Tel Aviv University under the supervision of Prof. Benzion Fuchs. He then spent four years as a Post Doctorate Fulbright fellow at Columbia University, working with Prof. W. Clark Still. After returning to Israel in 1997, he joined the pharmaceutical industry, working first at Peptor Ltd. for six years and then at Epix Pharmaceuticals until 2008. In 2009, he joined Bar Ilan University as an associate professor at the Department of Chemistry leading the molecular modeling, computer-aided drug design and chemoinformatics lab.
Hanoch Senderowitz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis* (2010) (168)
- Materials Informatics (2019) (166)
- A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrates (1998) (135)
- Docking Studies on DNA Intercalators (2014) (125)
- A Smart Monte Carlo Technique for Free Energy Simulations of Multiconformational Molecules. Direct Calculations of the Conformational Populations of Organic Molecules (1995) (87)
- Carbohydrates: United Atom AMBER* Parameterization of Pyranoses and Simulations Yielding Anomeric Free Energies (1996) (70)
- Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. (2013) (61)
- Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins (2016) (60)
- Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator* (2012) (48)
- Synthesis, biological studies and molecular dynamics of new anticancer RGD-based peptide conjugates for targeted drug delivery. (2016) (42)
- Data Mining and Machine Learning Tools for Combinatorial Material Science of All‐Oxide Photovoltaic Cells (2015) (39)
- A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway. (2007) (38)
- Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold. (2014) (36)
- Diagnostic structural criteria for the anomeric effect in carbohydrates and inferences of general significance on their scope and limitations (1990) (34)
- Exploring the conformational space of cyclic peptides by a stochastic search method. (2004) (34)
- G Protein-Coupled Receptors: target-based in silico screening. (2009) (33)
- Dual‐drug RGD conjugates provide enhanced cytotoxicity to melanoma and non‐small lung cancer cells (2016) (33)
- Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study. (2013) (32)
- SeleX-CS: A New Consensus Scoring Algorithm for Hit Discovery and Lead Optimization (2009) (30)
- New supramolecular host systems. 2. 1,3,5,7-tetraoxadecalin, 1,2-dimethoxyethane and the Gauche effect reappraised. Theory vs. experiment. (1994) (30)
- G protein coupled receptors -in silico drug discovery and design. (2010) (29)
- Probing the Anomeric Effect in OCN Systems Theory vs. Experiment: MO-ab initio Calculations and a Structural-Statistical Analysis†‡ (1990) (26)
- Guaiacol as a drug candidate for treating adult polyglucosan body disease. (2018) (24)
- Toward Focusing Conformational Ensembles on Bioactive Conformations: A Molecular Mechanics/Quantum Mechanics Study (2015) (23)
- Computation of N-C-N systems: Theory vs. experiment (1992) (20)
- Computation of O-C-F and N-C-F systems : ab-initio calculations and a MM2 parameterization study. Theory vs. experiment (1993) (20)
- Combating Cystic Fibrosis: In Search for CF Transmembrane Conductance Regulator (CFTR) Modulators (2011) (20)
- Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy (2018) (19)
- RANdom SAmple Consensus (RANSAC) algorithm for material-informatics: application to photovoltaic solar cells (2017) (19)
- A bicyclic and hsst2 selective somatostatin analogue: design, synthesis, conformational analysis and binding. (2001) (18)
- Specific stabilization of CFTR by phosphatidylserine. (2017) (18)
- Modified MM2 scheme for computation of OCN‐containing systems (1993) (18)
- Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-Pα,α-Dithiophosphate Analogues. (2018) (17)
- A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS) (2015) (17)
- REMD Simulations Reveal the Dynamic Profile and Mechanism of Action of Deleterious, Rescuing, and Stabilizing Perturbations to NBD1 from CFTR (2015) (17)
- A reliable computational workflow for the selection of optimal screening libraries (2015) (17)
- k‐Nearest neighbors optimization‐based outlier removal (2015) (17)
- Potentiators exert distinct effects on human, murine, and Xenopus CFTR. (2016) (17)
- Activation of PPARδ: from computer modelling to biological effects (2015) (16)
- Optimization of Molecular Representativeness (2014) (16)
- Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity (2015) (16)
- Biasing conformational ensembles towards bioactive-like conformers for ligand-based drug design (2010) (16)
- The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue (2021) (16)
- Novel inhibitors of leukocyte transendothelial migration. (2019) (15)
- New supramolecular host systems. 1. A structural and conformational study of the 1,3,5,7-tetraoxadecalin core system (1994) (14)
- Hsp104 facilitates the endoplasmic‐reticulum–associated degradation of disease‐associated and aggregation‐prone substrates (2019) (14)
- Vimocin and Vidapin, Cyclic KTS Peptides, Are Dual Antagonists of α1β1/α2β1 Integrins with Antiangiogenic Activity (2014) (14)
- MC(JBW): Simple but smart Monte Carlo algorithm for free energy simulations of multiconformational molecules (1998) (14)
- STERIC AND STEREOELECTRONIC EFFECTS IN SATURATED HETEROCYCLES. I. SMALL MOLECULAR FRAGMENT CONSTITUENTS. THEORY VS. EXPERIMENT (1997) (14)
- Rescoring of docking poses under Occam’s Razor: are there simpler solutions? (2018) (13)
- Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1. (2018) (13)
- Materials Informatics: Statistical Modeling in Material Science (2016) (12)
- A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease. (2017) (12)
- Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage (2019) (11)
- Direct binding of salicylic acid to Pectobacterium N-acyl-homoserine lactone synthase. (2020) (11)
- Phloretin, an Apple Phytoalexin, Affects the Virulence and Fitness of Pectobacterium brasiliense by Interfering With Quorum-Sensing (2021) (10)
- Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site (2020) (10)
- An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters. (2019) (10)
- The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing (2018) (10)
- Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy. (2017) (9)
- Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator (2018) (9)
- RELATIVE STABILITIES AND CONFORMATIONAL RING INVERSION POTENTIALS IN HETEROCYCLIC DECALIN SYSTEMS AND STEREOELECTRONIC IMPLICATIONS (1996) (9)
- Bioactive Conformational Biasing: A New Method for Focusing Conformational Ensembles on Bioactive-Like Conformers (2009) (9)
- Quantitative structure–activity relationship analysis of β-amyloid aggregation inhibitors (2011) (8)
- Visualization Based Data Mining for Comparison Between Two Solar Cell Libraries (2016) (8)
- Structure and conformation of heterocycles. 21. Probing the anomeric effect in orthoesters. Structure, conformation, and dynamic behavior of a unique orthooxalate: 2,5,7,10,11,14-hexaoxa[4.4.4]propellane (1992) (8)
- PIXE based, Machine-Learning (PIXEL) supported workflow for glass fragments classification. (2021) (8)
- Interkingdom Signaling Interference: The Effect of Plant-Derived Small Molecules on Quorum Sensing in Plant-Pathogenic Bacteria. (2021) (7)
- Evaluation of QSAR Equations for Virtual Screening (2020) (7)
- A Multi-Objective Genetic Algorithm for Outlier Removal (2015) (7)
- Design of Compact Biomimetic Cellulose Binding Peptides as Carriers for Cellulose Catalytic Degradation. (2016) (7)
- Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold. (2019) (7)
- Carbohydrates: United Atom AMBER* Parameterization of Pyranoses and Simulations Yielding Anomeric Free Energies [J. Am. Chem. Soc. 1996, 118, 2078−2086]. (1996) (6)
- Stability Prediction for Mutations in the Cytosolic Domains of Cystic Fibrosis Transmembrane Conductance Regulator (2021) (6)
- Structure, conformation and stereoelectronics of 9,10-annelated-1,4,5,8-tetraoxadecalins: A multidisciplinary probe (1991) (6)
- Molecular Dynamics Flexible Fitting Simulations Identify New Models of the Closed State of the Cystic Fibrosis Transmembrane Conductance Regulator Protein. (2017) (6)
- Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model. (2018) (6)
- Molecular simulations for the evaluation of binding free energies in lead optimization (2011) (5)
- Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer. (2018) (5)
- Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma. (2017) (5)
- Anomeric Free Energy of d-Mannose in Water: A Comparison of Free Energy Perturbation, Potential of Mean Force, and MC(JBW)/SD Simulations (1997) (5)
- 2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor. (2014) (5)
- Sampling potential energy surface of glycyl glycine peptide: Comparison of Metropolis Monte Carlo and stochastic dynamics (1998) (5)
- Dynamic Classification for Materials‐Informatics: Mining the Solar Cell Space (2020) (4)
- Inter-laboratory workflow for forensic applications: Classification of car glass fragments. (2022) (4)
- Visualization of Solar Cell Library Space by Dimensionality Reduction Methods (2018) (4)
- Molecular Mechanics Calculations (2009) (4)
- Materials Informatics. (2018) (4)
- A Practical Method for Calculating Relative Free Energies of Binding. Chiral Recognition of Peptidic Ammonium Ions by Synthetic Ionophores (1997) (3)
- Photovoltaphores: pharmacophore models for identifying metal-free dyes for dye-sensitized solar cells (2022) (3)
- DESIGN OF STRUCTURAL COMBINATORIAL LIBRARIES THAT MIMIC BIOLOGIC MOTIFS* (2001) (3)
- Conformational energy and entropy differences of the t-butoxy group and implications in stereochemistry and stereoelectronics (1989) (3)
- Improving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria. (2019) (3)
- PV Analyzer: A Decision Support System for Photovoltaic Solar Cells Libraries (2018) (3)
- Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer. (2018) (2)
- Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions. (2018) (2)
- The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3 (2021) (2)
- Optimization Algorithms for Chemoinformatics and Material-informatics (2016) (1)
- Phenotypic and molecular characteristics of CF patients carrying the I1234V mutation. (2020) (1)
- Disintegrin-Based, Synthetic Cyclic KTS Peptides as Novel Dual Antagonists of α1β1/α2β1 Integrins with Antiangiogenic Activity (2016) (1)
- The Q359K/T360K mutation causes cystic fibrosis in Georgian Jews. (2018) (1)
- Peptide-based development of PKA activators (2018) (1)
- A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis‐causing mutation (2019) (1)
- A Comparison between Enrichment Optimization Algorithm (EOA)-Based and Docking-Based Virtual Screening (2021) (1)
- Structure and Conformation of Heterocycles. Part 20. Structure, Conformation and Stereoelectronics of 9,10-Anellated-1,4,5,8- tetraoxadecalins: A Multidisciplinary Probe (1991) (0)
- Thermodynamic correction of F 508 del-CFTR 1 Ligand binding to a remote site thermodynamically corrects the F 508 del mutation in the human cystic fibrosis transmembrane conductance regulator (2018) (0)
- Vimocin and Vidapin, cyclic KTS peptides, dual antagonists of 1 integrins with antiangiogenic activity (2014) (0)
- Computational, Drug Release and Biological Evaluation of Three New Anti- Cancer Cyclic RGD Peptide Conjugates (2014) (0)
- The spliced leader RNA silencing (SLS) pathway in Trypanosoma brucei is induced by perturbations of endoplasmic reticulum, Golgi, or mitochondrial proteins factors and functional analysis of SLS inducing kinase, PK3 (2021) (0)
- CFTR Potentiators Exert Different Effects on Human, Murine, and Xenopus CFTR (2016) (0)
- Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with 5-methyl-UTP (2018) (0)
- Designing a multiroute synthesis scheme in combinatorial chemistry. (2004) (0)
- Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model (2019) (0)
- Vimocin and Vidapin , Cyclic KTS Peptides , Are Dual Antagonists of a 1 b 1 / a 2 b 1 Integrins with Antiangiogenic Activity s (2014) (0)
- Structure and Conformation of Heterocycles. Part 24. Computation of O‐ C‐F and N‐C‐F Systems: ab‐initio Calculations and a MM2 Parameterization Study. Theory vs. Experiment (1993) (0)
- Experimental Determination of the Activation Parameters and Stereoselectivities of the Intramolecular Diels—Alder Reactions of 1,3,8‐Nonatriene, 1,3,9‐Decatriene, and 1,3,10‐Undecatriene and Transition State Modeling with the Monte Carlo‐Jumping Between Wells/Molecular Dynamics Method. (1998) (0)
- Toward Developing Techniques—Agnostic Machine Learning Classification Models for Forensically Relevant Glass Fragments (2022) (0)
- Structure and Conformation of Heterocycles. Part 26. New Supramolecular Host Systems. Part 2. 1,3,5,7-Tetraoxadecalin, 1,2- Dimethoxyethane and the Gauche Effect Reappraised. Theory vs. Experiment. (1995) (0)
- Inside Cover: Combating Cystic Fibrosis: In Search for CF Transmembrane Conductance Regulator (CFTR) Modulators / Second-Generation Iminoxylitol-Based Pharmacological Chaperones for the Treatment of Gaucher Disease (ChemMedChem 2/2011) (2011) (0)
- Combating Cystic Fibrosis: In Search of CF Transmembrane Conductance Regulator (CFTR) Modulators (2011) (0)
- Structure and Conformation of Heterocycles. Part 25. New Supramolecular Host Systems. Part 1. A Structural and Conformational Study of the 1,3,5,7‐Tetraoxadecalin Core System. (1995) (0)
- Front Cover: Computer‐Aided Design and Synthesis of 1‐{4‐[(3,4‐Dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic Acid as an Nrf2 Enhancer (ChemPlusChem 5/2018) (2018) (0)
- JPET #214643 1 Vimocin and Vidapin, cyclic KTS peptides, dual antagonists of α1β1/α2β1 integrins with anti- angiogenic activity (2014) (0)
- Steric and Stereoelectronic Effects in Saturated Heterocycles. Part 1. Small Molecular Fragment Constituents: Theory versus Experiment (1997) (0)
- Functional Stabilization of Purified Human CFTR by NBD1 Mutations and by Phosphatidylserine (2018) (0)
- WS4.2 Exploration of the ATP binding site in CFTR-NBD1 for enhanced ligand binding (2013) (0)
- 11th German Conference on Chemoinformatics (GCC 2015) (2016) (0)
- A comparison between 2D and 3D descriptors in QSAR modeling based on bio‐active conformations (2023) (0)
- Application of Materials Informatics Tools to the Analysis of Combinatorial Libraries of All Metal-Oxides Photovoltaic Cells (2019) (0)
- Towards an Enrichment Optimization Algorithm (EOA)‐based Target Specific Docking Functions for Virtual Screening (2022) (0)
- Crystal structure of nucleotide-binding domain 2 (NBD2) of the human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) (2020) (0)
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