Heiko Hermeking
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Heiko Hermekingphilosophy Degrees
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Cell Biology
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Molecular Biology
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#1953
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Philosophy Biology
Why Is Heiko Hermeking Influential?
(Suggest an Edit or Addition)Heiko Hermeking's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of c-MYC as a target of the APC pathway. (1998) (4868)
- The miR-34 family in cancer and apoptosis (2010) (1182)
- 14-3-3σ Is a p53-Regulated Inhibitor of G2/M Progression (1997) (1160)
- Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest (2007) (968)
- 14-3-3σ is required to prevent mitotic catastrophe after DNA damage (1999) (878)
- Mediation of c-Myc-induced apoptosis by p53. (1994) (791)
- Analysis of human transcriptomes (1999) (783)
- Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer (2008) (777)
- MicroRNA-34a regulates cardiac ageing and function (2013) (724)
- IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014) (592)
- 14-3-3sigma is a p53-regulated inhibitor of G2/M progression. (1997) (579)
- miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions (2011) (556)
- Identification of CDK4 as a target of c-MYC. (2000) (495)
- MicroRNAs in the p53 network: micromanagement of tumour suppression (2012) (488)
- High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. (2000) (484)
- p53 enters the microRNA world. (2007) (480)
- The 14-3-3 cancer connection (2003) (435)
- Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes (2002) (417)
- Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas (2011) (314)
- Frequent Downregulation of miR-34 Family in Human Ovarian Cancers (2010) (311)
- Functional epigenomics identifies genes frequently silenced in prostate cancer. (2005) (307)
- The p53/miR-34 axis in development and disease. (2014) (295)
- 14-3-3 proteins in cell cycle regulation. (2006) (290)
- 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. (1999) (290)
- Cooperative effects of genes controlling the G(2)/M checkpoint. (2000) (280)
- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop (2011) (232)
- Genome-wide Characterization of miR-34a Induced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis* (2011) (206)
- Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. (1993) (166)
- Human Proteinpedia enables sharing of human protein data (2008) (164)
- p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1 (2016) (164)
- Targeted Proteomic Analysis of 14-3-3ς, a p53 Effector Commonly Silenced in Cancer*S (2005) (157)
- The G2/M Regulator 14-3-3ς Prevents Apoptosis through Sequestration of Bax* (2001) (152)
- SNAIL and miR‐34a feed‐forward regulation of ZNF281/ZBP99 promotes epithelial–mesenchymal transition (2013) (147)
- Large-Scale Identification of c-MYC-Associated Proteins Using a Combined TAP/MudPIT Approach (2007) (144)
- Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and β-Catenin Predicts Distant Metastasis of Colon Cancer (2012) (143)
- AP4 encodes a c-MYC-inducible repressor of p21 (2008) (142)
- Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness (2013) (135)
- AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer (2013) (131)
- The MYC oncogene as a cancer drug target. (2003) (130)
- Wild-type p53 controls cell motility and invasion by dual regulation of MET expression (2011) (129)
- Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis (2012) (119)
- p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. (2014) (107)
- Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells. (2017) (107)
- MicroRNAs as regulators and mediators of c-MYC function. (2015) (100)
- The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization (2005) (100)
- Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1. (1995) (95)
- Characterization of epithelial senescence by serial analysis of gene expression: identification of genes potentially involved in prostate cancer. (2002) (94)
- miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. (2014) (94)
- Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation (2005) (93)
- c-MYC Delays Prometaphase by Direct Transactivation of MAD2 and BubR1: Identification of Mechanisms Underlying c-MYC-Induced DNA Damage and Chromosomal Instability (2007) (91)
- The c-MYC-AP4-p21 cascade (2009) (87)
- Analysis of 14-3-3σ expression in hyperproliferative skin diseases reveals selective loss associated with CpG-methylation in basal cell carcinoma (2003) (86)
- The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. (2001) (82)
- Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. (2002) (80)
- Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis. (2017) (78)
- Prostate cancer is characterized by epigenetic silencing of 14-3-3σ expression (2004) (77)
- The p53/microRNA network in cancer: experimental and bioinformatics approaches. (2013) (72)
- miR-34a and miR-34b/c Suppress Intestinal Tumorigenesis. (2017) (69)
- IL-6 R / STAT 3 / miR-34 a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis (2014) (68)
- The role of epigenetic inactivation of 14-3-3σ in human cancer (2005) (63)
- Epigenetic silencing of 14-3-3sigma in cancer. (2006) (62)
- Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression (2017) (61)
- p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses* (2015) (60)
- DNA Stool Test for Colorectal Cancer: Hypermethylation of the Secreted Frizzled-Related Protein-1 Gene (2007) (58)
- Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations. (2017) (58)
- The p53/microRNA connection in gastrointestinal cancer (2014) (50)
- Prostate cancer is characterized by epigenetic silencing of 14-3-3sigma expression. (2004) (50)
- The role of epigenetic inactivation of 14-3-3sigma in human cancer. (2005) (49)
- Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells (2021) (48)
- Expression, Cellular Distribution, and Prognostic Relevance of TRAIL Receptors in Hepatocellular Carcinoma (2010) (46)
- Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer (2020) (46)
- Characterization of 14-3-3sigma Dimerization Determinants: Requirement of Homodimerization for Inhibition of Cell Proliferation (2006) (45)
- A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation. (1995) (44)
- ZNF281/ZBP-99: a new player in epithelial–mesenchymal transition, stemness, and cancer (2014) (43)
- Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer (2017) (43)
- lnflammation-induced epigenetic switches in cancer (2015) (42)
- Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts. (1994) (41)
- Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2015) (40)
- Consensus-interferon and platelet-derived growth factor adversely regulate proliferation and migration of Kaposi's sarcoma cells by control of c-myc expression. (1996) (39)
- 14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1 (2011) (38)
- Serial analysis of gene expression and cancer (2003) (37)
- Response of human tumour xenografts to fractionated X-irradiation. (1986) (37)
- Loss of p16(INK4a) is associated with reduced patient survival in soft tissue tumours, and indicates a senescence barrier (2014) (36)
- Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc (2004) (35)
- PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer (2018) (34)
- Induction of Cullin 7 by DNA damage attenuates p53 function (2007) (33)
- Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1. (2018) (33)
- The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival (2013) (32)
- AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation (2013) (32)
- p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3 (2015) (30)
- Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer. (2016) (30)
- Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer (2018) (29)
- Digital Karyotyping Reveals Frequent Inactivation of the dystrophin/DMD Gene in Malignant Melanoma (2007) (29)
- Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop (2015) (29)
- 14-3-3 proteins and cancer biology. (2006) (26)
- Inducible microRNA expression by an all-in-one episomal vector system (2006) (25)
- Induction of Apoptosis by the c-Myc Helix-Loop-Helix/Leucine Zipper Domain in Mouse 3T3-L1 Fibroblasts * (1995) (23)
- An interview with Dr. Heiko Hermeking on his highly cited paper published in Cell Cycle (2009) (23)
- ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer (2016) (21)
- Colorectal Cancers Mimic Structural Organization of Normal Colonic Crypts (2014) (21)
- c-MYC and SIRT1 locked in a vicious cycle (2012) (18)
- Viruses as pacemakers in the evolution of defence mechanisms against cancer. (1996) (18)
- Paracrine Induction of Epithelial-Mesenchymal Transition Between Colorectal Cancer Cells and its Suppression by a p53/miR-192/215/NID1 Axis (2019) (18)
- MiR-34a and p53. (2009) (18)
- Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells (2018) (17)
- CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer (2016) (17)
- Microsatellite Instability, KRAS Mutations and Cellular Distribution of TRAIL-Receptors in Early Stage Colorectal Cancer (2012) (16)
- Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis. (2021) (16)
- Imaging hypoxia in diseased tissues. (1997) (15)
- AP4 is required for mitogen- and c-MYC-induced cell cycle progression (2014) (14)
- Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die (2021) (13)
- Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity (2017) (12)
- Extracellular 14-3-3sigma protein: a potential mediator of epithelial-mesenchymal interactions. (2005) (9)
- Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA binding by next-generation sequencing. (2013) (9)
- AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p (2022) (8)
- Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer (2020) (8)
- Identification of microRNA targets by pulsed SILAC. (2014) (8)
- Mir34a constrains pancreatic carcinogenesis (2020) (7)
- Deletion of 14-3-3σ sensitizes mice to DMBA/TPA-induced papillomatosis (2016) (7)
- Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer (2021) (6)
- 1 p 53-regulated networks of protein , mRNA , miRNA and lncRNA expression revealed by integrated p SILAC and NGS analyses (2015) (5)
- Metastasis in Colorectal Cancer Mesenchymal Transition and − Feedback Loop to Regulate Epithelial p 53-Induced miR-15 a / 16-1 and AP 4 Form a Double-Negative (2014) (5)
- 14-3-3σ Functions as an Intestinal Tumor Suppressor (2021) (5)
- AP 4 is required for mitogen-and c-MYC-induced cell cycle progression (2014) (4)
- ZNF281/ZBP-99: a new player in epithelial–mesenchymal transition, stemness, and cancer (2014) (3)
- Monday, 27 August 2012 (2012) (3)
- 14-3-3 sigma regulates B-cell homeostasis through stabilization of FOXO1 [Erratum: Proceedings of the National Academy of Sciences of the United States of America. 2011 Jan;108(4):1555-1560.] (2011) (3)
- Erratum: 14-3-3s regulates B-cell homeostasis through stabilization of FOXO1 (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 4, (1555-1560) DOI: 10.1073/pnas.1017729108) (2011) (3)
- Analysis of the p53/microRNA Network in Cancer. (2022) (1)
- Abstract 12924: Inhibition of microRNA-34a Protects against Aging and Progeria Associated Cardiac Dysfunction by Interfering with Telomere Shortening and DNA Damage Response Pathways (2012) (1)
- Csf1r mediates enhancement of intestinal tumorigenesis caused by inactivation of Mir34a (2022) (1)
- Correction: Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and β-Catenin Predicts Distant Metastasis of Colon Cancer. (2022) (1)
- In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance (2022) (1)
- Membrane vs. cytoplasmatic staining for TRAIL-receptors in colorectal cancer: prognostic significance and therapeutic pitfalls (2012) (0)
- catastrophe after DNA damage (1999) (0)
- Principles of Molecular Oncology (2004) (0)
- Use of Mircoinjection to Study Apoptosis and its Prevention (1999) (0)
- The G(2)/M regulator 14-3-3 sigma prevents the progression of apoptosis by associating with Bax (2001) (0)
- Cancer Drug Target Identification by SAGE, LongSAGE and Digital Karyotyping (2005) (0)
- Imaging , Diagnosis , Prognosis Detection of miR-34 a Promoter Methylation in Combination with Elevated Expression of c-Met and b-Catenin Predicts Distant Metastasis of Colon Cancer (2013) (0)
- AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p (2022) (0)
- The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution (2005) (0)
- What is left in the 'post-genome' era? (2001) (0)
- lnflammation-induced epigenetic switches in cancer (2015) (0)
- Loss of 14-3-3S expression in basal cell carcinoma by epigenetic si-lencing via CPG-methylation (2004) (0)
- Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells (2018) (0)
- Meta-analysis of miR-34 target mRNAs using an integrative online application (2022) (0)
- Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer (2020) (0)
- Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer (2017) (0)
- Genome-wide analysis of epigenetically silenced genes in prostate cancer (2004) (0)
- Genome-Wide Analysis of c-MYC-Regulated mRNAs and miRNAs and c-MYC DNA-Binding by Next-Generation Sequencing. (2021) (0)
- CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota. (2022) (0)
- c-MYC-Induced AP4 Attenuates DREAM-Mediated Repression by p53 (2023) (0)
- SMAD4 Loss Induces c-MYC–Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis (2022) (0)
- Clinical Cancer esearch ing , Diagnosis , Prognosis ression , Cellular Distribution , and Prognostic Relevance R RAIL Receptors in Hepatocellular Carcinoma (2010) (0)
- miR-34a and IRE1A/XBP-1(S) Form a Double-Negative Feedback Loop to Regulate Hypoxia-Induced EMT, Metastasis, Chemo-Resistance and Autophagy (2023) (0)
- Erratum: Wagner, A.E., et al. SP8 Promotes an Aggressive Phenotype in Hepatoblastoma via FGF8 Activation. Cancers 2020, 12, 2294 (2021) (0)
- Review The p 53 / miR- 34 axis in development and disease (2014) (0)
- CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota. (2022) (0)
- Loss of 14-3-3s expression in basal cell carcinoma by epigenetic silencing via CpG-methylation 1 1 Disclosure not available at press time. (2004) (0)
- MicroRNA-34a is a pivotal age-induced regulator of cardiac apoptosis, telomere maintenance and contractile function: Implications for therapeutic inhibition (2012) (0)
- Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression (2017) (0)
- Amendment history : Corrigendum ( March 2015 ) IL-6 R / STAT 3 / miR-34 a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis (2018) (0)
- Interferon-con1 inhibitsc-myc gene expression in kaposi’s sarcoma cells (2007) (0)
- Wnt/LARGE2/α-DG axis reveals possible target for colorectal cancer therapy (2020) (0)
- TGFβ1 regulation of cdc2 transcription involves the E1A associated protein p130 (1994) (0)
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What Schools Are Affiliated With Heiko Hermeking?
Heiko Hermeking is affiliated with the following schools:
