Harald Wajant
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(Suggest an Edit or Addition)Harald Wajant's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Tumor necrosis factor signaling (2003) (2387)
- The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor (1995) (1374)
- The Fas Signaling Pathway: More Than a Paradigm (2002) (947)
- NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling (2001) (661)
- The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. (1998) (480)
- The CD95 Receptor: Apoptosis Revisited (2007) (403)
- The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. (2001) (379)
- Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF‐R1 activation by endogenous membrane‐anchored TNF (1999) (303)
- Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. (2002) (289)
- Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis (2000) (264)
- NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP (2004) (258)
- Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. (2008) (236)
- TNFR1‐induced activation of the classical NF‐κB pathway (2011) (227)
- TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma (2006) (217)
- Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative (2001) (215)
- Non-apoptotic Fas signaling. (2003) (207)
- Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site. (1997) (197)
- Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD)* (2000) (190)
- The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-κB and c-Jun N-terminal Kinase* (1999) (190)
- TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages (2019) (182)
- Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling. (2001) (181)
- Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)* (2009) (163)
- The Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors TRAIL-R1 and TRAIL-R2 Have Distinct Cross-linking Requirements for Initiation of Apoptosis and Are Non-redundant in JNK Activation* (2000) (161)
- TWEAK can induce cell death via endogenous TNF and TNF receptor 1 (1999) (154)
- Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction (1998) (151)
- TRAIL/Apo2L Activates c-Jun NH2-terminal Kinase (JNK) via Caspase-dependent and Caspase-independent Pathways* (1998) (150)
- Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1 (1998) (148)
- TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60. (1998) (146)
- Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation (2018) (143)
- TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy (2002) (142)
- Tumor therapeutics by design: targeting and activation of death receptors. (2005) (136)
- Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand1 (2009) (127)
- Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions. (2006) (123)
- Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion (2016) (123)
- p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells (2001) (115)
- The role of TNF in cancer. (2009) (114)
- Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. (2014) (113)
- Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L (2007) (110)
- A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death (2011) (108)
- Selective Inhibition of FLICE-like Inhibitory Protein (FLIP) Expression With Small Interfering RNA Oligonucleotides (siRNAs) Is Sufficient to Sensitize Tumor Cells for TRAIL-Induced Apoptosis (2002) (108)
- The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability (2005) (104)
- TNF receptor associated factors in cytokine signaling. (1999) (100)
- Principles of antibody-mediated TNF receptor activation (2015) (95)
- Cellular FLICE-inhibitory Protein (cFLIP) Isoforms Block CD95- and TRAIL Death Receptor-induced Gene Induction Irrespective of Processing of Caspase-8 or cFLIP in the Death-inducing Signaling Complex* (2011) (93)
- Tumor Necrosis Factor Receptor-associated Factor (TRAF) 1 Regulates CD40-induced TRAF2-mediated NF-κB Activation* (2004) (93)
- Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF-κB Pathway (2010) (92)
- CD95 and TRAF2 promote invasiveness of pancreatic cancer cells (2005) (90)
- Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma (2008) (88)
- Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. (2013) (88)
- Astrocyte‐specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor (2014) (87)
- TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5 (2010) (84)
- Characterization and synthetic applications of recombinant AtNIT1 from Arabidopsis thaliana. (2002) (84)
- Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target (2019) (83)
- Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell-surface Antigen-restricted Activation* (2003) (82)
- Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation (2009) (80)
- Hydroxynitrile lyases of higher plants. (1996) (77)
- The First Recombinant Hydroxynitrile Lyase and its Application in the Synthesis of (S)‐Cyanohydrins (1996) (77)
- Rocaglamide Derivatives Are Potent Inhibitors of NF-κB Activation in T-cells* (2002) (75)
- CD95L/FasL and TRAIL in tumour surveillance and cancer therapy. (2006) (75)
- TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling (2009) (74)
- Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes. (1998) (73)
- The TWEAK‐Fn14 system as a potential drug target (2013) (73)
- Caspase‐induced inactivation of the anti‐apoptotic TRAF1 during Fas ligand‐mediated apoptosis (2000) (73)
- Superior serum half life of albumin tagged TNF ligands. (2010) (72)
- Fas-associated Death Domain Protein (FADD) and Caspase-8 Mediate Up-regulation of c-Fos by Fas Ligand and Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) via a FLICE Inhibitory Protein (FLIP)-regulated Pathway* (2001) (70)
- Hydroxynitrile lyases in stereoselective catalysis. (2000) (69)
- Targeting the FLICE Inhibitory Protein (FLIP) in cancer therapy. (2003) (69)
- ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade (2014) (68)
- Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis. (2002) (65)
- Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing (2005) (64)
- Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins (2010) (63)
- Engineering death receptor ligands for cancer therapy. (2013) (63)
- The IKK Inhibitor Bay 11-7082 Induces Cell Death Independent from Inhibition of Activation of NFκB Transcription Factors (2013) (62)
- TRAIL and NFκB Signaling—a Complex Relationship (2004) (62)
- SMAC Mimetic BV6 Induces Cell Death in Monocytes and Maturation of Monocyte-Derived Dendritic Cells (2011) (60)
- TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms (2011) (60)
- The role of FasL and Fas in health and disease. (2009) (59)
- Identification of Potential Active-site Residues in the Hydroxynitrile Lyase from Manihot esculenta by Site-directed Mutagenesis* (1996) (59)
- Cell death‐independent activities of the death receptors CD95, TRAILR1, and TRAILR2 (2017) (58)
- Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization (2008) (57)
- Molecular cloning of hydroxynitrile lyase from Sorghum bicolor (L.). Homologies to serine carboxypeptidases (1994) (56)
- Substrate Specificity of Mutants of the Hydroxynitrile Lyase from Manihot esculenta (2003) (55)
- Identification of a TRAF (TNF Receptor-Associated Factor) Gene in Caenorhabditis elegans (1998) (53)
- Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4). (2002) (53)
- Purification and Characterization of a Novel (R)-Mandelonitrile Lyase from the Fern Phlebodium aureum (1995) (52)
- Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)* (2011) (52)
- Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells. (2007) (52)
- Therapeutic targeting of CD70 and CD27 (2016) (51)
- Molecular Cloning of Acetone Cyanohydrin Lyase from Flax (Linum usitatissimum) (1997) (51)
- Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis (2016) (50)
- Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists. (2008) (50)
- Sustained JNK Activation in Response to Tumor Necrosis Factor Is Mediated by Caspases in a Cell Type-specific Manner* (2007) (49)
- Continuous Autotropic Signaling by Membrane-expressed Tumor Necrosis Factor* (1999) (48)
- Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug (2006) (46)
- Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation (2010) (45)
- Apoptosis is not required for acantholysis in pemphigus vulgaris. (2009) (45)
- TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis (2014) (45)
- Caspase-mediated Cleavage Converts the Tumor Necrosis Factor (TNF) Receptor-associated Factor (TRAF)-1 from a Selective Modulator of TNF Receptor Signaling to a General Inhibitor of NF-κB Activation* (2003) (45)
- Fibroblast Growth Factor Inducible (Fn14)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity* (2013) (44)
- Binding Studies of TNF Receptor Superfamily (TNFRSF) Receptors on Intact Cells* (2015) (44)
- Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells (2020) (44)
- Hydroxynitrile lyase from Sorghum bicolor: a glycoprotein heterotetramer (1993) (44)
- Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with the inhibitor benzoic acid: a novel cyanogenic enzyme. (2002) (41)
- Activation of CD95L fusion protein prodrugs by tumor-associated proteases (2007) (41)
- Principles and mechanisms of CD95 activation (2014) (40)
- Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation. (2004) (40)
- Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta (2002) (40)
- Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells. (2017) (40)
- Death receptors. (2003) (38)
- Acetone cyanohydrin lyase from Manihot esculenta (cassava) is serologically distinct from other hydroxynitrile lyases (1995) (36)
- Activated CD8+ T Cells Induce Expansion of Vβ5+ Regulatory T Cells via TNFR2 Signaling (2014) (36)
- Tumor necrosis factor receptor family costimulation increases regulatory T‐cell activation and function via NF‐κB (2020) (36)
- Expression of Tumor Necrosis Factor Receptor 2 Characterizes TLR9-Driven Formation of Interleukin-10-Producing B Cells (2018) (34)
- Structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: implications for the mechanism of cyanogenesis. (2000) (33)
- Tumor Necrosis Factor (TNF) and Phorbol Ester Induce TNF-related Apoptosis-inducing Ligand (TRAIL) under Critical Involvement of NF-κB Essential Modulator (NEMO)/IKKγ* (2001) (33)
- Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development (2001) (33)
- Mechanistic aspects of cyanogenesis from active‐site mutant Ser80Ala of hydroxynitrile lyase from Manihot esculenta in complex with acetone cyanohydrin (2001) (33)
- Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling (2019) (32)
- Endogenous Membrane Tumor Necrosis Factor (TNF) Is a Potent Amplifier of TNF Receptor 1-mediated Apoptosis* (2002) (31)
- CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants (2014) (31)
- Expression of the Zn2+-containing hydroxynitrile lyase from flax (Linum usitatissimum) in Pichia pastoris— utilization of the recombinant enzyme for enzymatic analysis and site-directed mutagenesis (1998) (31)
- Targeted cancer immunotherapy using ligands of the tumor necrosis factor super-family. (2009) (31)
- Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis (2012) (30)
- Bioactive Brominated Oxindole Alkaloids from the Red Sea Sponge Callyspongia siphonella (2019) (30)
- Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD. (2015) (30)
- Immunocytological localization of hydroxynitrile lyases from Sorghum bicolor L. and Linum usitatissimum L (1994) (29)
- Molecular Mode of Action of TRAIL Receptor Agonists—Common Principles and Their Translational Exploitation (2019) (29)
- Tumor necrosis factors in 1996. (1996) (29)
- Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice (2018) (28)
- Summary Apoptotic crosstalk of TNF receptors : TNF-R 2-induces depletion of TRAF 2 and IAP proteins and accelerates TNF-R 1-dependent activation of caspase-8 (28)
- Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily (2021) (28)
- On-target restoration of a split T cell-engaging antibody for precision immunotherapy (2019) (28)
- Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. (2002) (28)
- Purification and characterization of hydroxynitrile lyase from Hevea brasiliensis (1996) (28)
- Oligomerized tumor necrosis factor‐related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways (2009) (27)
- TRAIL and NFkappaB signaling--a complex relationship. (2004) (26)
- Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (2020) (25)
- Therapeutic targeting of CD95 and the TRAIL death receptors. (2011) (25)
- A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo (2014) (25)
- CD40-directed scFv-TRAIL fusion proteins induce CD40-restricted tumor cell death and activate dendritic cells (2013) (25)
- Tumor Necrosis Factor Induces Tumor Promoting and Anti-Tumoral Effects on Pancreatic Cancer via TNFR1 (2013) (25)
- Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface (2006) (25)
- Signaling Active CD95 Receptor Molecules Trigger Co-translocation of Inactive CD95 Molecules into Lipid Rafts* (2012) (25)
- TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity (2019) (24)
- Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33-34. (1997) (24)
- TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis (2014) (24)
- Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values (2008) (24)
- [Biofabrication: new approaches for tissue regeneration]. (2018) (24)
- New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67 (2018) (23)
- Tumor necrosis factors in 1998. (1998) (22)
- Soluble TL1A is sufficient for activation of death receptor 3 (2016) (22)
- Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells (2021) (22)
- MLN4924 sensitizes monocytes and maturing dendritic cells for TNF‐dependent and ‐independent necroptosis (2015) (22)
- Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer (2019) (22)
- Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death (2014) (21)
- XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis (2014) (21)
- Analogies between Drosophila and mammalian TRAF pathways. (2004) (20)
- Improving TNF as a cancer therapeutic: Tailor‐made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects (2009) (20)
- A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus. (2019) (19)
- Characterization of different soluble TNF receptor (TNFR80) derivatives: positive influence of the intracellular domain on receptor/ligand interaction and TNF neutralization capacity. (1996) (19)
- A CD40–CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95 (2006) (19)
- TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP (2019) (18)
- Multimodal Bioactivation of Hydrophilic Electrospun Nanofibers Enables Simultaneous Tuning of Cell Adhesivity and Immunomodulatory Effects (2017) (18)
- TWEAK Inhibits TRAF2-Mediated CD40 Signaling by Destabilization of CD40 Signaling Complexes (2013) (18)
- The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death (2019) (15)
- TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK (2014) (14)
- Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling. (2011) (14)
- Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies (2018) (13)
- Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands. (2009) (13)
- Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation (2017) (13)
- Purification of hydroxynitrile lyase from Sorghum bicolor L. (sorghum) by affinity chromatography using monoclonal antibodies (1993) (13)
- Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice (2021) (13)
- A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models (2021) (13)
- Crystallization and preliminary x-ray diffraction analysis of hydroxynitrile lyase from cassava (Manihot esculenta). (1999) (12)
- Exogenous Administration of a Recombinant Variant of TWEAK Impairs Healing after Myocardial Infarction by Aggravation of Inflammation (2013) (12)
- TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling (2018) (11)
- TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling (2019) (11)
- Enantioselective Synthesis of Aliphatic (S)‐Cyanohydrins in Organic Solvents Using Hydroxynitrile Lyase from Manihot esculenta (1996) (11)
- Tumor necrosis factor (TNF) and phorbol ester induce TNF-related apoptosis-inducing ligand (TRAIL) under critical involvement of NF-kappa B essential modulator (NEMO)/IKKgamma. (2001) (11)
- Production, purification, and characterization of scFv TNF ligand fusion proteins. (2012) (10)
- Increasing complexity in TNFR1 signaling (2011) (10)
- Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis (2018) (10)
- Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling (2020) (10)
- Quantitative analysis of cell surface antigen-antibody interaction using Gaussia princeps luciferase antibody fusion proteins (2017) (10)
- TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer (2022) (9)
- Assessment of TP53 lesions for p53 system functionality and drug resistance in multiple myeloma using an isogenic cell line model (2019) (9)
- Integrin-linked kinase is dispensable for multiple myeloma cell survival. (2012) (9)
- Targeting of the WT191–138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination (2017) (9)
- E3-14.7K Is Recruited to TNF-Receptor 1 and Blocks TNF Cytolysis Independent from Interaction with Optineurin (2012) (8)
- Analyzing the signaling capabilities of soluble and membrane TWEAK. (2014) (8)
- Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors (2018) (8)
- Cloning of a cDNA encoding a new ribosome-inactivating protein from Beta vulgaris vulgaris (mangold). (1996) (8)
- TNFR-Associated Factor 2 and Is Specific for TNFR 60-Induced Cell Death Is Mediated by TNFR 80-Dependent Enhancement of Scheurich and (1998) (7)
- The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent (2017) (6)
- A systems-biology model of the tumor necrosis factor (TNF) interactions with TNF receptor 1 and 2 (2020) (6)
- CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism (2022) (6)
- A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model (2022) (6)
- A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity (2022) (5)
- CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism (2020) (5)
- Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist (2021) (4)
- TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different (2017) (4)
- Targeted delivery of CD 40 L promotes restricted activation of antigen-presenting cells and induction of cancer cell (2018) (4)
- Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy (2022) (4)
- Generation and Application of Bioluminescent CD95 Ligand Fusion Proteins. (2017) (4)
- Signaling Profile and Anti-Tumor Activity of the Novel HSP90 Inhibitor NVP-AUY922 in Multiple Myeloma. (2007) (4)
- Enhanced basal AP‐1 activity and de‐regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1 (2004) (3)
- The FasL-Fas Signaling Network (2003) (2)
- Anti-Fn14 Antibody-Conjugated Nanoparticles Display Membrane TWEAK-Like Agonism † (2021) (2)
- TNFR2 induced priming of NLRP3-inflammasome via RIPK1 leads to pyroptosis in XIAP deficient cells (2019) (2)
- A Selective TNFR2 Agonist Expands Host Treg Cells in Vivo to Protect from Acute Graft-Versus-Host Disease (2014) (2)
- Genetic engineering of death ligands for improvement of therapeutic activity. (2011) (2)
- Crystallographic studies and preliminary X-ray investigation of (S)-p-hydroxy-mandelonitrile lyase from Sorghum bicolor (L.). (1996) (2)
- Targeting fibroblast growth factor (FGF)-inducible 14 (Fn14) for tumor therapy (2022) (2)
- Towards the future of plastic surgery: from flaps to microsurgery and regenerative medicine and biofabrication? (2017) (2)
- Development of Anti-TNFR Antibody-Conjugated Nanoparticles (2020) (1)
- Author response for "Tumor necrosis factor receptor family co‐stimulation increases regulatory T cell activation and function via NF‐κB" (2019) (1)
- Analysis of FcγR-Dependent Agonism of Antibodies Specific for Receptors of the Tumor Necrosis Factor (TNF) Receptor Superfamily (TNFRSF). (2021) (1)
- No RISC, no fun: assembly of receptor-induced signalling complexes in the tumor necrosis factor system. (2000) (1)
- Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling (2023) (1)
- TNFR2 Is Expressed Preferentially By Late Differentiated CD8 T-Cells and Can be Triggered By TNFR2-Specific Ligand to Induce Cell Death of Recently Activated Antigen-Specific T Cells: A Possible Role of TNFR2 in T-Cell Deflation (2014) (1)
- Interferons induce proteolytic degradation of TRAILR4. (2005) (1)
- FcγRs and Their Relevance for the Activity of Anti-CD40 Antibodies (2022) (0)
- Recombinant Spider Silk Bioinks for Continuous Protein Release by Encapsulated Producer Cells. (2022) (0)
- RETRACTED ARTICLE: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (2020) (0)
- Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP (2020) (0)
- CD40-Licensing Of Human Dendritic Cells Further Matures Tnfa-Treated Dcs But Does Not Mediate Resistance Against Inhibition Of T-Cell Proliferation By TREG (2013) (0)
- Medicament to increase the efficacy of a receptor-mediated triggering apoptosis in tumor cells the drug (2002) (0)
- Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis (2018) (0)
- Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling (2019) (0)
- Unchanged pancreatic beta-cell phenotype, function and sensitivity to cytokine-induced apoptosis in GAD-65 autoantigen-suppressed INS-1 cells (2004) (0)
- Correction: Binding studies of TNF receptor superfamily (TNFRSF) receptors on intact cells. (2020) (0)
- Mathematical Modeling of TNF Receptor Interaction (2000) (0)
- A process for the preparation of (S) -cyanhydriner (1997) (0)
- Erratum to: TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5 (2011) (0)
- 1079 TNF-TNFR Interactions Influence Tumor Growth and Metastasis by Manipulating Regulatory T Cell Homeostasis (2012) (0)
- [From tumor necrosis factor to TRAIL-AMAIZe: second generation antitumorally effective cytokines]. (2001) (0)
- In Vivo Bioluminescence Imaging to Study the Contribution of TNF-TNFR Interactions on Immune and Parenchymal Cells to Tumor Cell Progression in a Syngenic Mouse Model (2011) (0)
- Fas—More Than an Apoptosis Inducer (2006) (0)
- University of Groningen Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death (2014) (0)
- Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death (2014) (0)
- Enzyme-Catalyzed Reactions. Part 23. The First Recombinant Hydroxynitrile Lyase and Its Application in the Synthesis of (S)- Cyanohydrins. (1996) (0)
- Abstract # 1766 Myocardial infarction influences microglia morphology in the hypothalamus (2016) (0)
- Anti‐TNF therapy inhibits pancreatic tumor growth and metastasis (2008) (0)
- sensitizes monocytes and maturing dendritic cells for tumor necrosis factor ( TNF )-dependent and-independent necroptosis 1 Running title : MLN 4924 sensitizes myeloid cells for necroptosis (2014) (0)
- Functional titration of MLN4924 and effects on MM cell viability. (2013) (0)
- (S) -hydroxynitrile substance with improved acceptance and use thereof (1999) (0)
- Activation localement specifique, par l'intermediaire d'anticorps, d'une zytokine pro-apoptose : amaize (antibody-mediated apoptosis inducing zytokine) (2001) (0)
- Basic characterization of antibodies targeting receptors of the tumor necrosis factor receptor superfamily (2023) (0)
- The FasL-Fas System in Disease and Therapy (2006) (0)
- Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP (2020) (0)
- Signaling Complexes Signaling by Destabilization of CD40 TWEAK Inhibits TRAF2-Mediated CD40 (2013) (0)
- A process for preparing (S) -cyanohydrins (1997) (0)
- Molecular profile and anti-myeloma activity of the novel Hsp90 inhibitor NVP-AUY922 (2008) (0)
- Phylogeny and catalytic mechanism of hydroxynitrile lyases (1996) (0)
- Harnessing the Expression of TNFR2 on Tregs to Prevent Agvhd (2022) (0)
- Anticorps dirigés contre cd70 (2012) (0)
- Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice (2018) (0)
- Activation mediated proapoptotic cytokine specific antibodies to the site; AMAIZe (apoptosis-inducing cytokines antibody mediated) (2001) (0)
- Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (2021) (0)
- A process for the preparation of hydroxynitril lyases (2000) (0)
- Development of anti-TNFRSF-conjugated nanoparticle and in vitro evaluation of its immunostimulatory effect. (2020) (0)
- Abstract 117: TWEAK (Tumor Necrosis Factor-Like Weak Inducer of Apoptosis) Impedes Healing After Myocardial Infarction in Mice (2012) (0)
- PS1001 HACE1, A NOVEL TUMOR SUPPRESSOR GENE WHICH REGULATE THE RESPONSE OF VENETOCLAX, GANT61 AND NECROPTOSIS ACTIVATORS BY CONTROLLING C-FLIP, GLI2 AND BCL2 GENES IN ACUTE MYELOID LEUKEMIA (2019) (0)
- Separation of GvH- and GvL-Immune Responses in Allogeneic Stem Cell Transplantation by CD95-Mediated Depletion of Alloreactive T-Cells Using CD178 Based Proapoptotic Chimeric Molecules. (2004) (0)
- Targeted local activation of Fas in pancreatic beta cells for treatment of insulinomas and disorders of pathological autonomic insulin secretion (2005) (0)
- TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity (2019) (0)
- ON THE MECHANISM OF CYANOGENESIS CATALYZED BY HYDROXYNITRILE LYASE FROM MANIHOT ESCULENTA. CRYSTAL STRUCTURE OF ACTIVE SITE MUTANT SER80ALA IN COMPLEX WITH ACETONE CYANOHYDRIN (2001) (0)
- B213 Integrin-linked Kinase as a Target in Multiple Myeloma (2009) (0)
- TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling (2018) (0)
- Abstract 14173: Depletion of Neutrophils Ablates Cardiac Ruptures after Treatment with TWEAK (Tumor Necrosis Factor-Like Weak Inducer of Apoptosis) in a Mouse Model of Myocardial Infarction (2012) (0)
- Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation (2009) (0)
- Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma (2021) (0)
- (S) -hydroxynitrillyaser with improved substratacceptans and the use thereof (1999) (0)
- TG-3-7 Anti-TNF therapy inhibits pancreatic tumor growth and metastasis(Biliary tract, Pancreas,Travel Grant) (2009) (0)
- CD40-licensing of human dendritic cells increases T-cell stimulatory capacity and mediates resistance against treg-induced downregulation of costimulatory molecules (2013) (0)
- Ligand and Glucocorticoid-Induced TNF Receptor Soluble Trimers of CD 27 L , CD 40 L , 41 BBL , Immobilization Improve the Activity of Antibody-Mediated Cell Surface Trimer Stabilization , Oligomerization , and Wajant (2009) (0)
- Analysis of Ligand-Receptor Interactions Using Bioluminescent TNF Superfamily (TNFSF) Ligand Fusion Proteins. (2021) (0)
- Mechanisms of Tumor Necrosis Factor‐induced Cell Death (2008) (0)
- The HACE1-NRF2 Axis a Novel Target in Acute Myeloid Leukemia (2018) (0)
- Evaluation of Different Co-Stimulatory Signals in the Priming and Expansion of HLA-B*0702/CMV_pp65 Restricted CTLs after Stimulation with aAPC (2008) (0)
- Altered Microglia Morphology in The Hypothalamus after Myocardial Infarction in Mice (2016) (0)
- Interleukin-1 Receptor/Toll-Like Receptor Signaling (2005) (0)
- Abstract 1438: TNF-TNFR interactions influence tumor growth and metastasis by manipulating regulatory T cell homeostasis. (2013) (0)
- Crystal Structure of Hydroxynitrile Lyase from Manihot esculenta at 2.2 Angstrom Resolution (2000) (0)
- Novel TRAIL variants for targeted cancer therapy. (2010) (0)
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What Schools Are Affiliated With Harald Wajant?
Harald Wajant is affiliated with the following schools:
