Helen Danesh-Meyer | Academic Influence

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Helen Danesh-Meyer

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Helen Danesh-Meyer

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Helen Danesh-Meyer's Degrees

Masters Medicine University of Auckland
PhD Ophthalmology University of Auckland

Why Is Helen Danesh-Meyer Influential?

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According to Wikipedia, Helen Victoria Danesh-Meyer is a New Zealand ophthalmology academic, and as of 2018 is a full professor at the University of Auckland. Academic career After an undergraduate at the University of Otago followed by a 2004 MD titled 'The evaluation of diagnostic procedures, visual outcome and optic nerve morphology in giant cell arteritis' and a 2013 PhD titled 'Evaluation of optic nerve morphology in non-glaucomatous optic neuropathies with quantitative optic nerve imaging modalities' at the University of Auckland, Danesh-Meyer joined the staff at Auckland, rising to full professor.

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Helen Danesh-Meyer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Locally Administered Ocular Corticosteroids (2002) (195)
In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors. (2008) (184)
Radiation-induced optic neuropathy (2008) (174)
Poor prognosis of visual outcome after visual loss from giant cell arteritis. (2005) (172)
Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia. (2012) (166)
Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging (2006) (160)
Relationship between retinal nerve fiber layer and visual field sensitivity as measured by optical coherence tomography in chiasmal compression. (2006) (142)
Case reports and small case series: ocular and cerebral ischemia following facial injection of autologous fat. (2001) (130)
Neuroprotection in glaucoma: recent and future directions (2011) (123)
The prevalence of cupping in end-stage arteritic and nonarteritic anterior ischemic optic neuropathy. (2001) (121)
Non-arteritic anterior ischaemic optic neuropathy: A review and update (2009) (117)
Recovery of visual function in patients with biopsy-proven giant cell arteritis. (2003) (117)
Optical coherence tomography predicts visual outcome for pituitary tumors (2015) (116)
Occurrence of cerebral venous sinus thrombosis in patients with presumed idiopathic intracranial hypertension. (2006) (107)
Low Diagnostic Yield With Second Biopsies in Suspected Giant Cell Arteritis (2000) (100)
Comparison of intraocular pressure measured by Pascal dynamic contour tonometry and Goldmann applanation tonometry (2006) (93)
Role of connexin43 in central nervous system injury (2010) (93)
Thrombocytosis in patients with biopsy-proven giant cell arteritis. (2002) (89)
Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers (2014) (86)
The ice test versus the rest test in myasthenia gravis. (2000) (84)
Glaucoma and the brain: Trans-synaptic degeneration, structural change, and implications for neuroprotection. (2017) (81)
Hypothesis: a venous etiology for nonarteritic anterior ischemic optic neuropathy. (2008) (80)
Neuroprotection: extrapolating from neurologic diseases to the eye. (2009) (78)
Connexin43 in retinal injury and disease (2016) (77)
Optic disc morphology in open-angle glaucoma compared with anterior ischemic optic neuropathies. (2010) (73)
Diagnostic accuracy of confrontation visual field tests (2010) (72)
Comparison of disc damage likelihood scale, cup to disc ratio, and Heidelberg retina tomograph in the diagnosis of glaucoma (2006) (71)
Visual acuity and pattern of visual field loss at presentation in pituitary adenoma (2014) (70)
Diagnosis and management of optic nerve glioma (2011) (68)
A key role for connexin hemichannels in spreading ischemic brain injury. (2012) (67)
Visual outcomes and headache following interventions for idiopathic intracranial hypertension (2014) (63)
Immunolocalization of gap junction protein connexin43 (GJA1) in the human retina and optic nerve. (2010) (63)
Intraocular pressure changes after treatment for Graves' orbitopathy. (2001) (60)
Comparison of arteritis and nonarteritic anterior ischemic optic neuropathies with the Heidelberg Retina Tomograph. (2005) (60)
Diagnosis and management of optic nerve sheath meningiomas (2013) (59)
Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression (2015) (58)
Connexin43 antisense oligodeoxynucleotide treatment down-regulates the inflammatory response in an in vitro interphase organotypic culture model of optic nerve ischaemia (2008) (57)
Bilateral angle closure glaucoma induced by sulphonamide‐derived medications (2007) (57)
Sustained intravitreal delivery of connexin43 mimetic peptide by poly(D,L-lactide-co-glycolide) acid micro- and nanoparticles--Closing the gap in retinal ischaemia. (2015) (56)
Phosphodiesterase inhibitors and the eye (2009) (50)
Regional correlation of structure and function in glaucoma, using the Disc Damage Likelihood Scale, Heidelberg Retina Tomograph, and visual fields. (2006) (49)
A 1-Year Study to Compare the Efficacy and Safety of Once-Daily Travoprost 0.004%/Timolol 0.5% to Once-Daily Latanoprost 0.005%/Timolol 0.5% in Patients with Open-Angle Glaucoma or Ocular Hypertension (2007) (45)
Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels (2017) (44)
Lost in translation: bumps in the road between bench and bedside. (2010) (43)
Posterior ischemic optic neuropathy after hemodialysis. (2003) (43)
Optic disc evaluation in optic neuropathies: the optic disc assessment project. (2011) (43)
Ophthalmic manifestations of inherited neurodegenerative disorders (2014) (41)
Connexin43 Mimetic Peptide Improves Retinal Function and Reduces Inflammation in a Light-Damaged Albino Rat Model. (2016) (41)
Corneal nerve microstructure in Parkinson’s disease (2017) (40)
Macular thickness predictive of visual field sensitivity in ischaemic optic neuropathy (2012) (40)
High pressure-induced retinal ischaemia reperfusion causes upregulation of gap junction protein connexin43 prior to retinal ganglion cell loss (2012) (40)
Incidence and management of cataract after glaucoma surgery (2013) (40)
What do people with glaucoma know about their condition? A comparative cross‐sectional incidence and prevalence survey (2008) (39)
Agreement between stereoscopic photographs, clinical assessment, Heidelberg retina tomograph and digital stereoscopic optic disc camera in estimating verticalcup:disc ratio (2005) (38)
Correlation of retinal nerve fiber layer measured by scanning laser polarimeter to visual field in ischemic optic neuropathy. (2006) (38)
Statins can induce myasthenia gravis (2014) (36)
Erectile dysfunction drugs and risk of anterior ischaemic optic neuropathy: casual or causal association? (2007) (34)
Visual loss and recovery in chiasmal compression (2019) (34)
Probabilistic MRI Tractography of the Optic Radiation Using Constrained Spherical Deconvolution: A Feasibility Study (2015) (33)
Glaucoma as a Neurodegenerative Disease (2015) (33)
Visual loss despite anticoagulation in radiation‐induced optic neuropathy (2004) (33)
Gap junction protein connexin43 (GJA1) in the human glaucomatous optic nerve head and retina (2011) (33)
Differentiation of compressive from glaucomatous optic neuropathy with spectral-domain optical coherence tomography. (2014) (32)
Exploring topical anti-glaucoma medication effects on the ocular surface in the context of the current understanding of dry eye. (2018) (32)
Giant cell arteritis (2009) (32)
Intravitreal pro-inflammatory cytokines in non-obese diabetic mice: Modelling signs of diabetic retinopathy (2018) (32)
Risk factors for first presentation of glaucoma with significant visual field loss (2008) (32)
The water‐drinking test: the elegance of simplicity (2008) (32)
Differences in practice and personal profiles between male and female ophthalmologists (2007) (31)
The correlation of phenylephrine 1% with hydroxyamphetamine 1% in Horner’s syndrome (2004) (31)
Understanding the mechanism of the water drinking test: the role of fluid challenge volume in patients with medically controlled primary open angle glaucoma (2010) (31)
Medically controlled glaucoma patients show greater increase in intraocular pressure than surgically controlled patients with the water drinking test. (2008) (30)
Not so slowly progressive visual loss. (1999) (29)
Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease (2018) (29)
New developments in giant cell arteritis. (2016) (29)
Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia (2015) (28)
Shrinkage: fact or fiction? (2001) (28)
Neuroprotection in the treatment of glaucoma--A focus on connexin43 gap junction channel blockers. (2015) (27)
Glaucoma prescribing trends in Australia and New Zealand (2006) (27)
Correlation of the multifocal visual evoked potential and standard automated perimetry in compressive optic neuropathies. (2006) (26)
Connexin hemichannel induced vascular leak suggests a new paradigm for cancer therapy (2014) (25)
COVID-19 Vaccination and The Eye (2022) (24)
Giant cell arteritis (2000) (24)
Giant cell arteritis (2006) (24)
The optic nerve head in hereditary optic neuropathies (2009) (23)
Screening glaucoma genes in adult glaucoma suggests a multiallelic contribution of CYP1B1 to open‐angle glaucoma phenotypes (2012) (23)
Gap junction proteins in the light-damaged albino rat (2014) (23)
Patient satisfaction with topical ocular hypotensives (2013) (23)
Retinal nerve fiber layer loss in glaucoma patients with a relative afferent pupillary defect. (2010) (22)
Cytotoxicity and vitreous stability of chemically modified connexin43 mimetic peptides for the treatment of optic neuropathy. (2013) (22)
Multifocal malignant optic glioma of adulthood presenting as acute anterior optic neuropathy (2011) (22)
Comparison of the Proview pressure phosphene tonometer performed by the patient and examiner with the Goldmann applanation tonometer (2004) (21)
Gaze-evoked amaurosis produced by intraorbital buckshot pellet. (2001) (21)
Functional effects of unilateral open-angle glaucoma on the primary and extrastriate visual cortex. (2015) (20)
Implications of COVID-19 for Ophthalmologists (2020) (20)
Assessment of Optic Pathway Structure and Function in Patients With Compression of the Optic Chiasm: A Correlation With Optical Coherence Tomography. (2016) (20)
Connexin43 Modulation Inhibits Scarring in a Rabbit Eye Glaucoma Trabeculectomy Model (2012) (19)
Acute primary angle closure attack does not cause an increased cup-to-disc ratio. (2011) (19)
Caffeine and the eye. (2019) (19)
Temporal artery biopsy: skip it at your patient's peril. (2012) (18)
Optic nerve atrophy in adrenoleukodystrophy detectable by optic coherence tomography (2010) (18)
Uveitis screening: HLAB27 antigen and ankylosing spondylitis in a New Zealand population. (2006) (17)
Anxiety in visual field testing (2015) (17)
Response of retinal Connexin43 to optic nerve injury. (2011) (17)
Cosmetically significant proptosis following a tube shunt procedure. (2002) (16)
Prognostic utility of optical coherence tomography for long-term visual recovery following pituitary tumor surgery. (2020) (16)
The optic nerve head in acquired optic neuropathies (2010) (16)
Glaucoma management trends in Australia and New Zealand (2006) (16)
Focus on molecules: connexin 43--mind the gap. (2008) (16)
Orbital compartment syndrome following aneurysm surgery (2012) (15)
Visual loss in pregnancy. (2000) (14)
Microdroplet and spatter contamination during phacoemulsification cataract surgery in the era of COVID‐19 (2020) (14)
Autoimmune retinopathy associated with carcinoid tumour of the small bowel (2014) (13)
Epiretinal membrane: a treatable cause of visual disability in myotonic dystrophy type 1 (2013) (13)
Evaluation of an algorithm for detecting visual field defects due to chiasmal and postchiasmal lesions: the neurological hemifield test. (2011) (12)
SURGICAL UNDERTREATMENT OF GLAUCOMA IN BLACK BENEFICIARIES OF MEDICARE (2000) (12)
Management of acute optic neuritis: A survey of neurologists and ophthalmologists in Australia and New Zealand (2008) (12)
Herpes zoster ophthalmicus clinical presentation and risk factors for loss of vision. (2021) (12)
Gender differences in Australasian ophthalmologists' experiences of the workplace (2019) (12)
Cannabinoids and the eye. (2020) (12)
Ahhh, that's a strange eye movement. (2002) (12)
An eye on gender equality: A review of the evolving role and representation of women in ophthalmology. (2021) (11)
Connexin-based therapeutic approaches to inflammation in the central nervous system (2013) (10)
Giant cell arteritis: managing the ophthalmic medical emergency (2003) (10)
Brightness sensitivity and color perception as predictors of relative afferent pupillary defect. (2007) (10)
Optical coherence tomography findings in a patient with type 1 sialidosis (2016) (10)
Suprasellar meningioma presenting with an altitudinal field defect (2012) (9)
Imaging of the optic nerve: technological advances and future prospects (2022) (9)
Gender differences in surgical case volume among ophthalmology trainees (2021) (9)
Visual symptoms in the presentation of Creutzfeldt–Jakob disease (2015) (9)
Neovascular glaucoma and sarcoidosis (2005) (9)
Symptomatic intracranial hypertension during recovery from the syndrome of headache with neurologic deficits and cerebrospinal fluid lymphocytosis (HANDL) (2017) (9)
The role of retinal nerve fiber layer in predicting recovery of vision following surgery for pituitary adenomas. (2009) (9)
Unilateral lid retraction during pregnancy. (2000) (8)
Idiopathic intracranial hypertension: Pathophysiology, diagnosis and management (2022) (8)
Temporal patterns of visual recovery following pituitary tumor resection: A prospective cohort study (2021) (8)
A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine (2021) (7)
Neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein IgG associated disorder: A comprehensive neuro‐ophthalmic review (2021) (7)
Neuro-Ophthalmic Manifestations of HIV Infection (2020) (7)
Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma (2015) (7)
Large-Spot Subthreshold Infrared Laser to Treat Diabetic Macular Edema (2008) (7)
Intraocular pressure fluctuation during resistance exercise (2021) (6)
Friederich Nietzsche and the seduction of Occam’s razor (2010) (5)
Bullying and harassment in ophthalmology: a trainee survey. (2020) (5)
Diagnosing pre-clinical dementia: the NZ Genetic Frontotemporal Dementia Study (FTDGeNZ). (2018) (5)
At the crossroads of glaucoma and neuro-ophthalmology. (2015) (5)
Ophthalmic findings in myotonic dystrophy type 2: a case series (2016) (5)
Comprar Neuro-Ophthalmology. Color Atlas & Synopsis Of Clinical Ophthalmology. Wills Eye Institute + Online Access 2nd Ed. | Peter Savino | 9781609132668 | Lippincott Williams & Wilkins (2012) (5)
Aggressive glioma of adulthood simulating ischemic optic neuropathy. (2005) (4)
Glaucoma Drainage Device Technique in a Cohort of Experienced Glaucoma Surgeons in Australia and New Zealand (2020) (4)
Acute bilateral ophthalmoplegia in a young woman. (2000) (3)
Jaw Dropping: The Necessity of a History and a Biopsy in Suspected Temporal Arteritis (2011) (3)
11 – Neuro-ophthalmology of brain tumors (2012) (3)
Orbital Inflammatory Disease (2007) (3)
A Venous Etiology for Nonarteritic Anterior Ischemic Optic Neuropathy (2017) (3)
Two cases of episcleral tattooing presenting to the acute ophthalmic clinic. (2020) (3)
A comparison of macular ganglion cell and retinal nerve fibre layer optical coherence tomographic parameters as predictors of visual outcomes of surgery for pituitary tumours (2022) (3)
Intraocular pressure: relevant or redundant? (2005) (3)
Bullying, harassment and sexual discrimination among ophthalmologists in Australia and New Zealand (2020) (3)
Effect on intraocular pressure of extraocular muscle surgery for thyroid-associated ophthalmopathy. (2008) (2)
Measuring visual field loss in glaucoma using involuntary eye movements (2019) (2)
Combination brimonidine and timolol. (2010) (2)
Withdrawal from a Donor Insemination Programme (1993) (2)
Variations in optic nerve head morphology by intraocular pressure in open-angle glaucoma (2017) (2)
Stroke risk after ocular cranial nerve palsy – A systematic review and meta-analysis (2022) (2)
Progressive visual loss and ophthalmoplegia. (2000) (2)
Diagnostic performance of neuroimaging in suspected idiopathic intracranial hypertension (2021) (2)
Efficient capture of high-quality real-world data on treatments for glaucoma: the Fight Glaucoma Blindness! Registry (2021) (2)
Transiently Raised IOP Equivalent To That Experienced During Ocular Surgery Causes Moderate Inflammation But Does Not Affect Retinal Function Or Result in Retinal Ganglion Cell Loss in An Animal Model (2017) (2)
Long term outcomes of idiopathic intracranial hypertension: Observational study and literature review (2021) (2)
Unilateral acquired upper eyelid ptosis and decreasing nystagmus. (2002) (1)
Retina Connexin 43 Mimetic Peptide Improves Retinal Function and Reduces Inflammation in a Light-Damaged Albino Rat Model (2016) (1)
Presumed autoimmune retinopathy following chickenpox; a case report (2018) (1)
Eye Movements in Mild Traumatic Brain Injury: Clinical Challenges (2022) (1)
D7 Optical coherence tomography findings in huntington’s disease: a potential biomarker of disease progression (2016) (1)
Gender differences in income. (2008) (1)
Eye Movement Abnormalities in Glaucoma Patients: A Review (2022) (1)
Ethylenediaminetetraacetic Acid Chelation in Herpes Zoster Ophthalmicus Is Associated With a High Rate of Corneal Melt and Perforation. (2020) (1)
Current practice of trabeculectomy in a cohort of experienced glaucoma surgeons in Australia and New Zealand (2022) (1)
Current practice of trabeculectomy in a cohort of experienced glaucoma surgeons in Australia and New Zealand (2022) (1)
Prompt antiviral therapy is associated with lower risk of cerebrovascular accident following herpes zoster ophthalmicus. (2022) (1)
Association of Nailfold Capillary Abnormalities With Primary Open-angle Glaucoma and Glaucomatous Visual Field Loss (2020) (1)
Neurotrophic Keratopathy After Herpes Zoster Ophthalmicus (2022) (1)
The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ): Baseline retinal characteristics (2019) (1)
Infectious, Inflammatory, Toxic and Other Optic Neuropathies (2008) (1)
I don't need my glasses, but... (2001) (1)
Non-arteritic anterior ischemic optic neuropathy with retinal emboli (2001) (1)
Giant cell arteritis: a medical emergency. (2008) (1)
Nonarteritic Anterior Ischemic Optic Neuropathy After Cataract Surgery: A Systematic Review and Meta-Analysis (2022) (1)
Eye Movements in Mild Traumatic Brain Injury: Ocular Biomarkers (2022) (1)
A window into eye movement dysfunction following mTBI: A scoping review of magnetic resonance imaging and eye tracking findings (2022) (0)
Title: Connexin43 Modulation Inhibits Scarring in a Rabbit Eye Glaucoma Trabeculectomy Model Running title: Inhibiting Scarring in a Rabbit Glaucoma Surgery Model Authors: Narmadai (2012) (0)
Monday 4th November (2013) (0)
Ocular syphilis in Pacific peoples-are we making misdiagnoses secondary to yaws? (2020) (0)
Development and Evaluation of a Neurological Hemifield Test (2008) (0)
Nailfold capillaroscopy abnormalities in primary open angle glaucoma (2018) (0)
Corneal sub-basal nerve plexus density in Parkinson’s disease (2016) (0)
In vivo evaluation of intravitreally injected connexin 43 mimetic peptide in reducing retinal ganglion cell loss and vessel leak after retinal ischemia (2014) (0)
Topographical Correlation Between Retinal Nerve Fiber Layer Thickness and Visual Field Sensitivity in Compressive Optic Neuropathy (2006) (0)
Corrigendum to “Visual symptoms in the presentation of Creutzfeldt–Jakob disease” [J. Clin. Neurosci. 22 (2015) 1688–1689] (2016) (0)
Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels (2017) (0)
Targeting the inflammasome pathway in retinal disease – an oral treatment for AMD and DR? (2017) (0)
Eye injuries and infections (2019) (0)
Functional Magnetic Resonance Imaging of the Visual Cortex in Unilateral Open-Angle Glaucoma (2012) (0)
Transpupillary Thermotherapy – A Novel Modality for Treating Diabetic Maculopathy (2005) (0)
Long term complications and vision loss following herpes zoster ophthalmicus (HZO) (2020) (0)
Focal Venous Congestion: A Mechanism for the Pathogenesis of Non-Arteritic Anterior Ischemic Optic Neuropathy (2007) (0)
Ophthalmic findings in cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS) (2016) (0)
Response to Survey. (2021) (0)
Monday 24th November (2014) (0)
Patient factors associated with appointment non-attendance at an ophthalmology department in Aotearoa New Zealand. (2023) (0)
Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease (2018) (0)
Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia (2015) (0)
Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks. (2023) (0)
PRE-OPERATIVE RETINAL NERVE FIBRE LAYER THICKNESS PREDICTS VISUAL RECOVERY FOLLOWING SURGICAL INTERVENTION IN PATIENTS WITH COMPRESSIVE OPTIC NEUROPATHY (2010) (0)
404: Management of acute optic neuritis: Survey of ophthalmologists and neurologists in Australia and New Zealand (2008) (0)
Epiretinal membrane: a reversible cause for visual disability in myotonic dystrophy (2012) (0)
Author's Guidelines - abridged version (2013) (0)
EB_A_361946 83..114 (2022) (0)
Epiretinal membrane in myotonic dystrophy type 1 (2012) (0)
Blocking Gap Junction Hemichannels Reduces Vascular Leak and Protects Ganglion Cells Following Retinal Ischemia (2012) (0)
Relative afferent pupillary defect, or afferent pupillary defect? – response (2006) (0)
Chapter 41 – Ischemic optic neuropathy (2010) (0)
Evaluation of diagnostic procedures, visual outcome and optic nerve morphology in giant cell arteritis (2004) (0)
Pre-Operative Retinal Nerve Fiber Layer Thickness Correlates With Degree of Visual Recovery Following Surgery in Patients With Compressive Optic Neuropathy (2007) (0)
Molecular Screening of Glaucoma Genes in Adult Glaucoma Supports the Role of CYP1B1 in Non-Congenital Glaucoma Phenotypes (2010) (0)
Interweaving neurology and ophthalmology Valerie Biousse Nancy J Newman (2010) (0)
T.P.54 Epiretinal membrane: A reversible cause for visual disability in myotonic dystrophy (2012) (0)
Evaluation of Optic Nerve Morphology in Non-glaucomatous Optic Neuropathies with Quantitative Optic Nerve Imaging Modalities (2013) (0)
Connexin43 Modulation Inhibits Scarring in a Rabbit Eye Glaucoma Trabeculectomy Model (2012) (0)
Optical coherence tomography findings in Huntington’s disease (2015) (0)
Modified connexin43 mimetic peptide shows higher efficacy in reducing retinal ganglion cell loss and vessel leak after retinal ischemia (2013) (0)
Tools for cup:disc ratio measurement – response (2006) (0)
Pathogenesis of Nonarteritic Anterior Ischemic Optic Neuropathy--Reply (2009) (0)
The effects of transiently raised IOP on retinal function and retinal ganglion cell loss in an animal model (2016) (0)
Shutting down the inflammasome pathway in diabetic retinopathy (2017) (0)

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Other Resources About Helen Danesh-Meyer

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What Schools Are Affiliated With Helen Danesh-Meyer?

Helen Danesh-Meyer is affiliated with the following schools:

University of Auckland