Harald von Boehmer

Harald von Boehmer's AcademicInfluence.com Rankings

Harald von Boehmer

Biology

#1488

World Rank

#2483

Historical Rank

Immunology

#81

World Rank

#87

Historical Rank

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Biology

Why Is Harald von Boehmer Influential?

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According to Wikipedia, Harald von Boehmer was a German-Swiss immunologist best known for his work on T cells. Career The youngest of Hasso von Boehmer's three children, von Boehmer obtained an M.D. from the Ludwig Maximilian University of Munich and a Ph.D. from Melbourne University, Australia . He was a member of the Basel Institute for Immunology in Switzerland , director of Unité INSERM 373 at the René Descartes University in Paris, France and is Professor of Pathology at Harvard Medical School and the Faculty of Arts and Sciences of Harvard University, Cambridge and Chief of the Laboratory for Lymphocyte Biology at the Dana Farber Cancer Institute in Boston. He was an adjunct professor at the University of Florida.

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Harald von Boehmer's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein (2002) (2351)
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes (1988) (1796)
Inducing and expanding regulatory T cell populations by foreign antigen (2005) (1380)
Origin of regulatory T cells with known specificity for antigen (2002) (980)
Mechanisms of suppression by suppressor T cells (2005) (877)
In Vivo Instruction of Suppressor Commitment in Naive T Cells (2004) (822)
DNA methylation controls Foxp3 gene expression (2008) (757)
Foxp3 occupancy and regulation of key target genes during T-cell stimulation (2007) (753)
Peripheral selection of the T cell repertoire. (1991) (726)
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo (2005) (715)
Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells (1988) (657)
Positive selection of antigen-specific T cells in thymus by restricting MHC molecules (1988) (655)
MHC class I expression in mice lacking the proteasome subunit LMP-7. (1994) (555)
Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor (1994) (516)
Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells (1995) (496)
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro (2003) (486)
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. (2006) (486)
Development and selection of T cells: facts and puzzles. (1995) (481)
Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules (1997) (474)
Developmental biology of T cells in T cell-receptor transgenic mice. (1990) (468)
Transfer of specificity by murine α and β T-cell receptor genes (1986) (462)
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia (2006) (451)
Analysis and expression of a cloned pre-T cell receptor gene. (1994) (445)
Frontline: Neuropilin‐1: a surface marker of regulatory T cells (2004) (442)
Positive selection of lymphocytes (1994) (410)
Structure and function of the pre-T cell receptor. (1997) (404)
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. (2005) (401)
Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice (1991) (398)
The thymus selects the useful, neglects the useless and destroys the harmful. (1989) (387)
In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes (1988) (372)
A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein (1993) (364)
Requirement for cyclin D3 in lymphocyte development and T cell leukemias. (2003) (362)
Exclusion and inclusion of α and β T cell receptor alleles (1992) (353)
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice. (1978) (346)
Self-nonself discrimination by T cells. (1990) (317)
Fine specificity of a continuously growing killer cell clone specific for H‐Y antigen (1979) (306)
Mechanisms of suppression by suppressor T cells (2005) (298)
Checkpoints in lymphocyte development and autoimmune disease (2010) (298)
Expression of T-cell antigen receptor genes during fetal development in the thymus (1985) (297)
Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. (2007) (293)
The requirement for cyclin D function in tumor maintenance. (2012) (292)
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes (1981) (291)
CD 69 expression during selection and maturation of CD4+8+ thymocytes (1993) (282)
A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. (1996) (278)
Early αβ T cell development in the thymus of normal and genetically altered mice (1997) (259)
Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules (1989) (253)
Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells (1991) (253)
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity (2009) (242)
Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. (2005) (241)
Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo (1998) (240)
Genomic definition of multiple ex vivo regulatory T cell subphenotypes (2010) (239)
Ontogeny of the T-cell antigen receptor within the thymus (1985) (233)
Developmental biology of T cells in T cell-receptor transgenic mice. (1990) (231)
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage (1991) (228)
Pleiotropic changes controlled by the pre-T-cell receptor. (1999) (227)
Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential (2003) (226)
The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens (1989) (223)
Thymic selection revisited: how essential is it? (2003) (222)
The transcriptional landscape of αβ T cell differentiation (2013) (214)
The developmental biology of T lymphocytes. (1988) (213)
Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation (2006) (210)
Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen (1993) (200)
Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis (2002) (199)
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer (2012) (198)
Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT (2001) (197)
Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development (2001) (196)
Positive selection of lymphocytes. (1994) (194)
The separation of different cell classes from lymphoid organs. IX. A simple and rapid method for removal of damaged cells from lymphoid cell suspensions. (1973) (185)
The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells (1996) (179)
A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. (2006) (176)
On the cellular basis of immunological T cell memory. (1995) (175)
Conditions That Induce Tolerance in Mature CD4+ T Cells (1997) (171)
Transfection of the CD8 gene enhances T-cell recognition (1987) (167)
Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. (1995) (166)
Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut. (1992) (164)
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines (2009) (161)
Crucial role of the pre-T-cell receptor α gene in development of αβ but not γ§ T cells (1995) (160)
Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus. (1997) (160)
Different initiation of pre-TCR and γδTCR signalling (2000) (158)
Transcription of T cell receptor beta‐chain genes is controlled by a downstream regulatory element. (1988) (157)
Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. (1994) (152)
Development of the CD4 and CD8 lineage of T cells: instruction versus selection. (1991) (151)
PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors (2010) (150)
Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells (1984) (148)
An unusual lineage of alpha/beta T cells that contains autoreactive cells (1991) (147)
Allelic inclusion of T cell receptor alpha genes poses an autoimmune hazard due to low-level expression of autospecific receptors. (1998) (147)
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes (2004) (144)
T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes (1988) (144)
Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras (1975) (143)
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. (1988) (142)
Anergy and suppression regulate CD4+ T cell responses to a self peptide (2000) (142)
Association of immunity and tolerance to host H-2 determinants in irradiated F1 hybrid mice reconstituted with bone marrow cells from one parental strain (1975) (141)
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut (2012) (141)
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival (2005) (141)
Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice (1992) (140)
Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. (2007) (138)
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope (2011) (138)
Thymic selection: a matter of life and death (1992) (137)
Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias (2002) (132)
The life span of naive alpha/beta T cells in secondary lymphoid organs (1993) (130)
Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. (2006) (130)
Role of Different T Cell Receptors in the Development of Pre–T Cells (1997) (128)
Transfer of specificity by murine alpha and beta T-cell receptor genes. (1986) (126)
In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. (1988) (126)
Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen (1979) (124)
Cyclin C is a haploinsufficient tumour suppressor (2014) (124)
Successful Interference with Cellular Immune Responses to Immunogenic Proteins Encoded by Recombinant Viral Vectors (2001) (124)
Crucial function of the pre‐T‐cell receptor (TCR) in TCRP selection, TCRβ allelic exclusion and αβ versus γδ lineage commitment (1998) (122)
Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide–MHC class II chimera (2002) (121)
The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer. (2006) (120)
Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. (1991) (120)
T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. (1992) (118)
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras (1975) (118)
On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. (2005) (117)
Antigen-Specific FoxP 3-Transduced T-Cells Can Control Established Type 1 Diabetes (2005) (116)
Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL (2011) (116)
c-Myc mediates pre-TCR-induced proliferation but not developmental progression. (2006) (114)
The selection of the α,β heterodimeric T-cell receptor for antigen. (1986) (114)
Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells. (1984) (113)
Intra‐ and extra‐thymic expression of the pre‐T cell receptor α gene (1995) (112)
The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia (2013) (111)
A role for a pre-T-cell receptor in T-cell development. (1993) (111)
Fingerprints of anergic T cells (2001) (110)
Stabilization of β-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia (2002) (110)
Dissociation of two signals required for activation of resting B cells. (1982) (108)
Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα (1997) (107)
Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer (2006) (106)
On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment (1998) (106)
CD4+8− help prevents rapid deletion of CD8+ cells after a transient response to antigen (1993) (106)
Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate (2006) (106)
The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit (1995) (105)
Characterization of T Cell Differentiation in the Murine Gut (2002) (105)
T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis (2008) (105)
On the brink of becoming a T cell. (2002) (104)
Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells (1986) (104)
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1 (2008) (101)
Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2 (1985) (100)
The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development (1999) (100)
Expression of M locus differences by B cells but not T cells (1974) (98)
Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase (2003) (96)
Early Deletion and Late Positive Selection of T-Cells Expressing a Male-Specific Receptor in T-Cell Receptor Transgenic Mice (1990) (95)
Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression (2008) (94)
H‐2 Restricted Cytolytic and Noncytolytic T Cell Clones: Isolation, Specificity and Functional Analysis (1981) (94)
Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. (2005) (93)
Identification of a T lineage-committed progenitor in adult blood. (2007) (93)
Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes. (1975) (93)
Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene (2002) (92)
Cell division in the compartment of naive and memory T lymphocytes (1996) (91)
Developmental Biology of T Lymphocytes (1988) (90)
Helper function of T cells depleted of alloantigen-reactive lymphocytes by filtration through irradiated F1 hybrid recipients. I. Failure to collaborate with allogeneic B cells in a secondary response to sheep erythrocytes measured in vivo (1976) (89)
Enhancement of antigen-specific Treg vaccination in vivo (2010) (87)
Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development. (2004) (84)
Kruppel-like Factor KLF10 Targets Transforming Growth Factor-β1 to Regulate CD4+CD25− T Cells and T Regulatory Cells* (2009) (84)
RAG1, RAG2 and pre‐T cell receptor α chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation (1996) (83)
Unique features of the pre-T-cell receptor α-chain: not just a surrogate (2005) (81)
Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. (2008) (81)
Pre‐TCR‐triggered ERK signalling‐dependent downregulation of E2A activity in Notch3‐induced T‐cell lymphoma (2003) (79)
Separation of T and B Lymphocytes and Their Role in the Mixed Lymphocyte Reaction (1974) (79)
Peripherally Induced Treg: Mode, Stability, and Role in Specific Tolerance (2008) (78)
Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development. (2004) (78)
Lymphocyte lineage commitment: Instruction versus selection (1993) (78)
Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells (2010) (77)
Shaping the T cell repertoire. (2006) (77)
Five types of lymphocytes (lg− θ−, lg− θ+ weak, lg− θ+strong, lg+ θ− and lg+ θ+) characterized by double immunofluorescence and electrophoretic mobility Organ distribution in normal and nude mice (1975) (77)
Regulatory function of in vivo anergized CD4+ T cells (2001) (77)
Oral tolerance: is it all retinoic acid? (2007) (75)
Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes (2003) (74)
Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells (1976) (74)
Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes (1992) (73)
αβ versus γδ fate choice: counting the T‐cell lineages at the branch point (2010) (73)
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. (2006) (72)
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. (2010) (71)
β-Selection-induced proliferation is required for αβ T cell differentiation. (2012) (70)
Constitutive Endocytosis and Degradation of the Pre-T Cell Receptor (2002) (70)
A critical role for the cytoplasmic tail of pTα in T lymphocyte development (2002) (69)
Requirements for growth of immature thymocytes from fetal and adult mice in vitro (1986) (68)
Negative selection of the T‐cell repertoire: where and when does it occur? (2006) (65)
Lyt-2- T cell-independent functions of Lyt-2+ cells stimulated with antigen or concanavalin A. (1984) (62)
On the various manifestations of spontaneous autoimmune diabetes in rodent models (1994) (62)
Dynamics of suppressor T cells: in vivo veritas. (2003) (62)
H‐2 gene complementation in cytotoxic T cell responses of female against male cells (1977) (62)
Early alpha beta T cell development in the thymus of normal and genetically altered mice. (1997) (62)
Exclusion and inclusion of alpha and beta T cell receptor alleles. (1992) (61)
Different initiation of pre-TCR and gammadeltaTCR signalling. (2000) (60)
Changes in function of antigen‐specific lymphocytes correlating with progression towards diabetes in a transgenic model (1998) (59)
Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development (2004) (59)
Early expression of a T-cell receptor beta-chain transgene suppresses rearrangement of the V gamma 4 gene segment. (1988) (59)
Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands (2006) (58)
T cell receptor β chain dimers on immature thymocytes from normal mice (1993) (57)
Visualizing the course of antigen‐specific CD8 and CD4 T cell responses to a growing tumor (2003) (57)
Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells (1990) (56)
Allelic Exclusion of the T Cell Receptor β Locus Requires the Sh2 Domain–Containing Leukocyte Protein (Slp)-76 Adaptor Protein (1999) (55)
T Cell Function in Bone Marrow Chimeras; Absence of Host‐Reactive T Cells and Cooperation of Helper T Cells across Allogeneic Barriers (1976) (55)
Cytotoxic T cell responses to haptenated cells III. Isolation and specificity analysis of continuously growing clones (1980) (54)
BCL-2 and BCL-XL Restrict Lineage Choice during Hematopoietic Differentiation* (2003) (54)
Multiple extrathymic precursors contribute to T-cell development with different kinetics. (2010) (53)
Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping (2008) (53)
Thymic selection: a matter of life and death. (1992) (52)
Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection. (1992) (52)
Syngeneic mixed lymphocyte reaction between thymocytes and peripheral lymphoid cells in mice: strain specificity and nature of the target cell. (1973) (52)
Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. (1995) (50)
Structural Basis for the Transition from Initiation to Elongation Transcription in T 7 RNA Polymerase (50)
Absolute requirement for the pre‐T cell receptor α chain during NK1.1+ TCRα β cell development (1999) (50)
Allelic Exclusion in pTα-deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-β Chains, but Less Efficient Inhibition of Endogeneous Vβ→ (D)Jβ Rearrangements in the Presence of a Functional TCR-β Transgene (1997) (49)
De novo production of antigen-specific suppressor cells in vivo (2006) (48)
Pancreatic NOD beta cells express MHC class II protein and the frequency of I-Ag7 mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes (2003) (47)
PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function (2012) (47)
Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. (2002) (46)
The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. (1996) (45)
The Expression of CD4 and CD8 Accessory Molecules on Mature T Cells is not Random but Correlates with the Specificity of the αβ Receptor for Antigen (1989) (44)
Oral tolerance: is it all retinoic acid? (2007) (43)
Cytotoxic T cell responses to haptenated cells I. Primary, secondary and long‐term cultures (1979) (42)
An Unusual Lineage of oL / / 3 T Cells that Contains Autoreactive Cells (2003) (42)
CD4/CD8 lineage commitment: back to instruction? (1996) (41)
Negative and positive selection of immature thymocytes: timing and the role of the ligand for alpha beta T cell receptor. (1990) (41)
NATURE OF THE STIMULATING CELL IN THE SYNGENEIC AND THE ALLOGENEIC MIXED LYMPHOCYTE REACTION IN MICE (1972) (40)
Autoimmune insulitis and diabetes in the absence of antigen‐specific contact between T cells and β‐islet cells (1999) (39)
A human CD4 transgene rescues CD4−CD8+ cells in β2‐microglobulin‐deficient mice (1994) (39)
The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens. (1989) (39)
Regulation of T cell production in T cell receptor transgenic mice (1993) (39)
A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. (2002) (38)
Antigen-initiated B lymphocyte differentiation. V. Electrophoretic separation of different subpopulations of AFC progenitors for unprimed IgM and memory IgG responses to the NIP determinant. (1975) (38)
The role of the thymus in maturational development of phytohemagglutinin and pokeweed mitogen responsiveness. (1973) (38)
Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells. (1998) (37)
The T‐Cell Receptor for Antigen in T‐Cell Development and Repertoire Selection (1988) (37)
Selection of the T cell repertoire during ontogeny: Limiting dilution analysis (1982) (36)
Positive and negative selection of the αβ T-cell repertoire in vivo (1991) (36)
Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex (1999) (35)
Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity. (2006) (34)
Monitoring gene expression of TNFR family members by β‐cells during development of autoimmune diabetes (2000) (34)
On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment. (1998) (34)
Nature of T cell‐macrophage interaction in helper cell induction in vitro I. Evidence for genetic restriction of T cell‐macrophage interactions prior to T cell priming (1978) (34)
CD4/CD8 lineage commitment: back to instruction? (1996) (32)
The Biological Activity of Natural and Mutant Ptα Alleles (2001) (32)
Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha. (1997) (31)
TCR and Notch synergize in αβ versus γδ lineage choice (2007) (31)
Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain. (1996) (31)
Small CD4+8+TCRlow thymocytes contain precursors of mature T cells (1994) (29)
gammadeltaTCR ligands and lineage commitment. (2010) (29)
Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint. (2010) (29)
Notch Signaling in T-Cell Development and T-ALL (2011) (28)
Subpopulations of T‐Lymphocytes (1975) (28)
Immunoglobulin turnover in B lymphocyte subpopulations (1975) (28)
Progress in Immunology (1989) (27)
Thymus and autoimmunity (2003) (27)
Cytotoxic T cells recognize male antigen and H-2 as distinct entities (1978) (27)
Characterization of cloned murine cytolytic T cell lines. (1980) (27)
How the immune system learns about self. (1991) (26)
T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes. (1988) (26)
Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes (2013) (25)
Positive Selection of Immature αβ T Cells (1993) (25)
Positive and Negative Selection of T Cells (1992) (25)
The Eδ enhancer controls the generation of CD4−CD8− αβTCR-expressing T cells that can give rise to different lineages of αβ T cells (2006) (25)
Uveal non-Hodgkin's lymphoma with epibulbar extension simulating choroidal effusion syndrome. (1999) (25)
T-helper function of parent leads to F1 chimeras. Presence of a separate T-cell subgroup able to stimulate allogeneic B cells but not syngeneic B cells (1979) (25)
Class II essential for CD4 survival (2001) (24)
Molecular, cellular, and functional properties of bone marrow T lymphocyte progenitor clones [published erratum appears in J Exp Med 1988 Jun 1;167(6):2023] (1987) (24)
Intra- and extra-thymic expression of the pre-T cell receptor alpha gene. (1995) (24)
Genomic structure of the human pre‐T cell receptor α chain and expression of two mRNA isoforms (1998) (23)
Lymphotoxins: from cytotoxicity to lymphoid organogenesis. (1997) (22)
Extrathymic generation of regulatory T cells--chances and challenges for prevention of autoimmune disease. (2011) (22)
TCR and Notch synergize in alphabeta versus gammadelta lineage choice. (2007) (22)
Immunohistology of T cell differentiation in the thymus of H‐Y‐specific T cell receptor α/β transgenic mice (1990) (22)
Subpopulations of B lymphocytes: physical separation of functionally distinct stages of B-cell differentiation. (1976) (21)
Antigen-specific induction of regulatory T cells in vivo and in vitro. (2011) (21)
Haptenation of Viable Biological Carriers (1979) (20)
False-positive EMIT indication of opiates and methadone in a doxylamine intoxication. (1983) (20)
What turns on Foxp3? (2008) (20)
Characterization of immunoglobulin-bearing and other small lymphocytes in mouse bone marrow by sedimentation and electrophoresis. (1975) (19)
The role of T-cell receptor α and β genes in MHC-restricted antigen recognition. (1986) (19)
T-cell lineage fate: Instructed by receptor signals? (2000) (19)
Coming to Grips with Notch (2001) (19)
TCR alpha-chain repertoire in pTalpha-deficient mice is diverse and developmentally regulated: implications for pre-TCR functions and TCRA gene rearrangement. (1999) (18)
Cytotoxic T cell responses to haptenated cells II. On the role of H‐2 genes (1979) (18)
Surface immunoglobulins of peripheral thymus-derived lymphocytes. (1974) (18)
Frontline: Neuropilin‐1: a surface marker of regulatory T cells (Vol. 34(3) 2004, pp 623–630, DOI 10.1002/eji.200324799) (2004) (17)
GAD, a Single Autoantigen for Diabetes (1999) (17)
The impact of pre-T-cell receptor signals on gene expression in developing T cells. (1999) (17)
The TCR-HA, INS-HA transgenic model of autoimmune diabetes: limitations and expectations. (2004) (17)
Surface expression and functional competence of CD3-independent TCR zeta-chains in immature thymocytes. (1999) (17)
The TAL 1 complex targets the FBXW 7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia (2013) (17)
Selective stimulation by B lymphocytes in the syngeneic mixed lymphocyte reaction (1974) (17)
Gene transfer and genetic modification of embryonic stem cells by Cre‐ and Cre‐PR‐expressing MESV‐based retroviral vectors (2004) (16)
Mechanisms of self-nonself discrimination and possible clinical relevance. (2009) (16)
p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. (2007) (16)
A new 12-kilodalton dimer associated with pre-TCR complex and clonotype-independent CD3 complex on immature thymocytes. (1997) (16)
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice ( generation of diversity / chimera / T-cell receptor ) (16)
Control of T-Cell Development by the Pre-T and αβ T-Cell Receptor (1995) (16)
Regulatory T cells (2006) (15)
Techniques for separation and selection of antigen specific lymphocytes. (1978) (15)
Tolerance by exhaustion (1993) (15)
Central tolerance: Clonal deletion or clonal arrest? (1994) (15)
Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development. (1999) (14)
The role of the left end of the H‐2b haplotype in the male‐specific cytotoxic T cell response (1979) (14)
Fc‐rosetting and nonrosetting T cells are killer cells (1976) (14)
A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice. (1994) (13)
Extra-thymically induced regulatory T cells: do they have potential in disease prevention? (2011) (13)
The Thymus in Immunity and in Malignancy (2014) (13)
T-cell development: Is Notch a key player in lineage decisions? (1997) (13)
Oncogenesis of TALL and nonmalignant consequences of overexpressing intracellular NOTCH 1 (2008) (12)
Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene (2004) (12)
T cell development and selection in the thymus. (1992) (12)
Methods for the establishment of continuously growing cytolytic T cell clones. (1982) (12)
Unique features of the pre-T-cell receptor α-chain: not just a surrogate (2005) (12)
Type 1 diabetes: focus on prevention (2004) (12)
Lymphotoxins: From cytotoxicity to lymphoid organogenesis (1997) (11)
T-cell development: What does Notch do for T cells? (1999) (10)
Coming to Grips with Notch (2001) (10)
Peptide-Based Instruction of Suppressor Commitment in Naïve T Cells and Dynamics of Immunosuppression in vivo (2005) (10)
Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. (1998) (10)
Central tolerance: essential for preventing autoimmune disease? (2009) (10)
Aspects of lymphocyte developmental biology. (1997) (9)
Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens (2009) (9)
T cell development and selection in the thymus. (1992) (9)
Peptide-based instruction of suppressor commitment in naïve T cells and dynamics of immunosuppression in vivo. (2005) (9)
Lymphocyte development: overview. (2008) (9)
Activation of T lymphocytes to M locus determinants in vivo.. I. Quantitation of T cell proliferation and migration into thoracic duct lymph (1976) (9)
Positive and negative selection in Basel (2008) (9)
Thoracic Thymus, Exclusive No Longer (2006) (8)
Direct cell contact is required in the syngeneic mixed lymphocyte reaction. (1973) (8)
Some requirements for the response of separated T-cell sub-populations to the mitogens phytohaemagglutinin and concanavalin A. (1977) (8)
Kinetics of negative and positive selection in the thymus. (1991) (8)
Control of T-cell Development by the TCRαβ for Antigen (1989) (8)
Positive Selection by the Pre-TCR Yields Mature CD8+ T Cells1 (2002) (8)
Regulatory T cells and antigen-specific tolerance. (2008) (8)
Peripheral tolerance and organ specific autoimmunity. (2001) (7)
Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212. (2009) (7)
Multiplication of lymphocytic choriomeningitis virus in cultivated foetal inbred mouse cells and in neonatally infected inbred carrier mice. (1974) (7)
Control of T-cell development by the pre-T and alpha beta T-cell receptor. (1995) (7)
Notch in lymphopoiesis and T cell polarization (2005) (7)
Thymocyte Selection: Chemokine Signaling Is Not Only about the Destination (2010) (7)
Notch in lymphopoiesis and T cell polarization (2005) (7)
Maturation of fetal thymocytes in organ culture: secretion of interleukin 2, interferon and colony stimulating factors. (1985) (7)
T cell repertoire selection in T cell receptor transgenic mice. (1988) (6)
Hapten‐specific helper T cells III. Fine specificity of the (4‐hydroxy‐3‐nitro‐phenyl)‐acetyl (NP)‐specific response in Igh‐1b mice (1981) (6)
Cell-Mediated Cytotoxicity (2020) (6)
Positive and negative selection of the alpha beta T-cell repertoire in vivo. (1991) (6)
Hemopoietic reconstitution obtained in F1 hybrids by grafting of parental marrow cells. (1976) (6)
The influence of H-2 gene products on cell-mediated and humoral immune responses. (1977) (6)
T cell clones (1985) (6)
T-cell development in the absence of the pre-T-cell receptor. (1997) (5)
T cell differentiation: control by the pre-TCR and αβ TCR (1995) (5)
Induction of tolerance in immature and mature T cells. (1993) (5)
T cell receptor beta chain dimers on immature thymocytes from normal mice. (1993) (4)
Selective stimulation by B lymphocytes in the syngeneic mixed lymphocyte reaction (1974) (4)
Self recognition by the immune system. (1990) (4)
The differentiation of T lymphocytes. Density characterisation of thymic and peripheral T cells responding in syngeneic and allogenic mixed lymphocyte reactions. (1975) (4)
Type 1 diabetes: focus on prevention (2004) (4)
Deciphering Thymic Development (2014) (4)
Deciphering Thymic Development (2014) (4)
Learning by the immune system studied in T-cell receptor transgenic mice. (1989) (4)
Control of T-cell development by the TCR alpha beta for antigen. (1989) (4)
T cell clones: Their use for the study of specificity, induction, and effector-function of T cells (1980) (3)
that can give rise to diff erent lineages of αβ T cells (2006) (3)
Can studies of tolerance ever lead to therapy? (2006) (3)
Stimulation of mouse thymocytes by syngeneic spleen cells in mixed lymphocyte reactions. (1973) (3)
T-call development: is notch a key player in lineage decisions? (1997) (3)
Notch 1 keeps pro-T cells on track. (2009) (3)
Female anti-male attack (1995) (3)
Immunology. Thoracic thymus, exclusive no longer. (2006) (3)
Shaping the T cell repertoire. (2006) (3)
Central tolerance: Essential for preventing autoimmune disease? (2009) (3)
Notch 1 keeps pro-T cells on track. (2009) (3)
Immune Response Regulation (2006) (3)
FoxP3 and Regulatory T Cells (2008) (3)
Cytotoxic T cell responses to haptenated cells IV. Requirements for in vivo priming (1984) (3)
T-cell development: What does Notch do for T cells? (1999) (3)
The manipulation of immunity (2004) (2)
Self-Nonself Discrimination by the Immune System (1989) (2)
The manipulation of immunity. Conference on from allergy to cancer: new perspectives for therapeutic vaccination. (2004) (2)
Thymus development. (1986) (2)
Immunology. Tolerance by exhaustion. (1993) (2)
Different T cell receptors in the development of pre-T cells (1997) (2)
Five types of lymphocytes (Ig-theta-, Ig-theta+weak, Ig-theta+strong, Ig+theta- and Ig+theta+) characterized by double immunofluorescence and electrophoretic mobility. Organ distribution in normal and nude mice. (1975) (2)
Immunohistology of T cell differentiation in the thymus of H-Y-specific T cell receptor alpha/beta transgenic mice. (1990) (2)
Cytolytic T-cell clones and hybridomas. (1986) (2)
17 – Cytolytic T Cell Clones and Hybridomas (1985) (2)
How Essential is the Pre-T-Cell Receptor? (1998) (2)
Selection of the T-cell repertoire during ontogeny. (1983) (2)
Direct cell contact is required in the syngeneic mixed lymphocyte reaction (1973) (2)
Can studies of tolerance ever lead to therapy (2006) (2)
TCR α-Chain Repertoire in pTα-Deficient Mice Is Diverse and Developmentally Regulated: Implications for Pre-TCR Functions and TCRA Gene Rearrangement (1999) (2)
H-2 Linked Responsiveness Is Acquired by Low Responder Lymphocytes Differentiating in the Thymus of High Responders (1978) (2)
Self–Nonself Discrimination by T Lymphocytes (1993) (2)
H‐2D products do not affect lysis of Kk target cells by Kk‐specific cytotoxic T cells (1983) (2)
-Catenin stabilization stalls the transition from Double Positive to Single Positive stage and predisposes thymocytes to malignant transformation. Stabilization of β -catenin induces lymphomas (2007) (1)
Role of the thymus in the acquisition of immunologic self-tolerance. (1993) (1)
The Thymus in Immunity and in Malignancy (2014) (1)
Immunological Tolerance (2010) (1)
T Cell Proliferation and Differentiation (1985) (1)
Shaping the T Cell Repertoire1 (2006) (1)
FURTHER EVIDENCE FOR CLONAL DELETION OF HOST REACTIVE T CELLS IN X-IRRADIATION CHIMERAS (1976) (1)
Shaping the T Cell Repertoire (2005) (1)
Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes” (2017) (1)
Developmental biology of T lymphocytes. Deletion of autoreactive T cells and impact of the alpha, beta receptor on the CD4/CD8 phenotype. (1988) (1)
Intrathymic Selection and Maturation of αβ T Cells (1993) (1)
The manipulation of immunity 89th International Titisee Conference »From allergy to cancer: new perspectives for therapeutic vaccination« (2004) (1)
[Cold-antibodies in rat serum against Yoshida-hepatom ascites cells]. (1972) (1)
Preservation of cloned T cells cytotoxic for male-antigen-bearing target cells (1979) (1)
Early T Cell Receptor (cid:98) Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex (1999) (1)
Corrigendum: Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes (2004) (1)
Lymphocyte development essential features. (1997) (1)
T cell hybridomas. A workshop at the Basel Institute for Immunology. (1982) (1)
T cell differentiation: control by the pre-TCR and alpha beta TCR. (1995) (1)
Shaping the T Cell Repertoire 1 (2005) (1)
T CELL DEVELOPMENT IN T CELL RECEPTOR TRANSGENIC MICE (1990) (1)
Learning by the immune system studied in T-cell receptor transgenic mice. (1989) (1)
The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia (2012) (0)
Peptide‐Based Instruction of Suppressor Commitment in Naïve T Cells and Dynamics of Immunosuppression in vivo (2005) (0)
Ir genes of the major histocompatibility complex (1984) (0)
Faculty Opinions recommendation of γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. (2012) (0)
Chapter 2 FoxP 3 and Regulatory T Cells (2009) (0)
Helper cell-independent clonal expansion of H-2D-restricted cytolytic T cells. (1984) (0)
Faculty Opinions recommendation of T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. (2012) (0)
Faculty Opinions recommendation of The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus. (2004) (0)
Tolerance induction in mature CD4+ T cells (1997) (0)
Faculty Opinions recommendation of Intraclonal competition limits the fate determination of regulatory T cells in the thymus. (2009) (0)
Thoracic Thymus, Exclusive No Longer (2006) (0)
Mechanisms of beta cell death in autoimmune diabetes (1997) (0)
Faculty Opinions recommendation of Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. (2004) (0)
Prevention of type 1 diabetes. (2004) (0)
Female anti-male attack (1995) (0)
CHAPTER 10 – Peptide-Based Instruction of Suppressor Commitment in Naïve T Cells (2006) (0)
Allelic Exclusion in pT (cid:97) -deﬁcient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)- (cid:98) Chains, but Less Efﬁcient Inhibition of Endogeneous V Rearrangements in the Presence of a Functional TCR- (cid:98) Transgene (1997) (0)
Table of Contents (1987) (0)
Rapid Publication Antigen-Specific FoxP3-Transduced T-Cells Can Control Established Type 1 Diabetes (2005) (0)
Autoimmunity: 2000 and Beyond, Newport Beach, California, February 11–13, 2000 (2004) (0)
Self recognition by the immune system. (1990) (0)
Immunogenetics. Female anti-male attack. (1995) (0)
Correction (1988) (0)
Genetic Origins of B and T Cell Antibodies (1983) (0)
[Binding of a fraction from human Ig-G-globulin to the membrane of L cells, Zajdela and Yoshida ascites cells]. (1969) (0)
progression c-Myc mediates pre-TCR-induced proliferation but not developmental (2013) (0)
Thymus and autoimmunity (2003) (0)
Meeting calender November 2003 (2003) (0)
The utilization of the scid mutation in the study of T cell development. (1989) (0)
[On the effect of factors from human serum on the electrophoretic mobility of mammalian cells]. (1968) (0)
Dynamics of Suppressor T Cells (2003) (0)
Self-Nonself Discrimination by Developing and Mature T Cells (1993) (0)
Ontogeny of T Cell Receptors for Antigen (1986) (0)
Induction in vitro. I. Evidence for genetic restric- tion of t cell-macrophage interactions prior to t cell priming. (1978) (0)
Immunity Previews Notch 1 Keeps ProT Cells on Track (2009) (0)
TOLERANCE INDUCTION TOWARDS DETERMINANTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX: EVIDENCE FOR DELETION OF T CELL SUBSETS (1975) (0)
Immune response regulation. (1982) (0)
Lymphocyte development Commitment, selection and switching (2000) (0)
Faculty Opinions recommendation of Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. (2002) (0)
Faculty Opinions recommendation of Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. (2001) (0)
Positive and negative selection in Basel. (2008) (0)
Exclusion and Inclusion of α and β T Cell Receptor Alleles in Different T Cell Lineages (1993) (0)
Control of T cell development by the αß T cell receptor for antigen (1989) (0)
Cryopreservation of cytotoxic T-cell clones and their targets (1980) (0)
Lymphocyte development. (1993) (0)
A POSSIBLE FUNCTION FOR PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN HUMORAL IMMUNITY (1976) (0)
Faculty Opinions recommendation of Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. (2003) (0)
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version (2006) (0)
Reversible control of CD8 cytotoxicity by regulatory T cells (2006) (0)
[Experiments on rats for finding out the immune response to a Yoshida hepatoma ascites transplant]. (1972) (0)
T-cell lineage fate: instructed by receptor signals? (2000) (0)
Histocompatibility Antigens and the T-Cell Repertoire (1981) (0)
Ontogenic aspects of the syngeneic mixed leukocyte reaction. (1983) (0)
[Relation between the cytotoxic and electrokinetic effect of human serum on L cells and Yoshida hepatoma ascites cells]. (1970) (0)
WITHDRAWN: Lymphocyte development. Overview (2008) (0)
Peripheral T cell survival requires the presence of selecting MHC molecules (1997) (0)
Review Self recognition by the immune system (1990) (0)
[Acute effect of air pollutants on the lung and respiratory tract of persons at-risk]. (1987) (0)
T cell receptor – instructed (cid:6) (cid:3) versus (cid:5) (cid:4) lineage commitment revealed by single-cell analysis (2008) (0)
Meeting Calender July 2003 (2003) (0)
Autoimmunity: 2000 and Beyond, Newport Beach, California, February 11–13, 2000 (2004) (0)
T Cells CD8 and + Class II Hemagglutinin Peptide in CD4 Mice Expressing a TCR Receptor Specific for Against Influenza Virus Infection in Transgenic Cellular Mechanisms Involved in Protection (1998) (0)
Correction: Monitoring gene expression of TNFR family members by β-cells during development of autoimmune diabetes (Eur. J. Immunol. 7/2003) (2003) (0)

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