Heidi Wunderli-Allenspach
Swiss biologist and professor at the Swiss Federal Institute of Technology Zurich
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Biology
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(Suggest an Edit or Addition)According to Wikipedia, Heidi Wunderli-Allenspach is a Swiss biologist and was the first female director of ETH Zürich. Life and work Wunderli-Allenspach was born in 1947 in Niederuzwil in the Canton of St. Gallen in Switzerland. She graduated with the master's degree in biology at ETH Zurich in 1970, and then she worked as a research assistant at the Institute for Brain Research at the University of Zurich. Thenafter she postgraduatedin Experimental Medicine and Biology at the University of Zurich. Wunderli subsequently did her Ph.D. thesis at the Department of Microbiology at the Biozentrum in Basel, and as research associate at the Department of Surgery, Duke University Medical Center, Durham NC, from 1976 to 1978 in the USA. Between 1978 and 1981 she worked as a postdoctoral fellow at the Swiss Institute for Experimental Cancer Research in Lausanne, and from 1981 to 1984 at the Institute for Immunology and Virology of the University of Zurich.
Heidi Wunderli-Allenspach's Published Works
Published Works
- Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages? (2001) (283)
- P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. (1998) (217)
- Cell cultures as tools in biopharmacy. (2000) (155)
- Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common gamma chain. (1996) (149)
- Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia (2006) (147)
- Quantitation of the tumor-targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides. (2002) (130)
- Dynamics of Tight and Adherens Junctions Under EGTA Treatment (2002) (112)
- Transfer of Lipophilic Markers from PLGA and Polystyrene Nanoparticles to Caco-2 Monolayers Mimics Particle Uptake (2002) (101)
- Novel peptide conjugates for tumor-specific chemotherapy. (2001) (97)
- Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies (2006) (95)
- Phenotypic characterization of human umbilical vein endothelial (ECV304) and urinary carcinoma (T24) cells: Endothelial versus epithelial features (2001) (95)
- No entry for TAT(44-57) into liposomes and intact MDCK cells: novel approach to study membrane permeation of cell-penetrating peptides. (2003) (91)
- Partition coefficients in vitro: artificial membranes as a standardized distribution model (1994) (86)
- Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane. (1998) (81)
- Towards the Predictability of Drug-Lipid Membrane Interactions: The pH-Dependent Affinity of Propranolol to Phosphatidylinositol Containing Liposomes (1998) (75)
- Partition behaviour of acids and bases in a phosphatidylcholine liposome–buffer equilibrium dialysis system (1997) (68)
- Permeation of aromatic carboxylic acids across lipid bilayers: the pH-partition hypothesis revisited. (2005) (68)
- Differences in the Intracellular Distribution of Acid-Sensitive Doxorubicin-Protein Conjugates in Comparison to Free and Liposomal Formulated Doxorubicin as Shown by Confocal Microscopy (2004) (67)
- MDCK Cell Cultures as an Epithelial In Vitro Model: Cytoskeleton and Tight Junctions as Indicators for the Definition of Age-Related Stages by Confocal Microscopy (1998) (66)
- ABCC1: a gateway for pharmacological compounds to the ischaemic brain. (2008) (65)
- Role of drug efflux carriers in the healthy and diseased brain (2006) (63)
- A ZO1-GFP fusion protein to study the dynamics of tight junctions in living cells (2002) (63)
- Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells (2005) (55)
- Comparative analysis of the membrane proteome of closely related metastatic and nonmetastatic tumor cells. (2009) (54)
- Comparing the Lipid Membrane Affinity and Permeation of Drug-like Acids: The Intriguing Effects of Cholesterol and Charged Lipids (2007) (52)
- Monitoring of the internalization of neuropeptide Y on neuroblastoma cell line SK-N-MC. (2000) (52)
- Lipoproteins from Borrelia burgdorferi applied in liposomes and presented by dendritic cells induce CD8(+) T-lymphocytes in vitro. (2000) (51)
- Immobilized Artificial Membrane (lAM)-HPLC for Partition Studies of Neutral and Ionized Acids and Bases in Comparison with the Liposomal Partition System (1999) (49)
- P-Glycoprotein in cell cultures: a combined approach to study expression, localisation, and functionality in the confocal microscope. (2000) (47)
- Pharmacokinetic Profiling in Drug Research (2006) (45)
- Lipid‐Bilayer Permeation of Drug‐Like Compounds (2009) (45)
- Cholesterol-mediated activation of P-glycoprotein: distinct effects on basal and drug-induced ATPase activities. (2009) (40)
- Free Fatty Acids Cause pH-Dependent Changes in Drug-Lipid Membrane Interactions Around Physiological pH (1997) (40)
- Formation of Multilayers in the Caco-2 Cell Culture Model: A Confocal Laser Scanning Microscopy Study (2000) (40)
- Assessment of thrombogenic potential of liposomes. (1989) (39)
- Comparison of pharmacokinetic variables for two low-molecular-weight heparins after subcutaneous administration of a single dose to horses. (2002) (32)
- Structure-permeation relations of met-enkephalin peptide analogues on absorption and secretion mechanisms in Caco-2 monolayers. (1997) (32)
- Physicochemical properties in pharmacokinetic lead optimization. (2001) (31)
- Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids (2002) (31)
- The pH-Dependence in the Partitioning Behaviour of (RS)-[3H]Propranolol Between MDCK Cell Lipid Vesicles and Buffer (1996) (30)
- Kinetics of fusion and lipid transfer between virus receptor containing liposomes and influenza viruses as measured with the octadecylrhodamine B chloride assay. (1990) (30)
- P-Glycoprotein in Proteoliposomes with Low Residual Detergent: The Effects of Cholesterol (2007) (27)
- Inactivation of PR8 influenza virus through the octadecylrhodamine B chloride membrane marker. (1993) (20)
- Comparative pharmacokinetic and cytotoxic analysis of three different formulations of mitoxantrone in mice. (1997) (20)
- Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner. (2004) (18)
- Cell-cycle arrest and p53-independent induction of apoptosis in vitro by the new anticancer drugs 5-FdUrd-P-FdCydOct and dCydPam-P-FdUrd in DU-145 human prostate cancer cells (2000) (17)
- Lipid-Bilayer Permeation of Drug-Like Compounds. (2010) (16)
- Induction of cell cycle-dependent cytotoxicity and apoptosis by new heterodinucleoside phosphate dimers of 5-fluorodeoxyuridine in PC-3 human prostate cancer cells. (2000) (16)
- Effect of the virostatic Norakin (triperiden) on influenza virus activities. (1994) (16)
- Dynamics and Cleavability at the alpha-cleavage site of APP(684-726) in different lipid environments. (2008) (14)
- Electron microscopic studies on intracellular phage development--history and perspectives. (1995) (14)
- Interaction kinetics of salmeterol with egg phosphatidylcholine liposomes by surface plasmon resonance. (2009) (13)
- Deconvolution Combined with Digital Colocalization Analysis to Study the Spatial Distribution of Tight and Adherens Junction Proteins (1998) (12)
- Pharmacokinetic studies of mitoxantrone and one of its metabolites in serum and urine in patients with advanced breast cancer (1998) (12)
- Isolated Rafts from Adriamycin-Resistant P388 Cells Contain Functional ATPases and Provide an Easy Test System for P-glycoprotein–Related Activities (2005) (12)
- Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischaemia (2006) (8)
- Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells (1999) (7)
- Liposomes and influenza viruses as an in vitro model for membrane interactions II. Influence of vesicle size and preparation methods (1994) (6)
- Liposomes and influenza viruses as an in vitro model for membrane interactions I. Kinetics of membrane fusion and lipid transfer (1994) (4)
- Methodologies in Cell Culture (2007) (4)
- Permeation Studies In Vitro and In Vivo of Potential Radiopharmaceuticals with Affinity to Neuro Receptors (2000) (4)
- Pharmacokinetics of recombinant hirudin in healthy horses. (2010) (3)
- Temperature-dependent kinetics of the activities of influenza virus. (1990) (2)
- Exploring barrier mechanisms relevant for drug therapy (2004) (1)
- Response to the report by Drexler et al. (2002) (1)
- Pharmacy at the ETH Zürich – Past and Present (2004) (0)
- Influence of trans-fatty acid supplementation on the SAPPα-to-SAPPβ ratio in SH-SY5Y cell cultures (2009) (0)
- In vivo Pharmacokinetic Profiling of Drugs (2007) (0)
- Multidrug resistance-associated protein (MRP)-1: A gateway for drugs to the stroke brain (2008) (0)
- ABCC1: a gateway for drugs to the ischaemic brain (2009) (0)
- From pharmacy to pharmaceutical Sciences: The new curriculum (2004) (0)
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