Heidi E. Hamm

Q: What Schools Are Affiliated With Heidi E. Hamm

Heidi E. Hamm is affiliated with the following schools: Weizmann Institute of Science, Icahn School of Medicine at Mount Sinai, Northwestern University, Vanderbilt University, University of Illinois College of Medicine, University of Chicago, Stanford University, University of California, San Francisco, Duke University

Heidi E. Hamm's AcademicInfluence.com Rankings

Heidi E. Hamm

Medical

#2005

World Rank

#2394

Historical Rank

Pharmacology

#202

World Rank

#242

Historical Rank

medical Degrees

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Medical

Heidi E. Hamm's Degrees

PhD Pharmacology University of California, San Francisco
Doctorate Medicine Stanford University

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Heidi E. Hamm's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Many Faces of G Protein Signaling* (1998) (1173)
The 2.0 Å crystal structure of a heterotrimeric G protein (1996) (1155)
Heterotrimeric G protein activation by G-protein-coupled receptors (2008) (1029)
Insights into G protein structure, function, and regulation. (2003) (707)
The 2.2 Å crystal structure of transducin-α complexed with GTPγS (1993) (648)
Crystal structure of a GA protein βγdimer at 2.1 Å resolution (1996) (619)
The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. (1994) (562)
Structural determinants for activation of the α-subunit of a heterotrimeric G protein (1994) (541)
D2 Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+ Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade (2000) (511)
GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4 (1994) (485)
Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. (1988) (469)
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors (1998) (436)
Heterotrimeric G proteins. (1996) (350)
Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway (2000) (307)
Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions* (1997) (284)
Retinal rhythms in chicks: circadian variation in melantonin and serotonin N-acetyltransferase activity. (1980) (284)
A Novel Bifunctional Phospholipase C That Is Regulated by Gα12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway* (2001) (278)
Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro. (1980) (253)
Structural basis of function in heterotrimeric G proteins (2006) (239)
RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion (2006) (237)
G Protein βγ Subunit-Mediated Presynaptic Inhibition: Regulation of Exocytotic Fusion Downstream of Ca2+ Entry (2001) (235)
Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. (1996) (223)
How activated receptors couple to G proteins (2001) (205)
Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1*[boxs] (2005) (189)
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins (2006) (175)
Crystal structure of a G-protein βγ dimer at 2.1 Å resolution (1996) (175)
NMR structure of a receptor-bound G-protein peptide (1993) (173)
Erythrocyte G Protein-Coupled Receptor Signaling in Malarial Infection (2003) (166)
Gβγ acts at the C terminus of SNAP-25 to mediate presynaptic inhibition (2005) (162)
Structural and functional relationships of heterotrimeric G‐proteins (1995) (162)
A blue-light-activated GTP-binding protein in the plasma membranes of etiolated peas. (1991) (162)
G protein βγ directly regulates SNARE protein fusion machinery for secretory granule exocytosis (2005) (160)
Potent Peptide Analogues of a G Protein Receptor-binding Region Obtained with a Combinatorial Library (*) (1996) (154)
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit (2011) (149)
Protein complement of rod outer segments of frog retina. (1986) (148)
Mapping of Effector Binding Sites of Transducin α-Subunit Using Gαt/Gαil Chimeras (*) (1996) (140)
Molecular basis for interactions of G protein betagamma subunits with effectors. (1998) (136)
Arrestin-rhodopsin interaction. Multi-site binding delineated by peptide inhibition. (1994) (136)
Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. (1994) (130)
Thrombin Induces Proteinase-activated Receptor-1 Gene Expression in Endothelial Cells via Activation of Gi-linked Ras/Mitogen-activated Protein Kinase Pathway* (1999) (128)
Synthetic peptides as probes for G protein function. Carboxyl-terminal G alpha s peptides mimic Gs and evoke high affinity agonist binding to beta-adrenergic receptors. (1994) (125)
Interaction of rhodopsin with the G‐protein, transducin (1993) (122)
Regulation of transducin GTPase activity in bovine rod outer segments. (1994) (122)
PAR4, but Not PAR1, Signals Human Platelet Aggregation via Ca2+ Mobilization and Synergistic P2Y12 Receptor Activation* (2006) (121)
G protein betagamma subunit-mediated presynaptic inhibition: regulation of exocytotic fusion downstream of Ca2+ entry. (2001) (118)
Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP. (2006) (118)
GPCR mediated regulation of synaptic transmission (2012) (117)
Essential roles of Gα12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements (2005) (114)
Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling. (2006) (108)
Gα Minigenes Expressing C-terminal Peptides Serve as Specific Inhibitors of Thrombin-mediated Endothelial Activation* (2001) (107)
RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons. (2004) (105)
Calcium and cyclic GMP regulation of light-sensitive protein phosphorylation in frog photoreceptor membranes (1982) (99)
Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina (1983) (93)
A Dominant-Negative Strategy for Studying Roles of G Proteins in Vivo * (1999) (93)
Antagonists of the Receptor-G Protein Interface Block Gi-coupled Signal Transduction* (1998) (93)
The βγ Subunit of Heterotrimeric G Proteins Interacts with RACK1 and Two Other WD Repeat Proteins* (2002) (92)
A site on rod G protein alpha subunit that mediates effector activation. (1992) (91)
PAR1, but Not PAR4, Activates Human Platelets through a Gi/o/Phosphoinositide-3 Kinase Signaling Axis (2007) (90)
Phosducin‐like protein acts as a molecular chaperone for G protein βγ dimer assembly (2005) (89)
Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective. (2013) (88)
GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. (1995) (84)
Structural analysis of rod GTP-binding protein, Gt. Limited proteolytic digestion pattern of Gt with four proteases defines monoclonal antibody epitope. (1991) (84)
G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis. (2005) (82)
Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription. (2007) (81)
G Protein Signaling: Insights from New Structures (2004) (80)
Gβγ Interferes with Ca2+-Dependent Binding of Synaptotagmin to the Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (SNARE) Complex (2007) (79)
Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy (2006) (76)
How do receptors activate G proteins? (2007) (74)
Gbetagamma acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. (2005) (74)
Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. (2009) (74)
Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase. (1992) (72)
Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway (2006) (71)
Interaction of Gβγ with RACK1 and other WD40 repeat proteins (2004) (70)
The α-Helical Domain of Gαt Determines Specific Interaction with Regulator of G Protein Signaling 9* (1999) (69)
Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism. (1992) (69)
Aspartic Acid 564 in the Third Cytoplasmic Loop of the Luteinizing Hormone/Choriogonadotropin Receptor Is Crucial for Phosphorylation-independent Interaction with Arrestin2* (2002) (67)
Energetic analysis of the rhodopsin–G-protein complex links the α5 helix to GDP release (2013) (66)
G protein βγ-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties (2006) (65)
Gpr125 modulates Dishevelled distribution and planar cell polarity signaling (2013) (65)
Regulation by light of cyclic nucleotide-dependent protein kinases and their substrates in frog rod outer segments (1990) (63)
Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins (2007) (63)
Thrombin Modulates the Expression of a Set of Genes Including Thrombospondin-1 in Human Microvascular Endothelial Cells* (2005) (63)
An Effector Site That Stimulates G-protein GTPase in Photoreceptors (*) (1995) (63)
Gα12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton (2009) (62)
Conformational Changes in the Amino-Terminal Helix of the G Protein αi1 Following Dissociation From Gβγ Subunit and Activation (2002) (62)
Protease-Activated Receptor Signaling in Platelets Activates Cytosolic Phospholipase A2&agr; Differently for Cyclooxygenase-1 and 12-Lipoxygenase Catalysis (2011) (61)
Thrombin Receptors Activate Go Proteins in Endothelial Cells to Regulate Intracellular Calcium and Cell Shape Changes* (2002) (61)
RACK1 Regulates Specific Functions of Gβγ* (2004) (61)
Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling* (2003) (59)
Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin. (1987) (58)
Functional Roles of the Two Domains of Phosducin and Phosducin-like Protein* (2000) (57)
RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. (2008) (57)
Specific peptide probes for G-protein interactions with receptors. (1994) (56)
Modulation of the G Protein Regulator Phosducin by Ca2+/Calmodulin-dependent Protein Kinase II Phosphorylation and 14-3-3 Protein Binding* (2001) (56)
The Carboxyl Terminus of the γ-Subunit of Rod cGMP Phosphodiesterase Contains Distinct Sites of Interaction with the Enzyme Catalytic Subunits and the α-Subunit of Transducin (*) (1995) (56)
Mathematical model of the spatio-temporal dynamics of second messengers in visual transduction. (2003) (55)
Protease-Activated Receptor (PAR) 1 and PAR4 Differentially Regulate Factor V Expression from Human Platelets (2013) (54)
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation (2018) (54)
Activation of transducin guanosine triphosphatase by two proteins of the RGS family. (1997) (54)
Interaction of Transducin with Light-activated Rhodopsin Protects It from Proteolytic Digestion by Trypsin* (1996) (54)
Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction. (2008) (54)
Gβγ Binds Histone Deacetylase 5 (HDAC5) and Inhibits Its Transcriptional Co-repression Activity* (2005) (53)
Gβγ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity (2010) (52)
Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin. (1987) (49)
Structural Requirements for the Stabilization of Metarhodopsin II by the C Terminus of the α subunit of Transducin* (2001) (47)
Dendritic molecular transporters provide control of delivery to intracellular compartments. (2007) (47)
Gα COOH-Terminal Minigene Vectors Dissect Heterotrimeric G Protein Signaling (2002) (47)
Conformational Changes at The Carboxyl Terminus of Gα Occur during G Protein Activation* (1999) (47)
DEP domains: More than just membrane anchors. (2006) (46)
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. (2002) (45)
The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution. (2003) (45)
Mechanism of photoreceptor cGMP phosphodiesterase inhibition by its gamma-subunits. (1996) (45)
Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway (2007) (44)
Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. (2005) (44)
RACK1 Binds to a Signal Transfer Region of Gβγ and Inhibits Phospholipase C β2 Activation* (2005) (43)
Rhodopsin Expression Level Affects Rod Outer Segment Morphology and Photoresponse Kinetics (2012) (43)
A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein α Subunit* (2014) (41)
A site on transducin alpha-subunit of interaction with the polycationic region of cGMP phosphodiesterase inhibitory subunit. (1993) (41)
Activation of the Luteinizing Hormone/Choriogonadotropin Hormone Receptor Promotes ADP Ribosylation Factor 6 Activation in Porcine Ovarian Follicular Membranes* (2001) (41)
The role of coagulation and platelets in colon cancer-associated thrombosis. (2019) (39)
Modulation of Neurotransmission by GPCRs Is Dependent upon the Microarchitecture of the Primed Vesicle Complex (2014) (38)
Two Amino Acids within the α4 Helix of Gαi1Mediate Coupling with 5-Hydroxytryptamine1BReceptors* (1999) (38)
Direct Modulation of Phospholipase D Activity by Gβγ (2006) (38)
Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins. (2004) (37)
Identification of key factors that reduce the variability of the single photon response (2011) (36)
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. (2014) (36)
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity (2016) (36)
G protein betagamma subunits modulate the number and nature of exocytotic fusion events in adrenal chromaffin cells independent of calcium entry. (2008) (35)
RACK1 regulates specific functions of Gbetagamma. (2004) (35)
Gβγ Inhibits Exocytosis via Interaction with Critical Residues on Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein-25 (2012) (33)
Preparation and characterization of monoclonal antibodies to several frog rod outer segment proteins (1984) (33)
Subunit Structure of Rod cGMP-Phosphodiesterase* (1996) (33)
Irreversible Platelet Activation Requires Protease-Activated Receptor 1-Mediated Signaling to Phosphatidylinositol Phosphates (2009) (33)
A monoclonal antibody to guanine nucleotide binding protein inhibits the light-activated cyclic GMP pathway in frog rod outer segments (1984) (32)
Modeling the role of incisures in vertebrate phototransduction. (2006) (32)
A Gαs Carboxyl-Terminal Peptide Prevents Gs Activation by the A2A Adenosine Receptor (2000) (32)
G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties. (2006) (31)
Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo (2012) (31)
Mathematical model of PAR1-mediated activation of human platelets. (2011) (29)
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes (2019) (29)
Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets (2013) (29)
Coupling efficiency of rhodopsin and transducin in bicelles. (2011) (28)
Dynamics of mouse rod phototransduction and its sensitivity to variation of key parameters. (2010) (27)
Design and use of C-terminal minigene vectors for studying role of heterotrimeric G proteins. (2002) (27)
A Specific Domain of Giα Required for the Transactivation of Giα by Tubulin Is Implicated in the Organization of Cellular Microtubules* (2003) (26)
Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein–Coupled Receptors (2016) (26)
Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes (2017) (26)
Mathematical and computational modelling of spatio-temporal signalling in rod phototransduction. (2005) (25)
Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets (2017) (25)
G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity. (2005) (25)
Kinetics of Rhodopsin Deactivation and Its Role in Regulating Recovery and Reproducibility of Rod Photoresponse (2010) (25)
Heterosynaptic GABAB Receptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core (2019) (24)
Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. (2009) (24)
Differential Localization of G Protein βγ Subunits (2014) (23)
Regulation of Protease-Activated Receptor (PAR) 1 and PAR4 Signaling in Human Platelets by Compartmentalized Cyclic Nucleotide Actions (2007) (23)
Effect of Li+ upon the Mg2+-Dependent Activation of Recombinant Giα1 (2001) (22)
RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation. (2005) (22)
Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor* (2016) (22)
The expanding roles and mechanisms of G protein–mediated presynaptic inhibition (2019) (21)
Effect of monoclonal antibody binding on alpha-beta gamma subunit interactions in the rod outer segment G protein, Gt. (1989) (21)
Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins. (2008) (21)
Trp fluorescence reveals an activation‐dependent cation‐π interaction in the Switch II region of Gαi proteins (2009) (21)
Suboptimal Activation of Protease-activated Receptors Enhances α2β1 Integrin-mediated Platelet Adhesion to Collagen* (2009) (21)
Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions (2019) (21)
Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation. (2002) (20)
Light-dependent GTP-binding proteins in squid photoreceptors. (1990) (20)
G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor (2018) (19)
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor * (2016) (19)
Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation. (2004) (18)
Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles (2018) (17)
Two amino acids within the alpha4 helix of Galphai1 mediate coupling with 5-hydroxytryptamine1B receptors. (1999) (17)
Tryptophan207 is involved in the GTP-dependent conformational switch in the α subunit of the G protein transducin: Chymotryptic digestion patterns of the GTPγS and GDP-bound forms (1993) (17)
Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. (2012) (16)
NMR structure of a receptor-bound G-protein peptide (1997) (16)
The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9. (1999) (16)
The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses (2019) (15)
Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective. (2012) (15)
Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation. (2015) (15)
How Gsα activates adenylyl cyclase (1998) (15)
GPCR regulation of secretion. (2018) (15)
Quantitative Multiple-Reaction Monitoring Proteomic Analysis of Gβ and Gγ Subunits in C57Bl6/J Brain Synaptosomes. (2017) (14)
Label-free detection of G protein-SNARE interactions and screening for small molecule modulators. (2012) (14)
A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina (2017) (14)
2010 Young Investigator Award Winner: Therapeutic Aprotinin Stimulates Osteoblast Proliferation but Inhibits Differentiation and Bone Matrix Mineralization (2010) (13)
Linking receptor activation to changes in Sw I and II of Gα proteins. (2013) (13)
Pineal and Retinal Serotonin N‐Acetyltransferase Activity: Modulation by Phosphate (1981) (13)
Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa (2018) (13)
G protein βγ subunits modulate the number and nature of exocytotic fusion events in adrenal chromaffin cells independent of calcium entry (2008) (11)
G protein βγ subunits modulate the number and nature of exocytotic fusion events in adrenal chromaffin cells independent of calcium entry (2008) (11)
A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in Gαi1* (2014) (10)
Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin. (2016) (10)
G‐protein‐coupled receptors: evolving views on physiological signalling (2006) (10)
The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III. (2014) (10)
Disturbing Gtp-Binding Protein Function Through Microinjection Into The Visual Cell Of Limulus (1992) (9)
Tryptophan207 is involved in the GTP-dependent conformational switch in the alpha subunit of the G protein transducin: chymotryptic digestion patterns of the GTP gamma S and GDP-bound forms. (1993) (9)
Calmodulin binding distinguishes between βγ subunits of activated G proteins and transducin (1992) (9)
An intramolecular contact in Galpha transducin that participates in maintaining its intrinsic GDP release rate. (2001) (9)
The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin. (1995) (9)
A Novel and Selective PAR4 Antagonist: ML354 (2015) (9)
Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention (2016) (9)
A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. (2014) (8)
Energetic analysis of the R*-G complex links the α5 helix to GDP release and domain opening (2013) (8)
Erratum: Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway (Molecular Pharmacology (2007) 71 (686-694)) (2009) (8)
Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release (2022) (8)
A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. (2003) (8)
Permeable Cell Systems as Models for Studying Disruption, by Site-Specific Synthetic Peptides, of Receptor–G Protein–Effector Coupling (1993) (8)
A galpha(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor. (2000) (8)
Molecular interactions between the photoreceptor G protein and rhodopsin (1991) (8)
Using peptide arrays created by the SPOT method for defining protein-protein interactions. (2015) (7)
Surfaces of interaction between Gt and rhodopsin in the GDP-bound and empty-pocket configurations. (1990) (7)
Mapping of Effector Binding Sites of Transducin a-Subunit Using Gat/Gai1 Chimeras* (1995) (7)
A monoclonal antibody against the rod outer segment guanyl nucleotide-binding protein, transducin, blocks the stimulatory and inhibitory G proteins of adenylate cyclase. (1989) (7)
Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation (2013) (7)
Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus (2019) (6)
Extracellular Loop II Modulates GTP Sensitivity of the Prostaglandin EP3 Receptor (2013) (6)
Correction to Helix Dipole Movement and Conformational Variability Contribute to Allosteric GDP Release in Gαi Subunits (2010) (6)
Fracture healing in protease‐activated receptor‐2 deficient mice (2012) (6)
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles. (2016) (6)
[34] GαtGαil chimeras used to define structural basis of specific functions of Gαt (2000) (6)
Numerical Simulation of Diffusion of Second Messengers cGMP and Ca2+ in Rod Photoreceptor Outer Segment of Vertebrates (2003) (6)
Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study (2020) (6)
Effect of Li+ upon the Mg2+-dependent activation of recombinant Gialpha1. (2001) (6)
RACK1 Regulates Directional Cell Migration by Acting on G (cid:1)(cid:2) at the Interface with Its Effectors PLC (cid:1) and PI3K (cid:2) (2008) (6)
Proteolytic fragmentation for epitope mapping. (1996) (5)
Rod cGMP-Phosphodiesterase γ-Subunit: Structure–Function Relationships (1993) (5)
Gβγ SNARE Interactions and Their Behavioral Effects (2019) (5)
Disabling Gβγ SNARE interaction in transgenic mice disrupts GPCR-mediated presynaptic inhibition leading to physiological and behavioral phenotypes (2018) (5)
Heterotrimeric G Protein Cycle (2004) (4)
Physiological roles for neuromodulation via Gi/o GPCRs working through Gβγ–SNARE interaction (2019) (3)
Cyclic AMP-dependent phosphoprotein components I and II interact with beta gamma subunits of transducin in frog rod outer segments. (1996) (3)
Racial Differences in Resistance to P2Y12 Receptor Antagonists in Type 2 Diabetic Subjects (2014) (3)
Dissecting receptor-G protein specificity using G alpha chimeras. (2002) (3)
Specific peptide probes for G-protein interaction with effectors. (1994) (3)
The molecular basis of GTP-binding protein interaction with receptors. (1990) (3)
Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods (2019) (3)
Visual transduction in vertebrate photoreceptors. Light activation of guanylate cyclase. (1989) (3)
PAR1, but not PAR4, regulates human platelet activation through PLD (2006) (2)
Phototransduction in retinal cones: Analysis of parameter importance (2021) (2)
Critical Residues of Gβγ for the interaction with the SNARE Complex (2020) (2)
CHAPTER 61 – G-Protein Organization and Signaling (2003) (2)
Position of rhodopsin photoisomerization on the disk surface confers variability to the rising phase of the single photon response in vertebrate rod photoreceptors (2020) (2)
How Gsalpha activates adenylyl cyclase. (1998) (2)
Defining G protein beta gamma specificity for effector recognition. (2002) (2)
G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t. (2000) (2)
Sexual Dimorphism in Stress‐induced Hyperthermia in SNAP25Δ3 mice, a mouse model with disabled Gβγ regulation of the exocytotic fusion apparatus (2019) (2)
Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α2a-adrenergic receptors (2021) (2)
Structural characterization of intact G protein gamma subunits by mass spectrometry. (2002) (2)
Proteolytic fragmentation for epitope mapping. (2009) (2)
Effect of Li 1 upon the Mg 21 -Dependent Activation of Recombinant G ia1 (2001) (2)
G Protein Preassembly Rescues Efficacy of W Toggle Mutations in Neuropeptide Y2 Receptor s (2018) (2)
Irreversible Platelet Activation Requires PAR1 Regulation of Phosphatidylinositol Phosphates (PIPns) Activation of Rap1. (2007) (1)
A survey of conformational and energetic changes in G protein signaling (2015) (1)
Endothelial Nitric-Oxide Synthase Reveals a New Face in G Protein Signaling (2006) (1)
Molecular Determinants of GPCR-G Protein Complex Formation (2012) (1)
The specificity of Gβγ subunits regulating exocytosis through the adrenergic α2a receptor (2015) (1)
Binds to the Extreme C Terminus of SNAP 25 to Mediate the Action of Gi / o-Coupled G Protein – Coupled Receptors (2015) (1)
Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles. (2015) (1)
Gbg Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein–Coupled Receptors (2015) (1)
Visual transduction in vertebrate photoreceptors (1989) (1)
Protease-Activated Receptor ( PAR ) 1 and PAR 4 Differentially Regulate Factor V Expression from Human Platelets s (2013) (1)
Fluctuations of the Single Photon Response in Visual Transduction (2005) (1)
Physical Studies of α-βγ Subunit Interactions of the Rod Outer Segment G Protein, Gt: Effects of Monoclonal Antibody Binding (1990) (1)
Calmodulin binding distinguishes between beta gamma subunits of activated G proteins and transducin. (1992) (1)
Probing G-protein function (1994) (1)
Calcium Mobilization in Human Platelets is Differentially Modulated by PAR‐1 and PAR‐4 through Gi/o and PI3K (2006) (1)
SNAP25 differentially contributes to Gi/o-coupled receptor function at glutamatergic synapses in the nucleus accumbens (2023) (0)
Abstract 15221: Protease Activated Receptor-4 Induces Expression of More Platelet-Derived Factor V and Factor VIII than Protease Activated Receptor-1 Leading to Enhanced Thrombin Generation (2011) (0)
Impairment of the Gβγ-SNAP25 brake on exocytosis enhances insulin action, protects against diet-induced obesity, and promotes adipocyte browning (2020) (0)
Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa (2018) (0)
Figure 5, PAR4 and PAR1 CRC for ML354 (VU0099704) (2015) (0)
Gpr125 - a novel planar cell polarity pathway component in zebrafish (2011) (0)
Thrombin receptor signaling regulates platelet adhesion to collagen (2007) (0)
PI‐3K differentially regulates protease activated receptor‐mediated platelet activation in humans through Rap1 (2007) (0)
Coupling Efficiency of Rhodopsin and Transducin in the Bicelle Mixtures (2010) (0)
Loss of serotonin transporter function alters ADP‐mediated αIIbβ3 activation through disregulation of 5HT2A receptor (2016) (0)
Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity (2022) (0)
1064-181 Distinct signaling pathways mediate protease activated receptor-dependent endothelial exocytosis (2004) (0)
Ga12/13 signaling regulates epiboly by inhibiting E‐cadherin function (2006) (0)
G βγ binds to the extreme C-terminus of SNAP25 to mediate the action of G i/o -coupled GPCRs. (2015) (0)
MOL # 29371 2 Running Title : PA regulation of PAR 1 versus PAR 4 in platelets (2006) (0)
Systematic study of dominant negative Gα C-terminal minigenes delineate G protein pathways in thrombin-mediated responses of endothelial cells (2000) (0)
PAR1‐mediated stable platelet aggregation requires temporal regulation of Rap1 activity by phosphatidylinositol phosphates (PIPns). (2008) (0)
A series of substituted isoindolinones as selective small molecule modulators of the Gβγ‐SNARE interaction (2016) (0)
Structural characterization of the Gβγ–ternary SNARE binding interface (2021) (0)
Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GTPgammaS (2014) (0)
SUMO-binding Sites in Mouse Nrf 2 : Impact on the Transcriptional Activity of Nrf 2 (2016) (0)
Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1 (2016) (0)
Defining Sites and Mechanisms of Interaction Between Rhodopsin and Transducin (1991) (0)
Myristoylation and its role in conformational changes associated with Galphai subunit activation (2009) (0)
Mutant thrombin receptor activating peptide induces unique coupling of PAR-1 receptor to G proteins. (2007) (0)
Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS (2016) (0)
Abstract 11336: Racial Differences in Resistance to P2Y12 Receptor Antagonists in Thrombin-Stimulated Diabetic Platelets (2011) (0)
G βγ interferes with Ca 2 +-dependent binding of synaptotagmin to the SNARE complex (2007) (0)
Platelet Microparticle Production Is Regulated By STIM1 Dependent Entry Of Extracellular Ca2+ Through Orai1 (2013) (0)
Receptor‐activation opens the door to GDP release in Heterotrimeric G proteins (2011) (0)
Fluorescent probes as indicators of conformation changes in transducin on activation. (2000) (0)
G{beta}{gamma} mediated modulation of exocytosis downstream of Ca2+ entry in bovine adrenal chromaffin cells (2007) (0)
Pepperberg plot: Modeling flash response saturation in retinal rods of mouse (2023) (0)
Coagulation Cofactor Presentation and Complex Assembly on Platelets by Protease Activated Receptors (PARs): PAR4 Stimulation Leads to More FV and FVIII and More Thrombin Generation Than PAR1 (2011) (0)
Abstract 572: Serotonin and Selective Serotonin Reuptake Inhibitors in Platelet Function and RhoA Activation (2014) (0)
Author Correction: The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses (2019) (0)
Activation of transducin gtpase by two proteins from the rgs family (1997) (0)
Regulation of heterotrimeric G protein {beta}{gamma} subunits mediated PI3K activation and leukocyte migration through a novel WD40-WD40 repeat interaction between RACK1 and G{beta}{gamma} (2007) (0)
Studying the potential dual role of adhesion G protein-coupled receptors in early zebrafish embryogenesis (2010) (0)
SPECTROSCOPIC STUDIES ( EPR , NMR ) MP 4 l APPLICATIONS OF MAGNETICALLY COUPLED RELAXATION SPECTROSCOPY TO UNDERSTANDING MAGNETIC RELAXATION IN TISSUES AND PROTEIN SYSTEMS (2005) (0)
Protease Activated Receptors Differentially Regulate Human Platelet Activation through Phosphatidic Acid-Dependent DAG Formation. (2006) (0)
Carboxyl-Terminal Peptide Prevents Gs Activation by the A 2 A Adenosine Receptor (2000) (0)
Role of G{beta}{gamma} in regulation of class II histone deacetylases (2010) (0)
The scaffolding protein RACK1 functions in IP3–dependent cellular processes in the nematode C. elegans (2006) (0)
How do GPCRs Catalyze G Protein Activation? (2009) (0)
An intramolecular binding site for the myristoylated amino-terminus of G{alpha}i (2008) (0)
A dominant negative approach for characterization of the G-proteins mediating histamine H2 receptor signaling (2001) (0)
Crystal Structure of the G Protein Fast-Exchange Double Mutant I56C/Q333C (2009) (0)
Regulation of PAR1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions (2007) (0)
An intramolecular binding site for the myristoylated amino‐terminus of Gαi (2008) (0)
Gbetagamma interacts with enzymes involved in reversible protein acetylation (2006) (0)
Abstract 55: Chronic Loss of Serotonin Transporter Function Alters Platelet Adhesion and Spreading (2015) (0)
The molecular requirements for the G protein betagamma‐SNARE interaction (2015) (0)
HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS (1997) (0)
RACK1 negatively regulates SDF1α/CXCL12‐stimulated chemotaxis of Jurkat cells (2006) (0)
Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors. (2021) (0)
Gβγ reduces the number and quantal size of exocytotic events in neurosecretory chromaffin cells (2006) (0)
Refined structures of heterotrimeric G protein complexes at high resolution (1996) (0)
G protein βγ subunits bind to and inhibit the function of multiple Qa- and Qb,c-SNARE isoforms (2022) (0)
Role of Gβγ in regulation of class II histone deacetylases (2010) (0)
Regulation of heterotrimeric G protein βγ subunits mediated PI3K activation and leukocyte migration through a novel WD40‐WD40 repeat interaction between RACK1 and Gβγ (2007) (0)
G protein specificity of inhibitory adrenergic a2a receptor‐mediated modulation of synaptic transmission (2017) (0)
Revamped Outer Segment Structure and Photoresponse in Retinal Rods Over-expressing Rhodopsin (2009) (0)
Identification of the key parameters in a mathematical model of PAR1-mediated signaling in endothelial cells (2011) (0)
Specificity of Gβ and γ subunits to the SNARE complex both at rest and after α2a adrenergic receptor stimulation (2020) (0)
Modulation of Synaptic Transmission by G Protein {beta}{gamma} Subunits (2009) (0)
Gβγ SNARE Interactions and Their Behavioral Effects (2018) (0)
Collybolide is a Highly Selective and Potent Agonist of Kappa Opioid Receptors (2015) (0)
BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN (1997) (0)
Current progress on crystallographic complexes of transducin (1996) (0)
Thrombin‐mediated thromboxane and 12‐HETE formation in human platelets is differentially regulated through PAR1 and PAR4 (2009) (0)
Modulation of Synaptic transmission: Quantitative analysis of Gβγ specificity to adrenergic α2a receptor and SNARE. (2018) (0)
The specificity of Gβγ subunits regulating exocytosis through the Gi/o‐coupled α2a adrenergic receptor (2016) (0)
GPCR‐mediated Modulation Of Synaptic Transmission (2012) (0)
The crystal structure of the fast exchange mutant I56C/Q333C in Gαi1 suggests a mechanism for receptor‐mediated allosteric nucleotide exchange (2007) (0)
Author Correction: The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses (2020) (0)
Structural basis of receptor‐dependent G protein activation (2006) (0)
Modulation of Synaptic Transmission by G Protein βγ Subunits (2009) (0)
Mathematical aspects of Variability and Variability Suppression of the Single Photon Response in Vertebrate Phototransduction (2009) (0)
Molecular basis for gβγ-effector interaction: Structural correlation with ga binding site (1997) (0)
Effects of cell size and bicarbonate on single photon response variability in retinal rods (2022) (0)
Use of peptides-on-plasmids combinatorial library to identify high-affinity peptides that bind rhodopsin. (2000) (0)
Locating an intramolecular binding site for the myristoylated N-terminus of Galphai (2007) (0)
Mechanism of Receptor‐mediated G protein Activation (2006) (0)
Communicating a Nobel Signal: Exploration of the Heterotrimeric G protein (2013) (0)

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