Hans Westerhoff
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Dutch biologist
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Hans Westerhoffbiology Degrees
Biology
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Systems Biology
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#8
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Biotechnology
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Biochemistry
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Biology
Hans Westerhoff's Degrees
- PhD Biochemistry University of Amsterdam
Why Is Hans Westerhoff Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hans Victor Westerhoff is a Dutch biologist and biochemist who is professor of synthetic systems biology at the University of Amsterdam and AstraZeneca professor of systems biology at the University of Manchester. Currently he is a Chair of AstraZeneca and a director of the Manchester Centre for Integrative Systems Biology.
Hans Westerhoff's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations (2001) (1017)
- A community-driven global reconstruction of human metabolism (2013) (974)
- Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. (2000) (732)
- A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology (2008) (601)
- Quantification of the contribution of various steps to the control of mitochondrial respiration. (1982) (551)
- The evolution of molecular biology into systems biology (2004) (537)
- The nature of systems biology. (2007) (523)
- Thermodynamics and Control of Biological Free-Energy Transduction (1987) (472)
- Untangling the wires: A strategy to trace functional interactions in signaling and gene networks (2002) (413)
- Cancer: a Systems Biology disease. (2006) (377)
- Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway (2001) (357)
- The Glycolytic Flux in Escherichia coli Is Controlled by the Demand for ATP (2002) (339)
- Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. (1993) (306)
- Magainins and the disruption of membrane-linked free-energy transduction. (1989) (289)
- Introduction to systems biology. (2007) (271)
- The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels (2007) (249)
- The danger of metabolic pathways with turbo design. (1998) (246)
- Why cytoplasmic signalling proteins should be recruited to cell membranes. (2000) (237)
- Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes* (1997) (233)
- Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis. (2002) (220)
- Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure? (2000) (217)
- An alternative PII protein in the regulation of glutamine synthetase in Escherichia coli (1996) (210)
- Control of MAPK signalling: from complexity to what really matters (2005) (207)
- What Controls Glycolysis in Bloodstream Form Trypanosoma brucei?* (1999) (189)
- Metabolic control theory: its role in microbiology and biotechnology (1986) (189)
- Compartmentation protects trypanosomes from the dangerous design of glycolysis. (2000) (189)
- Expression of nitrite reductase in Nitrosomonas europaea involves NsrR, a novel nitrite‐sensitive transcription repressor (2004) (188)
- A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units. (1984) (187)
- Acetaldehyde mediates the synchronization of sustained glycolytic oscillations in populations of yeast cells. (1996) (185)
- Nitrogen Assimilation in Escherichia coli: Putting Molecular Data into a Systems Perspective (2013) (182)
- Systems Biology: Philosophical Foundations (2007) (182)
- Principles behind the multifarious control of signal transduction (2004) (177)
- Measuring enzyme activities under standardized in vivo‐like conditions for systems biology (2010) (174)
- Control analysis of metabolic systems (1985) (169)
- The Signal Transduction Function for Oxidative Phosphorylation Is at Least Second Order in ADP* (1996) (167)
- Quantification of information transfer via cellular signal transduction pathways (1997) (167)
- A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria. (2006) (163)
- Effects of sequestration on signal transduction cascades (2006) (162)
- GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition. (1998) (161)
- Control theory of regulatory cascades. (1991) (161)
- Emergence and Its Place in Nature: A Case Study of Biochemical Networks (2005) (153)
- Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes (2008) (151)
- Modern theories of metabolic control and their applications (1984) (148)
- How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control. (1984) (145)
- Intracellular Glucose Concentration in Derepressed Yeast Cells Consuming Glucose Is High Enough To Reduce the Glucose Transport Rate by 50% (1998) (144)
- Unraveling the complexity of flux regulation: A new method demonstrated for nutrient starvation in Saccharomyces cerevisiae (2006) (142)
- Functional synergism of the magainins PGLa and magainin-2 in Escherichia coli, tumor cells and liposomes. (1995) (140)
- Protein burden in Zymomonas mobilis: negative flux and growth control due to overproduction of glycolytic enzymes (1995) (139)
- Understanding Glucose Transport by the Bacterial Phosphoenolpyruvate:Glycose Phosphotransferase System on the Basis of Kinetic Measurements in Vitro * (2000) (136)
- Systems Biology: Definitions and Perspectives (2005) (132)
- Thermodynamic efficiency of microbial growth is low but optimal for maximal growth rate. (1983) (131)
- Modular response analysis of cellular regulatory networks. (2002) (131)
- How enzymes can capture and transmit free energy from an oscillating electric field. (1986) (129)
- How yeast cells synchronize their glycolytic oscillations: a perturbation analytic treatment. (2000) (128)
- Towards building the silicon cell: a modular approach. (2006) (128)
- Nitrite Reductase of Nitrosomonas europaea Is Not Essential for Production of Gaseous Nitrogen Oxides and Confers Tolerance to Nitrite (2002) (124)
- A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes (2013) (124)
- Structure and partitioning of bacterial DNA: determined by a balance of compaction and expansion forces? (1995) (122)
- Predictable Irreversible Switching Between Acute and Chronic Inflammation (2018) (121)
- Recurrent design patterns in the feedback regulation of the mammalian signalling network (2008) (121)
- Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations. (2000) (121)
- Thermodynamics of growth. Non-equilibrium thermodynamics of bacterial growth. The phenomenological and the mosaic approach. (1982) (118)
- Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization. (2004) (117)
- Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains. (2010) (116)
- FnrP and NNR of Paracoccus denitrificans are both members of the FNR family of transcriptional activators but have distinct roles in respiratory adaptation in response to oxygen limitation (1997) (116)
- Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production. (2011) (116)
- Mutational analysis of the nor gene cluster which encodes nitric-oxide reductase from Paracoccus denitrificans. (1996) (116)
- Implications of macromolecular crowding for signal transduction and metabolite channeling. (1998) (115)
- DNA supercoiling depends on the phosphorylation potential in Escherichia coli (1996) (113)
- Sustained oscillations in free‐energy state and hexose phosphates in yeast (1996) (111)
- Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. (2000) (111)
- DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase. (2002) (106)
- Integration of Mitochondrial Function (1988) (105)
- Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei. (1999) (105)
- Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. (1992) (100)
- Metabolic channelling and control of the flux (1993) (99)
- Can free energy be transduced from electric noise? (1987) (98)
- The use of lac-type promoters in control analysis. (1993) (98)
- Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics (2012) (98)
- Modular analysis of the control of complex metabolic pathways. (1993) (96)
- A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. (2000) (94)
- Nitrite and nitric oxide reduction in Paracoccus denitrificans is under the control of NNR, a regulatory protein that belongs to the FNR family of transcriptional activators (1995) (94)
- The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction (1997) (94)
- An in vivo control map for the eukaryotic mRNA translation machinery (2013) (92)
- Systems biology towards life in silico: mathematics of the control of living cells (2009) (92)
- Systems Biology: The elements and principles of Life (2009) (89)
- Control of glycolytic dynamics by hexose transport in Saccharomyces cerevisiae. (2001) (88)
- Quasi-linear relationship between Gibbs free energy of ATP hydrolysis and power output in human forearm muscle. (1995) (87)
- The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli (1993) (87)
- The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate. (1994) (85)
- Non-equilibrium thermodynamics of light absorption (1999) (85)
- Around the growth phase transition S. cerevisiae's make‐up favours sustained oscillations of intracellular metabolites (1993) (83)
- Super life – how and why ‘cell selection’ leads to the fastest‐growing eukaryote (2009) (83)
- Control and Regulation of Gene Expression (2008) (82)
- Control analysis for autonomously oscillating biochemical networks. (2002) (81)
- Mosaic protonic coupling hypothesis for free energy transduction (1984) (81)
- Nitrosomonas europaea Expresses a Nitric Oxide Reductase during Nitrification (2004) (80)
- Noise Management by Molecular Networks (2009) (80)
- Magainin 2 amide and analogues Antimicrobial activity, membrane depolarization and susceptibility to proteolysis (1989) (78)
- How to recognize monofunctional units in a metabolic system. (1996) (78)
- Electric potentiation, cooperativity, and synergism of magainin peptides in protein-free liposomes. (1993) (78)
- Signal transduction in bacteria: phospho-neural network(s) in Escherichia coli? (1995) (77)
- Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity (2016) (77)
- Nitric Oxide Is a Signal for NNR-Mediated Transcription Activation in Paracoccus denitrificans (1999) (77)
- Quantifying heterogeneity: flow cytometry of bacterial cultures (1991) (76)
- Bacteriorhodopsin in liposomes. II. Experimental evidence in support of a theoretical model. (1979) (76)
- Relationship between chemiosomotic flows and thermodynamic forces in oxidative phosphorylation. (1980) (75)
- A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect (2017) (73)
- Autoamplification of a Two-Component Regulatory System Results in “Learning” Behavior (2001) (73)
- Linear relation between rate and thermodynamic force in enzyme-catalyzed reactions (1980) (72)
- Building the cellular puzzle: control in multi-level reaction networks. (2001) (72)
- Metabolic control analysis indicates a change of strategy in the treatment of cancer. (2010) (72)
- Why in vivo may not equal in vitro – new effectors revealed by measurement of enzymatic activities under the same in vivo‐like assay conditions (2012) (71)
- Frequency–dependent incidence in models of sexually transmitted diseases: portrayal of pair–based transmission and effects of illness on contact behaviour (2004) (71)
- Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. (1997) (71)
- Hierarchical and metabolic regulation of glucose influx in starved Saccharomyces cerevisiae. (2005) (70)
- Channelling can decrease pool size. (1992) (70)
- Excess capacity of H(+)‐ATPase and inverse respiratory control in Escherichia coli. (1993) (70)
- Synchrony and mutual stimulation of yeast cells during fast glycolytic oscillations (1992) (69)
- Control analysis of glycolytic oscillations. (1996) (67)
- Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades (2002) (67)
- Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice (2008) (66)
- Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel. (1996) (65)
- Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria. (1989) (64)
- The Escherichia coli signal transducers PII (GlnB) and GlnK form heterotrimers in vivo: fine tuning the nitrogen signal cascade. (2000) (63)
- Integration of single-cell RNA-seq data into population models to characterize cancer metabolism (2019) (62)
- Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex (2010) (62)
- Yeast cells with a specific cellular make‐up and an environment that removes acetaldehyde are prone to sustained glycolytic oscillations (1994) (62)
- From isolation to integration, a systems biology approach for building the Silicon Cell. (2005) (61)
- Metabolic control analysis to identify optimal drug targets. (2007) (61)
- Absorption spectroscopy. (2011) (61)
- Geobacteraceae Community Composition Is Related to Hydrochemistry and Biodegradation in an Iron-Reducing Aquifer Polluted by a Neighboring Landfill (2005) (61)
- Macromolecular networks and intelligence in microorganisms (2014) (60)
- The multifarious short‐term regulation of ammonium assimilation of Escherichia coli: dissection using an in silico replica (2005) (59)
- Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics (2017) (59)
- How Molecular Competition Influences Fluxes in Gene Expression Networks (2011) (57)
- Temperature compensation through systems biology (2007) (56)
- The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. (1993) (56)
- Novel nirK Cluster Genes in Nitrosomonas europaea Are Required for NirK-Dependent Tolerance to Nitrite (2005) (56)
- Matrix method for determining steps most rate‐limiting to metabolic fluxes in biotechnological processes (1987) (56)
- An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade. (1995) (55)
- The methodologies of systems biology (2007) (55)
- A domino effect in drug action: from metabolic assault towards parasite differentiation (2011) (54)
- Regulation of expression of terminal oxidases in Paracoccus denitrificans. (2001) (54)
- The hypothesis of localized chemiosmosis is unsatisfactory. (1981) (54)
- Metabolic control analysis as a tool in the elucidation of the function of novel genes (1998) (54)
- Metabolic engineering in the post genomic era (2004) (53)
- The potential role of adenosine in the pathophysiology of the insulin resistance syndrome. (2001) (53)
- Recommendations for terminology and databases for biochemical thermodynamics. (2011) (52)
- On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator. (1987) (52)
- Synchronization of glycolytic oscillations in a yeast cell population. (2002) (52)
- Control Analysis of Periodic Phenomena in Biological Systems (1997) (52)
- The silicon cell, not dead but live! (2001) (51)
- Dynamic regulation of yeast glycolytic oscillations by mitochondrial functions. (1991) (51)
- Control analysis of the dependence of Escherichia coli physiology on the H(+)-ATPase. (1993) (50)
- Energetics of microbial growth: an analysis of the relationship between growth and its mechanistic basis by mosaic non-equilibrium thermodynamics (1982) (50)
- Putting intentions into cell biochemistry: an artificial intelligence perspective. (2002) (50)
- Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats. (2007) (50)
- Complex Stability and an Irrevertible Transition Reverted by Peptide and Fibroblasts in a Dynamic Model of Innate Immunity (2020) (50)
- Enzyme organization and the direction of metabolic flow: physicochemical considerations. (1992) (50)
- The regulatory strength: How to be precise about regulation and homeostasis (1993) (50)
- The macroworld versus the microworld of biochemical regulation and control. (1995) (49)
- Towards a rational approach to the optimization of flux in microbial biotransformations (1986) (49)
- The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells. (2000) (49)
- Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein (1999) (48)
- Glucose and the ATP paradox in yeast. (2000) (48)
- Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria. (1995) (46)
- Energy buffering of DNA structure fails when Escherichia coli runs out of substrate (1995) (46)
- A probabilistic approach to identify putative drug targets in biochemical networks (2011) (46)
- Systematic integration of experimental data and models in systems biology (2010) (45)
- Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes. (1998) (45)
- Bacteriorhodopsin in liposomes. I. A description using irreversible thermodynamics. (1979) (45)
- Modular kinetic analysis of the adenine nucleotide translocator-mediated effects of palmitoyl-CoA on the oxidative phosphorylation in isolated rat liver mitochondria. (2005) (45)
- Keeping a light-driven proton pump under control (1984) (45)
- BioComplexity: A pluralist research strategy is necessary for a mechanistic explanation of the "live" state (2002) (45)
- Branched-Chain α-Keto Acid Catabolism via the Gene Products of the bkd Operon in Enterococcus faecalis: a New, Secreted Metabolite Serving as a Temporary Redox Sink (2000) (44)
- Why the phosphotransferase system of Escherichia coli escapes diffusion limitation. (2003) (44)
- Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl‐CoA effects (2006) (44)
- How Geobacteraceae may dominate subsurface biodegradation: physiology of Geobacter metallireducens in slow-growth habitat-simulating retentostats. (2009) (43)
- Control of frequency and amplitudes is shared by all enzymes in three models for yeast glycolytic oscillations. (1996) (43)
- Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law. (2002) (43)
- On the Control of Gene Expression (1990) (43)
- Magainins affect respiratory control, membrane potential and motility of hamster spermatozoa (1991) (43)
- Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness. (2015) (43)
- Regulation of oxidative phosphorylation: The flexible respiratory network ofParacoccus denitrificans (1995) (42)
- The Extent to Which ATP Demand Controls the Glycolytic Flux Depends Strongly on the Organism and Conditions for Growth (2004) (42)
- AmtB‐mediated NH3 transport in prokaryotes must be active and as a consequence regulation of transport by GlnK is mandatory to limit futile cycling of NH 4 + / NH 3 (2011) (41)
- Analyses of dose-response curves to compare the antimicrobial activity of model cationic alpha-helical peptides highlights the necessity for a minimum of two activity parameters. (2006) (41)
- Dupuytren's: a systems biology disease (2011) (40)
- Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes (2015) (40)
- Systems biology tools for toxicology (2012) (39)
- Composite control of cell function: metabolic pathways behaving as single control units (1995) (39)
- Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering (2016) (39)
- What bio technologists knew all along...? (1996) (38)
- Design principles of nuclear receptor signaling: how complex networking improves signal transduction (2010) (38)
- Emergence of the silicon human and network targeting drugs. (2012) (38)
- Irreversible Thermodynamic Description of Energy Transduction in Biomembranes (1979) (38)
- Defining control coefficients in non-ideal metabolic pathways. (1995) (37)
- Regulation of the Activity of Lactate Dehydrogenases from Four Lactic Acid Bacteria* (2013) (37)
- Getting to the inside of cells using metabolic control analysis. (1994) (37)
- Yeast glycolytic oscillations that are not controlled by a single oscillophore: a new definition of oscillophore strength. (2005) (36)
- Biothermokinetics of the living cell (1996) (36)
- Targeting pathogen metabolism without collateral damage to the host (2017) (36)
- Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats. (2013) (36)
- SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation. (2009) (36)
- Extensive regulation compromises the extent to which DNA gyrase controls DNA supercoiling and growth rate of Escherichia coli. (1999) (35)
- Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells. (2007) (35)
- Mosaic nonequilibrium thermodynamics describes biological energy transduction. (1981) (35)
- The Probability to Initiate X Chromosome Inactivation Is Determined by the X to Autosomal Ratio and X Chromosome Specific Allelic Properties (2009) (35)
- Effects of Cadmium and Mercury on the Upper Part of Skeletal Muscle Glycolysis in Mice (2014) (34)
- ‘Channelled’ pathways can be more sensitive to specific regulatory signals (1993) (34)
- Linear nonequilibrium thermodynamics describes the dynamics of an autocatalytic system. (1991) (34)
- Control and Thermodynamics of Microbial Growth: Rational Tools for Bioengineering (1991) (34)
- Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy. (2013) (34)
- Ecological control analysis: being(s) in control of mass flux and metabolite concentrations in anaerobic degradation processes. (2007) (34)
- Rational cell culture optimization enhances experimental reproducibility in cancer cells (2017) (33)
- Regulation and control of compartmentalized glycolysis in bloodstream formTrypanosoma brucei (1995) (33)
- Synchronized Heat Flux Oscillations in Yeast Cell Populations* (1996) (33)
- Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes. (1994) (33)
- Control analysis of stationary forced oscillations. (1999) (32)
- Metabolic control in integrated biochemical systems. (2002) (32)
- Network-Based Selectivity of Antiparasitic Inhibitors (2004) (31)
- The NosX and NirX Proteins of Paracoccus denitrificans Are Functional Homologues: Their Role in Maturation of Nitrous Oxide Reductase (2000) (31)
- Time-dependent hierarchical regulation analysis: deciphering cellular adaptation. (2006) (30)
- Why does yeast ferment? A flux balance analysis study. (2010) (30)
- 'Slave' metabolites and enzymes. A rapid way of delineating metabolic control. (2000) (30)
- Signalling control strength. (2008) (30)
- Linear relations between proton current and pH gradient in bacteriorhodopsin liposomes. (1981) (30)
- Control, responses and modularity of cellular regulatory networks: a control analysis perspective. (2008) (30)
- Control of glycolytic flux in Zymomonas mobilis by glucose 6‐phosphate dehydrogenase activity (1996) (29)
- Determining and understanding the control of flux. An illustration in submitochondrial particles of how to validate schemes of metabolic control. (1999) (29)
- Demonstration of coupling between the protonmotive force across bacteriorhodopsin and the flow through its photochemical cycle (1978) (29)
- Control of DNA structure and gene expression. (1990) (29)
- The reduction state of the Q-pool regulates the electron flux through the branched respiratory network of Paracoccus denitrificans. (2001) (29)
- The silicon trypanosome (2010) (29)
- BDI-modelling of complex intracellular dynamics. (2008) (29)
- Control by enzymes, coenzymes and conserved moieties (1994) (29)
- Dynamical and hierarchical coupling (1990) (29)
- Time‐dependent regulation analysis dissects shifts between metabolic and gene‐expression regulation during nitrogen starvation in baker’s yeast (2009) (29)
- Ample Arsenite Bio-Oxidation Activity in Bangladesh Drinking Water Wells: A Bonanza for Bioremediation? (2019) (28)
- Health technology assessment in the era of personalized health care (2011) (28)
- Control of mitochondrial respiration. (1983) (28)
- Cooperative P‐glycoprotein mediated daunorubicin transport into DNA‐loaded plasma membrane vesicles (1994) (28)
- HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium. (2011) (28)
- STRENDA DB: enabling the validation and sharing of enzyme kinetics data (2018) (28)
- ROS networks: designs, aging, Parkinson’s disease and precision therapies (2020) (28)
- Metabolic control and compartmentation in single living cells (1983) (27)
- Control theory of one enzyme. (1994) (27)
- Selectivity in overlapping MAP kinase cascades. (2002) (27)
- On the expected relationship between Gibbs energy of ATP hydrolysis and muscle performance. (1995) (27)
- Mechanisms for the interaction between nonstationary electric fields and biological systems II. Nonlinear dielectric theory and free-energy transduction (1988) (27)
- (Im)Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis (2013) (27)
- Monte-Carlo Modeling of the Central Carbon Metabolism of Lactococcus lactis: Insights into Metabolic Regulation (2014) (27)
- Retraction Notice to: Population-Level Transcription Cycles Derive from Stochastic Timing of Single-Cell Transcription (2010) (27)
- Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus (2013) (27)
- Mechanisms for the interaction between nonstationary electric fields and biological systems I. Linear dielectric theory and its limitations (1988) (26)
- A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells (2012) (26)
- Towards philosophical foundations of Systems Biology: introduction (2007) (26)
- Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated. (1996) (26)
- Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism (2015) (26)
- Training of yeast cell dynamics (2005) (26)
- Metabolic control by pump slippage and proton leakage in 'delocalized' and more localized chemiosmotic energy-coupling schemes. (1983) (26)
- THe proton-per-electron stoicheiometry of 'site 1' of oxidative phosphorylation at high protonmotive force is close to 1.5. (1982) (25)
- Iron Cycling Potentials of Arsenic Contaminated Groundwater in Bangladesh as Revealed by Enrichment Cultivation (2016) (25)
- Cytochromes c550,c552, and c1 in the Electron Transport Network of Paracoccus denitrificans: Redundant or Subtly Different in Function? (2001) (25)
- Control theory of metabolic channelling (1994) (24)
- Coupling of vectorial proton flow to a biochemical reaction by local electric interactions. (1988) (24)
- Systems Biology: Did we know it all along? (2005) (24)
- A plasma membrane 'vacuum cleaner' for daunorubicin in non-P-glycoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells. A study using fluorescence resonance energy transfer. (1993) (24)
- Kinetic Modeling of Energy Metabolism and Superoxide Generation in Hepatocyte Mitochondria (2001) (24)
- Simplicity in complexity: the photosynthetic reaction center performs as a simple 0.2 V battery (2002) (24)
- Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations (2009) (24)
- Optimization of stress response through the nuclear receptor-mediated cortisol signalling network (2013) (24)
- RETRACTED: Population-Level Transcription Cycles Derive from Stochastic Timing of Single-Cell Transcription (2009) (23)
- Control analysis of metabolic systems involving quasi-equilibrium reactions. (1998) (23)
- Stochastic free energy transduction. (1985) (23)
- DNA supercoiling by DNA gyrase (2008) (23)
- The thermodynamic basis for the partial control of oxidative phosphorylation by the adenine-nucleotide translocator (1983) (23)
- Experimental determination of control by the H+-ATPase inEscherichia coli (1995) (23)
- INTERACTION OF NITROGEN FIXATION AND PHOSPHORUS LIMITATION IN APHANIZOMENON FLOS‐AQUAE (CYANOPHYCEAE) 1 (1997) (22)
- Macromolecular Intelligence in Microorganisms (2000) (22)
- Redox interactions in cytochrome c oxidase: from the "neoclassical" toward "modern" models. (1992) (22)
- Sigmoidal relation between mitochondrial respiration and log ([ATP]/[ADP])out under conditions of extramitochondrial ATP utilization. Implications for the control and thermodynamics of oxidative phosphorylation. (1988) (22)
- Changes in the cellular energy state affect the activity of the bacterial phosphotransferase system. (1996) (22)
- Cellular information transfer regarded from a stoichiometry and control analysis perspective. (2000) (21)
- [Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria]. (2001) (21)
- Subtlety in control--metabolic pathway engineering. (1995) (21)
- Yes. Kinetics alone are impracticable (1982) (20)
- Mixed and diverse metabolic and gene-expression regulation of the glycolytic and fermentative pathways in response to a HXK2 deletion in Saccharomyces cerevisiae. (2008) (20)
- CONTROL THEORY OF GROUP TRANSFER PATHWAYS (1995) (20)
- Loss of Fermentative Capacity in Baker's Yeast can Partly be Explained by Reduced Glucose Uptake Capacity (2004) (20)
- A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. (2012) (20)
- Molecular control analysis: control within proteins and molecular processes. (1996) (20)
- Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies. (2013) (20)
- Thermodynamics of complexity. The live cell (1998) (19)
- HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium. (2011) (19)
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- Control of DNA supercoiling in the procaryotic cell. (1996) (0)
- Tumor Progression and Catastrophe Theory (1993) (0)
- Control of Bacterial Growth by Membrane Processes (1989) (0)
- Microbes-Assisted Arsenate Reduction Activity in Bangladesh Drinking Water Wells as Revealed by Enrichment Cultivation (2022) (0)
- Additional file 3: of Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity (2016) (0)
- Clusters of reaction rates and concentrations in protein networks such as the phosphotransferase system (2014) (0)
- Control of DNA supercoiling in the procaryotic cell. (1996) (0)
- Systems Biology - Is Europe taking up the Grand Challenge? (2007) (0)
- Differential control analysis: quantitative understanding of the adaptive responses of intracellular networks and its use in antiparasitic drug design (2001) (0)
- Systems Biology has reached adulthood ..... in some places. (2011) (0)
- Erratum : DNA supercoiling by gyrase is linked to nucleoid compaction (Molecular Biology Reports (2002) 29(79-82) (2003) (0)
- Abstract 4336: Design of a chamber for studying glucose metabolism by anoxic cancer cells (2014) (0)
- Letters to the Editor. (1998) (0)
- ISBE report on global standards, methods and training procedures. (2015) (0)
- ISBE portfolio of showcases illustrating the impact of modelling. (2014) (0)
- Modular control analysis: are membranes or cytosol more important for growth fo the industrial yeast Kluyweromyces marxianus? (2000) (0)
- Regulation and control seen through the eyes of a physicist (1996) (0)
- Systems Biology in ELIXIR: modelling in the spotlight (2022) (0)
- Is acetate the synchronizing agent for yeast cells during sustained glycolytic oscillations (1993) (0)
- A backbone to systems biology and multifactorial disease: systems biology of mineralization, bone formation and osteoporosis (2006) (0)
- Intermediate report on the definition of criteria and preliminary map of ISBE centres (2015) (0)
- Metabolic engineering in the post genomic era: what it should become. (2004) (0)
- How to organise and run an ISBE modelling service (2015) (0)
- Final report with all connections for the implementation phase defined (2015) (0)
- NET works after all? Engineering robustness through diversity (2018) (0)
- UvA-DARE ( Digital Academic Repository ) Neutral metalloaminopeptidases APN and MetAP 2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs (2018) (0)
- Systems Biology in Europe ...... a fermenting paradox. (2005) (0)
- Control analysis of modular metabolic networks. (1994) (0)
- Report of an EU projects workshop on systems biology held in Brussels, Belgium on 8 December 2004. (2005) (0)
- Multiplicity of Control (1993) (0)
- ROS homeostasis in a dynamic model: How to save PD neuron? (2014) (0)
- Control of Dynamics and Steady State: Applications to Multidrug Resistance (1996) (0)
- A rapid way of delineating metabolic control (2000) (0)
- GLNK, A SIGNAL PROTEIN FROM E. COLI (1999) (0)
- Cancer chemotherapy in terms of metabolic control analysis (1998) (0)
- ROS systems biology: In silico reconstruction of the emergence of cellular ROS-managing system (2013) (0)
- Experimental Determination of Control by the H § in Escherichia coli (0)
- Extended abstract: BDI-Modelling of Intracellular Dynamics (2002) (0)
- Adenine nucleotide translocator - A candidate for mediating long chain acyl-CoA effects in type 2 diabetes (2007) (0)
- Metabolic Control Analysis as a Method to Assess Mitochondrial Dysfunction (1993) (0)
- Recommendations for performing measurements of apparent equilibrium constants of enzyme-catalyzed reactions and for reporting the results of these measurements (2023) (0)
- Molecular analysis of the vaginal microbiome: an alternative for the diagnosis of bacterial vaginosis? (2015) (0)
- An in vivo assay for metabolic regulation? Control by a metabolic variable. (2000) (0)
- Metabolic control by the redox-state of the Q-pool in the respiratory network of Paracoccus denitrificans. (1998) (0)
- Metabolic control analysis reveals that glucose transport incompletely controls the glycolytic flux in Trypanosoma brucei (1998) (0)
- ISBE - draft proposal on connections (2014) (0)
- THE MEMBRANES INVOLVED IN PROTON-MEDIA TED FREE-ENERGY TRANSDUCTION: THERMODYNAMIC IMPLICATIONS OF THElR (2020) (0)
- ISBE - resource assessment for a European modelling service: Report detailing all the findings and activities on Task 2 (2015) (0)
- Transcriptome and proteome analysis of Saccharomyces cerevisiae metabolic response to glucose and ethanol as carbon sources (2004) (0)
- Henrik Kacser (1918–1995): metabolism of control (1995) (0)
- Internal glucose concentration is a major determinant of the rate of glucose influx in Saccharomyces cerevisiae (1997) (0)
- Design principles of nuclear receptor signalling: How complex networking improves signal transduction (2011) (0)
- Report on the proposed organisation, governance and legal structure of ISBE (2015) (0)
- Book Review:Regulation and Control Mechanisms in Biological Systems. Vishnampet S. Vaidhyanathan (1995) (0)
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