Hideyuki Saya
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Researcher ORCID ID = 0000-0001-6610-1902
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Molecular Biology
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Biochemistry
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Biology
Hideyuki Saya's Degrees
- PhD Molecular Biology University of Tokyo
- Masters Biochemistry University of Tokyo
- Bachelors Biology University of Tokyo
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(Suggest an Edit or Addition)Hideyuki Saya's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. (2011) (941)
- Aurora-A — A guardian of poles (2005) (691)
- Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. (2003) (665)
- Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells (2003) (639)
- Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence (2006) (476)
- Mechanism and biological significance of CD44 cleavage (2004) (377)
- Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway (2001) (376)
- Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells* (2003) (371)
- M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis (2009) (355)
- Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell (2012) (323)
- Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation (2004) (305)
- Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells (2008) (298)
- High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation. (1996) (295)
- Expression of CD44R1 adhesion molecule in colon carcinomas and metastases (1993) (278)
- CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration (1999) (273)
- Dependence of Paclitaxel Sensitivity on a Functional Spindle Assembly Checkpoint (2004) (260)
- Codon 72 polymorphism of the TP53 gene. (1990) (253)
- Evidence for p53-Mediated Modulation of Neuronal Viability (1996) (252)
- Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. (1994) (251)
- CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. (2003) (244)
- Autophosphorylation of a Newly Identified Site of Aurora-B Is Indispensable for Cytokinesis* (2004) (236)
- RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. (2005) (225)
- Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma (2015) (223)
- Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent (2018) (219)
- Association of the Myosin-binding Subunit of Myosin Phosphatase and Moesin: Dual Regulation of Moesin Phosphorylation by Rho-associated Kinase and Myosin Phosphatase (1998) (217)
- Therapeutic strategies targeting cancer stem cells (2015) (215)
- Methylation-Mediated Transcriptional Silencing in Euchromatin by Methyl-CpG Binding Protein MBD1 Isoforms (1999) (212)
- Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells (2002) (209)
- Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells (2012) (207)
- Chfr is required for tumor suppression and Aurora A regulation (2005) (197)
- Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. (2012) (183)
- CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma. (2012) (178)
- cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) (177)
- Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells. (2012) (175)
- Zyxin, a Regulator of Actin Filament Assembly, Targets the Mitotic Apparatus by Interacting with H-Warts/Lats1 Tumor Suppressor (2000) (172)
- Roles of Rho-associated Kinase in Cytokinesis; Mutations in Rho-associated Kinase Phosphorylation Sites Impair Cytokinetic Segregation of Glial Filaments (1998) (171)
- Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents (2004) (164)
- The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future? (2007) (163)
- Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors. (2002) (163)
- Mechanism of Transcriptional Regulation by Methyl-CpG Binding Protein MBD1 (2000) (161)
- Hyaluronan Oligosaccharides Induce CD44 Cleavage and Promote Cell Migration in CD44-expressing Tumor Cells* (2003) (157)
- LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development (2016) (154)
- DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells. (2012) (154)
- Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models (2004) (152)
- Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. (2008) (150)
- Activation of Cdh1‐dependent APC is required for G1 cell cycle arrest and DNA damage‐induced G2 checkpoint in vertebrate cells (2001) (149)
- Tumor Necrosis Factor-α Regulates Transforming Growth Factor-β-dependent Epithelial-Mesenchymal Transition by Promoting Hyaluronan-CD44-Moesin Interaction* (2009) (145)
- Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria* (2005) (144)
- Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation (2014) (143)
- NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 Recruitment (2006) (143)
- c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis (2010) (143)
- Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity (1993) (140)
- Down‐regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1‐dependent DNA‐damage checkpoint signals contributes to cell cycle arrest at G1/S transition (2004) (140)
- Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. (2017) (139)
- Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44 (2003) (136)
- Real-time in vivo imaging of p16Ink4a reveals cross talk with p53 (2009) (132)
- Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contacts (1999) (131)
- CD44+ slow‐cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis (2010) (129)
- Proteomic analysis of human brain identifies α‐enolase as a novel autoantigen in Hashimoto's encephalopathy (2002) (129)
- xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma. (2013) (128)
- Germline p53 gene mutations in subsets of glioma patients. (1994) (127)
- Concise Review: Stem Cells and Epithelial‐Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets (2016) (123)
- Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche. (2016) (122)
- Differential expression of two types of the neurofibromatosis type 1 (NF1) gene transcripts related to neuronal differentiation. (1991) (122)
- Complexity of cancer stem cells (2013) (120)
- p53 Regulates Toll-Like Receptor 3 Expression and Function in Human Epithelial Cell Lines (2008) (117)
- Multiple Roles of Vertebrate REV Genes in DNA Repair and Recombination (2005) (117)
- Cooperation of HECT-domain Ubiquitin Ligase hHYD and DNA Topoisomerase II-binding Protein for DNA Damage Response* (2002) (116)
- Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer (1998) (114)
- The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas (1998) (111)
- Regulated CD44 Cleavage under the Control of Protein Kinase C, Calcium Influx, and the Rho Family of Small G Proteins* (1999) (111)
- An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment (2018) (110)
- IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells (2013) (110)
- Human ubiquitin‐protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin‐conjugating enzymes (1998) (109)
- TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells (2014) (108)
- The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association (1999) (105)
- Neuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A. (1988) (101)
- Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells. (1995) (100)
- A human homolog of Drosophila warts tumor suppressor, h‐warts, localized to mitotic apparatus and specifically phosphorylated during mitosis (1999) (99)
- Neurofibromatosis Type I Tumor Suppressor Neurofibromin Regulates Neuronal Differentiation via Its GTPase-activating Protein Function toward Ras* (2003) (96)
- Expression of TNF‐α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas (2015) (95)
- A novel human nucleoside diphosphate (NDP) kinase, Nm23‐H6, localizes in mitochondria and affects cytokinesis (2000) (93)
- K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. (2009) (91)
- MCAF Mediates MBD1-Dependent Transcriptional Repression (2003) (90)
- Influence of p53 mutations on prognosis of patients with glioblastoma (2002) (90)
- Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell–cell fusion (2012) (90)
- Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function (2004) (89)
- Prospects for new lung cancer treatments that target EMT signaling (2018) (86)
- IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma (2019) (85)
- Neurofibromatosis Type 1 (NF1) Tumor Suppressor, Neurofibromin, Regulates the Neuronal Differentiation of PC12 Cells via Its Associating Protein, CRMP-2* (2008) (83)
- RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI3 Kinase/Akt Signaling Pathways (2012) (82)
- Effectiveness of plasma treatment on gastric cancer cells (2015) (82)
- Ras Oncoprotein Induces CD44 Cleavage through Phosphoinositide 3-OH Kinase and the Rho Family of Small G Proteins* (2000) (80)
- Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells. (2011) (80)
- Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. (2003) (80)
- Identification of the cis‐acting region in the NF2 gene promoter as a potential target for mutation and methylation‐dependent silencing in schwannoma (2001) (79)
- Interaction of NE-dlg/SAP102, a Neuronal and Endocrine Tissue-specific Membrane-associated Guanylate Kinase Protein, with Calmodulin and PSD-95/SAP90 (1999) (77)
- Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas (1994) (77)
- Angiographic classification of aneurysms of the horizontal segment of the anterior cerebral artery. (1985) (75)
- The Aryl Hydrocarbon Receptor Nuclear Transporter Is Modulated by the SUMO-1 Conjugation System* (2002) (72)
- Molecular mechanisms regulating dissociation of cell–cell junction of epithelial cells by oxidative stress (2009) (72)
- Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation. (2014) (72)
- The Neurofibromatosis Type 1 Gene Product Neurofibromin Enhances Cell Motility by Regulating Actin Filament Dynamics via the Rho-ROCK-LIMK2-Cofilin Pathway* (2005) (72)
- Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells (2011) (71)
- Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region (1998) (70)
- Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor‐negative breast cancer (2012) (70)
- Tumour resistance in induced pluripotent stem cells derived from naked mole-rats (2016) (69)
- Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival. (2001) (69)
- Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein (1997) (68)
- The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-). (2016) (68)
- Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin (2009) (68)
- Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer* (2012) (68)
- Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation. (2014) (67)
- Evidence that HLA class II‐restricted human CD4+ T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms (1998) (67)
- Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205) (2017) (67)
- HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint (2008) (67)
- Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and bladder cancer using the polymerase chain reaction (1991) (66)
- Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP‐dependent protein kinase (1996) (66)
- IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress. (2014) (66)
- Functional role of CD44v‐xCT system in the development of spasmolytic polypeptide‐expressing metaplasia (2013) (66)
- Molecular detection of cancer cells by competitive reverse transcription-polymerase chain reaction analysis of specific CD44 variant RNAs. (1998) (65)
- Molecular biology of glioma. (2012) (65)
- Identification of a novel human homolog of the Drosophila dlg, P‐dlg, specifically expressed in the gland tissues and interacting with p55 (1998) (64)
- Phosphorylation of neurofibromin by cAMP‐dependent protein kinase is regulated via a cellular association of N G,N G‐dimethylarginine dimethylaminohydrolase (2001) (64)
- Myristoylated alanine‐rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C‐dependent pathway (2010) (63)
- Breast cancer stem cells (2010) (63)
- PKA phosphorylation and 14‐3‐3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin (2004) (63)
- Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals (2007) (62)
- Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis (2013) (61)
- T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease (2018) (60)
- Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx (2000) (60)
- Usefulness of sampling with cotton swab for PCR-diagnosis of cutaneous leishmaniasis in the New World. (2002) (60)
- Tumor necrosis factor-α (TNF-α) stimulates the epithelial–mesenchymal transition regulator Snail in cholangiocarcinoma (2012) (60)
- A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes (1999) (58)
- Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival (2018) (58)
- Energy Management by Enhanced Glycolysis in G1-phase in Human Colon Cancer Cells In Vitro and In Vivo (2013) (57)
- Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. (2002) (57)
- Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines (2001) (57)
- Significant Correlation of Nitric Oxide Synthase Activity and p53 Gene Mutation in Stage I Lung Adenocarcinoma (1998) (56)
- Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells (2016) (56)
- Characteristics of glioma stem cells (2013) (56)
- Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity (2016) (56)
- Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model (2009) (56)
- The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer (2017) (56)
- Detection of cellular proteins that interact with the NF2 tumor suppressor gene product. (1994) (55)
- PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma (2011) (55)
- PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties. (2010) (54)
- Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality (2017) (54)
- Immunocytochemical detection of p53 in human gliomas. (1991) (54)
- Serum response factor is modulated by the SUMO-1 conjugation system. (2003) (54)
- Effect of herbimycin A on growth and pp60c-src activity in human colon tumor cell lines. (1991) (53)
- Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice (2008) (52)
- Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression (2015) (51)
- Molecular and cellular mechanisms underlying brain metastasis of breast cancer (2020) (51)
- MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53. (2016) (51)
- TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state (2014) (51)
- Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme. (2002) (50)
- Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells. (2011) (49)
- Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model (2018) (49)
- Rapid identification of Leishmania species from formalin-fixed biopsy samples by polymorphism-specific polymerase chain reaction. (1998) (48)
- Suppression of centrosome amplification after DNA damage depends on p27 accumulation. (2006) (48)
- WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis (2002) (48)
- CD44 variant‐dependent redox status regulation in liver fluke‐associated cholangiocarcinoma: A target for cholangiocarcinoma treatment (2016) (48)
- Novel variants of CD44 arising from alternative splicing: Changes in the CD44 alternative splicing pattern of MCF‐7 breast carcinoma cells treated with hyaluronidase (1993) (47)
- Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells (2018) (47)
- LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression (2012) (47)
- In vivo assessment of cancerous tumors using boron doped diamond microelectrode (2012) (46)
- Loss of E-cadherin promotes migration and invasion of cholangiocarcinoma cells and serves as a potential marker of metastasis (2014) (46)
- BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells (2009) (46)
- Expression profiles of carcinosarcoma of the uterine corpus—are these similar to carcinoma or sarcoma? (2012) (46)
- The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death (2005) (46)
- Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model. (2014) (45)
- Activation of m-Calpain Is Required for Chromosome Alignment on the Metaphase Plate during Mitosis* (2004) (45)
- Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain (1998) (44)
- A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain. (2001) (44)
- Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. (2007) (44)
- Over‐expression of Aurora‐A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1 (2005) (44)
- CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas. (1995) (44)
- Proteome profiling reveals gender differences in the composition of human serum (2010) (44)
- Tight‐binding inhibitory sequences against pp60 c−src identified using a random 15‐amino‐acid peptide library (1996) (44)
- Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells (2010) (43)
- Identification of CD44 as a cell surface marker for Müller glia precursor cells (2010) (43)
- Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene. (1997) (42)
- Stat3 as a potential therapeutic target for rheumatoid arthritis (2017) (42)
- Comparison of PCR results using scrape/exudate, syringe-sucked fluid and biopsy samples for diagnosis of cutaneous leishmaniasis in Ecuador. (1999) (42)
- p53 protein immunostaining in routinely processed paraffin-embedded sections. (1993) (41)
- Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation (2007) (41)
- Receptor protein tyrosine kinase DDR is up‐regulated by p53 protein (1996) (41)
- EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44. (2008) (41)
- Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma. (2003) (41)
- The CD44 adhesion molecule and metastasis. (1994) (40)
- Pro108Ser mutant of SARS-CoV-2 3CL pro Reduces the Enzymatic Activity and Ameliorates COVID-19 Severity in Japan (2020) (40)
- Glucose transporter 1‐mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors (2019) (40)
- Mad2 inhibits the mitotic kinesin MKlp2 (2010) (39)
- Decreased expression of neurofibromin contributes to epithelial–mesenchymal transition in neurofibromatosis type 1 (2009) (39)
- Proteolytic release of CD 44 intracellular domain and its role in the CD 44 signaling pathway (2001) (39)
- Periostin Is a Key Niche Component for Wound Metastasis of Melanoma (2015) (38)
- Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1. (2003) (38)
- Endothelium-induced three-dimensional invasion of heterogeneous glioma initiating cells in a microfluidic coculture platform. (2017) (38)
- Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression (2018) (38)
- Centrosome amplification in adult T‐cell leukemia and human T‐cell leukemia virus type 1 Tax‐induced human T cells (2006) (38)
- Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells (2012) (37)
- Statins Decrease Lung Inflammation in Mice by Upregulating Tetraspanin CD9 in Macrophages (2013) (37)
- Alternative RNA splicing of the hyaluronic acid receptor CD44 in the normal human brain and in brain tumors. (1995) (35)
- Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15 (2006) (35)
- The Anaphase-Promoting Complex/Cyclosome Activator Cdh1 Modulates Rho GTPase by Targeting p190 RhoGAP for Degradation (2010) (35)
- Development of a functional thyroid model based on an organoid culture system. (2018) (35)
- Comparative analysis of brain proteins from p53‐deficient mice by two‐dimensional electrophoresis (2000) (35)
- In vivo pH monitoring using boron doped diamond microelectrode and silver needles: Application to stomach disorder diagnosis (2013) (35)
- Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma (2019) (35)
- Tumor necrosis factor‐α modulates epithelial mesenchymal transition mediators ZEB2 and S100A4 to promote cholangiocarcinoma progression (2014) (34)
- ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma (2007) (34)
- ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells. (2019) (34)
- EpCAM expression in the prostate cancer makes the difference in the response to growth factors. (2014) (33)
- Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non‐small‐cell lung cancer (2017) (33)
- The ERK-RSK1 activation by growth factors at G2 phase delays cell cycle progression and reduces mitotic aberrations. (2008) (33)
- Molecular analysis of the h-warts/LATS1 gene in human breast cancer. (2000) (33)
- Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma (2012) (33)
- Calpain‐dependent proteolysis of NF2 protein: Involvement in schwannomas and meningiomas (2000) (33)
- CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis (2016) (32)
- Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells (2014) (32)
- ZEB1 expression is a potential indicator of invasive endometriosis (2017) (32)
- NE‐dlg, a mammalian homolog of drosophila dlg tumor suppressor, induces growth suppression and impairment of cell adhesion: possible involvement of down‐regulation of β‐catenin by NE‐dlg expression (2000) (32)
- Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407) (2017) (31)
- NKX2.2 suppresses self-renewal of glioma-initiating cells. (2011) (31)
- Molecularly targeted therapies for glioma (2009) (31)
- Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion. (2013) (30)
- TSPAN2 is involved in cell invasion and motility during lung cancer progression. (2014) (30)
- CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus‐positive patients with resected hepatocellular carcinoma (2016) (30)
- Epidemiology, cytogenetics, and molecular biology of brain tumors. (1993) (30)
- Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor (2011) (29)
- Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy. (2011) (29)
- Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors (2016) (29)
- Neuroprotective effects of memantine via enhancement of autophagy. (2019) (29)
- Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer (2018) (29)
- Direct sequencing analysis of transmembrane region of human neu gene by polymerase chain reaction (2006) (28)
- Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma (2017) (28)
- Prognostic value of proliferating cell nuclear antigen expression in chronic lymphoid leukemia. (1992) (28)
- The Arf/p53 Protein Module, Which Induces Apoptosis, Down-regulates Histone H2AX to Allow Normal Cells to Survive in the Presence of Anti-cancer Drugs* (2013) (28)
- Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts (2016) (27)
- Proliferating cell nuclear antigen (PCNA) expression in chronic lymphocytic leukemia (CLL). (1993) (27)
- The use of next-generation sequencing in molecular diagnosis of neurofibromatosis type 1: a validation study. (2014) (27)
- cRGD peptide installation on cisplatin‐loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem‐like cells (2017) (26)
- Sulfasalazine could modulate the CD44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer (2019) (26)
- Katanin p60 Contributes to Microtubule Instability around the Midbody and Facilitates Cytokinesis in Rat Cells (2013) (26)
- Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization. (2009) (26)
- Real-time in vivo imaging of p 16 Ink 4 a reveals cross talk with p 53 (2009) (25)
- N-cadherin upregulation mediates adaptive radioresistance in glioblastoma. (2021) (25)
- AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3β (2008) (25)
- Tissue culture methods to study neurological disorders: Establishment of immortalized Schwann cells from murine disease models (2003) (25)
- Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer. (2016) (24)
- Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells. (2016) (24)
- Myeloid Differentiation Factor 88 Signaling in Bone Marrow–Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment (2016) (24)
- Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan (2021) (24)
- NDEL 1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation , Separation , and TACC 3 Recruitment † (2006) (24)
- Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling. (2013) (24)
- Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staff (2022) (23)
- Alternative splicing of neurofibromatosis type 1 gene transcript in malignant brain tumors: PCR analysis of frozen‐section mRNA (1992) (23)
- Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma (2020) (23)
- A Novel NE-dlg/SAP102-associated Protein, p51-nedasin, Related to the Amidohydrolase Superfamily, Interferes with the Association between NE-dlg/SAP102 and N-Methyl-d-aspartate Receptor* (1999) (23)
- Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis (2017) (23)
- Organotypic brain explant culture as a drug evaluation system for malignant brain tumors (2017) (23)
- Inhibition of the association with nuclear matrix of pRB, p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin, an inhibitor of Src tyrosine kinase. (1995) (23)
- Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma (2017) (23)
- RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis (2017) (23)
- Targeting of cancer stem cells by differentiation therapy (2020) (23)
- Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer (2021) (23)
- Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability (2002) (23)
- A hypothesis for myeloschisis: overgrowth and reopening. An experimental study. (1988) (22)
- Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury (2017) (21)
- Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells (2019) (21)
- Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis – Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial) (2019) (21)
- A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population (2014) (21)
- Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. (1999) (20)
- 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche (2020) (20)
- A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. (1999) (20)
- Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry. (2015) (20)
- ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN (2016) (20)
- Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. (2013) (19)
- Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension. (2019) (19)
- Visualization of spatiotemporal dynamics of human glioma stem cell invasion (2019) (19)
- Variant isoforms of CD44 expression in upper tract urothelial cancer as a predictive marker for recurrence and mortality. (2016) (19)
- Potential of sulfasalazine as a therapeutic sensitizer for CD44 splice variant 9-positive urogenital cancer (2016) (19)
- A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model (2019) (19)
- Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B‐containing N‐methyl‐d‐aspartate–sensitive glutamate receptor signaling (2018) (18)
- A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes. (2014) (18)
- Up-Regulation of Imp3 Confers In Vivo Tumorigenicity on Murine Osteosarcoma Cells (2012) (18)
- PML‐nuclear bodies are involved in cellular serum response (2003) (18)
- HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer (2018) (17)
- Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma (2017) (17)
- Clinical utility of SARS-CoV-2 whole genome sequencing in deciphering source of infection (2020) (17)
- APCCDH1 Targets MgcRacGAP for Destruction in the Late M Phase (2013) (17)
- Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12. (2011) (17)
- Bacterial expression of an active tyrosine kinase from a protein A/truncated c‐src fusion protein (1993) (16)
- Radiation induction of the receptor tyrosine kinase gene Ptk-3 in normal rat astrocytes. (1995) (16)
- Twist2 functions as a tumor suppressor in murine osteosarcoma cells (2013) (16)
- Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy (2019) (16)
- Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2 (2009) (16)
- FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia. (2017) (15)
- Retracted: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐κB activity (2009) (15)
- Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. (2016) (15)
- Calcitriol exerts an anti‐tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response (2017) (15)
- Expression of random peptide fused to invasin on bacterial cell surface for selection of cell-targeting peptides. (2000) (15)
- Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells (2015) (15)
- Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas. (1998) (15)
- Calpain‐dependent proteolysis of merlin occurs by oxidative stress in meningiomas (2001) (15)
- RT-PCR Screening Tests for SARS-CoV-2 with Saliva Samples in Asymptomatic People: Strategy to Maintain Social and Economic Activities while Reducing the Risk of Spreading the Virus. (2021) (15)
- Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma. (2021) (14)
- Pro108Ser mutant of SARS-CoV-2 3CLpro reduces the enzymatic activity and ameliorates COVID-19 severity in Japan (2020) (14)
- Pathways of oncogenesis in primary brain tumors. (1991) (14)
- Molecular pathology underlying the robustness of cancer stem cells (2021) (14)
- TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma (2021) (14)
- Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis (2015) (14)
- Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells (2017) (14)
- Restoration of endogenous wild‐type p53 activity in a glioblastoma cell line with intrinsic temperature‐sensitive p53 induces growth arrest but not apoptosis (2001) (14)
- Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents (2016) (14)
- Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes. (2013) (13)
- An evolutionarily conserved leucine-rich repeat protein CLERC is a centrosomal protein required for spindle pole integrity (2008) (13)
- Reversible whole-organism cell cycle arrest in a living vertebrate (2009) (13)
- Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases (2015) (13)
- The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells. (1999) (13)
- The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress (2011) (13)
- Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect. (2020) (13)
- Modeling phenotypes of malignant gliomas (2017) (12)
- [Redox regulation in cancer stem cells]. (2015) (12)
- Evaluation of the usability of various rapid antibody tests in the diagnostic application for COVID-19 (2020) (12)
- Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells (2018) (12)
- CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake (2018) (12)
- Periostin antisense oligonucleotide suppresses bleomycin‐induced formation of a lung premetastatic niche for melanoma (2018) (11)
- Application of polymerase chain reaction for rapid subcloning of cDNA inserts from λgt11 clones (1990) (11)
- GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development (2016) (11)
- Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19 (2022) (11)
- Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma (2020) (11)
- LATS1 and LATS2 Phosphorylate CDC26 to Modulate Assembly of the Tetratricopeptide Repeat Subcomplex of APC/C (2015) (11)
- Glycan profiling of gestational choriocarcinoma using a lectin microarray. (2014) (11)
- Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor (2015) (10)
- Multiple café au lait spots in familial patients with MAP2K2 mutation (2014) (10)
- Blood and lymphatic systems are segregated by the FLCN tumor suppressor (2020) (10)
- Establishment of HRASG12V Transgenic Medaka as a Stable Tumor Model for In Vivo Screening of Anticancer Drugs (2013) (10)
- Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cells. (1997) (10)
- FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells (2021) (10)
- Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice (2018) (10)
- The insulin‐PI3K‐Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics (2020) (10)
- Polyclonal uses of T‐cell receptor (TCR)α and β genes for cytotoxic T lymphocytes in human metastatic melanoma: possible involvement of TCRα in tumor‐cell recognition (1994) (9)
- Ink4a/Arf−/− and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f− quiescent cells (2013) (9)
- Monitoring adenoviral p53 transduction efficiency by yeast functional assay (1998) (9)
- Detection of human glioma-associated antigen by rat monoclonal antibody raised against syngeneic rat glioma cells. (1986) (9)
- Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model (2019) (9)
- The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells. (2013) (9)
- Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model (2017) (9)
- Functional analysis of a novel glioma antigen, EFTUD1. (2014) (9)
- Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models (2022) (9)
- Nakamura, H. et al. Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55. FEBS Lett. 433, 63-67 (1998) (9)
- Caspase activation in neuronal and glial apoptosis following spinal cord injury in mice. Commentary (2003) (9)
- Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding. (1997) (9)
- Pineoblastoma with neuronal differentiation — Immunohistochemical and immunocytochemical studies (2006) (9)
- Differential splicing of the neurofibromatosis type-1 gene in the rat - splice variants homologous with the human are expressed in rat-cells. (1992) (9)
- Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta. (2013) (9)
- Neurofibromatosis type 1 (NF1) gene: Implication in neuroectodermal differentiation and genesis of brain tumors (1991) (9)
- CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment. (2017) (9)
- Lactate Reprograms Energy and Lipid Metabolism in Glucose-Deprived Oxidative Glioma Stem Cells (2021) (8)
- Oncogenic KRAS–expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice (2020) (8)
- Molecular, genetic, and biologic aspects of primary brain tumors (1993) (8)
- Structural alterations of the p53 gene in human leukemias. (1992) (8)
- Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models (2020) (8)
- Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells. (2017) (8)
- Study of autoantibodies against advanced glycation endproducts of the Maillard reaction (2001) (8)
- Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness (2022) (7)
- Impair Cytokinetic Segregation of Glial Filaments (1998) (7)
- Differential levels of human leukocyte antigen-class I, multidrug-resistance 1 and androgen receptor expressions in untreated prostate cancer cells: the robustness of prostate cancer. (2007) (7)
- Correction: RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI3 Kinase/Akt Signaling Pathways (2012) (7)
- Reduced tumorigenicity and cell motility of a gastric-carcinoma cell-line by introduction of wild-type p53 gene. (1993) (6)
- Transient depletion of p 53 followed by transduction of c-Myc and KRas converts ovarian stem-like cells into tumor-initiating cells (2011) (6)
- Identification of kit-ligand a as the Gene Responsible for the Medaka Pigment Cell Mutant few melanophore (2019) (6)
- Experimental therapies: Investigator-initiated cancer trials with INDs for approval in Japan (2010) (6)
- Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression (2017) (6)
- 1 xCT inhibition depletes CD 44 v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma (2013) (6)
- Role of alternative splicing of the rat erythropoietin receptor gene in normal and erythroleukemia cells. (1997) (6)
- Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases. (2020) (6)
- Loss of merlin-p85 protein complex in NF2-related tumors. (1998) (6)
- Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patients (2022) (6)
- The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma (2020) (5)
- Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1α axis. (2013) (5)
- [Cancer stem cells in malignant glioma-the mechanism of cancer initiation and the therapeutic development]. (2010) (5)
- Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer (2018) (5)
- Reciprocal Control of G1-Phase Progression Is Required for Th-POK/Runx3–Mediated CD4/8 Thymocyte Cell Fate Decision (2012) (5)
- Application of clotrimazole via a novel controlled release device provides potent retinal protection (2015) (5)
- Mad 2 inhibits the mitotic kinesin MKlp 2 (2010) (5)
- Technetium-99m sestamibi single photon emission computed tomography findings correlated with P-glycoprotein expression, encoded by the multidrug resistance gene-1 messenger ribonucleic acid, in intracranial meningiomas. (2003) (5)
- Report on the use of non‐clinical studies in the regulatory evaluation of oncology drugs (2016) (4)
- The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery (2019) (4)
- Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell (2020) (4)
- Heterogeneous glioma cell invasion under interstitial flow depending on their differentiation status. (2021) (4)
- Detection of p53 alterations in human astrocytomas using frozen tissue sections for the polymerase chain reaction. (1993) (4)
- Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d (2020) (4)
- CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression (2021) (4)
- MEK inhibition suppresses metastatic progression of KRAS‐mutated gastric cancer (2021) (4)
- The Novel Anti-tumor Therapy Targeting the Functional Cancer StemCell Markers (2014) (4)
- The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis (2021) (4)
- Functional analysis of HOXD 9 in human gliomas and glioma cancer stem cells (2018) (4)
- Erratum: Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling (Biochemical and Biophysical Research Communications (2013) 438 (640-646)) (2013) (4)
- Functional analysis of APC-Cdh1. (2004) (4)
- Protein-tyrosine kinase activity and pp60v-src expression in whole cells measured by flow cytometry. (1988) (4)
- Severity of COVID-19 is inversely correlated with increased number counts of non-synonymous mutations in Tokyo (2020) (4)
- Increase in the capability of interleukin 2 gene-transduced renal cell carcinoma cells to induce cytotoxic lymphocytes. (1994) (3)
- Detection ofp53 alterations in human astrocytomas using frozen tissue sections for the polymerase chain reaction (1993) (3)
- Two novel genes in melanoma metastases: 248 (1993) (3)
- Derivation of a brain tumor-selective monoclonal antibody from hybridoma between mouse myeloma and rat spleen cells immune to syngeneic glioma. (1985) (3)
- MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo (2021) (3)
- STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: An open label, phase I/IIa trial (2022) (3)
- Isolation and characterization of neural stem/progenitor cells in the subventricular zone of the naked mole-rat brain (2021) (3)
- Development of an in vitro carcinogenesis model of human papillomavirus‐induced cervical adenocarcinoma (2021) (3)
- Transfection of wild-type TP53 induces differentiation in human gingival carcinoma cells. (1996) (3)
- Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis (2022) (3)
- Evaluating the effect of Tranilast for pelvic pain caused by endometriosis (2013) (3)
- Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway (2020) (2)
- Abstract 211: Sulfasalazine (SSZ) works cancer stem-like cells (CSCs) via inhibiting xCT signal pathway: Phase 1 study in patients with gastric cancer (EPOC 1205) (2014) (2)
- [Neurofibromatosis type 2 (NF2)]. (1997) (2)
- Establishment of pten knockout medaka with transcription activator–like effector nucleases (TALENs) as a model of PTEN deficiency disease (2017) (2)
- Abstract 4182: Statins induce apoptosis in osteosarcoma cells by activation of Ampk and p38-MAPK via suppression of mevalonate pathway (2016) (2)
- Discovery, development, and testing of substrates and inhibitors of pp60c-SRC (1995) (2)
- A phase I/IIa trial of the RNA oligonucleotide STNM01 by EUS-FNI to investigate the safety and efficacy in patients with first-line refractory, unresectable pancreatic cancer. (2021) (2)
- Observation of the Intracellular Behavior of Recombinant Yersinia pseudotuberculosis Invasin Protein (2005) (2)
- Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2021) (2)
- [Role of CD44-mediated signal in cancer invasion and metastasis]. (2008) (2)
- Impact of coronavirus disease 2019 on the number of newly diagnosed cancer patients and examinations and surgeries performed for cancer in Japan: a nationwide study (2022) (2)
- Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant. (2022) (2)
- IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer (2023) (2)
- Antigen common to several species, recognized by a rat monoclonal antibody raised against syngeneic rat bladder tumor (1989) (2)
- Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor (2016) (2)
- COMPARATIVE STUDY OF RANDOM AMPLIFIED POLYMORPHIC DNA OF TRYPANOSOMA CRUZI ISOLATES FROM PARAGUAY (1999) (2)
- Molecular pathogenesis and management of gliomas (1993) (2)
- [Dynamics of mitotic spindle]. (2006) (2)
- Emerging therapeutic targets in schwannomas and meningiomas: the neurofibromatosis Type 2 protein (1999) (1)
- Abstract 3078: IGF1/N-cadherin/b-catenin/Clusterin signaling axis can mediates adaptive radioresistance in glioblastoma (2021) (1)
- Patients with Glioblastoma Multiforme Prognostic Value of Epidermal Growth Factor Receptor in Updated (2003) (1)
- MS 26.01 Therapeutic Strategies Targeting Cancer Stem Cells (2017) (1)
- Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice. (2020) (1)
- SARS-CoV-2 Infection among Medical Institution Faculty and Healthcare Workers in Tokyo, Japan (2021) (1)
- Characterization of a novel BBB-permeable mutant IDH1 inhibitor, DS-1001b (2019) (1)
- Role of the Cell Cycle Regulator Cdh1 in Physiology and Pathology of Hematopoiesis (2011) (1)
- [Cellular signal transduction via the neurofibromatosis type 2 tumor suppressor gene product; merlin]. (1999) (1)
- [Therapeutic strategy for breast cancer stem cells]. (2012) (1)
- Assessing anti‐SARS‐CoV‐2 cellular immunity in 571 vaccines by using an IFN‐γ release assay (2022) (1)
- Effect of sulfasalazine (SSZ) on cancer stem-like cells (CSCs) via inhibiting xCT signal pathway: Phase 1 study in patients with gastric cancer (EPOC 1205). (2014) (1)
- MP29-05 PROGNOSTIC SIGNIFICANCE OF TNF-α AND CD44 EXPRESSION IN CLEAR CELL RENAL CELL CARCINOMAS: IMPLICATION OF CANCER INVASION, METASTASIS, AND RESISTANCE TO SUNITINIB TREATMENT (2014) (1)
- Tumor and Stem Cell Biology CD 44 s Regulates the TGF-b – Mediated Mesenchymal Phenotype and Is Associatedwith Poor Prognosis in Patients with Hepatocellular Carcinoma (2012) (1)
- Author Correction: CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake (2020) (1)
- Tumor Burden Monitoring with Circulating Tumor DNA During Treatment in Patients with Esophageal Squamous Cell Carcinoma. (2023) (1)
- Antifungal Agent Luliconazole Inhibits the Growth of Mouse Glioma-initiating Cells in Brain Explants. (2020) (1)
- Abstract 65:Ink4a/Arflocus drives gastric tumorigenesis through induction of parietal cell loss (2014) (1)
- DETECTION OF p53 PROTEIN IN GLIOMAS: 186 (1990) (1)
- Abstract 1078: TGF-β and TNF-α activate gene transcription programs associated with poor breast cancer prognosis (2015) (1)
- Abstract 522: The epithelial-mesenchymal transition-related transcription factor ZEB suppressesClaudinexpression in breast cancer cells. (2013) (1)
- Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H‐Ras (2016) (1)
- [Encounter of cancer cells with bone. The significance of cancer stem cells and epithelial-mesenchymal transition in tumor invasion and metastasis]. (2011) (1)
- Modification of a commercially available method of extracting plasmid DNA. (1990) (1)
- Assessment of humoral responses in COVID-19 using various quantitative antibody tests (2021) (1)
- Gene therapy using genome‐edited iPS cells for targeting malignant glioma (2022) (1)
- Abstract 4192: The association between gastric Mucin 5AC (MUC5AC) expressions, transforming growth factor-β (TGF-β) signal, and histopathological phenotypes of lung cancer in xenograft models (2016) (1)
- [Molecular mechanisms of brain tumor invasion]. (2005) (1)
- Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors. (2022) (1)
- Abstract 4758: Benzaldehyde suppresses multiple signal pathways in cancer cells by regulating 14-3-3ζ-mediated protein-protein interactions (2016) (1)
- [Molecular mechanism regulating effect of anti-cancer agents]. (2009) (1)
- Abstract 979: Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression (2015) (1)
- Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent (2018) (1)
- Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant. (2022) (1)
- Pigment epithelium-derived factor promotes peritoneal dissemination of ovarian cancer through induction of immunosuppressive macrophages (2022) (1)
- Profiling analysis for gene expression and glycan structure in extravillous trophoblast cells with neoplastic transformation (2014) (0)
- Abstract B06: EpCAM functions as a sensor that allows prostate cancer cells to become quiescent in response to lack of growth factors. (2015) (0)
- Abstract 432: xCT inhibition disrupts redox homeostasis in CD44v-expressing tumor cells showing glutaminolytic metabolism in head and neck squamous cell carcinoma (2017) (0)
- Abstract 2458: Genetically induced cancer stem cells (CSCs) in mouse mammary gland from Ink4a/Arf-knockout mammary cells transduced with H-rasG12V (2010) (0)
- Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer (2022) (0)
- Abstract PR02: Dynamic epigenetic regulation of glioblastoma tumorigenicity through a LSD1-MYC-OLIG2 axis (2015) (0)
- Role of CD24 in HER2-positive breast cancer. (2014) (0)
- Abstract 5202: Pigment epithelium-derived factor promotes tumor dissemination of ovarian cancer cells through an interaction with peritoneal immune system (2018) (0)
- Injury promotes melanoma metastasis via wound healing process with periostin (2016) (0)
- Arf and Ink4a Are Critical Factors Determining the Cell of Origin and Therapeutic Sensitivity in Myc-Induced Mouse Lymphoid Tumor (2011) (0)
- Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy (2005) (0)
- [Multiple aneurysms on the horizontal portion of the anterior cerebral artery (A-1)]. (1985) (0)
- Redox regulation of stem-like cancer cells by CD44 (2013) (0)
- [Mitotic regulation and carcinogenesis]. (2009) (0)
- EPIG-02DYNAMIC EPIGENETIC MODULATION OF GLIOBLASTOMA TUMORIGENICITY BY INHIBITION OF LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) (2015) (0)
- INTEGRATED ANALYSIS IDENTIFIES DIFFERENT METABOLIC SIGNATURES WITHIN BOTH TUMOR-INITIATING CELLS AND STEM CELLS IN A MURINE GLIOBLASTOMA MODEL (2014) (0)
- [p53 mutations in brain tumors]. (2016) (0)
- Molecular biology of tumor suppressor genes related to cell adhesion signalings (1998) (0)
- Nature of T cell recognition of self -and nonself-peptides : its implication to anti-tumor immunity (1998) (0)
- Cell Cycle and Senescence Energy Management by Enhanced Glycolysis in G 1-phase in Human Colon Cancer Cells In Vitro and In Vivo (2013) (0)
- Abstract P1-03-02: Development of a Novel Animal Model of Human Triple-Negative Breast Cancer by Retroviral Oncogene Transduction of Mouse Mammary Stem Cells (2010) (0)
- Correction to: An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment (2022) (0)
- Microsatellite analysis of chromosome 10q in malignant glioma (1996) (0)
- Abstract 2283: Novel mouse model for mature B cell lymphoma reveals the requirement of Fas downregulation in lymphomagenesis (2015) (0)
- Effect of heterogeneity of HER2 expression on brain metastases of breast cancer. (2012) (0)
- Abstract 2348: BRD4 regulates the expression of Livin and thereby confers resistance to Fas-mediated immune cytotoxicity in aggressive B-cell lymphoma (2019) (0)
- Implication of cell cycle dysregulation in development and malignant progression of tumors (2004) (0)
- Author Correction: CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake (2020) (0)
- Abstract 3098: Myc preferentially transforms hematopoietic stem cells into Precursor B cell lymphoblastic leukemia/lymphoma (2010) (0)
- MP63-08 CD44 VARIANT 9 EXPRESSION IS A NOVEL INDICATOR FOR IDENTIFYING POOR SURVIVAL IN PATIENTS WITH INVASIVE UROTHELIAL CARCINOMA (2019) (0)
- Erratum: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity (International Journal of Cancer 124 (2607-2615)) (2011) (0)
- New role of mitotic kinase Lats1/warts on cochlear stereocilia (2016) (0)
- Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer (2018) (0)
- Real-time in vivo imaging of p16Ink4areveals cross talk with p53 (2009) (0)
- Human Metabolomic Systems Biology Human Metabolomic Systems Biology (2008) (0)
- Msy1–1INVESTIGATOR-INITIATED TRIAL FOR PMDA APPROVAL IN COLLABORATION WITH THE US NCI/CTEP (2013) (0)
- Molecular and cellular mechanisms underlying brain metastasis of breast cancer (2020) (0)
- STEM-16. IGF1/N-CADHERIN/b-CATENIN/CLUSTERIN SIGNALING AXIS MEDIATES ADAPTIVE RADIORESISTANCE IN GLIOBLASTOMA (2020) (0)
- Abstract 3331: CD24 promotes HER2 signaling pathways and CD24 inhibition sensitizes anti-HER2 therapy in breast cancer (2014) (0)
- Early symptoms preceding post-infectious irritable bowel syndrome following COVID-19: a retrospective observational study incorporating daily gastrointestinal symptoms (2023) (0)
- Abstract 857: ELF3 modulates mesenchymal to epithelial transition through regulation of CD44 variant isoform expression in pancreatic cancer cells (2017) (0)
- chronic lymphoid leukemia Prognostic value of proliferating cell nuclear antigen expression in (2011) (0)
- 5. Implication of cell cycle abnormalities in oncogenesis and a new concept of cancer therapy (B4 Pathology and molecular biology of brain tumors) (2004) (0)
- Sustained clotrimazole release attenuates light-induced retinal damage through modulation of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) (2014) (0)
- Novel strategies for cancer stem cells (2012) (0)
- Sa1900 CD44v9 Results in Resistance to Trastuzumab via Induction of ROS Resistance (2014) (0)
- Abstract 4639:SLC7A11expression confers cancer stem-like properties in small cell lung cancer cells (2019) (0)
- 1C24 A MICROFLUIDIC INVASION ASSAY FOR GLIOMA-INITIATING CELLS WITH HUVEC IN THREE-DIMENSIONAL CULTURE (2014) (0)
- Abstract 6097: Determination of BRCA2 deletion status by copy number estimation using next generation sequencing to predict prognosis of clinically localized prostate cancer (2023) (0)
- Molecular mechanisms of anti-cancer therapies (2006) (0)
- Molecular mechanism of tumorigenesis by cell cycle regulation and new therapeutical approaches (2005) (0)
- PD04-01 EVALUATION OF COPY NUMBER AND ALLELIC IMBALANCE OF BRCA2 BY NEXT-GENERATION SEQUENCING TO PREDICT PROGNOSIS AND DRUG SENSITIVITY IN PROSTATE CANCER (2023) (0)
- [Aurora kinases: Functions and roles in tumorigenesis]. (2007) (0)
- Correlation between resistant for toxic substance, EMT and transformation by long-term culture with toxic substance of liver culture cells (2016) (0)
- Involvement of Hyarulonan With Choroidal Neovascularization (2008) (0)
- PTEN knockout medaka: analysis of the mutated phenotype detected in embryos and its application as a disease model (2016) (0)
- Abstract P3-07-58: CD44v as a potential predictive biomarker for pathologic complete response in primary HER2+ breast cancer: Utility of adaptive response biopsy in preoperative therapy (2016) (0)
- Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival (2018) (0)
- Skin-infiltrating CD4+ lymphoma cells depend on hair follicle-derived IL-7 (2016) (0)
- Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation (2022) (0)
- Tokuda Akihiro Tomida Shinya Toyokuni Hitoshi Tsuda Shoichiro Tsugane Tatsuhiko Tsunoda Heiichiro Udono Koji Ueda Yoshimasa Uehara Hiroo Ueno Kazuo Umezawa Toshikazu Ushijima Toshihiko Wakabayashi Kenji Wakai Tetsuro Watabe (2016) (0)
- CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake (2018) (0)
- Supplementary Table legends (2013) (0)
- Application of polymerase chain reaction for rapid subcloning of cDNA inserts from lambda gt11 clones. (1990) (0)
- Abstract C89: ESRP1-CD44v-xCT axis as a potential therapeutic target for the metastasis (2013) (0)
- A Novel Anti-cancer Strategy Targeting CD44-positive Cancer Stem Cells (2016) (0)
- Osteopontin-Mediated Enhanced Hyaluronan Binding Induces Multidrug Resistance in Mesothelioma Cell. (2009) (0)
- Abstract 4342: Crosstalk between initiating cells with different metabolism in a murine model of malignant glioma (2014) (0)
- 1030 POSTER Re-expression of p16 Mediates Apoptosis in Cholangiocarcinoma With Low Rb Level (2011) (0)
- Abstract 3418: Additional mutation inPTPN11gene promotes tumorigenesis of theNF1gene mutated cells (2017) (0)
- Comprehensive assessment of cancer stem cell like cells in prediction of pathologic complete response to preoperative dual anti–HER2 therapy for HER2–positive primary breast cancer. (2017) (0)
- Loss of Function of The Cell Cycle Regulator Cdh1 Causes Cell Fragility due to Aberrant G2/M Checkpoint and Develops Resistant Disease in a B-ALL/LBL Mouse Model (2013) (0)
- Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo (2022) (0)
- Oncogenes and tumor suppressor genes (1996) (0)
- MP83-10 CD44V8-10 INVOLVES ACQUISITION OF CISPLATIN-RESISTANCE IN UROTHELIAL CANCER (2016) (0)
- Polyclonal uses of T-cell receptor (TCR)alpha and beta genes for cytotoxic T lymphocytes in human metastatic melanoma: possible involvement of TCR alpha in tumor-cell recognition. (1994) (0)
- CD44 variant-dependent redox status regulation in liver fluke-associated cholangiocarcinoma: a target for CCA treatment. (2016) (0)
- CBIO-17EXPRESSION AND FUNCTIONAL ANALYSIS OF AN ONCOANTIGEN, DEPDC1, IN MALIGNANT GLIOMA (2015) (0)
- Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells (2018) (0)
- Screening of p53 mutations in lung cancers using a yeast functional assay: Investigation of relationship between p53 mutations and pulmonary fibrosis or clinical parameters (2000) (0)
- Novel treatment strategy for endometriosis: Targeting epithelial-mesenchymal transition. (2019) (0)
- Variant isoforms of CD44 expression as predictive markers for mortality in surgically treated patients with locally advanced upper tract urothelial carcinoma. (2016) (0)
- MP04-11 TARGETING GLUTAMINE ADDICTION WITH POTENT DRUG COMBINATION THERAPY FOR RENAL CELL CARCINOMA (2023) (0)
- Abstract 3972: Novel renal cell carcinoma therapy targeting glutaminolysis (2023) (0)
- Expression and phosphorylation of a clustering molecule, NE-dlg/SAP102 in cultured hippocampal neurons (2000) (0)
- Abstract P1-07-02: Significance of RB-ZEB axis in EMT phenotype of breast cancer and inhibition of ZEB by CDK4/6 inhibitor (2013) (0)
- Abstract 4967: ESRP1 regulated alternative splicing of CD44mRNA enhances lung colonization of metastatic cancer cell (2014) (0)
- Analysis of cancer metabolism by surface enhanced Raman imaging (2018) (0)
- Robotic crowd biology with Maholo LabDroids (2017) (0)
- ASO Visual Abstract: Tumor Burden Monitoring with Circulating Tumor DNA During Treatment in Patients with Esophageal Squamous Cell Carcinoma. (2023) (0)
- Abstract PR13: Epigenetic regulation of MYC drives dynamic transition between tumor initiating states in glioblastoma (2015) (0)
- Abstract 5311: Establishment of neurofibroma cells and dedifferentiated fat (DFAT) cells from tumor tissues from patients diagnosed with NF1 (Neurofibromatosis type 1) (2019) (0)
- Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality (2017) (0)
- Protein-Tyrosine Kinase Activity and pp 60 " ~ ircExpression in Whole Cells Measured by Flow Cytometry 1 (2006) (0)
- Stat3 as a potential therapeutic target for rheumatoid arthritis (2017) (0)
- [Cell kinetic analysis of human brain tumors by bivariate flow cytometric measurement of cellular DNA content and amount of incorporated bromodeoxyuridine]. (1989) (0)
- cells into triple-negative breast cancer containing tumorigenic CD49fquiescent cells (2013) (0)
- Abstract 2041: Development and analysis of mouse brain tumor models derived from neural stem cells expressing activated ALK (2014) (0)
- Abstract 2730: Additional mutations in genes relevant to the Ras signaling pathway promote the malignant characteristics of NF1-associated malignant peripheral nerve sheath tumor (NF1-MPNST) cells (2015) (0)
- Pixel-Level Clustering of Hematoxylin–Eosin-Stained Sections of Mouse and Human Biliary Tract Cancer (2022) (0)
- Tranilast inhibits pulmonary fibrosis by suppressing TGFβ-mediated extracellular matrix protein production (2013) (0)
- Molecular biology of malignant brain tumors (1997) (0)
- Abstract LB-163: Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells (2012) (0)
- Abstract 3719: xCT inhibition suppresses CD44v-positive stem-like tumor cells, which are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma. (2013) (0)
- Tks5-dependent formation of circumferential podosomes mediates cell-cell fusion (2012) (0)
- Abstract 5424: CD44-mediated glucose metabolism affects ROS level and drug sensitivity in glycolytic cancer cells. (2013) (0)
- Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models (2022) (0)
- [Molecular mechanism of cell death induced by chemotherapeutic agents]. (2009) (0)
- 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche (2020) (0)
- Abstract P2-04-01: Development of mouse breast cancer models based on induced cancer stem cells (iCSC). (2012) (0)
- CB-04EPIGENETIC REGULATION OF GLIOBLASTOMA TUMORIGENICITY: A HYBRID MODEL (2014) (0)
- Abstract 2376: Mouse mammary tumor model relevant to human triple negative breast cancer (2011) (0)
- P3.02c-001 Phase I Study of Salazosulfapyridine Targeting Cancer Stem Cells in Combination with CDDP and Pemetrexed for Chemo-Naïve Advanced Non-Sq NSCLC: Topic: Targeted Therapy (2017) (0)
- Molecular and Cellular Pathobiology Acquired Expression of NFATc 1 Downregulates E-Cadherin and Promotes Cancer Cell Invasion (2013) (0)
- Cell Death: Its Style and Significance (2005) (0)
- Abstract 914: The role of CD44 variant in the development of spasmolytic polypeptide-expressing metaplasia (SPEM) and gastric cancer (2011) (0)
- Abstract 2156: Lung niche factors for progenitor cell self-renewal sustain lung cancer stem cells and contribute to drug resistance to kinase inhibitors in non-small cell lung cancer (2018) (0)
- Visualization of spatiotemporal dynamics of human glioma stem cell invasion (2019) (0)
- Basic biology of gliomas (2014) (0)
- Explore for EMT related gene by network medicine analysis in human lung cancer cell (2017) (0)
- Cd44 alternative splicing in human tumors (1992) (0)
- Generation of metabolically functional hepatocyte-like cells from dedifferentiated fat cells by Foxa2, Hnf4a and Sall1 transduction (2021) (0)
- Abstract 2874: Benzaldehyde inhibits the multiple signals in cancer by suppressing the binding activity of overexpressed 14-3-3ζ and represses the pRb/E2F transcriptional pathway (2018) (0)
- RT-21Mre11-Rad50-Nbs1 COMPLEX INHIBITOR MIRIN ENHANCES RADIOSENSITIVITY IN HUMAN GLIOBLASTOMA CELLS (2014) (0)
- Su1724 Expression of CD44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Through Anti-Oxidative Stress Mechanism (2013) (0)
- LAB-STEM CELLS (2012) (0)
- Identification of CD44 transcripts that segregate with proliferation, redox and differentiation activities in human epidermal keratinocytes (2016) (0)
- Memory B cells and memory T cells induced by SARS-CoV-2 booster vaccination or infection show different dynamics and efficacy to the Omicron variant (2022) (0)
- Abstract 1430: N-cadherin is a driver of adaptive radioresistance in malignant brain tumors (2022) (0)
- A Three-Dimensional Invasion Assay for Glioma-Initiating Cells in a Microfluidic Device (2013) (0)
- Abstract 409: Analysis of invasion patterns in an induced cancer stem cell model of malignant brain tumor (2010) (0)
- Ropinirole Hydrochloride Remedy for Amyotrophic Lateral Sclerosis (P3.9-052) (2019) (0)
- Abstract LB-334: xCT promotes malignant phenotypes in EGFR-expressing glioma (2017) (0)
- Abstract 1227: Esophageal cancer shows spontaneous plasticity between epithelial and mesenchymal status (2023) (0)
- Abstract A55: Role of EpCAM in maintenance of stemness of cancer cells. (2011) (0)
- Molecular mechanism for development of malignant tumors: Does elucidation of molecular mechanisms contribute to the development of new therapeutic approaches? (2002) (0)
- Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue (2023) (0)
- Phosphorylation of the Anaphase Promoting Complex activator CDH1/FZR regulates the transition from Meiosis I to Meiosis II in mouse male germ cell (2020) (0)
- Identification of drugs that induce synthetic lethality with xCT inhibitors in the xCT inhibitor-resistant cancer cells (2019) (0)
- 866 Where does renal cell carcinoma get cysteine for antioxidants from (2015) (0)
- Abstract 238: IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells. (2013) (0)
- The 7th Japan and US Collaboration Conference in Gastroenterology (2013) (0)
- JS5. the characteristics and clinical significance of cancer stem cell (2012) (0)
- MP01-02 SULFASALAZINE COULD MODULATE THE CD44V9-XCT SYSTEM AND ENHANCE CDDP-INDUCED CYTOTOXIC EFFECTS IN METASTATIC BLADDER CANCER; A NOVEL THERAPEUTIC STRATEGY FOR METASTATIC BLADDER CANCER (2020) (0)
- Human nedd-4 as a family member of ubiquitin ligases (1997) (0)
- Abstract 1983: Enriching EpCAM+/Sca-1+ mouse bronchioalveolar stem cells to generate lung adenocarcinoma (2018) (0)
- Title Report on the use of non-clinical studies in the regulatoryevaluation of oncology drugs (2019) (0)
- [Therapy for pre-and postoperative diabetes insipidus of parasellar tumors by Desmopressin]. (1982) (0)
- Correction: LATS1 and LATS2 Phosphorylate CDC26 to Modulate Assembly of the Tetratricopeptide Repeat Subcomplex of APC/C (2015) (0)
- Overexpression of heparin-binding growth-associated molecule in malignant glioma cells. Commentary (2004) (0)
- Abstract 5164: Mesenchymal differentiation potentials modify osteosarcoma stem cell activities (2010) (0)
- Reporter/Functional gene transfer in rat brain. (2000) (0)
- Correction: RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI3 Kinase/Akt Signaling Pathways (2013) (0)
- Lipidomic Analyses Uncover Apoptotic and Inhibitory Effects of Pyrvinium Pamoate on Cholangiocarcinoma Cells via Mitochondrial Membrane Potential Dysfunction (2020) (0)
- ASO Author Reflections: Can Circulating Tumor DNA Guide Individualized Treatment for Patients with Esophageal Squamous Cell Carcinoma? (2023) (0)
- Abstract 2673: The cytoplasmic adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis (2021) (0)
- Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell (2020) (0)
- P1.02-023 TGF-β Signaling Mediated by Fibroblasts is Associated with the Histological Subtypes of Lung Adenocarcinoma (2017) (0)
- Mechanism and biological significance of sequential cleavages of CD44 - A potential molecular target for cancer therapy (2004) (0)
- Spatial heterogeneity of invading glioblastoma cells regulated by paracrine factors. (2021) (0)
- Abstract 3135: Benzaldehyde suppresses the binding activity of overexpressed 14-3-3ζ to multiple signaling proteins in cancer cells (2017) (0)
- Abstract 2019: Drug repositioning to induce the synthetic lethality in cancer cells with GSH-depleting therapy (2021) (0)
- Establishment and Characterization of Mouse Osteosarcoma Stem Cells (2012) (0)
- STMC-17. N-CADHERIN UPREGULATION MEDIATES SLOW PROLIFERATION AND THERAPEUTIC RESISTANCE IN GLIOMA STEM CELLS (2016) (0)
- Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models (2021) (0)
- Abstract 562: The Hippo pathway component LATS1 phosphorylates MYPT1 to counteract PLK1 and regulate G2 DNA damage checkpoint. (2013) (0)
- Mouse mammary gland reconstitution with extrinsic gene-transferred mammary epithelial cells in vitro and in vivo (2008) (0)
- Proteome profiling reveals gender differences in the composition of human serum (2010) (0)
- Abstract 1579: Establishment of transgenic medaka as a stable tumor model forin vivoscreening of anticancer drugs. (2013) (0)
- [Implication of cell cycle regulating genes in carcinogenesis]. (1995) (0)
- Estimating copy number to determine BRCA2 deletion status and to expect prognosis in localized prostate cancer (2023) (0)
- A microfluidic invasion assay for glioma-initiating cells in three-dimensional culture (2013) (0)
- Analysis of disease on the central nervous system by proteomic approaches (2003) (0)
- T cell receptor α and β gene sequencing of human melanoma-specific cytotoxic T lymphocytes: 74 (1993) (0)
- Development of a New Mouse Model for Mature B Cell Lymphoma and Resistance to Fas Restoration-Triggered Apoptosis (2016) (0)
- Intratumoral heterogeneity of HER2 expression is relevant to breast cancer malignancy (2016) (0)
- Targeting Cancer Stem Cells-Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism (2014) (0)
- MECHANISMS OF ADAPTIVE RADIOPROTECTION IN GLIOMA STEM CELLS (2014) (0)
- Abstract 1531: Therapeutic strategies for osteosarcoma stem cells by regulating adipocyte differentiation based on actin dynamics (2017) (0)
- Derepression of GATA factor-mediated repression releases erythropoietin in non-canonical erythropoietin producing cells (2015) (0)
- [Current clinical trials using new targeted therapies for myeloid leukemia and the research trends]. (2009) (0)
- Development of novel strategies to overcome therapeutic resistant cancers (2022) (0)
- Blockade of the mevalonate pathway increases CD9 and CD81. (2013) (0)
- Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma (2020) (0)
- CBMS-05 Biological and Pathological meaning of aneuploidy in mouse glioma stem sell (2020) (0)
- P4-03-04: Identification of Molecular Targets for Cancer-Initiating Cells Using a Triple-Negative Breast Cancer Mouse Model. (2011) (0)
- 2.Checkpoint abnormalities in brain tumor cells and molecular targets for treatments (2003) (0)
- Supplementary Figure Legends (2013) (0)
- Abstract 4083: Intrahepatic cholangiocarcinoma and gallbladder carcinoma mouse model based on transplantation of syngeneic tumor-initiating cells (2018) (0)
- Abstract 487: Invasion characteristics of tumor cells in a glioblastoma model of genetically modified neural stem cells (2012) (0)
- Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma (2022) (0)
- Abstract 4255: EpCAM positive lung cells are involved in organoid formation (2016) (0)
- ET-1 STEM CELL-BASED GENE THERAPY FOR MALIGNANT GLIOMA USING GENOME-EDITED HUMAN INDUCED PLURIPOTENT STEM CELLS (2022) (0)
- Antitumor Activity of KW-2450 against Triple- NegativeBreastCancerbyInhibitingAuroraAand (2015) (0)
- Abstract 4436: Chronic inflammation and gastric carcinogenesis: the role of CD44 variant expression (2012) (0)
- Tumor Necrosis Factor- Promotes Epithelial-Mesenchymal Transition Through Hyaluronan-CD44-ERM Interaction in Human Retinal Pigment Epithelial Cells (2008) (0)
- Development of treatment for Pelizaeus-Merzbacher disease: Drug-repositioning approach targeting a novel cellular pathology (2017) (0)
- Abstract 3579: Pimozide combined with paclitaxel demonstrates a significant antitumor effect in head and neck squamous cell carcinoma (2020) (0)
- Detection of Binding Proteins of Merlin, the NF2 Tumor Suppressor Gene Product (1996) (0)
- MP39-14 METFORMIN IS A NEW THERAPEUTIC STRATEGY FOR TARGETING CD44 VARIANT IN BLADDER CANCER (2014) (0)
- Imprinted regulation in the region of Prader-Willi and Angelman syndromes (1996) (0)
- Microsoft Word-Atsumi-etal(JBC)-2ndRevRev.docx (2013) (0)
- Biological aspects of the neurofibromatosis type 2 gene product (1999) (0)
- Hepatocellular Carcinoma and Is Associated with Poor Prognosis in Patients with Mediated Mesenchymal Phenotype − β CD 44 s Regulates the TGF-Updated (2012) (0)
- What can metabolites tell us about gliomas? (2022) (0)
- Abstract 4086: Critical roles of FRS2beta, a feedback inhibitor of ErbB-ERK signaling, for communication between cancer stem cells and their niche during mammary tumorigenesis (2016) (0)
- Abstract 4639: SLC7A11 expression confers cancer stem-like properties in small cell lung cancer cells (2019) (0)
- Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2022) (0)
- CBIO-12. GTP METABOLIC SWITCH LEADS TO NUCLEOLAR TRANSFORMATION AND MALIGNANT GROWTH OF GLIOBLASTOMA (2017) (0)
- Differential Expression of FGF Receptor-1 and FGF Receptor-2 Is Associated with Malignant Progression of Gliomas (1996) (0)
- 1633PEFFECT OF HER2 OVEREXPRESSION ON CANCER STEM-LIKE CHARACTERISTICS OF TRIPLE-NEGATIVE BREAST CANCER CELLS. (2014) (0)
- [Neurosurgery and molecular biology: (series 1) basic knowledge for understanding molecular biology of the cell]. (1998) (0)
- Diagnosis of Leishmania species from formalin-fixed biopsy samples of ecuadorian patients by PCR (1998) (0)
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What Schools Are Affiliated With Hideyuki Saya?
Hideyuki Saya is affiliated with the following schools:
