Hidde Ploegh | Academic Influence

Hidde Ploegh's AcademicInfluence.com Rankings

Hidde Ploegh

Biology

#1200

World Rank

#2041

Historical Rank

#617

USA Rank

Immunology

#71

World Rank

#77

Historical Rank

#24

USA Rank

Biochemistry

#200

World Rank

#253

Historical Rank

#102

USA Rank

biology Degrees

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Biology

Hidde Ploegh's Degrees

PhD Biochemistry University of Amsterdam

Why Is Hidde Ploegh Influential?

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According to Wikipedia, Hidde Lolke Ploegh is an immunologist at Boston Children's Hospital, known for his contributions in understanding antigen processing and the evasion of the immune system by viruses. Career and education Ploegh, a native of the Netherlands, received a Bachelor of Science degree in 1975, and a Master of Science degree in biology and chemistry in 1977, from the University of Groningen. Having worked for six months in Jack Strominger's lab at that time, he was able to continue his PhD studies under Strominger and received a doctorate from the University of Leiden. Ploegh would then go on to hold positions at a number of institutions such as the University of Cologne, the Netherlands Cancer Institute, Utrecht University , and Harvard Medical School, before becoming a member of the Whitehead Institute.

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Hidde Ploegh's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014) (1951)
CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance (2005) (1591)
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction (1996) (1167)
The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol (1996) (1126)
Empty MHC class I molecules come out in the cold (1990) (946)
Herpes simplex virus turns off the TAP to evade host immunity (1995) (922)
Viral subversion of the immune system. (2000) (890)
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining (2015) (880)
Viral strategies of immune evasion. (1998) (814)
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells (1992) (750)
A membrane protein required for dislocation of misfolded proteins from the ER (2004) (722)
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. (1998) (704)
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments (1991) (702)
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes (2008) (670)
Multiple associated proteins regulate proteasome structure and function. (2002) (646)
The known unknowns of antigen processing and presentation (2008) (643)
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration (2012) (626)
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. (2004) (604)
Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. (1986) (594)
Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum (2011) (587)
Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. (1996) (561)
The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc (2010) (560)
Cathepsin S required for normal MHC class II peptide loading and germinal center development. (1999) (532)
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase (1987) (521)
Regulation of monoubiquitinated PCNA by DUB autocleavage (2006) (520)
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. (2002) (501)
The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. (1997) (499)
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 (2008) (491)
A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 (2001) (472)
Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens (2009) (465)
Generation, translocation, and presentation of MHC class I-restricted peptides. (1995) (463)
Secreted cathepsin L generates endostatin from collagen XVIII (2000) (458)
The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route (1990) (455)
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2014) (455)
Sortagging: a versatile method for protein labeling. (2007) (448)
Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. (1996) (441)
Isolation and characterization of the intracellular MHC class II compartment (1994) (439)
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling (2007) (439)
Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules (1981) (437)
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. (1997) (426)
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport (2002) (423)
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. (2006) (420)
Mice lacking the MHC class II-associated invariant chain (1993) (409)
A microengraving method for rapid selection of single cells producing antigen-specific antibodies (2006) (404)
Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro (1990) (399)
Accessory molecules for Toll-like receptors and their function (2012) (390)
Predominant Autoantibody Production by Early Human B Cell Precursors (2003) (387)
Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway (1996) (385)
Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas (1994) (364)
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective (1993) (361)
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. (2011) (353)
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. (2005) (327)
The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. (1987) (323)
Cathepsin S activity regulates antigen presentation and immunity. (1998) (307)
Neuronal loss and brain atrophy in mice lacking cathepsins B and L (2002) (304)
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. (1995) (300)
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus (1993) (292)
Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. (1996) (288)
A proteolytic system that compensates for loss of proteasome function (1998) (286)
A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. (1993) (286)
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum (2007) (283)
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose (2016) (279)
HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. (1990) (277)
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. (1998) (268)
The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy (2018) (256)
Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions (2013) (254)
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. (2004) (254)
Peptide selection by MHC class I molecules (1991) (252)
A Single Protease, Apg4B, Is Specific for the Autophagy-related Ubiquitin-like Proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L* (2003) (252)
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib (2005) (250)
The WD‐40 repeat (1992) (250)
Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides (1984) (247)
Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection (2009) (247)
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. (2005) (246)
Proteases involved in MHC dass II antigen presentation (1999) (244)
Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor (2014) (237)
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins (2008) (237)
Durable antitumor responses to CD47 blockade require adaptive immune stimulation (2016) (237)
Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas. (2017) (234)
Role for Cathepsin F in Invariant Chain Processing and Major Histocompatibility Complex Class II Peptide Loading by Macrophages (2000) (232)
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. (2004) (232)
Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells (1999) (231)
Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β2‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association (1988) (230)
Making and breaking peptide bonds: protein engineering using sortase. (2011) (229)
Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation (2002) (226)
Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. (1992) (226)
Mechanisms, biology and inhibitors of deubiquitinating enzymes. (2007) (226)
Intracellular transport of MHC class II molecules. (1992) (224)
Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. (1993) (221)
Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. (2013) (220)
A role for N‐glycanase in the cytosolic turnover of glycoproteins (2003) (218)
Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator (1994) (215)
A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface (1997) (213)
Global gene disruption in human cells to assign genes to phenotypes (2011) (207)
Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism (1997) (205)
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER (2006) (201)
Site-specific N-terminal labeling of proteins using sortase-mediated reactions (2013) (201)
Peptide translocation by variants of the transporter associated with antigen processing. (1993) (199)
Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins (2004) (199)
Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity (2009) (198)
Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway. (2000) (198)
Cytokines Regulate Proteolysis in Major Histocompatibility Complex Class II–Dependent Antigen Presentation by Dendritic Cells (2001) (198)
Ubiquitin-like proteins. (2012) (198)
Proteolysis in MHC class II antigen presentation: who's in charge? (2000) (194)
Simultaneous protection of tissue physicochemical properties using polyfunctional crosslinkers (2018) (193)
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. (2009) (188)
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. (2014) (188)
Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate* (2005) (186)
In vivo discovery of immunotherapy targets in the tumour microenvironment (2014) (184)
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host (2011) (184)
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. (2007) (184)
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. (2004) (184)
Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens. (1979) (183)
The SUMO-Specific Protease SENP5 Is Required for Cell Division (2006) (181)
Noninvasive imaging of immune responses (2015) (179)
How MHC class II molecules reach the endocytic pathway. (1995) (179)
Inhibitors of oligosaccharide processing. (1985) (179)
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells (2009) (179)
Inhibition of non-homologous end joining increases the efficiency of CRISPR/Cas9-mediated precise [TM: inserted] genome editing (2015) (177)
Uvomorulin: a nonintegral membrane protein of early mouse embryo. (1983) (175)
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes. (1998) (174)
A subset of HLA-B27 molecules contains peptides much longer than nonamers. (1994) (174)
The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites* (2003) (173)
Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. (1996) (173)
Granulin is a soluble cofactor for toll-like receptor 9 signaling. (2011) (170)
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. (2001) (169)
Sortase-catalyzed transformations that improve the properties of cytokines (2011) (167)
Antigen Presentation and the Ubiquitin‐Proteasome System in Host–Pathogen Interactions (2006) (166)
An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes. (1986) (166)
Class II MHC peptide loading by the professionals. (2004) (164)
The α Chain of the T Cell Antigen Receptor Is Degraded in the Cytosol (1997) (163)
Identification of Proteins Associated with Murine Cytomegalovirus Virions (2004) (163)
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells (2017) (162)
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. (2003) (162)
Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice (2019) (159)
A Deubiquitinating Activity Is Conserved in the Large Tegument Protein of the Herpesviridae (2005) (159)
The Pathway of Us11-Dependent Degradation of Mhc Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate (1999) (157)
Quality and quantity control at the endoplasmic reticulum. (2010) (157)
Trophoblast Class I Major Histocompatibility Complex (MHC) Products Are Resistant to Rapid Degradation Imposed by the Human Cytomegalovirus (HCMV) Gene Products US2 and US11 (1998) (156)
Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2 (2001) (156)
Zwitterionic Polysaccharides Stimulate T Cells by MHC Class II-Dependent Interactions1 (2002) (155)
Protein glycosylation. (1990) (153)
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell‐cycle progression and stress tolerance (2007) (153)
Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes (2014) (151)
Chlamydia trachomatis‐derived deubiquitinating enzymes in mammalian cells during infection (2006) (149)
Crystal structure of a substrate-engaged SecY protein-translocation channel (2016) (146)
Control of cross‐presentation during dendritic cell maturation (2004) (145)
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. (2005) (145)
Protein quality control in the ER: balancing the ubiquitin checkbook. (2011) (143)
The HCMV Gene Products US11 and US2 Differ in Their Ability to Attack Allelic Forms of Murine Major Histocompatibility Complex (MHC) Class I Heavy Chains (1997) (142)
Exploiting Nanobodies' Singular Traits. (2018) (141)
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. (2013) (141)
A closer look at proteolysis and MHC-class-II-restricted antigen presentation. (2002) (139)
Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents. (1998) (139)
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond (2005) (138)
Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing (2015) (138)
Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes (1995) (137)
Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages (2011) (136)
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum (2006) (136)
Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. (2001) (136)
Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells. (1998) (134)
A glycosylated type I membrane protein becomes cytosolic when peptide: N‐glycanase is compromised (2004) (134)
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice (2005) (132)
Dislocation of Type I Membrane Proteins from the ER to the Cytosol Is Sensitive to Changes in Redox Potential (1998) (131)
Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment (1995) (131)
Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It (2011) (129)
Mapping functional regions in the lumenal domain of the class II- associated invariant chain (1994) (129)
Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes (2007) (129)
Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. (1998) (126)
Rapid Turnover of Unspliced Xbp-1 as a Factor That Modulates the Unfolded Protein Response* (2006) (125)
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. (2000) (125)
Varicella-Zoster Virus Retains Major Histocompatibility Complex Class I Proteins in the Golgi Compartment of Infected Cells (2001) (125)
Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. (2006) (125)
Lipid modification of proteins through sortase-catalyzed transpeptidation. (2008) (125)
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. (2008) (121)
Site‐Specific Protein Labeling via Sortase‐Mediated Transpeptidation (2009) (121)
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. (2004) (119)
Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism (2016) (119)
Release of Signal Peptide Fragments into the Cytosol Requires Cleavage in the Transmembrane Region by a Protease Activity That Is Specifically Blocked by a Novel Cysteine Protease Inhibitor* (2000) (118)
Increased resistance to non-MHC-restricted cytotoxicity related to HLA A, B expression. Direct demonstration using beta 2-microglobulin-transfected Daudi cells. (1988) (117)
A Straight Path to Circular Proteins* (2009) (117)
A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens (2013) (117)
The Active Site of ICP47, a Herpes Simplex Virus–encoded Inhibitor of the Major Histocompatibility Complex (MHC)-encoded Peptide Transporter Associated with Antigen Processing (TAP), Maps to the NH2-terminal 35 Residues (1997) (116)
Suppression of class I human histocompatibility leukocyte antigen by c- myc is locus specific (1989) (116)
Specific role for cathepsin S in the generation of antigenic peptides in vivo (2002) (115)
An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model (2017) (113)
A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly (2016) (113)
High-Molecular-Weight Protein (pUL48) of Human Cytomegalovirus Is a Competent Deubiquitinating Protease: Mutant Viruses Altered in Its Active-Site Cysteine or Histidine Are Viable (2006) (113)
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway (2008) (113)
Murine Polyomavirus Requires the Endoplasmic Reticulum Protein Derlin-2 To Initiate Infection (2006) (112)
Human Cytomegalovirus US2 Endoplasmic Reticulum-Lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-Specific Manner (2001) (112)
Murine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop1 (2009) (112)
Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. (2006) (111)
Altered natural killer cell repertoire in Tap-1 mutant mice. (1994) (111)
Intracellular targeting of the proteasome. (2000) (111)
Preparation of unnatural N-to-N and C-to-C protein fusions (2012) (109)
Protein quality control in the endoplasmic reticulum (2014) (108)
Molecular cloning of a human histocompatibility antigen cDNA fragment. (1980) (108)
Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity (2007) (107)
Recent advances in sortase-catalyzed ligation methodology. (2016) (107)
The Human Cytomegalovirus US10 Gene Product Delays Trafficking of Major Histocompatibility Complex Class I Molecules (2002) (106)
Cellular internalization of cytolethal distending toxin: a new end to a known pathway (2005) (106)
Gene expression analysis of B‐lymphoma cells resistant and sensitive to bortezomib * (2006) (104)
Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. (2004) (103)
Biosynthesis and cell surface localization of nonglycosylated human histocompatibility antigens. (1981) (103)
Asparagine Endopeptidase Is Not Essential for Class II MHC Antigen Presentation but Is Required for Processing of Cathepsin L in Mice1 (2005) (103)
Substrate specificity of allelic variants of the TAP peptide transporter. (1994) (103)
Peptide loading of empty major histocompatibility complex molecules on RMA‐S cells allows the induction of primary cytotoxic T lymphocyte responses (1991) (102)
In Vitro Translation and Assembly of a Complete T Cell Receptor–CD3 Complex (1997) (102)
Protein Unfolding Is Not a Prerequisite for Endoplasmic Reticulum-to-Cytosol Dislocation* (2003) (102)
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease (2017) (100)
Purification, cDNA‐cloning and expression of human diacylglycerol kinase (1990) (100)
Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control (2011) (100)
Anti–CTLA-4 therapy requires an Fc domain for efficacy (2018) (99)
Kaposi's Sarcoma-Associated Herpesvirus K3 Utilizes the Ubiquitin-Proteasome System in Routing Class I Major Histocompatibility Complexes to Late Endocytic Compartments (2002) (99)
Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells (2010) (99)
Visualization of the ER‐to‐cytosol dislocation reaction of a type I membrane protein (2002) (97)
Cytomegaloviruses use multiple mechanisms to elude the host immune response. (1997) (96)
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier (2011) (96)
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. (2005) (95)
A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis (2009) (95)
Tubulation of Class II MHC Compartments Is Microtubule Dependent and Involves Multiple Endolysosomal Membrane Proteins in Primary Dendritic Cells1 (2007) (95)
Inhibition of Major Histocompatibility Complex Class I Antigen Presentation in Pig and Primate Cells by Herpes Simplex Virus Type 1 and 2 ICP47 (1998) (95)
Human Cytomegalovirus Open Reading Frame TRL11/IRL11 Encodes an Immunoglobulin G Fc-Binding Protein (2001) (94)
Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. (1979) (93)
Enzymatic Blockade of the Ubiquitin-Proteasome Pathway (2011) (93)
Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. (1994) (93)
The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products. (1999) (92)
Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells (2014) (90)
Peptide-induced stabilization and intracellular localization of empty HLA class I complexes (1992) (90)
Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. (2001) (89)
Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen. (1995) (89)
Viruses use stealth technology to escape from the host immune system. (1997) (88)
Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix (2019) (88)
Discovery of antivirals against smallpox. (2004) (87)
Screen for ISG15-crossreactive Deubiquitinases (2007) (87)
A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation (2007) (87)
HLA-restricted recognition of viral antigens in HLA transgenic mice (1987) (87)
Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. (2009) (86)
Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA‐B27) and light (beta 2‐microglobulin) chains of HLA class I antigens. (1987) (86)
M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins. (2012) (86)
Invariant Chain Controls the Activity of Extracellular Cathepsin L (2002) (85)
Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection (2015) (85)
Localized CD47 blockade enhances immunotherapy for murine melanoma (2017) (84)
How lamina-associated polypeptide 1 (LAP1) activates Torsin (2014) (84)
Sortase A as a tool for high‐yield histatin cyclization (2011) (84)
The p41 isoform of invariant chain is a chaperone for cathepsin L (2001) (83)
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. (1993) (83)
Gene conversion‐like mechanisms may generate polymorphism in human class I genes. (1986) (82)
Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen‐presenting cells (1989) (82)
Inhibition of N‐linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins. (1984) (81)
Effects of the glucosidase inhibitors nojirimycin and deoxynojirimycin on the biosynthesis of membrane and secretory glycoproteins. (1983) (80)
Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains (1995) (80)
Human Cytomegalovirus Protein US11 Provokes an Unfolded Protein Response That May Facilitate the Degradation of Class I Major Histocompatibility Complex Products (2005) (79)
Proteolysis and antigen presentation by MHC class II molecules (2002) (79)
The cell biology of antigen presentation. (2002) (79)
T Cells Induce Extended Class II MHC Compartments in Dendritic Cells in a Toll-Like Receptor-Dependent Manner 1 (2003) (78)
Human Cytomegalovirus Gene Products US2 and US11 Differ in Their Ability To Attack Major Histocompatibility Class I Heavy Chains in Dendritic Cells (2002) (78)
Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade (2019) (77)
PD-L1 is an activation-independent marker of brown adipocytes (2017) (76)
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum (2006) (76)
Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution (2007) (76)
The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation (2010) (76)
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers (2008) (75)
Preferred in vivo ubiquitination sites (2004) (74)
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells (2005) (74)
Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases (2013) (74)
Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells. (1996) (74)
Small‐Molecule Inhibitors and Probes for Ubiquitin‐ and Ubiquitin‐Like‐Specific Proteases (2005) (73)
Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture (2016) (73)
Protein Ligation in Living Cells Using Sortase (2012) (73)
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity (2008) (73)
Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery. (2009) (72)
Viral Interference with B7-1 Costimulation: A New Role for Murine Cytomegalovirus Fc Receptor-11 (2006) (72)
Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex (1982) (72)
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. (2008) (71)
Membrane-specific, Host-derived Factors Are Required for US2- and US11-mediated Degradation of Major Histocompatibility Complex Class I Molecules* (2002) (71)
Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes (2013) (70)
Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. (2006) (70)
Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages (2013) (69)
The phenotype of H‐2M‐deficient mice is dependent on the MHC class II molecules expressed (1998) (69)
Use of 18F-2-Fluorodeoxyglucose to Label Antibody Fragments for Immuno-Positron Emission Tomography of Pancreatic Cancer (2015) (69)
Are MHC-bound peptides a nuisance for positive selection? (1994) (68)
Viral immune evasion strategies and the underlying cell biology. (2001) (68)
Sortase A: A Model for Transpeptidation and Its Biological Applications. (2018) (68)
ElaD, a Deubiquitinating Protease Expressed by E. coli (2007) (68)
The alpha chain of the T cell antigen receptor is degraded in the cytosol. (1997) (67)
Different types of allospecific CTL clones identified by their ability to recognize peptide loading‐defective target cells (1991) (67)
Differential priming of CD8 and CD4 T‐cells in animal models of autoimmune hepatitis and cholangitis (2007) (66)
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition (2020) (66)
Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization (2004) (66)
Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. (2004) (65)
Association with beta 2-microglobulin controls the expression of transfected human class I genes. (1987) (65)
Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification (2006) (65)
Profiling antibody responses by multiparametric analysis of primary B cells (2008) (65)
The e S-S ence of -SH in the ER (1998) (64)
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor (2001) (64)
Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules (2002) (63)
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon. (1993) (63)
The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-rich Repeat-containing Protein 8D (2014) (63)
Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity (2014) (63)
Identification of host cell factors required for intoxication through use of modified cholera toxin (2011) (62)
Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure (2018) (62)
Sialylneolacto-N-tetraose c (LSTc)-bearing Liposomal Decoys Capture Influenza A Virus* (2013) (62)
Ubiquitin--conserved protein or selfish gene? (2005) (62)
A Human Herpesvirus 7 Glycoprotein, U21, Diverts Major Histocompatibility Complex Class I Molecules to Lysosomes (2001) (61)
Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover. (2006) (61)
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. (1995) (61)
Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83 (2016) (60)
Antigen-specific B cell receptor sensitizes B cells to infection by influenza virus (2013) (60)
Toxoplasma gondii Superinfection and Virulence during Secondary Infection Correlate with the Exact ROP5/ROP18 Allelic Combination (2015) (60)
The CD8 T-Cell Response against Murine Gammaherpesvirus 68 Is Directed toward a Broad Repertoire of Epitopes from both Early and Late Antigens (2008) (60)
Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma gondii Obtained via SCNT (2010) (60)
A hydrophobic transmembrane segment at the carboxyl terminus of thy-1. (1985) (59)
Substrate Filtering by the Active Site Crossover Loop in UCHL3 Revealed by Sortagging and Gain-of-function Mutations* (2009) (59)
The B Cell Receptor Promotes B Cell Activation and Proliferation through a Non-ITAM Tyrosine in the Igα Cytoplasmic Domain (2006) (58)
Chemical modification of the glucosidase inhibitor 1-deoxynojirimycin. Structure-activity relationships. (1991) (58)
The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes. (1997) (57)
Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. (2016) (57)
Stochastic Cytokine Expression Induces Mixed T Helper Cell States (2013) (56)
Mechanisms of induction of primary virus‐specific cytotoxic T lymphocyte responses (1992) (56)
GPR107, a G-protein-coupled Receptor Essential for Intoxication by Pseudomonas aeruginosa Exotoxin A, Localizes to the Golgi and Is Cleaved by Furin*♦ (2014) (56)
Individual cathepsins degrade immune complexes internalized by antigen‐presenting cells via Fcγ receptors (2001) (56)
Intermediates in the Assembly and Degradation of Class I Major Histocompatibility Complex (MHC) Molecules Probed with Free Heavy Chain–specific Monoclonal Antibodies (1996) (56)
Yeast N‐glycanase distinguishes between native and non‐native glycoproteins (2004) (55)
Empty Class II Major Histocompatibility Complex Created by Peptide Photolysis Establishes the Role of DM in Peptide Association* (2007) (55)
tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae (2015) (55)
Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3 (2009) (55)
A guide to antigen processing and presentation (2022) (55)
A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities* (2009) (55)
Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry (2013) (55)
aberrant expression of HLA Class‐I antigens in burkitt lymphoma cells (1991) (55)
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells (2014) (54)
Attachment of Chlamydia trachomatis L2 to host cells requires sulfation (2012) (54)
Putting together an MHC class I molecule. (1993) (53)
Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles. (2018) (52)
Ras (proto)oncogene induces N‐linked carbohydrate modification: temporal relationship with induction of invasive potential. (1988) (52)
Virus subversion of immunity: a structural perspective. (2001) (51)
Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia (2016) (51)
One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. (2018) (51)
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections (2021) (51)
Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology (2000) (50)
Ubiquitinylation of the Cytosolic Domain of a Type I Membrane Protein Is Not Required to Initiate Its Dislocation from the Endoplasmic Reticulum* (2003) (50)
Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments (2002) (50)
Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides. (1994) (49)
Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs (2018) (49)
Lack of correlation between levels of MHC class I antigen and susceptibility to lysis of small cellular lung carcinoma (SCLC) by natural killer cells. (1989) (49)
Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins (2013) (49)
BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum (2011) (49)
The fate of the three subunits of major histocompatibility complex class I molecules (1992) (49)
Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H‐2DM (2000) (48)
Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice. (1988) (48)
Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes. (1997) (48)
Myeloid Differentiation Factor 88 Is Required for Cross-Priming In Vivo1 (2004) (48)
A Functional Ubiquitin-Specific Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 Is Active during the Course of Infection (2007) (48)
Intracellular Expression of Camelid Single-Domain Antibodies Specific for Influenza Virus Nucleoprotein Uncovers Distinct Features of Its Nuclear Localization (2014) (47)
Functional Proteomics of the Active Cysteine Protease Content in Drosophila S2 Cells* (2003) (46)
Cotranslational endoplasmic reticulum assembly of FcɛRI controls the formation of functional IgE-binding receptors (2005) (46)
Identification of new B27 subtypes (B27C and B27D) prevalent in oriental populations. (1986) (45)
End the wasteful tyranny of reviewer experiments (2011) (45)
Membrane specializations and endosome maturation in dendritic cells and B cells. (2004) (45)
Qa-2–Dependent Selection of Cd8α/α T Cell Receptor α/β+ Cells in Murine Intestinal Intraepithelial Lymphocytes (2000) (45)
Proteasome inhibitors and antigen presentation. (1997) (45)
Characterization of a G-protein beta-subunit gene from the nematode Caenorhabditis elegans. (1990) (45)
Biochemical analysis of variant HLA-B27 antigens. (1983) (45)
Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells (2002) (45)
Site-specific protein modification using immobilized sortase in batch and continuous-flow systems (2015) (45)
Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer. (2003) (45)
Preferred size of peptides that bind to H‐2 Kb is sequence dependent (1992) (44)
LMP2 expression and proteasome activity in NOD mice (2000) (44)
A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product (1992) (44)
Enhanced Cell Capture on Functionalized Graphene Oxide Nanosheets through Oxygen Clustering. (2017) (44)
Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease (2017) (44)
N-Linked Glycosylation Does Not Impair Proteasomal Degradation but Affects Class I Major Histocompatibility Complex Presentation* (2008) (44)
Intercellular trafficking of the nuclear oncoprotein DEK (2013) (44)
Class Ia MHC-Deficient BALB/c Mice Generate CD8+ T Cell-Mediated Protective Immunity Against Listeria monocytogenes Infection1 (2003) (44)
Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans (2015) (43)
XBP-1-Deficient Plasmablasts Show Normal Protein Folding but Altered Glycosylation and Lipid Synthesis1 (2009) (43)
Allosteric activation of apicomplexan calcium-dependent protein kinases (2015) (43)
Phenotypic lentivirus screens to identify functional single domain antibodies (2016) (43)
Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules (2001) (43)
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection (2020) (43)
Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter. (2016) (42)
Cocapture of cognate and bystander antigens can activate autoreactive B cells (2017) (42)
Differential reactivity of residual CD8+ T lymphocytes in TAP1 and β2‐microglobulin mutant mice (1995) (42)
One-Step Enzymatic Modification of the Cell Surface Redirects Cellular Cytotoxicity and Parasite Tropism (2014) (41)
Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics. (2016) (41)
IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells (2012) (41)
Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization (2018) (41)
Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs (2016) (41)
Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference (1993) (41)
Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes (2009) (40)
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones (2016) (40)
Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection. (2013) (40)
z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress (2006) (40)
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short‐term plasticity and vesicle number (2014) (40)
Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity (2013) (40)
Invariant chain can bind MHC class II at a site other than the peptide binding groove. (1998) (39)
Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments (2020) (39)
An Evaluation of the Significance of Amino Acid Sequence Homologies in Human Histocompatibility Antigens (HLA‐A and HLA‐B) with Immunoglobulins and Other Proteins, Using Relatively Short Sequences (1980) (39)
Assembly and Intracellular Targeting of the βγ Subunits of Heterotrimeric G Proteins (1997) (39)
Recycling glycoproteins do not return to the cis-Golgi (1988) (39)
The effect of anchor residue modifications on the stability of major histocompatibility complex class I‐peptide interactions (1993) (38)
B-cell receptor signaling in lymphoid malignancies and autoimmunity. (2014) (38)
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling (2016) (38)
Derlin-2-Deficient Mice Reveal an Essential Role for Protein Dislocation in Chondrocytes (2011) (37)
Orthogonal labeling of M13 minor capsid proteins with DNA to self-assemble end-to-end multiphage structures. (2013) (37)
Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice (2013) (37)
AID−/−μs−/− Mice Are Agammaglobulinemic and Fail to Maintain B220−CD138+ Plasma Cells1 (2007) (36)
Site-specific sequential protein labeling catalyzed by a single recombinant ligase. (2019) (36)
The Tetraspanin CD82 Is Specifically Recruited to Fungal and Bacterial Phagosomes prior to Acidification (2010) (36)
Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor (2016) (36)
Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12–like Heterodimers Extracellularly (2014) (36)
The Human Cytomegalovirus US8 Glycoprotein Binds to Major Histocompatibility Complex Class I Products (2002) (36)
MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation. (2002) (36)
Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation1 (2008) (36)
Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene (1995) (35)
Phosphoproteomic analysis with a solid-phase capture-release-tag approach. (2005) (35)
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. (2004) (35)
US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide* 210 (2002) (35)
Dendritic Cells: Biology and Clinical Applications (1999) (35)
Exploring cellular biochemistry with nanobodies (2020) (35)
HypE-specific Nanobodies as Tools to Modulate HypE-mediated Target AMPylation (2015) (34)
The Transmembrane Segment of a Tail-anchored Protein Determines Its Degradative Fate through Dislocation from the Endoplasmic Reticulum* (2010) (34)
Activation of protein kinase C accelerates internalization of transferrin receptor but not of major histocompatibility complex class I, independent of their phosphorylation status. (1992) (34)
Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. (1996) (34)
A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection (2009) (34)
HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. (1999) (34)
One‐Dimensional Isoelectric Focusing of Proteins in Slab Gels (1995) (34)
Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules (1992) (33)
Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: Evolutionary aspects (2004) (33)
The ER‐Lumenal Domain of the HHV‐7 Immunoevasin U21 Directs Class I MHC Molecules to Lysosomes (2003) (33)
The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). (2002) (33)
Assembly and intracellular transport of major histocompatibility complex molecules. (1991) (33)
Site-Specific Chemoenzymatic Labeling of Aerolysin Enables the Identification of New Aerolysin Receptors (2014) (33)
Elimination In Vivo of Developing T Cells by Natural Killer Cells (2003) (32)
Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans. (2017) (32)
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response (2016) (32)
Requirements for T Cell-Polarized Tubulation of Class II+ Compartments in Dendritic Cells 1 (2003) (32)
Competition by inhibitory oligonucleotides prevents binding of CpG to C‐terminal TLR9 (2011) (32)
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy (2018) (32)
Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines. (1989) (32)
Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2016) (32)
Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells1 (2009) (31)
Structural and Functional Analysis of Human Cytomegalovirus US3 Protein (2004) (31)
A Viral Deubiquitylating Enzyme Restores Dislocation of Substrates from the Endoplasmic Reticulum (ER) in Semi-intact Cells* (2012) (31)
The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. (2006) (31)
Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes (2012) (31)
Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: evolutionary aspects (2004) (31)
Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation. (2017) (31)
Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination (2012) (30)
Chemoenzymatic Site-Specific Labeling of Influenza Glycoproteins as a Tool to Observe Virus Budding in Real Time (2012) (30)
Differential dependence of CD 4 CD 25 regulatory and natural killer-like T cells on signals leading to NF-B activation (2004) (30)
Lessons from viral manipulation of protein disposal pathways. (2002) (30)
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). (2012) (30)
Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e. (2016) (30)
A novel immunoadsorption device for removing beta2-microglobulin from whole blood. (2001) (29)
Acidic Amino Acid Residues in the Juxtamembrane Region of the Nucleotide-Sensing TLRs Are Important for UNC93B1 Binding and Signaling (2013) (29)
Catch‐and‐Release Probes Applied to Semi‐Intact Cells Reveal Ubiquitin‐Specific Protease Expression in Chlamydia trachomatis Infection (2013) (29)
Pathways Accessory to Proteasomal Proteolysis Are Less Efficient in Major Histocompatibility Complex Class I Antigen Production* (2003) (29)
Soluble class I antigens: a conundrum with no solution? (1987) (28)
Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface? (2000) (28)
A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NF-κB (2013) (28)
Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets (2017) (28)
An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting (2004) (28)
N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response (1990) (28)
Definition of four HLA-A2 subtypes by CML typing and biochemical analysis (2004) (27)
Lack of expression of HLA-B27 gene in transgenic mouse trophoblast. Conserved genetic pressures underlying extra-embryonic development (1989) (27)
Sequence and structure evolved separately in a ribosomal ubiquitin variant (2007) (27)
Introduction of oxygen into the alkyl chain of N-decyl-dNM decreases lipophilicity and results in increased retention of glucose residues on N-linked oligosaccharides. (1994) (26)
The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice* (2014) (26)
Mice deficient in invariant‐chain and MHC class II exhibit a normal mature B2 cell compartment (2004) (25)
Improved GPCR ligands from nanobody tethering (2020) (25)
In vivo control of endosomal architecture by class II‐associated invariant chain and cathepsin S (2005) (25)
A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells (2015) (25)
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides (2017) (25)
Retrograde transport from the Golgi region to the endoplasmic reticulum is sensitive to GTP gamma S (1992) (25)
Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors (2000) (24)
The assembly of H2‐Kb class I molecules translated in vitro requires oxidized glutathione and peptide (1993) (24)
Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/Peptide Complex1 (2004) (24)
Inhibition of N‐linked oligosaccharide trimming mannosidases blocks human B cell development. (1986) (24)
A soluble, single‐chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell‐surface‐associated Kd (1993) (24)
In vivo detection of antigen-specific CD8 T cells by immuno-positron emission tomography (2020) (24)
The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment (2016) (23)
Immune escape by Epstein-Barr virus (EBV) carrying Burkitt's lymphoma: in vitro reconstitution of sensitivity to EBV-specific cytotoxic T cells. (1992) (23)
Translating cell biology in vitro to immunity in vivo (2004) (23)
DM exchange mechanism (1995) (23)
Deviant trafficking of I‐Ad mutant molecules is reflected in their peptide binding properties (1999) (23)
Biochemical and cellular identification of HLA-Bw44 subtypes. (1984) (23)
A pseudosubstrate peptide inhibits protein kinase C‐mediated phosphorylation in permeabilized Rat‐1 cells (1990) (23)
Synthesis of oxygen-substituted N-alkyl 1-deoxynojirimycin derivatives: Aza sugar α-glucosidase inhibitors showing antiviral (HIV-1) and immunosuppressive activity (1994) (22)
The two pathways SEL 1 L , the homologue of yeast Hrd 3 p , is involved in protein dislocation from the mammalian ER (2006) (22)
Biosynthesis of murine immunoglobulin D: Heterogeneity of glycosylation (1982) (22)
Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments. (2015) (22)
Antigen-specific induction of regulatory T cells in vivo and in vitro. (2011) (21)
Ubiquitin-Dependent Control of Class II MHC Localization Is Dispensable for Antigen Presentation and Antibody Production (2011) (21)
Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product (2014) (21)
Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis (2012) (20)
MHC class II dimer of dimers (1993) (20)
CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection. (2012) (19)
Chemical biology: Dressed-up proteins (2007) (19)
Distribution and Elimination of the Glycosidase Inhibitors 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin in the Rat in Vivo (1992) (19)
A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity (2019) (19)
Analysis of human class I antigens by two-dimensional gel electrophoresis (1983) (19)
Correction: Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining (2016) (19)
Nanobodies in cancer. (2020) (19)
Vesicular stomatitis virus N protein‐specific single‐domain antibody fragments inhibit replication (2017) (19)
TLRs bent into shape (2007) (18)
The ligand recognized by ELAM‐1 on HL60 cells is not carried by N‐linked oligosaccharides (1991) (18)
Chemical Warfare and Mycobacterial Defense (2003) (18)
Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells. (2015) (18)
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: synthesis of active site-directed probes. (2005) (17)
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity (2022) (17)
A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. (2013) (17)
Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens. (1980) (17)
Biochemical evidence that the DLA-B locus codes for a class II determinant expressed on all canine peripheral blood lymphocytes. (1989) (17)
Development of an influenza virus protein array using Sortagging technology. (2012) (17)
Major Histocompatibility Complex Class 1I Compartments in Human B Lymphoblastoid Cells Are Distinct from Early Endosomes By Peter J. Peters,* Gra~a Raposo,* Jacques J. Neefjes,~ (1995) (17)
A biochemical characterization of feline MHC products: Unusually high expression of class 11 antigens on peripheral blood lymphocytes (2004) (17)
Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation. (2019) (17)
rAMPing Up Stress Signaling: Protein AMPylation in Metazoans. (2017) (16)
HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses. (2021) (16)
Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity (2018) (16)
An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion (2022) (16)
Faculty Opinions recommendation of E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. (2014) (16)
Nanobodies as non-invasive imaging tools (2020) (16)
Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin. (2004) (15)
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes (2022) (15)
Antigen presentation: A protease draws first blood (1998) (15)
Association of Mouse Mammary Tumor Virus Superantigen with MHC Class II During Biosynthesis1 (2001) (15)
Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00446j Click here for additional data file. (2017) (15)
Non-carrier-mediated uptake of the mannosidase I inhibitor 1-deoxymannojirimycin by K562 erythroleukemic cells. (1989) (14)
Immune‐privileged embryonic Swiss mouse STO and STO cell‐derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines (2006) (14)
Destruction of proteins as a creative force. (1997) (14)
Synthesis of the Antibiotic 1,5-dideoxy-1,5-imino-d-mannitol (1988) (14)
Intracellular interactions of transferrin and its receptor during biosynthesis (1990) (13)
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants (2021) (13)
The Chaperone BAG6 Captures Dislocated Glycoproteins in the Cytosol (2014) (13)
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. (2005) (13)
Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination (2020) (13)
Bridging B Cell and T Cell Recognition of Antigen (2007) (13)
Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein. (2019) (13)
A new MHC locus that influences class I peptide presentation. (1997) (13)
The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent (2017) (13)
Targeted Delivery of Cyclotides via Conjugation to a Nanobody. (2018) (12)
CD82 controls CpG‐dependent TLR9 signaling (2019) (12)
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes (2021) (12)
Nanobody–Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses (2018) (12)
A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure (2020) (12)
Chemical modification of azasugars, inhibitors of N‐glycoprotein‐processing glycosidases and of HIV‐I infection: Review and structure‐activity relationships (2010) (11)
Molecular characterization of HLA-A, B homologues in owl monkeys and other nonhuman primates (2005) (11)
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection (2022) (11)
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies (2021) (11)
Internalization of Influenza Virus and Cell Surface Proteins Monitored by Site-Specific Conjugation of Protease-Sensitive Probes. (2019) (11)
Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells. (2001) (11)
Qa-2–Dependent Selection of Cd8α/α T Cell Receptor α/β 1 Cells in Murine Intestinal Intraepithelial Lymphocytes (2001) (11)
Intestinal Colonization by Candida albicans Alters Inflammatory Responses in Bruton's Tyrosine Kinase-Deficient Mice (2014) (11)
Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. (2010) (10)
Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen (2018) (10)
Synthesis of tritium labeled KRN7000 (2006) (10)
Amino Acid Copolymers That Alleviate Experimental Autoimmune Encephalomyelitis In Vivo Interact with Heparan Sulfates and Glycoprotein 96 in APCs (2013) (9)
Immunochemical ANALYSIS OF GLYCOSYLATED AND nonglycosylated dla class I antigens (2004) (9)
Effect of reduced temperature on glycoprotein (Ig, HLA) processing and transport in lymphoid cells. (1985) (9)
A nomenclature solution to mouse MHC confusion. (1999) (9)
Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies (2021) (9)
Logic of the Immune System (2013) (9)
Antigen presentation: Untapped peptides (1993) (9)
Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute‐phase Toxoplasma gondii burden (2016) (9)
Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells. (2021) (8)
Trafficking and assembly of MHC molecules: how viruses elude the immune system. (1995) (8)
Repertoire‐Determining Role of Peptide in the Positive Selection of CD8+ T cells (1993) (8)
Nanobodies as in vivo, non-invasive, imaging agents (2021) (8)
ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function (2021) (8)
Herpesvirus evasion of T-cell immunity (2007) (8)
Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4+ T Cells (2021) (8)
Podocytes exhibit a specialized protein quality control employing derlin-2 in kidney disease. (2018) (8)
Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. (1995) (8)
Nothing 'gainst Time's Scythe Can Make Defense... (2004) (8)
Post‐Translational Modification: Phosphorylation and Phosphatases (2003) (7)
Determination of attachment sites for N-linked carbohydrate groups of class II histocompatibility α-chain and analysis of possible o-linked glycosylation of α- and γ-chains (1986) (7)
The βγ subunits of heterotrimeric G proteins acquire detergent insolubility directly at the plasma membrane (1997) (7)
Characterization of in vivo expanded OspA-specific human T-cell clones. (2005) (7)
Isolation and characterization of three cDNAs coding for Rab proteins from the albumen gland of the mollusc Lymnaea stagnalis. (1993) (7)
Manipulation of Glycans on Antigens of the Major Histocompatibility Complex (1985) (7)
Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity (2020) (6)
Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo (2021) (6)
Screen for ISG 15-crossreactive Deubiquitinases (2007) (6)
Activation of human B cells: involvement of surface immunoglobulin as evidenced by two biochemically distinct types of response to Staphylococcus aureus. (1986) (6)
Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions (2016) (6)
Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids (2019) (6)
Microbiology. Chemical warfare and mycobacterial defense. (2003) (6)
Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell. (2017) (5)
Editorial: Crystal death: it's not always the inflammasome… (2017) (5)
The Angelman Syndrome-associated ubiquitin ligase Ube 3 A regulates synapse development by ubiquitinating Arc (2010) (5)
Structural and functional studies on the G(o) protein. (1993) (5)
Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens. (1999) (5)
Influenza virus changes cell-surface glycoproteins including major histocompatibility complex determinants on lymphocytes. (1989) (5)
High-resolution one-dimensional isoelectric focusing of mouse MHC class I antigens (1990) (5)
Correction: Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth (2008) (5)
A monoclonal antibody that causes the heterotrimeric G‐protein Go to release its βγ subunits (1996) (4)
Catching proteases in action with microarrays. (2004) (4)
Antigen-specific induction of CD4+CD8αα+ intraepithelial T lymphocytes by Bacteroidetes species (2020) (4)
Adaptive immunity mediated by Natural Killer cells. (2012) (4)
A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NFB Citation (2013) (4)
Correction for Chahal et al., Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose (2016) (4)
Hydrogel-Based Stamping Technology for Solution-Free Blood Cell Staining. (2021) (4)
New Members of the National Academy of Sciences (1997) (4)
Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells. (1992) (4)
A feline class II α gene with striking similarity to the HLA-DPA pseudogene (2004) (4)
Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH (2020) (4)
Homeostatic Regulation The Unfolded Protein Response : From Stress Pathway to (2011) (4)
Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo (2013) (4)
Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism (2022) (4)
Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands (2021) (3)
Use of [ superscript 18 ] F 2-Fluorodeoxyglucose to Label Antibody Fragments for Immuno-Positron Emission Tomography of Pancreatic Cancer (2015) (3)
Transnuclear TRP 1-specific CD 8 T cells with high or low affinity TCRs show equivalent anti-tumor activity (2014) (3)
Structural heterogeneity of a human melanoma-associated antigen. (1989) (3)
Biosynthesis and assembly of MHC antigens. (1990) (3)
Massively Parallel Microfluidic Cell-Pairing Platform for the Statistical Study of Immunological Cell-Cell Interactions (2011) (3)
Subunit interactions of the Go protein (1992) (3)
MHC products: biosynthesis, intracellular traffic, and "empty" molecules. (1992) (3)
Chapter 4 Complete Primary Structure of Human Histocompatibility Antigen Hla-B7: Evolutionary and Functional Implications (1980) (3)
Obituary: Don Craig Wiley (1944–2001) (2002) (3)
Assembly and Intracellular Transport of MHC Molecules (1993) (2)
The betagamma subunits of heterotrimeric G proteins acquire detergent insolubility directly at the plasma membrane. (1997) (2)
LRRC 8 D Mediates Transport of Blasticidin S 1 The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-Rich Repeat-Containing Protein 8 D (2014) (2)
Determination of attachment sites for N-linked carbohydrate groups of class II histocompatibility alpha-chain and analysis of possible O-linked glycosylation of alpha- and gamma-chains. (1986) (2)
Secretion of circular proteins using sortase. (2014) (2)
In vitro AMPylation Assays Using Purified, Recombinant Proteins. (2017) (2)
CD8α[superscript +] Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites (2011) (2)
Monoclonal antibodies that distinguish between free and complexed heterotrimeric G protein β subunits (1997) (2)
Antigen recognition. (1998) (2)
An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model (2017) (2)
Immune and other responses to viral infections. (2009) (2)
Synthesis of the antibiotic 1,5-dideoxy-1,5-imino-D-glucitol; concomitant formation of the D-mannitol analogue (2010) (2)
Biosynthesis and assembly of MHC antigens. (1990) (2)
A molecule's right to choose: how diabetogenic class II MHC products bind peptides. (2005) (2)
Cover Picture: Catch-and-Release Probes Applied to Semi-Intact Cells Reveal Ubiquitin-Specific Protease Expression in Chlamydia trachomatis Infection (ChemBioChem 3/2013) (2013) (2)
Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes (2008) (2)
An HLA lost mutation may lead to leukemic relapse of recipient type six years after bone marrow transplantation. (1987) (2)
The otubain YOD 1 is a deubiquitinating enzyme that associates with p 97 to facilitate protein dislocation from the ER Citation (2009) (2)
A monoclonal antibody that causes the heterotrimeric G-protein G(o) to release its beta gamma subunits. (1996) (1)
Peptide Length and Sequence Specifidty of the Mouse TAPI/TAP2 Translocator By Ton N. M. Schumacher,* Devang V. Kantesaria,* (1994) (1)
Peptide vinyl sulfones : inhibitors and active site probes for the study of proteasome function in vivo (1997) (1)
Nobel Prize: A dark edge to the glory (2012) (1)
Protein quality control in the ER: balancing the ubiquitin chequebook (2013) (1)
Title Enzymatic blockade of the ubiquitin-proteasome pathway (2011) (1)
Abstract A82: Direct and indirect regulators of epithelial-to-mesenchymal transition mediated immunosuppression in breast carcinomas (2020) (1)
Antigen discovery tools for adaptive immune receptor repertoire research. (2020) (1)
BAT 3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum Citation Claessen (2011) (1)
Tight metabolic coupling of the proteasome with downstream oligopeptidases. (1999) (1)
Structural and sequence homologies between HLA-A and HLA-B antigens and immunoglobulins. (1979) (1)
Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides (2020) (1)
A feline class II alpha gene with striking similarity to the HLA-DPA pseudogene. (1988) (1)
Author response: How lamina-associated polypeptide 1 (LAP1) activates Torsin (2014) (1)
Faculty Opinions recommendation of Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality. (2014) (1)
A Luman/CREB3–ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens (2014) (1)
Preface (2001) (1)
Structural studies of the membrane-associated products of the human major histocompatibility complex. (1980) (1)
Human histocompatibility antigens. (1983) (1)
Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms (2022) (1)
Noninvasive Immuno-PET Imaging of CD8+ T Cell Behavior in Influenza A Virus-Infected Mice (2021) (1)
Making and Breaking Peptide Bonds: Protein Engineering Using Sortase (2011) (1)
Primary Dendritic Cells Multiple Endolysosomal Membrane Proteins Is Microtubule Dependent and Involves Tubulation of Class II MHC Compartments (2007) (1)
NATIVE: Nanobody-assisted tissue immunostaining for volumetric EM (2018) (1)
Obituary: Jacques H. van Boom (1937–2004) (2004) (1)
Immunology. MHC class II dimer of dimers. (1993) (1)
Antigen presentation. DM exchange mechanism. (1995) (1)
An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance (2021) (1)
Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity (2020) (1)
Title Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP 5 / ROP 18 allelic combination Permalink (2015) (1)
Complete Primary Structure of Human Histocompatibility Antigen HLA-B7 (1981) (1)
PD-L1 is an activation-independent marker of brown adipocytes (2017) (1)
Correction for Jailkhani et al., Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix (2019) (1)
623 Immuno-STATs: Leveraging protein engineering to expand and track antigen-specific T cells in vivo (2020) (1)
Cell surface and extracellular glycoconjugates: Structure and function: edited by D.D. Roberts and R.P. Mecham, Academic Press, 1993. £62.00 (xii + 314 pages) ISBN 012 5896301 (1994) (1)
Interactions Cells by MHC Class II-Dependent Zwitterionic Polysaccharides Stimulate T (2002) (1)
Ultrastructural localization of melanoma-associated antigen detected by monoclonal antibody NKI/C-3 (1987) (1)
Retrograde Transport from the Golgi Region to the Endoplasmic Reticulum Is Sensitive to GTPyS (2002) (1)
A new MHC locus that influences class I peptide presentation. (1999) (1)
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T-cells. (2023) (0)
Qa-2–dependent Selection of CD8 a/a T Cell Receptor a/b 1 Cells in Murine Intestinal Intraepithelial Lymphocytes (2000) (0)
Subsets the TCR in Development of iNKT Functional Reveal a Role for Both Tissue of Origin and Monoclonal Invariant NKT ( iNKT ) Cell Mice (2017) (0)
Watching Class II MHC molecules move (2003) (0)
Sa.130. HLA-DR+ CD4+ T-Cells Have the Capacity to Present Endogenous Antigen (2006) (0)
PNAS Plus Significance Statements (2015) (0)
The IL-2 Induced De-Ubiquitinating Enzyme, DUB-2, Is a Nuclear-Cytoplasmic Shuttle Which Requires Catalytic Activity for Nuclear Localization. (2006) (0)
Crystal structure of an ASC binding nanobody (2016) (0)
Preface (2012) (0)
P599 - Reactivity and specificity of CD8+ T cells in MHC class I deficient mice (1996) (0)
Adaptive immunity mediated by Natural Killer cells. (45.20) (2012) (0)
Translation to Stress Responses in Saccharomyces cerevisiae (2014) (0)
Editorial overview. (2009) (0)
Increase in Positive Selection of CD8 + T Cells in TAPl-Mutant Mice by Human/~2-Microgl obulln Transgene By Hisse Martien van Santen,* Aaron Woolsey,* (1995) (0)
Imaging Human Immune Cell Infiltration in a Xenograft Graft-Versus-Host Disease Model (2016) (0)
Running Title: TMD interactions required for MHCI dislocation (2003) (0)
Abstract B149: Real-time analysis of cell membrane protein and virus internalization using site-specific conjugation of protease-sensitive probes (2019) (0)
A mouse cytomegalovirus glycoprotein , gp 34 , forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface ing presentation of peptide by MHC class I molecules (2013) (0)
Correction to Supporting Information for Rashidian et al., Noninvasive imaging of immune responses (2018) (0)
Obituary Johannes J. ("Jon") van Rood (2018) (0)
S14.5 RAB proteins inlymnaea stagnalis (1993) (0)
Assembly and Intracellular Targeting of the (cid:98)(cid:103) Subunits of Heterotrimeric G Proteins (1997) (0)
Abstract B080: Noninvasive imaging of antitumor responses as a possible predictive tool (2016) (0)
Single domain antibody-antigen adducts that target Class II MHC induce antigen-specific tolerance (2021) (0)
Listeria monocytogenes Immunity Against T Cell-Mediated Protective + Generate CD8 Class Ia MHC-Deficient BALB/c Mice (2017) (0)
Engineered E. coli for the targeted deposition of therapeutic payloads to sites of disease (2022) (0)
Abstract B112: Targeting immunotherapy to the tumor microenvironment using anti-PDL1 VHH (2016) (0)
Evidence for a repressor controlling the transcription of hla class i genes in small cellular lung carcinoma (1988) (0)
Huib Ovaa (1973–2020) (2020) (0)
Haplotype-specific Use of Lysosomal Proteases Can Modulate the Class II MHC Peptide Repertoire but Does Not Impair Invariant Chain Degradation in Human Antigen Presenting Cells (2007) (0)
LSTc-bearing decoys capture influenza virus 1 (2013) (0)
UL36 Deubiquitinylating Peptidase (2013) (0)
VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 (2017) (0)
Hidde Ploegh: immunologist, journeyman. Interview by Nicole LeBrasseur. (2007) (0)
Abstract B75: Transnuclear mice from pancreatic tumor-infiltrating T cells. (2012) (0)
Identification of Plasmodium berghei novel liver stage CD8 T cell epitopes by caged MHC class I tetramer technology (43.30) (2012) (0)
Receptor-1 A New Role for Murine Cytomegalovirus Fc Viral Interference with B 7-1 Costimulation : (2006) (0)
Therapeutic blood detoxification via an immunoadsorptive fluidized bed (2000) (0)
Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo (2021) (0)
Targeted delivery of antigens to CD11b+ cells via nanobodies induces strong antigen-specific T cell and anti-tumor responses (2018) (0)
Quantity control of glycoprotein ERAD enhancers mediated by E2 in the ER (2015) (0)
The primary structure of a feline class I gene: Striking similarity toHLA-A (2006) (0)
Post‐Translational Modification: Specialized Applications (2000) (0)
18 Differential priming of T cells by antigens expressed in hepatocytes and cholangiocytes in animal models of autoimmune hepatitis and cholangitis (2006) (0)
APCsHeparan Sulfates and Glycoprotein 96 in Encephalomyelitis In Vivo Interact with Experimental Autoimmune Amino Acid Copolymers That Alleviate (2013) (0)
Toll-Like Receptor-Dependent Manner Compartments in Dendritic Cells in a T Cells Induce Extended Class II MHC (2003) (0)
Biochemistry of HLA-B27 in Transfected Cells and Transgenic Mice (1988) (0)
Immunology: A synthesis by Edward S. Golub, Sinauer Associates, Inc., 1987. £26.50 (xxii + 551 pages) ISBN 0 87893 268 2. (1988) (0)
Abstract B021: Single domain antibodies targeting CTLA-4 demonstrate a critical role for Fc in the antitumor response (2016) (0)
Abstract P2-07-01: EMT activates PERK-eIF2α signaling and sensitizes cells to perturbations in endoplasmic reticulum function (2015) (0)
Complete primary structure of human histocompatibility antigen HLA-B7: evolutionary and functional implications. (1980) (0)
Crystal Structure and Con formational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter Graphical (2016) (0)
Novel epitope derived from Plasmodium berghei liver-stage antigen induces a subset of protective CD8 T cells against sporozoite challenge (2018) (0)
Ubiquitin-specific Peptidases 14 and 6 (2013) (0)
During Biosynthesis Virus Superantigen with MHC Class II Association of Mouse Mammary Tumor (2013) (0)
Is a sulfated n linked glycan on lfa 3 involved in leukocyte function (1990) (0)
Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut. (2023) (0)
Abstract B59: Transnuclear mice as models of the immune response to pancreatic cancer (2015) (0)
Cytomegalovirus uses multiple strategies to interfere with MHC class I-restricted antigen presentation (1997) (0)
Solution structure of the ubiquitin domain N-terminal to the S27a ribosomal subunit of Giardia lamblia (2007) (0)
NanoTag Nanobody Tools for Drosophila In Vitro and In Vivo Studies (2022) (0)
A giant ubiquitin ligase (2021) (0)
Abstract B18: Noninvasive imaging of antitumor immune responses (2017) (0)
UNC93B1 Binding and Signaling Nucleotide-Sensing TLRs Are Important for Juxtamembrane Region of the Acidic Amino Acid Residues in the (2013) (0)
Machinery that guides immunity (2017) (0)
The cell biology of antigen presentation (book review) (2002) (0)
Crystal structure of mouse PD-L1 nanobody (2015) (0)
Quantitative Analysis of Cellular Diacylglycerol Content. (2014) (0)
Positron emission tomography to explore T cell responses in vivo (2022) (0)
anti-class II MHC VHH elicits focused a MUC 1 ( Tn ) immunity † (2017) (0)
APCs of Transgenic TLR9-GFP Mice Cell-Specific TLR9 Trafficking in Primary (2012) (0)
Crystal structure of UCHL3-UbVME complex (2004) (0)
Antigen presentation (SY4-2) Chairpersons: William Heath, Christian Münz (2010) (0)
The Role of N-Linked Carbohydrates in Antigen Presentation (1990) (0)
Erratum: The journal of experimental medicine (November 20, 2000) 192:10 (1521-1527) (2001) (0)
Journal club (2008) (0)
Major histocompatibility complex ( MHC ) class I KbDb 2 y 2 deficient mice possess functional CD 8 1 T cells and natural killer cells (1998) (0)
2016 NSMB Lu Li INCA Suppl (2016) (0)
A mouse monoclonal antibody against Alexa Fluor 647. (2014) (0)
University of Groningen Catch-and-Release Probes Applied to Semi-Intact Cells Reveal Ubiquitin-Specific Protease Expression in Chlamydia trachomatis Infection (2013) (0)
The Peptide Cargo of Class I Molecules: Not Just Passive Passengers (2007) (0)
A METHOD TO MEASURE MHC CLASS-I-PEPTIDE INTERACTIONS AT THE CELL-SURFACE (1990) (0)
VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 (2017) (0)
Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate (2007) (0)
VIRUS INTERACTIONS WITH IMMUNE SYSTEM (1999) (0)
Receptor-1A New Role for Murine Cytomegalovirus Fc Viral Interference with B7-1 Costimulation: (2006) (0)
Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME (2009) (0)
552 Discovery of an unexpected vulnerability of cancer stem-like cells via a functional dissection of EMT biology (2014) (0)
CD 8 [ superscript + ] T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2 K [ superscript b ]-Restricted MHV 68 Epitope Derived from gB-ORF 8 Help (2012) (0)
Immunoevasive Strategies: Host and Virus (2005) (0)
AntigenB Cell and T Cell Recognition of (2013) (0)
Books in brief (2012) (0)
A Functional Ubiquitin-Speciﬁc Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 Is Active during the Course of Infection (cid:1) (2007) (0)
Heterodimers Extracellularly like - Adapter for Generating Novel IL-12 Free IL-12p40 Monomer Is a Polyfunctional (2014) (0)
University of Groningen Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells Avalos, (2014) (0)
Chemical Modification of Azasugars, Inhibitors of N‐Glycoprotein‐ Processing Glycosidases and of HIV‐I Infection. Review and Structure‐ Activity Relationships (1993) (0)
Crystal Structure of Plasmodium falciparum Ubiquitin Carboxyl- terminal Hydrolase 3 (UCHL3) (2009) (0)
Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody (2016) (0)
ElaD Peptidase ( Escherichia coli ) (2013) (0)
Immune Tolerance by Red Cells (2020) (0)
HST.176 Cellular and Molecular Immunology, Fall 2002 (2002) (0)
Redundantly to Initiate Human Invariant Are Heterogeneously Expressed and Act Lysosomal Cysteine and Aspartic Proteases (2008) (0)
Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential (2023) (0)
Product by Its N-Terminal Proteolytic Cleavage Negative Self-Regulation of TLR9 Signaling (2014) (0)
Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC (2016) (0)
Localized and peripheral autoantibodies: evidence of humoral autoimmunity in patients with inclusion body myositis (159.21) (2012) (0)
Dendritic Cells Compartments in + Tubulation of Class II Requirements for T Cell-Polarized (2003) (0)
Synthesis of the Antibiotic 1,5-Dideoxy-1,5-imino-D-mannitol. (1989) (0)
Incorrect attribution of peptide source (1993) (0)
S.132. Cathepsin S Regulates MHC Class II Processing in Human CD4+HLA-DR+T Cells (2009) (0)
The Chaperone BAG 6 Captures Dislocated Glycoproteins in the Cytosol Citation Claessen (2014) (0)
Erratum: A new MHC locus that influences class I peptide presentation (Immunity (1997) 7 (641-651)) (1999) (0)
Synthesis of the Antibiotic 1,5-Dideoxy-1,5-imino-D-glucitol; Concomitant Formation of the D-Mannitol Analogue. (1988) (0)
Required for Cross-Priming In Vivo Myeloid Differentiation Factor 88 Is (2004) (0)
This information is current as Feedback Loop β Depends on an IFN-Murine B Cell Response to TLR 7 Ligands (2009) (0)
Improved GPCR ligands from nanobody tethering (2020) (0)
Suppression de reponse immunitaire par inhibition de cathepsine s (1997) (0)
Structure of the SecA-SecY complex with a translocating polypeptide substrate (2016) (0)
Preface (2005) (0)
The interest in various immunological subdisciplines waxes and wanes with every new discovery. Preface. (2014) (0)
Antigen presentation: immunologists co-opt cell biology. (1996) (0)
Cell biology of the B cell receptor (2014) (0)
Increase in Positive Selection o f C D 8 + T Cells in TAPl-Mutant Mice by Human / ~ 2-Microglobul ln Transgene By Hisse (2003) (0)
Gene conversion-like mechanisms may generate polymorphism in human class I genes. (1986) (0)
Site Other Than the Peptide Binding Groove Invariant Chain Can Bind MHC Class II at a (2013) (0)
Just Passive Passengers The Peptide Cargo of Class I Molecules: Not (2007) (0)
Improved GPCR Ligands Based on Genetically Impossible Nanobody-Peptide Fusions (2019) (0)
Crystal structure of a Murine MHC class I H2-Db molecule in complex with a photocleavable peptide (2008) (0)
CD 8 [ superscript + ] Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii (2011) (0)
Comparison of amino acid sequences of two human histocompatibility antigens , HLA-A 2 and HLA-B 7 : Location of putative alloantigenic sites ( protein structure / genetic polymorphism / alloantigenic determinants ) (0)
Faculty Opinions recommendation of Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD. (2014) (0)
The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent (2017) (0)
Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax (2001) (0)
Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure (2018) (0)
Membrane Mechanics of B Lymphocyte Activation (2009) (0)
Machinery that guides immunity. (2017) (0)
Table of Contents (1995) (0)
University of Groningen Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages Strijbis, (2013) (0)
Protein quality control in the endoplasmic reticulum (472.3) (2014) (0)
Abstract LB-336: Specific serine phosphorylation of IRE-1 controls enhanced splicing of XBP-1 and regulated IRE-1-dependent decay (RIDD) (2017) (0)
CD8[superscript +] T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2K[superscript b]-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection (2012) (0)
Faculty Opinions recommendation of Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. (2014) (0)
UNC 93 B 1 Binding and Signaling Nucleotide-Sensing TLRs Are Important for Juxtamembrane Region of the Acidic Amino Acid Residues in the (2013) (0)
Cryo-EM reconstruction of caspase-1 CARD (2016) (0)
Holliday junctions generate super-bright antibodies and antibody fragments in sortase-catalyzed reactions (2016) (0)
Editorial overview: Special section: Immunological engineering. (2015) (0)
Acidic residues in the juxta-transmembrane region of toll-like receptor 9 are crucial for binding UNC93B1 (68.12) (2012) (0)
A European slant on mol biol (2001) (0)
The CD8 T-Cell Response against Murine Gammaherpesvirus 68 Is Directed toward a Broad Repertoire of Epitopes from both Early and Late Antigens (cid:1) † (2008) (0)
Faculty Opinions recommendation of Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. (2014) (0)

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