Hideaki Nagase

Q: What Schools Are Affiliated With Hideaki Nagase

Hideaki Nagase is affiliated with the following schools: Imperial College London, University of Oxford, University of Tokyo, Tokyo University of Agriculture and Technology, Institute of Science Tokyo, Miami University, University of Kansas School of Medicine, Columbia University, Technical University of Munich, Kyoto University, Florida Atlantic University, University of Nebraska Medical Center

Hideaki Nagase's AcademicInfluence.com Rankings

Hideaki Nagase

Computer Science

#3330

World Rank

#3493

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Computational Linguistics

#149

World Rank

#153

Historical Rank

Machine Learning

#369

World Rank

#374

Historical Rank

Artificial Intelligence

#561

World Rank

#572

Historical Rank

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Computer Science

Hideaki Nagase's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

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Hideaki Nagase's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry (2003) (4365)
Structure and function of matrix metalloproteinases and TIMPs. (2006) (2935)
Tissue inhibitors of metalloproteinases: evolution, structure and function. (2000) (1913)
Activation mechanisms of matrix metalloproteinases. (1997) (1228)
The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. (2010) (1114)
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. (1999) (691)
Progress in matrix metalloproteinase research. (2008) (662)
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1 (1997) (606)
Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. (1992) (602)
Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion* (1999) (599)
TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)* (2001) (520)
Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family* (1999) (493)
Proteases involved in cartilage matrix degradation in osteoarthritis. (2012) (487)
Degradation of chromosomal DNA during apoptosis (2003) (448)
Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition (2002) (435)
Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). (1990) (434)
Collagenase unwinds triple‐helical collagen prior to peptide bond hydrolysis (2004) (433)
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization. (1986) (428)
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. (1990) (419)
Matrix metalloproteinases and TIMPs (2000) (419)
Aggrecanases and cartilage matrix degradation (2003) (411)
Matrix metalloproteinases in cancer. (2002) (409)
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate. (1990) (383)
Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. (1998) (372)
Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. (1994) (351)
Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation. (1989) (349)
Degradation of Interleukin 1β by Matrix Metalloproteinases* (1996) (336)
Structural properties of matrix metalloproteinases (1999) (320)
Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. (1992) (319)
Matrix Metalloproteinases* (1999) (318)
Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides. (1996) (295)
Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair? (2008) (287)
Proteolytic Activities of Human ADAMTS-5 (2007) (258)
Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. (1998) (254)
Altered Proteolytic Activities of ADAMTS-4 Expressed by C-terminal Processing* (2004) (235)
The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. (1998) (223)
Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. (1994) (222)
Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall. (1994) (221)
Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). (1994) (214)
Insights into MMP‐TIMP Interactions (1999) (203)
Cell surface activation of progelatinase A (proMMP-2) and cell migration (1998) (202)
Steps Involved in Activation of the Pro-matrix Metalloproteinase 9 (Progelatinase B)-Tissue Inhibitor of Metalloproteinases-1 Complex by 4-Aminophenylmercuric Acetate and Proteinases (*) (1995) (200)
Matrix metalloproteinase production by cultured human endometrial stromal cells: identification of interstitial collagenase, gelatinase-A, gelatinase-B, and stromelysin-1 and their differential regulation by interleukin-1 alpha and tumor necrosis factor-alpha. (1994) (200)
YAP is essential for tissue tension to ensure vertebrate 3D body shape (2015) (200)
Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases (1988) (200)
Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis. (1989) (199)
Preferential Inactivation of Tissue Inhibitor of Metalloproteinases-1 That Is Bound to the Precursor of Matrix Metalloproteinase 9 (Progelatinase B) by Human Neutrophil Elastase (*) (1995) (195)
Purification and characterization of matrix metalloproteinase 9 from U937 monocytic leukaemia and HT1080 fibrosarcoma cells. (1992) (194)
The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin. (1988) (188)
Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors (2003) (185)
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1 (2012) (184)
Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma. (1999) (180)
The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression* (1997) (174)
Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases (1999) (170)
Urokinase Plasminogen Activator and Gelatinases Are Associated with Membrane Vesicles Shed by Human HT1080 Fibrosarcoma Cells* (1997) (165)
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period. (1997) (163)
Selective localization of matrix metalloproteinase 9, beta1 integrins, and human lymphocyte antigen class I molecules on membrane vesicles shed by 8701-BC breast carcinoma cells. (1998) (158)
Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility. (1997) (158)
Plasma Membrane-bound Tissue Inhibitor of Metalloproteinases (TIMP)-2 Specifically Inhibits Matrix Metalloproteinase 2 (Gelatinase A) Activated on the Cell Surface* (1998) (158)
Substrate specificities and activation mechanisms of matrix metalloproteinases. (1991) (157)
Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation. (1995) (156)
Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes (2014) (153)
Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. (2007) (152)
Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice (2015) (152)
Nomenclature and glossary of the matrix metalloproteinases. (1992) (148)
Differential Inhibition of Membrane Type 3 (MT3)-Matrix Metalloproteinase (MMP) and MT1-MMP by Tissue Inhibitor of Metalloproteinase (TIMP)-2 and TIMP-3 Regulates Pro-MMP-2 Activation* (2004) (147)
Hormonal regulation of collagenolysis in uterine cervical fibroblasts. Modulation of synthesis of procollagenase, prostromelysin and tissue inhibitor of metalloproteinases (TIMP) by progesterone and oestradiol-17 beta. (1991) (144)
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases : Structure (2003) (143)
Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases. (1995) (142)
The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate. (1988) (137)
A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process. (2000) (133)
Individual Timp Deficiencies Differentially Impact Pro-MMP-2 Activation* (2006) (125)
Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells. (2003) (125)
Importance of matrix metalloproteinases in human trophoblast invasion. (1995) (123)
Immunolocalization of the matrix metalloproteinases gelatinase B and stromelysin 1 in human endometrium throughout the menstrual cycle. (1996) (121)
Identification of the 183RWTNNFREY191Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity* (2000) (119)
Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). (1991) (119)
Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis. (2009) (118)
Hydrolysis of Triple-helical Collagen Peptide Models by Matrix Metalloproteinases* (2000) (117)
Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases. (1994) (117)
Localizing matrix metalloproteinase activities in the pericellular environment (2011) (116)
Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases (2008) (114)
Continuously recording fluorescent assays optimized for five human matrix metalloproteinases. (1991) (113)
Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase. (1988) (111)
Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium. (1983) (111)
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1 (2016) (108)
Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. (2005) (106)
A Novel Host/Tumor Cell Interaction Activates Matrix Metalloproteinase 1 and Mediates Invasion through Type I Collagen* (1999) (106)
Co-culture of human breast adenocarcinoma MCF-7 cells and human dermal fibroblasts enhances the production of matrix metalloproteinases 1, 2 and 3 in fibroblasts. (1995) (104)
Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. (1992) (104)
Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond. (1996) (103)
Low Density Lipoprotein Receptor-related Protein Mediates Endocytic Clearance of Pro-MMP-2·TIMP-2 Complex through a Thrombospondin-independent Mechanism* (2004) (103)
Production of tissue collagenase (matrix metalloproteinase 1) by human aortic smooth muscle cells in response to platelet-derived growth factor. (1991) (103)
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. (2000) (102)
Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate. (1995) (101)
Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP. (2006) (101)
Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis (2010) (101)
Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP‐3 (2002) (100)
Selective Hydrolysis of Triple-helical Substrates by Matrix Metalloproteinase-2 and -9* (2003) (100)
Crystal Structure of an Active Form of Human MMP-1 (2006) (100)
Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases* (2010) (100)
Activation of ProMMP‐9 by a Plasmin/MMP‐3 Cascade in a Tumor Cell Model: Regulation by Tissue Inhibitors of Metalloproteinases (1999) (100)
Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network. (2002) (99)
TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2. (2006) (99)
Characterization of an immunosuppressive factor derived from colon cancer cells. (1987) (97)
Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II. (1995) (97)
Matrix metalloproteinases. A mini-review. (1994) (96)
The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity* (2006) (94)
Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells (1989) (93)
Folding and characterization of the amino‐terminal domain of human tissue inhibitor of metalloproteinases‐1 (TIMP‐1) expressed at high yield in E. coli (1996) (91)
Mutational Study of the Amino-terminal Domain of Human Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) Locates an Inhibitory Region for Matrix Metalloproteinases* (1997) (91)
X-ray Structure of Human proMMP-1 (2005) (90)
Functional Differences of the Catalytic and Non-catalytic Domains in Human ADAMTS-4 and ADAMTS-5 in Aggrecanolytic Activity* (2008) (89)
Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors. (2003) (88)
TIMP‐3 inhibits aggrecanase‐mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors (2003) (88)
LRP‐1‐mediated endocytosis regulates extracellular activity of ADAMTS‐5 in articular cartilage (2013) (88)
Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion. (2010) (87)
Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Inhibition of procollagenase secretion by monensin and evidence for glycosylation of procollagenase. (1983) (85)
Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates. (2001) (83)
Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3. (1989) (82)
Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints. (1987) (81)
Salmonella virchow infection in an infant transmitted by household dogs. (2000) (81)
Cell cholesterol modulates metalloproteinase‐dependent shedding of low‐density lipoprotein receptor‐related protein‐1 (LRP‐1) and clearance function (2011) (77)
Structural Analysis of the α2 Integrin I Domain/Procollagenase-1 (Matrix Metalloproteinase-1) Interaction* (2001) (77)
Residue 2 of TIMP-1 Is a Major Determinant of Affinity and Specificity for Matrix Metalloproteinases but Effects of Substitutions Do Not Correlate with Those of the Corresponding P1′ Residue of Substrate* (1999) (75)
Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites. (1989) (75)
E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A). (2002) (75)
Immunohistochemical demonstration of collagenase and tissue inhibitor of metalloproteinases (TIMP) in synovial lining cells of rheumatoid synovium (1990) (74)
The expression of gelatinase A (MMP-2) is required for normal development of zebrafish embryos (2003) (74)
[27] Human stromelysins 1 and 2 (1995) (74)
Ovostatin: a novel proteinase inhibitor from chicken egg white. I. Purification, physicochemical properties, and tissue distribution of ovostatin. (1983) (74)
Human plasma kallikrein. A rapid purification method with high yield. (1981) (73)
Matrix Metalloproteinase 1 Interacts with Neuronal Integrins and Stimulates Dephosphorylation of Akt* (2004) (72)
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein. (2011) (71)
Interleukin‐1 Acts via the JNK‐2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes (2015) (70)
A precursor form of latent collagenase produced in a cell-free system with mRNA from rabbit synovial cells. (1981) (70)
Hormonal regulation of matrix metalloproteinase 9/gelatinase B gene expression in rabbit uterine cervical fibroblasts. (1997) (69)
Stromelysins 1 and 2 (1998) (69)
Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes. (2004) (68)
Catalytic properties of ADAM12 and its domain deletion mutants. (2008) (68)
Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability. (2004) (68)
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) is induced in rabbit articular chondrocytes by cotreatment with interleukin 1 beta and a protein kinase C activator. (1992) (67)
Matrix metalloproteinases and their inhibitors in human vitreous. (1998) (66)
Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP. (1996) (66)
An improved assay for proteases and polysaccharidases employing a cartilage proteoglycan substrate entrapped in polyacrylamide particles. (1980) (64)
Engineering of Selective TIMPs (1999) (64)
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications (2010) (63)
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. (2001) (63)
Ovostatin: a novel proteinase inhibitor from chicken egg white. II. Mechanism of inhibition studied with collagenase and thermolysin. (1983) (62)
Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin). (1988) (62)
The Second Dimer Interface of MT1-MMP, the Transmembrane Domain, Is Essential for ProMMP-2 Activation on the Cell Surface* (2008) (62)
Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis (2015) (61)
Defining Requirements for Collagenase Cleavage in Collagen Type III Using a Bacterial Collagen System* (2012) (61)
Palmitoylation at Cys574 is essential for MT1‐MMP to promote cell migration (2005) (61)
Reactive Site Mutations in Tissue Inhibitor of Metalloproteinase-3 Disrupt Inhibition of Matrix Metalloproteinases but Not Tumor Necrosis Factor-α-converting Enzyme* (2005) (60)
Human breast carcinoma cells cultured in the presence of serum shed membrane vesicles rich in gelatinolytic activities. (1994) (60)
Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1 (2012) (60)
Matrix metalloproteinases and their tissue inhibitors at the ovine trophoblast-uterine interface. (2019) (59)
A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function. (1995) (59)
Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid. (1982) (59)
Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3 (2014) (59)
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity (2012) (59)
Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1). (1993) (58)
Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules. (1996) (57)
Protein Engineering of the Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) Inhibitory Domain (2003) (55)
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. (2009) (55)
The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain (2010) (54)
Zymography of Metalloproteinases (2003) (53)
MMPs Are IGFBP‐Degrading Proteinases: Implications for Cell Proliferation and Tissue Growth (1999) (53)
Increased level of translatable collagenase messenger ribonucleic acid in rabbit synovial fibroblasts treated with phorbol myristate acetate or crystals of monosodium urate monohydrate. (1982) (53)
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. (2009) (52)
Production of matrix metalloproteinases 2 and 3 (stromelysin) by stromal cells of giant cell tumor of bone. (1992) (51)
Altered kidney matrix gene expression in early stages of experimental diabetes. (1997) (51)
Interaction of α2‐Macroglobulin with Matrix Metalloproteinases and Its Use for Identification of Their Active Forms a (1994) (50)
Stepwise activation mechanisms of the precursors of matrix metalloproteinases 1 (tissue collagenase) and 3 (stromelysin). (1991) (50)
N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1 (2004) (49)
Substrate Specificity of MMPs (2001) (49)
Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics (2002) (49)
Alpha-fetoprotein (AFP) levels in normal children. (1997) (49)
Rabbit procollagenase synthesized and secreted by a high-yield mammalian expression vector requires stromelysin (matrix metalloproteinase-3) for maximal activation. (1990) (49)
Characterization of Rat Uterine Matrilysin and Its cDNA (1995) (48)
Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases. (2005) (48)
Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in Escherichia coli: Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) (1998) (48)
Brief Report: JNK‐2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis (2015) (47)
Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) (2014) (46)
Relationship of procollagenase activator, stromelysin and matrix metalloproteinase 3. (1988) (46)
Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1). (1997) (44)
Gelatin-degrading type IV collagenase isolated from human small cell lung cancer. (1989) (44)
Elucidating the Function of Non catalytic Domains of Collagenases and Aggrecanases (2008) (44)
The expression of novel membrane-type matrix metalloproteinase isoforms is required for normal development of zebrafish embryos. (2003) (43)
Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis (2017) (43)
Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma. (2000) (43)
Human recombinant interleukin‐1α‐mediated stimulation of procollagenase production and suppression of biosynthesis of tissue inhibitor of metalloproteinases in rabbit uterine cervical fibroblasts (1988) (43)
Calmodulin differentially modulates the interleukin 1-induced biosynthesis of tissue inhibitor of metalloproteinases and matrix metalloproteinases in human uterine cervical fibroblasts. (1991) (43)
Shear stress‐induced shedding of soluble intercellular adhesion molecule‐1 from saphenous vein endothelium (2004) (42)
Endoproteinase‐protein inhibitor interactions (1999) (42)
Involvement of tissue inhibitors of metalloproteinases (TIMPS) during matrix metalloproteinase activation. (1996) (42)
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. (2011) (42)
Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15 (2015) (42)
Hydroxyapatite Induces Autolytic Degradation and Inactivation of Matrix Metalloproteinase‐1 and ‐3 (1998) (42)
Cyclic adenosine 3',5'-monophosphate suppresses interleukin 1-induced synthesis of matrix metalloproteinases but not of tissue inhibitor of metalloproteinases in human uterine cervical fibroblasts. (1991) (41)
Tumor necrosis factor α (TNFα) induces pro‐matrix metalloproteinase 9 production in human uterine cervical fibroblasts but interleukin 1 α antagonizes the inductive effect of TNFα (1996) (40)
The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms. (2001) (40)
Effect of matrix glycation on expression of type IV collagen, MMP-2, MMP-9 and TIMP-1 by human mesangial cells. (1996) (39)
Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases. (2000) (39)
Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity* (2010) (38)
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation. (2013) (38)
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2). (2010) (38)
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2) (2015) (37)
Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth (2016) (37)
Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts. (1988) (36)
The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos (2003) (36)
Localization of collagenase at the basal plasma membrane of a human pancreatic carcinoma cell line. (1990) (35)
Involvement of protein kinase C in the interleukin 1 alpha-induced gene expression of matrix metalloproteinases and tissue inhibitor-1 of metalloproteinases (TIMP-1) in human uterine cervical fibroblasts. (1993) (35)
TIMP-1 contact sites and perturbations of stromelysin 1 mapped by NMR and a paramagnetic surface probe. (1998) (35)
Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1. (2007) (34)
Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids. (2003) (34)
Differential expression of gelatinase B (MMP-9) and stromelysin-1 (MMP-3) by rheumatoid synovial cells in vitro and in vivo (2004) (34)
DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis. (2015) (34)
Selective immunosuppressive action of a factor produced by colon cancer cells. (1990) (34)
Shed Membrane Vesicles and Selective Localization of Gelatinases and MMP‐9/TIMP‐1 Complexes (1999) (33)
In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen‐Induced Arthritis (2014) (33)
Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage. (2011) (33)
Production of matrix metalloproteinase 1 (interstitial collagenase) and matrix metalloproteinase 2 (gelatinase A: 72 kDa gelatinase) by ovine endometrial cells in vitro: different regulation and preferential expression by stromal fibroblasts. (1993) (33)
Distinct biological events generated by ECM proteolysis by two homologous collagenases (2016) (33)
Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption (2017) (32)
Matrix metalloproteinase (stromelysin-1) increases the albumin permeability of isolated rat glomeruli. (1996) (32)
Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis* (2015) (32)
Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation (2003) (32)
Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer. (2011) (32)
Substrate Conformation Modulates Aggrecanase (ADAMTS-4) Affinity and Sequence Specificity (2007) (32)
Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats. (2013) (31)
Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex (2012) (31)
Tailoring TIMPs for Selective Metalloproteinase Inhibition (2008) (30)
In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis. (2014) (30)
Crystal structure of full‐length human collagenase 3 (MMP‐13) with peptides in the active site defines exosites in the catalytic domain (2013) (30)
Digestion of C1q collagen‐like domain with MMPs‐1, ‐2, ‐3, and ‐9 further defines the sequence involved in the stimulation of neutrophil superoxide production (1999) (30)
X-ray Structure of Human proMMP-1 NEW INSIGHTS INTO PROCOLLAGENASE ACTIVATION AND COLLAGEN BINDING* (2005) (29)
Human stromelysins 1 and 2. (1995) (28)
BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice. (2016) (27)
Inhibition of Liver Metastasis from Orthotopically Implanted Colon Cancer in Nude Mice by Transfection of the TIMP-1 Gene into KM12SM Cells (2001) (27)
Interaction of alpha 2-macroglobulin with matrix metalloproteinases and its use for identification of their active forms. (1994) (27)
Distribution of gelatinase B (MMP-9) and type IV collagen in colorectal carcinoma (1994) (26)
In Vivo Imaging of MMP‐13 Activity Using a Specific Polymer‐FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy (2018) (26)
Collagenase production by immortalized human aortic endothelial cells infected with simian virus 40 (1991) (26)
Progesterone increases the production of tissue inhibitor of metalloproteinases‐2 in rabbit uterine cervical fibroblasts (1994) (26)
Development of a solid-phase assay for analysis of matrix metalloproteinase activity. (2004) (25)
Production of matrix metalloproteinase 3 (stromelysin) by cultured ovine endometrial cells. (1991) (24)
Characterization of the 46-kDa Intermediates of Matrix Metalloproteinase 3 (Stromelysin 1) Obtained by Site-directed Mutation of Phenylalanine 83 (*) (1996) (24)
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization. (2012) (24)
Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography. (2003) (23)
Proteases and the regulation of biological processes (2003) (22)
Urokinase Plasminogen Activator and Gelatinases Are Associated with Membrane Vesicles Shed by Human HT 1080 Fibrosarcoma Cells * (1997) (22)
Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase. (2012) (22)
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity* (2016) (22)
Calmodulin antagonists increase the expression of membrane-type-1 matrix metalloproteinase in human uterine cervical fibroblasts. (1998) (21)
The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer* (2016) (21)
New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold. (2010) (21)
Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue. (2017) (21)
Complete primary structure of human matrix metalloproteinase-3 (1988) (21)
Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma. (2001) (21)
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity (2016) (20)
Calmodulin regulates the interleukin 1-induced procollagenase production in human uterine cervical fibroblasts. (1989) (20)
Amino acid sequence of hen ovomacroglobulin (ovostatin) deduced from cloned cDNA. (1994) (20)
Effects of all-trans-retinoic acid (retinoic acid) and 4-hydroxyphenylretinamide on synovial cells and articular cartilage. (1982) (19)
Evidence for a thiol ester in duck ovostatin (ovomacroglobulin). (1986) (17)
Zinc content and function in human fibroblast collagenase. (1995) (17)
Electron microscopic studies of free and proteinase-bound duck ovostatins (ovomacroglobulins). Model of ovostatin structure and its transformation upon proteolysis. (1988) (17)
Proactivator-dependent activation of procollagenase induced by treatment with EGTA. (1986) (17)
Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage. (2008) (17)
Generation of a mouse line harboring a bi‐transgene expressing luciferase and tamoxifen‐activatable creERT2 recombinase in cartilage (2014) (16)
TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1 (2019) (16)
Triple Helicase Activity and the Structural Basis of Collagenolysis (2011) (16)
Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Timp-1 is Mediated via Effects on Mmp Inhibition: Implications for Reversibility of Liver Fibrosis (2002) (16)
Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3 (2017) (16)
Tumor necrosis factor alpha (TNFalpha) induces pro-matrix metalloproteinase 9 production in human uterine cervical fibroblasts but interleukin 1alpha antagonizes the inductive effect of TNFalpha. (1996) (15)
Efficacy of the MMP inhibitor MMI270 against lung metastasis following removal of orthotopically transplanted human colon cancer in rat (2006) (15)
Analysis of TIMP expression and activity. (2007) (15)
Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human skin fibroblasts. (1991) (14)
LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages (2019) (14)
Translational augmentation of pro‐matrix metalloproteinase 3 (prostromelysin 1) and tissue inhibitor of metalloproteinases (TIMP)‐1 mRNAs induced by epidermal growth factor in human uterine cervical fibroblasts (1996) (13)
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. (2008) (13)
Covalent modification of matrix metalloproteinases by a photoaffinity probe: influence of nucleophilicity and flexibility of the residue in position 241. (2009) (13)
Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity (2013) (13)
Evidence for Restricted Reactivity of ADAMDEC1 with Protein Substrates and Endogenous Inhibitors* (2015) (13)
ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells (2019) (12)
Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group. (2013) (12)
Metalloproteinases in health and disease: challenges and the future prospects (2011) (12)
Proteolytic activities of human ADAMTS-5. comparative studies with human ADAMTS-4 [Erratum] (2007) (12)
Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage. (2018) (12)
Application of hyperspectral fluorescence lifetime imaging to tissue autofluorescence: arthritis (2005) (10)
Characterization of metalloproteinases in rat gastric tissues with acetic acid-induced ulcers. (1989) (10)
Purification and characterization of matrix metalioproteinase 9 from U 937 monocytic leukaemia and HT 1080 fibrosarcoma cells (2005) (10)
Matrix Metalloproteinase 3/Stromelysin 1 (2013) (10)
Metalloproteases (2001) (10)
Degradation of Interleukin 1 (cid:98) by Matrix Metalloproteinases* (1996) (9)
UNIT 21.4 Metalloproteases (2001) (9)
Non-Peptidic Cysteine Derivatives as Inhibitors of Matrix Metalloproteinases (1997) (9)
Insulin-like growth factor binding protein (IGFBP) substrate zymography. A new tool to identify and characterize IGFBP-degrading proteinases. (1997) (8)
The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase. (1990) (8)
Modulation of production of matrix metalloproteinases from ovine endometrial cells by ovine trophoblast interferon. (1994) (8)
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1 (2017) (7)
Expression of epidermal growth-factor (EGF), matrix metalloproteinase-9 (mmp-9) and proliferating cell nuclear antigen (pcna) in esophageal cancer. (1995) (7)
Monitoring Metalloproteinase Activity Using Synthetic Fluorogenic Substrates (2003) (7)
Fluorescence quenching studies of matrix metalloproteinases (MMPs): evidence for structural rearrangement of the proMMP-2/TIMP-2 complex upon mercurial activation. (1996) (7)
Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis. (2018) (7)
Translational augmentation of pro-matrix metalloproteinase 3 (prostromelysin 1) and a tissue inhibitor of metalloproteinases (TIMP)-1 mRNAs by epidermal growth factor and transforming growth factor alpha, but not by interleukin 1 alpha or 12-O-tetradecanoylphorbol 13-acetate in human uterine cervica (1996) (6)
Measurement of Protease Activities Using Fluorogenic Substrates. (2018) (6)
4.5 The ADAMTS family of metalloproteinases (2012) (6)
A personal journey with matrix metalloproteinases (2016) (5)
Simultaneous production of collagenase, matrix metalloproteinase 3 (stromelysin) and tissue inhibitor of metalloproteinases by rheumatoid synovial lining cells. (1992) (5)
Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction. (2006) (5)
Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage (2020) (5)
Aggrecanases in cartilage matrix breakdown (2001) (5)
Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma (2018) (5)
Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases. (2016) (5)
Purification of MMPs and TIMPs. (2010) (4)
Metalloproteinases in Cartilage Matrix Breakdown: The Roles in Rheumatoid Arthritis and Osteoarthritis (2013) (4)
Identification of rabbit uterine cervical procollagenase activator as rabbit matrix metalloproteinase 3 (stromelysin). (1991) (4)
1 Role of the NTR domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity * (2010) (4)
Structural requirements for collagenolytic activity of matrix metalloproteinase 1 (MMP-1) (2002) (4)
Matrix Metalloproteinases: A Role in Implantation? (1994) (4)
Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro. (2016) (4)
Human plasma kallikrein (2005) (3)
Comparative studies of a 92-kDa gelatinolytic metalloproteinase from U937 cells and matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. (1992) (3)
Screening of potential ADAMTS-4 inhibitors utilizing a collagen- model FRET substrate (2008) (3)
Matrix Metalloproteinases: An Overview (2009) (3)
Effects of H2-receptor antagonists on matrix metalloproteinases in rat gastric tissues with acetic acid-induced ulcer. (1991) (3)
Comparative sequence specificities of human fibroblast and neutrophil matrix metalloproteinases. (1992) (3)
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1 (2000) (3)
A multi-substrate metalloproteinase from rheumatoid synovial cells. (1986) (3)
Amino acid sequence of a 32‐residue region around the thiol ester site in duck ovostatin (1987) (3)
Fluorescence lifetime imaging of articular cartilage (2004) (2)
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage. (2022) (2)
Erratum to: Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases (FEBS 22347) (2000) (2)
Interleukin 1 acts via c-jun N-terminal kinase-2 signalling pathway to induce aggrecan degradation by human chondrocytes. (2015) (2)
A two-step sandwich enzyme immunoassay for rabbit proMMP-3 using monoclonal antibodies (1995) (2)
Metalloproteinase-dependent And -independent Processes Contribute To Inhibition Of Breast Cancer Cell Migration, Angiogenesis And Liver Metastasis By A Disintegrin And Metalloproteinase With Thrombospondin Motifs-15. (2014) (2)
The Primary Structure of Ovomacroglobulin (1994) (2)
Crystallization and Preliminary X-Ray Crystallographic Studies of Human Autocrine Motility Factor (2001) (2)
Target-Based Proteolytic Profiling for Characterizing Cancer Progression (2006) (2)
Gene expression profiling and proteomic analysis of cartilage degradation in a mouse model of osteoarthritis (2011) (2)
Ovostatin: a proteinase inhibitor in egg whites that is homologous to alpha 2-macroglobulin. (1985) (2)
Inhibition of LRP1 shedding reverses cartilage degradation in osteoarthritis (2018) (2)
Type I collagen homotrimers may alter tissue remodeling (2008) (2)
Past, Present and Future Insights into the Understanding and Treatment of Osteoarthritis: Molecular and Mechanical Approaches (2009) (2)
ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current Enhancement (2022) (1)
Voltage-Gated Calcium Channel α2δ Subunits in Lipid Rafts: The Importance of Proteolytic Cleavage Into α2 and δ (2012) (1)
Bending rigidity of type I collagen homotrimer fibrils (2009) (1)
A significant role for the JNK pathway in regulating interleukin 1 induced-aggrecan degradation in human articular chondrocytes (2015) (1)
Erratum: Proteolytic activities of human ADAMTS-5. Comparative studies with human ADAMTS-4 (Journal of Biological Chemistry (2007) 282, (18294-18306)) (2007) (1)
Selective hydrolysis of triple-helical peptides by matrix metalloproteinases (2002) (1)
Signaling Metastasis by Induction of Hepatocyte Growth Factor Tissue Inhibitor of Metalloproteinases-1 Promotes Liver (2007) (1)
MT1-MMP is a crucial promotor of synovial invasion in human rheumatoid arthritis (2010) (1)
Tenascin-C fragments induce aggrecanase activity in cartilage (2008) (1)
Insulin-like growth factor binding protein (IGFBP) substrate zymography (1997) (1)
Inflammation in a Murine Model of Asthma Prevents Allergen-Induced Airway Inhibition of Matrix Metalloproteinases (2013) (1)
Kinetic characterization of new selective collagenase-3 (MMP-13) inhibitors as potential therapeutic agents in osteoarthritis (2009) (0)
Human collagenase 3 (MMP-13) with peptide from pro-domain (2013) (0)
Aggrecanases in Cartilage 九 1 : atrixBreakdown (0)
arthritis . correlation with rheumatoid synovioblasts ( B cells ) : ( stromelysin ) in rheumatoid metalloproteinase 3 Immunolocalization of matrix (2004) (0)
ADAMDEC1 mAbs for quantification and activity modulation (2018) (0)
Biochemical Society Symposium: Preface (2003) (0)
CHARACTERIZATION OF AN IMMUNOSUPPRESSIVE COLON CANCER CELLS' FACTOR DERIVED FROM (1987) (0)
INTERLEUKIN-1 ALPHA STIMULATES ADAM17-MEDIATED ECTODOMAIN SHEDDING OF LRP1 AND REDUCES ENDOCYTOSIS OF AGGRECANASES IN ARTICULAR CARTILAGE (2015) (0)
CHONDROCYTE-SPECIFIC TIMP3 OVEREXPRESSION DISRUPTS ENDOCHONDRAL GROWTH AND COMPROMISES BONE STRUCTURE AND INTEGRITY: FUNCTIONAL IMPACT OF THE CHONDROCYTE-TO-OSTEOBLAST LINEAGE (2016) (0)
Design of Selective Collagenase 3 (MMP-13) Inhibitors as Potential Therapeutic Agents in Rheumatoid Arthritis (2008) (0)
Development of imaging agents for the visualisation of cartilage in vivo (2015) (0)
Mechanisms of action of collagenases and TIMPs (2002) (0)
TIMP-1-associated metastasis-promoting gene expression profile in liver-metastasis of colorectal cancer patients can explain tumor aggressiveness (2007) (0)
TARGETING MMPS AND ADAMTSS IN OSTEOARTHRITIS (2007) (0)
Biosynthesis andsecretion ofprocollagenase byrabbit synovial fibroblasts Inhibition ofprocoliagenase secretion bymonensin andevidence forglycosylation ofprocollagenase (1983) (0)
Fibronectin fragments induce aggrecan degradation in human cartilage and are increased in osteoarthritic cartilage (2007) (0)
Understanding the role of ADAM15 in osteoarthritis (2017) (0)
A tribute to Alan J. Barrett. (2003) (0)
Selective targeting of bone and cartilage with multivalent dendritic polyanions (2014) (0)
Biochemical Society Symposium: 70 (2003) (0)
Homophilic complex formation of MT1-matrix metalloproteinase is essential to express collagenolytic activity on the cell surface (2005) (0)
347 GENE EXPRESSION PROFILING OF CARTILAGE DEGRADATION IN A MOUSE MODEL OF OSTEOARTHRITIS IDENTIFIES SIGNIFICANT ALTERATION IN KEY MOLECULAR PROCESSES (2011) (0)
LRP-dependent and -independent internalisation of TIMP-3 (2011) (0)
Erratum: Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing (Journal of Biological Chemistry (2004) 279 (10109-10119)) (2004) (0)
Influence of Matrix Metalloprotease on the Flexibility of Type I Collagen Fibrils Studied By Atomic Force Microscopy (2010) (0)
Preface (2002) (0)
Palmitoylation of MT1-MMP at cysteine 574 in the cytoplasmic tail facilitates its internalisation and modulate cell migration (2004) (0)
Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown (2005) (0)
Homophilic complex formation is prerequisite for MT1‐MMP to degrade type‐I collagen on the cell surface (2004) (0)
Dartmouth medical school ( 1980 – 1983 ) The EI complex vs . proenzyme : a controversy about ‘ latent ’ collagenase In August 1980 (2016) (0)
Proteolytic fragments of tenascin-C promote cartilage degradation (2010) (0)
Crystal structure of the active form (full-length) of human fibroblast collagenase. (2006) (0)
Identification that ADAM17 mediates proteolytic maturation of calcium channel auxiliary α2δ subunits, and enables calcium current enhancement (2021) (0)
Fluorogenic peptide substrates optimized for five human matrix metalloproteinases. (1992) (0)
Knockdown of Tgfβ1 in Alveolar Epithelium-Derived LA-4 Cells Using Replication-Defective Adeno-Associated Virus Carrying Short Hairpin RNA. (2009) (0)
熱ショックによるproMMP-2活性化抑制機構におけるTIMP-2産生調節と熱ショックタンパク質の関与 (1996) (0)
Crystal structure of MT1-MMP hemopexin domain: identification of the dimer interface (2010) (0)
MMPs, ADAMTSs and TIMPs in cartilage matrix breakdown (2001) (0)
Application of Fluorescence Lifetime and Hyperspectral Imaging to Tissue Autofluorescence: Arthritis (2005) (0)
Col2a1-driven TIMP3 disrupts endochondral growth and compromises bone structure and integrity: persistent transgene function in the chondrocyte-to-osteoblast lineage (2016) (0)
Purification And Characterization Of A Neutral Protease From Bovine Nasal Cartilage That Digests Proteoglycans (1977) (0)
The trap hypothesis: alpha2M and protease inhibition (2006) (0)
MMPs and ADAMs as targets for therapies in arthritis (2007) (0)
Linking Transforming Growth Factor Beta Induced Protein (TGFBIp) Turnover to the TGFBI-Associated Corneal Dystrophies (2009) (0)
The Balance of TIMPs and MMP-2 Determines Hepatic Stellate Cell Fate during Recovery from Liver Fibrosis (2003) (0)
Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18–20 April 2004 (2004) (0)
Inhibition of LRP1 shedding reverses cartilage matrix degradation in osteoarthritis (2017) (0)
Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide (2012) (0)
Selective Inhibition of Matrix Metalloproteinase‐2 and ‐9 by Phosphinic Acid Pseudo‐Peptides Containing Triple‐Helical Structure (2006) (0)
Chain register shift in type I collagen alters MMP1 cleavage (2006) (0)
Proteolytic fragments of fibronectin containing the type III-13 and III-14 repeats induce aggrecanase activity in cartilage (2006) (0)
Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change (2010) (0)
Matrix metalloproteinases and their tissue inhibitors at the ovine trophoblast — uterineinterface (2019) (0)
Do Type I Collagen Homotrimers Contribute to Osteoporosis by Altering Bone Remodeling (2008) (0)
The trap hypothesis: α2M and protease inhibition (2006) (0)
Does TIMP-3 protect articular cartilage in OA model (2008) (0)
Distinct roles of the hemopexin and the transmembrane domains as dimer interfaces of MT1-MMP on the cell surface (2007) (0)
Triple-helical collagen unwinding relies on cooperative binding of the catalytic and hemopexin domains of collagenase (2010) (0)
ITOH, YOSHIFUMI (Yoshifumi) (2005) (0)
Identifying synovial tissue-derived catabolic factors of cartilage aggrecan (2013) (0)
Model peptides of interstitial collagens: hydrolysis by matrix metalloproteinases (2002) (0)
Design of a TIMP-3 mutant with an increased half-life for improved protection against cartilage breakdown (2015) (0)
Purification of MMPs and TIMPs. (2001) (0)
Isolation of fibronectin fragments that induce aggrecan degradation in cartilage (2006) (0)
Timp-3 mediates T cell-B cell collaboration by inhibitinp ADAM17/TACE-mediated shedding of CD154. (2006) (0)
THE DIMER INTERFACE OF THE MT1-MMP HEMOPEXIN DOMAIN: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS (2010) (0)
451 UNIQUE FEATURES OF OSM AND ADAMTS5 ON AGGRECAN DEGRADATION (2009) (0)
Chapter 37 Tailoring TIMPs for Selective Metalloproteinase Inhibition (0)
ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells (2019) (0)
膜型MMP(MT1-MMP)によるproMMP-2活性化過程におけるTIMP-2の重要性 (1996) (0)
Influence of specific calmodulin and protein kinase C inhibitors on the interleukin 1 induced collagenase production in human uterine cervical fibroblasts. (1992) (0)
Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets (2022) (0)
TIMP-3 inhibits aggrecan breakdown in pig articular cartilage stimulated with IL-1 (2003) (0)
British Society for Matrix Biology Spring 2017 Meeting: Matrix Proteoglycans: active participants in cell-extracellular matrix communication (2017) (0)
Studies on purified neutral proteoglycan-degrading enzyme (stromelysin/matrix metalloproteinase 3) from human articular cartilage. (1992) (0)
The biology of matrix metalloproteinases and their inhibitors (2002) (0)
Complication of pneumothorax and other side large bulla after Total Hip Arthroplasty:A case report (2018) (0)
Proteinases that Digest the Connective Tissue Matrix (1977) (0)
449 DIFFERENCE GEL ELECTROPHORESIS ANALYSIS OF CARTILAGE DEGRADATION IN A MOUSE MODEL OF OSTEOARTHRITIS IDENTIFIES CHANGES IN KEY MOLECULAR PROCESSES (2011) (0)
Design of selective collagenase3 (MMP-13) inhibitors aspotential therapeutic agents inrheumatoid arthritis (2009) (0)
Voltage-Gated Calcium Channel alpha(2)delta Subunits in Lipid Rafts: The Importance of Proteolytic Cleavage Into alpha(2) and delta (2012) (0)
The interplay between JNK pathway activation, proteoglycan turnover and endocytosis in chondrocytes (2017) (0)
Human collagenase 3 (MMP-13) full form with peptides from pro-domain (2013) (0)
Proteomic analysis of cartilage protein profiles in a mouse model of osteoarthritis (2011) (0)
X-ray structure of human proMMP-1: New insights into collagenase action (2004) (0)
Regulation of fibronectin matrix assembly by tenascin-C (2008) (0)
MT1-MMP in human rheumatoid arthritis (2009) (0)

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