Hidesaburo Hanafusa
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Japanese virologist
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Biology Philosophy
Hidesaburo Hanafusa's Degrees
- PhD Virology University of Tokyo
- Doctorate Medicine University of Tokyo
Why Is Hidesaburo Hanafusa Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hidesaburo Hanafusa was a Japanese virologist. He shared the 1982 Albert Lasker Award for Basic Medical Research with Harold E. Varmus and J. Michael Bishop for demonstrating how RNA tumor viruses cause cancer, and elucidating their role in combining, rescuing and maintaining oncogenes in the viral genome.
Hidesaburo Hanafusa's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- SH2 domains recognize specific phosphopeptide sequences (1993) (2618)
- Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav (1994) (926)
- A novel viral oncogene with structural similarity to phospholipase C (1988) (720)
- TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. (1999) (617)
- Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides (1993) (608)
- Identification of the Product of Growth Arrest-specific Gene 6 as a Common Ligand for Axl, Sky, and Mer Receptor Tyrosine Kinases* (1996) (492)
- Evidence for a transcriptional activation function of BRCA1 C-terminal region. (1996) (478)
- Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus (1983) (461)
- A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation (1984) (397)
- BRCA1 regulates p53-dependent gene expression. (1998) (393)
- c‐Abl kinase regulates the protein binding activity of c‐Crk. (1994) (379)
- Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. (1990) (356)
- Cell transformation by the viral src oncogene. (1987) (350)
- The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant. (1971) (345)
- The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. (1999) (320)
- Cell Transformation by RNA Tumor Viruses (1977) (282)
- Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation (2003) (263)
- Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts (1993) (258)
- Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src. (1994) (240)
- Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. (1995) (238)
- PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1 (2003) (232)
- The defectiveness of Rous sarcoma virus. (1963) (220)
- Analysis of a functional change in membrane in the process of cell transformation by Rous sarcoma virus; alteration in the characteristics of sugar transport. (1970) (218)
- Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. (1997) (206)
- Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein. (1985) (203)
- Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. (1994) (202)
- Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses (1982) (195)
- SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. (1994) (190)
- Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus (1980) (181)
- Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. (2000) (181)
- Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein (1987) (180)
- CMS: an adapter molecule involved in cytoskeletal rearrangements. (1999) (171)
- Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries (1988) (169)
- An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins (1985) (166)
- Association of the polyomavirus middle-T antigen with c-yes protein (1987) (160)
- Phosphatidylinositol kinase activity associates with viral p60src protein (1989) (159)
- Rapid transformation of cells by Rous sarcoma virus. (1969) (159)
- Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. (1984) (158)
- The product of the cellular crk gene consists primarily of SH2 and SH3 regions. (1992) (158)
- Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein (1986) (152)
- v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway (*) (1995) (151)
- Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src (1985) (149)
- ANALYSIS OF THE DEFECTIVENESS OF ROUS SARCOMA VIRUS. 3. DETERMINING INFLUENCE OF A NEW HELPER VIRUS ON THE HOST RANGE AND SUSCEPTIBILITY TO INTERFERENCE OF RSV. (1965) (147)
- Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60 src are dispensable for transformation (1983) (144)
- Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses. (1970) (144)
- Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation. (1987) (144)
- Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. (1997) (140)
- Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. (1990) (139)
- v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation. (2000) (137)
- DNA sequence of the viral and cellular src gene of chickens. II. Comparison of the src genes of two strains of avian sarcoma virus and of the cellular homolog (1982) (136)
- Proteins of helper-dependent RSV. (1971) (136)
- Specific expression of the human cellular fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells. (1985) (133)
- Activation of the transforming potential of p60c-src by a single amino acid change. (1986) (132)
- SH2 and SH3‐containing adaptor proteins: redundant or independent mediators of intracellular signal transduction (1996) (131)
- A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus. (1970) (130)
- Recovery of avian sarcoma virus from tumors induced by transformation- defective mutants (1977) (129)
- A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation (1999) (128)
- Genetic recombination with avian tumor virus. (1972) (128)
- Homology exists among the transforming sequences of avian and feline sarcoma viruses. (1980) (128)
- Noninfectious RSV deficient in DNA polymerase. (1971) (126)
- Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. (1992) (125)
- Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins (1991) (119)
- ANALYSIS OF THE DEFECTIVENESS OF ROUS SARCOMA VIRUS, II. SPECIFICATION OF RSV ANTIGENICITY BY HELPER VIRUS. (1964) (117)
- Characterization of the transforming gene of Fujinami sarcoma virus. (1980) (115)
- Cellular Sequences Related to Three New onc Genes of Avian Sarcoma Virus (fps, yes, and ros) and Their Expression in Normal and Transformed Cells (1982) (115)
- Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation (1990) (115)
- PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis (2004) (114)
- Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus. (1976) (112)
- Abl Interactor 1 Promotes Tyrosine 296 Phosphorylation of Mammalian Enabled (Mena) by c-Abl Kinase* (2003) (111)
- Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways. (1995) (108)
- Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies. (1988) (106)
- Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro. (1992) (105)
- Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein. (1979) (105)
- Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation. (1992) (104)
- Isolation of defective mutant of avian sarcoma virus. (1973) (103)
- DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src (1982) (102)
- Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins. (1995) (102)
- Biological Effects of c-Mer Receptor Tyrosine Kinase in Hematopoietic Cells Depend on the Grb2 Binding Site in the Receptor and Activation of NF-κB (1999) (102)
- Activation of c-Src in cells bearing v-Crk and its suppression by Csk (1992) (99)
- Functional analysis of Csk in signal transduction through the B-cell antigen receptor (1994) (98)
- Direct Binding of p130Cas to the Guanine Nucleotide Exchange Factor C3G* (1998) (98)
- Detection of Avian Tumor Virus RNA in Uninfected Chicken Embryo Cells (1973) (97)
- DNA in uninfected and virus-infected cells complementary to avian tumor virus RNA. (1971) (97)
- The proto-oncogene of v-eyk (v-ryk) is a novel receptor-type protein tyrosine kinase with extracellular Ig/GN-III domains. (1994) (95)
- The Adapter Type Protein CMS/CD2AP Binds to the Proto-oncogenic Protein c-Cbl through a Tyrosine Phosphorylation-regulated Src Homology 3 Domain Interaction* (2001) (94)
- Existence and expression of tumor virus genes in chick embryo cells. (1972) (92)
- A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein (1982) (91)
- Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity (1982) (90)
- The SH3 Domain of Crk Binds Specifically to a Conserved Proline-rich Motif in Eps15 and Eps15R (*) (1995) (90)
- Further studies on RSV production form transformed cells. (1968) (89)
- Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src (1996) (88)
- N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene (1985) (86)
- Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region (1987) (85)
- Fine structural mapping of a critical NH2-terminal region of p60src. (1985) (85)
- Phosphatidylinositol kinase type I activity associates with various oncogene products. (1989) (84)
- The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. (1992) (84)
- Unique signal transduction of Eyk: constitutive stimulation of the JAK‐STAT pathway by an oncogenic receptor‐type tyrosine kinase. (1996) (84)
- Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein. (1992) (82)
- Recombination between viral and cellular sequences generates transforming sarcoma virus. (1978) (82)
- Changes in amino-terminal sequences of pp60src lead to decreased membrane association and decreased in vivo tumorigenicity (1982) (81)
- Determining factor in the capacity of Rous sarcoma virus to induce tumors in mammals. (1966) (81)
- Genetic Variation in the RNA Transcripts of Endogenous Virus Genes in Uninfected Chicken Cells (1977) (80)
- Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways (1994) (79)
- ANALYSIS OF THE DEFECTIVENESS OF ROUS SARCOMA VIRUS. I. CHARACTERIZATION OF THE HELPER VIRUS. (1964) (78)
- Only membrane-associated RSV src proteins have amino-terminally bound lipid (1983) (78)
- v-Crk Activates the Phosphoinositide 3-Kinase/AKT Pathway by Utilizing Focal Adhesion Kinase and H-Ras (2002) (78)
- Hydrazinolysis of Peptides and Proteins. II. Fundamental Studies on the Determination of the Carboxyl-ends of Proteins (1956) (77)
- Processing of 9E3 mRNA and regulation of its stability in normal and Rous sarcoma virus-transformed cells (1989) (77)
- Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G (1998) (76)
- Processing of p60v-src to its myristylated membrane-bound form (1985) (75)
- Microinjection analysis of envelope-glycoprotein messenger activities of avian leukosis viral RNAs. (1977) (74)
- Absence of Polymerase Protein in Virions of Alpha-Type Rous Sarcoma Virus (1972) (73)
- Activation of Rho-Dependent Cell Spreading and Focal Adhesion Biogenesis by the v-Crk Adaptor Protein (1998) (73)
- Requirement of phosphatidylinositol-3 kinase modification for its association with p60src (1991) (72)
- Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain (1990) (70)
- Penetration and intracellular release of the genomes of avian RNA tumor viruses. (1972) (69)
- The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1. (2000) (68)
- Characterization of avian and viral p60src proteins expressed in yeast. (1987) (68)
- Guanine-Nucleotide Exchange Protein C3G Activates JNK1 by a Ras-independent Mechanism (1998) (68)
- Closing in on SH2 specificity. (1993) (68)
- Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein (1981) (67)
- Oncogenicity of avian leukosis viruses of different subgroups and of mutants of sarcoma viruses (1977) (66)
- Transformation of chicken embryo fibroblasts and tumor induction by the middle T antigen of polyomavirus carried in an avian retroviral vector (1986) (66)
- Cellular proteins homologous to the viral yes gene product (1986) (66)
- Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix (1991) (66)
- RNA of replication-defective strains of Rous sarcoma virus. (1975) (66)
- A type of chick embryo cell that fails to support formation of infectious RSV. (1970) (66)
- Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length (1977) (66)
- A novel oncogene, v-ryk, encoding a truncated receptor tyrosine kinase is transduced into the RPL30 virus without loss of viral sequences (1992) (61)
- Csk enhances insulin-stimulated dephosphorylation of focal adhesion proteins (1996) (60)
- Isolation of leukosis-type virus from pheasant embryo cells: possible presence of viral genes in cells. (1973) (60)
- Augmentation of metalloproteinase (gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src. (1995) (59)
- p60c-src is complexed with a cellular protein in subcellular compartments involved in exocytosis (1988) (59)
- A fps gene without gag gene sequences transforms cells in culture and induces tumors in chickens (1983) (58)
- Plaque assay for some strains of avian leukosis virus. (1972) (57)
- Crk family adaptor proteins trans‐activate c‐Abl kinase (2001) (56)
- Detection of a Protein of Avian Leukoviruses in Uninfected Chick Cells by Radioimmunoassay (1974) (56)
- Avian erythroblastosis virus produces two mRNA's (1980) (56)
- Genetic structure, transforming sequence, and gene product of avian sarcoma virus UR1 (1981) (56)
- Activation of the transformation potential of the cellular fps gene (1985) (55)
- CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas. (2004) (55)
- Cytoplasmic localization of the transforming protein of Fujinami sarcoma virus: salt-sensitive association with subcellular components (1983) (55)
- DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains (1984) (54)
- Phosphatidylinositol-3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts. (1991) (54)
- Differential developmental expression of cellular yes and cellular src proteins in cerebellum. (1988) (52)
- Presence of antigen common to avian tumor viral envelope antigen in normal chick embryo cells. (1973) (51)
- Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS–MAPK pathway and RAP1 (1999) (51)
- Mutants of Fujinami sarcoma virus which are temperature sensitive for cellular transformation and protein kinase activity (1981) (49)
- Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells (1985) (49)
- Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog (1981) (48)
- Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C. (1988) (48)
- Molecular Cloning of the Fujinami Sarcoma Virus Genome and Its Comparison with Sequences of Other Related Transforming Viruses (1982) (47)
- Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants (1986) (47)
- Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters (1986) (47)
- Killing of L- cells by heat- and UV- inactivated vaccinia virus. (1960) (47)
- Transforming genes of avian (v-fps) and mammalian (v-fes) retroviruses correspond to a common cellular locus. (1983) (46)
- Induction of neoplasms by subgroup E recombinants of exogenous and endogenous avian retroviruses (Rous-associated virus type 60) (1980) (46)
- Biochemical properties of p60v-src mutants that induce different cell transformation parameters (1986) (45)
- The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation (1987) (44)
- A Novel Ligand for SH3 Domains (1995) (44)
- Proposal for Numbering Mutants of Avian Leukosis and Sarcoma Viruses (1974) (44)
- Recombination between endogenous and exogenous RNA tumor virus genes as analyzed by nucleic acid hybridization (1975) (43)
- v-Crk-induced cell transformation: changes in focal adhesion composition and signaling. (1997) (43)
- Absence of surface projections of some noninfectious forms of RSV. (1975) (42)
- Polymerization of Aminoacetonitrile (1959) (42)
- Genetic control of expression of endogenous virus genes in chicken cells. (1974) (41)
- Common BRCA1 variants and transcriptional activation. (1997) (41)
- Comparative study of three protein-tyrosine phosphatases. Chicken protein-tyrosine phosphatase lambda dephosphorylates c-Src tyrosine 527. (1994) (41)
- Genetic structure and transforming sequence of avian sarcoma virus UR2 (1982) (40)
- Avian Tumor Virus Proteins and RNA in Uninfected Chicken Embryo Cells (1974) (40)
- Synethesis and integration of viral DNA in chicken cells at different time after infection with various multiplicities of avian oncornavirus (1976) (40)
- Comparison of the small RNAs of polymerase-deficient and polymerase-positive Rous sarcoma virus and another species of avian retrovirus (1979) (40)
- Deoxyribonucleic Acid Polymerase Activities in Normal and Leukovirus-Infected Chicken Embryo Cells (1972) (39)
- Size-variant pp60src proteins of recovered avian sarcoma viruses interact with adhesion plaques as peripheral membrane proteins: effects on cell transformation (1984) (38)
- Characterization of some isolates of newly recovered avian sarcoma virus (1979) (38)
- Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses (1985) (37)
- Inactivation of c-Yes tyrosine kinase by elevation of intracellular calcium levels (1993) (37)
- gag-Related polypeptides encoded by replication-defective avian oncoviruses (1979) (35)
- Serum and v-src increase the level of a CCAAT-binding factor required for transcription from a retroviral long terminal repeat. (1990) (35)
- Structural protein markers in the avian oncoviruses (1977) (35)
- Role of p60src kinase activity in the induction of neuroretinal cell proliferation by rous sarcoma virus (1982) (32)
- Nuclear conversion of microinjected avian leukosis virion RNA into an envelope-glycoprotein messenger (1978) (32)
- Modulation of arachidonic acid metabolism by Rous sarcoma virus (1989) (31)
- Detection of a Physical and Functional Interaction between Csk and Lck Which Involves the SH2 Domain of Csk and Is Mediated by Autophosphorylation of Lck on Tyrosine 394 (*) (1996) (31)
- Evidence for the common origin of viral and cellular sequences involved in sarcomagenic transformation (1980) (31)
- Avian RNA Tumor Viruses (1975) (31)
- Analysis of the src gene of sarcoma viruses generated by recombination between transformation-defective mutants and quail cellular sequences (1979) (30)
- Effect of rifampicin and a derivative on cells transformed by Rous sarcoma virus. (1971) (29)
- The v-src inducible gene 9E3/pCEF4 is regulated by both its promoter upstream sequence and its 3' untranslated region. (1991) (29)
- Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells (1985) (29)
- Intracellular precursors to the major glycoprotein of avian oncoviruses in chicken embryo fibroblasts (1978) (29)
- Temperature-sensitive membrane association of pp60src in tsNY68-infected cells correlates with increased tyrosine phosphorylation of membrane-associated proteins. (1983) (29)
- Electrophoretic analysis of the RNA of avian tumor viruses. (1972) (28)
- Antipeptide antiserum identifies a widely distributed cellular tyrosine kinase related to but distinct from the c-fps/fes-encoded protein (1986) (28)
- Tryptic peptide analysis of avian oncovirus gag and pol gene products (1979) (28)
- Pheasant virus: new class of ribodeoxyvirus. (1976) (28)
- A novel muscle LIM‐only protein is generated from the paxillin gene locus in Drosophila (2001) (28)
- Cell to substratum adhesion is involved in v-Src-induced cellular protein tyrosine phosphorylation: implication for the adhesion-regulated protein tyrosine phosphatase activity (1997) (27)
- The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. (2000) (27)
- Independent regulation of endogenous and exogenous avian RNA tumor virus genes. (1976) (27)
- Crk Associates with ERM Proteins and Promotes Cell Motility toward Hyaluronic Acid* (2004) (26)
- Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk. (1996) (26)
- A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-Crk signaling (2002) (26)
- A transmembrane protein-tyrosine phosphatase contains spectrin-like repeats in its extracellular domain. (1994) (25)
- Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene (1985) (25)
- Isolation of 16L virus: a rapidly transforming sarcoma virus from an avian leukosis virus-induced sarcoma. (1982) (25)
- Complementation of functions required for cell transformation by double infection with RSV mutants. (1972) (25)
- Partial nucleotide sequence of Rous sarcoma virus-29 provides evidence that the original Rous sarcoma virus was replication defective (1985) (25)
- Avian sarcoma viruses. (1988) (24)
- Possible v-Crk-induced Transformation through Activation of Src Kinases (*) (1995) (23)
- The Ras-MAPK pathway downregulates Caveolin-1 in rodent fibroblast but not in human fibroblasts: implications in the resistance to oncogene-mediated transformation (2007) (23)
- Two independent mutations are required for temperature-sensitive cell transformation by a Rous sarcoma virus temperature-sensitive mutant (1985) (22)
- Identification and evaluation of new primer sets for the detection of lentivirus proviral DNA. (1992) (22)
- Characterization of chicken protein tyrosine phosphatase alpha and its expression in the central nervous system. (1996) (22)
- A role for Ras in v-Crk transformation. (1996) (22)
- Activation of the c-src Gene (1986) (21)
- Identification of the viral sequence required for the generation of recovered avian sarcoma viruses and characterization of a series of replication-defective recovered avian sarcoma viruses (1984) (21)
- NH2-terminal sequences of two src proteins that cause aberrant transformation. (1987) (21)
- Analysis of defectiveness of Rous sarcoma virus. IV. Kinetics of RSV production. (1966) (21)
- A 31-amino-acid N-terminal extension regulates c-Crk binding to tyrosine-phosphorylated proteins (1993) (21)
- Genetic Structure and Transforming Sequence of Avian Sarcoma Virus UR 2 (20)
- Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src (1992) (20)
- Interaction among avian tumor viruses giving enhanced infectivity. (1967) (20)
- Revertants and partial transformants of rat fibroblasts infected with Fujinami sarcoma virus (1984) (19)
- A glycoprotein in the plasma membrane matrix as a major potential substrate of p60v-src (1990) (19)
- Control expression of tumor virus genes in uninfected chicken cells. (1975) (18)
- Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability (1990) (17)
- Polymerase-defective mutant of the Bryan high-titer strain of Rous sarcoma virus. (1986) (17)
- Virus production by Rous sarcoma cells. (1970) (17)
- CrkII induces serum response factor activation and cellular transformation through its function in Rho activation (2003) (17)
- Transformation of ectromelia into vaccinia virus in tissue culture. (1959) (17)
- Delay in serum stimulation of Erk activity caused by oncogenic transformation. (1996) (17)
- Factors involved in the initiation of multiplication of vaccinia virus. (1962) (17)
- Detection of SH3-binding proteins in total cell lysates with glutathione S-transferase-SH3 fusion proteins: SH3 blot assay. (1995) (16)
- Membrane association of the transforming protein of avian sarcoma virus UR2 and mutants temperature sensitive for cellular transformation and protein kinase activity (1985) (16)
- Localization of major potential substrates of p60v-src kinase in the plasma membrane matrix fraction. (1989) (16)
- In vivo phosphorylation states and kinase activities of transforming p60c-src mutants. (1989) (16)
- FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts. (2006) (16)
- Signaling adaptor protein v-Crk activates Rho and regulates cell motility in 3Y1 rat fibroblast cell line. (2002) (16)
- Recombination between a temperature-sensitive mutant and a deletion mutant of Rous sarcoma virus (1976) (15)
- Relationship between A-type and C-type particles in cells infected by Rous sarcoma virus. (1975) (15)
- Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene. (1988) (15)
- Formation of reticuloendotheliosis virus pseudotypes of Rous sarcoma virus (1977) (13)
- Expression of 9E3 mRNA is associated with mitogenicity, phosphorylation, and morphological alteration in chicken embryo fibroblasts (1990) (13)
- DIFFERENTIAL RESPONSIVENESS OF ROUS SARCOMA VIRUS STOCKS TO SPECIFIC CELLULAR RESISTANCE INDUCED BY AVIAN LEUKOSIS VIRUSES. (1964) (13)
- 3 – Transformation by Rous Sarcoma Virus (1989) (13)
- Loss of c-abl facilitates anchorage-independent growth of p53- and RB- deficient primary mouse embryonic fibroblasts (2004) (13)
- Analysis of p60v-src mutants carrying lesions involved in temperature sensitivity (1987) (13)
- Robotics research: The second international symposium (1985) (12)
- THE NATURE AND ORIGIN OF THE TRANSFORMING GENE OF AVIAN SARCOMA VIRUSES (1980) (12)
- Comparative analysis of cellular and viral sequences related to sarcomagenic cell transformation. (1980) (11)
- Morphological transformation, tumorigenicity and src-specific cytotoxic T-lymphocyte-mediated tumor immunity induced by murine 3T3 cells expressing src oncogenes encoding novel non-myristylated N-terminal domains. (1993) (11)
- Isolation of chicken cellular DNA sequences with homology to the region of viral oncogenes that encodes the tyrosine kinase domain (1986) (11)
- src-specific immune regression of Rous sarcoma virus-induced tumors. (1993) (11)
- Comparative study of three protein-tyrosine phosphatases. Chicken protein-tyrosine phosphatase lambda dephosphorylates c-Src tyrosine 527. J Biol Chem 269, 20194-20200 (1994) (10)
- Identification and Characterization of a High-Affinity Interaction between v-Crk and Tyrosine-Phosphorylated Paxillin in CT 10-Transformed Fibroblasts (2003) (10)
- Integration of Rous sarcoma virus DNA into chicken embryo fibroblasts: no preferred proviral acceptor site in the DNA of clones of singly infected transformed chicken cells (1981) (10)
- Transforming protein encoded by the cellular information of recovered avian sarcoma viruses. (1980) (10)
- v-src transformation of rat embryo fibroblasts. Inefficient conversion to anchorage-independent growth involves heterogeneity of primary cultures (1994) (10)
- v-Crk, an effector of the nerve growth factor signaling pathway, delays apoptotic cell death in neurotrophin-deprived PC12 cells (1996) (9)
- c-yes protein kinase is associated with a 38 kD protein in cerebellum. (1991) (9)
- Sequences and functions of Rous sarcoma virus RNA. (1976) (9)
- TRANSCRIPTION OF THE AVIAN RNA TUMOR VIRUS GLYCOPROTEIN GENE IN UNINFECTED AND INFECTED CELLS (1976) (9)
- Suppression of v-Src transformation in primary rat embryo fibroblasts. (1995) (9)
- Replication of oncogenic viruses in virus-induced tumor cells-their persistence and interaction with other viruses. (1969) (9)
- Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras (2005) (9)
- Serum independence of transcription from the promoter of an avian retrovirus in v-src-transformed cells is a primary, intracellular effect of increased tyrosine phosphorylation. (1990) (9)
- Transformation Phenomena in the Pox Group Viruses. II. Transformation between Several Members of Pox Group. (1959) (8)
- Characterization of avian erythroblastosis virus p75. (1982) (7)
- Transformation Phenomena in the Pox Group Viruses. I. Transformation of Ectromelia into Vaccinia Virus in Tissue Culture. (1959) (7)
- Structural studies on oncornavirus-related sequences in chicken genomic DNA: two-step analyses of EcoRI and Bgl I restriction digests and tentative mapping of a ubiquitous endogenous provirus digests and tentative mapping of a ubiquitous endogenous provirus. (1979) (7)
- Purification and characterization of P47gag-crk expressed in insect cells. (1990) (7)
- Activation of a histone H1 kinase by tyrosine phosphorylation in v‐src‐transformed fibroblasts. (1993) (6)
- A quantitative electron microscopic study of the virus particles found in cells infected with Rous sarcoma virus. (1968) (6)
- Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies (1988) (6)
- Suppression of Rous sarcoma virus-induced tumor formation by preinfection with viruses encoding src protein with novel N termini (1989) (5)
- Human Diploid Fibroblasts are Refractory to Oncogene-Mediated Transformation (2004) (5)
- A New Method for Ultra Micro Determination of Ammonia or Organic Nitrogen (1954) (5)
- STUDIES ON TAKA-AMYLASE A:II. AMINO ACID COMPOSION OF TAKA-AMYLASE A (1954) (4)
- Formation of Rous associated virus-60: origin of the polymerase gene (1979) (4)
- Cellular origin of transforming genes of RNA tumor viruses. (1979) (4)
- Cell transformation by an oncogene that regulates protein kinases. (1990) (4)
- Advances in Brief The Ras-Mitogen-activated Protein Kinase Pathway Is Critical for the Activation of Matrix Metalloproteinase Secretion and the Invasiveness in v-crk-transformed 3 Y 11 (2000) (3)
- Specific expression of the human cellular fps / fes-encoded protein NCP 92 in normal and leukemic myeloid cells ( myeloid differentiation / myelomonocytic leukemia / colony-stimulating factor / tyrosine kinase ) (3)
- Functional Analysis ofCskinSignal Transduction through theB-Cell Antigen Receptor (1994) (2)
- Transformation by p60src with altered N-terminal sequences. (1986) (2)
- Activation of the Drosophila C 3 G leads to cell fate changes and overproliferation during development , mediated by the RAS – MAPK pathway and RAP 1 (2013) (2)
- Protein phosphorylation and cell transformation. (1991) (2)
- Production of avian oncoviral subgroups after multiple infection (1979) (1)
- The putative trans-activator in the MAgag region of Rous sarcoma virus is not required for cell transformation (1988) (1)
- The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels (1992) (1)
- Deoxyribonucleic AcidPolymerase Activities in NormalandLeukovirus-Infec ted Chicken EmbryoCells (1972) (1)
- Activation of YRP kinase by v-Src and protein kinase C-mediated signal transduction pathways. (1995) (1)
- Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras (2005) (1)
- Functional and Structural Analysis of the v-src and c-src Genes (1987) (1)
- Evidence fortheCommonOrigin ofViral andCellular Sequences Involved inSarcomagenic Transformation (1980) (1)
- A Glycoprotein in the Plasma Membrane (2003) (0)
- Reactivation phenomena in the pox group viruses,pt.3. (1960) (0)
- Roussarcoma virus variants thatcarry thecellular srcgeneinstead oftheviral srcgenecannot transform chicken embryofibroblasts (proto-oncogene/transfection/transformation) (1984) (0)
- protein . but distinct from the c-fps / fes-encoded distributed cellular tyrosine kinase related to Antipeptide antiserum identifies a widely (2003) (0)
- Intracellular Precursors totheMajorGlycoprotein ofAvian Oncoviruses inChicken EmbryoFibroblasts (1978) (0)
- Abstract A44: Src‐induced human cell transformation (2009) (0)
- LackofInduction ofNeuroretinal CellProliferation byRous Sarcoma Virus Variants ThatCarrythec-srcGene (1985) (0)
- [An interview with Dr. Hidesaburo Hanafusa in honor of his cultural medal]. (1996) (0)
- Pheasant virus: New class of ribodeoxyvirus proteins/DNA.RNA hybridization/RNA-dependent DNA polymerase (nucleotidyltransferase)/helper virus] (0)
- Transformations of Myxoma into Vaccinia or Ectromelia Virus in Tissue Culture (1959) (0)
- Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging (2013) (0)
- Proposal forNumbering Mutants ofAvianLeukosis and SarcomaViruses (1974) (0)
- DNA Sequence oftheBryanHigh-Titer Strain ofRousSarcoma Virus: Extent ofenv Deletion andPossible Genealogical Relationship withOtherViral Strains (1984) (0)
- A NovelOncogene, v-ryk, Encoding aTruncated Receptor Tyrosine Kinase IsTransduced intotheRPL30Virus without LossofViral Sequences (1992) (0)
- Transforming Genes of RNA Tumor Viruses (1983) (0)
- Activation oftheProto-Oncogene p60c-src byPoint Mutations intheSH2Domain (1990) (0)
- Biological andBiochemical Activity ofv-CrkChimeras Containing theSH2/SH3Regions ofPhosphatidylinositol-Specific Phospholipase C--y andSrc (1992) (0)
- Oncogenicity ofAvianLeukosis Viruses ofDifferent Subgroups andofMutants ofSarcoma Viruses (1977) (0)
- Affinity andspecificity requirements forthefirst Src homology3domainoftheCrkproteins (1995) (0)
- Increased tyrosine kinase activity of cSrc during calcium-induced keratinocyte differentiation ( non-receptor-type tyrosine kinase / epidermis / protein trosine phosphatase / protooncogene ) (0)
- Src: c-Src protein-tyrosine kinase (vertebrates) (1995) (0)
- EARLY DEVELOPMENTS IN RESEARCH ON TRANSFORMING RETROVIRUSES (1999) (0)
- Isolation ofDefective MutantofAvianSarcomaVirus (recombination/RNA-dependent DNA polymerase/glycoprotein/endogenous virus) (1973) (0)
- Requirement ofPhosphatidylinositol-3 (1991) (0)
- [Studies on the Src protein]. (1995) (0)
- Suppression ofRousSarcomaVirus-Induced TumorFormation byPreinfection withViruses Encoding srcProtein with NovelN Termini (1989) (0)
- Guanine-Nucleotide Exchange Protein C 3 G Activates JNK 1 by a Ras-independent Mechanism JNK 1 ACTIVATION INHIBITED BY KINASE (1998) (0)
- A Short Sequence inthep6Osrc N Terminus IsRequired forp6Osrc Myristylation andMembraneAssociation andforCell Transformation (1984) (0)
- Cell surface antigens of type C RNA viruses as markers for detection of viruses. (1975) (0)
- Location of envelope-specific and other sequences on the RNA of Schmidt-Ruppin Rous sarcoma virus. (1976) (0)
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