Harley McAdams
American physicist, microbial geneticist, and developmental biologist
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Biology
Why Is Harley McAdams Influential?
(Suggest an Edit or Addition)According to Wikipedia, Harley H. McAdams is an American physicist, microbial geneticist, and developmental biologist. McAdams and his collaborators have published foundational insights on the nature of genetic regulatory logic and cell biology, the molecular basis for inevitable random variation levels of protein production between different cells, and genetic logic circuits that control the bacterial cell cycle. McAdams is married to Lucy Shapiro. They were jointly awarded the 2009 John Scott Medal for “bringing the methods of electrical circuit analysis to the description of genetic networks of the simple bacterium Caulobacter.”
Harley McAdams's Published Works
Published Works
- Stochastic mechanisms in gene expression. (1997) (1894)
- Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells. (1998) (1641)
- It's a noisy business! Genetic regulation at the nanomolar scale. (1999) (885)
- Circuit simulation of genetic networks. (1995) (550)
- Global analysis of the genetic network controlling a bacterial cell cycle. (2000) (520)
- Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication. (2004) (418)
- Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle (2002) (369)
- Graemlin: general and robust alignment of multiple large interaction networks. (2006) (355)
- Codon usage between genomes is constrained by genome-wide mutational processes. (2004) (322)
- Simulation of prokaryotic genetic circuits. (1998) (317)
- The essential genome of a bacterium (2011) (287)
- Whole-Genome Transcriptional Analysis of Heavy Metal Stresses in Caulobacter crescentus (2005) (256)
- Why and How Bacteria Localize Proteins (2009) (254)
- Generating and Exploiting Polarity in Bacteria (2002) (240)
- The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation. (2011) (210)
- Oscillating Global Regulators Control the Genetic Circuit Driving a Bacterial Cell Cycle (2004) (205)
- Continuous Particle Separation Through Deterministic Lateral Displacement (2004) (197)
- A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression. (2006) (185)
- A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space (2003) (170)
- A Dynamically Localized Protease Complex and a Polar Specificity Factor Control a Cell Cycle Master Regulator (2006) (165)
- Caulobacter requires a dedicated mechanism to initiate chromosome segregation (2008) (163)
- High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulons (2007) (161)
- The evolution of genetic regulatory systems in bacteria (2004) (161)
- A DNA methylation ratchet governs progression through a bacterial cell cycle (2007) (152)
- DnaA coordinates replication initiation and cell cycle transcription in Caulobacter crescentus (2005) (137)
- Visualization of the movement of single histidine kinase molecules in live Caulobacter cells. (2004) (134)
- Transcriptional Profiling of Caulobacter crescentus during Growth on Complex and Minimal Media (2004) (132)
- Assembly of the Caulobacter cell division machine (2011) (131)
- The Coding and Noncoding Architecture of the Caulobacter crescentus Genome (2014) (126)
- Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function (2010) (122)
- Systems biology of Caulobacter. (2007) (117)
- The functions of DNA methylation by CcrM in Caulobacter crescentus: a global approach (2014) (113)
- Small non‐coding RNAs in Caulobacter crescentus (2008) (109)
- The Global Regulatory Architecture of Transcription during the Caulobacter Cell Cycle (2015) (100)
- The Caulobacter Tol-Pal Complex Is Essential for Outer Membrane Integrity and the Positioning of a Polar Localization Factor (2010) (100)
- Gene regulation: Towards a circuit engineering discipline (2000) (98)
- Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycle (2013) (89)
- Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter (2003) (87)
- Conserved modular design of an oxygen sensory/signaling network with species-specific output (2005) (81)
- Cytokinesis signals truncation of the PodJ polarity factor by a cell cycle‐regulated protease (2006) (75)
- Distinct Constrictive Processes, Separated in Time and Space, Divide Caulobacter Inner and Outer Membranes (2005) (64)
- An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation (2010) (63)
- Regulatory Response to Carbon Starvation in Caulobacter crescentus (2011) (63)
- Architecture and inherent robustness of a bacterial cell-cycle control system (2008) (57)
- Integrated Protein Interaction Networks for 11 Microbes (2006) (52)
- Toggles and oscillators: new genetic circuit designs. (2000) (52)
- System‐level design of bacterial cell cycle control (2009) (50)
- High-throughput identification of protein localization dependency networks (2010) (45)
- Dynamic translation regulation in Caulobacter cell cycle control (2016) (45)
- Towards a circuit engineering discipline. (2000) (44)
- Direct inference of protein–DNA interactions using compressed sensing methods (2011) (30)
- The architecture and conservation pattern of whole-cell control circuitry. (2011) (28)
- Caulobacter chromosome in vivo configuration matches model predictions for a supercoiled polymer in a cell-like confinement (2013) (25)
- Cell cycle progression in Caulobacter requires a nucleoid-associated protein with high AT sequence recognition (2016) (24)
- Setting the pace: mechanisms tying Caulobacter cell-cycle progression to macroscopic cellular events. (2004) (24)
- CauloBrowser: A systems biology resource for Caulobacter crescentus (2015) (23)
- Compaction and transport properties of newly replicated Caulobacter crescentus DNA (2011) (15)
- Dynamic chromosome organization and protein localization coordinate the regulatory circuitry that drives the bacterial cell cycle. (2009) (14)
- Stochastic mechanisms in gene expression (prokaryotic geneticsytranscriptional regulationysimulation of genetic regulationystochastic behavior) (1997) (12)
- A Genetic Oscillator and the Regulation of Cell Cycle Progression in Caulobacter crescentus (2004) (10)
- Dynamic Polarization of Liquid Helium three (1967) (8)
- Dynamic Nuclear Polarization of Liquid Helium-Three by Optical Pumping (1968) (8)
- Bacterial stalks are nutrient-scavenging antennas. (2006) (7)
- Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology? (2011) (6)
- Three enhancements to the inference of statistical protein‐DNA potentials (2013) (6)
- Emerging Non-Volatile Memories (2004) (1)
- Simulating the Pulling of Stalled Elongated Peptide from the Ribosome by the Translocon (2014) (1)
- Dynamic polarization in polymerized alkynes (1964) (0)
- Global Approaches to the Bacterial Cell as an Integrated System (2005) (0)
- Quantifying the Spatial Organization of Bacterial Ribosomes using Three-Dimensional Super-Resolution Microscopy (2014) (0)
- Motion of single MreB bacterial actin proteins in \textit{Caulobacter} show treadmilling in vivo (2006) (0)
- New Liquid 4He Experimental Cryostat (1968) (0)
- Construction of Networks from Diverse Data Sources (2006) (0)
- Quantitative 3D Imaging by Cryo-EM (Shapes, membranes, and mapping of subcellular structures in whole bacteria) (2006) (0)
- Genetic Regulatory Networks: Analysis and Simulation (2003) (0)
- A model for murine layer growth and cell shape during cell division in Caulobacter (2006) (0)
- Elucidating Ribosomal Translocation with Internal Coordinate Flexible Fitting (2014) (0)
- DYNAMIC POLARIZATION OF LIQUID HELIUM-3 BY OPTICAL PUMPING (1967) (0)
- Illuminating complete functional networks: Automation, computation and the single cell (2010) (0)
- Dynamic spatial organization of multi-protein complexes controlling microbial polar organization, chromosome replication, and cytokinesis (2012) (0)
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