Helena Edlund | Academic Influence

Helena Edlund's AcademicInfluence.com Rankings

Helena Edlund

Computer Science

#10989

World Rank

#11593

Historical Rank

Machine Learning

#5015

World Rank

#5077

Historical Rank

Artificial Intelligence

#5407

World Rank

#5481

Historical Rank

Database

#8011

World Rank

#8348

Historical Rank

computer-science Degrees

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Computer Science

Helena Edlund's Degrees

Masters Computer Science Uppsala University
Bachelors Computer Science Uppsala University

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Why Is Helena Edlund Influential?

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According to Wikipedia, Helena Edlund is a Swedish professor and molecular biologist. She received her Ph.D. from Umeå University in 1991. She is a professor in Molecular Developmental Biology at Umeå University where she researches Type 2 diabetes and β-cell function. She is one of the founders, along with Thomas Edlund and Olof Karlsson, of the biopharmaceutical company Betagenon.

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Helena Edlund's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Insulin-promoter-factor 1 is required for pancreas development in mice (1994) (1834)
Notch signalling controls pancreatic cell differentiation (1999) (1195)
IPF1, a homeodomain‐containing transactivator of the insulin gene. (1993) (918)
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. (1998) (886)
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells (1997) (707)
Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a CysHis domain (1990) (681)
The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. (1996) (563)
Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion (2008) (534)
Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas (1997) (466)
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. (2005) (413)
Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9 (1999) (381)
Increased islet apoptosis in Pdx1+/- mice. (2003) (341)
Organogenesis: Pancreatic organogenesis — developmental mechanisms and implications for therapy (2002) (337)
Pdx1 maintains β cell identity and function by repressing an α cell program. (2014) (286)
Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout (2003) (229)
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells (2003) (226)
Sequence-specific interactions of nuclear factors with the insulin gene enhancer (1986) (218)
β-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1 (2005) (206)
Attenuation of FGF signalling in mouse β-cells leads to diabetes (2000) (201)
Endocrine Cell Clustering During Human Pancreas Development (2009) (179)
Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas (2002) (179)
The Insulin Gene Promoter: A Simplified Nomenclature (1995) (174)
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development (2006) (170)
Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. (2005) (156)
MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. (2009) (148)
Attenuation of FGF signalling in mouse beta-cells leads to diabetes. (2000) (133)
Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning (1996) (127)
Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-Cells (2008) (124)
Pancreas: how to get there from the gut? (1999) (122)
Developmental biology of the pancreas. (2001) (122)
BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. (2007) (121)
Phosphorylation Marks IPF1/PDX1 Protein for Degradation by Glycogen Synthase Kinase 3-dependent Mechanisms* (2006) (109)
Nuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion (2005) (105)
Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic α- and β-Cells (1991) (95)
Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development (2003) (94)
The Type 2 Diabetes–Associated Gene Ide Is Required for Insulin Secretion and Suppression of α-Synuclein Levels in β-Cells (2013) (94)
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. (2005) (92)
The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site. (1995) (91)
IPF1, a homeodomain protein with a dual function in pancreas development. (1995) (89)
Factors controlling pancreatic cell differentiation and function (2001) (84)
sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. (2005) (81)
IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes. (2001) (81)
TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro. (2005) (80)
Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development. (2001) (77)
The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6 (2002) (74)
Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes. (1991) (74)
A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer. (1988) (71)
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner (2015) (69)
The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. (2011) (69)
Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance* (2015) (67)
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients. (2018) (66)
α-Cell Neogenesis in an Animal Model of IDDM (1997) (63)
Homeobox Gene Product Nkx 6.1 Immunoreactivity in Nuclei of Endocrine Cells of Rat and Mouse Stomach (1998) (59)
(cid:98) -Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the (cid:98) -cell phenotype and maturity onset diabetes (1998) (55)
Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion. (2005) (42)
The 17,18‐epoxyeicosatetraenoic acid–G protein–coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques (2017) (41)
Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells. (1991) (33)
Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells (2007) (31)
Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Relationships of Monoclonal Antibodies in Children (2014) (31)
MFng Is Dispensable for Mouse Pancreas Development and Function (2009) (26)
Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport (2015) (25)
alpha-Cell neogenesis in an animal model of IDDM. (1997) (23)
Toward a renewable source of pancreatic β-cells (2008) (22)
Gastric Amylin Expression: Cellular Identity and Lack of Requirement for the Homeobox Protein PDX-1. A Study in Normal and PDX-1-Deficient Animals with a Cautionary Note on Antiserum Evaluation (1999) (22)
Magnitude of Increased Infliximab Clearance Imposed by Anti-infliximab Antibodies in Crohn’s Disease Is Determined by Their Concentration (2016) (20)
Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes. (2001) (19)
The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity. (2009) (19)
- Cell Pdx 1 Expression Is Essential for the Glucoregulatory , Proliferative , and Cytoprotective Actions of Glucagon-Like Peptide-1 (2005) (17)
Overexpression of extracellular-SOD in islets of nonobese diabetic mice and development of diabetes. (2002) (16)
α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice (2020) (16)
The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice (2016) (16)
First-in-human study of AZD5153, a small molecule inhibitor of bromodomain protein 4 (BRD4), in patients (pts) with relapsed/refractory (RR) malignant solid tumor and lymphoma: Preliminary data. (2019) (15)
Insulin promoter factor-1 controls several aspects of beta-cell identity. (2001) (12)
Population Pharmacokinetics of the BTK Inhibitor Acalabrutinib and its Active Metabolite in Healthy Volunteers and Patients with B-Cell Malignancies (2019) (12)
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival (2018) (8)
Exposure–response analysis of acalabrutinib and its active metabolite, ACP‐5862, in patients with B‐cell malignancies (2021) (5)
Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP‐5862, in patients with B‐cell malignancies and in healthy subjects using a population pharmacokinetic approach (2021) (5)
Gpr40 is expressed in enteroendocrine cells and mediates FFA stimulation of incretin secretion (2008) (3)
AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice (2021) (3)
Homeodomain Proteins in Pancreas Development (2001) (2)
Absence of Relationship Between Crohn's Disease Activity Index or C-Reactive Protein and Infliximab Exposure Calls for Objective Crohn's Disease Activity Measures for the Evaluation of Treatment Effects at Treatment Failure. (2019) (2)
Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice (2021) (2)
Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers. (2022) (2)
Islet differentiation and development: the background to stem cell therapy (2004) (1)
Population Pharmacokinetics of Bruton Tyrosine Kinase Inhibitor, Acalabrutinib, in Healthy Volunteers and Patients with B-Cell Malignancies (2017) (1)
Absence of relationship between CDAI or CRP and infliximab exposure calls for objective Crohn's disease activity measures for the evaluation of treatment effects at treatment failure. (2019) (1)
Correlation between progression-free and overall survival in a meta-analysis of aggregated survival data from patients with non-small cell lung cancer (2017) (0)
Genetic analysis of MFng in mouse pancreas (2008) (0)
Increased beta cell mass in mice where FGFR1c is expressed in alpha cells (2009) (0)
Cis- and transacting elements regulating insulin gene transcription (1989) (0)
Abstract 3023: Exposure versus efficacy/safety of acalabrutinib and its pharmacologically active metabolite, ACP-5862, for the treatment of chronic lymphocytic leukemia (2020) (0)
The structure of a human genomic cosmid containing a novel cluster of IFN-alfa genes (1983) (0)
expression and functional analysis of Id genes in the developing mouse pancreas (2008) (0)
Diabetes and β-cell hyperplasia in mice over-expressing the ATPase Asna-1 (2008) (0)
Cell Differentiation and Growth Developmental Biology of the Pancreas (2001) (0)
Overgrowth of developing mouse pancreas following ovrexpression of FGF10: European Association for the Study of Diabetes (EASD), September 2001 (2001) (0)
Abstract 4761: Joint model of longitudinal tumor size and overall survival (OS) in non-small cell lung cancer (NSCLC): A Bayesian approach (2018) (0)
Persistent FGF signalling in b-cells leads to diabetes in mice (2005) (0)
Tu1285 Relationship Between Measures of Infliximab Exposure and Clinical Outcome of Infliximab Intensification At Therapeutic Failure in Crohn's Disease (2015) (0)

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