Helen Hobbs
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American medical researcher
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Helen Hobbsbiology Degrees
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Helen Hobbsphilosophy Degrees
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Biology Philosophy
Helen Hobbs's Degrees
- PhD Human Genetics University of Texas Southwestern Medical Center
Why Is Helen Hobbs Influential?
(Suggest an Edit or Addition)According to Wikipedia, Helen Haskell Hobbs, M.D., is a professor at the University of Texas Southwestern Medical Center, and a Howard Hughes Medical Institute Investigator, who won a 2016 Breakthrough Prize in Life Sciences and the 2018 Harrington Prize for Innovation in Medicine. She and Jonathan C. Cohen found that people with hypomorphic PCSK9 mutations had lower LDL-cholesterol levels and were almost immune to heart disease. This finding led to the development of a new class of cholesterol-lowering drugs that mimic the effects of the PCSK9 mutations. She and Jonathan Cohen also identified the first genetic risk factor for fatty liver disease, a burgeoning health problem that can lead to cirrhosis and liver cancer. Their laboratory has shown that mutation in PNPLA3 causes accumulation of PNPLA3 on lipid droplets, which compromises the mobilization of triglycerides from liver cells. She sits on the Board of Directors at Pfizer.
Helen Hobbs's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Papers
- Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity (2004) (3534)
- Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. (2006) (2731)
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease (2008) (2629)
- Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor (1996) (2322)
- Human Fatty Liver Disease: Old Questions and New Insights (2011) (1835)
- Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. (2000) (1602)
- A Common Allele on Chromosome 9 Associated with Coronary Heart Disease (2007) (1497)
- Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. (2005) (1477)
- Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 (2005) (1261)
- Molecular genetics of the LDL receptor gene in familial hypercholesterolemia (1992) (1140)
- Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol (2004) (1118)
- Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. (1992) (913)
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease (2014) (883)
- Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion (2002) (746)
- High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase (2001) (725)
- The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. (1990) (716)
- Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β* (2002) (711)
- Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation* (2007) (702)
- Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. (2010) (630)
- Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. (2002) (622)
- Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. (2006) (608)
- Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein (2001) (579)
- A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis* (2009) (563)
- PCSK9: a convertase that coordinates LDL catabolism Published, JLR Papers in Press, November 19, 2008. (2009) (552)
- Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. (2003) (546)
- Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL (2007) (531)
- Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat. (1996) (530)
- Molecular biology of PCSK9: its role in LDL metabolism. (2007) (527)
- A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. (2006) (527)
- The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. (2004) (506)
- Genetic and metabolic determinants of plasma PCSK9 levels. (2009) (453)
- ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion* (2003) (452)
- Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. (2002) (447)
- A Protein‐Truncating HSD17B13 Variant and Protection from Chronic Liver Disease (2018) (422)
- Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis. (1991) (406)
- Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. (2006) (391)
- Atypical angiopoietin-like protein that regulates ANGPTL3 (2012) (378)
- Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. (2008) (377)
- Sequence Variations in PCSK 9 , Low LDL , and Protection against Coronary Heart Disease (2006) (336)
- A feed-forward loop amplifies nutritional regulation of PNPLA3 (2010) (327)
- Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8* (2003) (312)
- Molecular definition of the extreme size polymorphism in apolipoprotein(a). (1993) (310)
- Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis (2014) (304)
- Common low-density lipoprotein receptor mutations in the French Canadian population. (1990) (304)
- Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. (1995) (301)
- Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia. (1987) (286)
- Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis (2013) (284)
- Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands* (2006) (264)
- Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. (2002) (262)
- Structure and Localization of the Human Gene Encoding SR-BI/CLA-1 (1997) (252)
- Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. (2012) (241)
- Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease* (2011) (241)
- Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). (1993) (238)
- Adiposity Amplifies the Genetic Risk of Fatty Liver Disease Conferred by Multiple Loci (2017) (238)
- Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. (2002) (234)
- Expression of ABCG5 and ABCG8 Is Required for Regulation of Biliary Cholesterol Secretion* (2005) (225)
- ARH Is a Modular Adaptor Protein That Interacts with the LDL Receptor, Clathrin, and AP-2* (2002) (220)
- Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor (2008) (215)
- Crystal structure of the human sterol transporter ABCG5/ABCG8 (2016) (210)
- WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data (2006) (204)
- ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion (2014) (201)
- Two common low density lipoprotein receptor gene mutations cause familial hypercholesterolemia in Afrikaners. (1989) (199)
- The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation (2017) (188)
- Lipoprotein(a): intrigues and insights. (1999) (183)
- African Americans and Caucasians have a similar prevalence of coronary calcium in the Dallas Heart Study. (2004) (181)
- Mutations in ATP‐cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia (2001) (170)
- Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia (2010) (170)
- No Association Between Plasma Levels of Plant Sterols and Atherosclerosis in Mice and Men (2004) (170)
- Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a). (1998) (162)
- Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis (2019) (155)
- Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a). (1992) (154)
- Transport of Lipids from High and Low Density Lipoproteins via Scavenger Receptor-BI* (1999) (152)
- Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis (2002) (149)
- ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S] (2015) (146)
- Disruption of cholesterol homeostasis by plant sterols. (2004) (143)
- Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins* (2016) (143)
- Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors. (1989) (137)
- ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S] (2017) (133)
- Polyunsaturated fatty acids up-regulate hepatic scavenger receptor B1 (SR-BI) expression and HDL cholesteryl ester uptake in the hamster. (1999) (130)
- No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans. (1995) (129)
- Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle. (1994) (129)
- Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S] (2015) (128)
- Selective sterol accumulation in ABCG5/ABCG8-deficient mice Published, JLR Papers in Press, December 1, 2003. DOI 10.1194/jlr.M300377-JLR200 (2004) (128)
- Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia. (1986) (128)
- Expression of the VLDL receptor in endothelial cells. (1996) (127)
- Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus. (1994) (126)
- Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma. (1995) (123)
- Polymorphic DNA haplotypes at the LDL receptor locus. (1989) (123)
- Relative roles of ABCG5/ABCG8 in liver and intestine[S] (2015) (123)
- Dual roles for cholesterol in mammalian cells. (2005) (122)
- Relation between number of apolipoprotein(a) kringle 4 repeats and mobility of isoforms in agarose gel: basis for a standardized isoform nomenclature. (1996) (121)
- Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). (1997) (121)
- Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function*S⃞ (2009) (121)
- Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels. (1993) (119)
- Dissociation Between APOC3 Variants, Hepatic Triglyceride Content and Insulin Resistance (2011) (118)
- PNPLA3, CGI‐58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice (2019) (112)
- Scavenger Receptor, Class B, Type I-dependent Stimulation of Cholesterol Esterification by High Density Lipoproteins, Low Density Lipoproteins, and Nonlipoprotein Cholesterol* (1998) (109)
- Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface (2002) (109)
- ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500115-JLR200 (2005) (108)
- Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways (2015) (108)
- Tetranucleotide repeat polymorphism in the LPL gene. (1990) (104)
- A high frequency of length polymorphisms in repeated sequences adjacent to Alu sequences. (1990) (102)
- Cloning of the human cholesterol 7 alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12. (1992) (98)
- Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia* (2003) (97)
- Hepatic ANGPTL3 regulates adipose tissue energy homeostasis (2015) (97)
- Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR (2012) (97)
- Molecular mechanisms of autosomal recessive hypercholesterolemia (2003) (97)
- The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans. (1997) (90)
- Deletion of GPIHBP1 causing severe chylomicronemia (2011) (88)
- The Modular Adaptor Protein Autosomal Recessive Hypercholesterolemia (ARH) Promotes Low Density Lipoprotein Receptor Clustering into Clathrin-coated Pits* (2005) (85)
- ABC1: connecting yellow tonsils, neuropathy, and very low HDL. (1999) (85)
- Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a). (1996) (85)
- Missense Mutations in ABCG5 and ABCG8 Disrupt Heterodimerization and Trafficking* (2004) (81)
- Kringle-containing fragments of apolipoprotein(a) circulate in human plasma and are excreted into the urine. (1996) (81)
- Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction. (1993) (80)
- Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin. (2010) (77)
- Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions. (1988) (76)
- Developmental and hormonal regulation of murine scavenger receptor, class B, type 1. (1999) (76)
- Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance (2020) (74)
- Sterol Transfer by ABCG5 and ABCG8 (2006) (71)
- Molecular mechanisms of autosomal recessive hypercholesterolemia. (2002) (70)
- Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets (2018) (70)
- High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr−/− mice Published, JLR Papers in Press, June 1, 2004. DOI 10.1194/jlr.M400167-JLR200 (2004) (68)
- Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. (2007) (62)
- Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene. (1985) (62)
- The Modular Adaptor Protein ARH Is Required for Low Density Lipoprotein (LDL) Binding and Internalization but Not for LDL Receptor Clustering in Coated Pits* (2004) (61)
- The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. (1986) (60)
- Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes (2008) (57)
- Overexpression of ABCG 5 and ABCG 8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol (2018) (56)
- Lipoprotein(a) and Apolipoprotein(a) Isoforms: No Association With Coronary Artery Calcification in The Dallas Heart Study (2005) (56)
- Molecular basis of familial hypercholesterolemia. (1989) (54)
- ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice (2017) (53)
- Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8 Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500124-JLR200 (2005) (52)
- Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride (2018) (49)
- Molecular genetics of lipoprotein (a): new pieces to the puzzle. (1994) (49)
- Deletion in the first cysteine-rich repeat of low density lipoprotein receptor impairs its transport but not lipoprotein binding in fibroblasts from a subject with familial hypercholesterolemia. (1988) (48)
- Human LDL receptor gene: HincII polymorphism detected by gene amplification. (1988) (48)
- Kinetic characteristics and regulation of HDL cholesteryl ester and apolipoprotein transport in the apoA-I-/- mouse. (1998) (47)
- Simple Genetics for a Complex Disease (2013) (45)
- Expression of human apolipoprotein B90 in transgenic mice. Demonstration that apolipoprotein B90 lacks the structural requirements to form lipoprotein. (1994) (45)
- Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice. (1995) (42)
- Patatin‐like phospholipase domain‐containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease (2010) (42)
- Sequence microheterogeneity in apolipoprotein(a) gene repeats and the relationship to plasma Lp(a) levels. (1995) (42)
- Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China (2012) (41)
- Functional Asymmetry of Nucleotide-binding Domains in ABCG5 and ABCG8* (2006) (41)
- APOC3, coronary disease, and complexities of Mendelian randomization. (2014) (40)
- Human LDL receptor gene: two ApaLI RFLPs. (1987) (40)
- Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. (2008) (39)
- Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA. (1993) (38)
- Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency. (2015) (35)
- Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice (2018) (35)
- Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin (2017) (34)
- Identification of a VLDL‐induced, FDNPVY‐independent internalization mechanism for the LDLR (2007) (33)
- HSD17B13 and Chronic Liver Disease in Blacks and Hispanics. (2018) (32)
- Dinucleotide repeat polymorphism at the 3' end of the LDL receptor gene. (1990) (32)
- Tetranucleotide repeat polymorphism in the apolipoprotein B gene. (1990) (30)
- Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology (2012) (29)
- ANGPTL8 has both endocrine and autocrine effects on substrate utilization (2020) (29)
- Human growth hormone increases apo(a) expression in transgenic mice. (1999) (28)
- Sequences in the Nonconsensus Nucleotide-binding Domain of ABCG5/ABCG8 Required for Sterol Transport* (2011) (27)
- Tetranucleotide length polymorphism 5' of the alpha 2-macroglobulin receptor (A2MR)/LDL receptor-related protein (LRP) gene. (1994) (27)
- EcoN I polymorphism in the human cholesteryl ester transfer protein (CEPT) gene. (1990) (25)
- Molecular basis of cholesterol efflux via ABCG subfamily transporters (2021) (25)
- Sequence diversity in genes of lipid metabolism. (2001) (23)
- Transgenic mice expressing a human apolipoprotein[a] allele. (1999) (22)
- Low density lipoprotein kinetics in a family having defective low density lipoprotein receptors in which hypercholesterolemia is suppressed. (1991) (20)
- High plasma levels of apo(a) fragments in Caucasians and African‐Americans with end‐stage renal disease: implications for plasma Lp(a) assay (1997) (19)
- No association between polymorphism in PEMT (V175M) and hepatic triglyceride content in the Dallas Heart Study (2006) (18)
- CGG triple repeat polymorphism in VLDL receptor (VLDL-R) gene. (1994) (18)
- High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr (cid:2) / (cid:2) mice (2004) (17)
- Determinants of human apolipoprotein [a] secretion from mouse hepatocyte cultures. (2001) (12)
- Tetranucleotide repeat polymorphism in the apolipoprotein C-III gene. (1990) (9)
- Erratum: Patatin-like phospholipase domain-containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets (Journal of Biological Chemistry (2018) 293 (6958-6968) DOI: 10.1074/jbc.RA118.002333) (2018) (9)
- Lipoprotein(a) and growth hormone: is the puzzle solved? (1997) (8)
- Genetic defenses against hypercholesterolemia. (2002) (7)
- Transgenic Mice Expressing High Plasma Concentrations of Human Apolipoprotein B 100 and Lipoprotein ( a ) (2013) (7)
- Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8 (2021) (6)
- Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats (2021) (6)
- Contribution of a genetic risk score to ethnic differences in fatty liver disease (2022) (5)
- Corrigendum: Low LDL cholesterol in African Americans resulting from frequent nonsense mutations in PCSK9 (2005) (5)
- Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets. (2018) (4)
- Author response: Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways (2015) (4)
- Genetic factors that contribute to interindividual variations in plasma low density lipoprotein-cholesterol levels. (1996) (3)
- Reply: HEPATOLOGY, Vol. XX, No. X, 2015 CORRESPONDENCE (2016) (3)
- Hepatic triglyceride content in individuals with reduced intestinal cholesterol absorption due to variants in Nieman Pick C1‐like 1 (2011) (2)
- Erratum: African Americans and Caucasians have a similar prevalence of coronary calcium in the Dallas heart study (Journal of the American College of Cardiology (2004) 44 (1011-1017) PII: S0735-1097(04)01218-5 and DOI: 10.1016/j.jacc.2004.05.069) (2004) (2)
- ABC transporters and human disease: From cholestasis to heart disease (2003) (2)
- Abstract 13164: Tm6sf2 is a Regulator of Liver Fat Metabolism in Smooth Er Influencing Vldl Lipidation (2020) (1)
- LDL Receptor Mutations in Patients with Familial Hypercholesterolemia (1987) (1)
- Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance (2020) (1)
- Author response: Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin (2017) (1)
- Analysis of mice expressing human apo(a) and apo B-100 transgenes (1994) (1)
- Artigo recomendado do mês: Sequence variations in PCSK9, low LDL, and protection against coronary heart disease (2006) (1)
- Genetics and molecular biology. (1994) (0)
- P299 RELATIVE RESPONSIVENESS TO LDL-LOWERING AGENTS THAT BLOCK CHOLESTEROL ABSORPTION (EZETIMIBE) AND INHIBIT CHOLESTEROL SYNTHESIS (SIMVASTATIN) (2010) (0)
- 1993 Aspen Cholesterol/Bile Acid Conference: diet and gene interactions in cholesterol metabolism. (1994) (0)
- We-W30:1 Genetic determinants of plasma lipoproteins (2006) (0)
- Lawrence Berkeley National Laboratory Recent Work Title Relationship between genetic variation at PPP 1 R 3 B and levels of liver glycogen and triglyceride Permalink (2018) (0)
- ARH mutations and hypercholesterolaemia in Sardinia. Authors' reply (2002) (0)
- Mutational Analysis of a Menabrane Protein (1990) (0)
- Structural Role of ABCG5/ABCG8 in Sterol Transport (2017) (0)
- Reply (2016) (0)
- ARH mutations and hypercholesterolaemia in Sardinia (2002) (0)
- Abstract 20402: Exome Genotyping of Dallas Heart Study Reveals Putative Cardiac Disease-Causing Mutations: Disconnect Between Genotype and Phenotype (2014) (0)
- Homozygosity for the Q136X mutation within the ARH gene results in delayed in vivo LDL catabolism (2003) (0)
- Genetics and Cardiovascular Disease: Are We Getting to the Heart of the Matter? (2010) (0)
- Ethnic differences in coronary artery disease: presentation, progression and prognosis (1999) (0)
- Apo(a) Expression in Transgenic Mice a (1994) (0)
- Linkage analysis of anorexia nervosa in a large family with multiple affected individuals (2001) (0)
- Beth Levine M.D. Prize in Autophagy Research. (2021) (0)
- 236 Single nucleotide polymorphism rs873549 is associated with keloids in an African-American population (2017) (0)
- Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease (2021) (0)
- Tu-PL2:4 Genetic protection from coronary atherosclerosis: From genes to public health (2006) (0)
- Defects in TM6SF2 Impairs Lipidation of Nascent VLDL and Leads to Accumulation of Liver Fat (2018) (0)
- Hypolipidemia associated with inactivation of TM6SF2 is due to decreased VLDL-lipids secretion (2021) (0)
- Abstract 1022: Genetic Deficiency of Proprotein Convertase Subtilisin/Kexin 9: Identification of a Compound Heterozygote with no PCSK9 (2006) (0)
- Chapter 313 CHAPTER 8 DISORDERS OF LIPOPROTEIN METABOLISM (0)
- Expression of Human Apolipoprotein BlOO in Transgenic Mice EDITING OF HUMAN APOLIPOPROTEIN BlOO mRNA* (2001) (0)
- Site-directed mutagenesis studies of h 15-LOX-1 and their effects on inhibitor potency (2015) (0)
- Beth Levine M.D. Prize in Autophagy Research (2021) (0)
- Genetics, metabolism and atherogenicity of LP(A) (1997) (0)
- Genetics and molecular biology. (1995) (0)
- Beth Levine M.D. Prize in Autophagy Research. (2021) (0)
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