Harren Jhoti
#76,379
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Structural biologist, co-founder and Chief Executive Officer Astex Therapeutics
Harren Jhoti's AcademicInfluence.com Rankings
Harren Jhotibiology Degrees
Biology
#4742
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#7037
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Molecular Biology
#2697
World Rank
#2738
Historical Rank
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Biology
Why Is Harren Jhoti Influential?
(Suggest an Edit or Addition)According to Wikipedia, Harren Jhoti is an Indian-born British structural biologist whose main interest has been rational drug design and discovery. He is president and chief executive officer of biotechnology company Astex Pharmaceuticals which is located in Cambridge, United Kingdom.
Harren Jhoti's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A 'rule of three' for fragment-based lead discovery? (2003) (1085)
- Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone (2004) (755)
- Crystal structure of human cytochrome P450 2C9 with bound warfarin (2003) (746)
- Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B (2003) (598)
- Twenty years on: the impact of fragments on drug discovery (2016) (578)
- High-throughput crystallography for lead discovery in drug design (2002) (477)
- Fragment-based lead discovery using X-ray crystallography. (2005) (373)
- Molecular structure of serum transferrin at 3.3-A resolution. (1988) (316)
- The 'rule of three' for fragment-based drug discovery: where are we now? (2013) (194)
- Crystal structure of human CDK4 in complex with a D-type cyclin (2009) (180)
- Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. (2005) (169)
- Fragment-based screening using X-ray crystallography and NMR spectroscopy. (2007) (148)
- Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. (2006) (131)
- The epidermolytic toxins are serine proteases (1990) (108)
- The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms (1995) (102)
- Structure-based screening of low-affinity compounds. (2002) (102)
- Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function (2012) (96)
- Detection of secondary binding sites in proteins using fragment screening (2015) (79)
- Automated Protein–Ligand Crystallography for Structure‐Based Drug Design (2006) (77)
- A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. (2007) (76)
- Detection of ligands from a dynamic combinatorial library by X-ray crystallography. (2003) (76)
- High-throughput crystallography to enhance drug discovery. (2003) (68)
- Structure-based Drug Discovery (2007) (66)
- High-throughput protein crystallography and drug discovery. (2004) (65)
- Prothoracicotropic hormone has an insulin‐like tertiary structure (1987) (63)
- High‐resolution X‐ray studies on rabbit serum transferrin: preliminary structure analysis of the N‐terminal half‐molecule at 2.3 Å resolution (1990) (55)
- The Discovery of Novel Protein Kinase Inhibitors by Using Fragment‐Based High‐Throughput X‐ray Crystallography (2005) (45)
- Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. (2019) (43)
- X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. (1994) (40)
- Fragment-based drug discovery using cryo-EM. (2019) (38)
- Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies. (1998) (37)
- Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket (2014) (33)
- High-throughput structural proteomics using x-rays. (2001) (30)
- Oxidation state of protein tyrosine phosphatase 1B (2003) (28)
- A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies. (1993) (25)
- The mechanism of iron uptake by transferrins: the structure of an 18 kDa NII-domain fragment from duck ovotransferrin at 2.3 A resolution. (1993) (24)
- Fragment-based drug discovery using rational design. (2007) (20)
- Thrombin inhibitors based on [5,5] trans-fused indane lactams. (1999) (20)
- A molecular model for the tumour‐associated antigen, p97, suggests a Zn‐binding function (1992) (19)
- A new school for screening (2005) (19)
- Fragments: where are we now? (2020) (17)
- Pyramid: An Integrated Platform for Fragment‐based Drug Discovery (2006) (15)
- High-throughput screening and structure-based approaches to hit discovery: is there a clear winner? (2013) (13)
- High throughput protein crystallography: Developments in crystallisation, data collection and data processing (2006) (8)
- Structure of human cytochrome P450 CYP2C9 (2003) (7)
- Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template. (1999) (7)
- X-ray Crystal Structure of Human Dopamine Sulfotransferase , SULT 1 A 3 (1999) (6)
- Protein–Protein Interactions: Putting the pieces together (1995) (6)
- Crystallization and preliminary analysis of an 18,000 Mr fragment of duck ovotransferrin. (1988) (6)
- High-throughput structural genomics and proteomics: where are we now? (2003) (5)
- Fragment based lead discovery using crystallography (2005) (3)
- High‐Throughput Crystallography (2008) (3)
- Cover Picture: Automated Protein–Ligand Crystallography for Structure-Based Drug Design (ChemMedChem 8/2006) (2006) (3)
- Crystallization and preliminary X-ray diffraction studies on ADP-ribosylation factor 1. (1994) (3)
- Selecting the Right Targets for Fragment‐Based Drug Discovery (2016) (3)
- Structural Biology and Anticancer Drug Design (2014) (2)
- Fragment Based Drug Discovery using rational design (2007) (2)
- Structural genomics: lessons to be learnt. (2001) (2)
- Structural studies on serum transferrin: the central protein of iron metabolism (1987) (1)
- Structural studies on transferrins: the anion-binding sites (1988) (1)
- CHAPTER 4 – Structural biology and anticancer drug design (2008) (1)
- High-throughput X-ray techniques and drug discovery. (2003) (1)
- High-Throughput Protein Crystallography and Drug Discovery (2005) (1)
- ERK2 mini-fragment binding (2019) (0)
- Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 3,5-dimethyl-1H-pyrazole-4-carboxylic acid (AT9084) in an alternate binding site. (2015) (0)
- Structure of PKA-PKB chimera complexed with A-443654 (2007) (0)
- PKM2 in complex with L-threonine (2020) (0)
- Beta-galactosidase in complex with deoxygalacto-nojirimycin (2020) (0)
- Common themes and surprising differences in small G-proteins. (1997) (0)
- Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site. (2015) (0)
- NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS (2000) (0)
- Protein tyrosine phosphatase 1B with active site inhibitor (2005) (0)
- High- Throughput Crystallography for Structural Proteomics (2005) (0)
- STRUCTURE OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH THE ELASTASE INHIBITOR GR143783 (1999) (0)
- Beta-galactosidase in complex with PETG (2020) (0)
- NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT (1998) (0)
- fragment based p38 inhibitors (2005) (0)
- Structure of cyclin-dependent kinase 2 with small-molecule ligand 4- fluorobenzoic acid (AT222) in an alternate binding site. (2015) (0)
- p38 Kinase crystal structure in complex with small molecule inhibitor (2005) (0)
- Structure of cAMP-dependent protein kinase complexed with A-443654 (2007) (0)
- Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site. (2015) (0)
- Structure of cyclin-dependent kinase 2 with small-molecule ligand 3-(4,7-dichloro-1H-indol-3-yl)prop-2-yn-1-ol (AT17833) in an alternate binding site. (2015) (0)
- Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE (2007) (0)
- Structure of Bacterial DNA Ligase with small-molecule ligand pyrimidin-2-amine (AT371) in an alternate binding site. (2015) (0)
- Discovery of AT26893, a novel allosteric inhibitor of the regulation of HCV NS3/4a protein function (2012) (0)
- Crystal structure of human cytochrome P450 3A4 (2004) (0)
- Structure of Bacterial DNA Ligase with small-molecule ligand 1H- indazol-7-amine (AT4213) in an alternate binding site. (2015) (0)
- Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 5-bromo-1-methyl-1H-indole-2-carboxylic acid (AT21457) in an alternate binding site. (2015) (0)
- CB&DD Editorial Advisory Board (fourth in series) (2006) (0)
- NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, MONOMERIC CRYSTAL FORM (1996) (0)
- Design, Development and Optimization: Crystal Structures of Microsomal Cytochromes P450 (2008) (0)
- Discovery of novel allosteric inhibitors of HCV NS3/4a enzyme via structure-based drug design (2012) (0)
- Active site thrombin inhibitors (2005) (0)
- Beta-galactosidase in complex with L-ribose (2020) (0)
- STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654 (2007) (0)
- Crystal structures of human cytochrome P450 2C9 and 3A4 with bound ligands (2004) (0)
- PKM2 in complex with Compound 5 (2020) (0)
- Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 2-(1-methyl-1H-indol-3-yl)acetic acid (AT3437) in an alternate binding site. (2015) (0)
- Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 3-aminobenzene-1,2-dicarboxylic acid (AT1246) in an alternate binding site. (2015) (0)
- Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site. (2015) (0)
- Structural biology of cytochromes P450 (2005) (0)
- Screening for fragment binding by X-ray crystallography (2005) (0)
- PKM2 in complex with Compound 10 (2020) (0)
- Identification of novel allosteric inhibitors through Fragment-Based Drug Discovery and X-ray crystallography (2015) (0)
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