Hideaki Hara
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Computer Science
Hideaki Hara's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Hideaki Hara's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A molecular chaperone inducer protects neurons from ER stress (2008) (241)
- The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties (2008) (231)
- Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia (2010) (227)
- Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light (2014) (212)
- Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. (2007) (207)
- Comparison of bee products based on assays of antioxidant capacities (2009) (198)
- Neuroprotective Effect of Recombinant Human Granulocyte Colony-Stimulating Factor in Transient Focal Ischemia of Mice (2006) (186)
- BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer (2006) (162)
- Vitreous fluid levels of β-amyloid(1–42) and tau in patients with retinal diseases (2005) (160)
- On–off system for PI3-kinase–Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN) (2011) (146)
- Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. (2004) (143)
- Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone) (2017) (143)
- Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. (2011) (133)
- Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage (2005) (128)
- Involvement of ER stress in retinal cell death (2007) (127)
- Neuroprotection by Brazilian Green Propolis against In vitro and In vivo Ischemic Neuronal Damage (2005) (117)
- Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice (2009) (116)
- The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment (2013) (113)
- Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye. (2009) (113)
- Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells (2009) (111)
- The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis (2012) (103)
- Interleukin-1β mediates ischemic injury in the rat retina (2001) (102)
- Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis (2013) (99)
- Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo (2008) (96)
- Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. (2009) (96)
- Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema (2010) (95)
- Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons (2007) (95)
- Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice (2007) (92)
- Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells (2009) (90)
- Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. (2013) (90)
- 10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells (2007) (90)
- Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina. (2000) (89)
- Laxative effects of agarwood on low-fiber diet-induced constipation in rats (2010) (88)
- Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. (2009) (86)
- Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. (2001) (83)
- Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells. (2008) (80)
- Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia (2012) (79)
- SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models (2014) (77)
- Agarwood Induced Laxative Effects via Acetylcholine Receptors on Loperamide-Induced Constipation in Mice (2010) (76)
- New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents. (2003) (76)
- 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of bee products and their constituents determined by ESR. (2009) (75)
- Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil (2008) (74)
- Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke (2013) (74)
- Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. (2009) (74)
- Phosphodiesterase-III Inhibitor Prevents Hemorrhagic Transformation Induced by Focal Cerebral Ischemia in Mice Treated with tPA (2010) (73)
- Essential Role of Neuron-Enriched Diacylglycerol Kinase (DGK), DGKβ in Neurite Spine Formation, Contributing to Cognitive Function (2010) (73)
- Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo. (2008) (72)
- Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress. (2011) (72)
- Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina (2002) (72)
- Diacylglycerol Kinase β Knockout Mice Exhibit Lithium-Sensitive Behavioral Abnormalities (2010) (70)
- Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage (2005) (70)
- Reduced retinal function in amyloid precursor protein‐over‐expressing transgenic mice via attenuating glutamate‐N‐methyl‐d‐aspartate receptor signaling (2008) (69)
- Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice (2010) (69)
- Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration. (2010) (69)
- Brazilian Green Propolis Protects against Retinal Damage In Vitro and In Vivo (2006) (69)
- Interleukin-1beta mediates ischemic injury in the rat retina. (2001) (69)
- Antihypertensive effects of flavonoids isolated from brazilian green propolis in spontaneously hypertensive rats. (2009) (67)
- The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model (2012) (67)
- Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys. (2009) (66)
- Inhibitory actions of bilberry anthocyanidins on angiogenesis (2010) (64)
- Edaravone, a Free Radical Scavenger, Protects against Retinal Damage in Vitro and in Vivo (2009) (64)
- Role of endoplasmic reticulum stress in light‐induced photoreceptor degeneration in mice (2013) (62)
- Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice. (2012) (62)
- Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil (2008) (60)
- Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina. (2010) (59)
- Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body (2010) (59)
- Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo. (2011) (59)
- Analysis of the Interaction between Clopidogrel, Aspirin, and Proton Pump Inhibitors Using the FDA Adverse Event Reporting System Database. (2015) (57)
- Laxative Effect of Agarwood Leaves and Its Mechanism (2008) (57)
- An Inducer of VGF Protects Cells against ER Stress-Induced Cell Death and Prolongs Survival in the Mutant SOD1 Animal Models of Familial ALS (2010) (57)
- Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress (2006) (57)
- Purple Rice (Oryza sativa L.) Extract and its Constituents Inhibit VEGF‐induced Angiogenesis (2012) (56)
- Nrf2 protects photoreceptor cells from photo‐oxidative stress induced by blue light (2017) (56)
- A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice (2008) (55)
- Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro (2014) (55)
- Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy. (2008) (54)
- Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in‐vitro and in mice in‐vivo (2008) (53)
- Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage. (2011) (53)
- Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury. (2014) (53)
- Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen‐glucose deprivation Stress, with a gene‐expression analysis (2009) (52)
- Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice. (2011) (50)
- Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo (2007) (50)
- Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage (2019) (50)
- Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. (2008) (50)
- Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage. (2007) (49)
- Diabetes Mellitus Aggravates Hemorrhagic Transformation after Ischemic Stroke via Mitochondrial Defects Leading to Endothelial Apoptosis (2014) (48)
- Prostanoids in the therapy of glaucoma. (2006) (48)
- Progranulin, a Major Secreted Protein of Mouse Adipose‐Derived Stem Cells, Inhibits Light‐Induced Retinal Degeneration (2014) (47)
- Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation. (2012) (47)
- Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database (2016) (46)
- Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina. (2011) (46)
- A Novel Calpain Inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic Acid 5-Methoxy-3-oxapentyl Ester (SNJ-1945), Reduces Murine Retinal Cell Death In Vitro and In Vivo (2010) (46)
- Mild Endoplasmic Reticulum Stress Promotes Retinal Neovascularization via Induction of BiP/GRP78 (2013) (45)
- Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice. (2012) (45)
- Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth Factor in the Brain (2012) (45)
- Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. (2013) (44)
- Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models (2016) (44)
- An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation (2012) (43)
- Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice (2018) (43)
- The Involvement of the Oxidative Stress in Murine Blue LED Light-Induced Retinal Damage Model. (2017) (43)
- Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia (2007) (42)
- Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage (2009) (42)
- Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve. (2006) (42)
- Topiramate reduces excitotoxic and ischemic injury in the rat retina (2003) (41)
- Protective effects of a dietary carotenoid, astaxanthin, against light-induced retinal damage. (2013) (41)
- Induction of amyloid-β1-42 in the retina and optic nerve head of chronic ocular hypertensive monkeys (2012) (41)
- Zeaxanthin, a Retinal Carotenoid, Protects Retinal Cells against Oxidative Stress (2009) (41)
- Morphological and Functional Changes in the Retina after Chronic Oxygen-Induced Retinopathy (2012) (41)
- Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: a novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative (2004) (40)
- Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation. (2018) (40)
- A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice (2016) (40)
- Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain (2006) (40)
- Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis (2010) (39)
- The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. (2013) (39)
- Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism. (2017) (38)
- Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration. (2017) (38)
- Intravitreal injection of endothelin-1 caused optic nerve damage following to ocular hypoperfusion in rabbits. (2006) (37)
- Morphometric evaluation of changes with time in optic disc structure and thickness of retinal nerve fibre layer in chronic ocular hypertensive monkeys. (2004) (37)
- Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice (2015) (37)
- Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. (2006) (37)
- Fasudil and Ozagrel in Combination Show Neuroprotective Effects on Cerebral Infarction after Murine Middle Cerebral Artery Occlusion (2011) (37)
- Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice (2010) (37)
- Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-κB and spleen tyrosine kinase activation. (2013) (37)
- Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier (2017) (37)
- Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation (2011) (36)
- Increased Expression of Tight Junctions in ARPE-19 Cells Under Endoplasmic Reticulum Stress (2011) (36)
- The Protective Effect and Action Mechanism of Vaccinium myrtillus L. on Gastric Ulcer in Mice (2011) (36)
- Modulation of endoplasmic reticulum stress in Parkinson's disease. (2015) (35)
- Generation and Characterization of Conditional Heparin-Binding EGF-Like Growth Factor Knockout Mice (2009) (34)
- Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase (2016) (34)
- The roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice. (2014) (34)
- Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels (2011) (34)
- Systemic Simvastatin Rescues Retinal Ganglion Cells from Optic Nerve Injury Possibly through Suppression of Astroglial NF-κB Activation (2014) (34)
- A pharmacological approach in newly established retinal vein occlusion model (2017) (34)
- Oxidative Stress in Retinal Diseases (2017) (33)
- Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation (2016) (33)
- Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt. (2010) (32)
- Induction of amyloid precursor protein by the neurotoxic peptide, amyloid‐beta 25–35, causes retinal ganglion cell death (2010) (32)
- Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice. (2017) (32)
- Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice (2008) (31)
- A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase (2018) (30)
- Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system (2017) (30)
- Calpain Inhibitor Protects Cells against Light-Induced Retinal Degeneration (2010) (30)
- Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia (2009) (30)
- Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo. (2016) (30)
- Established Stem Cell Model of Spinal Muscular Atrophy Is Applicable in the Evaluation of the Efficacy of Thyrotropin‐Releasing Hormone Analog (2016) (29)
- Molecular imaging reveals unique degenerative changes in experimental glaucoma (2009) (29)
- Diacylglycerol Kinase β Knockout Mice Exhibit Attention-Deficit Behavior and an Abnormal Response on Methylphenidate-Induced Hyperactivity (2012) (29)
- Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase (2011) (29)
- Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival (2018) (28)
- Glucagon-like peptide-1 protects the murine hippocampus against stressors via Akt and ERK1/2 signaling. (2015) (28)
- Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice (2009) (28)
- Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2 (2006) (28)
- Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. (2015) (28)
- RS9, a novel Nrf2 activator, attenuates light‐induced death of cells of photoreceptor cells and Müller glia cells (2017) (28)
- Continuous monitoring of circadian variations in intraocular pressure by telemetry system throughout a 12-week treatment with timolol maleate in rabbits. (2005) (28)
- Combination Treatment with Normobaric Hyperoxia and Cilostazol Protects Mice against Focal Cerebral Ischemia-Induced Neuronal Damage Better Than Each Treatment Alone (2009) (28)
- The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photoreceptor cell damage in vitro. (2013) (28)
- Glucocorticoid Modulatory Element-binding Protein 1 Binds to Initiator Procaspases and Inhibits Ischemia-induced Apoptosis and Neuronal Injury* (2006) (27)
- Apoptosis‐Inducing Factor and Cyclophilin A Cotranslocate to the Motor Neuronal Nuclei in Amyotrophic Lateral Sclerosis Model Mice (2011) (27)
- Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice (2008) (27)
- Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation (2015) (27)
- New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice. (2007) (27)
- Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model (2011) (27)
- Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits. (2001) (26)
- Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells (2015) (26)
- Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis (2015) (26)
- Tissue Kallikrein Inhibits Retinal Neovascularization via the Cleavage of Vascular Endothelial Growth Factor-165 (2011) (26)
- Involvement of Bid and caspase‐2 in endoplasmic reticulum stress‐ and oxidative stress‐induced retinal ganglion cell death (2011) (26)
- Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves. (2012) (26)
- Involvement of Toll-like receptors in ischemia-induced neuronal damage. (2011) (25)
- Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury (2011) (25)
- Piezo channel plays a part in retinal ganglion cell damage. (2019) (25)
- Imipramine protects mouse hippocampus against tunicamycin-induced cell death. (2012) (25)
- Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo. (2015) (25)
- Effects of ticagrelor in a mouse model of ischemic stroke (2017) (25)
- Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease (2008) (24)
- Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. (2006) (24)
- Protective effects of cilostazol against hemorrhagic stroke: Current and future perspectives. (2016) (24)
- GPNMB ameliorates mutant TDP‐43‐induced motor neuron cell death (2017) (24)
- Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina (2016) (24)
- Protective Effects of Astaxanthin from Paracoccus carotinifaciens on Murine Gastric Ulcer Models (2012) (24)
- Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice. (2012) (23)
- Stevens-Johnson syndrome and toxic epidermal necrolysis: the Food and Drug Administration adverse event reporting system, 2004-2013. (2015) (23)
- Identification of Phenolic Compounds in Aquilaria crassna Leaves Via Liquid Chromatography-Electrospray Ionization Mass Spectroscopy (2012) (23)
- TUDCA Promotes Phagocytosis by Retinal Pigment Epithelium via MerTK Activation. (2015) (23)
- Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury (2018) (23)
- Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients (2009) (23)
- Angiostatic effects of Brazilian green propolis and its chemical constituents. (2010) (23)
- AN EXPERIMENTAL MODEL OF MIGRAINE WITH AURA: CORTICAL HYPOPERFUSION FOLLOWING SPREADING DEPRESSION IN THE AWAKE AND FREELY MOVING RAT (1996) (23)
- A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N‐methyl‐D‐aspartate injection and ischemia–reperfusion (2009) (23)
- Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy. (2006) (23)
- Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides. (2009) (23)
- Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. (2006) (22)
- Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. (2010) (22)
- A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. (2013) (22)
- The antianxiety‐like effect of astaxanthin extracted from Paracoccus carotinifaciens (2011) (22)
- Progranulin deficiency causes the retinal ganglion cell loss during development (2017) (22)
- Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo. (2006) (22)
- The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts. (2018) (22)
- Pharmacologically Distinctive Behaviors other than Burying Marbles during the Marble Burying Test in Mice (2010) (22)
- Effects of topically instilled bunazosin, an alpha1-adrenoceptor antagonist, on constrictions induced by phenylephrine and ET-1 in rabbit retinal arteries. (2004) (21)
- The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe (2015) (20)
- Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF (2017) (20)
- Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity. (2007) (20)
- Protective effects of placental growth factor on retinal neuronal cell damage (2014) (20)
- Sulfatides, L- and P-selectin ligands, exacerbate the intimal hyperplasia occurring after endothelial injury. (2005) (20)
- The potential roles of metallothionein as a therapeutic target for cerebral ischemia and retinal diseases. (2013) (20)
- Laxative effects and mechanism of action of Brazilian green propolis (2012) (20)
- The Effects of Brazilian Green Propolis against Excessive Light-Induced Cell Damage in Retina and Fibroblast Cells (2013) (20)
- Discovery of a CNS penetrant small molecule SMN2 splicing modulator with improved tolerability for spinal muscular atrophy (2020) (20)
- Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells‐derived disease model (2017) (19)
- Agarwood (Aquilaria Crassna) Extracts Decrease High-protein High-fat Diet-induced Intestinal Putrefaction Toxins in Mice (2012) (19)
- Dual effects of interleukin-1β on N-methyl-d-aspartate-induced retinal neuronal death in rat eyes (2001) (19)
- Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation. (2018) (19)
- Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo. (2013) (19)
- ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis (2013) (19)
- Editorial: Drug Repositioning: Current Advances and Future Perspectives (2018) (19)
- Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others (2017) (19)
- Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems (2019) (19)
- Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage (2021) (19)
- Involvement of endoplasmic reticulum stress in optic nerve degeneration following N‐methyl‐D‐aspartate‐induced retinal damage in mice (2012) (18)
- Crocetin Prevents Amyloid β 1-42 -Induced Cell Death in Murine Hippocampal Cells (2014) (18)
- Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line (2018) (18)
- Edaravone is a free radical scavenger that protects against laser-induced choroidal neovascularization in mice and common marmosets. (2016) (18)
- Hydroxyl radicals cause fluctuation in intracellular ferrous ion levels upon light exposure during photoreceptor cell death. (2014) (18)
- Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization. (2017) (18)
- Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability. (2019) (18)
- SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells. (2012) (18)
- Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression. (2012) (18)
- Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice. (2015) (17)
- Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice. (2014) (17)
- Comparison of the therapeutic indexes of different molecular forms of botulinum toxin type A. (2005) (17)
- Effect of lomerizine, a new Ca(2+)channel blocker, on the microcirculation in the optic nerve head in conscious rabbits: a study using a laser speckle technique. (1999) (17)
- Effect of hypoxia on susceptibility of RGC-5 cells to nitric oxide. (2010) (17)
- Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo. (2012) (17)
- The Protective Effects of Levetiracetam on a Human iPSCs-Derived Spinal Muscular Atrophy Model (2019) (17)
- Enzymatic resolution and evaluation of enantiomers of cis-5'-hydroxythalidomide. (2008) (17)
- CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure (2017) (17)
- Propofol Exerts Greater Neuroprotection with Disodium Edetate than without It (2008) (16)
- Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase. (2016) (16)
- Neuroprotective effects of β-secretase inhibitors against rat retinal ganglion cell death (2004) (16)
- Automated experimental system capturing three behavioral components during murine forced swim test. (2011) (16)
- Involvement of brain-derived neurotrophic factor in time-dependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate (2009) (16)
- Metallothionein-III deficiency exacerbates light-induced retinal degeneration. (2012) (16)
- A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death (2018) (16)
- Adenosine protects cultured retinal neurons against NMDA-induced cell death through A1 receptors (2004) (15)
- Cilostazol Ameliorates Warfarin-Induced Hemorrhagic Transformation After Cerebral Ischemia in Mice (2013) (15)
- VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush (2018) (15)
- Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization (2018) (15)
- The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage (2020) (15)
- Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models (2020) (14)
- Bimatoprost protects retinal neuronal damage via Akt pathway. (2013) (14)
- Brain-derived neurotrophic factor inhibits changes in soma-size of retinal ganglion cells following optic nerve axotomy in rats. (2002) (14)
- A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner. (2020) (14)
- Lomerizine, a Ca2+ Channel Blocker, Protects against Neuronal Degeneration within the Visual Center of the Brain after Retinal Damage in Mice (2010) (14)
- Novel situations of endothelial injury in stroke--mechanisms of stroke and strategy of drug development: protective effects of antiplatelet agents against stroke. (2011) (14)
- Fate of graft cells: what should be clarified for development of mesenchymal stem cell therapy for ischemic stroke? (2014) (14)
- Acidic stress-ER stress axis for blunted activation of NF-κB in mesothelial cells exposed to peritoneal dialysis fluid. (2012) (14)
- Phosphatidylinositol inhibits vascular endothelial growth factor-A--induced migration of human umbilical vein endothelial cells. (2008) (14)
- Protective effects of NSP-116, a novel imidazolyl aniline derivative, against light-induced retinal damage in vitro and in vivo. (2016) (14)
- Riluzole enhances the antitumor effects of temozolomide via suppression of MGMT expression in glioblastoma. (2020) (14)
- Effect of chitosan chewing gum on reducing serum phosphorus in hemodialysis patients: a multi-center, randomized, double-blind, placebo-controlled trial (2014) (14)
- A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models. (2019) (14)
- Blockade of phosphodiesterase-III protects against oxygen-glucose deprivation in endothelial cells by upregulation of VE-cadherin. (2011) (14)
- Analysis and characterization of anthocyanins and carotenoids in Japanese blue tomato (2016) (13)
- Effects of ripasudil, a ROCK inhibitor, on retinal edema and nonperfusion area in a retinal vein occlusion murine model. (2018) (13)
- The extracellular fragment of GPNMB (Glycoprotein nonmelanosoma protein B, osteoactivin) improves memory and increases hippocampal GluA1 levels in mice (2015) (13)
- Colored lenses suppress blue light-emitting diode light-induced damage in photoreceptor-derived cells (2016) (13)
- Memantine Protects Against Secondary Neuronal Degeneration in Lateral Geniculate Nucleus and Superior Colliculus after Retinal Damage in Mice (2008) (13)
- Involvement of diacylglycerol kinase β in the spine formation at distal dendrites of striatal medium spiny neurons (2015) (12)
- The kallikrein system in retinal damage/protection. (2015) (12)
- VGF and striatal cell damage in in vitro and in vivo models of Huntington’s disease (2015) (12)
- Clinical significance of glycoprotein nonmetastatic B and its association with HER2 in breast cancer (2015) (12)
- Increased Seizure Susceptibility in a Mouse with Diacylglycerol Kinase β Deficiency (2013) (12)
- Triamcinolone Acetonide Suppresses Inflammation and Facilitates Vascular Barrier Function in Human Retinal Microvascular Endothelial Cells. (2017) (12)
- [Evaluation of the association between the use of oral anti-hyperglycemic agents and hypoglycemia in Japan by data mining of the Japanese Adverse Drug Event Report (JADER) database]. (2014) (12)
- Contraceptives as possible risk factors for postpartum depression: A retrospective study of the food and drug administration adverse event reporting system, 2004–2015 (2018) (12)
- Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops. (2011) (12)
- Establishment of the ocular hypertension model using the common marmoset. (2013) (12)
- Involvement of endoplasmic reticulum stress in optic nerve degeneration after chronic high intraocular pressure in DBA/2J mice (2015) (12)
- Role of heparin-binding epidermal growth factor-like growth factor in light-induced photoreceptor degeneration in mouse retina. (2013) (12)
- Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma. (2020) (12)
- Movement of retinal vessels toward the optic nerve head after increasing intraocular pressure in monkey eyes with experimental glaucoma (2017) (12)
- Neutrophil accumulation promotes intimal hyperplasia after photochemically induced arterial injury in mice. (2005) (12)
- Alterations in neurofilament light in optic nerve in rat kainate and monkey ocular hypertension models (2004) (11)
- Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases (2016) (11)
- Microarray analysis of the liver in metallothionein-III null mice treated with cadmium. (2010) (11)
- Rifampicin inhibits the retinal neovascularization in vitro and in vivo. (2008) (11)
- Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma (2020) (11)
- Attenuation of cadmium-induced testicular injury in metallothionein-III null mice. (2010) (11)
- Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy. (2020) (11)
- Excess adiponectin in eyes with progressive ocular vascular diseases (2021) (11)
- Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion. (2018) (11)
- Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma (2013) (10)
- Effects of Bunazosin Hydrochloride on Ciliary Muscle Constriction and Matrix Metalloproteinase Activities (2004) (10)
- Effects of kallidinogenase on retinal edema and size of non-perfused areas in mice with retinal vein occlusion. (2017) (10)
- Tissue kallikrein (kallidinogenase) protects against retinal ischemic damage in mice. (2014) (10)
- The involvement of ATF4 and S-opsin in retinal photoreceptor cell damage induced by blue LED light (2017) (10)
- GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response (2017) (10)
- VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models (2019) (10)
- New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells. (2004) (10)
- EP300 Protects from Light-Induced Retinopathy in Zebrafish (2016) (10)
- Cilostazol prevents retinal ischemic damage partly via inhibition of tumor necrosis factor-α-induced nuclear factor-kappa B/activator protein-1 signaling pathway (2013) (10)
- Protective Effect of Bendavia (SS-31) Against Oxygen/Glucose-Deprivation Stress-Induced Mitochondrial Damage in Human Brain Microvascular Endothelial Cells. (2017) (10)
- Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish. (2016) (9)
- Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells (2021) (9)
- CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo. (2009) (9)
- Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis (2019) (9)
- Microglia increases the proliferation of retinal precursor cells during postnatal development (2018) (9)
- Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model. (2020) (9)
- Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properties (2007) (9)
- An automated evaluation system for analyzing antinociceptive effects on intracolonic capsaicin-induced visceral pain-related licking behavior in mice. (2011) (9)
- Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-D-aspartate-induced retinal damage model. (2013) (9)
- Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury (2004) (8)
- Efficacy of Prednisolone in Generated Myotubes Derived From Fibroblasts of Duchenne Muscular Dystrophy Patients (2018) (8)
- Impairment of oligodendrocyte lineages in spinal muscular atrophy model systems (2019) (8)
- Involvement of cannabinoid receptor type 2 in light‐induced degeneration of cells from mouse retinal cell line in vitro and mouse photoreceptors in vivo (2018) (8)
- Temozolomide has anti-tumor effects through the phosphorylation of cPLA2 on glioblastoma cells (2019) (8)
- Canine SOD1 harboring E40K or T18S mutations promotes protein aggregation without reducing the global structural stability (2020) (8)
- Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys. (2004) (8)
- SUN N8075, a novel radical scavenger, protects against retinal cell death in mice (2011) (8)
- Restraint-Induced Expression of Endoplasmic Reticulum Stress-Related Genes in the Mouse Brain (2011) (8)
- Oral and ocular administration of crocetin prevents retinal edema in a murine retinal vein occlusion model (2019) (8)
- In Models of Intracerebral Hemorrhage, Rivaroxaban is Superior to Warfarin to Limit Blood Brain Barrier Disruption and Hematoma Expansion. (2017) (7)
- Granulin 1 Promotes Retinal Regeneration in Zebrafish (2018) (7)
- Topical Diclofenac-Loaded Liposomes Ameliorate Laser-Induced Choroidal Neovascularization in Mice and Non-Human Primates. (2017) (7)
- Levetiracetam, an Antiepileptic Drug has Neuroprotective Effects on Intracranial Hemorrhage Injury (2020) (7)
- Role of metallothioneins 1 and 2 in ocular neovascularization. (2014) (7)
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice. (2019) (7)
- Contribution of platelet-derived growth factor signaling to retina regeneration in zebrafish (2020) (7)
- An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization. (2011) (7)
- Memantine, an NMDA receptor antagonist, improves working memory deficits in DGKβ knockout mice (2016) (7)
- Effects of roscovitine, a cell cycling-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage (2013) (7)
- Neuroprotective Effect of Ocular Hypotensive Drugs: Latanoprost/Timolol in Combination Are More Effective than Each as Monotherapy in RGC-5. (2016) (7)
- Rimonabant, a selective cannabinoid1 receptor antagonist, protects against light‐induced retinal degeneration in vitro and in vivo (2017) (7)
- Impaired Cerebellar Development in Mice Overexpressing VGF (2018) (7)
- Effects of timolol-related ophthalmic solutions on cultured human conjunctival cells (2010) (7)
- Optic cup enlargement followed by reduced optic nerve head circulation after optic nerve stimulation. (2001) (6)
- Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation (2021) (6)
- Relationship between Elevated Intraocular Pressure and Divided Peripapillary Sector Retinal Nerve Fiber Layer Thickness in a Cynomolgus Monkey Laser-Induced Ocular Hypertension Model (2017) (6)
- Protective effects of fluoroquinolones on UV‐induced damage of cultured ocular cell lines (2017) (6)
- Overcoming Obstacles to Drug Repositioning in Japan (2017) (6)
- Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis. (2021) (6)
- Synthesis of the Highly Potent Prostanoid FP Receptor Agonist, AFP-168: A Novel 15-Deoxy-15,15-difluoroprostaglandin F2α Derivative. (2004) (6)
- Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice (2010) (6)
- Effects of progranulin on the pathological conditions in experimental myocardial infarction model (2020) (6)
- Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice (2019) (6)
- Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro. (2019) (6)
- [Protective effects of cilostazol against transient focal cerebral ischemia and hemorrhagic transformation]. (2011) (6)
- Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells. (2020) (6)
- Nerve Fiber Layer Measurement Using Scanning Laser Polarimetry with Fixed Corneal Compensator in Normal Cynomolgus Monkey Eyes (2005) (5)
- Anti-vascular endothelial growth factor antibody limits vascular leakage and decreases subretinal fibrosis in a cynomolgus monkey choroidal neovascularization model. (2020) (5)
- An experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset. (2015) (5)
- The phosphodiesterase III inhibitor cilostazol ameliorates ethanolinduced endothelial dysfunction. (2014) (5)
- Platelet-Derived Growth Factor-BB Lessens Light-Induced Rod Photoreceptor Damage in Mice. (2017) (5)
- Effects of Topically Instilled Bunazosin Hydrochloride and Other Ocular Hypotensive Drugs on Endothelin-1-induced Constriction in Rabbit Retinal Arteries (2004) (5)
- Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures (2004) (5)
- Sensorimotor gating deficits and effects of antipsychotics on the hyperactivity in VGF-overexpressing mice. (2018) (5)
- Piezo 1 is involved in intraocular pressure regulation. (2021) (5)
- Activation of the unfolded protein response in canine degenerative myelopathy (2018) (5)
- Fermented Rice Germ Extract Alleviates Morphological and Functional Damage to Murine Gastrocnemius Muscle by Inactivation of AMP-Activated Protein Kinase. (2017) (5)
- Pro-inflammatory cytokines suppress HYBID (hyaluronan (HA) -binding protein involved in HA depolymerization/KIAA1199/CEMIP) -mediated HA metabolism in human skin fibroblasts. (2021) (5)
- HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth (2021) (4)
- [A molecular chaperone inducer as potential therapeutic agent for neurodegenerative disease]. (2007) (4)
- Lipid Droplet Accumulation Promotes RPE Dysfunction (2022) (4)
- Pharmacological inhibition of mitochondrial fission attenuates oxidative stress-induced damage of retinal pigmented epithelial cells. (2021) (4)
- The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment (2013) (4)
- A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optical coherence tomography (2021) (4)
- Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery (2012) (4)
- Progranulin increases phagocytosis by retinal pigment epithelial cells in culture (2017) (4)
- シンポジウム06―3 脳血管障害治療の次のブレークスルーを目指して The involvement of endoplasmic reticulum stress in pathogenesis after cerebral ischemia (2010) (4)
- Treatment with GDF15, a TGFβ superfamily protein, induces protective effect on retinal ganglion cells. (2020) (4)
- Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae. (2020) (4)
- Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration (2019) (4)
- ANKFY1 is essential for retinal endothelial cell proliferation and migration via VEGFR2/Akt/eNOS pathway. (2020) (4)
- Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice. (2021) (3)
- Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin. (2021) (3)
- Tissue plasminogen activator prevents restoration of tight junction proteins through upregulation of angiopoietin-2. (2013) (3)
- Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by l-glutamate and tunicamycin. (2021) (3)
- NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells (2022) (3)
- Evaluation of Bleb Characteristics after Trabeculectomy and Glaucoma Implant Surgery in the Rabbit (2020) (3)
- Physiological Roles of Metallothioneins in Central Nervous System Diseases. (2018) (3)
- REVIEW: An Approach for Neuroprotective Therapies of Secondary Brain Damage after Excitotoxic Retinal Injury in Mice (2010) (3)
- The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice (2017) (3)
- Intravitreal aflibercept protects photoreceptors of mice against excessive light exposure. (2018) (3)
- Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion. (2021) (3)
- The Changes in Blood Flow Seen in the Eye after Foot Acupuncture Treatment in Mice (2020) (3)
- SMN Protein Contributes to Skeletal Muscle Cell Maturation Via Caspase-3 and Akt Activation (2020) (3)
- Protective effects of bilberry and lingonberry (2014) (3)
- Pharmacological Effects of Aquilaria spp. Leaves and Their Chemical Constituents (2016) (3)
- Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents. (2021) (3)
- Tissue Plasminogen Activator Prevents Restoration of Tight Junction Proteins Through Upregulation of Angiopoietin-2 (2012) (3)
- Piezo1 activation induces fibronectin reduction and PGF2α secretion via arachidonic acid cascade. (2021) (3)
- Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography (2005) (3)
- A Three-Dimensional Collagen Gel Contraction Monitoring System that Uses A Porcine Trabecular Meshwork for Screening of Anti-IntraocularPressure Agents (2012) (2)
- The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase injury (2017) (2)
- Identification of VGF nerve growth factor inducible-producing cells in human spinal cords and expression change in patients with amyotrophic lateral sclerosis (2020) (2)
- Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice (2021) (2)
- Carotenoids of land-locked and sea-run types of masu salmon Oncorhynchus masou ishikawae inhabiting in the Nagara River, Japan, from the perspective of chemical ecological study (2020) (2)
- Water extract of Brazilian green propolis attenuates high glucose-induced vascular morphological abnormality in zebrafish (2018) (2)
- [Involvement of endoplasmic reticulum stress in pathogenesis after cerebral ischemia]. (2010) (2)
- Exposure to Blue LED Light at Subjective Daytime Does not Affect Brain Function in Pigmented Mice (2017) (2)
- Inhibitory effects of ASP6537, a selective cyclooxygenase-1 inhibitor, on thrombosis and neointima formation in rats. (2017) (2)
- Characterization of an L-Carnitine Transport System in Murine Photoreceptor Cell Line. (2017) (2)
- Creation of retinal vein occlusion model in cynomolgusmonkeys and determination of its pathological features. (2020) (2)
- [Effects of ocular hypotensive agents on the circadian rhythm in intraocular pressure in rabbits as measured by telemetry]. (2003) (2)
- Involvement of Cerebral Blood Flow on Neurological and Behavioral Functions after Subarachnoid Hemorrhage in Mice. (2021) (2)
- Comparison of Efficacy and Safety Evaluation of Latanoprost Formulations with and without Benzalkonium Chloride (2013) (2)
- Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats (2019) (2)
- The effects of valproate and olanzapine on the abnormal behavior of diacylglycerol kinase β knockout mice. (2015) (2)
- Central Changes in Glaucoma: Neuroscientific Study Using Animal Models (2011) (1)
- The Involvement of Anthocyanin‐Rich Foods in Retinal Damage (2016) (1)
- Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma (2013) (1)
- Antiangiogenic Effects of Chinese Medicines (Hachimijiogan and Kogikujiogan) on Vascular Endothelial Growth Factor-A-Induced Tube Formation in Human Umbilical Vein Endothelial Cells Co-Cultured with Fibroblasts (2008) (1)
- Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model (2022) (1)
- Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database (2016) (1)
- Guanabenz and Clonidine, α2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization. (2021) (1)
- The effect of GPNMB on muscular atrophy caused by ALS (2015) (1)
- The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells (2020) (1)
- [Experimental techniques for animal models of retinal vein occlusion in mice]. (2017) (1)
- Potent Intraocular Pressure Reducing Effects of AFP-168, a New Prostanoid FP Receptor Agonist (2003) (1)
- Anti-diabetic effects of astaxanthin-rich extract derived from Paracoccus carotinifaciens on pancreatic β cells (2022) (1)
- Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK (2022) (1)
- Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure. (2021) (1)
- Laxative effect of agarwood [Aquilaria sinensis] leaves and its mechanism (2008) (1)
- Central Nervous System Migration of Astaxanthin and Adonixanthin Following Their Oral Administration in Cynomolgus Monkeys. (2020) (1)
- Phosphoethanolamine Elevation in Plasma of Spinal Muscular Atrophy Type 1 Patients. (2020) (1)
- Retina Toll-Like Receptor 4 Mediates Retinal Ischemia / Reperfusion Injury Through Nuclear Factor-j B and Spleen Tyrosine Kinase Activation (2013) (1)
- [Establishment of retinal disease models using non-human primates and its strategy for drug discovery]. (2018) (1)
- The Novel cPLA2 Inhibitor AK106-001616 Has a Protective Effect on SOD1 G93A -Induced Cell Death in NSC34 Murine Motor Neuron-Like Cell (2016) (1)
- Involvement of Endoplasmic Reticulum Stress in Retinal Cell Death (2007) (1)
- Retinal Degeneration and Microglial Dynamics in Mature Progranulin-Deficient Mice (2021) (1)
- Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage (2019) (1)
- Effects of Bunazosin Hydrochloride, an 1-adrenoceptor Antagonist, on the Retinal Artery Diameter in Rabbits (2003) (1)
- Retinal damage alters gene expression profile in lacrimal glands of mice. (2022) (1)
- Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia. (2022) (1)
- Distribution of Carotenoids and Protective Effects of Zeaxanthin on Retina of Ayu Sweetfish (Plecoglossus altivelis). (2020) (1)
- Protective effects of Huperzia serrata and its components against oxidative damage and cognitive dysfunction (2020) (1)
- [Prospects and Challenges of Anti-VEGF Drug Treatment for Pathological Angiogenesis of the Retina]. (2021) (1)
- The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment. (2021) (1)
- The protective effects of levetiracetam on spinal muscular atrophy models (2018) (0)
- VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models (2019) (0)
- Author Correction: Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF (2018) (0)
- Tauroursodeoxycholic Acid Promotes Neuronal Survival and Proliferation of Tissue Resident Stem and Progenitor Cells in Retina of Adult Zebrafish (2020) (0)
- Analysis of the Cell Death and APP Induction Mechanism by Aβ Oligomer in Retinal Ganglion Cell (2009) (0)
- [Current therapeutic approaches and involvement of amyloid-beta in retinal diseases]. (2009) (0)
- Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models (2020) (0)
- The role of a novel hyaluronan depolymerization factor, HYBID, on glioma (2020) (0)
- Involvement of Endoplasmic Reticulum Stress on Neuronal Degeneration in the Lateral Geniculate Nucleus in the Monkey Glaucoma Model (2010) (0)
- Hemoglobin-related molecules injure blood-brain barrier via iron accumulation (2018) (0)
- P.3.b.004 Abnormal behaviours of conditional heparin-binding epidermal growth factor-like growth factor knockout mice (2009) (0)
- The Effect of an Inducer of Bip, an ER-Resident Molecular Chaperone, on Light-Induced Retinal Damages (2010) (0)
- Edaravone, a free radical scavenger, inhibits laser-induced choroidal neovascularization in mice by reducing the oxidative stress. (2014) (0)
- A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death (2018) (0)
- The pathophysiological roles of vascular endothelial growth factor (VEGF) on retinal edema and nonperfusion areas in retinal vein occlusion murine model (2018) (0)
- Effects of Combined Treatment with Bunazosin Hydrochloride and Latanoprost on Intraocular Pressure in Monkeys (2003) (0)
- P2-395: A novel therapeutic strategy for Alzheimer's disease by a molecular chaperone inducer (2008) (0)
- Contents Vol. 86, 2010 (2010) (0)
- 筋委縮性側索硬化症(ALS)の治療と早期診断(最前線) (2013) (0)
- The Effect of SUN N8075 on Endoplasmic Reticulum Stress-Induced Cell Death in RGC-5 Cells (2010) (0)
- Improving agents optic papillary circulation. (1999) (0)
- Acknowledgement to Referees for Pharmacology 2010 (2010) (0)
- Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF (2017) (0)
- Evaluation of the pathological symptoms in retinal vascular disease with neovascular glaucoma (2021) (0)
- Anti-VEGFR2 antibody-modified micelle for triggered drug delivery and effective therapy of choroidal neovascularization. (2019) (0)
- Progranulin and Central Nervous System Disorders (2019) (0)
- Identification of the Stress Which Causes Optineurin Aggregation (2019) (0)
- The role of progranulin on cardiac remodeling after myocardial infarction (2022) (0)
- Effects of ticagrelor in a mouse model of ischemic stroke (2017) (0)
- Establishment and Effects of Ginger and Kikyoto of a Haloperidol-Induced Dysphagia Model in Guinea Pigs (2016) (0)
- Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems (2019) (0)
- The involvement of heparin-binding epidermal growth factor like growth factor (HB-EGF) on choroidal neovascularization (2014) (0)
- Potential of cilostazol for treatment of stroke from basic research (2016) (0)
- Survival Motor Neuron Protein Modulates Lysosomal Function Through the Expression of Transcription Factor EB in Motoneurons (2020) (0)
- ALK5 inhibitor acts on trabecular meshwork cell and reduces intraocular pressure. (2023) (0)
- Continuous measurement by telemetry system of circadian IOP variations during 12 weeks treatment with beta–blockers in rabbits (2004) (0)
- Brazilian green propolis promotes the cytoprotective expression of heme oxygenase-1 against oxidative stress injury in murine myoblast cells (2020) (0)
- New Therapeutic Approaches Against Ocular Diseases (2019) (0)
- Important role of diacylglycerol kinase β in spine formation and memory (2009) (0)
- Retinal Cell Biology Granulin 1 Promotes Retinal Regeneration in Zebrafish (2018) (0)
- The effect of anti-adiponectin antibody on experimental macular edema (2019) (0)
- The potential therapeutic targets for the macular edema in murine retinal vein occlusion model (2019) (0)
- Ropinirole Prevents Light-Induced Retinal Photoreceptor Damage in Mice (2021) (0)
- PT674. VGF overexpression mice exhibited several behavioral abnormalities with disruption of brain organization: implication in mental disorders. (2016) (0)
- Abstract WP264: The Growth Factor Progranulin Suppresses Inflammatory Reactions and Attenuates Neuronal Injury Induced by Cerebral Ischemia-Reperfusion in Mice. (2013) (0)
- Establishment of the exudative age related macular degeneration model using the common marmoset (2014) (0)
- [Current Status of the Pharmacological Treatment of Glaucoma and Its Prospects]. (2021) (0)
- Intake of Lactobacillus Pentosus TJ515 Prevents the Formation of Retinal Edema in Retinal Vein Occlusion Model Mice (2023) (0)
- Progranulin deficiency on macrophages exacerbates choroidal neovascularization via inflammation (2020) (0)
- Anti-tumor effects of astaxanthin and adonixanthin on glioblastoma cells (2019) (0)
- Nrf 2 ↑ Anti-oxidant gene transcription ↑ Oxidative stress Cell death Blue light (2016) (0)
- A novel calpain inhibitor, SNJ-1945, reduces murine retinal cell death in vitro and in vivo (2009) (0)
- In models of intracerebral hemorrhage, rivaroxaban is superior to warfarin to limit blood brain barrier disruption and hematoma expansion. (2016) (0)
- Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice. (2021) (0)
- Effects of Kallidinogenase on Retinal Neovasocularization (2009) (0)
- Inhibitory Effect of Alpha-Crystallins on VEGF-Induced Proliferation of Retinal Microvascular Endothelial Cells (2018) (0)
- Neuroprotective Effects of Agmatine on Ischemia-Reperfusion-Induced Retinal Ganglion Cell Damage by Transient Middle Cerebral Artery Occlusion (2010) (0)
- VGF nerve growth factor inducible has the potential to protect pancreatic β-cells. (2023) (0)
- Effect of Piezo 1, a mechanoreceptor, on intraocular pressure and trabecular meshwork (2020) (0)
- The involvement of progranulin for α-synuclein reduction through autolysosome formation (2019) (0)
- VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush (2018) (0)
- Development of diabetic retinopathy model using retinal organoids (2022) (0)
- TOPOGRAPHIC CHANGES IN THE OPTIC NERVE HEAD OVER TIME IN CHRONIC EXPERIMENTAL GLAUCOMA EVALUATED BY SCANNING LASER TOMOGRAPHY (2003) (0)
- [Aiming to overcome ALS - the biomarkers for ALS]. (2014) (0)
- [Retinal neovascularization and its therapeutic agents]. (2010) (0)
- Adiponectin is a pathological factor for intraocular angiogenesis (2018) (0)
- Protective effect of N-acetylcysteine against the cytoskeletal injury induced by cigarette tobacco extract and heated tobacco products in C2C12 myoblasts (2022) (0)
- PT680. Distribution and brain function of Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization (HYBID, KIAA1199) in mouse central nerve system. (2016) (0)
- Progress in axonal and neuronal degenerations of visual pathways in experimental glaucoma monkeys: Imaging studies with PET and DTI (2011) (0)
- Progranulin deficiency causes the retinal ganglion cell loss during development (2017) (0)
- The involvement of apolipoprotein E on intraocular angiogenesis (2013) (0)
- P.2.f.001 Mania-like behavioural abnormalities of diacylglycerol kinase β knockout mice (2009) (0)
- P.1.d.008 Diacylglycerol kinase β knockout mice show an abnormal response on psychostimulant-induced behavioural change (2010) (0)
- Progranulin knockout mice show the outer retinal abnormalities similar to advanced AMD (2019) (0)
- The role of Cannabinoid receptors on light-induced photoreceptor degeneration (2013) (0)
- [Evaluation system to search for inhibitory effect of retinal neovascularization in vitro and in vivo]. (2007) (0)
- Effects of propofol with EDTA on cell damage induced by oxygen and glucose deprivation (OGD) in PC12 cell cultures and middle cerebral artery (MCA) occlusion in mice: A-597 (2006) (0)
- Glutamatergic dysfunction is associated with phenotypes of VGF-overexpressing mice (2022) (0)
- Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model. (2023) (0)
- A novel Nrf2 activator RS9 protects ARPE-19 cells from oxidative stress induced by NaIO 3 via autophagic pathway (2018) (0)
- P4-346 Application of molecular chaperone inducer for Alzheimer disease (2006) (0)
- Corrigendum to ‘Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice’ [Journal of Pharmacological Sciences 148 (2022) 65-72] (2022) (0)
- TheChanges inBloodFlowSeen in the Eye after FootAcupuncture Treatment in Mice (2020) (0)
- The involvement of G protein-coupled receptor 35 on pathology of non-exudative age-related macular degeneration (2019) (0)
- The inhibition of Notch signaling ameliorates the motor functional deficits and astrocytic abnormality of in vitro and in vivo spinal muscular atrophy models (2018) (0)
- Exploratory studies on novel therapeutic targets for intraocular vascular lesions (2021) (0)
- Huperzia serrata and the Constitute of Huperzine A Attenuate MK-801-Induced Cognitive Dysfunction in Mice via PKC-Erk Pathway (2021) (0)
- The oligodendrocyte derived from familial glaucoma patients-iPSCs decreases neuroprotective action for retinal ganglion cells (2018) (0)
- [Experimental techniques for animal models of retinal diseases in mice]. (2007) (0)
- The Effects of Rufinamide on in Vitro Spinal Muscular Atrophy Model (2019) (0)
- Tracking of disease progression over time with optic nerve diffusion tensor imaging and retinal nerve fiber layer thickness in macaques with experimental glaucoma (2019) (0)
- Author Correction: Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF (2018) (0)
- Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells. (2022) (0)
- Involvement of Amyloid-ß in Retinal Function (2007) (0)
- The Roles for DNA Damage Response in Retinal Ganglion Cell Death (2012) (0)
- Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation (2021) (0)
- The role of ANKFY1 in endothelial cells for retinal angiogenesis (2021) (0)
- Importance of CBF measurement to exclude concomitant cerebral infarction in the murine endovascular perforation SAH model. (2020) (0)
- The protective effect of a novel radical scavenger, NSP-116 on cerebral ischemia injury (2019) (0)
- The effect of VGF nerve growth factor inducible on retinal ganglion cell injury after optic nerve crush in mice (2018) (0)
- Impaired Cerebellar Development in Mice Overexpressing VGF (2018) (0)
- TRPV4 channels promote vascular permeability in retinal vascular disease. (2023) (0)
- Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis (2019) (0)
- Agents de protection du nerf optique contenant un bloqueur de recepteur alpha 1 en tant qu'ingredient actif (2002) (0)
- [Look Back on the Eye with Basic Research, Clinical Science and Drug Repositioning]. (2021) (0)
- The involvement of heparin-binding epidermal growth factor like growth factor on light-induced retinal degeneration (2013) (0)
- GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response (2017) (0)
- Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model (2021) (0)
- Fluvoxamine attenuates tau phosphorylation through an upregulation of sigma-1 receptors (Sig-1Rs) (2013) (0)
- Molecular brain imaging in the glaucoma model of monkeys using PET and MRI (2011) (0)
- Optical papillarzirkulation improving agent (1999) (0)
- RS9, an Nrf2 activator, accelerates LC3-assosciated phagocytosis via dual activation of AMPK/mTOR and Nrf2/SQSTM1 signaling in retinal pigment epithelium (2019) (0)
- Effects of Ocular Hypotensive Agents on Circadian Rhythms of Intraocular Pressure in Rabbits as Measured by Telemetry System (2004) (0)
- The Protective Effect of Blue Light Cutting Particles Mixed Optical Material against Blue LED Light-Induced Photoreceptor and Cornea Cell Death (2019) (0)
- The Protective Effects of Levetiracetam on a Human iPSCs-Derived Spinal Muscular Atrophy Model (2019) (0)
- Subject Index Vol. 86, 2010 (2010) (0)
- Oral administration of NSP-116, a free radical scavenger, suppresses the symptoms of retinal vein occlusion in the murine model. (2021) (0)
- BCL6B (B-Cell CLL/Lymphoma 6 Member B Protein) Contributes to Ocular Vascular Diseases via Notch Signal Silencing. (2023) (0)
- The photoreceptor damage induced by blue light emitting diode light and the involvement of oxidative stress. (2014) (0)
- Protective Effects of Indonesian Propolis Against Light-Induced Retinal Damage (2017) (0)
- Development of a macaque model of dry, nonexudative form age-related macular degeneration with geographic atropy (2019) (0)
- Low concentrations of levofloxacin can decrease UV-induced cellular damage (2017) (0)
- Protective Effects of Cilostazol Against Transient Focal Cerebral Ischemia and Hemorrhagic Transformation (2011) (0)
- The pathological association between the anterior eye segment and the retina in a murine model of neovascular glaucoma (2022) (0)
- Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium (2022) (0)
- Differentiation of Induced Pluripotent Stem Cells ( iPSCs ) into Retinal Ganglion Cells ( RGCs ) in Culture (2019) (0)
- Glaucoma remedy comprising a Rho kinase inhibitor and prostaglandins (2003) (0)
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What Schools Are Affiliated With Hideaki Hara?
Hideaki Hara is affiliated with the following schools:
