Herbert W. Virgin
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Biology Philosophy
Herbert W. Virgin's Degrees
- Doctorate Medicine University of California, San Francisco
- PhD Microbiology University of California, San Francisco
Why Is Herbert W. Virgin Influential?
(Suggest an Edit or Addition)According to Wikipedia, Herbert W. "Skip" Virgin was the Edward Mallinckrodt Professor and Chair of the Department of Pathology & Immunology at the Washington University School of Medicine and a member of the National Academy of Sciences. He is best known for establishing murine norovirus as a model system for studying norovirus biology, for identifying host phenotypes associated with persistent viral infections, for defining alterations to the human virome in the context of different diseases, and for elucidating the roles of autophagy and interferon-stimulated genes during viral infection.
Herbert W. Virgin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
- Autophagy in immunity and inflammation (2011) (2794)
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 (2015) (2537)
- Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody (2020) (1411)
- Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis (2012) (980)
- Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology (2020) (957)
- Redefining Chronic Viral Infection (2009) (908)
- Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease (2015) (878)
- Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine (2010) (840)
- Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages (2004) (803)
- Complete sequence and genomic analysis of murine gammaherpesvirus 68 (1997) (784)
- STAT1-Dependent Innate Immunity to a Norwalk-Like Virus (2003) (780)
- Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity (2013) (758)
- Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway (2001) (745)
- Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies (2021) (702)
- Herpesvirus latency confers symbiotic protection from bacterial infection (2007) (673)
- Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift (2021) (670)
- Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins (2015) (641)
- TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease (2017) (610)
- Murine Norovirus: a Model System To Study Norovirus Biology and Pathogenesis (2006) (566)
- Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies (2021) (562)
- IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses (2007) (518)
- Autophagy links inflammasomes to atherosclerotic progression. (2012) (490)
- Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. (2015) (473)
- The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. (2015) (462)
- The Virome in Mammalian Physiology and Disease (2014) (459)
- Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity (2021) (443)
- Autophagy genes in immunity (2009) (433)
- Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms (2020) (427)
- Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease (2016) (418)
- Lactobacillus‐Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women (2017) (417)
- Identification of a candidate therapeutic autophagy-inducing peptide (2013) (417)
- Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens (2008) (411)
- Autophagy proteins regulate the secretory component of osteoclastic bone resorption. (2011) (393)
- A perspective on potential antibody-dependent enhancement of SARS-CoV-2 (2020) (378)
- Biologic consequences of Stat1-independent IFN signaling (2001) (376)
- Immunodeficiency, auto-inflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency (2012) (372)
- Interferons Regulate the Phenotype of Wild-type and Mutant Herpes Simplex Viruses In Vivo (1999) (364)
- N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 (2021) (358)
- Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses (2007) (352)
- Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection (2015) (349)
- Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells (2016) (340)
- Macrophages Are the Major Reservoir of Latent Murine Gammaherpesvirus 68 in Peritoneal Cells (1999) (327)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
- Autophagy is essential for effector CD8 T cell survival and memory formation (2014) (321)
- N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 (2021) (314)
- Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense (2014) (298)
- Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity (2015) (293)
- Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement (2021) (292)
- Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. (2010) (291)
- Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. (2016) (284)
- SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern (2021) (283)
- IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling (2013) (280)
- Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo (2005) (278)
- Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys (2015) (275)
- Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. (2012) (270)
- Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. (2000) (261)
- Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome (2012) (257)
- SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape (2021) (251)
- Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing) (1988) (242)
- Gut DNA viromes of Malawian twins discordant for severe acute malnutrition (2015) (239)
- Murine Noroviruses Comprising a Single Genogroup Exhibit Biological Diversity despite Limited Sequence Divergence (2007) (236)
- Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation (2014) (230)
- Interferon-Inducible Ubiquitin E2, Ubc8, Is a Conjugating Enzyme for Protein ISGylation (2004) (220)
- Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. (2005) (217)
- Discovery of a proteinaceous cellular receptor for a norovirus (2016) (217)
- Autophagy proteins control goblet cell function by potentiating reactive oxygen species production (2013) (213)
- Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma (2012) (213)
- Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. (2013) (210)
- Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children (2017) (206)
- Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes (2009) (205)
- Identification of a Novel Astrovirus (Astrovirus VA1) Associated with an Outbreak of Acute Gastroenteritis (2009) (205)
- Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2 (2020) (204)
- Metagenomics and Personalized Medicine (2011) (201)
- B Cells Regulate Murine Gammaherpesvirus 68 Latency (1999) (200)
- Unique role for ATG5 in PMN-mediated immunopathology during M. tuberculosis infection (2015) (198)
- After the pandemic: perspectives on the future trajectory of COVID-19 (2021) (197)
- Coronavirus Replication Does Not Require the Autophagy Gene ATG5 (2007) (193)
- The T-cell-independent role of gamma interferon and tumor necrosis factor alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infections (1995) (193)
- Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells (2006) (192)
- Immunology and the elusive AIDS vaccine (2010) (191)
- Accounting for reciprocal host–microbiome interactions in experimental science (2016) (189)
- Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2. (2020) (182)
- Validation of a next-generation sequencing assay for clinical molecular oncology. (2014) (180)
- Advances in norovirus biology. (2014) (179)
- Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action (2000) (176)
- Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response. (2016) (174)
- Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier (2004) (174)
- Broad betacoronavirus neutralization by a stem helix–specific human antibody (2021) (173)
- Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation (2014) (172)
- Natural Killer Cells Utilize both Perforin and Gamma Interferon To Regulate Murine Cytomegalovirus Infection in the Spleen and Liver (2005) (171)
- Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter (2014) (170)
- Murine γ-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: A new model for virus-induced vascular disease (1997) (170)
- Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis (2012) (165)
- Three Distinct Regions of the Murine Gammaherpesvirus 68 Genome Are Transcriptionally Active in Latently Infected Mice (1999) (165)
- Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii (2013) (164)
- The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. (2014) (163)
- Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies (2021) (159)
- The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2 (2022) (157)
- Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift (2021) (157)
- Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action (1991) (157)
- FIP200 regulates targeting of Atg16L1 to the isolation membrane (2013) (157)
- 2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo (2012) (156)
- Tropism for tuft cells determines immune promotion of norovirus pathogenesis (2018) (155)
- Transkingdom control of viral infection and immunity in the mammalian intestine (2016) (154)
- Broad sarbecovirus neutralization by a human monoclonal antibody (2021) (153)
- WDFY4 is required for cross-presentation in response to viral and tumor antigens (2018) (152)
- Kingdom-Agnostic Metagenomics and the Importance of Complete Characterization of Enteric Microbial Communities (2014) (150)
- Vertically transmitted fecal IgA levels distinguish extra-chromosomal phenotypic variation (2014) (147)
- Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis (2016) (142)
- Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. (2007) (142)
- Virus subversion of the MHC class I peptide-loading complex. (2003) (141)
- Latent murine cytomegalovirus infection in macrophages. (1997) (140)
- The Interferon-Inducible Gene viperin Restricts West Nile Virus Pathogenesis (2011) (139)
- The Murine Gammaherpesvirus 68 v-Cyclin Is a Critical Regulator of Reactivation from Latency (2000) (137)
- Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection. (1999) (137)
- Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease. (1997) (134)
- Identification of the In Vivo Role of a Viral bcl-2 (2002) (129)
- SARS-CoV-2 immune evasion by variant B.1.427/B.1.429 (2021) (128)
- ATG5 regulates plasma cell differentiation (2013) (127)
- Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis. (1999) (127)
- Latency, without persistence, of murine cytomegalovirus in the spleen and kidney (1995) (126)
- Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus (2002) (123)
- A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells (2015) (121)
- Reservoir Host Immune Responses to Emerging Zoonotic Viruses (2014) (121)
- Establishment and Maintenance of Gammaherpesvirus Latency Are Independent of Infective Dose and Route of Infection (2003) (118)
- Mouse Norovirus Replication Is Associated with Virus-Induced Vesicle Clusters Originating from Membranes Derived from the Secretory Pathway (2009) (116)
- Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus (2017) (116)
- Immune Control of the Number and Reactivation Phenotype of Cells Latently Infected with a Gammaherpesvirus (2002) (114)
- Structural Basis of Chemokine Sequestration by a Herpesvirus Decoy Receptor (2002) (113)
- A Single-Amino-Acid Change in Murine Norovirus NS1/2 Is Sufficient for Colonic Tropism and Persistence (2012) (112)
- Structural and functional analysis of a potent sarbecovirus neutralizing antibody (2020) (112)
- Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection (2008) (110)
- Disruption of the Murine Gammaherpesvirus 68 M1 Open Reading Frame Leads to Enhanced Reactivation from Latency (2000) (110)
- Disruption of the M2 Gene of Murine Gammaherpesvirus 68 Alters Splenic Latency following Intranasal, but Not Intraperitoneal, Inoculation (2002) (110)
- Recovery of infectious murine norovirus using pol II-driven expression of full-length cDNA (2007) (109)
- The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity (2020) (103)
- Replication of Murine Cytomegalovirus in Differentiated Macrophages as a Determinant of Viral Pathogenesis (1999) (101)
- Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2 (2020) (101)
- MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes (2016) (100)
- Listeriolysin O Is Necessary and Sufficient to Induce Autophagy during Listeria monocytogenes Infection (2010) (98)
- Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis. (2002) (96)
- Murine Gammaherpesvirus 68 Infection Is Associated with Lymphoproliferative Disease and Lymphoma in BALB β2 Microglobulin-Deficient Mice (2005) (96)
- Antibody Is Critical for the Clearance of Murine Norovirus Infection (2008) (96)
- Structure of Antibody-Neutralized Murine Norovirus and Unexpected Differences from Viruslike Particles (2007) (95)
- Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. (2020) (95)
- Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo (2012) (95)
- IFN-γ action in the media of the great elastic arteries, a novel immunoprivileged site (2001) (93)
- Characterization of Gammaherpesvirus 68 Gene 50 Transcription (2000) (92)
- VirusSeeker, a computational pipeline for virus discovery and virome composition analysis. (2017) (91)
- Alpha/Beta Interferons Regulate Murine Gammaherpesvirus Latent Gene Expression and Reactivation from Latency (2005) (90)
- Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency (2006) (89)
- Identification of Novel MicroRNA-Like Molecules Generated from Herpesvirus and Host tRNA Transcripts (2010) (88)
- Protruding Domain of Capsid Protein Is Necessary and Sufficient To Determine Murine Norovirus Replication and Pathogenesis In Vivo (2012) (87)
- Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection. (2002) (86)
- Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication (2012) (86)
- Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections (2018) (85)
- ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus (2008) (85)
- Solution structure of the BHRF1 protein from Epstein-Barr virus, a homolog of human Bcl-2. (2003) (84)
- Murine Gammaherpesvirus 68 Encodes a Functional Regulator of Complement Activation (1999) (84)
- Early B-Cell Activation after West Nile Virus Infection Requires Alpha/Beta Interferon but Not Antigen Receptor Signaling (2008) (83)
- Spliced mRNA Encoding the Murine Cytomegalovirus Chemokine Homolog Predicts a β Chemokine of Novel Structure (1999) (83)
- Identification and Initial Characterization of the Murine Gammaherpesvirus 68 Gene M3, Encoding an Abundantly Secreted Protein (1999) (82)
- Late expression of a beta chemokine homolog by murine cytomegalovirus (1997) (82)
- Quaranfil, Johnston Atoll, and Lake Chad Viruses Are Novel Members of the Family Orthomyxoviridae (2009) (81)
- Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. (2016) (79)
- Persistent Enteric Murine Norovirus Infection Is Associated with Functionally Suboptimal Virus-Specific CD8 T Cell Responses (2013) (79)
- Effective Vaccination against Long-Term Gammaherpesvirus Latency (2003) (79)
- Relationship of macrophage Ia and membrane IL 1 expression to antigen presentation. (1985) (78)
- An Optimized CD8+ T-Cell Response Controls Productive and Latent Gammaherpesvirus Infection (2004) (78)
- High-Resolution Cryo-Electron Microscopy Structures of Murine Norovirus 1 and Rabbit Hemorrhagic Disease Virus Reveal Marked Flexibility in the Receptor Binding Domains (2010) (78)
- Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway (2012) (77)
- Antibody to a Lytic Cycle Viral Protein Decreases Gammaherpesvirus Latency in B-Cell-Deficient Mice (2002) (76)
- Novel Cell Type–Specific Antiviral Mechanism of Interferon γ Action in Macrophages (2001) (76)
- Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection (2020) (76)
- Disruption of Gammaherpesvirus 68 Gene 50 Demonstrates that Rta Is Essential for Virus Replication (2003) (75)
- Identification of Novel Viruses Using VirusHunter -- an Automated Data Analysis Pipeline (2013) (73)
- Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis (1993) (72)
- SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination. (2016) (72)
- Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system (1989) (72)
- Type I interferons link viral infection to enhanced epithelial turnover and repair. (2015) (72)
- Lymphocytes protect against and are not required for reovirus-induced myocarditis (1993) (71)
- A Surface Groove Essential for Viral Bcl-2 Function During Chronic Infection In Vivo (2005) (71)
- SARS-CoV-2 variants show resistance to neutralization by many monoclonal and serum-derived polyclonal antibodies (2021) (71)
- SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies (2021) (70)
- Latent herpesvirus infection arms NK cells. (2010) (70)
- Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor (2018) (69)
- Predicting the mutational drivers of future SARS-CoV-2 variants of concern (2021) (69)
- The Francisella O‐antigen mediates survival in the macrophage cytosol via autophagy avoidance (2014) (68)
- Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains (2022) (66)
- IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site. (2001) (65)
- The Murine Gammaherpesvirus 68 v-Cyclin Gene Is an Oncogene That Promotes Cell Cycle Progression in Primary Lymphocytes (1999) (65)
- Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency in a Cell Type-Specific Manner (2007) (64)
- Adaptive Immunity Restricts Replication of Novel Murine Astroviruses (2012) (64)
- Ongoing Viral Replication Is Required for Gammaherpesvirus 68-Induced Vascular Damage (2000) (64)
- Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection (2014) (63)
- Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine. (2017) (63)
- In vivo and in vitro expression of macrophage membrane interleukin 1 in response to soluble and particulate stimuli. (1986) (60)
- A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica (1992) (60)
- Murine cytomegalovirus infection inhibits IFN gamma-induced MHC class II expression on macrophages: the role of type I interferon. (1998) (58)
- Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity (2016) (57)
- Characterization of a Spontaneous 9.5-Kilobase-Deletion Mutant of Murine Gammaherpesvirus 68 Reveals Tissue-Specific Genetic Requirements for Latency (2002) (56)
- Invariant NKT Cells Require Autophagy To Coordinate Proliferation and Survival Signals during Differentiation (2015) (56)
- Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages (2012) (55)
- Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation (2020) (55)
- Role of autophagy and autophagy genes in inflammatory bowel disease. (2009) (55)
- VIRAL CHEMOKINE-BINDING PROTEINS INHIBIT INFLAMMATORY RESPONSES AND AORTIC ALLOGRAFT TRANSPLANT VASCULOPATHY IN RAT MODELS (2004) (55)
- Impaired autophagy in macrophages promotes inflammatory eye disease (2016) (54)
- An Optimized CD4 T-Cell Response Can Control Productive and Latent Gammaherpesvirus Infection (2004) (52)
- Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation (2016) (52)
- Disruption of the gene encoding the gammaHV68 v-GPCR leads to decreased efficiency of reactivation from latency. (2003) (52)
- Immune complex effects on murine macrophages. I. Immune complexes suppress interferon-gamma induction of Ia expression. (1985) (51)
- The Murine Gammaherpesvirus 68 v-Cyclin Gene Is an Oncogene That Promotes Cell Cycle Progression in Primary Lymphocytes (1999) (50)
- Imprinted antibody responses against SARS-CoV-2 Omicron sublineages (2022) (50)
- Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry (2021) (49)
- Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes (1995) (49)
- Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue tropism (1996) (49)
- Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2 (2017) (49)
- A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. (2019) (47)
- Maintenance of Gammaherpesvirus Latency Requires Viral Cyclin in the Absence of B Lymphocytes (2003) (47)
- Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases (1994) (47)
- Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors (2014) (46)
- Detection of Novel Sequences Related to African Swine Fever Virus in Human Serum and Sewage (2009) (46)
- Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide (2016) (46)
- CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNγ (2005) (45)
- Mucosal and Parenteral Vaccination against Acute and Latent Murine Cytomegalovirus (MCMV) Infection by Using an Attenuated MCMV Mutant (1998) (43)
- Murine Gammaherpesvirus 68 Has Evolved Gamma Interferon and Stat1-Repressible Promoters for the Lytic Switch Gene 50 (2010) (42)
- Suppression of the immune response to Listeria monocytogenes. I. Immune complexes inhibit resistance. (1984) (41)
- Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry (2022) (41)
- Differentiation and Protective Capacity of Virus‐Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune‐Privileged Enteric Niche (2017) (39)
- Myxomavirus-Derived Serpin Prolongs Survival and Reduces Inflammation and Hemorrhage in an Unrelated Lethal Mouse Viral Infection (2013) (38)
- In vivo veritas: pathogenesis of infection as it actually happens (2007) (37)
- A gamma-herpesvirus deficient in replication establishes chronic infection in vivo and is impervious to restriction by adaptive immune cells. (2006) (37)
- Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies (2021) (37)
- Role of immune cells in protection against and control of reovirus infection in neonatal mice (1991) (36)
- Circulating immunoglobulin G can play a critical role in clearance of intestinal reovirus infection (1996) (36)
- SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies (2021) (36)
- Granzymes and Caspase 3 Play Important Roles in Control of Gammaherpesvirus Latency (2004) (35)
- Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening (2018) (35)
- Antibody-Independent Control of γ-Herpesvirus Latency via B Cell Induction of Anti-Viral T Cell Responses (2006) (34)
- Murine Cytomegalovirus Infection Inhibits Tumor Necrosis Factor Alpha Responses in Primary Macrophages (2003) (33)
- Redefining the genetics of murine gammaherpesvirus 68 via transcriptome-based annotation. (2010) (33)
- HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection (2018) (32)
- Critical Role of CD4 T Cells in an Antibody-Independent Mechanism of Vaccination against Gammaherpesvirus Latency (2004) (32)
- Pathogenesis of viral infection (2013) (32)
- Murine Gammaherpesvirus 68 Genes both Induce and Suppress Lymphoproliferative Disease (2007) (32)
- Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cell Attachment and Immune Evasion (2019) (31)
- Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape (2021) (30)
- Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection (2018) (29)
- Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock (2019) (29)
- Effective Control of Chronic γ-Herpesvirus Infection by Unconventional MHC Class Ia–Independent CD8 T Cells (2006) (29)
- Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody (2020) (29)
- Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) (29)
- The Genome of Yoka Poxvirus (2011) (29)
- Immune complex effects on murine macrophages. II. Immune complex effects on activated macrophages cytotoxicity, membrane IL 1, and antigen presentation. (1985) (27)
- Murine Norovirus Infection Has No Significant Effect on Adaptive Immunity to Vaccinia Virus or Influenza A Virus (2009) (26)
- Suppression of immune response to Listeria monocytogenes: mechanism(s) of immune complex suppression (1985) (26)
- Identification and Sequencing of a Novel Rodent Gammaherpesvirus That Establishes Acute and Latent Infection in Laboratory Mice (2011) (26)
- Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes (2019) (25)
- ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells (2020) (25)
- Rapid Cloning of Novel Rhesus Adenoviral Vaccine Vectors (2018) (24)
- Murine cytomegalovirus paralyzes macrophages by blocking IFNγ-induced promoter assembly (2003) (22)
- Histone Deacetylases and the Nuclear Receptor Corepressor Regulate Lytic-Latent Switch Gene 50 in Murine Gammaherpesvirus 68-Infected Macrophages (2010) (22)
- Membrane lectins enhance SARS-CoV-2 infection and influence the neutralizing activity of different classes of antibodies (2021) (22)
- Cellular and humoral immunity to reovirus infection. (1998) (22)
- CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgamma. (2005) (21)
- Clinical genomicist workstation. (2013) (21)
- Animal models of infection-mediated vasculitis. (1999) (20)
- Lrp1 is a host entry factor for Rift Valley fever virus (2021) (20)
- Imprinted antibody responses against SARS-CoV-2 Omicron sublineages (2022) (19)
- Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly. (2003) (19)
- Erratum: The murine gammaherpesvirus 68 v-cyclin gene is an oncogene that promotes cell cycle progression in primary lymphocytes (Journal of Virology (1999) 73:6 (5110-5122)) (1999) (18)
- Correction: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling (2013) (18)
- Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody (2021) (18)
- MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner. (2010) (18)
- Latent Gammaherpesvirus 68 Infection Induces Distinct Transcriptional Changes in Different Organs (2013) (18)
- Murine norovirus protein NS1/2 aspartate to glutamate mutation, sufficient for persistence, reorients side chain of surface exposed tryptophan within a novel structured domain (2014) (18)
- Animal models of infection-mediated vasculitis: implications for human disease. (2000) (17)
- Herpesvirus latency and symbiotic protection from bacterial infection. (2009) (17)
- Correction: MDA-5 Recognition of a Murine Norovirus (2008) (16)
- Advances in Genomics for Drug Development (2020) (16)
- "Next-generation" pathology and laboratory medicine. (2011) (16)
- Virome biogeography in the lower gastrointestinal tract of rhesus macaques with chronic diarrhea. (2019) (16)
- Pervasive Transcription of a Herpesvirus Genome Generates Functionally Important RNAs (2014) (16)
- A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery (2021) (16)
- Immune regulation of viral infection and vice versa (2005) (16)
- UFMylation inhibits the proinflammatory capacity of interferon-γ–activated macrophages (2020) (15)
- TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. (2020) (15)
- Erratum: Murine γ-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: A new model for virus-induced vascular disease (1998) (13)
- Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice (1995) (13)
- IMMUNE COMPLEXES SUPPRESS CELLULAR IMMUNITY a (1984) (13)
- Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis (2016) (13)
- Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells (2016) (12)
- Newly Discovered Viral E3 Ligase pK3 Induces Endoplasmic Reticulum-associated Degradation of Class I Major Histocompatibility Proteins and Their Membrane-bound Chaperones* (2012) (12)
- Effective Vaccination against Long-Term Gammaherpesvirus Latency (2003) (12)
- Identification of Alternative Transcripts Encoding the Essential Murine Gammaherpesvirus Lytic Transactivator RTA (2014) (11)
- Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity (2015) (11)
- A unique role for autophagy and Atg 16 L 1 in Paneth cells in murine and human intestine (2009) (10)
- SCID mice as models for parasitic infections. (1993) (9)
- High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth. (2018) (9)
- A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. (2021) (8)
- A 'fly-by' killing with a primordial cellular weapon (2008) (7)
- Drowning in Viruses (2019) (6)
- LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens (2018) (6)
- Specific Mutation of a Gammaherpesvirus-Expressed Antigen in Response to CD8 T Cell Selection In Vivo (2011) (6)
- Rapid Communication CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNg (2005) (6)
- Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection (2020) (6)
- Identification of anti-norovirus genes in mouse and human cells using genome-wide CRISPR activation screening (2018) (4)
- Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes (2022) (4)
- Corrigendum: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis (2013) (4)
- Transfer transcriptomic signatures for infectious diseases (2020) (3)
- Antibody therapy reverses biological signatures of COVID-19 progression (2021) (3)
- Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies (2022) (3)
- Host and viral genes that control herpesvirus vasculitis. (2002) (2)
- Correction: Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity (2017) (2)
- Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape (2022) (2)
- Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment (2020) (2)
- The Regulatory Role of Macrophages in Infection with Intracellular Pathogens (1986) (2)
- Wdfy4-deficiency reveals a critical role for cross-presentation in anti-viral and anti-tumor responses (2019) (2)
- A perspective on potential antibody-dependent enhancement of SARS-CoV-2 (2020) (1)
- Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide (2016) (1)
- Erratum: Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E6166–E6175) DOI: 10.1073/pnas.1706359114) (2018) (1)
- Author Correction: Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes (2021) (1)
- Autophagy gene-dependent intracellular immunity triggered by interferon-γ (2021) (1)
- Beth Cindy Levine (1960–2020) (2020) (1)
- Beth Levine (1960–2020) (2020) (0)
- Retraction Note: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells (2022) (0)
- MHCII+ Macrophages in Peritoneal and Pleural Cavities Require IRF4 for Development from Circulating Monocytes (2018) (0)
- Host tRNA Transcripts and Molecules Generated from Herpesvirus Identification of Novel MicroRNA-Like (2014) (0)
- #36: Can Astrovirus VA1, a Novel Human Astrovirus, Cause Diseases of the Central Nervous and Cardiovascular Systems? (2021) (0)
- Myxomavirus-derived serpin prolongs survival and reduces vasculitis in lethal herpesviral infection in mice by modulating thrombotic factor X and inflammatory cytokine IL-10 (2013) (0)
- Newly Discovered Viral E3 Ligase pK3 Induces ER-Associated Degradation of MHCI Proteins and Their Membrane-bound Chaperones (2012) (0)
- Interferon (cid:103) Regulates Acute and Latent Murine Cytomegalovirus Infection and Chronic Disease of the Great Vessels (1998) (0)
- Antibiotics Cause Multilineage Alteration of Hematopoiesis in Mice (2015) (0)
- NMR structure of gamma herpesvirus 68 a viral Bcl-2 homolog (2006) (0)
- Norovirus Discovery and Molecular Pathogenesis (2005) (0)
- Signals during Differentiation Coordinate Proliferation and Survival Invariant NKT Cells Require Autophagy To (2015) (0)
- Characterization of the novel molecule LysMD 3 1 LysMD 3 is a type II membrane protein without an in vivo role in the response to a range of pathogens (2018) (0)
- Conjugating Enzyme for Protein ISGylation Interferon-Inducible Ubiquitin E2, Ubc8, Is a (2014) (0)
- Microbiome Profiling by Whole Genome Sequencing During Acute and Chronic Lung Transplant Rejection (2014) (0)
- Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection (2020) (0)
- Expanded Enteric Virome and Altered Bacterial Microbiome in AIDS (2015) (0)
- Autophagy protects against high-dose Mycobacterium tuberculosis infection (2022) (0)
- Analysis of the Airways Virome after Lung Transplantation and Its Association with Clinical Outcomes (2016) (0)
- Author Correction: Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes (2021) (0)
- Identification of Novel MicroRNA-Like Molecules Generated from Herpesvirus and Host tRNA Transcripts (cid:1) (2010) (0)
- Animal models of infection-mediated vasculitis: implications for human disease (2000) (0)
- Latent Murine Herpesvirus-4 Infection Arms NK Cells. (2009) (0)
- CS08-3. ISG54 protects mice against VSV pathogenesis (2011) (0)
- Endomembrane structures utilized by pathogens are targeted for disruption by the ubiquitin-like conjugation systems of autophagy (INM8P.439) (2014) (0)
- American Association of Immunologists (AAI) Symposium: Microbial Pathogenesis (2005) (0)
- Mechanism of interferon-gamma (IFNγ) action during acute and latent murine cytomegalovirus (MCMV) infection (1999) (0)
- Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection (2018) (0)
- Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment (open state) (2020) (0)
- High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth (2018) (0)
- Autophagy protects against infection and inflammation in a murine model of tuberculosis (158.9) (2011) (0)
- Pathogenesis and IFNγ Regulation of γ-Herpesvirus Vasculitis (2001) (0)
- Chronic MNV is associated with suboptimal CD8 T cells (2013) (0)
- Beth Levine in memoriam (2020) (0)
- Abstract 329: Myxomavirus-derived Serpin Prolongs Survival and Reduces Vasculitis in MHV68 Infected Mice by Enhancing IL-10 (2013) (0)
- Mummichog, pathway and network analysis for Metabolomics (2015) (0)
- Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2 (2022) (0)
- Reply to “Viruses and vascular disease“ (1998) (0)
- Identification and Sequencing of a Novel Rodent Gammaherpesvirus That Establishes Acute and Latent Infection in Laboratory Mice (cid:1) (2011) (0)
- Gene expression differences between Crohn's disease aphthous ulcers and healthy Peyer's patches highlight novel therapeutic targets (2017) (0)
- Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape (2022) (0)
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