Hartmuth C. Kolb

Q: What Schools Are Affiliated With Hartmuth C. Kolb

Hartmuth C. Kolb is affiliated with the following schools: University of Marburg, California Institute of Technology, University of California, San Diego, University of California, Los Angeles

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Hartmuth C. Kolb

Chemistry

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Chemistry

Hartmuth C. Kolb's Degrees

PhD Chemistry University of Marburg

Why Is Hartmuth C. Kolb Influential?

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According to Wikipedia, Hartmuth Christian Kolb is a German chemist. He is considered one of the founders of click chemistry. Early life and career After graduating from high school in Marsberg in 1983, Kolb studied at the University of Hanover. He received his doctorate as an academic student of Steven Ley at Imperial College London with a thesis on preparative organic chemistry . As a postdoctoral fellow he worked with Barry Sharpless at the Scripps Research Institute in La Jolla, California. He then worked in the research department of Ciba-Geigy in Basel from 1993 to 1997 before taking up a managerial position at Coelacanth Corporation, founded by Sharpless and A. Bader in Princeton, New Jersey. Coelacanth was eventually acquired by Lexicon Pharmaceuticals.

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Hartmuth C. Kolb's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Click Chemistry: Diverse Chemical Function from a Few Good Reactions. (2001) (9531)
Catalytic Asymmetric Dihydroxylation (1994) (2645)
The growing impact of click chemistry on drug discovery. (2003) (2514)
"On water": unique reactivity of organic compounds in aqueous suspension. (2005) (1288)
Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen (2001) (1224)
Drug discovery today. (2003) (1202)
Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808. (2014) (525)
Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. (2013) (522)
[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease (2013) (468)
Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics (2005) (458)
Inhibitors of HIV-1 protease by using in situ click chemistry. (2006) (447)
In situ click chemistry: enzyme inhibitors made to their own specifications. (2004) (342)
The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities. (2014) (277)
In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. (2005) (273)
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation. (2004) (270)
A simplified procedure for the stereospecific transformation of 1,2-diols into epoxides (1992) (221)
In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II. (2004) (195)
Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease (2020) (195)
A highly selective and specific PET tracer for imaging of tau pathologies. (2012) (158)
Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. Kinetics (1994) (155)
Integrated microfluidics for parallel screening of an in situ click chemistry library. (2006) (150)
Improved enantioselectivity in asymmetric dihydroxylations of terminal olefins using pyrimidine ligands (1993) (145)
Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer Using 89Zr-Trastuzumab PET/CT (2016) (136)
Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging (2011) (131)
PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects (2018) (122)
PET imaging of hypoxia using [18F]HX4: a phase I trial (2010) (114)
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice (2019) (109)
Inflammatory biomarkers in Alzheimer's disease plasma (2019) (104)
An integrated microfluidic device for large-scale in situ click chemistry screening. (2009) (99)
Large-scale and highly enantioselective synthesis of the taxol C-13 side chain through asymmetric dihydroxylation (1994) (98)
Biodistribution and Radiation Dosimetry of the Integrin Marker 18F-RGD-K5 Determined from Whole-Body PET/CT in Monkeys and Humans (2012) (92)
The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable (2018) (90)
Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future. (2015) (85)
Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis (2010) (80)
Total synthesis of the anthelmintic macrolide avermectin B1a (1991) (80)
18F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with 18F-FMISO (2012) (79)
BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders (2015) (79)
Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons (2009) (79)
Toward an understanding of the high enantioselectivity in the osmium-catalyzed asymmetric dihydroxylation. 4. Electronic effects in amine-accelerated osmylations (1997) (73)
DEVELOPMENT OF TOOLS FOR THE DESIGN OF SELECTIN ANTAGONISTS (1997) (71)
Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation. 2. A Qualitative Molecular Mechanics Approach (1994) (68)
Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer. (2013) (64)
Sialyl Lewis(x) (sLe(x)) and an sLe(x) mimetic, CGP69669A, disrupt E-selectin-dependent leukocyte rolling in vivo. (1998) (61)
Short and practical syntheses of(R)-(−)-carnitine and (R)-(−)-γ-amino-β-hydroxybutyric acid (GABOB) (1993) (57)
A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. (2012) (53)
18F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446 (2018) (52)
Repeatability of hypoxia PET imaging using [18F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial (2015) (49)
Biodistribution and radiation dosimetry of the hypoxia marker 18F–HX4 in monkeys and humans determined by using whole-body PET/CT (2010) (48)
A total synthesis of racemic and optically active terrein (trans-4,5-dihydroxy-3-[(E)-1-propenyl]-2-cyclopenten-1-one). (1990) (48)
Batch‐mode microfluidic radiosynthesis of N‐succinimidyl‐4‐[18F]fluorobenzoate for protein labelling (2011) (43)
Calculations on the reaction of ruthenium tetroxide with olefins using density functional theory (DFT). Implications for the possibility of intermediates in osmium-catalyzed asymmetric dihydroxylation (1994) (42)
The synthesis of azadirachtin: a potent insect antifeedant. (2008) (41)
Evaluation of [18F]-CP18 as a PET Imaging Tracer for Apoptosis (2013) (40)
PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation (2019) (38)
Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease: A Truncated Randomized Phase 2b/3 Clinical Trial. (2021) (38)
Atherosclerotic plaque uptake of a novel integrin tracer 18F-Flotegatide in a mouse model of atherosclerosis (2014) (37)
Efficient one-Pot synthesis of polysubstituted pyrroles. (2000) (37)
On "The origin of high enantioselectivity in the dihydroxylation of olefins using osmium tetraoxide and cinchona alkaloid catalysts" (1993) (36)
Applications of click chemistry in radiopharmaceutical development. (2010) (36)
Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE. (2005) (33)
Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET. (2010) (33)
Noninvasive Molecular Imaging of Apoptosis in a Mouse Model of Anthracycline-Induced Cardiotoxicity (2015) (33)
Preclinical Evaluation and Nonhuman Primate Receptor Occupancy Study of 18F-JNJ-64413739, a PET Radioligand for P2X7 Receptors (2019) (32)
Biodistribution and Radiation Dosimetry of 18F-CP-18, a Potential Apoptosis Imaging Agent, as Determined from PET/CT Scans in Healthy Volunteers (2013) (32)
Chemistry of insect antifeedants from Azadirachta indica(part 12): use of silicon as a control element in the synthesis of a highly functionalized decalin fragment of azadirachtin (1992) (32)
Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation. (2013) (29)
Chemistry of insect antifeedants from Azadirachta indica (Part 10): synthesis of a highly functionalised decalin fragment of azadirachtin. (1991) (27)
Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans (2020) (25)
In Vitro and In Vivo Evaluation of the Caspase-3 Substrate-Based Radiotracer [18F]-CP18 for PET Imaging of Apoptosis in Tumors (2013) (24)
Recent progresses in the glycodrug area (1997) (24)
Biodistribution and Radiation Dosimetry of the Carbonic Anhydrase IX Imaging Agent [18 F]VM4-037 Determined from PET/CT Scans in Healthy Volunteers (2014) (24)
Tau Positron Emission Tomography Imaging. (2017) (24)
Comparing two models for the selectivity in the asymmetric dihydroxylation reaction (AD) (1994) (23)
Synthesis of [18F]RGD-K5 by catalyzed [3 + 2] cycloaddition for imaging integrin αvβ3 expression in vivo. (2013) (21)
Cover Picture: “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension (Angew. Chem. Int. Ed. 21/2005) (2005) (20)
First in human evaluation of a newly developed integrin binding PET tracer, 18F-RGD-K5 in patients with breast cancer: Comparison with 18F-FDG uptake pattern and microvessel density (2009) (20)
Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease (2022) (19)
Total Synthesis of Avermectin B1a: Synthesis of the C11-C25 Spiroacetal Fragment (1990) (19)
Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a (1990) (19)
Comparison of the Bioactive Conformations of Sialyl LewisX and a Potent Sialyl LewisX Mimic (1997) (19)
A ring contraction of 6-alkoxy-2,3-dihydro-6H-pyran-3-ones to polyfunctionalized cyclopentenones (1990) (18)
Molecular basis of interactions of cholinesterases with tight binding inhibitors. (2005) (18)
Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer. (2019) (18)
Novel syntheses of polysubstituted pyrroles and oxazoles by 1,3-dipolar cycloaddition reactions of benzotriazole-stabilized nitrile ylides (2002) (18)
Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([18F]-FMISO). (2012) (18)
Design and synthesis of sialyl Lex mimetics based on carbocyclic scaffolds derived from (−) quinic acid (1997) (14)
Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer’s disease (2020) (14)
Development and validation of a high‐sensitivity assay for measuring p217+tau in plasma (2021) (14)
Synthesis of novel cyclobutylphosphonic acids as inhibitors of imidazole glycerol phosphate dehydratase (1997) (13)
A SINGLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF THE ANTI-PHOSPHO-TAU ANTIBODY JNJ-63733657 IN HEALTHY SUBJECTS (2019) (13)
Flow optimization study of a batch microfluidics PET tracer synthesizing device (2010) (12)
Effects of Mu-Opiate Receptor Gene Polymorphism rs1799971 (A118G) on the Antidepressant and Dissociation Responses in Esketamine Nasal Spray Clinical Trials (2020) (12)
S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies. (2018) (11)
Titelbild: “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension (Angew. Chem. 21/2005) (2005) (10)
Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid (2020) (10)
Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography (2022) (10)
From In Situ to In Vivo: An In Situ Click‐Chemistry‐Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography (2013) (10)
Exploratory analyses of regional human brain distribution of the PET tau tracer F18-labeled T807 (AV-1541) in subjects with normal cognitive function or cognitive impairment thought to be due to Alzheimer's disease (2013) (10)
Design and synthesis of a macrocyclic E-selectin antagonist (1997) (9)
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays. (2022) (9)
18F-RGD-K5: A cyclic triazole-bearing RGD peptide for imaging integrin αvβ3 expression in vivo (2009) (9)
Click Chemistry for Drug Discovery (2006) (9)
Replication study of plasma proteins relating to Alzheimer's pathology (2021) (8)
Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability. (2016) (8)
Comparative analytical performance of multiple plasma Aβ42 and Aβ40 assays and their ability to predict positron emission tomography amyloid positivity (2022) (8)
A Total Synthesis of Racemic and Optically Active Terrein (trans-4,5-Dihydroxy-3-((E)-1-propenyl)-2-cyclopenten-1-one). (1990) (8)
Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin. (1998) (7)
Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum (2022) (7)
Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus (2021) (7)
First case report: Image to autopsy correlation for tau imaging with [18F]-T808 (AV-680) (2013) (7)
Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE, Chem Biol Interact. 157-158, 159-65. (2004) (7)
Click chemistry connections for functional discovery (2022) (6)
Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans. (2021) (6)
Efficient solution phase parallel synthesis of norstatine analogs (2004) (6)
Radiosynthesis of 3′‐Deoxy‐3′‐[18F]Fluorothymidine ([18F]FLT) (2012) (6)
Synthesis of an 18F-labeled RGD peptide for imaging αvβ3 integrin expression in vivo (2009) (5)
394. Development and Preclinical Evaluation of [18F]JNJ-64413739 as a PET Radioligand for P2X7 Receptors (2017) (5)
Chemistry of insect antifeedants from Azadirachta indica(part 13): on the use of the intramolecular Diels–Alder reaction for the construction of trans-fused hydrobenzofuran fragments for azadirachtin synthesis (1992) (5)
Vergleich der bioaktiven Konformationen von Sialyl‐LewisX und einem potenten Sialyl‐LewisX‐Mimetikum (1997) (5)
A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index (2021) (4)
Diagnostic and prognostic performance to detect Alzheimer’s disease and clinical progression of a novel assay for plasma p-tau217 (2022) (4)
Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid (2018) (4)
Improved Enantioselectivity in Asymmetric Dihydroxylations of Terminal Olefins Using Pyrimidine Ligands. (1993) (3)
Short and Practical Syntheses of (R)‐(‐)‐Carnitine and (R)‐(‐)‐γ‐ Amino‐β‐hydroxybutyric Acid (GABOB). (1993) (3)
Automated Microfluidic-Chip-Based Stand-Alone Instrument for the Synthesis of Radiopharmaceuticals on Human-Dose Scales (2007) (3)
PRE-CLINICAL CHARACTERIZATION OF THE NOVEL TAU PET LIGAND [18F]-JNJ'067 (2017) (2)
18F-RGD-K5: A cyclic triazole-bearing RGD peptide for imaging integrin {alpha}v{beta}3 expression in vivo (2009) (2)
Carbohydrate Mimetics in Drug Discovery (2005) (2)
Automated Microfluidic Chip and System for the Synthesis of Radiopharmaceuticals on Human-Dose Scales (2007) (2)
Dictionary of Chemistry and Chemical Engineering (1978) (2)
Toward an Understanding of the High Enantioselectivity in the Osmium‐ Catalyzed Asymmetric Dihydroxylation (AD). Part 1. Kinetics. (1994) (1)
Exploration of β-Turn Scaffolding Motifs as Components of Sialyl Lex Mimetics and Their Relevance to P-Selectin. (1999) (1)
LONGITUDINAL COMPARISON OF CSF BIOMARKERS OF NEURODEGENERATION IN PATIENTS WITH PROBABLE IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS (INPH) (2019) (1)
Novel Syntheses of Polysubstituted Pyrroles and Oxazoles by 1,3‐Dipolar Cycloaddition Reactions of Benzotriazole‐Stabilized Nitrile Ylides. (2002) (1)
Discovery of novel [18F]-PET agents for imaging neurofibrillary tangles (NFTs) (2011) (1)
Novel, small molecule [F18]-PET tracers for imaging of tau in human AD brains (2011) (1)
18F-CP18: A novel DEVD containing peptide substrate for imaging apoptosis via Caspase-3 activity (2011) (1)
Chemistry of Insect Antifeedants from Azadirachta indica. Part 12. Use of Silicon as a Control Element in the Synthesis of a Highly Functionalized Decalin Fragment of Azadirachtin. (1993) (1)
Evaluation of 18F‐JNJ‐067 as a tau tracer (2020) (1)
IMAGING ALZHEIMER'S TAU PATHOLOGY IN HUMANS: [18F]JNJ-067—A PHASE 0 EXPLORATORY STUDY IN HEALTHY VOLUNTEERS AND SUBJECTS WITH PROBABLE ALZHEIMER'S DISEASE (2018) (1)
Plasma p217+tau vs NAV4694 amyloid and MK6240 tau PET across the Alzheimer continuum. (2022) (1)
Correction: Diagnostic and prognostic performance to detect Alzheimer’s disease and clinical progression of a novel assay for plasma p-tau217 (2022) (1)
Abstract 5583: Response biomarkers for the hypoxia-targeted drug TH-302: imaging, plasma, and tissue. (2013) (1)
FINAL EFFICACY, SAFETY AND BIOMARKER RESULTS OF THE PHASE 2B/3 RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED EARLY TRIAL OF ATABECESTAT IN PRECLINICAL ALZHEIMER’S DISEASE (2019) (1)
Synthesis of an 18F-labeled CP18 peptide as a potential apoptosis biomarker in PET imaging (2011) (1)
307. Potential Biomarkers of Impending Schizophrenia Relapse: Exploratory Analysis of a Randomized, Double-Blind, Placebo-Controlled, Phase-3 Study of Paliperidone Palmitate 3-Month Formulation (2017) (1)
Design and Synthesis of a Macrocyclic E‐Selectin Antagonist (I) (1998) (0)
Comparative analytical performance of multiple plasma amyloid‐beta assays and their relationship to amyloid PET (2021) (0)
Synthesis of an 18F-labeled click chemistry-derived 2-nitroimidazole containing tracer for imaging hypoxia in vivo (2009) (0)
Evaluation of 18 F‐JNJ‐067 as a tau tracer: Neuroimaging / New imaging methods (2020) (0)
296. Correlating Peripheral and Central Markers of Neuroinflammation to PET Imaging of Translocator Protein (TSPO) (2017) (0)
[A contribution on the demonstration of the presence of drugs in body fluids by gas chromatography]. (1965) (0)
RGD-K 5 by catalyzed [ 3 + 2 ] cycloaddition for imaging integrin alpha ( v ) beta ( 3 ) expression in vivo (2013) (0)
11C-labeled peptide for detection of a diseased tissue (2010) (0)
Click chemistry: an original approach for drug discovery (2004) (0)
Profiling classical neuropsychiatric biomarkers across biological fluids and following continuous lumbar puncture: A guide to sample type and time (2022) (0)
Novel approach to PET probe synthesis involving a microfluidic coin-shaped reactor (2006) (0)
66 poster: Imaging Hypoxia Response Using Fluorescent and Fluorine-18 Labeled Sulfonamide Inhibitors of CA IX (2010) (0)
Inside Cover: From In Situ to In Vivo: An In Situ Click‐Chemistry‐Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography (ChemMedChem 1/2013) (2013) (0)
Preparation of 18F-labeled thymidine analogs using click chemistry (2006) (0)
Synthesis of an 18F-labeled RGD peptide for imaging {alpha}v{beta}3 integrin expression in vivo (2009) (0)
microfluidic chip radioactively labeled molecules can be synthesized on a scale suitable for imaging in humans with positron emission tomography (2006) (0)
Synthesis and Reactivity of Compounds with Cyclobutane Ring(s). Part 20. Synthesis of Novel Cyclobutylphosphonic Acids as Inhibitors of Imidazole Glycerol Phosphate Dehydratase. (1997) (0)
In situ click chemistry approach for the identification of carbonic anhydrase II and cyclooxygenase-2 PET imaging agents (2006) (0)
Synthesis of [F-18]RGD-K5 by catalyzed [3+2] cycloaddition for imaging integrin alpha(v)beta(3) expression in vivo (2013) (0)
An improved reliable labeling protocol of [11C]GR205171 (2007) (0)
Revealing the combined roles of Aβ and tau in Alzheimer’s disease via a pathophysiological activity decoder (2023) (0)
Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) (0)
Cover Picture: The Synthesis of Azadirachtin: A Potent Insect Antifeedant (Chem. Eur. J. 34/2008) (2008) (0)
Total Synthesis of the Anthelmintic Macrolide Avermectin B1a. (1991) (0)
A head‐to‐head comparison of plasma phosphorylated tau assays in the real‐world memory clinic (2022) (0)
A VALUABLE TOOL FOR PEPTIDE AND PROTEIN MODIFICATION (2016) (0)
Dependent Leukocyte Rolling In Vivo - Sialyl Lewisx (sLex) and an sLexMimetic, CGP69669A, Disrupt E-Selectin (2013) (0)
Crystal structure of the mouse acetylcholinesterase-TZ2PA6 anti complex (2004) (0)
Correction to Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer. (2020) (0)
Erratum to “Efficient solution phase parallel synthesis of norstatine analogs” [Tetrahedron 60 (2004) 9043] (2004) (0)
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease. (2023) (0)
11c-labelled peptide for detecting a tumour which expresses a peptide transporter (2011) (0)
11C-labeled peptide for detection of a tumor that expresses a Her2 / neu receptor (2010) (0)
Catalytic Asymmetric Di hydroxylation (2001) (0)
Large‐Scale and Highly Enantioselective Synthesis of the Taxol C‐13 Side Chain (VII) Through Asymmetric Dihydroxylation. (1995) (0)
Chemistry of Insect Antifeedants from Azadirachta indica. Part 13. On the Use of the Intramolecular Diels‐Alder Reaction for the Construction of trans‐Fused Hydrobenzofuran Fragments for Azadirachtin Synthesis. (1993) (0)
Aptamer complex for detection of a diseased tissue (2010) (0)
Coin-Shaped Reactor in Microfluidic Devices Used for Radiopharmaceutical Synthesis (2006) (0)
FTS3-01-03 PERFORMANCE ON EXPLORATORY EFFICACY VARIABLES IN AMARANTH, A RANDOMIZED PHASE 2/3 STUDY IN EARLYALZHEIMER’S DISEASE WITH LANABECESTAT FINAL EFFICACY, SAFETYAND BIOMARKER RESULTS OF THE PHASE 2B/3 RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED EARLY TRIAL OF ATABECESTAT IN PRECLINICAL ALZH (2019) (0)
P301L TAU DEMONSTRATES ALTERED MODULATION OF CALMODULIN-DEPENDENT PDE1 AND CALCINEURIN IN VITRO (2016) (0)
Abstract 18681: Molecular Imaging of Angiogenesis in Atherosclerosis Using a Caspase 3 Targeted PET Tracer 18F-CP18 (2012) (0)
555. Gene Expression Differences Associated with Major Psychiatric Disorders in the Human Prefrontal Cortex and Hippocampus (2017) (0)
System, device and method for the preparation of tracers and transfer of materials during radiosynthesis (2012) (0)
Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease (2020) (0)
[18F]THK-5117-PET AND [11C]PIB-PET IMAGING IN IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS (INPH) IN RELATION TO CONFIRMED AMYLOID-β PLAQUES AND TAU IN BRAIN BIOPSIES (2017) (0)
11c-labelled peptide for detecting an antibody (2011) (0)
A Ring Contraction of 6-Alkoxy-2,3-dihydro-6H-pyran-3-ones to Polyfunctionalized Cyclopentenones. (1990) (0)
Plasma p217+tau concordance with 18F‐NAV4694 beta‐amyloid and 18F‐MK6240 tau PET in mild Alzheimer’s disease and cognitively unimpaired participants in the AIBL/ADNeT cohort (2021) (0)
Radiosynthesis of [18F]Flotegatide ([18F]RGD‐K5) (2015) (0)
Diagnostic and prognostic performance to detect Alzheimer’s disease and clinical progression of a novel assay for plasma p-tau217 (2022) (0)
Evaluation of [F-18]HX4 (a hypoxic tumor marker) to detect hypoxia in tumors: Correlation with FDG PET (2012) (0)
11 oral: Preclinical Evaluation Of [18f]Hx4, A Novel and Promising Hypoxia Marker for Pet Imaging (2010) (0)
A Simplified Procedure for the Stereospecific Transformation of 1,2- Diols into Epoxides. (1993) (0)
S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus (iNPH) in Relation to Confirmed Amyloi (2018) (0)
Reaction of α,β-dihydroxydihydrocinnamic esters with acetonitrile: a new approach to β-amino-α-hydroxydihydrocinnamic acids (2002) (0)
Efficient Solution Phase Parallel Synthesis of Norstatine Analogues. (2005) (0)
Correction: Diagnostic and prognostic performance to detect Alzheimer’s disease and clinical progression of a novel assay for plasma p-tau217 (2022) (0)

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