Hideyoshi Harashima
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Computer Science
Hideyoshi Harashima's Degrees
- PhD Computer Science Kyoto University
- Masters Artificial Intelligence Imperial University of Japan
- Bachelors Computer Engineering Osaka University
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(Suggest an Edit or Addition)Hideyoshi Harashima's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (2006) (1208)
- A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. (2011) (564)
- Stearylated arginine-rich peptides: a new class of transfection systems. (2001) (434)
- Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment (2009) (432)
- Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid (2007) (373)
- High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression* (2006) (362)
- The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus. (2015) (353)
- The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors. (2013) (334)
- Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system. (2004) (270)
- Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides. (2012) (254)
- MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. (2008) (239)
- A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. (2009) (235)
- Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method. (2004) (233)
- A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo. (2012) (232)
- Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis. (2013) (230)
- Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. (2006) (212)
- Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. (2008) (211)
- Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes (1994) (209)
- Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery (2006) (208)
- Liposome Clearance (2002) (197)
- Octaarginine-modified multifunctional envelope-type nano device for siRNA. (2007) (190)
- Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. (2011) (181)
- Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization. (2003) (181)
- Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery. (2011) (178)
- Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery (2007) (174)
- Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation (2004) (174)
- Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system. (2008) (172)
- Octaarginine- and Octalysine-modified Nanoparticles Have Different Modes of Endosomal Escape* (2008) (169)
- Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy. (2004) (163)
- Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems☆ (2018) (161)
- Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes. (2007) (160)
- Pharmacokinetics and brain uptake of lactoferrin in rats. (2006) (150)
- Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo. (2004) (149)
- Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells. (2007) (147)
- Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots. (2008) (145)
- Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system (2014) (145)
- Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. (2015) (136)
- Pharmacokinetic and pharmacodynamic considerations in gene therapy. (2003) (126)
- Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process. (2009) (126)
- A new adjuvant delivery system 'cyclic di-GMP/YSK05 liposome' for cancer immunotherapy. (2014) (116)
- An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives (2008) (114)
- Learning from the Viral Journey: How to Enter Cells and How to Overcome Intracellular Barriers to Reach the Nucleus (2009) (110)
- Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex (2007) (108)
- Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system. (2013) (108)
- Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria. (2007) (107)
- Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery. (2011) (105)
- Intracellular trafficking and transgene expression of viral and non-viral gene vectors. (2001) (105)
- Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA. (2011) (103)
- Lipoplex size determines lipofection efficiency with or without serum (2003) (103)
- RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system. (2014) (100)
- Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin. (2006) (99)
- Computer Simulation of the Effects of Alterations in Blood Flows and Body Composition on Thiopental Pharmacokinetics in Humans (1997) (98)
- Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes. (2008) (96)
- Reprint of: Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation. (2010) (93)
- Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy. (2012) (92)
- Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: programmed endosomal escape and dissociation. (2010) (92)
- Quantitative Analysis of Correlation Between Number of Nuclear Plasmids and Gene Expression Activity After Transfection with Cationic Liposomes (2002) (91)
- No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA. (2003) (89)
- New NTP analogs: the synthesis of 4′-thioUTP and 4′-thioCTP and their utility for SELEX (2005) (88)
- Octaarginine-modified liposomes: enhanced cellular uptake and controlled intracellular trafficking. (2008) (88)
- Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy. (2005) (87)
- Understanding structure‐activity relationships of pH‐sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo (2019) (87)
- Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: The use of a nuclear transfer score (2005) (85)
- A multifunctional envelope-type nanodevice for use in nanomedicine: concept and applications. (2012) (83)
- A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells. (2016) (82)
- Multifunctional envelope-type nano device for non-viral gene delivery: concept and application of Programmed Packaging. (2007) (81)
- Prediction of the volumes of distribution of basic drugs in humans based on data from animals (1984) (80)
- The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells. (2013) (80)
- Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: qualitative and quantitative evaluation of intracellular trafficking. (1998) (79)
- Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers (2017) (78)
- Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape. (2009) (77)
- Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery (2018) (77)
- Interactions of liposomes with cells in vitro and in vivo: opsonins and receptors. (2001) (76)
- Heterogeneity of tumor endothelial cells and drug delivery. (2016) (76)
- Mitochondrial delivery of Coenzyme Q10 via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver. (2015) (75)
- Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue. (2010) (75)
- RNA interference induced by siRNAs modified with 4′‐thioribonucleosides in cultured mammalian cells (2005) (75)
- Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery to the pulmonary endothelium. (2013) (75)
- The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration. (2013) (74)
- Unique features of a pH‐sensitive fusogenic peptide that improves the transfection efficiency of cationic liposomes (2005) (73)
- Liposomal targeting and drug delivery: kinetic consideration (1996) (72)
- Erroneous incorporation of oxidized DNA precursors by Y‐family DNA polymerases (2003) (72)
- Comparative tissue concentration profiles of fentanyl and alfentanil in humans predicted from tissue/blood partition data obtained in rats. (1990) (72)
- Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter. (2012) (71)
- Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery. (2011) (70)
- Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors. (2001) (69)
- Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes. (2010) (68)
- Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. (2002) (67)
- A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids. (2005) (67)
- Cell penetrating peptide-mediated systemic siRNA delivery to the liver. (2011) (66)
- Effects of the size and fluidity of liposomes on their accumulation in tumors: A presumption of their interaction with tumors (1995) (65)
- Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery. (2016) (64)
- Nanoparticulation of BCG-CWS for application to bladder cancer therapy. (2014) (64)
- FRET from quantum dots to photodecompose undesired acceptors and report the condensation and decondensation of plasmid DNA. (2012) (63)
- A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway. (2008) (62)
- Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis. (2011) (61)
- Vascular-targeted nanotherapy for obesity: unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery. (2012) (61)
- Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature. (2006) (60)
- STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation (2021) (60)
- Intracellular control of gene trafficking using liposomes as drug carriers. (2001) (59)
- Glycerol Monomycolate Is a Novel Ligand for the Human, but Not Mouse Macrophage Inducible C-type Lectin, Mincle* (2014) (59)
- Supramolecular control of polyplex dissociation and cell transfection: efficacy of amino groups and threading cyclodextrins in biocleavable polyrotaxanes. (2008) (59)
- A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure (2015) (58)
- The effect of size and charge of lipid nanoparticles prepared by microfluidic mixing on their lymph node transitivity and distribution. (2020) (57)
- FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice. (2016) (57)
- Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond. (2017) (56)
- Size dependent liposome degradation in blood: in vivo/in vitro correlation by kinetic modeling. (1995) (56)
- Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. (2006) (56)
- An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells. (2014) (55)
- Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake. (2010) (55)
- Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling. (1999) (54)
- KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine. (2011) (54)
- Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei (2006) (53)
- Visualization of intracellular trafficking of exogenous DNA delivered by cationic liposomes. (2002) (53)
- General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation. (2015) (52)
- Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines (2016) (52)
- Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. (2010) (51)
- Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells. (2016) (51)
- Involvement of Y-Family DNA Polymerases in Mutagenesis Caused by Oxidized Nucleotides in Escherichia coli (2006) (50)
- A Neutral Envelope‐Type Nanoparticle Containing pH‐Responsive and SS‐Cleavable Lipid‐Like Material as a Carrier for Plasmid DNA (2013) (50)
- Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells. (2002) (49)
- Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection. (2016) (49)
- A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma. (2015) (49)
- Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis. (2010) (49)
- Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell‐mediated lipid nanoparticle‐associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus (2017) (47)
- In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus. (2014) (47)
- Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine-modified gene vector in CD44 positive- and CD44 negative-cells. (2015) (46)
- Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors. (2016) (45)
- The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine. (2013) (45)
- Mitochondrial delivery of antisense RNA by MITO-Porter results in mitochondrial RNA knockdown, and has a functional impact on mitochondria. (2015) (44)
- Intranuclear disposition of exogenous DNA in vivo: Silencing, methylation and fragmentation (2006) (44)
- Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer (2019) (44)
- Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo. (2014) (44)
- Clinical Translation of Nanomedicines: Challenges, Opportunities, and Keys. (2021) (44)
- Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system. (2009) (44)
- In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle (2013) (44)
- Development of lipid particles targeted via sugar-lipid conjugates as novel nuclear gene delivery system. (2008) (43)
- Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy. (2020) (43)
- Validation of Gene Therapy for Mutant Mitochondria by Delivering Mitochondrial RNA Using a MITO-Porter (2020) (43)
- 2-Methacryloyloxyethyl phosphorylcholine polymer (MPC)-coating improves the transfection activity of GALA-modified lipid nanoparticles by assisting the cellular uptake and intracellular dissociation of plasmid DNA in primary hepatocytes. (2010) (43)
- Reducing the Cytotoxicity of Lipid Nanoparticles Associated with a Fusogenic Cationic Lipid in a Natural Killer Cell Line by Introducing a Polycation-Based siRNA Core. (2018) (43)
- Suppression of spontaneous and hydrogen peroxide‐induced mutations by a MutT‐type nucleotide pool sanitization enzyme, the Escherichia coli Orf135 protein (2003) (42)
- Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney. (1999) (42)
- Dawn of lipid nanoparticles in lymph node targeting: Potential in cancer immunotherapy. (2020) (42)
- The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice. (2014) (41)
- A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant (2015) (41)
- A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication. (2013) (41)
- In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration. (2018) (41)
- Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin‐induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium (2018) (41)
- Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388. (1999) (40)
- In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP). (2007) (40)
- Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression (2007) (40)
- Significant and prolonged antisense effect of a multifunctional envelope‐type nano device encapsulating antisense oligodeoxynucleotide (2006) (40)
- Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells. (2007) (40)
- Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes (2014) (40)
- Non-linear pharmacodynamics in a non-viral gene delivery system: positive non-linear relationship between dose and transfection efficiency. (2006) (40)
- Advances in an active and passive targeting to tumor and adipose tissues (2015) (40)
- Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference. (2011) (39)
- Application of a fusiogenic peptide GALA for intracellular delivery. (2011) (39)
- Development of a Novel DNA Aptamer Ligand Targeting to Primary Cultured Tumor Endothelial Cells by a Cell-Based SELEX Method (2012) (39)
- Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect (2012) (39)
- Comparison between in‐vivo and in‐vitro tissue‐to‐plasma unbound concentration ratios (Kp,f) of quinidine in rats (1984) (39)
- An apolipoprotein E modified liposomal nanoparticle: ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells. (2014) (39)
- Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition. (2020) (39)
- Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine. (2010) (39)
- Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter. (2013) (38)
- Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells. (2009) (38)
- Synergistic Effect Between Size and Cholesterol Content in the Enhanced Hepatic Uptake Clearance of Liposomes Through Complement Activation in Rats (1996) (38)
- Improved Cell Viability of Linear Polyethylenimine through γ‐Cyclodextrin Inclusion for Effective Gene Delivery (2006) (38)
- Improvement of doxorubicin efficacy using liposomal anti-polo-like kinase 1 siRNA in human renal cell carcinomas. (2014) (38)
- Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice* (2015) (38)
- Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier. (2013) (38)
- Evaluation of the nuclear delivery and intra‐nuclear transcription of plasmid DNA condensed with µ (mu) and NLS‐µ by cytoplasmic and nuclear microinjection: a comparative study with poly‐L‐lysine (2006) (37)
- Comparative study of the sensitivities of cancer cells to doxorubicin, and relationships between the effect of the drug-efflux pump P-gp. (2014) (37)
- Synergism between a cell penetrating peptide and a pH‐sensitive cationic lipid in efficient gene delivery based on double‐coated nanoparticles (2018) (37)
- Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription. (2009) (37)
- Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid‐mediated transgene expression (2007) (37)
- Saturable, Non‐Michaelis‐Menten Uptake of Liposomes by the Reticuloendothelial System (1991) (36)
- Noninvasive and efficient transdermal delivery of CpG-oligodeoxynucleotide for cancer immunotherapy. (2011) (36)
- Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues. (2010) (36)
- Hydrolysis of oxidized nucleotides by the Escherichia coli Orf135 protein. (2001) (36)
- Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta. (2007) (36)
- Challenges in Promoting Mitochondrial Transplantation Therapy (2020) (35)
- The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy (2019) (35)
- The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice. (2014) (35)
- Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency (1993) (35)
- Therapeutic assessment of cytochrome C for the prevention of obesity through endothelial cell-targeted nanoparticulate system. (2013) (34)
- The therapeutic effects of R8-liposome-BCG-CWS on BBN-induced rat urinary bladder carcinoma. (2011) (34)
- Validation of Mitochondrial Gene Delivery in Liver and Skeletal Muscle via Hydrodynamic Injection Using an Artificial Mitochondrial Reporter DNA Vector. (2015) (34)
- Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus. (2010) (34)
- Power of mitochondrial drug delivery systems to produce innovative nanomedicines. (2020) (34)
- A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mitochondrial RNA Aptamer Synergistically Facilitates Cellular Uptake and Mitochondrial Targeting. (2016) (34)
- Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-induced colitis model. (2016) (33)
- Incorporation of polyinosine-polycytidylic acid enhances cytotoxic T cell activity and antitumor effects by octaarginine-modified liposomes encapsulating antigen, but not by octaarginine-modified antigen complex. (2013) (33)
- A Microbial Glycolipid Functions as a New Class of Target Antigen for Delayed-type Hypersensitivity* (2011) (33)
- Efficient cytoplasmic protein delivery by means of a multifunctional envelope-type nano device. (2007) (33)
- Multifunctional envelope-type nano device (MEND) for organelle targeting via a stepwise membrane fusion process. (2012) (33)
- Analysis of nonlinear tissue distribution of quinidine in rats by physiologically based pharmacokinetics (1985) (33)
- Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain (2014) (32)
- [Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid]. (2007) (32)
- The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ. (1994) (32)
- Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery. (2015) (32)
- Improving in vivo hepatic transfection activity by controlling intracellular trafficking: the function of GALA and maltotriose. (2011) (31)
- Increased SFHR gene correction efficiency with sense single‐stranded DNA (2005) (31)
- Optimization of siRNA delivery to target sites: issues and future directions (2018) (31)
- Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles. (2019) (31)
- Targeting Tumor Endothelial Cells with Nanoparticles (2019) (31)
- Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET (2011) (31)
- Effects of Thiopental on Regional Blood Flows in the Rat (1996) (31)
- Mitochondrial transgene expression via an artificial mitochondrial DNA vector in cells from a patient with a mitochondrial disease (2018) (31)
- Delivery of condensed DNA by liposomal non-viral gene delivery system into nucleus of dendritic cells. (2006) (30)
- An efficient PEGylated gene delivery system with improved targeting: Synergism between octaarginine and a fusogenic peptide. (2018) (30)
- Roles of specialized DNA polymerases in mutagenesis by 8-hydroxyguanine in human cells. (2010) (30)
- Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution. (2019) (30)
- Integration of nano drug-delivery system with cancer immunotherapy. (2017) (29)
- Accumulation of O‐GlcNAc‐Displaying CdTe Quantum Dots in Cells in the Presence of ATP (2007) (29)
- Neutralized Nanoparticle Composed of SS‐Cleavable and pH‐Activated Lipid‐Like Material as a Long‐Lasting and Liver‐Specific Gene Delivery System (2014) (29)
- Intranuclear DNA release is a determinant of transfection activity for a non-viral vector: biocleavable polyrotaxane as a supramolecularly dissociative condenser for efficient intranuclear DNA release. (2010) (29)
- Mutagenic effects of 2-hydroxy-dATP on replication in a HeLa extract: induction of substitution and deletion mutations. (2003) (29)
- Synthesis and evaluation of stearylated hyaluronic acid for the active delivery of liposomes to liver endothelial cells. (2011) (29)
- Mitochondrial-targeted DNA delivery using a DF-MITO-Porter, an innovative nano carrier with cytoplasmic and mitochondrial fusogenic envelopes (2012) (28)
- Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery. (2020) (28)
- Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress (2020) (28)
- Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs. (2004) (28)
- PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA. (2017) (28)
- Carnitine transport defect in fibroblasts of juvenile visceral steatosis (JVS) mouse. (1996) (27)
- The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ10 in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria. (2019) (27)
- Nano‐sized drug carriers: Extravasation, intratumoral distribution, and their modeling (2017) (27)
- Oligosaccharide‐Mediated Nuclear Transport of Nanoparticles (2008) (27)
- DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy. (2018) (27)
- Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme. (2005) (27)
- Octaarginine-modified liposomes enhance cross-presentation by promoting the C-terminal trimming of antigen peptide. (2014) (26)
- Lipid Nanoparticles for Cell-Specific in Vivo Targeted Delivery of Nucleic Acids. (2020) (26)
- A nanocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line. (2014) (26)
- Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes. (2012) (26)
- Development of a multifunctional envelope-type nano device and its application to nanomedicine. (2016) (26)
- NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. (2009) (26)
- A Multifunctional Lipid-based Nanodevice for the Highly-specific Co-delivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells. (2019) (26)
- Development of efficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure. (2005) (26)
- Immunoprotection against murine bladder carcinoma by octaarginine‐modified liposomes incorporating cell wall of Mycobacterium bovis bacillus Calmette‐Guérin (2009) (25)
- Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. (2011) (25)
- Neutralization of negative charges of siRNA results in improved safety and efficient gene silencing activity of lipid nanoparticles loaded with high levels of siRNA (2018) (25)
- Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their relationship. (2000) (25)
- Neutral biodegradable lipid-envelope-type nanoparticle using vitamin A-Scaffold for nuclear targeting of plasmid DNA. (2014) (25)
- Modality of tumor endothelial VEGFR2 silencing‐mediated improvement in intratumoral distribution of lipid nanoparticles (2017) (25)
- A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes. (2019) (25)
- pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes. (2017) (25)
- Interaction of Hemoglobin Vesicles, a Cellular-Type Artificial Oxygen Carrier, with Human Plasma: Effects on Coagulation, Kallikrein-Kinin, and Complement Systems (2006) (25)
- Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E/low density lipoprotein receptor and the N-acetyl-d-galactosamine/asialoglycoprotein receptor pathway. (2020) (25)
- Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo. (2021) (25)
- Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model (1993) (24)
- Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice. (2005) (24)
- New packaging method of mycobacterial cell wall using octaarginine-modified liposomes: enhanced uptake by and immunostimulatory activity of dendritic cells. (2007) (24)
- Validation of a Strategy for Cancer Therapy: Delivering Aminoglycoside Drugs to Mitochondria in HeLa Cells. (2016) (24)
- Modifying Antigen-Encapsulating Liposomes with KALA Facilitates MHC Class I Antigen Presentation and Enhances Anti-tumor Effects. (2017) (24)
- Major T Cell Response to a Mycolyl Glycolipid Is Mediated by CD1c Molecules in Rhesus Macaques (2012) (24)
- In vivo evaluation of the effect of the size and opsonization on the hepatic extraction of liposomes in rats: An application of Oldendorf method (1992) (23)
- Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II) (1992) (23)
- Validation of the use of an artificial mitochondrial reporter DNA vector containing a Cytomegalovirus promoter for mitochondrial transgene expression. (2017) (23)
- Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery. (2009) (23)
- Gene delivery systems: viral vs. non-viral vectors (2001) (23)
- The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter. (2020) (23)
- Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting (2018) (23)
- Advances in non-viral gene delivery: using multifunctional envelope-type nano-device (2008) (23)
- Innovative Technologies in Nanomedicines: From Passive Targeting to Active Targeting/From Controlled Pharmacokinetics to Controlled Intracellular Pharmacokinetics. (2017) (23)
- Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB (2020) (23)
- Intracellular fate of octaarginine-modified liposomes in polarized MDCK cells. (2010) (23)
- Kinetic modelling of liposome degradation in serum: Effect of size and concentration of liposomes in vitro (1994) (22)
- Species Difference in the Disposition of Liposomes Among Mice, Rats, and Rabbits: Allometric Relationship and Species Dependent Hepatic Uptake Mechanism (1996) (22)
- Enhanced autophagy induction via the mitochondrial delivery of methylated β-cyclodextrin-threaded polyrotaxanes using a MITO-Porter. (2019) (22)
- Construction of a multifunctional envelope-type nano device by a SUV*-fusion method. (2005) (22)
- A DNA microarray-based analysis of the host response to a nonviral gene carrier: a strategy for improving the immune response. (2011) (22)
- Validation of a mitochondrial RNA therapeutic strategy using fibroblasts from a Leigh syndrome patient with a mutation in the mitochondrial ND3 gene (2020) (22)
- Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells. (2013) (22)
- Mitochondrial delivery of an anticancer drug via systemic administration using a mitochondrial delivery system that inhibits the growth of drug-resistant cancer engrafted on mice. (2020) (22)
- Mitochondrial Delivery of Doxorubicin Using MITO-Porter Kills Drug-Resistant Renal Cancer Cells via Mitochondrial Toxicity. (2017) (21)
- Efficacy of DHMEQ, a NF-&kgr;B Inhibitor, in Islet Transplantation: I. HMGB1 Suppression by DHMEQ Prevents Early Islet Graft Damage (2013) (21)
- Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver. (1998) (21)
- Localization of exogenous DNA to mitochondria in skeletal muscle following hydrodynamic limb vein injection. (2013) (21)
- Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand (2014) (21)
- Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide. (2013) (21)
- Diverse substrate recognition and hydrolysis mechanisms of human NUDT5 (2011) (21)
- RNA interference-based silencing reveals the regulatory role of fatty acid-binding protein 4 in the production of IL-6 and vascular endothelial growth factor in 3T3-L1 adipocytes. (2012) (21)
- Characterization of a Nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates (2004) (21)
- "Programmed packaging" for gene delivery. (2014) (21)
- Effect of cationic liposomes in an in vitro transcription and translation system. (2002) (21)
- Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting. (2017) (20)
- Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells (2002) (20)
- Prediction of the plasma concentration time courses of various drugs in humans based on data from rats. (1985) (20)
- The location of the left-handedly curved DNA sequence affects exogenous DNA expression in vivo. (2007) (20)
- Efficient intradermal delivery of superoxide dismutase using a combination of liposomes and iontophoresis for protection against UV-induced skin damage. (2012) (20)
- Optical control of mitochondrial reductive reactions in living cells using an electron donor-acceptor linked molecule. (2017) (20)
- Size-dependent specific targeting and efficient gene silencing in peritoneal macrophages using a pH-sensitive cationic liposomal siRNA carrier. (2015) (20)
- Functional improvement of an IRQ-PEG-MEND for delivering genes to the lung. (2011) (20)
- Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake. (2011) (20)
- Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen. (2021) (20)
- A20 silencing by lipid envelope-type nanoparticles enhances the efficiency of lipopolysaccharide-activated dendritic cells. (2011) (20)
- Non‐Michaelis–Menten Type Hepatic Uptake of Liposomes in the Rat (1992) (19)
- Optimization of a siRNA Carrier Modified with a pH-Sensitive Cationic Lipid and a Cyclic RGD Peptide for Efficiently Targeting Tumor Endothelial Cells (2015) (19)
- Effects of silencing the RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without fusogenic companion GALA-cholesterol. (2014) (19)
- MITO-Porter for Mitochondrial Delivery and Mitochondrial Functional Analysis. (2016) (19)
- Ligand density at the surface of a nanoparticle and different uptake mechanism: two important factors for successful siRNA delivery to liver endothelial cells. (2014) (19)
- Anti-angiogenic nanotherapy via active targeting systems to tumors and adipose tissue vasculature. (2015) (19)
- Effect of the Compaction and the Size of DNA on the Nuclear Transfer Efficiency after Microinjection in Synchronized Cells (2015) (19)
- Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100 nm Particles. (2016) (19)
- Increased A:T-->C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: direct evidence for MutT involvement in the prevention of mutations by oxidized dGTP. (2004) (19)
- The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery. (2020) (18)
- Pretreatment of hepatocyte growth factor gene transfer mediated by octaarginine peptide-modified nanoparticles ameliorates LPS/D-galactosamine-induced hepatitis. (2012) (18)
- Effect of hydrophobic scaffold on the cellular uptake and gene transfection activities of DNA-encapsulating liposomal nanoparticles via intracerebroventricular administration. (2015) (18)
- An analysis of membrane fusion between mitochondrial double membranes and MITO-Porter, mitochondrial fusogenic vesicles. (2015) (18)
- A touch-and-go lipid wrapping technique in microfluidic channels for rapid fabrication of multifunctional envelope-type gene delivery nanodevices. (2011) (18)
- Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide. (2013) (18)
- The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig. (2001) (18)
- Influence of Endosomal Escape and Degradation of α-Galactosylceramide Loaded Liposomes on CD1d Antigen Presentation. (2015) (18)
- Application of BCG-CWS as a Systemic Adjuvant by Using Nanoparticulation Technology. (2018) (18)
- Targeted mitochondrial delivery of antisense RNA-containing nanoparticles by a MITO-Porter for safe and efficient mitochondrial gene silencing. (2019) (18)
- Advantages of ethanol dilution method for preparing GALA-modified liposomal siRNA carriers on the in vivo gene knockdown efficiency in pulmonary endothelium. (2014) (17)
- The nanomedicine rush: New strategies for unmet medical needs based on innovative nano DDS. (2020) (17)
- Mechanism responsible for the antitumor effect of BCG-CWS using the LEEL method in a mouse bladder cancer model. (2014) (17)
- Efficient and High-Speed Transduction of an Antibody into Living Cells Using a Multifunctional Nanocarrier System to Control Intracellular Trafficking. (2015) (17)
- Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug. (1996) (17)
- A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence. (2013) (17)
- Improved gene correction efficiency with a tailed duplex DNA fragment. (2008) (17)
- Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases. (2009) (17)
- On-chip fabrication of mutifunctional envelope-type nanodevices for gene delivery (2008) (17)
- Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100 nm Particles. (2016) (17)
- Sunflower‐Shaped Cyclodextrin‐Conjugated Poly(ε‐Lysine) Polyplex as a Controlled Intracellular Trafficking Device (2005) (17)
- In vivo studies on the role of complement in the clearance of liposomes in rats and guinea pigs. (1999) (16)
- A new peptide motif present in the protective antigen of anthrax toxin exerts its efficiency on the cellular uptake of liposomes and applications for a dual-ligand system. (2011) (16)
- The liposome‐incorporating cell wall skeleton of Mycobacterium bovis bacillus Calmette‐Guéin can directly enhance the susceptibility of cancer cells to lymphokine‐activated killer cells through up‐regulation of natural‐killer group 2, member D ligands (2011) (16)
- Complement dependent and independent liposome uptake by peritoneal macrophages: cholesterol content dependency. (1998) (16)
- Comparison between a multifunctional envelope-type nano device and lipoplex for delivery to the liver. (2010) (16)
- Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes (2014) (16)
- Hyaluronan-modified nanoparticles for tumor-targeting (2019) (15)
- Mutagenesis induced by oxidized DNA precursors: roles of Y family DNA polymerases in Escherichia coli. (2005) (15)
- Modifying Cationic Liposomes with Cholesteryl-PEG Prevents Their Aggregation in Human Urine and Enhances Cellular Uptake by Bladder Cancer Cells. (2017) (15)
- Neuronal injury induces microglial production of macrophage inflammatory protein‐1α in rat corticostriatal slice cultures (2012) (15)
- DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes. (2010) (15)
- Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short‐chain acyl‐carnitine level after l‐carnitine injection (1999) (15)
- Effective Therapy Using a Liposomal siRNA that Targets the Tumor Vasculature in a Model Murine Breast Cancer with Lung Metastasis (2018) (15)
- Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta. (2008) (15)
- An assessment of relative transcriptional availability from nonviral vectors. (2004) (15)
- Calpain 10 as a predictive gene for type 2 diabetes: evidence from a novel screening system using white blood cells of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. (2003) (15)
- UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides. (2007) (14)
- Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein. (2005) (14)
- Factors affecting SFHR gene correction efficiency with single-stranded DNA fragment. (2005) (14)
- Cytokine induction by a bacterial DNA-specific modified base. (2005) (14)
- Protecting liver sinusoidal endothelial cells suppresses apoptosis in acute liver damage (2016) (14)
- Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum. (1999) (14)
- The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds (2018) (13)
- A novel dual-targeted rosiglitazone-loaded nanoparticle for the prevention of diet-induced obesity via the browning of white adipose tissue. (2020) (13)
- Multifunctional Envelope-Type Nano Device: Evolution from Nonselective to Active Targeting System. (2015) (13)
- Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus. (2006) (13)
- Mono-cationic detergents play a critical role in the development of liposome-based gene vector via controlling its lamellarity (2014) (13)
- Construction of an aptamer modified liposomal system targeted to tumor endothelial cells. (2014) (13)
- Stearylated INF7 peptide enhances endosomal escape and gene expression of PEGylated nanoparticles both in vitro and in vivo. (2012) (13)
- Targeting the mitochondrial genome via a dual function MITO-Porter: evaluation of mtDNA levels and mitochondrial function. (2015) (13)
- Evolution of drug delivery system from viewpoint of controlled intracellular trafficking and selective tissue targeting toward future nanomedicine (2020) (13)
- A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver (2011) (13)
- Non-linear pharmacodynamics in the transfection efficiency of a non-viral gene delivery system. (2008) (13)
- Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization. (2019) (13)
- Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidylcholine-based liposomes. (2001) (13)
- An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid. (2013) (13)
- The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease's cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity. (2020) (13)
- Kinetic analysis of protein production after DNA transfection. (2005) (13)
- In vivo mutagenicities of damaged nucleotides produced by nitric oxide and ionizing radiation. (2005) (13)
- Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment. (2020) (13)
- Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity. (2020) (12)
- Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse (2016) (12)
- Improved stability of siRNA-loaded lipid nanoparticles prepared with a PEG-monoacyl fatty acid facilitates ligand-mediated siRNA delivery. (2020) (12)
- Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes. (2009) (12)
- Recent advances in the targeting of systemically administered non-viral gene delivery systems (2019) (12)
- Effects of benidipine hydrochloride (Coniel®), a new calcium antagonist, on the cardiac output, regional blood flow and vascular resistance in conscious, spontaneously hypertensive rats (1994) (12)
- Transcytosis-Targeting Peptide: A Conductor of Liposomal Nanoparticles through the Endothelial Cell Barrier. (2016) (12)
- Distinction Between the Depletion of Opsonins and the Saturation of Uptake in the Dose-Dependent Hepatic Uptake of Liposomes (1993) (12)
- Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme. (2006) (12)
- A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E‐scaffold lipid‐like material with the aid of an anti‐inflammatory drug (2018) (12)
- Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines. (2022) (12)
- Positive feedback system provides efficient and persistent transgene expression. (2010) (12)
- Topology of Surface Ligands on Liposomes: Characterization Based on the Terms, Incorporation Ratio, Surface Anchor Density, and Reaction Yield. (2016) (12)
- Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate. (1990) (12)
- Size-dependent release of carboxyfluorescein from cetylmannoside-modified liposomes in human plasma. (1996) (12)
- A DNA microarray-based analysis of immune-stimulatory and transcriptional responses of dendritic cells to KALA-modified nanoparticles. (2013) (12)
- Packaging of the Coenzyme Q10 into a Liposome for Mitochondrial Delivery and the Intracellular Observation in Patient Derived Mitochondrial Disease Cells. (2017) (12)
- Different mechanisms for nanoparticle formation between pDNA and siRNA using polyrotaxane as the polycation. (2012) (12)
- Evaluation of the nuclear delivery and intra-nuclear transcription of plasmid DNA condensed with micro (mu) and NLS-micro by cytoplasmic and nuclear microinjection: a comparative study with poly-L-lysine. (2006) (12)
- A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. (2019) (12)
- RNA aptamers for targeting mitochondria using a mitochondria-based SELEX method. (2014) (11)
- Kinetic modeling of liposome degradation in blood circulation (1993) (11)
- 2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract. (2007) (11)
- Vitamin E Scaffolds of pH-Responsive Lipid Nanoparticles as DNA Vaccines in Cancer and Protozoan Infection. (2020) (11)
- Correction of frameshift mutations with single-stranded and double-stranded DNA fragments prepared from phagemid/plasmid DNAs. (2005) (11)
- Silencing of exogenous DNA in cultured cells. (2006) (11)
- Action-at-a-distance mutagenesis induced by oxidized guanine in Werner syndrome protein-reduced human cells. (2015) (11)
- A nanocarrier for the mitochondrial delivery of nucleic acids to cardiomyocytes (2020) (11)
- Delivery of Nucleic Acids and Gene Delivery (2011) (11)
- GALA-Modified Lipid Nanoparticles for the Targeted Delivery of Plasmid DNA to the Lungs. (2021) (11)
- Kinetic modelling of liposome degradation in peritoneal macrophages (1995) (11)
- Comparative assessments of crucial factors for a functional ligand-targeted nanocarrier (2014) (11)
- Important amino acids in the phosphohydrolase module of Escherichia coli Orf135. (2004) (10)
- The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines. (2021) (10)
- Pharmacokinetic modeling of species-dependent enhanced bioavailability of trifluorothymidine by thymidine phosphorylase inhibitor. (2004) (10)
- Synergistic enhancement of cellular uptake with CD44-expressing malignant pleural mesothelioma by combining cationic liposome and hyaluronic acid-lipid conjugate. (2019) (10)
- Effect of the anchor in polyethylene glycol-lipids on the transfection activity of PEGylated cationic liposomes encapsulating DNA. (2012) (10)
- Multifunctional enveloped nanodevices (MENDs). (2014) (10)
- Temperature and pH sensitivity of a stabilized self-nanoemulsion formed using an ionizable lipid-like material via an oil-to-surfactant transition. (2017) (10)
- Development of small, homogeneous pDNA particles condensed with mono-cationic detergents and encapsulated in a multifunctional envelope-type nano device. (2008) (10)
- Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts (2021) (10)
- Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-hydroxy-2'- deoxyguanosine 5'-triphosphate). (2011) (10)
- A method for screening mitochondrial fusogenic envelopes for use in mitochondrial drug delivery. (2014) (10)
- Kinetic analysis of the interaction between liposomes and the complement system in rat serum: re-evaluation of size-dependency. (1998) (10)
- Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7,8-dihydroguanine (8-Hydroxyguanine) (2011) (10)
- A novel nonviral gene delivery system: multifunctional envelope-type nano device. (2010) (10)
- Non-linear pharmacokinetics of octaarginine-modified lipid nanoparticles: barriers from in vitro to in vivo. (2012) (10)
- In Vivo Inverse Correlation in the Activation of Natural Killer T Cells Through Dual-Signal Stimulation via a Combination of α-Galactosylceramide-Loaded Liposomes and Interleukin-12. (2016) (10)
- Targeted sequence alteration of a chromosomal locus in mouse liver. (2010) (10)
- DNA microarray analysis of type 2 diabetes-related genes co-regulated between white blood cells and livers of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. (2007) (9)
- Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein. (2006) (9)
- Transgene expression efficiency from plasmid DNA delivered as a complex with histone H3. (2010) (9)
- Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray. (2006) (9)
- Species difference in correlation between in vivo/in vitro liposome-complement interactions. (2001) (9)
- Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription. (2007) (9)
- Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP. (2008) (9)
- Preparation of envelope-type lipid nanoparticles containing gold nanorods for photothermal cancer therapy. (2017) (9)
- Size-Dependency of the Surface Ligand Density of Liposomes Prepared by Post-insertion. (2017) (9)
- Fabrication of Functionalized Double-Lamellar Multifunctional Envelope-Type Nanodevices Using a Microfluidic Chip with a Chaotic Mixer Array (2012) (9)
- On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device. (2022) (9)
- The Therapeutic Effects of R 8-Liposome-BCG-CWS on BBN-Induced Rat Urinary Bladder Carcinoma (2011) (9)
- Pharmacokinetics of targeting with liposomes. (2002) (9)
- Combined nano cancer immunotherapy based on immune status in a tumor microenvironment. (2022) (9)
- Gene Therapy for Hepatocellular Carcinoma: Highlighting the Journey from Theory to Clinical Applications (2020) (9)
- Effect of polyethyleneglycol spacer on the binding properties of nuclear localization signal-modified liposomes to isolated nucleus. (2009) (8)
- Strategies for fighting pandemic virus infections: Integration of virology and drug delivery (2022) (8)
- Effects of non-B DNA sequences on transgene expression. (2009) (8)
- Distribution of BCG-CWS loaded nanoparticles in the spleen after intravenous injection affects cytotoxic T lymphocyte activity. (2020) (8)
- pH-sensitive liposomes in nuclear targeting of macromolecules. (2003) (8)
- Effects of target sequence and sense versus anti-sense strands on gene correction with single-stranded DNA fragments. (2008) (8)
- Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion (2016) (8)
- Liver-Specific Silencing of Lipin1 Reduces Fat Mass as Well as Hepatic Triglyceride Biosynthesis in Mice. (2016) (8)
- Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques. (2013) (8)
- Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells (2021) (8)
- Cellular attachment and internalization of cationic liposomes containing mycobacterial cell wall (2008) (8)
- Development of a novel nanoparticle by dual modification with the pluripotential cell-penetrating peptide PepFect6 for cellular uptake, endosomal escape, and decondensation of an siRNA core complex. (2013) (8)
- Nonviral gene delivery. (2008) (8)
- Identification and Evaluation of the Minimum Unit of a KALA Peptide Required for Gene Delivery and Immune Activation. (2017) (8)
- Kinetic analysis of the positive inotropic action (PIA) of ouabain in isolated perfused rabbit heart. Slow onset of PIA and slow binding to Na+, K+-adenosine triphosphatase. (1988) (7)
- Condensation of Plasmid DNA Enhances Mitochondrial Association in Skeletal Muscle Following Hydrodynamic Limb Vein Injection (2014) (7)
- Advances in non-viral gene delivery: using multifunctional envelope-type nano-device. (2008) (7)
- Studies on the Mechanism of Uptake of Liposomes Using An Isolated Perfused Liver System (1996) (7)
- Reporter gene expression at single‐cell level characterized with real‐time RT‐PCR, chemiluminescence, fluorescence, and electrochemical imaging (2010) (7)
- Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production (2021) (7)
- Nonlinear tissue distribution of ouabain in rabbits. (1988) (7)
- Induction of various mutations during PCRs with manganese and 8-hydroxy-dGTP. (2007) (7)
- Correlation between transgen expression and plasmid DNA loss in mouse liver (2013) (7)
- Programmed Packaging: A New Drug Delivery System and its Application to Gene Therapy (2008) (7)
- The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition (2012) (7)
- The intracellular pharmacodynamics of siRNA is responsible for the low gene silencing activity of siRNA-loaded nanoparticles in dendritic cells. (2015) (7)
- Preparation of a Cyclic RGD: Modified Liposomal SiRNA Formulation for Use in Active Targeting to Tumor and Tumor Endothelial Cells. (2016) (7)
- Anatomy of plasmid DNAs with anti-silencing elements. (2014) (7)
- Transient Expression of Drosophila melanogaster Deoxynucleoside Kinase Gene Enhances Cytotoxicity of Nucleoside Analogs (2006) (7)
- Induction of transition and transversion mutations during random mutagenesis PCR by the addition of 2-hydroxy-dATP. (2004) (7)
- The effect of liposomal size on the targeted delivery of doxorubicin to Integrin alpha v beta 3-expressing tumor endothelial cells (2019) (6)
- Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells (2006) (6)
- Engineered ε-decalactone lipomers bypass the liver to selectively in vivo deliver mRNA to the lungs without targeting ligands. (2021) (6)
- Intravenous liposomal vaccine enhances CTL generation, but not until antigen presentation. (2022) (6)
- Correction: The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter. (2020) (6)
- Communication involvement of caveolin-1-mediated transcytosis in the intratumoral accumulation of liposomes. (2020) (6)
- Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells. (2010) (6)
- Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen (2020) (6)
- New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. (2015) (6)
- Increased A:T to C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: Direct evidence for MutT in the prevention of mutations by oxidized dGTP (2004) (6)
- In Vivo Transgene Expression in the Pancreas by the Intraductal Injection of Naked Plasmid DNA. (2018) (6)
- Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase. (2017) (6)
- Identification of a Nucleoporin358-Specific RNA Aptamer for Use as a Nucleus-Targeting Liposomal Delivery System. (2016) (6)
- Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect (2022) (5)
- Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations. (2021) (5)
- Validation of the mitochondrial delivery of vitamin B1 to enhance ATP production using SH-SY5Y cells, a model neuroblast. (2021) (5)
- Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system. (2011) (5)
- Significance of Binding to Na,K-ATPase in the Tissue Distribution of Ouabain in Guinea Pigs (1992) (5)
- PK-PD modeling of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes. (2009) (5)
- Effects of endogenous proteins and microRNA target sequence in a positive feedback system. (2012) (5)
- Dual imaging of mRNA and protein production: an investigation of the mechanism of heterogeneity in cationic lipid-mediated transgene expression. (2011) (5)
- mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy (2022) (5)
- Kinetic Modeling of Ouabain Tissue Distribution Based on Slow and Saturable Binding to Na,K-ATPase (1992) (5)
- Efficient Packaging of Plasmid DNA Using a pH Sensitive Cationic Lipid for Delivery to Hepatocytes. (2015) (5)
- Effect of methylated adenine in plasmid DNA on transgene expression in mice. (2005) (5)
- An effective in vivo mitochondria-targeting nanocarrier combined with a π-extended porphyrin-type photosensitizer (2021) (5)
- CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system. (2012) (4)
- Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex (2016) (4)
- [Development of an efficient short interference RNA (siRNA) delivery system with a new pH-sensitive cationic lipid]. (2012) (4)
- Antiangiogenic nanotherapy for the control of obesity. (2013) (4)
- Cytotoxic effect of Drosophila deoxynucleoside kinase gene on replicating plasmid in HeLa cells. (2010) (4)
- The Screening of RNA Aptamers Specific for Carbonic Anhydrase I Using the Systematic Evolution of Ligands by an Exponential Enrichment Method (SELEX) (2014) (4)
- Failure of active targeting by a cholesterol-anchored ligand and improvement by altering the lipid composition to prevent ligand desorption. (2018) (4)
- [MITO-Porter; a cutting-edge technology for mitochondrial gene therapy]. (2012) (4)
- New Design Strategies for Controlling the Rate of Hydrophobic Drug Release from Nanoemulsions in Blood Circulation. (2020) (4)
- Tri-membrane nanoparticles produced by combining liposome fusion and a novel patchwork of bicelles to overcome endosomal and nuclear membrane barriers to cargo delivery. (2016) (4)
- Effects of repeated clarithromycin administration on the pharmacokinetic properties of pindolol in rats. (1998) (4)
- Topology of octaarginines (R8) or IRQ ligand on liposomes affects the contribution of macropinocytosis- and caveolae-mediated cellular uptake (2011) (4)
- Kinetic analysis of the dose-dependent hepatic handling of 1-anilino-8-naphthalene sulfonate in rats (1990) (4)
- Investigation of siRNA Nanoparticle Formation Using Mono-Cationic Detergents and Its Use in Gene Silencing in Human HeLa Cells (2013) (4)
- [Targeting mitochondria: innovation from mitochondrial drug delivery system (DDS) to mitochondrial medicine]. (2012) (3)
- Effects of carriers on transgene expression from plasmids containing a DNA sequence with high histone affinity. (2009) (3)
- 518. Mechanism of Difference in the Transcription Activity of Nucleus-Delivered Transgene Introduced by Adenovirus and Lipoplex (2006) (3)
- Kinetic study on the optimization of tumor delivery of antitumor agents by liposomes: Simulation study based on the physiological modeling. (1997) (3)
- Liposome Microencapsulation for the Surface Modification and Improved Entrapment of Cytochrome c for Targeted Delivery (2018) (3)
- Base excision repair system suppresses mutagenesis caused by 8-hydroxy-dGTP in Escherichia coli. (2007) (3)
- No effect of age on the dose requirement of thiopental in the rat (1997) (3)
- [Development of various multifunctional envelope-type nano device MEND based on novel assembly technologies]. (2008) (3)
- ミトコンドリア標的型Drug Delivery System (DDS) が拓くミトコンドリア創薬への道 (2012) (3)
- Development of a Novel Systemic Gene Delivery System for Cancer Therapy with a Tumor‐Specific Cleavable PEG‐Lipid (2008) (3)
- 746. Evaluation of Nuclear Transfer and Transcription of Plasmid DNA Condensed with Protamine (2005) (3)
- Roles of specialized DNA polymerases in mutagenesis by oxidized guanine. (2009) (3)
- Enhanced transgene expression from chromatinized plasmid DNA in mouse liver. (2013) (3)
- Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease. (2022) (3)
- Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell‐specific liposomal siRNA delivery system (2022) (3)
- Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device. (2005) (3)
- A Multifunctional Envelope-Type Nano Device Containing a pH-Sensitive Cationic Lipid for Efficient Delivery of Short Interfering RNA to Hepatocytes In Vivo. (2016) (3)
- Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats: I (1992) (3)
- Infusion rate-dependent positive inotropic action of ouabain in rabbits. (1987) (3)
- 340. Cellular Uptake and Subsequent Intracellular of R8-Liposomes Introduced at Low Temperature (2006) (3)
- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of Mitochondrial Gene Expression (2018) (3)
- Two Modes of Toxicity of Lipid Nanoparticles Containing a pH-Sensitive Cationic Lipid on Human A375 and A375-SM Melanoma Cell Lines (2019) (2)
- Critical parameters dictating efficiency of membrane‐mediated drug transfer using nanoparticles (2018) (2)
- Innovative cancer nanomedicine based on immunology, gene editing, intracellular trafficking control. (2022) (2)
- Mutagenesis by damaged deoxyribonucleotides and its prevention by MutT-type hydrolyzing enzymes. (2004) (2)
- Perspective on the new strategy of intracellular delivery of macromolecules with carrier. (1999) (2)
- Correlation between the Phosphohydrolase Activity of the Escherichia coli Orf135 (NudG) Protein and Mutation Suppression (2007) (2)
- Scalable preparation of poly(ethylene glycol)-grafted siRNA-loaded lipid nanoparticles using a commercially available fluidic device and tangential flow filtration (2017) (2)
- The use of cardiac progenitor cells for transplantation in congenital heart disease and an innovative strategy for activating mitochondrial function in such cells. (2018) (2)
- 1H, 13C and 15N NMR assignments of the Escherichia coli Orf135 protein (2012) (2)
- Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver. (2013) (2)
- Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis (2022) (2)
- mRNA-Loaded Lipid Nanoparticles Targeting Immune Cells in the Spleen for Use as Cancer Vaccines (2022) (2)
- siRNA delivery by multifunctional envelope-type nano device (MEND) (2010) (2)
- FoxO 6 in glucose metabolism FoxO 6 Depletion Attenuates Hepatic Gluconeogenesis and Protects Against Fat-Induced Glucose Disorder in Mice (2015) (2)
- Pharmacokinetic Studies on the Drug Delivery System Using Liposomes (1995) (2)
- Conversion of nucleotide sequence with single-stranded DNA fragment prepared from phagemid DNA. (2005) (2)
- Correction of frameshift mutations with tailed duplex DNAs. (2011) (2)
- Non-invasive gene delivery across the blood-brain barrier: present and future perspectives (2021) (2)
- Interval- and cycle-dependent combined effect of STING agonist loaded lipid nanoparticles and a PD-1 antibody. (2022) (2)
- Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA (2022) (2)
- High throughput purification device for gene delivery multifunctional envelope-type nanodevice (2012) (1)
- Design of Smart Nano Device for Intracellular Targeting (2011) (1)
- In vivo selection of active deoxyribonucleoside kinase by a mutagenic nucleoside analog. (2016) (1)
- Advanced drug delivery 2020 - Parts 1,2 and 3. (2020) (1)
- Pharmacokinetics of Gene Delivery in Cells (2005) (1)
- Validation of a therapeutic strategy involving the mitochondrial delivery of thiamine pyrophosphate using brain damage induced mouse model (2022) (1)
- Instructions for use Title Effects of insulator cHS 4 on transgene expression from plasmid DNA in a positive feedback system (2018) (1)
- Recent advancements of DDS research in Japan. Editorial. (2011) (1)
- P2537Cardiac progenitor cells with resveratrol delivered into mitochondria can ameliorate survival of doxorubicin-induced cardiomyopathy mouse via mitochondrial activation of damaged myocardium (2017) (1)
- The effect of liposoinal dose on the intracellular fate of liposoines in rats in vivo. (1996) (1)
- Targeting the Mitochondrial Genome Via a MITO-Porter : Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function. (2021) (1)
- [Development of multifunctional envelope type artificial viral-like gene delivery system]. (2007) (1)
- Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis. (2022) (1)
- Microfluidic approach for production of lipid nanoparticles-based nano medicine (2015) (1)
- Prediction of serum concentration time course of quinidine in human using a physiologically based pharmacokinetic model developed from the rat. (1986) (1)
- A complicated interpretation of a therapeutic effect with humanized mice using a novel peptide platform (2017) (1)
- 529. Development of Novel Systemic Gene Delivery System for Cancer Therapy with Tumor-Specifically Cleavable PEG-Lipid (2006) (1)
- Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract (2006) (1)
- Efficient Intracellular Delivery of Nucleic Acids using Cell-Penetrating Peptides (CPP) (2011) (1)
- Recent advances in delivering RNA-based therapeutics to mitochondria (2022) (1)
- EPR effect and development of new strategy for nanoparticle delivery via remodeling tumor microenvironment based on tumor vasculature targeting (2018) (1)
- [Development of non-viral vector based on the quantitative comparison of intracellular trafficking with viral vector]. (2006) (1)
- Retrograde Axonal Transport of Liposomes from Peripheral Tissue to Spinal Cord and DRGs by Optimized Phospholipid and CTB Modification (2022) (1)
- Quantitative analysis of the stability of liposomes in blood in vivo (1991) (1)
- Fine‐tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects (2022) (1)
- Non-Viral Gene Therapy in Trabecular Meshwork Cells to Prevent Fibrosis in Minimally Invasive Glaucoma Surgery (2022) (1)
- [Envelope-type nano device for gene delivery]. (2006) (0)
- Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery Concept and Application for Nanomedicine (2012) (0)
- 1H, 13C and 15N NMR assignments of the Escherichia coli Orf135 protein (2011) (0)
- Instructions for use Title Hepatic Monoacylglycerol O-acyltransferase 1 as a PromisingTherapeutic Target for Steatosis , Obesity , and Type 2 Diabetes (2017) (0)
- Lung‐Targeted Rnai Therapeutics: Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer (Adv. Funct. Mater. 18/2019) (2019) (0)
- A Multifunctional Envelope-Type Nano Device for Cancer Therapy (2019) (0)
- A more excellent construction method of a multi functional envelope-type nano device on microdevice for gene therapy (2007) (0)
- Delivering mRNA to a human NK cell line, NK-92 cells, by lipid nanoparticles. (2023) (0)
- Optimization of long circulating liposomes for antitumor egents. (2000) (0)
- Researches-Novel Lipidated Sorbitol-Based Molecular Transporters for Non Viral Gene Delivery (2017) (0)
- Production of small nano-sized particles by complex formation between polycations and linearized plasmid DNA at a low pH. (2013) (0)
- 376. Various Aspects of the Single-Stranded DNA Fragment-Mediated Gene Correction (2005) (0)
- Non-viral Gene Delivery (2021) (0)
- A new microdevice to rapidly constract Multifunctional Envelope-type Nanodevice for gene therapy (2009) (0)
- Development of an innovative drug delivery system targeted to adipose vessel utilizing novel nucleic acid aptamer for control of obesity (2018) (0)
- The nanoparticulation of α-galactosylceramide by octaarginine-modified liposome enhances α-galactosylceramide mediated antitumor effects in an experimental lung metastasis model (2013) (0)
- Instructions for use Title Effective Therapy Using a Liposomal siRNA that Targets the Tumor Vasculature in a Model Murine Breast (2019) (0)
- Issue Information (2014) (0)
- Oxidized DNA and DNA precursors : genomic instability induced and its defense system (2002) (0)
- Mechanistic Study of Membrane Transport of Octaarginine, Stearylated-octaarginine and Octaarginine-modified Liposomes (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜 講演要旨集) (2003) (0)
- O‐11: Dual function of RIG‐I RNA helicase as an innate sensor and as a direct antiviral effector during hepatitis B virus infection (2015) (0)
- 592. A Multifunctional Envelope-Type Nano Device for the Novel Gene Delivery of siRNA Plasmids: Optimization of Condensing Polycations (2005) (0)
- MITO-Porter, Multifunctional Envelope-Type Nano Device for Mitochondrial Delivery toward Innovative Nano Medicine (2017) (0)
- High throughput purification devices for in vivo applications of gene-delivery multifunctional envelope-type nanodevices (2013) (0)
- 581. Development of a Non-Viral DNA Vector Multifunctional Envelop-type Nano Device Modified with Octaarginine Peptide (2005) (0)
- Anti-angiogenic Therapy by Targeting the Tumor Vasculature with Liposomes (2016) (0)
- The Complement- but not Mannose Receptor-mediated Phagocytosis is Involved in the Hepatic Uptake of Cetylmannoside-modified Liposomes In Situ (2003) (0)
- Instructions for use Title Noninvasive and persistent transfollicular drug delivery systemusing a combination of liposomes and iontophoresis (2017) (0)
- Substrate recognition by the human MTH1 protein. (2002) (0)
- Gene Delivery Using Lipid-like Material Composed of Fat Soluble Vitamin (2013) (0)
- A targeted liposomal delivery system to liver endothelial cell based on a new peptide motif present in the Apo B100 sequence (2013) (0)
- 566. Silencing of Plasmid DNA after Hydrodynamics-Based Transfection in Mice (2005) (0)
- Effects of supramolecular structure of cationic-polyrotaxanes on pDNA compaction (2006) (0)
- Mass production system for RNA-loaded lipid nanoparticles using piling up microfluidic devices (2023) (0)
- 748. Quantitative Comparison of the Intracellular Trafficking and Expression Pattern of the Exogenous Genes between the Adenovirus and Artificial Vector (2005) (0)
- Targeting the Via a : Evaluation of mtDNA and mtRNA Levels and Mitochondrial (2021) (0)
- Drug Delivery Systems: Mitochondria-Targeted (2015) (0)
- Microenvironmental Changes in Mediastinal Fat-associated Lymphoid Clusters and Lungs in Early and Late Stages of Metastatic Lung Cancer Induction (2023) (0)
- COMPLEMENT-MEDIATED HEPATIC UPTAKE OF MANNOSIDE-MODIFIED LIPOSOMES (1994) (0)
- Effect of a Nanoparticle-Based Multivalent Targeted Proapoptotic Peptide on Obesity (2013) (0)
- Controlled Intracellular Trafficking Using Plasma and Endosomal Membrane Interactive Peptides. (2003) (0)
- 68. Development of a Novel Non-Viral DNA Vaccine-Delivering Gene into the Nucleus of Dendritic Cells (2005) (0)
- [OPINION] Species Barrier: From PK to DDS (2017) (0)
- 1SA2-09 Quantitative analysis of transfection efficiency between viral and non-viral vector : From cellular uptake to transcription/translation(1SA2 BSJ&ABA Joint Symposium, "Prion and Virus Infections",The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
- Development of Various Multifunctional Envelope-Type Nano Device MEND Based on Novel Assembly Technologies (2008) (0)
- KINETIC ANALYSIS OF THE UPTAKE PROCESS OF LIPOSOMES BY RES (1991) (0)
- Tokuda Akihiro Tomida Shinya Toyokuni Hitoshi Tsuda Shoichiro Tsugane Tatsuhiko Tsunoda Heiichiro Udono Koji Ueda Yoshimasa Uehara Hiroo Ueno Kazuo Umezawa Toshikazu Ushijima Toshihiko Wakabayashi Kenji Wakai Tetsuro Watabe (2016) (0)
- Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying Nanodelivery Systems (2010) (0)
- Instructions for use Title Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3 T 3L 1 adipocytes (2017) (0)
- 577. Distribution, Time Course, In-Vivo Imaging, Expression and Inflammatory Response after Non-Viral Gene Delivery to Rat and Primate CNS (2005) (0)
- Incorporation of the nuclear localization signal (NLS) peptide-albumin conjugate to macrophages using pH-sensitive liposomes (1999) (0)
- オクタアルギニン,オクタアルギニン-ステアリル酸塩及びオクタアルギニン修飾リポソームの膜輸送メカニズムの研究 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター (2003) (0)
- Viral Gene Delivery (2021) (0)
- Lipid membrane structure for intracellular delivery of siRNA (2015) (0)
- Multifunctional envelope type nano device for non-viral gene delivery: concept and application for nanomedicine. (2008) (0)
- Abstract P4-04-08: A Potential non-viral vector to transfect dendritic cell and thereby MHC-Class I antigen presentation might be a potential use in carcinoma (2012) (0)
- QUANTITATIVE COMPARISON OF INTRACELLULAR TRAFFICKING BETWEEN ARTIFICIAL AND VIRAL VECTOR: MECHANISM UNDERLYING THE DIFFERENCE IN DOMINANT RATE-LIMITING PROCESS (2006) (0)
- Development of MT1-MMP-targeted immunoliposome for the cancer therapy by inhibition of angiogenesis (2006) (0)
- In vitro evaluation of cationic polyrotaxanes as gene carrier (2006) (0)
- Mutations induced by 2-hydroxy-dATP during in vitro replication with a HeLa extract. (2003) (0)
- Editorial: Advanced Liposome Research. (2020) (0)
- Preparation of Poly[lactic-co-glycolic] Acid Nanospheres and Its Role in Hepatoma Cells. (2021) (0)
- diabetes in combination with DNA microarray and in vivo siRNA delivery (2013) (0)
- Nucleic Acids for Gene Therapy (2021) (0)
- Abstract B64: A Lys-Ala-Leu-Ala (KALA) repeated peptide modification in DNA nanoparticles of DOPE/CHEMS, follows GPCR mediated transgene expression in dendritic cell (2015) (0)
- 1007. Development of Nuclear Targeting System of Plasmid DNA; Impact of Sugar Display on the Surface of Lipid Envelope (2006) (0)
- An approach to mitochondrial gene silencing by the mitochondrial delivery of antisense RNA (2013) (0)
- THE GALA PEPTIDE: MULTIPLE ROLES IN DRUG AND GENE DELIVERY (2020) (0)
- Abstract 3886: Development of a new DNA aptamer against primary cultured tumor endothelial cells by a cell-based SELEX method to discover a new drug delivery system (2012) (0)
- Utilization efficiency of the oxidized purine nucleotide analogs by DNA polymerase eta. (2003) (0)
- 578. Quantitative Evaluation of the Relationship between Efficiency of Nuclear Transfer of Plasmid DNA and Trans-Gene Expression in Individual Cell: Consideration of Mechanism Underlying in the Heterogeneity of the Trans-Gene Expression Via Artificial Vector (2005) (0)
- Validation of a mitochondrial RNA therapeutic strategy using fibroblasts from a Leigh syndrome patient with a mutation in the mitochondrial ND3 gene (2020) (0)
- Procédé de production de microcapsules (2007) (0)
- KINETIC ANALYSIS OF LIPOSOME UPTAKE BY RES IN COMPARISON TO THEIR DEGRADATION IN BLOOD AND RES (1993) (0)
- TARGETING DESIGN TO THE LUNG AND PULMONARY INTRACELLULAR STRUCTURE OF ENDOGENOUS GENE BY IRQ MODIFIED NANO CARRIER (2011) (0)
- BPB Reports (2019) (0)
- Newly Designed DNA Fragments for Gene Correction (2005) (0)
- Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides (2013) (0)
- 528. Significant Silencing Effect of a Multifunctional Envelope-Type Nano Device Encapsulating Antisense Oligodeoxynucleotide and Double-Stranded siRNA (2006) (0)
- [OPINION]Toward Clinical Translation of Gene/Nucleic Acid Nanomedicine (2019) (0)
- Neutralized lipid envelope-type nanoparticle encapsulating pDNA as a liver-specific and long-lasting gene expression (2013) (0)
- in Rhesus Macaques Glycolipid Is Mediated by CD1c Molecules Major T Cell Response to a Mycolyl (2014) (0)
- Microfluidic device to construct multifunctional envelope-type nanodevice for gene therapy (2008) (0)
- INNOVATIVE TECHNOLOGY FOR IN VIVO MITOCHONDRIAL GENE DELIVERY USING HYDRODYNAMIC LIMB VEIN INJECTION (2014) (0)
- Is delivery promotion in the nucleus of the gene by the nuclear localization signal possible (1999) (0)
- Octaarginine-mediated stimulation of clathrin-independent endocytic uptake leading to enhanced gene expression through avoiding lysosomal degradation (2005) (0)
- Development of multifunctional envelope-type nano-device (MEND) based on the regulation of intracellular trafficking (2007) (0)
- Development of a pH-sensitive multifunctional envelope-type nano device ( MEND ) as an efficient nucleic acids delivery system (2013) (0)
- triphosphate ) by human MTH 1 , MTH 2 , and NUDT 5 (2017) (0)
- Development of a Mitochondrial Targeting Lipid Nanoparticle Encapsulating Berberine (2023) (0)
- Molecular design and drug delivery of genetic drugs (2001) (0)
- Simulation study on the optimum conditions of liposomes for antitumor effect of doxorubicin and its experimental validation (1997) (0)
- Suppression of Short Tract Gene Conversion in Episomal DNA by p53 Reduction (2014) (0)
- Abstract C66: A novel technique to quantify condensation/decondensation status in the nuclear subdomains by QD‐FRET (2009) (0)
- Significance of Targeting Mitochondria and the Current Status of Mitochondrial DDS Development (2016) (0)
- On-chip construction of a multifunctional envelope-type nano device for a non-viral gene delivery system (2006) (0)
- Instructions for use Title Non-linear pharmacokinetics of octaarginine-modified lipid nanoparticles : Barriers from in vitro to invivo (2017) (0)
- Simulation study on the prediction of optimum release rate of antitumor drugs from liposomes based on the physiological model with cell kill kinetic model (1996) (0)
- Development of Multifunctional Envelope-Type Artificial Viral-Like Gene Delivery System (2008) (0)
- The effect of plasmid DNA sequence on gene expression and polycation complex formation (2013) (0)
- An Improvement Delivery of siRNA by IRQ Ligand‐Modified Double Membranous Nano‐Carrier (2010) (0)
- Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system (2013) (0)
- On the mechanism of tissue-selective gene delivery by lipid nanoparticles. (2023) (0)
- Rational drug delivery system for DOX encapsulated in long circulating liposomes in mice with peritneal tumors. (1999) (0)
- Issue Information (2022) (0)
- The Effect of Cryoprotectants and Storage Conditions on the Transfection Efficiency, Stability and Safety of Lipid-Based Nanoparticles for mRNA and DNA Delivery. (2023) (0)
- Lipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing. (2023) (0)
- 587. Artificial Viral-Like Gene Delivery System Multifunctional Envelope-type Nano Device Equipped with Transferrin and a pH-Sensitive Fusogenic Peptide (2005) (0)
- Development of Non-Viral Vector Based on the Quantitative Comparison of Intracellular Trafficking with Viral Vector (2007) (0)
- Instructions for use Title Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirusand lipoplex (2017) (0)
- Title : A new adjuvant delivery system ' cyclic di-GMP / YSK 05 liposome ' for cancer immunotherapy (2018) (0)
- Modulation of Endosomal Escape of IRQ‐PEGylated Nano‐carrier (2011) (0)
- Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect (2022) (0)
- Mutagenic properties of oxidized GTP and ATP in in vitro transcription-reverse transcription. (2006) (0)
- RNA Delivery to Mitochondria. (2023) (0)
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What Schools Are Affiliated With Hideyoshi Harashima?
Hideyoshi Harashima is affiliated with the following schools:
