Haruhiko Akiyama
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Philosophy Biology
Haruhiko Akiyama's Degrees
- PhD Neuroscience University of Tokyo
- Doctorate Medicine University of Tokyo
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(Suggest an Edit or Addition)Haruhiko Akiyama's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Inflammation and Alzheimer’s disease (2000) (4327)
- TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (2006) (2228)
- Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease (1989) (901)
- Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update (2009) (869)
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders (2010) (739)
- Prion-like spreading of pathological α-synuclein in brain (2013) (641)
- Microglia in degenerative neurological disease (1993) (603)
- Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (2008) (590)
- Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. (1992) (566)
- Rate of cell death in parkinsonism indicates active neuropathological process (1988) (560)
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction (2009) (510)
- Immune System Response in Alzheimer's Disease (1989) (468)
- Brain microglia constitutively express β-2 integrins (1990) (402)
- Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations (2008) (398)
- Prion-like properties of pathological TDP-43 aggregates from diseased brains. (2013) (395)
- Activation of the classical complement pathway in brain tissue of Alzheimer patients (1989) (395)
- Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases (2002) (357)
- Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide (2001) (350)
- Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies (2009) (311)
- Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43 (2009) (269)
- INFLAMMATION AND ALZHEIMERS DISEASE (2000) (253)
- Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue (1988) (247)
- Cell mediators of inflammation in the Alzheimer disease brain. (2000) (242)
- TDP-43 is deposited in the Guam parkinsonism-dementia complex brains. (2007) (212)
- Pathological alpha-synuclein propagates through neural networks (2014) (202)
- Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy (2001) (187)
- Microglial response to 6-hydroxydopamine-induced substantia nigra lesions (1989) (179)
- Abnormal phosphorylation of Ser409/410 of TDP‐43 in FTLD‐U and ALS (2008) (179)
- Thrombin accumulation in brains of patients with Alzheimer's disease (1992) (176)
- Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease (1990) (170)
- Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions (1988) (164)
- The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis (2017) (164)
- Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders (2008) (162)
- Brain microglia constitutively express beta-2 integrins. (1990) (161)
- Identification of amino‐terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration (2004) (152)
- Identification of septins in neurofibrillary tangles in Alzheimer's disease. (1998) (148)
- Inflammatory response in Alzheimer's disease. (1994) (144)
- Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau (2015) (141)
- Distribution of choline acetyltransferase immunopositive structures in the rat brainstem (1989) (139)
- Vascular and parenchymal Aβ deposition in the aging dog: correlation with behavior (2000) (131)
- Expression of CD40 in the brain of Alzheimer’s disease and other neurological diseases (2000) (131)
- Fas antigen expression in brains of patients with Alzheimer-type dementia (1995) (131)
- Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis (1994) (130)
- Immunohistochemical demonstration of glutaminase in catecholaminergic and serotoninergic neurons of rat brain (1990) (128)
- Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue (1991) (127)
- Reticulons RTN3 and RTN4‐B/C interact with BACE1 and inhibit its ability to produce amyloid β‐protein (2006) (124)
- Phosphorylated and ubiquitinated TDP‐43 pathological inclusions in ALS and FTLD‐U are recapitulated in SH‐SY5Y cells (2009) (123)
- Early response of brain resident microglia to kainic acid-induced hippocampal lesions (1994) (118)
- Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease (1994) (114)
- Phosphorylated and cleaved TDP‐43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP‐43 proteinopathy (2010) (113)
- Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains (2013) (111)
- Methylene blue and dimebon inhibit aggregation of TDP‐43 in cellular models (2009) (109)
- Identification of casein kinase-1 phosphorylation sites on TDP-43. (2009) (108)
- SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions (2017) (106)
- Expression of MRP14, 27E10, interferon-α and leukocyte common antigen by reactive microglia in postmortem human brain tissue (1994) (106)
- Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain (1991) (104)
- Submandibular gland needle biopsy for the diagnosis of Parkinson disease (2014) (103)
- Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects (2014) (102)
- Glial Tau Pathology in Neurodegenerative Diseases: Their Nature and Comparison with Neuronal Tangles (1998) (101)
- Changes in density of calcium‐binding‐protein‐immunoreactive GABAergic neurons in prefrontal cortex in schizophrenia and bipolar disorder (2008) (98)
- Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy (2010) (97)
- Occurrence of the diffuse amyloid β‐protein (Aβ) deposits with numerous Aβ‐containing glial cells in the cerebral cortex of patients with Alzheimer's disease (1999) (97)
- Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy (1994) (97)
- Submandibular gland biopsy for the diagnosis of Parkinson disease. (2013) (95)
- Reactions of the Immune System in Chronic Degenerative Neurological Diseases (1991) (92)
- Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid β-protein (Aβ) deposition (2001) (92)
- Molecular analysis and biochemical classification of TDP-43 proteinopathy. (2012) (92)
- High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies (2020) (91)
- Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders (2004) (91)
- Immunohistochemical localization of beta‐amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy (1992) (90)
- Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease (2009) (89)
- Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62 (2003) (88)
- Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease (1993) (88)
- Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies (2008) (87)
- Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43* (2016) (86)
- Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles (2004) (86)
- Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/α-synuclein (1999) (83)
- 18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans (1990) (82)
- Herpes simplex virus type I infection of the CNS induces major histocompatibility complex antigen expression on rat microglia (1990) (80)
- Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration (2009) (80)
- Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies (2012) (80)
- Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review (1996) (78)
- Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory (1997) (77)
- The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system (2009) (77)
- Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling. (2001) (77)
- Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain. (1993) (76)
- The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation* (2016) (76)
- Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein (1996) (74)
- Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain. (1997) (72)
- Immunohistochemical localization of hyaluronic acid in rat and human brain (1994) (72)
- Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice (2012) (71)
- Distribution of phosphate‐activated glutaminase in the human cerebral cortex (1990) (70)
- Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions (2009) (69)
- Complement-activated oligodendroglia: A new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d (1990) (68)
- Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease (1998) (68)
- Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau (2015) (66)
- Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. (1999) (63)
- Basophilic inclusion body disease and neuronal intermediate filament inclusion disease: a comparative clinicopathological study (2008) (63)
- Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain (2003) (62)
- Biochemical Increase in Phosphorylated Alpha‐Synuclein Precedes Histopathology of Lewy‐Type Synucleinopathies (2012) (61)
- Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies (2001) (60)
- Clinical aspects of argyrophilic grain disease. (2000) (60)
- Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease (2010) (59)
- Association of amyloid P component with complement proteins in neurologically diseased brain tissue (1991) (56)
- Specificity of mechanisms for plaque removal after Aβ immunotherapy for Alzheimer disease (2004) (56)
- Subcellular localization of the low density lipoprotein receptor-related protein (α 2-macroglobulin receptor) in human brain (1995) (55)
- Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease. (1998) (54)
- A case of adult‐onset dementia with argyrophilic grains (1989) (53)
- Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease (1993) (53)
- Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using α-synuclein-immunohistochemistry (2000) (52)
- Molecular Dissection of TDP-43 Proteinopathies (2011) (51)
- Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles (2010) (51)
- Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain (2013) (51)
- High-contrast in-vivo imaging of tau pathologies in Alzheimer’s and non-Alzheimer’s disease tauopathies (2020) (50)
- Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration (2003) (49)
- Numerous glial fibrillary tangles in oligodendroglia in cases of subacute sclerosing panencephalitis with neurofibrillary tangles (1995) (49)
- Amino‐truncated amyloid β‐peptide (Aβ5‐40/42) produced from caspase‐cleaved amyloid precursor protein is deposited in Alzheimer’s disease brain (2004) (48)
- T-cell infiltration and expression of MHC class II antigen by macrophages and microglia in a heterogeneous group in leukoencephalopathy. (1993) (47)
- A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele (1997) (47)
- TDP-43 M337V mutation in familial amyotrophic lateral sclerosis in Japan. (2010) (47)
- Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM) (2004) (45)
- Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease (1989) (44)
- Activation of vascular endothelial cells and perivascular cells by systemic inflammation—an immunohistochemical study of postmortem human brain tissues (2004) (44)
- Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140 (2018) (44)
- Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders (1995) (44)
- Further observations on Tau-positive glia in the brains with progressive supranuclear palsy (2004) (43)
- Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues (2001) (43)
- Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in alzheimer's disease (1990) (42)
- Sporadic amyotrophic lateral sclerosis with circumscribed temporal atrophy: A report of an autopsy case without dementia and with ubiquitinated intraneuronal inclusions (2002) (41)
- 4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy (2003) (41)
- Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains (1998) (41)
- Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain (2012) (40)
- Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies (1998) (40)
- Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia (2006) (40)
- Astrocytic pathology in progressive supranuclear palsy: significance for neuropathological diagnosis (1998) (40)
- A study of dementia with argyrophilic grains Possible cytoskeletal abnormality in dendrospinal portion of neurons and oligodendroglia (2004) (39)
- Clinical Aspects of ‘Senile Dementia of the Tangle Type’ – A Subset of Dementia in the Senium Separable from Late-Onset Alzheimer’s Disease (1998) (39)
- Progranulin Reduction Is Associated With Increased Tau Phosphorylation in P301L Tau Transgenic Mice (2015) (38)
- Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy (2001) (38)
- Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions (2004) (37)
- Vascular changes in white matter lesions of Alzheimer’s disease (1999) (37)
- Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy (1995) (37)
- Both N‐terminal and C‐terminal fragments of Presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease (1998) (37)
- Immunohistochemical demonstration of glutamate dehydrogenase in astrocytes (1987) (36)
- A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles (2009) (36)
- Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients (1991) (35)
- Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia (2002) (35)
- The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease (2015) (35)
- Cortical Glutaminase, β-Glucuronidase and Glucose Utilization in Alzheimer's Disease (1989) (35)
- Intractable hiccup caused by medulla oblongata lesions: A study of an autopsy patient with possible neuromyelitis optica (2009) (34)
- FUS/TLS-Immunoreactive Neuronal and Glial Cell Inclusions Increase With Disease Duration in Familial Amyotrophic Lateral Sclerosis With an R521C FUS/TLS Mutation (2012) (34)
- Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. (2004) (34)
- Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type (1993) (33)
- Long‐term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice (2012) (32)
- Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss (2010) (32)
- Frequency and clinicopathological characteristics of alcoholic cerebellar degeneration in Japan: a cross-sectional study of 1,509 postmortems (2006) (32)
- Distinct pathways leading to TDP-43-induced cellular dysfunctions. (2014) (32)
- Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu–Hakola disease: lesion staging and dynamic changes of axons and microglial subsets (2017) (31)
- Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases (2005) (30)
- Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy (2009) (30)
- Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain? (2000) (30)
- TDP-43 pathology in familial British dementia (2009) (29)
- Immunohistochemical detection of coagulation factor XIIIa in postmortem human brain tissue (1995) (29)
- The amino-terminally truncated forms of amyloid β-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients (1996) (29)
- Involvement of microglia in Alzheimer's disease. (1994) (29)
- Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction (1994) (28)
- Tau accumulation in the nucleus accumbens in tangle-predominant dementia (2014) (28)
- Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease (1997) (28)
- Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: comparison between Gallyas and Campbell-Switzer methods (2005) (27)
- Amyotrophic lateral sclerosis with dementia: an autopsy case showing many Bunina bodies, tau-positive neuronal and astrocytic plaque-like pathologies, and pallido-nigral degeneration (2006) (27)
- Effect of topographical distribution of α-synuclein pathology on TDP-43 accumulation in Lewy body disease (2010) (27)
- An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys (1996) (27)
- A study of dementia with argyrophilic grains (1995) (27)
- Coexistence of paired helical filaments and glial filaments in astrocytic processes within ghost tangles (1992) (27)
- Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation (2017) (26)
- The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas (2007) (26)
- 3R and 4R tau isoforms in paired helical filaments in Alzheimer’s disease (2013) (26)
- TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing (2009) (25)
- A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele. (1997) (25)
- Differential diagnosis of amyotrophic lateral sclerosis from Guillain–Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid (2014) (25)
- Lewy body variant of Alzheimer’s disease or cerebral type Lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem (2007) (25)
- Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses (1997) (24)
- Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene (1997) (24)
- A high incidence of apolipoprotein E ε4 allele in middle-aged non-demented subjects with cerebral amyloid β protein deposits (1999) (23)
- Two Types of Spheroid Bodies in the Nigral Neurons in Parkinson's Disease (1991) (23)
- Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease (2002) (23)
- Age-related ubiquitin-positive granular structures in non-demented subjects and neurodegenerative disorders (1996) (23)
- Distribution of cerebello‐olivary degeneration in idiopathic late cortical cerebellar atrophy: Clinicopathological study of four autopsy cases (2008) (23)
- A pathological study of Lewy bodies and senile changes in the amygdala in diffuse Lewy body disease (1995) (23)
- Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. (2012) (22)
- Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists: Additional autopsy case with a clinical course of 19 years (2004) (22)
- Degeneration of the inferior olive in spinocerebellar ataxia 6 may depend on disease duration: Report of two autopsy cases and statistical analysis of autopsy cases reported to date (2005) (22)
- Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosis (2010) (22)
- [Loss of dendritic spines in hippocampal CA1 pyramidal cells in senescence accelerated mouse (SAM)--a quantitative Golgi study]. (1987) (22)
- An autopsy case of chronic active Epstein–Barr virus infection (CAEBV): Distribution of central nervous system (CNS) lesions (2008) (21)
- Positive florbetapir PET amyloid imaging in a subject with frequent cortical neuritic plaques and frontotemporal lobar degeneration with TDP43-positive inclusions. (2014) (20)
- Relative paucity of tau accumulation in the small areas with abundant Aβ42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology (2006) (20)
- Progressive supranuclear palsy with fronto-temporal atrophy and various tau-positive abnormal structures. (1996) (19)
- Occurrence of diffuse amyloid deposits in the presubicular parvopyramidal layer in Alzheimer's disease (2004) (19)
- Single-laser three-color immunolabeling of a histological section by laser scanning microscopy: application to senile plaque-related structures in post-mortem human brain tissue. (1995) (19)
- Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of beta-amyloid protein. (1998) (19)
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and ALS (2009) (18)
- [An autopsy case of corticobasal degeneration clinically misdiagnosed as Pick's disease]. (1995) (18)
- Corticobasal degeneration as cause of progressive non‐fluent aphasia: Clinical, radiological and pathological study of an autopsy case (2006) (17)
- White matter amyloid in Alzheimer's disease brain (2004) (17)
- Familial ALS with G298S mutation in TARDBP: a comparison of CSF tau protein levels with those in sporadic ALS. (2010) (17)
- Methenamine-silver staining: a simple and sensitive staining method for senile plaques and neurofibrillary tangles. (1994) (16)
- Complement Activation in Capillary Cerebral Amyloid Angiopathy (2018) (16)
- Choline acetyltransferase immunopositive neurons in the lateral septum (1990) (16)
- The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method. (2016) (16)
- Glial clusters and perineuronal glial satellitosis in the basal ganglia of neurofibromatosis type 1 (2008) (16)
- Loss of glutaminase-positive cortical neurons in Alzheimer's disease (1989) (16)
- “Forme fruste” of amyotrophic lateral sclerosis with dementia: A report of five autopsy cases without dementia and with ubiquitinated intraneuronal inclusions (2005) (16)
- Gain of function by phosphorylation in Presenilin 1‐mediated regulation of insulin signaling (2012) (14)
- Corticobasal degeneration initially developing motor versus non‐motor symptoms: a comparative clinicopathological study (2014) (14)
- Distinct distribution of apolipoprotein E and β-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam (1996) (14)
- Frontotemporal lobar degeneration with ubiquitin pathology: an autopsy case presenting with semantic dementia and upper motor neuron signs with a clinical course of 19 years (2006) (13)
- Alcoholic cerebellar degeneration: A clinicopathological study of six Japanese autopsy cases and proposed potential progression pattern in the cerebellar lesion (2007) (13)
- Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice (2017) (13)
- Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia (2004) (13)
- FALS with Gly72Ser mutation in SOD1 gene: Report of a family including the first autopsy case (2011) (13)
- A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits. (1999) (12)
- Pseudopolyneuritic form of ALS revisited: Clinical and pathological heterogeneity (2009) (12)
- A family with hereditary diffuse leukoencephalopathy with spheroids caused by a novel c.2442+2T>C mutation in the CSF1R gene (2016) (11)
- Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of four autopsy cases showing prominent parietal lobe involvement (2005) (11)
- ORIGINAL ARTICLE: Argyrophilic grain disease with delusions and hallucinations: a pathological study (2010) (11)
- Gray matter lesions in Nasu‐Hakola disease: A report on three autopsy cases (2011) (11)
- Argyrophilic grains are not always argyrophilic—Distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods (2005) (11)
- Immunohistochemical localization of amyloid β-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease (1999) (11)
- An atypical autopsy case of Lewy Body disease with clinically diagnosed major depression: A clinical, radiological and pathological study (2008) (11)
- Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes (2010) (10)
- [CERAD (The Consortium to Establish a Registry for Alzheimer's Disease) criteria]. (2011) (10)
- Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: A postmortem study (2012) (10)
- Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases (2006) (10)
- Frontotemporal dementia with trans‐activation response DNA‐binding protein 43 presenting with catatonic syndrome (2018) (10)
- Reactive Astrocytes Express Acidic Fibroblast Growth Factor in Alzheimer's Disease Brain (1991) (10)
- Ubiquitin-positive frontotemporal lobar degeneration presenting with progressive Gogi (word-meaning) aphasia. A neuropsychological, radiological and pathological evaluation of a Japanese semantic dementia patient (2006) (10)
- Tau progression in single severe frontal traumatic brain injury in human brains (2019) (9)
- Evidence that neurofibrillary tangles undergo glial modification (2004) (9)
- Feasibility Study: Comparison of Frontal Cortex Needle Core Versus Open Biopsy for Detection of Characteristic Proteinopathies of Neurodegenerative Diseases (2015) (9)
- Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: A non‐demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala (2007) (9)
- Bunina body in frontal lobe dementia without clinical manifestations of motor neuron disease (2001) (8)
- Novel FUS mutation in patients with sporadic amyotrophic lateral sclerosis and corticobasal degeneration (2012) (8)
- Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions (2020) (8)
- S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease (2016) (8)
- Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases (2013) (8)
- Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration (2016) (8)
- Clinicopathological study of diffuse neurofibrillary tangles with calcification With special reference to TDP-43 proteinopathy and alpha-synucleinopathy (2011) (8)
- Columnar arragement of β-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease (2004) (7)
- Familial British dementia: colocalization of furin and ABri amyloid (2003) (7)
- Autopsy case of concurrent Huntington's disease and neurofibromatosis type 1 (2014) (7)
- Metastatic CNS lymphoma presenting with periventricular dissemination — MRI and neuropathological findings in an autopsy case (2009) (6)
- Clinical features of the behavioural variant of frontotemporal dementia that are useful for predicting underlying pathological subtypes of frontotemporal lobar degeneration (2018) (6)
- [Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. (2007) (5)
- [Abeta, tau and alpha-synuclein and glial cells]. (2006) (5)
- Cryptococcal meningitis accompanying lymphocytic inflammation predominantly in cerebral deep white matter: A possible manifestation of immune reconstitution inflammatory syndrome (2014) (5)
- Atypical late-onset dementia characterized by limbic degeneration with coiled bodies and argyrophilic threads. (2003) (4)
- Atypical FTLD‐FUS associated with ALS‐TDP: A case report (2013) (4)
- Thalamic hypoperfusion in early stage of progressive supranuclear palsy(Richardson's syndrome): Report of an autopsy-confirmed case (2013) (4)
- [An autopsied case of schizophrenic patient who died from heat stroke]. (2006) (4)
- A Histochemical Study of Iron and Ferritin in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Hemiparkinsonian Monkeys (1996) (4)
- [Alzheimer's disease and the immune system response]. (1994) (4)
- [Argyrophilic grain disease clinically mimicking Parkinson's disease with dementia: report of an autopsy case]. (2004) (4)
- [An autopsy case of "progressive supranuclear palsy" without psychiatric or neurological signs]. (2004) (4)
- Japanese encephalitis - serial CT findings and neuropathology in an autopsy case. (2009) (3)
- [Development of Disease-modifying Therapy for Alzheimer's Disease]. (2016) (3)
- [Thrombin deposition in brains of patients with Alzheimer's disease--activation of the coagulation system in the central nervous system]. (1997) (3)
- 605 Senile dementia with abundant neurofibrillary tangles without accompanying senile plaques. A new disease entity separable from SDAT? (1996) (3)
- Prion-like properties of alpha-synuclein fibrils 1 Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation (2016) (3)
- Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings. (2011) (3)
- An autopsy case of familial amyotrophic lateral sclerosis with FUS R521G mutation (2014) (3)
- Morel's laminar sclerosis showing apraxia of speech: Distribution of cortical lesions in an autopsy case (2010) (3)
- [Significance of the TDP-43 deposition in FTLD-U and ALS]. (2008) (3)
- Immunohistochemical investigation of human leukocyte antigen (HLA)-DR-positive astrocytes in adrenoleukodystrophy brain (1996) (3)
- Pick’s disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke’s column, and lower motor neuron (2007) (3)
- Detection of Neurofibrillary Tangles by the Methenamine‐Silver Method: Comparison with Other Silver Stains and with Immunostaining Methods (1993) (3)
- [Glial fibrillary tangle]. (2011) (2)
- Clinicopathological study of early progressive multifocal leukoencephalopathy incidentally found in a schizophrenia patient (2009) (2)
- [Neuropathology of TDP-43 proteinopathy]. (2013) (2)
- Possible association of limbic tau pathology with psychosis or behavioral disturbances: Studies of two autopsied psychiatric patients (2022) (2)
- [TDP-43 proteinopathies, toward understanding of the molecular pathogenesis]. (2009) (2)
- [A case of argyrophilic grain dementia with emotional disorder]. (1994) (2)
- Columnar arrangement of beta-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease. (1993) (2)
- [An autopsy case of dementia lacking distinctive histology showing semantic dementia]. (2005) (2)
- TAU-IMMUNOHISTOCHEMICAL AND -IMMUNOELECTRON MICROSCOPICAL INVESTIGATION OF ASTROCYTIC PLAQUES IN PROGRESSIVE SUPRANUCLEAR PALSY (1997) (2)
- Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain (1990) (2)
- INFLAMMATIONN AND ALZHEIMER’S DISEASE (2000) (1)
- Intracellular Aβ42 deposits and neurodegeneration in Alzeimer's disease (2000) (1)
- Progressive nonfluent aphasia: A rare clinical subtype of FTLD‐TDP in Japan (2012) (1)
- [An autopsy case of senile dementia with pathological features of Parkinson's disease]. (2004) (1)
- Tau accumulation in the nucleus accumbens in tangle-predominant dementia (2014) (1)
- P1-076: Modeling Familial Danish dementia (2008) (1)
- High specificity and sensitivity of olfactory bulb synucleinopathy for Lewy body disorders (2008) (1)
- [A new dementia group caused by TDP-43 abnormality]. (2011) (1)
- [An autopsy case of argyrophilic grain dementia with abundant neurofibrillary tangles]. (2003) (1)
- Insoluble TDP-43 prepared from diseased brains has prion-like properties (2013) (1)
- A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics (2022) (1)
- Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain (2013) (1)
- Modeling familial danish dementia: Implications for the amyloid hypothesis of Alzheimer's disease (2010) (0)
- P1-140: Aggregation of phosphorylated and ubiquitinated TDP-43 in SH-SY5Y cells (2008) (0)
- 3-12-05 Possible involvement of Nedd5 in neurofibrillary pathology (1997) (0)
- Intracellular seeded aggregation and cytotoxic model of TDP-43 (2012) (0)
- The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease (2015) (0)
- [Frontotemporal dementia (FTD) and genetic mutations including progranulin gene]. (2008) (0)
- Astrocytes as a small metabolic pool of glutamate: An immunohistochemical study in the rat (1988) (0)
- Abstracts for the 6th Congress of Asian Sleep Research Society (2009) (0)
- Complement in human capillary cerebral amyloid angiopathy (2017) (0)
- Tau Pathology of Sporadic Tauopathies (2004) (0)
- [LRP (alpha 2-macroglobulin receptor) and Alzheimer lesions]. (1996) (0)
- 419 Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein (1996) (0)
- Pathological and biochemical study of the nucleus accumbens in tangle-predominant dementia (2013) (0)
- Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders (2011) (0)
- Title The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer ' s disease (2016) (0)
- [Gliosis and activated microglia]. (2011) (0)
- P4-157 Accumulation of phosphorylated alpha-synuclein and tau in Alzheimer’s disease and dementia with Lewy bodies (2006) (0)
- A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics (2022) (0)
- Screening of the SOD1, TARDBP and FUS mutations and the pathological studies in Japanese cases with familial and sporadic amyotrophic lateral sclerosis (2012) (0)
- Analysis of an Aβ-like peptide in CSF to reveal whether and how the cleavage precision of presenilin/γ-secretase is altered in AD patients (2009) (0)
- Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions (2020) (0)
- Proteomic analyses of TDP-43 proteinopathy (2010) (0)
- Pathological role of GBA2 in GBA1-deficient neuronopathic Gaucher’s disease model of medaka (2017) (0)
- Pathological alpha-synuclein propagates through neural networks (2014) (0)
- Phosphorylated TDP-43 in neurodegenerative disorders (2009) (0)
- PT581. Multiple accumulation of neurodegenerative disease-related proteins in familial granulin mutation brains (2016) (0)
- An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia (2021) (0)
- Tau pathology in the parahippocampal region is related to delusion in the elderly: Neuropathological study of two autopsy cases (2013) (0)
- Cortical Glutaminase , ( 3-Glucuronidase and Glucose Utilization in Alzheimer ' s Disease (2014) (0)
- [Dementia: progress in diagnosis and treatment: topics, V. Recent topics; 4. Detection of novel dementia-related genes; 1) TDP-43]. (2011) (0)
- P2-192: Accumulation of phosphorylated TDP-43 in neurodegenerative disorders (2008) (0)
- Effects of presenilin 1 phosphorylation on insulin receptor (2010) (0)
- Neuropathological diagnosis of progressive supranuclear palsy and related disorders. (1996) (0)
- Early diagnosis of Alzheimer's type dementia with special reference to the clinicopathology of mild cognitive impairment (2004) (0)
- [Registries to Boost the Clinical Trials for the Disease Modifying Therapy of Alzheimer's Disease]. (2017) (0)
- [Molecular dissection of TDP-43 in ALS and FTLD]. (2010) (0)
- Amyloid β–protein granules in glial cells in Alzheimer’s disease brain (2001) (0)
- Open peer commentary Inflammation and Alzheimer's disease (2000) (0)
- Title : iPSC-based drug repositioning identifies the Src / c-Abl pathway as a therapeutic target for ALS motor neurons (2017) (0)
- PHOSPHORYLATED TAU AND ALPHA-SYNUCLEIN ACCUMULATION IN FAMILIAL GRANULIN MUTATION CASES (2016) (0)
- Development of TDP-43 proteinopathy model mice (2017) (0)
- Methylene blue reduced tau phosphorylation and aggregation in P301L tau transgenic mice (2012) (0)
- MEETING REPORT (1996) (0)
- [A 71 year-old man with progressive dysarthria]. (2013) (0)
- Phenotypes of A-beta granule-containing glial cells in the brain of Alzheimer's disease (2000) (0)
- [Role of Complements in the Pathogenesis of Alzheimer's Disease]. (2019) (0)
- Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration (2016) (0)
- C-terminal TDP-43 inclusion suppresses proliferation mediated by transcriptional dysregulation (2011) (0)
- Morphological analysis of human tau transgenic mice showing age-dependent learning disorders (2007) (0)
- [Prion-like protein propagation in neurodegenerative diseases]. (2012) (0)
- Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation (2017) (0)
- [Autopsy case of Lewy body dementia associated with abundant argyrophilic grains]. (2005) (0)
- 280 Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy (1996) (0)
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What Schools Are Affiliated With Haruhiko Akiyama?
Haruhiko Akiyama is affiliated with the following schools:
