Helen Piwnica‐worms
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Biology
Helen Piwnica‐worms's Degrees
- PhD Biochemistry University of California, San Francisco
- Bachelors Biochemistry University of California, Davis
Why Is Helen Piwnica‐worms Influential?
(Suggest an Edit or Addition)Helen Piwnica‐worms's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. (1997) (1469)
- Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. (1997) (1386)
- ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1 (2001) (1082)
- Whole Genome Analysis Informs Breast Cancer Response to Aromatase Inhibition (2012) (998)
- The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element (1989) (902)
- Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. (1992) (690)
- Use of an oriented peptide library to determine the optimal substrates of protein kinases (1994) (636)
- The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01* (2000) (607)
- Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints (2002) (507)
- Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src (1987) (474)
- Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5 (1993) (462)
- Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. (2000) (436)
- Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. (2004) (391)
- Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. (2018) (375)
- Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1 (1998) (374)
- The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex (1997) (374)
- Lack of PTEN sequesters CHK1 and initiates genetic instability. (2005) (344)
- Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation (1994) (315)
- Atypical PKC Phosphorylates PAR-1 Kinases to Regulate Localization and Activity (2004) (296)
- C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (2001) (289)
- A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. (1999) (277)
- Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. (2011) (271)
- Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A (1998) (267)
- Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication. (1990) (257)
- Contribution of p53 to metastasis. (2014) (257)
- p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. (1992) (250)
- Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate (1988) (242)
- C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. (1998) (241)
- Comprehensive Proteomic Analysis of Interphase and Mitotic 14-3-3-binding Proteins* (2004) (228)
- 14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity (1998) (223)
- Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding (2003) (222)
- Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding (2001) (221)
- Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. (2012) (203)
- Absence of Apparent Phenotype in Mice Lacking Cdc25C Protein Phosphatase (2001) (201)
- The human decatenation checkpoint (2001) (196)
- A‐ and B‐type cyclins differentially modulate substrate specificity of cyclin‐cdk complexes. (1993) (194)
- cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. (1992) (188)
- Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. (1991) (185)
- cdc2 gene expression at the G1 to S transition in human T lymphocytes. (1990) (182)
- Phosphorylation of Chk1 by ATR Is Antagonized by a Chk1-Regulated Protein Phosphatase 2A Circuit (2006) (181)
- Dual phosphorylation controls Cdc25 phosphatases and mitotic entry (2003) (176)
- DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding (1999) (167)
- Mechanisms of p34cdc2 regulation (1993) (167)
- Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. (2003) (166)
- Patient-derived xenograft (PDX) models in basic and translational breast cancer research (2016) (166)
- GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. (2008) (163)
- Noninvasive imaging of protein–protein interactions in living animals (2002) (163)
- Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases (2005) (163)
- Phosphorylation and inactivation of the mitotic inhibitor Weel by the nim1/cdr1 kinase (1993) (163)
- LKB1 regulates pancreatic beta cell size, polarity, and function. (2009) (153)
- Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. (2006) (151)
- Cell cycle: Fools rush in (1999) (146)
- Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state (2019) (143)
- Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. (2007) (142)
- Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein. (1991) (139)
- DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. (2009) (128)
- Cell cycle regulation of the p34cdc2 inhibitory kinases. (1994) (127)
- Overproduction of Human Myt1 Kinase Induces a G2 Cell Cycle Delay by Interfering with the Intracellular Trafficking of Cdc2-Cyclin B1 Complexes (1999) (127)
- CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. (2017) (126)
- Serine Phosphorylation-dependent Association of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1 with 14-3-3β Protein* (1997) (113)
- UCN-01 Abrogates G2 Arrest through a Cdc2-dependent Pathway That Is Associated with Inactivation of the Wee1Hu Kinase and Activation of the Cdc25C Phosphatase* (1998) (111)
- Neoadjuvant Talazoparib for Patients With Operable Breast Cancer With a Germline BRCA Pathogenic Variant. (2020) (110)
- A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer (2012) (100)
- 14-3-3 binding regulates catalytic activity of human Wee1 kinase. (2001) (99)
- Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway (2002) (97)
- Immune System Dysfunction and Autoimmune Disease in Mice Lacking Emk (Par-1) Protein Kinase (2001) (96)
- Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216. (1994) (94)
- Activation of p34cdc2 kinase by cyclin A (1991) (89)
- Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo (2007) (83)
- Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion (2009) (81)
- Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. (1986) (79)
- Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. (2018) (79)
- mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15. (1994) (79)
- Identification of a 95-kDa WEE1-like tyrosine kinase in HeLa cells. (1995) (78)
- The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators* (2001) (77)
- Reversible tyrosine phosphorylation and cell cycle control. (1993) (75)
- The Par-1/MARK Family of Protein Kinases: From Polarity to Metabolism (2007) (74)
- High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer (2018) (72)
- Type I interferons link viral infection to enhanced epithelial turnover and repair. (2015) (72)
- New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases (2006) (71)
- Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival (2015) (69)
- Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells (2012) (69)
- Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity. (1990) (66)
- Rapid and transient localization of the leader RNA of vesicular stomatitis virus in the nuclei of infected cells. (1982) (65)
- Casein Kinase 1 Functions as both Penultimate and Ultimate Kinase in Regulating Cdc25A Destruction (2010) (64)
- Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex. (1992) (64)
- A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies (2010) (60)
- CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction (2012) (58)
- Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. (1992) (57)
- Okazaki Fragment Processing-independent Role for Human Dna2 Enzyme during DNA Replication* (2012) (56)
- The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing (2020) (54)
- The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus (1988) (53)
- Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. (2011) (52)
- A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations (2020) (52)
- Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association (2008) (51)
- Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit (2008) (51)
- Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis (2010) (48)
- A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity (2017) (47)
- Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth (2016) (46)
- Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells (1988) (45)
- The Polarity Protein Par1b/EMK/MARK2 Regulates T Cell Receptor-Induced Microtubule-Organizing Center Polarization1 (2009) (43)
- Human Cytomegalovirus Protein pUL117 Targets the Mini-Chromosome Maintenance Complex and Suppresses Cellular DNA Synthesis (2010) (41)
- Sphingosine-kinase-1 signaling promotes metastasis of triple-negative breast cancer. (2019) (39)
- Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells (1990) (39)
- Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. (2019) (39)
- p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer (2016) (39)
- Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379 (2008) (38)
- CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. (2018) (36)
- Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase. (2006) (36)
- Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells (2011) (32)
- Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo (1986) (30)
- A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis (2018) (28)
- Forkhead Box O1 (FOXO1) Protein, but Not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice* (2013) (28)
- Sequential synthesis of small capped RNA transcripts in vitro by vesicular stomatitis virus. (1983) (25)
- Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand* (2015) (25)
- Purification and biochemical characterization of non-myristoylated recombinant pp60c-src kinase. (1992) (25)
- Fasting reduces intestinal radiotoxicity enabling dose-escalated radiotherapy for pancreatic cancer. (2019) (24)
- Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. (2019) (23)
- Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-suppressive Activity of Profilin-1* (2015) (23)
- 14-3-3 Proteins Restrain the Exo1 Nuclease to Prevent Overresection* (2015) (21)
- Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity (2014) (20)
- A pilot study of neoadjuvant talazoparib for early-stage breast cancer patients with a BRCA mutation (2016) (20)
- Cdc25A Regulation: To Destroy or Not to Destroy, Is That the Only Question? (2003) (20)
- Contributions Made by CDC25 Phosphatases to Proliferation of Intestinal Epithelial Stem and Progenitor Cells (2011) (20)
- 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers (2019) (19)
- Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. (2015) (19)
- BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation (2018) (18)
- Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells (2021) (15)
- Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study. (2019) (14)
- Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry. (2007) (13)
- A human Cds 1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage (1999) (12)
- Abstract GS5-05: Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant state (2019) (11)
- Tyrosine phosphorylation in signal transduction. (1988) (11)
- p107wee1 is a serine/threonine and tyrosine kinase that promotes the tyrosine phosphorylation of the cyclin/p34cdc2 complex. (1991) (11)
- Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine (2021) (11)
- Maintenance of Insect Cell Cultures and Generation of Recombinant Baculoviruses (2004) (10)
- Intratumoral Heterogeneity in Ductal Carcinoma In Situ: Chaos and Consequence (2018) (10)
- Reversible phosphorylation and mitotic control. (1996) (10)
- Stem cell enriched-epithelial spheroid cultures for rapidly assaying small intestinal radioprotectors and radiosensitizers in vitro (2018) (7)
- Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. (1985) (7)
- Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer (2021) (7)
- Expression and Purification of Recombinant Proteins Using the Baculovirus System (2004) (7)
- Activation of p34 cd 2 Kinase by Cyclin A (2002) (7)
- Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer (2020) (7)
- 14-3-3 Binding Regulates Catalytic Activity of Human Wee 1 Kinase 1 (2001) (7)
- Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast (2021) (7)
- Overview of the Baculovirus Expression System (2000) (6)
- A randomized, triple negative breast cancer enrolling trial to confirm molecular profiling improves survival (ARTEMIS). (2017) (5)
- Differentiation of myeloid cells is accompanied by increased levels of pp 6 Oc-src protein and kinase activity ( myeloid leukemia / bone marrow / tumor promoter / cellular oncogene ) (5)
- EFFECTS OF CELL EXTRACTS ON TRANSCRIPTION BY VIRION AND INTRACELLULAR NUCLEOCAPSIDS OF VESICULAR STOMATITIS VIRUS (1984) (5)
- Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer (2021) (5)
- Mechanism of activation of complexed pp60c-src by the middle T antigen of polyomavirus. (1989) (4)
- C-TAKI Protein Kinase Phosphorylates Human Cdc 25 C on Serine 216 and Promotes 14-3-3 Protein Binding 1 (2005) (3)
- Erratum: Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models (Journal of Clinical Investigation (2012) 122, 4 (1541-1552) DOI: 10.1172/JCI58765) (2012) (3)
- HIF2 Regulates Intestinal Wnt5a Expression (2021) (3)
- Overview of the Baculovirus Expression System (2004) (3)
- Contributions Made by CDC 25 Phosphatases to Proliferation of Intestinal Epithelial Stem and Progenitor Cells (2016) (3)
- Abstract B72: Combining immune checkpoint inhibition and DNA damage repair (DDR) targeted therapy in small cell lung cancer (SCLC) (2017) (3)
- Delineating longitudinal patterns of response to neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized, TNBC enrolling trial to confirm molecular profiling improves survival (ARTEMIS; NCT02276443). (2019) (3)
- The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors (2021) (2)
- Abstract 4669: Overcoming therapy resistance in stem cell-rich triple negative breast cancer through p38 MAP kinase inhibition (2019) (2)
- Mechanisms ofp34cdc2 Regulation (1993) (2)
- Abstract 2181: Functionalizing intratumoral signaling heterogeneity in triple negative breast cancer (2018) (2)
- Clinical and correlative science results in a phase II study of UCN-01 in combination with irinotecan in recurrent triple-negative breast cancer (TNBC). (2012) (2)
- Abstract CT076: Women's triple-negative, first-line treatment: Improving outcomes in triple-negative breast cancer using molecular triaging and diagnostic imaging to guide neoadjuvant therapy (2016) (1)
- Mitonc- and g2 checkpoint-control (1998) (1)
- Abstract P6-03-05: Risk of needle-track seeding with serial ultrasound guided biopsies in triple negative breast cancer (2018) (1)
- Abstract P2-16-09: Residual cancer burden in patients with early stage triple negative breast cancer who progress on anthracycline-based neoadjuvant chemotherapy in an ongoing clinical trial (ARTEMIS) (2020) (1)
- Toward an Understanding of the Eukaryotic Cell Cycle: A Biochemical Approach (1993) (1)
- Abstract 1513: Analysis of spatiotemporal phenotypic heterogeneity in chemoresistant triple negative breast cancer using imaging mass cytometry (2020) (1)
- Patient-derived xenograft (PDX) models in basic and translational breast cancer research (2016) (1)
- Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers (2022) (1)
- Women’s triple-negative, first-line treatment: Improving outcomes in triple-negative breast cancer (TNBC) using molecular triaging and diagnostic imaging to guide neoadjuvant therapy (NACT). (2015) (1)
- Abstract PR01: Analysis of spatiotemporal phenotypic heterogeneity in chemoresistant triple negative breast cancer using imaging mass cytometry (2020) (1)
- Abstract 5316: Check point kinase 1 (Chk1) targeting as a novel therapeutic strategy in small cell lung cancer (SCLC) (2015) (1)
- p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer (2016) (1)
- Improving outcomes in triple-negative breast cancer (TNBC) using molecular characterization and diagnostic imaging to identify and treat chemo-insensitive disease (2016) (1)
- Overview of the Baculovirus Expression System (1995) (1)
- Abstract OT2-01-20: Phase IIB study of neoadjuvant panitumumab combined with carboplatin and paclitaxel (PaCT) for anthracycline-resistant triple-negative breast cancer (TNBC) (2017) (0)
- Abstract P1-03-01: A novel model to study to metaplastic TNBC (2020) (0)
- A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations (2020) (0)
- Abstract 2322: Targeting glutamine transporter (ASCT2) inhibits metabolic stress-induced GD2+ cancer stem cell-like phenotype in triple-negative breast cancer (2021) (0)
- Abstract 4164: Fasting protects mice from lethal radiation by promoting small intestinal stem cell survival (2018) (0)
- FOXO1 induces p21 expression during fasting 1 Forkhead Box O1 (FOXO1), but not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice* (2013) (0)
- High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer (2018) (0)
- Abstract 4708: Investigating triple negative breast cancer phenotypic heterogeneity of human and patient-derived xenograft samples using imaging mass cytometry (2019) (0)
- Abstract OT3-2-05: Improving outcomes in triple-negative breast cancer (TNBC) using molecular triaging and diagnostic imaging to guide neoadjuvant therapy (2015) (0)
- Purification andFunctional Properties ofSimian Virus40Largeand SmallTAntigens Overproduced inInsect Cells (1988) (0)
- Abstract P6-01-08: Identifying metastatic drivers in patient derived xenograft models of triple negative breast cancer (2017) (0)
- Abstract P4-07-02: Targeted therapies for TNBC: Exploiting vulnerabilities that arise from DNA damage repair pathway dependencies (2016) (0)
- Cyclin A/CDK2BindsDirectly toE2F-1andInhibits the DNA-Binding Activity ofE2F-1/DP-1 byPhosphorylation (1994) (0)
- Abstract OT2-03-03: Women's triple-negative, first-line treatment: Improving outcomes in triple-negative breast cancer using molecular triaging and diagnostic imaging to guide neoadjuvant therapy (2016) (0)
- A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity (2017) (0)
- Serine 379 Signaling through Autophosphorylation of Regulation of Chk2 Ubiquitination and (2014) (0)
- Reversible phosphorylation and cell cycle control (1997) (0)
- 243 Targeting the Chk1/Cdc25A pathway in p53-deficient tumors (2010) (0)
- Abstract A108: DNA damage repair targeting upregulates PD-L1 level and potentiates the effect of PD-L1 blockade in small cell lung cancer (2018) (0)
- Abstract 212: High-resolution barcoding in patient-derived xenografts of triple-negative breast cancer reveals reversible chemoresistance conferred by non-mutational mechanisms (2018) (0)
- Abstract P3-07-01: Towards a therapeutically relevant subtyping scheme for triple-negative breast cancer (TNBC), profiling results from A Randomized, TNBC Enrolling trial to confirm Molecular profiling Improves Survival (ARTEMIS) (2019) (0)
- Abstract P3-06-04: Investigating clonal dynamics in triple negative breast cancer chemoresistance (2016) (0)
- Cdc25B and Cdc25C Protein Phosphatases Responses in Mice and Cells Lacking Normal Cell Cycle and Checkpoint (2014) (0)
- Abstract P4-03-02: Characterizing and targeting chemoresistant subclones in patient-derived xenograft models of triple negative breast cancer (2018) (0)
- Abstract P1-15-06: Impact of serial biopsies in triple-negative breast cancer patients receiving neoadjuvant systemic therapy (2019) (0)
- Abstract 5172: A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis (2018) (0)
- Abstract P2-05-08: p53 deficiency enhances metastatic potential of triple negative breast cancer by promoting growth in primary and metastatic sites (2016) (0)
- Abstract OT2-01-22: NCT02456857: A phase II trial of liposomal doxorubicin, bevacizumab and everolimus (DAE) in patients (pts) with localized triple-negative breast cancer (TNBC) with tumors predicted insensitive to standard neoadjuvant chemotherapy (NACT) (2017) (0)
- Abstract 4106: High throughput chemical profiling of chemoresistant triple negative breast cancer (2020) (0)
- Abstract B59: Multiparametric imaging to evaluate human and mouse breast carcinoma in situ (2018) (0)
- The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors (2021) (0)
- Expression and Purification of Recombinant Proteins Using the Baculovirus System (2018) (0)
- The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing (2020) (0)
- Abstract 2316: Fasting protects mice from lethal DNA damage by promoting small intestinal stem cell survival and by inhibiting acute inflammation (2015) (0)
- Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer (2023) (0)
- Activity of Class IIa Histone Deacetylases C-TAK 1 in Regulating Localization and New Role for hPar-1 Kinases EMK and (2006) (0)
- Abstract PS11-17: Combination PI3K and NOS targeted therapy for metaplastic breast cancer (2021) (0)
- Abstract P3-07-03: Withdrawn (2019) (0)
- PCNA-Independent Destruction Targets CHK1 for CDT2 CRL4 (2014) (0)
- HUMAN CDC25A CATALYTIC DOMAIN (1998) (0)
- A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis (2018) (0)
- Abstract P5-17-04: Combined PI3K and NOS inhibition enhances efficacy of taxane-based chemotherapy in metaplastic breast cancer (2022) (0)
- Abstract P5-05-01: A molecularly annotated collection of breast cancer patient-derived xenograft models aligned with ongoing clinical trials built from fine needle aspiration samples throughout neoadjuvant treatment (2018) (0)
- Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation (2019) (0)
- Abstract GS4-02: Investigating genomic and phenotypic evolution of triple negative breast cancer chemoresistance and metastasis in patient-derived xenografts (2020) (0)
- Abstract P4-06-03: An annotated collection of pre- and post-therapy breast cancer patient-derived xenograft models built from fine needle aspiration samples aligned with ongoing clinical trials documenting response to treatment (2017) (0)
- Abstract 2822: Single-cell evaluation to identify tumor-stroma niches driving the transition from in situ to invasive breast cancer (2020) (0)
- , Saeko Serine 379 Signaling through Autophosphorylation of Regulation of Chk 2 Ubiquitination and (2008) (0)
- Abstract P4-08-05: NOS inhibition reverses epithelial-to-mesenchymal transition and synergizes with alpelisib in metaplastic breast cancer (2023) (0)
- Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers (2022) (0)
- Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells (2018) (0)
- Direct Inhibition of p107WEE1 by the Nim 1/CDR 1 Kinase (1994) (0)
- Abstract 1792: FGFR3 mediated PARP1 tyrosine 158 phosphorylation promotes PARP inhibitor resistance (2022) (0)
- Microtubule-Organizing Center Polarization Regulates T Cell Receptor-Induced The Polarity Protein Par 1 b / EMK / MARK 2 (2009) (0)
- Abstract 2406: Identifying and targeting chemoresistant subclones in triple negative breast cancer (2016) (0)
- Abstract 1497: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized trial (ARTEMIS; NCT02276443) (2020) (0)
- Abstract P2-16-08: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized, TNBC enrolling trial to confirm molecular profiling improves survival (ARTEMIS; NCT02276443) (2020) (0)
- Targeted therapies for triple negative breast cancer based on TP53 status. (2009) (0)
- Abstract 2679: Immuno-oncology panel optimization for imaging mass cytometry and digital image analysis of tumor tissues (2020) (0)
- Abstract 1595: Analysis of spatiotemporal phenotypic heterogeneity in chemoresistant triple negative breast cancer using imaging mass cytometry (2022) (0)
- Abstract 2658: NOS inhibition augments PI3K inhibitor-induced DNA damage and mesenchymal-to-epithelial transition in metaplastic breast cancer (2022) (0)
- Targeting chemotherapy resistance in mesenchymal triple-negative breast cancer: a phase II trial of neoadjuvant angiogenic and mTOR inhibition with chemotherapy. (2023) (0)
- Stem cell enriched-epithelial spheroid cultures for rapidly assaying small intestinal radioprotectors and radiosensitizers in vitro (2018) (0)
- Purification and biochemical characterization of non-myristoylated recombinant pp 6 Oc-src kinase (2005) (0)
- Abstract P6-06-01: Comprehensive analysis of the DNA damage repair and maintenance pathways that regulate TNBC sensitivity to replication stress (2018) (0)
- Abstract 3746: Fasting in mice enables abdominal radiation dose escalation in the setting of pancreatic cancer by mitigating small intestinal toxicity (2019) (0)
- Investigating the Use of Targeted Therapies for Triple‐Negative Breast Cancer (2015) (0)
- Abstract A16: Metformin is a potential nontoxic adjuvant to enhance the efficacy of non-PDL1/PD-1 targeting immune therapies (2020) (0)
- Abstract P5-06-06: Comprehensive analysis of the DNA damage repair and maintenance pathways that regulate TNBC sensitivity to replication stress (2017) (0)
- Abstract LB-114: Using molecular imaging to identify modulators of breast cancer metastasis (2012) (0)
- Retrovirus Shuttle Vector forStudyofKinase Activities ofpp6Ocsrc Synthesized InVitro andOverproduced InVivo (1986) (0)
- Combination PI3K and NOS targeted therapy for metaplastic breast cancer (2020) (0)
- Reprogramming of H3K9bhb at Regulatory Elements is an Epigenetic Feature of Fasting in the Small Intestine (2020) (0)
- Abstract 2901: Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancer (2019) (0)
- Investigating the use of Chk1 Inhibitors for Triple‐Negative Breast Cancer (2016) (0)
- TheCarboxy Terminus ofpp60Csrc IsaRegulatory Domain andIsInvolved inComplex Formation withthe Middle-T Antigen ofPolyomavirus (1988) (0)
- Abstract P1-07-22: Androgen receptor positivity is associated with nodal disease in triple negative breast cancer (2018) (0)
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