Hans C. Clevers

Q: What Schools Are Affiliated With Hans C. Clevers

Hans C. Clevers is affiliated with the following schools: University of Lausanne, University of Amsterdam, University of Trento, Utrecht University, Baylor College of Medicine

Hans C. Clevers's AcademicInfluence.com Rankings

Hans C. Clevers

Biology

#981

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#1701

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Developmental Biology

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biology Degrees

Hans C. Clevers

Philosophy

#1116

World Rank

#2097

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Logic

#141

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#327

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philosophy Degrees

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Biology
Philosophy

Hans C. Clevers's Degrees

PhD Medicine Utrecht University

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Hans C. Clevers's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Single Lgr5 stem cells build cryptvillus structures in vitro without a mesenchymal niche (2009) (4974)
Identification of stem cells in small intestine and colon by marker gene Lgr5 (2007) (4898)
Wnt/β-Catenin Signaling and Disease (2012) (4428)
Wnt signalling in stem cells and cancer (2005) (3667)
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma (1997) (3456)
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC (1997) (3376)
Wnt/beta-catenin signaling in development and disease. (2006) (2910)
Wnt/β-Catenin Signaling in Development and Disease (2006) (2845)
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. (2011) (2522)
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017) (2487)
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts (2011) (2143)
Crypt stem cells as the cells-of-origin of intestinal cancer (2009) (2032)
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos (1996) (2021)
The cancer stem cell: premises, promises and challenges (2011) (1752)
Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells (2010) (1702)
Modeling Development and Disease with Organoids (2016) (1690)
A promoter-level mammalian expression atlas (2014) (1664)
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 (1998) (1656)
Linking Colorectal Cancer to Wnt Signaling (2000) (1577)
Cancer stem cells revisited (2017) (1577)
Caught up in a Wnt storm: Wnt signaling in cancer. (2003) (1567)
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients (2015) (1561)
Stem cells, self-renewal, and differentiation in the intestinal epithelium. (2009) (1519)
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. (2005) (1471)
Organoid Models of Human and Mouse Ductal Pancreatic Cancer (2015) (1403)
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells (2002) (1373)
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells (2005) (1331)
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. (2010) (1330)
Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF (1997) (1306)
The Human Cell Atlas (2017) (1285)
SARS-CoV-2 productively infects human gut enterocytes (2020) (1280)
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer (2017) (1240)
Coexistence of Quiescent and Active Adult Stem Cells in Mammals (2010) (1173)
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. (2013) (1156)
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling (2011) (1125)
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration (2013) (1123)
β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB (2002) (1107)
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors (2002) (1082)
Organoid Cultures Derived from Patients with Advanced Prostate Cancer (2014) (1074)
Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas (2012) (1056)
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. (2003) (1032)
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver (2015) (1022)
Notch1 functions as a tumor suppressor in mouse skin (2003) (1020)
Single-cell messenger RNA sequencing reveals rare intestinal cell types (2015) (996)
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. (2002) (975)
APC, Signal transduction and genetic instability in colorectal cancer (2001) (975)
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation (2012) (965)
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity (2018) (947)
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014) (940)
Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties (2013) (928)
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications (2013) (927)
The Intestinal Crypt, A Prototype Stem Cell Compartment (2013) (904)
Designer matrices for intestinal stem cell and organoid culture (2016) (890)
Lgr5 marks cycling, yet long-lived, hair follicle stem cells (2008) (883)
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer (2014) (860)
Organoids in cancer research (2018) (845)
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011) (832)
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. (2004) (802)
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex (2012) (791)
Sequential cancer mutations in cultured human intestinal stem cells (2015) (782)
A functional CFTR assay using primary cystic fibrosis intestinal organoids (2012) (781)
Drosophila Tcf and Groucho interact to repress Wingless signalling activity (1998) (778)
FoxM1 is required for execution of the mitotic programme and chromosome stability (2005) (771)
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors (2012) (760)
Mutations in the APC tumour suppressor gene cause chromosomal instability (2001) (755)
The T cell receptor/CD3 complex: a dynamic protein ensemble. (1988) (753)
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors (1998) (752)
Self-Renewal and Cancer of the Gut: Two Sides of a Coin (2005) (750)
De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine (2004) (730)
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin (2010) (728)
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers (2012) (704)
Single-cell dissection of transcriptional heterogeneity in human colon tumors (2011) (698)
Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005) (695)
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage (2012) (674)
Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate (2009) (665)
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF (1999) (649)
Tissue-specific mutation accumulation in human adult stem cells during life (2016) (645)
The intestinal stem cell. (2008) (640)
Wnt signalling induces maturation of Paneth cells in intestinal crypts (2005) (622)
The drug resistance-related protein LRP is the human major vault protein (1995) (620)
Isolation and in vitro expansion of human colonic stem cells (2011) (605)
Myc deletion rescues Apc deficiency in the small intestine (2007) (601)
Expression pattern of Wnt signaling components in the adult intestine. (2005) (586)
An HMG-box-containing T-cell factor required for thymocyte differentiation (1995) (568)
Signaling pathways in intestinal development and cancer. (2004) (566)
Specific inhibition of gene expression using a stably integrated, inducible small‐interfering‐RNA vector (2003) (559)
Paneth cells: maestros of the small intestinal crypts. (2013) (553)
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013) (553)
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (1999) (551)
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. (2012) (549)
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. (2018) (538)
Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures (2014) (538)
Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD (2004) (534)
Identification and cloning of TCF‐1, a T lymphocyte‐specific transcription factor containing a sequence‐specific HMG box. (1991) (532)
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis (1998) (530)
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell (2012) (525)
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. (2015) (524)
At the Crossroads of Inflammation and Cancer (2004) (524)
HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction (2009) (510)
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids (2018) (506)
Disease Modeling in Stem Cell-Derived 3D Organoid Systems. (2017) (504)
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength (2014) (499)
Wnt Signaling Controls the Phosphorylation Status of β-Catenin* (2002) (499)
Reparative inflammation takes charge of tissue regeneration (2016) (492)
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. (1999) (492)
The Intestinal Wnt/TCF Signature. (2007) (490)
Long‐term expanding human airway organoids for disease modeling (2019) (488)
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes (2004) (486)
Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. (1999) (484)
Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4 (1996) (476)
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. (2011) (467)
Transcriptome Profile of Human Colorectal Adenomas (2007) (465)
Interrogating open issues in cancer precision medicine with patient-derived xenografts (2017) (462)
Tales from the crypt: new insights into intestinal stem cells (2018) (459)
Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues (2011) (455)
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. (2009) (453)
Mining the Wnt pathway for cancer therapeutics (2006) (449)
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation (2016) (445)
The chromatin remodelling factor Brg‐1 interacts with β‐catenin to promote target gene activation (2001) (440)
Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging (2014) (438)
De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data (2016) (429)
Cancer modeling meets human organoid technology (2019) (427)
Mutational signature in colorectal cancer caused by genotoxic pks+E. coli (2020) (426)
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. (2016) (423)
EphB receptor activity suppresses colorectal cancer progression (2005) (423)
Differentiated Troy + Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium (2013) (420)
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny (2013) (416)
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis (2016) (414)
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2 (2008) (406)
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer (2015) (396)
CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. (1991) (393)
Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD (2003) (387)
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids (2018) (387)
All Tcf HMG box transcription factors interact with Groucho-related co-repressors. (2001) (386)
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche (2016) (384)
MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm (2003) (380)
Mining the Wnt pathway for cancer therapeutics (2007) (379)
Lrig1 controls intestinal stem cell homeostasis by negative regulation of ErbB signalling (2012) (378)
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity (2019) (377)
Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. (1998) (372)
Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse (1998) (365)
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. (2009) (361)
Sox‐4, an Sry‐like HMG box protein, is a transcriptional activator in lymphocytes. (1993) (360)
WNT signalling and haematopoiesis: a WNT–WNT situation (2005) (352)
Wnt signaling, lgr5, and stem cells in the intestine and skin. (2009) (351)
Intra-tumour diversification in colorectal cancer at the single-cell level (2018) (341)
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium (2011) (339)
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening. (2018) (338)
Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients (2019) (335)
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation (2013) (332)
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. (2004) (331)
Single-molecule transcript counting of stem-cell markers in the mouse intestine (2011) (330)
The Yin-Yang of TCF/beta-catenin signaling. (2000) (329)
Survivin and molecular pathogenesis of colorectal cancer (2003) (329)
Glial origin of mesenchymal stem cells in a tooth model system (2014) (327)
Tissue-resident adult stem cell populations of rapidly self-renewing organs. (2010) (327)
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. (2006) (324)
Ancestry and diversity of the HMG box superfamily. (1993) (322)
Origins of lymphatic and distant metastases in human colorectal cancer (2017) (319)
β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds (2002) (317)
Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells (2016) (316)
Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases (2015) (315)
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. (2011) (312)
TCF/LEF factor earn their wings. (1997) (308)
Wnt signals are transmitted through N‐terminally dephosphorylated β‐catenin (2002) (306)
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. (2010) (302)
TCF transcription factors: molecular switches in carcinogenesis. (1999) (300)
Genome sequencing of normal cells reveals developmental lineages and mutational processes (2014) (297)
Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture (2019) (291)
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer (2017) (291)
Organoid culture systems for prostate epithelial tissue and prostate cancer tissue (2016) (289)
Controlled gene expression in primary Lgr5 organoid cultures (2011) (285)
Organoids: Modeling Development and the Stem Cell Niche in a Dish. (2016) (284)
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis (2020) (281)
Identifying the stem cell of the intestinal crypt: strategies and pitfalls. (2012) (278)
Wnt control of stem cells and differentiation in the intestinal epithelium. (2005) (275)
Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer. (2019) (274)
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines (2010) (271)
Organoid cultures for the analysis of cancer phenotypes. (2014) (262)
Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis. (1993) (259)
Efficient Intracellular Delivery of Native Proteins (2015) (258)
Critical involvement of Tcf-1 in expansion of thymocytes. (1998) (257)
Catenins, Wnt signaling and cancer. (2000) (257)
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. (2010) (257)
The winged-helix transcription factor Trident is expressed in cycling cells. (1997) (255)
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. (2003) (252)
Modeling Cryptosporidium infection in human small intestinal and lung organoids (2018) (250)
Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc (2006) (246)
The Wnt/β-catenin pathway regulates cardiac valve formation (2003) (244)
The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-41 (2007) (244)
A rectal cancer organoid platform to study individual responses to chemoradiation (2019) (242)
The inner nuclear membrane protein Emerin regulates β‐catenin activity by restricting its accumulation in the nucleus (2006) (241)
The R-spondin protein family (2012) (241)
Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells (2008) (240)
Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development (2014) (239)
A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal (2012) (238)
Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria (2015) (236)
Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. (2000) (236)
Molecules relevant for T cell‐target cell interaction are present in cytolytic granules of human T lymphocytes (1989) (236)
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (2003) (235)
T‐cell factors: turn‐ons and turn‐offs (2002) (234)
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors (2016) (232)
Wnt signaling is required for thymocyte development and activates Tcf‐1 mediated transcription (2001) (229)
Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells (2012) (226)
Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location‐Specific Function (2014) (224)
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. (2009) (223)
Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells. (2017) (222)
Primary mouse small intestinal epithelial cell cultures. (2013) (221)
High-resolution 3D imaging of fixed and cleared organoids (2019) (221)
Tubuloids derived from human adult kidney and urine for personalized disease modeling (2019) (221)
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. (2009) (220)
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening (2019) (220)
Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties (1996) (220)
TCF: Lady Justice Casting the Final Verdict on the Outcome of Wnt Signalling (2002) (219)
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon (2016) (216)
The Wnt/beta-catenin pathway regulates cardiac valve formation. (2003) (216)
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. (2013) (216)
Regulation and plasticity of intestinal stem cells during homeostasis and regeneration (2016) (215)
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes (2011) (214)
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. (2015) (214)
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. (2012) (210)
Human Organoids: Tools for Understanding Biology and Treating Diseases. (2020) (209)
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. (2009) (209)
TCF transcription factors, mediators of Wnt-signaling in development and cancer. (2002) (208)
Wnt signaling mediates regional specification in the vertebrate face (2007) (207)
The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival (2001) (205)
Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand (2012) (202)
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion (2013) (202)
Distinct β-catenins mediate adhesion and signalling functions in C. elegans (2000) (202)
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ (2014) (201)
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. (2010) (199)
Sequence‐specific interaction of the HMG box proteins TCF‐1 and SRY occurs within the minor groove of a Watson‐Crick double helix. (1992) (199)
Xenograft and organoid model systems in cancer research (2019) (197)
Identification of a bovine surface antigen uniquely expressed on CD4−CD8− T cell receptor γ/δ+ T lymphocytes (1990) (197)
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. (2002) (196)
Establishment of patient-derived cancer organoids for drug-screening applications (2020) (196)
WNT signaling in the normal intestine and colorectal cancer. (2007) (196)
Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured “Miniguts” (2012) (195)
Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. (2002) (193)
Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man (1996) (193)
β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation (2003) (193)
Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling (2017) (190)
Human tissues in a dish: The research and ethical implications of organoid technology (2017) (190)
Crypt base columnar stem cells in small intestines of mice are radioresistant. (2012) (190)
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. (2008) (189)
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type (2013) (185)
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. (2010) (185)
Stem cells, asymmetric division and cancer (2005) (184)
Cell fate specification and differentiation in the adult mammalian intestine (2020) (184)
What does the concept of the stem cell niche really mean today? (2012) (182)
Adult mammalian stem cells: the role of Wnt, Lgr5 and R‐spondins (2012) (180)
Wnt, stem cells and cancer in the intestine (2005) (178)
Roles of Sox4 in central nervous system development. (2000) (177)
Differentiated human airway organoids to assess infectivity of emerging influenza virus (2018) (177)
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening (2016) (176)
Tracking adult stem cells (2011) (176)
Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids (2017) (176)
Premigratory and migratory neural crest cells are multipotent in vivo. (2015) (174)
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy. (2019) (173)
A Comprehensive Model of the Spatio-Temporal Stem Cell and Tissue Organisation in the Intestinal Crypt (2011) (172)
The kinase TNIK is an essential activator of Wnt target genes (2009) (170)
Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis. (2019) (170)
A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche. (2017) (170)
Live and let die in the intestinal epithelium. (2004) (168)
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling. (2001) (167)
Modeling pancreatic cancer with organoids. (2016) (166)
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. (2007) (165)
Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant. (2001) (165)
Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping (2019) (165)
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals (2015) (164)
Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time (2019) (163)
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. (2014) (162)
Organoids in immunological research (2019) (161)
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. (2005) (160)
EphB/EphrinB receptors and Wnt signaling in colorectal cancer. (2006) (160)
Tracking down the stem cells of the intestine: strategies to identify adult stem cells. (2007) (159)
Wnt‐induced transcriptional activation is exclusively mediated by TCF/LEF (2014) (159)
Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium. (1999) (159)
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. (2009) (158)
Adenomatous polyposis coli‐deficient zebrafish are susceptible to digestive tract neoplasia (2006) (157)
Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland (2012) (156)
Wnt breakers in colon cancer. (2004) (156)
Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis (2005) (156)
Molecular causes of colon cancer (2002) (154)
FANTOM5 CAGE profiles of human and mouse samples (2017) (153)
RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation (2016) (153)
Defining Adult Stem Cells by Function, not by Phenotype. (2018) (151)
Optimality in the Development of Intestinal Crypts (2012) (149)
Plasticity within stem cell hierarchies in mammalian epithelia. (2015) (148)
Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade (2009) (148)
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity (2020) (147)
WNT Signaling and Lymphocyte Development (2002) (147)
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer (2007) (147)
Stem cell self-renewal in intestinal crypt. (2011) (146)
Loss of syntaxin 3 causes variant microvillus inclusion disease. (2014) (146)
The many faces of the tumor suppressor gene APC. (2001) (144)
LGR5 positivity defines stem-like cells in colorectal cancer. (2014) (143)
Stem cell-derived organoids and their application for medical research and patient treatment (2017) (142)
Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident (1998) (141)
Lgr proteins in epithelial stem cell biology (2013) (141)
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. (2005) (140)
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE (2006) (140)
Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes. (1992) (140)
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient (2018) (139)
Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling. (2018) (138)
LKB1 tumor suppressor protein: PARtaker in cell polarity. (2004) (138)
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation (2012) (137)
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. (2002) (137)
Stem cells marked by the R-spondin receptor LGR5. (2014) (137)
Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition (2014) (137)
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia (2015) (136)
Mouse and human urothelial cancer organoids: A tool for bladder cancer research (2019) (135)
The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors). (2009) (135)
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor (1999) (134)
Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs. (2000) (134)
Armadillo/β-catenin signals in the nucleus – proof beyond a reasonable doubt? (2003) (133)
Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers (1991) (132)
Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche (2018) (131)
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. (2010) (129)
Wnt signaling, stem cells, and cancer of the gastrointestinal tract. (2012) (128)
From gut homeostasis to cancer. (2006) (128)
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele (2014) (127)
Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos (2004) (126)
Tissue-specific designs of stem cell hierarchies (2016) (125)
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models (2017) (125)
Cyclin D1 Is Not an Immediate Target of β-Catenin following Apc Loss in the Intestine* (2005) (125)
What is an adult stem cell? (2015) (124)
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids (2019) (123)
Comparative Proteomics of Colon Cancer Stem Cells and Differentiated Tumor Cells Identifies BIRC6 as a Potential Therapeutic Target* (2011) (123)
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling (2017) (122)
The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. (2005) (122)
Profiling proliferative cells and their progeny in damaged murine hearts (2018) (121)
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells. (2008) (121)
Fasting-mimicking diet and hormone therapy induce breast cancer regression (2020) (121)
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype (2016) (120)
A Genome-Wide Screen for Spatially Restricted Expression Patterns Identifies Transcription Factors That Regulate Glial Development (2009) (120)
Wnt Activates the Tak1/Nemo-like Kinase Pathway* (2004) (120)
The Rac Activator Tiam1 Is a Wnt-responsive Gene That Modifies Intestinal Tumor Development* (2006) (120)
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing (2020) (117)
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. (2001) (115)
Stem cells and cancer of the stomach and intestine (2010) (115)
Generation of L Cells in Mouse and Human Small Intestine Organoids (2014) (115)
Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. (2017) (115)
Lineage-dependent spatial and functional organization of the mammalian enteric nervous system (2017) (115)
c-Myb is required for progenitor cell homeostasis in colonic crypts (2007) (114)
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation (2020) (114)
Sox4-deficiency syndrome in mice is an animal model for common trunk. (1998) (114)
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors (2010) (113)
The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. (1997) (113)
Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling (2014) (112)
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer. (2009) (112)
Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells (2013) (112)
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy (2018) (111)
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids. (2019) (110)
Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. (2020) (110)
SnapShot: Growing Organoids from Stem Cells (2015) (109)
Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. (2000) (108)
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells (2020) (108)
Expression of GATA-3 During Lymphocyte Differentiation and Mouse Embryogenesis (1992) (108)
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice (2009) (107)
Transcriptional control of lymphoid development: lessons from gene targeting. (1996) (107)
Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori. (2015) (106)
Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis. (2019) (106)
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation (2016) (106)
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. (2010) (105)
Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses. (2019) (105)
Organoid culture systems to study host–pathogen interactions (2017) (105)
Use and application of 3D-organoid technology. (2018) (104)
Leukocyte‐associated immunoglobulin‐like receptor‐1 (LAIR‐1) is differentially expressed during human B cell differentiation and inhibits B cell receptor‐mediated signaling (1999) (103)
A20 controls intestinal homeostasis through cell-specific activities (2014) (103)
Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1. (1999) (102)
Wnt/β-catenin signaling in adult mammalian epithelial stem cells. (2017) (102)
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank. (2020) (102)
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. (1999) (102)
Sox‐4 facilitates thymocyte differentiation (1997) (102)
Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium. (2014) (101)
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis (2010) (101)
TCF and Groucho-related genes influence pituitary growth and development. (2003) (100)
CRISPR/Cas 9 genome editing and its applications in organoids. (2017) (100)
Members of the novel WC1 gene family are differentially expressed on subsets of bovine CD4-CD8- gamma delta T lymphocytes. (1994) (99)
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus (2013) (99)
Imaging organoids: a bright future ahead (2018) (98)
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential (2018) (98)
Rap2A links intestinal cell polarity to brush border formation (2012) (98)
Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells (2015) (97)
The BMP Antagonist Follistatin-Like 1 Is Required for Skeletal and Lung Organogenesis (2011) (96)
Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. (1987) (95)
Active Wnt signaling in response to cardiac injury (2010) (95)
Cdx2 determines the fate of postnatal intestinal endoderm (2012) (95)
Translational applications of adult stem cell-derived organoids (2017) (94)
BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance (2017) (92)
Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures. (2018) (92)
Robust Cre-Mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus (2014) (91)
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls (2013) (91)
On the biomechanics of stem cell niche formation in the gut – modelling growing organoids (2012) (91)
Wnt signaling in the thymus. (2003) (91)
Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early Xenopus development (1998) (90)
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan. (2011) (89)
Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels (2017) (89)
Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors (2020) (88)
LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (87)
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages (2020) (86)
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. (2013) (85)
An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance (2019) (84)
A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta (2013) (84)
Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids. (2019) (84)
Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells (2014) (84)
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. (2013) (84)
The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis (2010) (84)
Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine. (2020) (83)
Colon cancer--understanding how NSAIDs work. (2006) (83)
Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients. (2017) (83)
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution. (2021) (82)
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2 (2014) (82)
Transcriptional Control of T Lymphocyte Differentiation (2001) (80)
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. (2010) (80)
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions (2010) (80)
The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas (2012) (79)
Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells. (1999) (79)
Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance. (2020) (79)
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. (2021) (78)
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. (2019) (78)
Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis (2015) (78)
Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy. (1994) (77)
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations (2017) (76)
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer (2021) (76)
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells (2020) (76)
Automated brightfield morphometry of 3D organoid populations by OrganoSeg (2018) (75)
Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine. (2013) (75)
Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways. (2014) (74)
Live and let die in the intestinal epithelium (2003) (74)
Tcf/Lef transcription factors during T-cell development: unique and overlapping functions. (2000) (73)
Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering? (2017) (73)
Large-scale identification of coregulated enhancer networks in the adult human brain. (2014) (73)
Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes (2011) (72)
Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis (2017) (72)
Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids. (2019) (71)
Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt? (2003) (70)
T‐cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine (2007) (70)
Identification of a clonally expanding haematopoietic compartment in bone marrow (2012) (70)
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells (2019) (70)
Preclinical models of pancreatic ductal adenocarcinoma (2015) (69)
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma (2016) (69)
Solution Structure of the Sequence-specific HMG Box of the Lymphocyte Transcriptional Activator Sox-4 (*) (1995) (69)
Redundant functions of TCF‐1 and LEF‐1 during T and NK cell development, but unique role of TCF‐1 for Ly49 NK cell receptor acquisition (2003) (69)
Generation of BAC Transgenic Epithelial Organoids (2013) (69)
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids (2015) (69)
Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies. (2019) (68)
Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells (2019) (67)
What Is Your Conceptual Definition of "Cell Type" in the Context of a Mature Organism? (2017) (66)
Mutations of the hereditary hemochromatosis candidate gene HLA-H in porphyria cutanea tarda. (1997) (66)
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation. (2018) (66)
Analysis of neural crest–derived clones reveals novel aspects of facial development (2016) (65)
KLF5 regulates the integrity and oncogenicity of intestinal stem cells. (2014) (65)
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish (2011) (65)
Interplay between VHL/HIF1α and Wnt/β-catenin pathways during colorectal tumorigenesis (2006) (64)
Intestinal Regeneration: Regulation by the Microenvironment. (2020) (64)
Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields (2012) (64)
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations. (2019) (64)
Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins. (2018) (64)
CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids. (2020) (63)
Stem Cells: A unifying theory for the crypt (2013) (63)
Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency. (2014) (62)
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors (2019) (62)
An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking (2015) (62)
The Organoid Cell Atlas (2020) (62)
decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm. (2000) (61)
Goblet Cells Contribute to Ocular Surface Immune Tolerance—Implications for Dry Eye Disease (2017) (61)
Model organoids provide new research opportunities for ductal pancreatic cancer (2016) (60)
The Unusual Case of Porcupine (2012) (60)
Suppression of Tubulin Polymerization by the LKB1-Microtubule-associated Protein/Microtubule Affinity-regulating Kinase Signaling* (2007) (60)
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies (2020) (59)
Axin and hepatocellular carcinomas (2000) (59)
Cell differentiation by interaction of two HMG‐box proteins: Mat1‐Mc activates M cell‐specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites (1997) (59)
Investigation of Frizzled‐5 during embryonic neural development in mouse (2008) (59)
Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling (2013) (58)
Transcription factors in early T-cell development. (1993) (57)
HMG box containing transcription factors in lymphocyte differentiation. (1998) (57)
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. (2020) (57)
Stem Cells in Repair of Gastrointestinal Epithelia. (2017) (57)
Highly sensitive proteome analysis of FACS-sorted adult colon stem cells. (2011) (57)
Development and application of human adult stem or progenitor cell organoids (2015) (57)
Lysosomal Membrane Glycoproteins in Platelets (1992) (56)
Lineage tracing in the intestinal epithelium. (2010) (56)
Snake Venom Gland Organoids (2020) (56)
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. (2011) (56)
The Human Cell Atlas White Paper (2018) (55)
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids (2020) (55)
Intestinal organoid cocultures with microbes (2021) (55)
Conversion of metaplastic Barrett’s epithelium into post-mitotic goblet cells by γ-secretase inhibition (2010) (55)
T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation. (2019) (54)
COVID-19: organoids go viral (2020) (53)
Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer. (2021) (53)
Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells (2017) (53)
Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function (2018) (52)
Adult mammalian stem cells: the role of Wnt, Lgr5 and R‐spondins (2012) (52)
The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes. (1997) (52)
Synergistic action of A23187 and phorbol ester on human B cell activation. (1985) (52)
Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. (2006) (51)
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer (2019) (51)
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids (2021) (51)
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice (2018) (51)
ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling (2018) (51)
Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis (2000) (50)
Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy (2019) (50)
Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7. (2007) (50)
Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles (2010) (50)
Organoids and organs-on-chips: Insights into human gut-microbe interactions. (2021) (50)
The Epithelial Cellular Adhesion Molecule (EP-Cam) Is a Ligand for the Leukocyte-Associated Immunoglobulin-like Receptor (Lair) (2001) (49)
High expression of the HMG box factor sox-13 in arterial walls during embryonic development. (1998) (49)
The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint (2004) (49)
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure (2016) (49)
Identification of primary MAFB target genes in multiple myeloma. (2009) (49)
Targeting development of incretin-producing cells increases insulin secretion. (2015) (49)
TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers. (1991) (48)
A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis (2019) (48)
SnapShot: The Intestinal Crypt (2013) (48)
Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata (1990) (48)
Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors. (2015) (47)
A gene family of HMG-box transcription factors with homology to TCF-1. (1992) (47)
Defective iron homeostasis in β2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man (1997) (47)
Tumor environment: a potent driving force in colorectal cancer? (2001) (47)
Identification of two novel regulated serines in the N terminus of beta-catenin. (2002) (47)
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (1992) (47)
A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues (2019) (46)
Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected* (2004) (46)
Organoid biobanking: identifying the ethics (2016) (46)
The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators. (2022) (46)
Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1. (2000) (46)
WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer (2017) (46)
Transcriptional Regulation of CD4 Gene Expression by T Cell Factor-1/β-Catenin Pathway (2006) (46)
Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements. (1987) (46)
Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva. (1995) (46)
Airway organoids as models of human disease (2020) (45)
Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver (2020) (45)
Identification of a bovine surface antigen uniquely expressed on CD4-CD8- T cell receptor gamma/delta+ T lymphocytes. (1990) (44)
Paneth cells (2014) (44)
Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion (2019) (44)
An enhancer located in a CpG‐island 3′ to the TCR/CD3‐epsilon gene confers T lymphocyte‐specificity to its promoter. (1989) (43)
Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice. (1998) (42)
Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures (2017) (42)
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines. (1999) (42)
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency (2002) (42)
Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology. (2018) (42)
Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor–Positive Breast Cancer (2020) (42)
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures (2019) (42)
Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells (2020) (41)
Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research (2016) (41)
The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. (1995) (40)
A novel multi-gene family of sheep gamma delta T cells. (1994) (40)
Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter. (1988) (39)
Slide preparation for single-cell–resolution imaging of fluorescent proteins in their three-dimensional near-native environment (2011) (39)
Organoid Models for Cancer Research (2019) (39)
The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system (2015) (38)
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium (2010) (38)
Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. (2003) (38)
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice (2019) (37)
Cloning of murine TCF-1, a T cell-specific trans cription factor interacting with functional motifs in the CD3ε and T cell receptor α enhancers. (1991) (37)
Peutz–Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment (2007) (37)
Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein. (2002) (37)
Selectively impaired development of intestinal T cell receptor γδ+ cells and liver CD4+ NK1+ T cell receptor αβ+ cells in T cell factor‐1‐deficient mice (1996) (37)
Single-cell Ribo-seq reveals cell cycle-dependent translational pausing (2021) (36)
MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms. (2017) (36)
Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses (2019) (36)
Kidney Organoids and Tubuloids (2020) (36)
Immunosurveillance against tetraploidization-induced colon tumorigenesis (2013) (35)
ME491 melanoma-associated glycoprotein family: antigenic identity of ME491, NKI/C-3, neuroglandular antigen (NGA), and CD63 proteins. (1992) (35)
SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells (2017) (35)
AU-rich elements and alternative splicing in the β-catenin 3′UTR can influence the human β-catenin mRNA stability (2006) (35)
Exploring the human lacrimal gland using organoids and single-cell sequencing. (2021) (35)
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses (2021) (35)
Ectopic activation of lymphoid high mobility group‐box transcription factor TCF‐1 and overexpression in colorectal cancer cells (1997) (35)
Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools. (2007) (35)
Transcriptional control during T-cell development. (1998) (34)
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles (2020) (34)
In Situ Hybridization to Identify Gut Stem Cells. (2015) (33)
A common ancestor of the mammalian transcription factors TCF‐1 and TCF‐1α/LEF‐1 expressed in chicken T cells (1992) (33)
Single-cell derived tumor organoids display diversity in HLA class I peptide presentation (2020) (33)
Clustering of monoclonal antibodies recognizing different members of the WC1 gene family. (1993) (33)
Concise review: The Yin and Yang of intestinal (cancer) stem cells and their progenitors (2013) (33)
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids (2021) (33)
MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway (2010) (33)
Retroviral gene expression control in primary organoid cultures. (2013) (32)
Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype (2021) (32)
Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant (2018) (32)
Advancing lung organoids for COVID-19 research (2021) (32)
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins (2016) (31)
The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein. (1993) (31)
Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development (2015) (31)
Tissue-Engineering the Intestine: The Trials before the Trials. (2019) (31)
Wnt Signaling: Ig-Norrin the Dogma (2004) (31)
Mathematical model of colorectal cancer initiation (2020) (31)
Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease (2020) (30)
Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage (2004) (30)
Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. (2014) (29)
LKB 1 and AMPK Family Signaling : The Intimate Link Between Cell Polarity and Energy Metabolism (2009) (29)
Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations. (2019) (29)
Sox9 marks adult organ progenitors (2010) (28)
LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice (2013) (28)
Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity. (2017) (28)
Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors. (1999) (28)
SARS-CoV-2 infection and replication in human gastric organoids (2021) (28)
Wnt / β-catenin signaling regulates the expression of the homeobox gene Cdx 1 in embryonic intestine (27)
Bioengineered bile ducts recapitulate key cholangiocyte functions (2018) (27)
Towards a molecular understanding of T-cell differentiation. (1991) (27)
Promises and Challenges of Organoid-Guided Precision Medicine. (2021) (27)
Summary β-Catenin regulates Cripto-and Wnt 3-dependent gene expression programs in mouse axis and mesoderm formation (26)
In situ hybridization to identify gut stem cells. (2010) (26)
Repairing organs: lessons from intestine and liver. (2015) (26)
Enteroendocrine Dynamics – New Tools Reveal Hormonal Plasticity in the Gut (2020) (26)
Translation and Replication Dynamics of Single RNA Viruses (2020) (26)
Eyeing Up New Wnt Pathway Players (2009) (26)
Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease (2020) (26)
Erratum: Interrogating open issues in cancer medicine with patient-derived xenografts (2017) (26)
AU-rich elements and alternative splicing in the beta-catenin 3'UTR can influence the human beta-catenin mRNA stability. (2006) (26)
Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium (2016) (26)
Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses (2020) (26)
Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma (2021) (25)
Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes (2017) (25)
Retromer Dependent Recycling of the Wnt Secretion Factor Wls Is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium (2013) (25)
A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing (2020) (25)
Organoids: Avatars for Personalized Medicine. (2019) (25)
Patient-derived micro-organospheres enable clinical precision oncology. (2022) (24)
How the COVID-19 pandemic highlights the necessity of animal research (2020) (24)
T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis. (2009) (24)
Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. (2005) (24)
Sox 15, a novel member of the murine Sox family of HMG box transcription factors. (1993) (24)
The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes (1995) (24)
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip (2021) (24)
Characterization and expression of the murine CD3-epsilon gene. (1988) (23)
Tissue regeneration: Reserve or reverse? (2021) (23)
STRAD pseudokinases regulate axogenesis and LKB1 stability (2014) (23)
Ovarian LGR5 is critical for successful pregnancy (2014) (23)
Allogeneic bone marrow transplantation can restore CD4+ T-lymphocyte count and immune function in idiopathic CD4+ T-lymphocytopenia. (1996) (23)
Searching for adult stem cells in the intestine (2009) (23)
CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids. (2016) (23)
Lgr4 Controls Specialization of Female Gonads in Mice1 (2015) (22)
Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish. (2009) (22)
The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1 (1998) (22)
Establishment and characterization of a canine keratinocyte organoid culture system (2018) (22)
In vitro expansion and transplantation of intestinal crypt stem cells. (2012) (21)
Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma (2019) (21)
HMG box proteins in early T-cell differentiation. (1993) (21)
EphB receptor activity suppresses colorectal cancer progression (vol 435, pg 1126, 2005) (2005) (20)
LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate. (2020) (20)
LEF1 turns over a new leaf (2001) (20)
Inflammatory bowel disease, stress, and the endoplasmic reticulum. (2009) (20)
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors (2022) (20)
Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo (2017) (20)
The Generation of Organoids for Studying Wnt Signaling. (2016) (19)
Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance. (2020) (19)
dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila. (2000) (19)
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19 (2021) (19)
The murine Sox-4 protein is encoded on a single exon. (1993) (19)
Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney (2017) (19)
The sequence-specific high mobility group 1 box of TCF-1 adopts a predominantly alpha-helical conformation in solution. (1993) (19)
Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions (2020) (19)
An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth (2015) (18)
Intestinal Regeneration: YAP—Tumor Suppressor and Oncoprotein? (2013) (18)
Mycobacteria–host interactions in human bronchiolar airway organoids (2020) (18)
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. (2016) (18)
Establishment of Pancreatic Organoids from Normal Tissue and Tumors (2020) (18)
Leucine-rich Repeat-containing G-protein-coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells during Mouse Embryonic Development* (2014) (18)
Transcription Factor Target Practice (2006) (18)
Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease (2021) (17)
The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA. (1995) (17)
Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting dysbiosis that contribute to carcinogenesis. (2021) (17)
BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states. (2022) (17)
MafB oncoprotein detected by immunohistochemistry as a highly sensitive and specific marker for the prognostic unfavorable t(14;20) (q32;q12) in multiple myeloma patients (2009) (17)
Long-term expanding human airway organoids for disease modelling (2018) (17)
Calcium Ionophore A23187 Induces Interleukin 2 Reactivity in Human T Cells (1985) (17)
Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice. (1995) (16)
The Sox-13 gene: structure, promoter characterization, and chromosomal localization. (1999) (16)
A method for cDNA cloning in COS cells irrespective of subcellular site of expression. (1991) (16)
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells (2020) (16)
The frontier of live tissue imaging across space and time. (2021) (16)
Polarizing intestinal epithelial cells electrically through Ror2 (2014) (16)
Human-Derived Model Systems in Gynecological Cancer Research. (2020) (16)
How the Gut Feels, Smells, and Talks (2017) (16)
In vivo mucosal uptake, mucosal transfer and retention of iron in mice (1997) (16)
Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids. (2021) (15)
A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium (2021) (15)
Wheat germ agglutinin activates human T lymphocytes by stimulation of phosphoinositide hydrolysis. (1986) (15)
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis (2021) (14)
Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia (2020) (14)
Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF. (1998) (14)
Animal models of congenital defects in the ventriculoarterial connection of the heart (1997) (13)
Modulating WNT receptor turnover for tissue repair (2012) (13)
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation (2022) (13)
Modelling of primary ciliary dyskinesia using patient‐derived airway organoids (2021) (13)
Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies (2020) (13)
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss (2020) (13)
Uncovering the mode of action of engineered T cells in patient cancer organoids (2022) (13)
Inflating cell numbers by Wnt. (2002) (12)
Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7 (2021) (12)
Method for estimating the single molecular affinity. (2012) (12)
Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias. (2012) (12)
Inactivation of TGFb receptors in stem cells drives cutaneous squamous cell carcinoma (2016) (12)
Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism (2021) (12)
SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival. (2020) (12)
Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids (2020) (11)
Cancer therapy: Defining stemness (2016) (11)
Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan Theileria parva. (1997) (11)
Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation (2020) (11)
Ligands of Surface Ig Raise Cytoplasmic Free Ca++ in Human B Cells (1985) (11)
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant (2022) (11)
Conversion of Mature Human b-Cells Into Glucagon- Producing a-Cells (2013) (11)
Derivation of snake venom gland organoids for in vitro venom production (2021) (10)
Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma. (2021) (10)
Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations. (2015) (10)
IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2. (2017) (10)
MET signaling overcomes EGFR inhibition in normal and colorectal cancer stem cells causing drug resistance. (2019) (10)
Dll 1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage (2013) (10)
Author response: The Human Cell Atlas (2017) (10)
In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed (2022) (9)
Regulation of Lineage Commitment during Lymphocyte Development (2001) (9)
KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition (2021) (9)
Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries (2021) (9)
Replacement of Lost Lgr 5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage (2016) (9)
Evaluating CRISPR-based Prime Editing for cancer modeling and CFTR repair in intestinal organoids (2020) (9)
Cloning, sequencing and expression of the bovine CD3ε and TCR-ζ chains, two invariant components of the T-cell receptor complex (1996) (8)
Patient‐Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy (2022) (8)
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing (2020) (8)
Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties. (2022) (8)
Modelling Cryptosporidium infection in human small intestinal and lung organoids (2018) (8)
Primary Intestinal Epithelial Organoid Culture. (2020) (8)
Erratum: Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells (2017) (8)
Loss of Tcf7 diminishes hematopoietic stem/progenitor cell function (2013) (8)
Armadillo takes the APC shuttle (2000) (8)
Heterodimeric complex formation with CD8 and TCR by bispecific antibody sustains paracrine IL-2-dependent growth of CD3+ CD8+ T cells. (1992) (7)
Molecular characterization of Barrett’s esophagus at single-cell resolution (2021) (7)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (7)
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene (2022) (7)
P5-04-03: Personalized Cancer Treatment Selection Using Computational Signaling Pathway Models. (2011) (7)
Expanding intestinal stem cells in culture (2015) (7)
The transmembrane orientation of the ϵ chain of the TcR/CD3 complex (1988) (7)
Signaling mucins in the (S)limelight. (2004) (7)
Conference on Cadherins, Catenins and Cancer (2005) (7)
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis. (2023) (7)
Linking Colorectal Cancer to Wnt Signaling Review (2000) (7)
HB4 antibody recognizes a carbohydrate structure on lymphocyte surface proteins related to HB6, CDw75, and CD76 antigens. (1993) (7)
Modelling cancer immunomodulation using epithelial organoid cultures (2018) (7)
CRISPR-Induced TMPRSS2-ERG Gene Fusions in Mouse Prostate Organoids. (2017) (7)
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity (2019) (7)
The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies (2019) (7)
Medium-Throughput Drug- and Radiotherapy Screening Assay using Patient-Derived Organoids. (2021) (6)
Corrigendum: Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors (2017) (6)
Evidence generation and reproducibility in cell and gene therapy research: A call to action (2021) (6)
Thoughts on the thymus and the T-lymphocyte repertoire. Relevance to the tolerance of the immune response. (1993) (6)
ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation. (2020) (6)
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma (2021) (6)
Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology (2021) (6)
An assay for the identification of antigens recognized by cytotoxic T cells, based on transient transfection of COS cells. (1995) (6)
Functional analysis of Peutz-Jeghers mutations reveals that the LKB 1 carboxy-terminal region exerts a crucial role in regulating both the AMPK pathway and cell polarity (2005) (6)
Disease modelling following organoid-based expansion of airway epithelial cells. (2021) (6)
Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells (2014) (6)
The Paneth cell, caloric restriction, and intestinal integrity. (2012) (6)
Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology (2021) (6)
Organoid Studies in COVID-19 Research (2022) (6)
Beyond growth signaling: Paneth cells metabolically support ISCs (2017) (5)
Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma (2021) (5)
Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits (2022) (5)
Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumourigenesis in murine mammary epithelium (2016) (5)
Author response: Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening (2016) (4)
Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells (2017) (4)
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model (2021) (4)
The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy (2020) (4)
Genomic organization of the segment polarity gene pan in Drosophila melanogaster (1998) (4)
Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model. (2021) (4)
Ileal Crohn's Disease Is Linked to Wnt/Tcf-4 -Defensin Deficiency of a The Paneth Cell (2007) (4)
Abstract DDT01-01: BI 905677: A first-in-class LRP5/6 antagonist targeting Wnt-driven proliferation and immune escape (2019) (4)
Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression (2020) (4)
Erratum: How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030)) (2020) (4)
A gutsy approach to stem cells and signalling: an interview with Hans Clevers (2013) (4)
Neural stem cells for diabetes cell-based therapy (2011) (4)
Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding. (2016) (4)
Abstract 4294: Differentiated colorectal cancer cells protect tumor-initiating cells from irinotecan (2010) (3)
Adult mammalian stem cells : the role of Wnt , Lgr 5 and R-spondins Since (2013) (3)
A rectal cancer model establishes a platform to study individual responses to chemoradiation (2019) (3)
Disease modelling following organoid-based expansion of airway epithelial cells (2020) (3)
Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids (2017) (3)
Stem Cells and Tissue Renewal (2015) (3)
Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis (2020) (3)
Cloning, sequencing and expression of the bovine CD3 epsilon and TCR-zeta chains, two invariant components of the T-cell receptor complex. (1996) (3)
Author Correction: Establishment of patient-derived cancer organoids for drug-screening applications (2021) (3)
Rapid tissue prototyping with micro-organospheres (2022) (3)
Human liver organoids for disease modeling of fibrolamellar carcinoma (2022) (3)
differentiation , and migration Loss of Apc in vivo immediately perturbs Wnt signaling , Material (2004) (3)
Erratum: Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells (Stem Cell Reports (2014) 2 (838-852)) (2014) (3)
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models (2018) (3)
Studying cancer drug resistance using BRCA-deficient mouse mammary tumor organoids (2017) (3)
Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids (2017) (3)
Clinical evidence for an association between familial adenomatous polyposis and type II diabetes (2012) (2)
Wnts as self-renewal factors: mammary stem cells and beyond. (2010) (2)
Everything has its time: Id2 clocks embryonic specification of Lgr5+ gut stem cells (2017) (2)
Tubuloids derived from human adult kidney and urine for personalized disease modeling (2019) (2)
Cystic fibrosis patient-derived bronchial organoids unveil druggable pathways against Mycobacterium abscessus infection (2022) (2)
Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies (2018) (2)
IFN-γ: The T cell’s license to kill stem cells in the inflamed intestine (2019) (2)
Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumors (2022) (2)
A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology (2020) (2)
Abstract LB-40: Induciblein vivosilencing of Brd4 identifies potential toxicities of sustained BET protein inhibition (2014) (2)
Lgr5 Stem Cells in Self-Renewal and Cancer (2014) (2)
Human airway organoids model SARS-CoV-2 high infectiousness and evasion of interferon response (2020) (2)
Retinoic Acid-Induced Stellate Cell Quiescence Results in Sfrp4 Secretion Which Abrogates Wnt-β-Catenin Signalling Pathway Modulating Human Pancreatic Tumour Cell Behaviour (2011) (2)
Sequence-specific HMG box factors recognize 10- 12 base pair minor groove motifs (2000) (2)
Analysis of CD2 and TCR-beta gene expression in Jurkat cell mutants suggests a cis regulation of gene transcription. (1995) (2)
Correction: Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia (2020) (2)
How the COVID-19 pandemic highlights the necessity of animal research (2020) (2)
Intra-tumor diversification in colorectal cancer at the single-cell level. (2018) (2)
Oncogene-inducible organoids as a miniature platform to assess cancer characteristics (2017) (2)
Patient‐derived tumor organoids predict responses to irinotecan‐based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer (2022) (2)
Identification of stem cells in small intestine and colon by a single marker gene Lgr5 (2008) (2)
Human CD 3e gene contains three miniexons and is transcribed from a non-TATA promoter ( miniexons / alternative splicing / pulsed-field electrophoresis / CD 3 locus ) (2)
Nucleotidic sequences of bovine alpha and beta T cell antigen receptor cDNA clones (1989) (2)
Holehearted: genetic approaches to congenital cardiac valve malformations (2004) (2)
Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models (2022) (2)
Abstract IA6: Lgr5 stem cell-based organoids in human disease (2017) (1)
Lgr5 Stem Cell‐based organoids in human disease (2016) (1)
Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease (2021) (1)
On Stem Cells, Organoids and Human Disease (2019) (1)
Intestinal Organoid Swelling And Relation With Disease Severity And Response To Therapy (2016) (1)
VHL is a target of WNT signaling and may regulate the angiogenic switch in colorectal carcinoma (2005) (1)
Cloning and characterization of hELD / OSA 1 , a novel BRG 1 interacting protein (1)
Induction of different human enteroendocrine cells in intestinal organoids (2020) (1)
Author response: Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma (2021) (1)
Abstract IA1: Lgr5 stem cells in self-renewal and cancer (2013) (1)
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification (2021) (1)
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids (2022) (1)
ROCKin' Intestinal Cell Fate: A Potential Avenue to Improve Glucose Sensitivity. (2018) (1)
PS2-048. A20/TNFAIP3 in intestinal homeostasis and inflammation (2011) (1)
The Intestinal Stem Cell Compartment is the Initial Target of T Cell Invasion in GI Gvhd (2018) (1)
RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis (2021) (1)
Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids (2021) (1)
Hemochromatosis: β2-microglobulin-deficient mice as a model for hemochromatosis (2000) (1)
Urothelial organoids : a novel culture method for bladder cancer (2017) (1)
Canine Pituitary Organoids as 3D In Vitro Model for Cushing Disease (2021) (1)
Competitive Inhibitors of Ras Effector Binding (2019) (1)
Abstract 3674: Active Wnt Signaling in Cardiac Response to Injury (2009) (1)
Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription. (2021) (1)
LGR5 Mediates Positive B-Cell Selection and is Critical for Survival of Normal and Transformed B Cells (2018) (1)
Four-dimensional hydrogel-in-hydrogel bioprinting for the spatiotemporal control of organoid and organotypic cultures (2021) (1)
Abstract IA12: Lgr5 stem cell-based organoids in human disease (2016) (1)
Abstract 1173: A novel high throughput platform for head & neck cancer organoids drug screening (2019) (1)
Head and neck squamous cell carcinoma organoids as a platform for personalized medicine. (2018) (1)
CRISPR engineering in organoids for gene repair and disease modelling (2023) (1)
European Immunologists meet in Amsterdam. (1997) (1)
Giving APCmin tumours a SPARC (2007) (1)
Thymocyte development: drama without Brahma. (2003) (1)
LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (1)
Frizzled7 Functions as aWnt Receptor in Intestinal Epithelial Lgr5 StemCells (2015) (1)
A20/TNFAIP3 as a brake on intestinal inflammation and tumorigenesis (2014) (1)
Cancer stem cells: where do they come from and where are they going? (2021) (1)
Putative myeloma precursor cells expressing 2,6 sialic acid-modified antigens actually belong to the erythroid lineage. (1998) (1)
Stem Cell‐Derived Liver Cells (2020) (1)
Edinburgh Research Explorer Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo (2017) (1)
Abstract B16: Using human patient-derived organoids to identify genetic dependencies in pancreatic cancer (2016) (1)
Gut Microbiota in Colorectal Cancer: Associations, Mechanisms, and Clinical Approaches (2021) (1)
Structural and Genetic Aspects of the T Cell Receptor–T3 Complex (1986) (1)
Corrigendum: EphB receptor activity suppresses colorectal cancer progression (2005) (1)
The Myofibroblasts' War on Drugs. (2018) (1)
Tumor and Stem Cell Biology KLF 5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells (2014) (1)
National Heart, Lung and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration. (2021) (1)
Targeted inhibition of Wnt signaling with a bacterial toxin fragment suppresses breast cancer tumor-initiating/chemo-resistant cells (2020) (1)
Paecilomycone Inhibits Quorum Sensing in Gram-Negative Bacteria (2022) (1)
Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney: A Phylogenetic, Ontogenetic and Cell Dynamic Perspective. (2021) (1)
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient (2018) (1)
Patient-Derived Organoids (PDO) As the Potential Model to Predict Treatment Outcome of Rectal Cancer Patients Underwent Neo-Adjuvant Chemoradiotherapy (2019) (1)
Human stem cells for organs-on-chips: “clinical trials” without patients? (2021) (1)
A path to translation: How 3D patient tumor avatars enable next generation precision oncology. (2022) (1)
A transgenic mouse model for “lipid hang-up”, or why pathologists need to be involved in genetically engineered mouse modelling (2008) (1)
STRAD pseudokinases regulate axogenesis and LKB1 stability (2014) (1)
Retraction (2003) (1)
Erratum: Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc" (Molecular and cellular biology (2006) 26 22 (8418-8426) PII: e00482-18) (2018) (1)
Novel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids (2019) (1)
Cytotoxic T Cells Functions as an Inhibitory Receptor on Leukocyte-Associated Ig-Like Receptor-1 (1999) (0)
Irradiation dose response curves of organoids: data for Patient-derived organoids predict chemoradiation responses of locally advanced rectal cancer (2019) (0)
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation (2022) (0)
Characterization and expression of the murine CD 3E gene ( T-cell receptors for antigen / CD 3 gene family / T-celi-specific regulatory elements ) (0)
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids (2019) (0)
Establishment of human primary hepatocellular carcinoma-derived organoid cultures for disease modeling and drug screening (2018) (0)
Abstract IA27: Patient-derived organoids in pediatric cancer research (2020) (0)
Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver (2020) (0)
Adult stem cells: generation of self-organizing mini-organs in a dish (2021) (0)
BASIC—ALIMENTARY TRACT Prominin-1/CD133 Marks Stem Cells and Early Progenitors in Mouse Small Intestine (2009) (0)
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus (2013) (0)
High-resolution 3D imaging of fixed and cleared organoids (2019) (0)
Running Title: In vitro platform for Lcell studies (2013) (0)
Gut stem cells and tissue renewal (2022) (0)
Structure of the ectodomain of LGR5 in complex with R-spondin-1 ( Fu1Fu2) in P22121 crystal form (2013) (0)
Stem cells for discovery of effective and safe new drugs (2021) (0)
WS04-5 The TOPAZ study, a large-scale study in organoids derived from F508del homozygous cystic fibrosis patients treated with Orkambi (2019) (0)
Adult Intestinal Homeostatic Self-Renewal A Critical Role for the Wnt Effector Tcf 4 in (2012) (0)
The Organoid Cell Atlas (2020) (0)
Organoid Models of Neuroendocrine Cell Growth and Tumorigenesis (2020) (0)
IN PRESS ndian Hedgehog Regulates Intestinal Stem Cell Fate Through pithelial Mesenchymal Interactions During Development (2010) (0)
Frizzled7Functionsas aWntReceptorinIntestinalEpithelial Lgr5 + StemCells (2015) (0)
Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids. (2023) (0)
Description of a new bovine multigene family encoding for markers of differentiation of gamma/delta T-cells (1992) (0)
Use of transfection technology to identify antigens recognized by cytotoxic T lymphocytes from cattle immune to #Theileria parva# infection (1992) (0)
Abstract 4515: Lgr5 mediates positive B-cell selection and is critical for initiation and survival of B-cell malignancies (2018) (0)
Pseudokinases Regulate Axogenesis and LKB 1 Stability (2015) (0)
Physical mapping of bovine Major Histocompatibility Complex (1992) (0)
Sa1089: PKS+ E. COLI STATUS IN STOOL AS RISK MARKER FOR IMPROVING COLORECTAL CANCER EARLY DETECTION (2022) (0)
expression table of the human CAGE peaks (2017) (0)
Crystal structure of R-spondin 1 (Fu1Fu2) - Holmium soak (2013) (0)
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids (2020) (0)
Embryonic development (2021) (0)
Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids (2016) (0)
P610 Wnt AND NOTCH REGULATE PROLIFERATION, MIGRATION AND DIFFERENTIATION OF HUMAN HEPATIC PROGENITOR CELLS AND CANINE LIVER ORGANOIDS (2014) (0)
genomic coordinates of the human CAGE peaks (2017) (0)
Perspective Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions (2020) (0)
Mutations in BAP1 drive tumour sensitivity to programmed cell death in patient-derived cholangiocarcinoma orgnaoids (2022) (0)
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis (2020) (0)
Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes (2022) (0)
PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer (2017) (0)
Germline mutations in LKB 1 cause the rare cancer prone disorder (2005) (0)
Tumor-Driving Signal Transduction Pathways Knowledge-Based Computational Models That Identify Selection of Personalized Patient Therapy through the Use of (2014) (0)
Regeneration of Damaged Colonic Tissue by Transplantation of Colonic Epithelial Stem Cells Maintained and Expanded In Vitro (2011) (0)
Generation of Adult Stem Cell Derived Organoid Cultures From Thyroid Follicular Cells (2021) (0)
24 Stratification for cystic fibrosis (CF) disease severity in adults with CF with homozygous F508del mutations by intestinal organoids (2016) (0)
The Lgr5 positive intestinal stem cell signature (2012) (0)
antibodies. Cells were depleted of membrane cholesterol by treatment with 10 mM methyl-b-cyclodextrin (Sigma) in Dulbecco's modified Eagle's medium supplemented (2000) (0)
Stem cell-derived organoids and their application for medical research and patient treatment (2017) (0)
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity (2020) (0)
Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation (2022) (0)
SHORT REPORT Polarizing intestinal epithelial cells electrically through Ror2 (2014) (0)
Controlling the diversity of cell populations in a stem cell culture (2015) (0)
Aberrant activation of the WNT signaling pathway promotes proliferation in multiple myeloma (2005) (0)
[Physical mapping of the major histocompatibility complex of cattle]. (1992) (0)
Abstract PL02-02: Lgr5 ctem cells in self-renewal and cancer (2012) (0)
Novel deletion in a patient with an isolated peroxisoml acyl-CoA oxidase deficiency (1994) (0)
Intra-tumour diversification in colorectal cancer at the single-cell level (2018) (0)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (0)
Assembly of the T Cell Receptor/CD3 Complex (1989) (0)
genomic coordinates of the mouse CAGE peaks (2017) (0)
Drosophila Wnt/Wingless Signaling in (2012) (0)
Workshops (2012) (0)
Et in Arcadia Ego: Addressing Cancer, Death and Immortality Using Science (2017) (0)
Abstract PL01-04: Wnt signaling, Lgr5 stem cells, and cancer. (2013) (0)
Early invasion of uropathogenic Escherichia coli into the bladder wall by solitary bacteria that are protected from antibiotics and neutrophil swarms in an organoid model (2020) (0)
Evaluation of Wnt targets during intestinal development and carcinogenesis (2005) (0)
Automated brightfield morphometry of 3D organoid populations by OrganoSeg (2018) (0)
Abstract 5023: Stem cell hypothesis and function of Lgr5 in the development of colon cancer. (2013) (0)
Correction for Muncan et al., “Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc” (2018) (0)
TRMOME 1222 No . of Pages 18 Feature Review Disease Modeling in Stem Cell-Derived 3 D Organoid Systems (2017) (0)
The interaction of beta-catenin, TCF-4, and APC leading to the prevention of cancer (1998) (0)
Of mice and men: the history of embryonic stem cells (2021) (0)
assay information of the mouse qualitycontrol samples for HeliScopeCAGE (2017) (0)
Abstract KN01: Wnt signaling, Lgr5 stem cells, and cancer. (2013) (0)
Knockout Mice 2-Microglobulin β Erythropoiesis, Iron Deficiency, and Iron Loading in Adaptive Response of Iron Absorption to Anemia, Increased (2013) (0)
Development of novel metastatic prostate cancer cell lines by “organoid” in vitro culture technology. (2014) (0)
HMG box transcription factors in lymphocyte differentiation (1998) (0)
Expanding Impact of Stem Cell Science (2018) (0)
PO-271 Using human lung organoids to study pulmonary neuroendocrine cells (2018) (0)
Notum inhibits local Wnt signalling to increase the competitiveness of Apc -mutant clones (2021) (0)
Inactivation of transforming growth factor-beta receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis. (2016) (0)
Abstract 307: KSR1-dependent modulation of the translational landscape in Ras-driven colorectal cancer (2020) (0)
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant (2022) (0)
Generation of human knock-in organoids by CRISPR-HOT (2020) (0)
Activation of the Wnt cascade results in inhibition of the constitutive activity of GSK - (2002) (0)
Niche-independent high-purity cultures of Lgr5[superscript +] intestinal stem cells and their progeny (2013) (0)
InducedQuiescence of Lgr 5 + StemCells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells Graphical (2016) (0)
Human tissue with adult stem cell properties derived from pluripotent stem cells. (2014) (0)
A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids (2016) (0)
Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumors (2021) (0)
Abstract 1506: Frequent loss of function mutations in TGFβR1 and TGFβR2 identify hair follicle bulge stem cells as the cell of origin for cutaneous squamous cell carcinoma (2015) (0)
Nanoblades allow high-level genome editing in organoids (2022) (0)
23 Stratifying young children with cystic fibrosis for disease severity using intestinal organoid swelling, intestinal current measurements or sweat chloride concentration as CFTR-dependent biomarker (2016) (0)
The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures (2023) (0)
Drug Repurposing Screen on Patient-Derived Organoids Identifies New Therapeutic Drug Combination Against KRAS Mutant Colon Cancer (2021) (0)
Adaptive Response of Iron Absorption to Anemia, Increased Erythropoiesis, Iron Deﬁciency, and Iron Loading in (cid:98) 2-Microglobulin Knockout Mice (1998) (0)
The 5th Japan and US Collaboration Conference in Gastroenterology (2011) (0)
Faculty Opinions recommendation of A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. (2005) (0)
Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis (2017) (0)
A novelmulti-gene family ofsheep yi Tcells (1994) (0)
EP1118 Patient-derived ovarian cancer organoids resemble clinical response to chemotherapeutics and provide insights into response mechanisms (2019) (0)
711: Live imaging of cellular signaling in patient-derived tumor organoids (2014) (0)
Abstract 3905: Human liver organoids for disease modeling of fibrolamellar hepatocellular carcinoma (2020) (0)
Title Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways (2014) (0)
Following cell type transitions in space and time by combining live-cell tracking and endpoint cell identity in intestinal organoids (2022) (0)
Decision letter: Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19 (2021) (0)
Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies (2020) (0)
Patents, opportunities, and challenges: legal and intellectual property issues associated with stem cells (2021) (0)
Extended Shedding and Enhanced Fitness of the SARS-CoV-2 Variant of Concern B.1.1.7 in Human Organoid Systems (2021) (0)
Abstract 983: Wnt pathway activation involves inhibition of β-catenin ubiquitination within the endogenous Axin1 complex (2012) (0)
Oncogenic signalling is coupled to colorectal cancer cell differentiation state (2022) (0)
Cloning: history and current applications (2021) (0)
PS5 - 26. Modulation of GLP-1 secreting L-cells derived from intestinal stem cells (2011) (0)
194 Pancreatic ductal organoids as a new platform for drug discovery (2014) (0)
Abstract PR02: A mutational signature in human colorectal cancer induced by genotoxic pks+ E. coli (2020) (0)
Ablated intestinal stem cells recover predominantly by ASCL2-dependent dedifferentiation of their recent progeny (2020) (0)
Abstract SY12-04: Wnt, Lgr5 stem cells, and cancer (2010) (0)
Abstract LB-008: Patient derived organoids: Bringing the "patient in the lab" for pre-clinical and clinical development (2020) (0)
Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss (2023) (0)
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice (2018) (0)
What does the concept of the stem cell niche really mean today? (2012) (0)
Hematopoietic stem cells differentiate into restricted myeloid progenitors before cell division (2018) (0)
Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs (2023) (0)
T cell-specific regulation of the TCR/CD3-e gene (1989) (0)
Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits (2022) (0)
CAN-10-0315 Cancer esearch or and Stem Cell Biology lin D 2 – Cyclin-Dependent Kinase 4 / 6 Is Required for cient Proliferation and Tumorigenesis R wing Apc Loss (2010) (0)
P47.03 Understanding Lung Neuroendocrine Tumor Progression Combining Organoid Models and Multi-Omic Analyses (2021) (0)
Establishment and characterization of a new Pseudomonas aeruginosa infection model using 2D airway organoids and dual RNA sequencing (2023) (0)
Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors (2020) (0)
Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis (2023) (0)
Organoids in cancer research (2018) (0)
Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants (2023) (0)
MA02.03 The Evolution of Lung Neuroendocrine Tumors (2022) (0)
A love letter to the British people [1] (2016) (0)
The R-spondin protein family (2012) (0)
1 Lgr5 Stem Cells in Self-renewal and Cancer (2012) (0)
Polarizing intestinal epithelial cells electrically through Ror2 (2014) (0)
Druggable redox pathways against M. abscessus in cystic fibrosis patient-derived airway organoids (2022) (0)
Stem cells in veterinary medicine (2021) (0)
Crystal structure of R-spondin 1 (Fu1Fu2) - Native (2013) (0)
PS21 - 103. Multipotent pancreatic progenitor cells in 3D culture of human pancreatic ductal tissue: potential relevance for beta cell therapy in Type 1 diabetes (2012) (0)
DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints (2023) (0)
Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer (2022) (0)
Author response: KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition (2021) (0)
PS18 - 88. Expansion of human beta cell progenitors using a three-dimensional culture system (2011) (0)
Rectal Organoids Enable P ersonalized Treatment of Cystic Fibrosis Graphical (2019) (0)
Abstract LB-35: Living biobank of cancer organoids for drug development and screening (2014) (0)
Expression ofTacAntigen Component ofBovineInterleukin-2 Receptor inDifferent Leukocyte Populations Infected withTheileria parvaorTheileria annulata (1990) (0)
MP31-01 DEVELOPMENT OF NOVEL METASTATIC PROSTATE CANCER CELL LINES BY “ORGANOID” IN VITRO CULTURE TECHNOLOGY (2014) (0)
Proteomic Analysis of LGR 5 + ve Intestinal Adult Stem Cells and Their Immediate Undifferentiated (2013) (0)
Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation (2019) (0)
The next step in tissue culture (2010) (0)
Long term culture of genome-stable bipotent progenitor cells from adult human liver (2014) (0)
Abstract 989: Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages and can form chimeric mammary glands in vivo (2018) (0)
PolyG-DS: An ultrasensitive polyguanine tract–profiling method to detect clonal expansions and trace cell lineage (2021) (0)
Abstract CT075: Fasting-mimicking diet and hormone therapy modulates metabolic factors to promote breast cancer regression and reduce side effects (2020) (0)
Structure of ZNRF3-RSPO1 (2014) (0)
Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities. (2023) (0)
Abstract GMM-039: BUILDING AN ORGANOID-BASED MODEL FOR OVARIAN CANCER (2019) (0)
Chapter Aberrant Polycystin-1 Expression results in Modifi cation of AP-1 Activity , whereas Wnt Signaling remains unaffected 2 (2006) (0)
sample information of the human samples (2017) (0)
Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer. (2023) (0)
Organoids in immunological research (2019) (0)
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages (2020) (0)
Abstract 2794: A novel HNSCC organoid-on-a-chip platform for preclinical investigation and drug screening (2020) (0)
The T-Cell Receptor/T3 Complex on the Surface of Human and Murine T Lymphocytes (1988) (0)
PGE2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. (2023) (0)
Structure of ZNRF3 ectodomain (2014) (0)
Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer (2022) (0)
Cell fate specification and differentiation in the adult mammalian intestine (2020) (0)
Chromatin Remodeling in Patient-Derived Colorectal Cancer Models (2022) (0)
Bipotent Liver Progenitors Depend on Glycolysis and Mitochondrial Pyruvate Oxidation for Stem Cell Functions (2020) (0)
Establishment of a large-scale drug sensitivity screening platform on gastric cancer organoid cultures with potential to guide treatment (2018) (0)
Invasion into the bladder wall generates solitary subpopulations of uropathogenic Escherichia coli that are protected from killing by antibiotics and neutrophil swarms in an organoid model (2020) (0)
Abstract 59: Identifying tumor driving signaling pathways for companion diagnostics using computational pathway models. (2013) (0)
BRCA-deficient mouse mammary tumour organoids as a rapid tool to study anti-cancer drug resistance (2019) (0)
Lgr5-mediated restraint of β-catenin is essential for B-lymphopoiesis and leukemia-initiation (2020) (0)
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids (2023) (0)
Control of gene expression during lymphoid development: targeted gene disruption provides new clues (1997) (0)

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