Henk L. M. Granzier

Henk L. M. Granzier's AcademicInfluence.com Rankings

Henk L. M. Granzier

Physics

#6067

World Rank

#7970

Historical Rank

Biophysics

#238

World Rank

#249

Historical Rank

physics Degrees

Download Badge

Physics

Henk L. M. Granzier's Degrees

PhD Biophysics University of Groningen
Masters Physics University of Groningen

Why Is Henk L. M. Granzier Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Henk L. M. Granzier's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Folding-unfolding transitions in single titin molecules characterized with laser tweezers. (1997) (1079)
Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments. (1995) (592)
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy (2002) (553)
The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System (2001) (551)
The giant protein titin: a major player in myocardial mechanics, signaling, and disease. (2004) (544)
Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy (2004) (441)
Differential expression of cardiac titin isoforms and modulation of cellular stiffness. (2000) (396)
Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (2001) (385)
Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity. (2000) (351)
Calcium-dependent molecular spring elements in the giant protein titin (2003) (346)
Muscle assembly: a titanic achievement? (1999) (342)
The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. (2003) (331)
The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity (1998) (315)
MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. (2005) (313)
Protein Kinase A Phosphorylates Titin’s Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes (2002) (301)
Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium (2004) (293)
Genetic Variation in Titin in Arrhythmogenic Right Ventricular Cardiomyopathy–Overlap Syndromes (2011) (286)
Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies (2001) (279)
Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension (2013) (277)
PKC Phosphorylation of Titin’s PEVK Element: A Novel and Conserved Pathway for Modulating Myocardial Stiffness (2009) (259)
Titin-Based Modulation of Calcium Sensitivity of Active Tension in Mouse Skinned Cardiac Myocytes (2001) (251)
Titin develops restoring force in rat cardiac myocytes. (1996) (240)
Nebulin regulates thin filament length, contractility, and Z‐disk structure in vivo (2006) (236)
Cardiac titin: an adjustable multi‐functional spring (2002) (230)
Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments (1998) (230)
Cardiac titin: a multifunctional giant. (2010) (229)
Titin-actin interaction in mouse myocardium: passive tension modulation and its regulation by calcium/S100A1. (2001) (227)
Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle. (2000) (218)
Alterations in the determinants of diastolic suction during pacing tachycardia. (2000) (205)
Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner (2005) (187)
Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring. (1999) (171)
Changes in Titin Isoform Expression in Pacing-Induced Cardiac Failure Give Rise to Increased Passive Muscle Stiffness (2002) (170)
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy (2013) (170)
Titin is a Target of Matrix Metalloproteinase-2: Implications in Myocardial Ischemia/Reperfusion Injury (2010) (167)
Research Priorities for Heart Failure With Preserved Ejection Fraction (2020) (152)
Characterization of nebulette and nebulin and emerging concepts of their roles for vertebrate Z-discs. (1998) (152)
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy (2007) (148)
Passive tension and stiffness of vertebrate skeletal and insect flight muscles: the contribution of weak cross-bridges and elastic filaments. (1993) (140)
Molecular Mechanics of Cardiac Titin's PEVK and N2B Spring Elements* (2002) (137)
Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency. (2009) (136)
The mechanically active domain of titin in cardiac muscle. (1995) (129)
Titin Isoform Variance and Length Dependence of Activation in Skinned Bovine Cardiac Muscle (2003) (128)
Calcium‐dependent inhibition of in vitro thin‐filament motility by native titin (1996) (125)
Structure–function relations of the giant elastic protein titin in striated and smooth muscle cells (2007) (124)
Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. (2013) (123)
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. (2012) (121)
Cardiac titin: structure, functions and role in disease. (2007) (119)
Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole (2014) (118)
Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction. (1997) (117)
The sensitive giant: the role of titin-based stretch sensing complexes in the heart. (2004) (116)
Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics. (1996) (115)
Cardiac Titin and Heart Disease (2014) (114)
Gel electrophoresis of giant proteins: Solubilization and silver‐staining of titin and nebulin from single muscle fiber segments (1993) (108)
Titin is a major human disease gene. (2013) (104)
A spring tale: new facts on titin elasticity. (1998) (104)
Effect of active pre‐shortening on isometric and isotonic performance of single frog muscle fibres. (1989) (104)
Physiological functions of the giant elastic protein titin in mammalian striated muscle. (2008) (100)
Truncation of Titin’s Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction (2009) (100)
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism (2018) (98)
A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics* (2012) (94)
Molecular dissection of N2B cardiac titin's extensibility. (1999) (94)
Effect of thin filament length on the force-sarcomere length relation of skeletal muscle. (1991) (93)
Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease. (2009) (91)
Tuning the molecular giant titin through phosphorylation: role in health and disease. (2013) (91)
Mechanical fatigue in repetitively stretched single molecules of titin. (2001) (90)
Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins. (2006) (90)
Transforming growth factor beta signaling in adult cardiovascular diseases and repair (2011) (90)
Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction (2016) (89)
Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice (2010) (89)
Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction (2013) (89)
Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension. (1997) (88)
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling. (2004) (88)
Structural and functional studies of titin's fn3 modules reveal conserved surface patterns and binding to myosin S1--a possible role in the Frank-Starling mechanism of the heart. (2001) (87)
Interplay between passive tension and strong and weak binding cross- bridges in insect indirect flight muscle. A functional dissection by gelsolin-mediated thin filament removal (1993) (87)
Titin and its associated proteins: the third myofilament system of the sarcomere. (2005) (87)
Titin and diaphragm dysfunction in chronic obstructive pulmonary disease. (2006) (86)
Extensibility of isoforms of cardiac titin: variation in contour length of molecular subsegments provides a basis for cellular passive stiffness diversity. (2000) (86)
Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently. (2001) (85)
MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. (2010) (85)
Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments. (2002) (84)
Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2). (2010) (83)
Titin: Physiological Function and Role in Cardiomyopathy and Failure (2005) (82)
Titin/connectin-based modulation of the Frank-Starling mechanism of the heart (2006) (82)
Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy (2006) (78)
Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations. (2012) (78)
A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies (2016) (77)
Complete unfolding of the titin molecule under external force. (1998) (76)
Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells (2011) (76)
Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle (2005) (74)
Nebulin, a major player in muscle health and disease (2011) (74)
The Giant Muscle Protein Titin is an Adjustable Molecular Spring (2006) (74)
Acidic and basic troponin T isoforms in mature fast-twitch skeletal muscle and effect on contractility. (1999) (72)
PEVK extension of human soleus muscle titin revealed by immunolabeling with the anti-titin antibody 9D10. (1998) (71)
Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle. (2011) (71)
Cardiac Hypertrophy and Reduced Contractility in Hearts Deficient in the Titin Kinase Region (2007) (70)
Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function (2014) (70)
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality (2015) (69)
Hyperphosphorylation of Mouse Cardiac Titin Contributes to Transverse Aortic Constriction-Induced Diastolic Dysfunction (2011) (69)
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements. (2013) (68)
Role of Titin Missense Variants in Dilated Cardiomyopathy (2015) (68)
Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles. (2011) (68)
Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. (2011) (66)
Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tension. (2011) (66)
Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin‐free skeletal muscle (2008) (65)
Tuning passive mechanics through differential splicing of titin during skeletal muscle development. (2009) (65)
Mechanics and structure of titin oligomers explored with atomic force microscopy. (2003) (63)
The descending limb of the force‐sarcomere length relation of the frog revisited. (1990) (63)
The giant protein titin regulates the length of the striated muscle thick filament (2017) (61)
Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance. (2007) (61)
Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle (2010) (60)
Tissue Triage and Freezing for Models of Skeletal Muscle Disease (2014) (59)
Hierarchical extensibility in the PEVK domain of skeletal-muscle titin. (2005) (57)
Dimerization of the cardiac ankyrin protein CARP: Implications for MARP titin-based signaling (2006) (57)
Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension (2014) (56)
A comparative proteome analysis of human metaphase chromosomes isolated from two different cell lines reveals a set of conserved chromosome‐associated proteins (2007) (56)
Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy (2011) (55)
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy (2018) (53)
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy. (2015) (52)
Selective Diaphragm Muscle Weakness After Contractile Inactivity During Thoracic Surgery (2011) (51)
Sarcomere dynamics during isotonic velocity transients in single frog muscle fibers. (1990) (51)
The Sarcomeric Protein Nebulin: Another Multifunctional Giant in Charge of Muscle Strength Optimization (2012) (50)
Titin isoform-dependent effect of calcium on passive myocardial tension. (2004) (49)
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice. (2010) (49)
Single Molecule Force Spectroscopy of the Cardiac Titin N2B Element (2009) (48)
Chymase Inhibition Prevents Fibronectin and Myofibrillar Loss and Improves Cardiomyocyte Function and LV Torsion Angle in Dogs With Isolated Mitral Regurgitation (2010) (48)
Positive End‐Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers (2018) (48)
Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness. (2010) (48)
Mutation‐specific effects on thin filament length in thin filament myopathy (2016) (47)
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations (2013) (47)
Elastic properties of single titin molecules made visible through fluorescent F-actin binding. (1996) (46)
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice (2020) (46)
Role of the giant elastic protein titin in the Frank-Starling mechanism of the heart. (2004) (45)
Molecular basis of passive stress relaxation in human soleus fibers: assessment of the role of immunoglobulin-like domain unfolding. (2003) (45)
Muscle atrophy in Titin M-line deficient mice (2006) (43)
MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodeling. (2020) (42)
Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling. (2015) (42)
Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears. (2008) (41)
The effects of PKCalpha phosphorylation on the extensibility of titin's PEVK element. (2010) (41)
Mechanical properties of titin isoforms. (2000) (41)
Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy (2013) (40)
Titin isoform expression in aortic stenosis. (2009) (40)
Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice. (2014) (38)
The effect of genetically expressed cardiac titin fragments on in vitro actin motility. (1995) (38)
Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac Disease Mechanism* (2013) (38)
Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle (2018) (37)
Cellular and molecular mechanisms of systolic and diastolic dysfunction in an avian model of dilated cardiomyopathy. (2004) (37)
Altered contractility of skeletal muscle in mice deficient in titin's M-band region. (2009) (36)
Myosin Cross-Bridge Dynamics in Patients With Hypertension and Concentric Left Ventricular Remodeling (2012) (36)
Thick-Filament Extensibility in Intact Skeletal Muscle. (2018) (36)
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease (2017) (35)
Role of titin in skeletal muscle function and disease. (2010) (35)
Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy (2016) (35)
Titin and diaphragm dysfunction in mechanically ventilated rats (2012) (34)
Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development. (2010) (34)
Titin: an endosarcomeric protein that modulates myocardial stiffness in DCM. (2002) (34)
Titin-Actin Interaction: PEVK-Actin-Based Viscosity in a Large Animal (2011) (32)
Titin‐based mechanosensing modulates muscle hypertrophy (2018) (31)
Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology. (2002) (31)
Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions. (2011) (31)
Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force. (2015) (30)
Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading? (2011) (30)
Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway. (2019) (30)
Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance (2018) (29)
Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle. (2007) (29)
Titin-Isoform Dependence of Titin-Actin Interaction and Its Regulation by S100A1/Ca2+ in Skinned Myocardium (2010) (29)
Removal of immunoglobulin-like domains from titin’s spring segment alters titin splicing in mouse skeletal muscle and causes myopathy (2014) (29)
Effect of diastolic pressure on MLC2v phosphorylation in the rat left ventricle. (2006) (29)
Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome. (2012) (28)
Sarcomere length dependence of the force-velocity relation in single frog muscle fibers. (1989) (28)
Lifting the nebula: novel insights into skeletal muscle contractility. (2010) (28)
Fine mapping titin's C-zone: Matching cardiac myosin-binding protein C stripes with titin's super-repeats. (2019) (28)
Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle. (2011) (28)
Titin mutations and muscle disease (2019) (27)
Exposure to Low-Dose Trichloroethylene Alters Shear Stress Gene Expression and Function in the Developing Chick Heart (2010) (27)
Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity (2019) (27)
Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn). (2016) (27)
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes (2019) (26)
New Insights into the Structural Roles of Nebulin in Skeletal Muscle (2010) (26)
Molecular tools for the study of titin's differential expression. (2000) (26)
Heart failure decreases passive tension generation of rat diaphragm fibers. (2010) (25)
Expression of titin isoforms in red and white muscle fibres of carp (Cyprinus carpio L.) exposed to different sarcomere strains during swimming (1997) (25)
Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin. (2016) (25)
Stepwise shortening in unstimulated frog skeletal muscle fibres. (1985) (24)
Mechanical manipulation of single titin molecules with laser tweezers. (2000) (23)
Renin Overexpression Leads to Increased Titin‐Based Stiffness Contributing to Diastolic Dysfunction in Hypertensive mRen2 Rats (2016) (23)
Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships. (2008) (22)
Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene (2015) (21)
Contemporary Reviews in Cardiovascular Medicine (2010) (20)
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice. (2013) (20)
CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. (2012) (19)
Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction. (2017) (19)
Activation and stretch-induced passive force enhancement--are you pulling my chain? Focus on "Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction". (2010) (19)
KBTBD13 is an actin-binding protein that modulates muscle kinetics. (2020) (19)
A comparison of quantitative ultrastructural and contractile characteristics of muscle fibre types of the perch,Perca fluviatilis L. (2004) (19)
New insights in the role of cardiac myosin binding protein C as a regulator of cardiac contractility. (2006) (18)
Reduced passive force in skeletal muscles lacking protein arginylation. (2016) (18)
Section: The Elastic Vertebrate Muscle Protein Titin; Titin as a modular spring: emerging mechanisms for elasticity control by titinin cardiac physiology and pathophysiology (2002) (18)
Nebulin increases thin filament stiffness and force per cross-bridge in slow-twitch soleus muscle fibers (2018) (18)
Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction (2020) (17)
Elastic Filaments of the Cell (2000) (17)
Contractile properties of a white- and a red-fibre type of the m. hyohyoideus of the carp (Cyprinus carpio L.) (1983) (17)
Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP (2020) (16)
Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy (2016) (14)
Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm20ΔRRM Mice (2016) (13)
From connecting filaments to co-expression of titin isoforms. (2000) (13)
Advances in Muscle Physiology and Pathophysiology (2010) (13)
Sarcomere length–dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin (2018) (13)
Diaphragm contractile weakness due to altered mechanical loading: role of titin. (2019) (12)
Novex-3, the tiny titin of muscle (2017) (12)
Dynamic myocardial contractile parameters from left ventricular pressure-volume measurements. (2005) (12)
Deleting nebulin's C-terminus reveals its importance to sarcomeric structure and function and is sufficient to invoke nemaline myopathy. (2019) (12)
Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia (2020) (12)
Extensible Behavior of Titin in the Miniswine Left Ventricle (2010) (12)
Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy (2019) (11)
Muscular changes in animal models of heart failure with preserved ejection fraction: what comes closest to the patient? (2020) (11)
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator (2021) (11)
Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium. (2021) (10)
Journal of Muscle Research and Cell Motility: Preface (2002) (10)
Myosin light chain phosphorylation to the rescue (2015) (9)
Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy (2017) (9)
Differences in I band structure, sarcomere extensibility and electrophoresis of titin between two muscle fiber types of the perch (Perca fluviatilis L.). (1989) (9)
Myostatin Inhibition Using ActRIIB-mFc Does Not Produce Weight Gain or Strength in the Nebulin Conditional KO Mouse (2018) (8)
Acidic and basic troponin T isoforms in mature fast-twitch skeletal muscle and effect on contractility. (1999) (7)
Protein Kinase A Phosphorylates Cardiac-Specific N 2 B Domain of Titin and Reduces Passive Tension in Rat Cardiac Myocytes (2002) (7)
Adaptations in titin's spring elements in normal and cardiomyopathic hearts. (2003) (7)
Deleting Titin’s C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle (2020) (6)
Mechanics of Elastic Biomolecules (2012) (6)
Pauses, steps, and the mechanism of contraction. (1988) (6)
Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice. (2016) (6)
Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics (2014) (6)
The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size (2020) (6)
Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy (2019) (6)
Downsizing the Giant Titin Reveals its Dominant Roles in Skeletal Muscle Passive Stiffness and Longitudinal Hypertrophy (2019) (5)
HDAC6 modulates myofibril stiffness and diastolic function of the heart (2022) (5)
Variable titin-based stiffness adjustment in heart disease. (2003) (5)
Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease (2018) (5)
Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator tirasemtiv (2019) (4)
Stepwise shortening of muscle fibre segments (1987) (4)
RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis (2022) (4)
The cytoskeleton and the cellular transduction of mechanical strain in the heart: a special issue (2011) (4)
The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II Delta (CaMKIIδ) Phosphorylates Titin N2B and PEVK Spring Elements (2012) (4)
Advances in Muscle Physiology and Pathophysiology 2011 (2012) (4)
Softening the Stressed Giant Titin in Diabetes Mellitus. (2018) (4)
Contributions of Titin and Collagen to Passive Stress in Muscles from mdm Mice with a Small Deletion in Titin’s Molecular Spring (2022) (3)
Editorial: Recent Advances on Myocardium Physiology (2021) (3)
NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy (2022) (3)
A Spring Tale: New Facts on (1998) (2)
In vivo characterization of skeletal muscle function in nebulin‐deficient mice (2019) (2)
Experimentally Increasing Titin’s Compliance Through RBM20 Inhibition Improves Diastolic Function in a Mouse Model of HFpEF (2016) (2)
Progress on the regulation of myofibrillar function: Part 2 (2019) (2)
Nebulin Stiffens the Thin Filament and Augments Crossbridge Interaction - An X-Ray Diffraction Study on Intact Muscle (2018) (2)
Reply to Tskhovrebova et al.: Titin’s IA junction does not control thick filament length (2015) (2)
Thin Filament Length in Mouse Skeletal Muscle and its Relationship to Differential Splicing of Nebulin (2011) (2)
Cardiomyocyte stretch-sensing (2011) (2)
Muscle fibre types and muscle function in fish (1985) (2)
Response to: Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components. (2019) (2)
Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy (2016) (1)
Further progress in understanding of myofibrillar function in health and disease (2021) (1)
Toward an understanding of myofibrillar function in health and disease (2021) (1)
Titin-IsoformDependence of Titin-Actin Interaction and Its Regulation by S 100 A 1 / Ca 2 + in SkinnedMyocardium (2014) (1)
Matrix Metalloproteinase Inhibitors Attenuate Doxorubicin‐Induced Heart Failure by Preventing Cardiac Titin Proteolysis (2018) (1)
Titin Gene (TTN): Description of the Gene Coding for Titin, a Giant Protein of Critical Importance for Myofibrillar Integrity and Elasticity in Vertebrate Striated Muscle (2018) (1)
Titin M-Line insertion sequence 7 is required for proper cardiac function in mice. (2021) (1)
Shortening of Titin’s Elastic Tandem Ig Segment Leads to Diastolic Dysfunction (2013) (1)
Titin Gene (TTN) (2011) (1)
Mouse Intact and Skinned Cardiac Myocyte Mechanics: Crossbridge and Titin-Based Stress in Unactivated Cells (2011) (1)
Author response: Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy (2018) (1)
A Direct Method to Measure the Restoring Force and Slack Sarcomere Length of Intact Cardiomyocytes (2009) (1)
Increased Expression of N2BA Titin Corresponds to More Compliant Myofibrils in Athlete’s Heart (2021) (1)
A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death (2019) (0)
Titin Isoform Transitions and Passive Stiffness During Skeletal Muscle Development (2009) (0)
A New Mouse Model in which the Proximal Tandem Ig Element of Titin is Truncated (IGKO) - Assessment of Diastolic Function (2012) (0)
Titin (ITN) mutations in dilated cardiomyopathy: Evidence for cardiac but not skeletal muscle haploinsufficiency in a I-Band truncation mutation and further genetic (Allelic and non-allelic) heterogeneity (2003) (0)
Single Molecule Studies of a Titin Mutation Linked to Cardiac Disease (2012) (0)
Abstract 375: Mechanotransduction via Titin’s N2B Element Contributes to Cardiac Remodeling (2015) (0)
Comparison of Human and Mouse Recombinant Titin N2B Fragment as a Substrate for PKA and PKG (2011) (0)
Sarcomere Lengthdependent Effects on the Ca2+-Troponin Regulation in Skinned Myocardial Fiber from Titin RBM20 Deletion Mice (2017) (0)
Passive Viscosity Decreases with Deletion of PEVK Region of Cardiac Titin (2013) (0)
Titin mutations in familial dilated cardiomyopathy (2001) (0)
Removal of Ig Domains of Titin Alters Contractility in Mouse Soleus Muscle (2012) (0)
Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF) (2022) (0)
Titin mutations and muscle disease (2019) (0)
Catch a Tiny Fish by the Tail. (2020) (0)
Abstract 76: Experimentally Increasing Titin’s Compliance in a Mouse Model of Heart Failure with Preserved Ejection Fraction Ameliorates Diastolic Dysfunction (2016) (0)
Characterization of Titin Following Transverse Aortic Constriction in Mice (2011) (0)
Characterization of a Kbtbd13‐Deficient Mouse Model That Recapitulates Nemaline Myopathy With Mutations in The KBTBD13 Gene (2015) (0)
Volume Overload Heart Failure Increases Myocardiac Passive Stiffness in a Mouse Model (2013) (0)
KBTBD13 is a novel cardiomyopathy gene (2022) (0)
Abstract 440: The Cardiomyocyte Diastolic Stiffness and Contractility are Inversely Related to the Size of Titin: A Cellular Work Loop Study of Single Intact Cardiomyocytes (2018) (0)
Response by Methawasin and Granzier to Letter Regarding Article, "Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction". (2017) (0)
The Dystrophin Glycoprotein Complex: Structure and Function in Cardiac and Skeletal Muscle Cardiac Myosin Binding Protein C: Its Role in Physiology and Disease (2004) (0)
Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function (2020) (0)
rBM 20 ) inhibition improves Diastolic Function in a Mouse Model of heart Failure With Preserved ejection Fraction (2016) (0)
Abstract 17211: Titin Mutations Cause Arrhythmogenic Right Ventricular Cardiomyopathy (2010) (0)
Experimentally Varying the Number of Super-Repeats in the Neb Gene of the Mouse - Assessing the Role of Nebulin in Thin Filament Length Regulation (2019) (0)
Ultrastructure of fish muscle fibre types with different contractile properties. (1986) (0)
Stepwise shortening and the mechanism of contraction (1987) (0)
Titin and its associated proteins: integrating structure, mechanics, and signal transduction pathways (2006) (0)
Transforming growth factor beta signaling in adult cardiovascular diseases and repair (2011) (0)
Mutations in the Large Protein Nebulin Trigger Typical Nemaline Myopathy with a Unique Molecular Mechanism (2020) (0)
Single Molecule Analysis of PKC Phosphorylation of Titin's PEVK Domain (2010) (0)
Alterations in Cardiac Myocyte Cytoskeleton (2005) (0)
The Giant Elastic Protein Titin Role in Muscle Function and Disease (2010) (0)
Effect of Shortening Titin's Proximal IG Segment on Passive Cellular Mechanics (2012) (0)
Length Dependence of Activation (LDA) Studies in Mice Deficient in the N2B Element of Titin (2011) (0)
Abstract 336: The Effect Of Phosphodiesterase 9a Inhibition In 2 Mouse Models Of Diastolic Dysfunction (2019) (0)
New and Notable Catch a Tiny Fish by the Tail (2020) (0)
Abstract 532: Titin’s N2B Element is Critical to Cardiac Mechanotransduction during Volume Overload, but not Pressure Overload (2018) (0)
Editorial: Recent Advances on Myocardium Physiology, Volume II (2023) (0)
Developmentally Regulated Differential Splicing of the Large Sarcomeric Proteins Titin and Nebulin (2010) (0)
Abstract 20441: Mechanism of Mechanical Stress-Regulated Non-Muscle Myosin Light Chain Kinase Alternative Splicing, Implication for Acute Lung Inflammation (2014) (0)
Actin Motility (2005) (0)
1P235 Single molecule measurement of Elasticity of connectin-like 1200K-protein in obliquely striated muscle of a polychaete (Annelida)(8. Muscle contraction and muscle protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
Shortening of Titin's Elastic Tandem Ig Segment Leads to Cardiac Hypertrophy and Diastolic Dysfunction (2013) (0)
Passive Properties of the Isolated Mouse Heart: Titin, Collagen and the Working Sarcomere Length Range (2011) (0)
Response by Methawasin and Granzier to Letter Regarding Article, "Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction". (2021) (0)
The Role of Titin's N2B Element in Limiting Energy Loss of Mouse Myocardium During Repeated Loading Cycles (2011) (0)
Exercise Mitigates Increased Diastolic Stiffness in the Titin IA KO Mouse (2016) (0)
Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy (2022) (0)
Force-Sarcomere Length Relations in Patients with Thin Filament Myopathy Caused by Mutations in NEB, ACTA1, TPM2, TPM3, KBTBD13, KLHL40 and KLHL41 (2015) (0)
Altered Cross Bridge Kinetics in Skeletal Myofibrils from NEBΔex55, a Novel Mouse Model of Nebulin-Based Nemaline Myopathy (2013) (0)
Abstract P315: Shortening The Thick Filament By Partial Deletion Of Titin’S C-zone Alters Cardiac Function By Reducing The Operating Sarcomere Length Range Of The Heart. (2021) (0)
1P173 Single molecule measurement of elasticity of connectin-like 1200K-protein fragment B in a polychaete (Annelida)(Muscle-muscle proteins and contraction,Poster Presentations) (2007) (0)
Contrasting Modes ofRecognition of Bacterial Signal Sequences by Proteins and Membranes (2005) (0)
Molecules Characterized with Laser Tweezers Folding-Unfolding Transitions in Single Titin (2008) (0)
diomyocyte stiffness as a consequence to functional modifications of the sarcomeric protein titin. By folding during contraction and stretching during relaxation, titin (2017) (0)
Importance of Titin Based Viscosity in Cardiac Function: an Integrative Study on PEVK-Actin Interactions (2010) (0)
Novel Insights in the Function of the Giant Sarcomeric Proteins Titin and Nebulin (2011) (0)
Quantification of Titin Based Viscosity: Temperature, Lattice Compression and Integrative Physiology (2011) (0)
Removal of Proximal IG Domains of Titin in Soleus Muscle Results in Differential Splicing of Titin MRNA (2013) (0)
Novex-3, the tiny titin of muscle (2017) (0)
Titin-Based Passive Tension is Increased in a Titin AI KO Mouse (2014) (0)
Appearance of Local Abnormalities of Left Ventricular Contraction on Top of Global Diastolic Dysfunction in the Hypertensive mRen2 Rat (2017) (0)
Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac (2013) (0)
Syndromestiffening of muscle fibers in Ehlers-Danlos (2015) (0)
Shortening the thick filament by partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range (2022) (0)
Increased Ca2+ Sensitivity and Length Dependent Activation in a Mouse Model with Increased Titin-Based Stiffness (2010) (0)
The giant protein titin regulates the length of the striated muscle thick filament (2017) (0)
Rbm20ΔRRM Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness (2022) (0)
Titin (TTN) Gene (2005) (0)
Thick Filament Compliance in Passively Stretched Skeletal Muscle (2017) (0)
A Novel Mouse Model for Titin-Based Dilated Cardiomyopathy (2018) (0)
A Novel Mouse Model of Nebulin-Based Nemaline Myopathy (2013) (0)
Abstract 768: Diastolic Sarcomere Lengths in the Left Ventricle: Implications for Titin-Based Myocardial Stiffness (2006) (0)
Abstract 215: The Role of Titin in Cardiac Function: Studies in Two Genetically Engineered Mouse Models With Disparate Titin’s Size (2015) (0)
Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy (2016) (0)
Monday , February 22 , 2010 415 a 2141-Plat Troponin Regulatory Function and Dynamics Revealed by H / D Exchange-Mass Spectrometry (0)
Matrix metalloproteinase‐2 co‐localizes with titin in cardiac myocytes and contributes to its proteolysis in ischemia‐reperfusion injury (2009) (0)
Determining the Molecular Mechanisms that Link a Titin Mutation to Cardiomyopathy (2014) (0)
pressure-volume relationships ventricular integrating cardiac muscle contraction into Dynamic left ventricular elastance: a model for (2015) (0)
Effect of Excision of Titin's PEVK Exons 219-225 on Skeletal Muscle Structure and Function (2010) (0)
The N2B Element of Cardiac Titin Greatly Reduces Energy Loss During Loading Cycles of the Heart (2010) (0)
Abstract 903: Rapamycin Treatment Reduces Myocardial Stiffness and Promotes Cardiomyocyte Relaxation to Restore Diastolic Function in Old Murine Hearts (2019) (0)
Upregulating Compliant Titin in the Heart Attenuates Left Ventricular Stiffness in a Mouse Model with Diastolic Dysfunction (2016) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Henk L. M. Granzier?

Henk L. M. Granzier is affiliated with the following schools:

Washington State University
University of Alberta
University of Arizona
University of Oregon
University of Washington
University of Bonn