Harry

Harry Klinefelter

#38,164
Most Influential Person Across History

Endocrinologist

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According to Wikipedia, Harry Fitch Klinefelter Jr. was an American rheumatologist and endocrinologist. Klinefelter syndrome is named after him. Biography Klinefelter studied first at the University of Virginia, Charlottesville, and then attained his medical degree from Johns Hopkins School of Medicine. After his graduation in 1937 he continued his training in internal medicine at the Johns Hopkins Hospital. Klinefelter worked at the Massachusetts General Hospital in Boston from 1941 to 1942; under the supervision of Fuller Albright he described a group of nine men with "gynecomastia, aspermatogenesis without aleydigism, and increased excretion of follicle-stimulating hormone", the first description of what would be called the Klinefelter syndrome. Initially he suspected this to be endocrine disorder and postulated the presence of a second testicular hormone, but in 1959, Patricia A. Jacobs and Dr. J. A. Strong demonstrated that a male patient with the phenotype of Klinefelter syndrome had an additional X chromosome . Klinefelter confirmed, later, that the cause was chromosomal, rather than hormonal.

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