Helen Blackwell
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American chemist and molecular biologist
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Helen Blackwellbiology Degrees
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Chemistry Biology
Helen Blackwell's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Helen Blackwell Influential?
(Suggest an Edit or Addition)According to Wikipedia, Helen E. Blackwell is an American organic chemist and chemical biologist. She is a professor at the University of Wisconsin–Madison. Education Blackwell is a native of Shaker Heights, Ohio and was educated as an undergraduate at Oberlin College, receiving a Bachelor of Arts degree in chemistry in 1994. She received a Ph.D. in organic chemistry from the California Institute of Technology in 1999 working with Robert Grubbs.
Helen Blackwell's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening* (2001) (516)
- Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis. (1998) (397)
- Small molecule inhibitors of bacterial quorum sensing and biofilm formation. (2005) (285)
- New Approaches to Olefin Cross-Metathesis (2000) (264)
- Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function. (2009) (230)
- Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. (2007) (212)
- Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria. (2008) (200)
- Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides. (2001) (190)
- SIR1, an Upstream Component in Auxin Signaling Identified by Chemical Genetics (2003) (178)
- Local and tunable n-->pi* interactions regulate amide isomerism in the peptoid backbone. (2007) (161)
- New strategies for the design of folded peptoids revealed by a survey of noncovalent interactions in model systems. (2009) (159)
- Extraordinarily robust polyproline type I peptoid helices generated via the incorporation of α-chiral aromatic N-1-naphthylethyl side chains. (2011) (154)
- Small molecule disruption of quorum sensing cross-regulation in pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes. (2015) (132)
- Chemical Genetic Approaches to Plant Biology1 (2003) (131)
- 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms. (2012) (127)
- Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. (2002) (123)
- Self-assembly of taper-shaped monoesters of oligo(ethylene oxide) with 3,4,5-tris(n-dodecan-1-yloxy)benzoic acid and of their polymethacrylates into tubular supramolecular architectures displaying a columnar hexagonal mesophase (1993) (116)
- Slippery Liquid‐Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non‐Adherent Pathogens in Surrounding Media: A Controlled Release Approach (2016) (115)
- New and unexpected insights into the modulation of LuxR-type quorum sensing by cyclic dipeptides. (2009) (107)
- Small molecules that modulate quorum sensing and control virulence in Pseudomonas aeruginosa. (2010) (104)
- Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum (2011) (101)
- Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones. (2012) (101)
- Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide. (2013) (100)
- Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria (2014) (98)
- Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up. (2003) (98)
- Chemical probes of quorum sensing: from compound development to biological discovery. (2016) (96)
- Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. (2008) (88)
- A peptoid ribbon secondary structure. (2013) (88)
- Plant Responses to Bacterial N-Acyl l-Homoserine Lactones are Dependent on Enzymatic Degradation to l-Homoserine (2014) (84)
- N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in Vibrio fischeri. (2007) (84)
- A one-bead, one-stock solution approach to chemical genetics: part 1. (2001) (83)
- Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump (2007) (83)
- Thiolactone modulators of quorum sensing revealed through library design and screening. (2011) (82)
- Comparative Analyses of N‐Acylated Homoserine Lactones Reveal Unique Structural Features that Dictate Their Ability to Activate or Inhibit Quorum Sensing (2008) (81)
- Construction of peptoids with all trans-amide backbones and peptoid reverse turns via the tactical incorporation of N-aryl side chains capable of hydrogen bonding. (2010) (79)
- A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design (2015) (76)
- Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis. (2006) (74)
- Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa. (2016) (72)
- Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus. (2008) (72)
- Tuning peptoid secondary structure with pentafluoroaromatic functionality: a new design paradigm for the construction of discretely folded peptoid structures. (2006) (71)
- Chemical modification of reactive multilayered films fabricated from poly(2-alkenyl azlactone)s: design of surfaces that prevent or promote mammalian cell adhesion and bacterial biofilm growth. (2009) (71)
- Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells. (2016) (67)
- Expedient synthesis and design strategies for new peptoid construction. (2005) (65)
- Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. (2008) (60)
- Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening (2010) (60)
- Re-entrant isotropic phase in a supramolecular disc-like oligomer of 4-[3,4,5-tris(n-dodecanyloxy)benzoyloxy]-4′-[(2-vinyloxy)ethoxy]biphenyl (1992) (60)
- Microwave-accelerated SPOT-synthesis on cellulose supports. (2004) (55)
- Active Efflux Influences the Potency of Quorum Sensing Inhibitors in Pseudomonas aeruginosa (2014) (52)
- Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second‐Generation Libraries of N‐Acylated L‐Homoserine Lactones (2011) (52)
- Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators. (2013) (51)
- Discovery of fluorescent cyanopyridine and deazalumazine dyes using small molecule macroarrays. (2006) (50)
- Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus. (2016) (49)
- Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non‐native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa (2015) (47)
- Identification of Unanticipated and Novel N-Acyl L-Homoserine Lactones (AHLs) Using a Sensitive Non-Targeted LC-MS/MS Method (2016) (45)
- Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing. (2011) (45)
- Design and conformational analysis of peptoids containing N-hydroxy amides reveals a unique sheet-like secondary structure. (2011) (44)
- Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts. (2011) (42)
- Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation. (2016) (42)
- Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus. (2013) (40)
- Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by nonlactone ligands. (2014) (39)
- Periprosthetic bacterial biofilm and quorum sensing (2018) (38)
- Synthesis and characterization of nitroaromatic peptoids: fine tuning peptoid secondary structure through monomer position and functionality. (2009) (38)
- Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays. (2009) (38)
- Introduction to bacterial signals and chemical communication. (2011) (38)
- Small molecule macroarray construction via Ugi four-component reactions. (2005) (37)
- Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus (2015) (37)
- Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. (2018) (35)
- Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports. (2006) (33)
- Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: small molecules with great potential. (2007) (32)
- Simplified AIP‐II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors (2017) (31)
- Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus. (2016) (31)
- Exploiting site-site interactions on solid support to generate dimeric molecules. (2001) (29)
- Synthesis of the 17-electron cations [FeL(L′)(NO)2]+(L, L′= PPh3, OPPh3): structure and bonding in four-co-ordinate metal dinitrosyls, and implications for the identity of paramagnetic iron dinitrosyl complex catalysts (1996) (28)
- Surface Coatings that Promote Rapid Release of Peptide‐Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus (2014) (28)
- N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus. (2014) (28)
- Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor (2015) (28)
- Chemical methods to interrogate bacterial quorum sensing pathways. (2012) (28)
- Structure-Function Analyses of the N-Butanoyl l-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR. (2018) (27)
- Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics. (2006) (26)
- Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods (2006) (26)
- Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non‐native ligands (2018) (26)
- Quorum Sensing in Bacterial Species that Use Degenerate Autoinducers Can Be Tuned by Using Structurally Identical Non‐native Ligands (2011) (25)
- Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control. (2017) (25)
- Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity. (2011) (24)
- Efficient construction of diketopiperazine macroarrays through a cyclative-cleavage strategy and their evaluation as luminescence inhibitors in the bacterial symbiont Vibrio fischeri. (2009) (24)
- A New Model for Transitioning Students from the Undergraduate Teaching Laboratory to the Research Laboratory. The Evolution of an Intermediate Organic Synthesis Laboratory Course (2006) (23)
- Quorum-sensing signals in the microbial community of the cabbage white butterfly larval midgut (2008) (23)
- Terminal olefin cross-metathesis with acrolein acetals (1999) (23)
- Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling. (2017) (22)
- Design, synthesis, and biochemical characterization of non-native antagonists of the Pseudomonas aeruginosa quorum sensing receptor LasR with nanomolar IC50 values. (2020) (21)
- Surface‐Mediated Release of a Small‐Molecule Modulator of Bacterial Biofilm Formation: A Non‐Bactericidal Approach to Inhibiting Biofilm Formation in Pseudomonas aeruginosa (2013) (21)
- Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor. (2019) (17)
- Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR. (2015) (17)
- N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa. (2019) (16)
- Liquid Crystal Emulsions that Intercept and Report on Bacterial Quorum Sensing. (2020) (15)
- N-Acyl homoserine lactone analog modulators of the Pseudomonas aeruginosa RhlI quorum sensing signal synthase. (2019) (15)
- Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads (2001) (15)
- Non-native acylated homoserine lactones reveal that LuxIR quorum sensing promotes symbiont stability. (2014) (13)
- Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume–Rhizobia Symbiosis (2016) (13)
- A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence. (2018) (12)
- Deciphering a protolanguage for bacteria-host communication. (2008) (12)
- Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides. (1997) (12)
- Rapid identification of antibacterial agents effective against Staphylococcus aureus using small-molecule macroarrays. (2007) (12)
- Non‐native N‐Aroyl L‐Homoserine Lactones Are Potent Modulators of the Quorum Sensing Receptor RpaR in Rhodopseudomonas palustris (2014) (11)
- Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor in Salmonella enterica serovar Typhimurium (2018) (10)
- Small molecule macroarray construction via palladium-mediated carbon-carbon bond-forming reactions: highly efficient synthesis and screening of stilbene arrays. (2010) (10)
- Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors. (2011) (9)
- Diversity‐Oriented Synthesis of Biaryl‐Containing Medium Rings Using a One Bead/One Stock Solution Platform. (2002) (9)
- Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor. (2020) (9)
- Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids. (2017) (9)
- Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis (2019) (8)
- Bacterial crowd control with iron. (2005) (8)
- Bacterial Quorum Sensing Signals Self-Assemble in Aqueous Media to Form Micelles and Vesicles: An Integrated Experimental and Molecular Dynamics Study. (2020) (8)
- Improved small-molecule macroarray platform for the rapid synthesis and discovery of antibacterial chalcones. (2011) (8)
- Bacterial Quorum Sensing Signals Promote Large-Scale Remodeling of Lipid Membranes. (2021) (7)
- Chemical Methods to Interrogate Bacterial Quorum Sensing Pathways (2013) (6)
- Selection of Appropriate Autoinducer Analogues for the Modulation of Quorum Sensing at the Host-Bacterium Interface. (2018) (6)
- Design, synthesis, and biochemical characterization of non-native antagonists of the Pseudomonas aeruginosa quorum sensing receptor LasR with nanomolar IC 50 values (2020) (6)
- Conformational Switch to a β-turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency. (2019) (6)
- Potent modulation of the CepR quorum sensing receptor and virulence in a Burkholderia cepacia complex member using non-native lactone ligands (2019) (5)
- Fabrication of Slippery Liquid-Infused Coatings in Flexible Narrow-Bore Tubing. (2021) (5)
- Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing. (2012) (5)
- Non-Native Peptides Capable of Pan-Activating the agr Quorum Sensing System across Multiple Specificity Groups of Staphylococcus epidermidis. (2021) (5)
- A New Method for Cross-Metathesis of Terminal Olefins. (1998) (4)
- New Approaches to Olefin Cross-Metathesis. (2000) (4)
- The role of the specialist nurse in pelvic floor dysfunction. (2003) (3)
- Self‐Assembly of Taper‐Shaped Monoesters of Oligo(ethylene Oxide) with 3,4,5‐Tris(n‐dodecan‐1‐yloxy)benzoic Acid and of Their Polymethacrylates into Tubular Supramolecular Architectures Displaying a Columnar Hexagonal Mesophase. (1994) (3)
- Liquid Crystal-Infused Porous Polymer Surfaces: A "Slippery" Soft Material Platform for the Naked-Eye Detection and Discrimination of Amphiphilic Species. (2021) (3)
- Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay (2021) (3)
- Corrigendum: Active Efflux Influences the Potency of Quorum Sensing Inhibitors in Pseudomonas aeruginosa (2014) (2)
- Terminal Olefin Cross-Metathesis with Acrolein Acetals. (1999) (2)
- Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo. (2022) (2)
- Slippery Antifouling Polymer Coatings Fabricated Entirely from Biodegradable and Biocompatible Components. (2022) (2)
- Interactions of Bacterial Quorum Sensing Signals with Model Lipid Membranes: Influence of Acyl Tail Structure on Multiscale Response. (2021) (2)
- A stoma care nurse specialist. (2015) (2)
- Helping people who self-harm. (2008) (2)
- Novel methods for cross-metathesis of terminal olefins (1998) (1)
- SYNTHESIS OF THE 17-ELECTRON CATIONS FEL(L')(NO2+ (L,L' = PPH3, OPPH3) : STRUCTURE AND BONDING IN FOUR-CO-ORDINATE METAL DINITROSYLS, AND IMPLICATIONS FOR THE IDENTITY OF PARAMAGNETIC FOR THE IDENTITY OF PARAMAGNETIC FOR THE IDENTIFY OF PARAMAGNETIC IRON DINITROSYL COMPLEX CATALYSTS (1996) (1)
- Correction to Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones (2011) (1)
- Expanding Dialogues: From Natural Autoinducers to Non‐Natural Analogues that Modulate Quorum Sensing in Gram‐Negative Bacteria (2008) (1)
- Rapid Synthesis of Diketopiperazine Macroarrays (2006) (1)
- Crisis Resolution and Home Treatment in Mental Health: Mixed blessings: service user experience of crisis teams (2008) (1)
- Healing the wounds. (2007) (1)
- Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut (2023) (1)
- Small Molecules with Either Receptor-Selective or Pan-Receptor Activity in the Three LuxR-Type Receptors that Regulate Quorum Sensing in Pseudomonas aeruginosa. (2022) (1)
- Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump (cid:1) (2007) (1)
- N‐{(Aminocarbonyl)[(S)‐4‐nitrobenzyl]methyl}‐N‐{[(R)‐cyclohexyl](cyclohexylaminocarbonyl)methyl}propanamide methanol solvate (2007) (1)
- luorination of Alkyl Aryl Thioethers with Halonium Electrophiles in the Presence of Fluorinating Reagents and Its Application for 18F-Radiolabeling (2010) (0)
- Author Correction: Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut (2023) (0)
- Interception of Quorum Sensing in Staphylococcus aureus: A New Niche for Peptidomimetics (2006) (0)
- Identification of Synthetic Inducers and Inhibitors of the 3 Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa 4 by High-Throughput Screening 5 6 7 8 (2010) (0)
- Out of the Oil Bath and into the Oven — Microwave‐Assisted Combinatorial Chemistry Heats up. (2003) (0)
- Synthetic Ligands that Disrupt Bacterial Quorum Sensing Pathways and Outcomes (2008) (0)
- New synthetic applications for ring-closing metathesis and cross-metathesis employing well-defined ruthenium alkylidenes (1999) (0)
- Chemical and biomolecular insights into the Staphylococcus aureus agr quorum sensing system: Current progress and ongoing challenges (2023) (0)
- The state of the union is strong : A review of ASM ’ s 6 th conference on Cell-cell Communication 1 in Bacteria 2 3 4 5 6 (2018) (0)
- Ring‐Closing Metathesis of Olefinic Peptides: Design, Synthesis, and Structural Characterization of Macrocyclic Helical Peptides. (2001) (0)
- Slippery nanoemulsion-infused porous surfaces (SNIPS): anti-fouling coatings that can host and sustain the release of water-soluble agents. (2021) (0)
- Strong Loyola Grid Team To Play Institute (0)
- Oral History Interview: Helen Blackwell (0867) (2007) (0)
- Expanding the Language of Bacterial Quorum Sensing Using Synthetic Lligands (2015) (0)
- Towards a pan‐group activator of the quorum sensing system in the common pathogen Staphylococcus epidermidis (2018) (0)
- Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics. (2022) (0)
- CORRIGENDUM (1998) (0)
- The State of the Union Is Strong: a Review of ASM's 6th Conference on Cell-Cell Communication in Bacteria (2018) (0)
- Systems genetics uncovers microbe-lipid-host connections in the murine gut (2021) (0)
- Correction to "N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa". (2020) (0)
- N-[1-(Pentafluorophenyl)ethyl]acetamide. (2006) (0)
- S-27-5 Distribution and regulation of imidazoline receptors in the brain (1996) (0)
- Self-assembly of bacterial quorum sensing signals in aqueous media: Integrated experimental and molecular dynamics study (2020) (0)
- Interactions of Bacterial Quorum Sensing Signals with Model Lipid Membranes: Influence of Membrane Composition on Membrane Remodeling. (2022) (0)
- Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells (2022) (0)
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