Harmit Malik
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Indian American evolutionary biologist
Harmit Malik's AcademicInfluence.com Rankings
Harmit Malikbiology Degrees
Biology
#5170
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#7591
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Evolutionary Biology
#285
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#308
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Biology
Harmit Malik's Degrees
- PhD Molecular and Cell Biology University of California, Berkeley
Why Is Harmit Malik Influential?
(Suggest an Edit or Addition)According to Wikipedia, Harmit Singh Malik is an Indian American evolutionary biologist who is a professor and associate director at the Fred Hutchinson Cancer Research Center. He was awarded the 2022 Genetics Society of America Edward Novitski Prize.
Harmit Malik's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing (2020) (3012)
- The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA (2001) (1092)
- Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain. (2005) (664)
- Phylogenomics of the nucleosome (2003) (597)
- The age and evolution of non-LTR retrotransposable elements. (1999) (556)
- Ancient Adaptive Evolution of the Primate Antiviral DNA-Editing Enzyme APOBEC3G (2004) (474)
- A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing (2020) (456)
- Rules of engagement: molecular insights from host-virus arms races. (2012) (417)
- Poised for contagion: evolutionary origins of the infectious abilities of invertebrate retroviruses. (2000) (322)
- Major Evolutionary Transitions in Centromere Complexity (2009) (316)
- A unified phylogeny-based nomenclature for histone variants (2012) (292)
- Adaptive evolution of Cid, a centromere-specific histone in Drosophila. (2001) (290)
- The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. (2012) (265)
- The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster (2015) (259)
- Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses (2012) (255)
- Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan Taxa (2009) (255)
- Protein kinase R reveals an evolutionary model for defeating viral mimicry (2008) (239)
- Safeguarding gene drive experiments in the laboratory (2015) (234)
- Origins and Evolution of Retrotransposons (2002) (228)
- Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins (2008) (219)
- Phylogenetic analysis of ribonuclease H domains suggests a late, chimeric origin of LTR retrotransposable elements and retroviruses. (2001) (218)
- Modular Evolution of the Integrase Domain in the Ty3/Gypsy Class of LTR Retrotransposons (1999) (207)
- Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. (2003) (198)
- Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H (2006) (197)
- Antiretroelement activity of APOBEC3H was lost twice in recent human evolution. (2008) (196)
- Conflict begets complexity: the evolution of centromeres. (2002) (192)
- Extensive evolutionary and functional diversity among mammalian AIM2-like receptors (2012) (188)
- The evolutionary conundrum of pathogen mimicry (2009) (185)
- Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals (2007) (181)
- Positive Selection and Increased Antiviral Activity Associated with the PARP-Containing Isoform of Human Zinc-Finger Antiviral Protein (2008) (169)
- Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. (2014) (169)
- Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects (2014) (162)
- Identification of the endonuclease domain encoded by R2 and other site-specific, non-long terminal repeat retrotransposable elements. (1999) (157)
- Altered Heterochromatin Binding by a Hybrid Sterility Protein in Drosophila Sibling Species (2009) (155)
- Paleovirology—Modern Consequences of Ancient Viruses (2010) (146)
- Ancient Adaptive Evolution of Tetherin Shaped the Functions of Vpu and Nef in Human Immunodeficiency Virus and Primate Lentiviruses (2010) (143)
- Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes (2013) (142)
- The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions. (2009) (137)
- Evolutionary specialization of the nuclear targeting apparatus. (1997) (134)
- Multiple roles for heterochromatin protein 1 genes in Drosophila. (2009) (134)
- Positive Selection Drives the Evolution of rhino, a Member of the Heterochromatin Protein 1 Family in Drosophila (2005) (133)
- Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts (2014) (132)
- Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. (2012) (128)
- Restriction of an Extinct Retrovirus by the Human TRIM5α Antiviral Protein (2007) (128)
- Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone (2002) (119)
- The RTE class of non-LTR retrotransposons is widely distributed in animals and is the origin of many SINEs. (1998) (118)
- Centromeres: Selfish drivers (2002) (117)
- High-Frequency Persistence of an Impaired Allele of the Retroviral Defense Gene TRIM5α in Humans (2006) (115)
- Genetic conflicts: the usual suspects and beyond (2017) (110)
- Paleovirology - ghosts and gifts of viruses past. (2011) (108)
- The domain structure and retrotransposition mechanism of R2 elements are conserved throughout arthropods. (1999) (103)
- Evolutionary cell biology: Two origins, one objective (2014) (101)
- Stepwise Evolution of Essential Centromere Function in a Drosophila Neogene (2013) (98)
- Are retrotransposons long-term hitchhikers? (1998) (94)
- Convergent Evolution of Escape from Hepaciviral Antagonism in Primates (2012) (93)
- Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast (2014) (90)
- Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein. (2007) (85)
- The centromere-drive hypothesis: a simple basis for centromere complexity. (2009) (81)
- Transferred interbacterial antagonism genes augment eukaryotic innate immune function (2014) (81)
- Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus? (2016) (79)
- NeSL-1, an ancient lineage of site-specific non-LTR retrotransposons from Caenorhabditis elegans. (2000) (75)
- Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals (2016) (74)
- Host gene evolution traces the evolutionary history of ancient primate lentiviruses (2013) (71)
- wtf genes are prolific dual poison-antidote meiotic drivers (2017) (70)
- Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans. (2000) (69)
- An expanded clade of rodent Trim5 genes. (2009) (67)
- Ancient lineages of non-LTR retrotransposons in the primitive eukaryote, Giardia lamblia. (2002) (67)
- An evolutionary perspective on the broad antiviral specificity of MxA. (2013) (66)
- A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster (2016) (65)
- Positive Selection of Iris, a Retroviral Envelope–Derived Host Gene in Drosophila melanogaster (2005) (63)
- Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline. (2016) (62)
- The Breadth of Antiviral Activity of Apobec3DE in Chimpanzees Has Been Driven by Positive Selection (2011) (62)
- The CNA1 histone of the ciliate Tetrahymena thermophila is essential for chromosome segregation in the germline micronucleus. (2005) (59)
- Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis (2006) (57)
- The cellular mechanisms and consequences of centromere drive. (2018) (55)
- An essential cell cycle regulation gene causes hybrid inviability in Drosophila (2015) (55)
- Genetic conflicts during meiosis and the evolutionary origins of centromere complexity. (2006) (54)
- A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli. (1998) (53)
- Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila (2007) (51)
- Dual recognition-incision enzymes might be involved in mismatch repair and meiosis. (2000) (50)
- Phylogenomic Analysis Reveals Dynamic Evolutionary History of the Drosophila Heterochromatin Protein 1 (HP1) Gene Family (2012) (44)
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing (2020) (43)
- Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction (2015) (43)
- Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome (2019) (42)
- The piggyBac transposon-derived genes TPB1 and TPB6 mediate essential transposon-like excision during the developmental rearrangement of key genes in Tetrahymena thermophila (2016) (38)
- Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes (2013) (37)
- Recurrent Gene Duplication Leads to Diverse Repertoires of Centromeric Histones in Drosophila Species (2016) (36)
- An Evolutionary Screen Highlights Canonical and Noncanonical Candidate Antiviral Genes within the Primate TRIM Gene Family (2013) (36)
- Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals (2017) (35)
- Evolution of a transcriptional regulator from a transmembrane nucleoporin (2016) (34)
- Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases (2020) (34)
- Ribonuclease H evolution in retrotransposable elements (2005) (33)
- Centromeres (2016) (31)
- Mimulus finds centromeres in the driver's seat. (2005) (29)
- Retrotransposable elements R1 and R2 in the rDNA units of Drosophila mercatorum: abnormal abdomen revisited. (1999) (28)
- Determining the evolutionary potential of a gene. (1998) (28)
- The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses (2012) (28)
- Retroviruses push the envelope for mammalian placentation (2012) (27)
- Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates (2020) (27)
- Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces (2010) (23)
- Positive Selection and Multiple Losses of the LINE-1-Derived L1TD1 Gene in Mammals Suggest a Dual Role in Genome Defense and Pluripotency (2014) (21)
- Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution. (2016) (21)
- The gene drive bubble: New realities (2017) (20)
- Absence of Positive Selection on Centromeric Histones in Tetrahymena Suggests Unsuppressed Centromere-Drive in Lineages Lacking Male Meiosis (2011) (19)
- Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila (2020) (18)
- Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila (2017) (18)
- Birth, death, and replacement of karyopherins in Drosophila. (2012) (17)
- Short H2A histone variants are expressed in cancer (2021) (16)
- Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila. (2016) (16)
- A functional map of HIV-host interactions in primary human T cells (2022) (14)
- Chromosome Segregation: Human Female Meiosis Breaks All the Rules (2015) (13)
- EvoChromo: towards a synthesis of chromatin biology and evolution (2019) (13)
- Genetic Conflicts: Stronger Centromeres Win Tug-of-War in Female Meiosis (2014) (13)
- Mitotic fidelity requires transgenerational action of a testis-restricted HP1 (2015) (13)
- Evolutionary Landscapes of Host-Virus Arms Races. (2022) (13)
- Dynamic Evolution of De Novo DNA Methyltransferases in Rodent and Primate Genomes (2019) (11)
- Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races (2020) (11)
- Microbial Genomics: The Expanding Universe of Bacterial Defense Systems (2018) (11)
- Mobile genetic elements and genome evolution 2014 (2014) (11)
- Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline (2021) (10)
- Did a Single Amino Acid Change Make Ebola Virus More Virulent? (2016) (10)
- Hybridization promotes asexual reproduction in Caenorhabditis nematodes (2019) (9)
- A surrogate approach to study the evolution of noncoding DNA elements that organize eukaryotic genomes. (2009) (9)
- Ancient Coretention of Paralogs of Cid Centromeric Histones and Cal1 Chaperones in Mosquito Species (2020) (9)
- Ten-Kilodalton Domain in Ty3 Gag3-Pol3p between PR and RT Is Dispensable for Ty3 Transposition (2001) (8)
- Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins (2019) (8)
- Gametic specialization of centromeric histone paralogs in Drosophila virilis (2019) (8)
- Rapid evolution of centromeres and centromeric/kinetochore proteins (2012) (8)
- How a virus blocks a cellular emergency access lane to the nucleus, STAT! (2014) (7)
- Learning to Protect Your Genome on the Fly (2011) (7)
- Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA (2019) (7)
- Biparental contributions of the H2A.B histone variant control embryonic development in mice. (2020) (7)
- The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity (2021) (7)
- A hitchhiker's guide to survival finally makes CENs (2006) (6)
- Author response: Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects (2014) (5)
- Kindr Motors Drive in Meiosis (2018) (5)
- Diamonds and rust: how transposable elements influence mammalian genomes (2009) (5)
- A rapidly evolving genomic toolkit for Drosophila heterochromatin (2013) (5)
- A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function (2019) (5)
- Speciation via Autoimmunity: A Dangerous Mix (2014) (4)
- Combinatorial mutagenesis of rapidly-evolving residues yields super-restrictor antiviral proteins (2019) (4)
- The Evolution of Centromeric DNA Sequences (2008) (4)
- Culture shock (2017) (3)
- A rapidly evolving actin mediates fertility and developmental tradeoffs in Drosophila (2020) (3)
- Genetic conflicts between sex chromosomes drive expansion and loss of sperm nuclear basic protein genes in Drosophila (2022) (3)
- Molecular Evolution of Drosophila cdc6, an Essential DNA Replication-Licensing Gene, Suggests an Adaptive Choice of Replication Origins (2007) (3)
- Cryptic asexual reproduction in Caenorhabditis nematodes revealed by interspecies hybridization (2019) (2)
- A burst of genetic innovation in actin-related proteins (Arps) for testis-specific function in a Drosophila lineage (2019) (2)
- Waddington Redux: De Novo Mutations Underlie the Genetic Assimilation of Stress-Induced Phenocopies in Drosophila melanogaster (2017) (2)
- pathogen interactions − hostimmunity genes rapidly evolved in primates at discrete sites of The apolipoprotein L family of programmed cell death and Material Supplemental (2009) (2)
- Genetics: Master Regulator or Master of Disguise? (2017) (2)
- A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae (2020) (2)
- An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development (2021) (2)
- A Diversified Portfolio. (2016) (2)
- Author response: A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster (2016) (1)
- R2d2 and Hyperdrive Mechanisms (in Mouse Meiosis) (2015) (1)
- Evolutionary specialization of the nuclear targeting apparatus (nuclear transportya and b karyopherinsyArmadillo and HEAT motifs) (1997) (1)
- Evolution of TRIM antiviral genes in primate genomes (2009) (1)
- Characterizing the Function of Anti‐CRISPR protein AcrIIA11 (2020) (1)
- pathogen interactions - host immunity genes rapidly evolved in primates at discrete sites of The apolipoprotein L family of programmed cell death and (2010) (1)
- AcrIIA22 is a novel anti-CRISPR that impairs SpyCas9 activity by relieving DNA torsion of target plasmids (2020) (1)
- L. pneumophila deploys a self-active inhibitor for inter-Legionella competition (2018) (1)
- Genes get diabolical (2007) (1)
- ID: 253: Evolution of antiviral factors in primates (2015) (1)
- The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses (2012) (1)
- Adaptive Evolution of Centromeric Proteins (2011) (1)
- Evolution-guided design of super-restrictor antiviral proteins reveals a breadth-versus-specificity tradeoff (2019) (1)
- Author response: wtf genes are prolific dual poison-antidote meiotic drivers (2017) (1)
- LINE-1 Retroelements Get ZAPped! (2015) (1)
- Meiosis: How Gambling Chromosomes Beat the Rules (2019) (1)
- Mobile DNA: an evolving field (2014) (1)
- Density-dependent resistance protectsLegionella pneumophilafrom its own antimicrobial metabolite, HGA (2018) (1)
- A unified phylogeny-based nomenclature for histone variants (2012) (1)
- The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months (2019) (1)
- Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes (2023) (1)
- Mobile genetic elements and genome evolution 2014 (2014) (1)
- Jody Rosenblatt (2016) (0)
- A hitchhiker’s guide to survival fi nally makes CENs (2006) (0)
- A balancing act between primate lentiviruses and their receptor (2021) (0)
- Mobile DNA: an evolving field (2014) (0)
- Driving lessons: a brief (personal) history of centromere drive (2022) (0)
- Author response: Mitotic fidelity requires transgenerational action of a testis-restricted HP1 (2015) (0)
- Putting the brakes on centromere drive in Mimulus (2021) (0)
- Natural variation in an essential host gene contributes to parasitic plasmid resistance in Saccharomyces cerevisiae (2020) (0)
- PLOS Pathogens 2017 Reviewer and Editorial Board Thank You (2018) (0)
- Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2017) (0)
- Author response: Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast (2014) (0)
- GUEST COMMENTARY Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins (2009) (0)
- Recurrent but Short-Lived Duplications of Centromeric Proteins in Holocentric Caenorhabditis Species (2022) (0)
- Author response: An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development (2021) (0)
- Disease consequences of conflict between mitochondrial and nuclear genomes (2015) (0)
- Passelègue Experiments on Crustal Rocks From Sub-Rayleigh to Supershear Ruptures During Stick-Slip (2013) (0)
- Harmit Malik (2020) (0)
- Author response: Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA (2019) (0)
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