Hiroaki Suga
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Japanese chemistry professor
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Hiroaki Sugachemistry Degrees
Chemistry
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#1093
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Organic Chemistry
#116
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#152
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Chemistry
Hiroaki Suga's Degrees
- PhD Chemistry Kyoto University
Why Is Hiroaki Suga Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hiroaki Suga is a Japanese biochemist and businessman. He is best known for his work on artificial ribozymes and their application in mRNA display . Suga was awarded the 2023 Wolf Prize in Chemistry, jointly with Chuan He and Jeffery W. Kelly, "for pioneering discoveries that illuminate the functions and pathological dysfunctions of RNA and proteins and for creating strategies to harness the capabilities of these biopolymers in new ways to ameliorate human diseases."
Hiroaki Suga's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A highly flexible tRNA acylation method for non-natural polypeptide synthesis (2006) (324)
- Flexizymes for genetic code reprogramming (2011) (290)
- Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs. (2003) (285)
- Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges. (2019) (262)
- Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library. (2011) (236)
- Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer. (2003) (224)
- Quorum sensing and the LysR‐type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae (2004) (214)
- Structural basis for the drug extrusion mechanism by a MATE multidrug transporter (2013) (212)
- Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides. (2008) (196)
- Ribozyme-catalyzed tRNA aminoacylation (2000) (163)
- Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog (2014) (150)
- Selection-based discovery of druglike macrocyclic peptides. (2014) (149)
- Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides. (2008) (147)
- Molecular mechanisms of bacterial quorum sensing as a new drug target. (2003) (145)
- Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2. (2012) (126)
- Synthesis of polyester by means of genetic code reprogramming. (2007) (125)
- Diverse backbone-cyclized peptides via codon reprogramming. (2009) (123)
- An in vitro evolved precursor tRNA with aminoacylation activity (2001) (122)
- Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae (2007) (120)
- Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme (2008) (120)
- Ribosomal production and in vitro selection of natural product-like peptidomimetics: the FIT and RaPID systems. (2012) (114)
- In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors. (2012) (109)
- Reevaluation of the D-amino acid compatibility with the elongation event in translation. (2013) (106)
- Initiating translation with D-amino acids. (2008) (104)
- An alcohol dehydrogenase ribozyme (2003) (99)
- Ribosomal synthesis of bicyclic peptides via two orthogonal inter-side-chain reactions. (2008) (99)
- RNA Display Methods for the Discovery of Bioactive Macrocycles. (2019) (98)
- Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids. (2008) (97)
- Highly selective inhibition of histone demethylases by de novo macrocyclic peptides (2017) (97)
- Ribosomal Synthesis of Peptides with Multiple β-Amino Acids. (2016) (94)
- Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase (2011) (92)
- A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets. (2017) (92)
- The flexizyme system: a highly flexible tRNA aminoacylation tool for the translation apparatus. (2007) (91)
- A versatile tRNA aminoacylation catalyst based on RNA. (2003) (87)
- Activation of the phz Operon of Pseudomonas fluorescens 2-79 Requires the LuxR Homolog PhzR, N-(3-OH-Hexanoyl)-l-Homoserine Lactone Produced by the LuxI Homolog PhzI, and a cis-Acting phz Box (2005) (85)
- Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity (2014) (84)
- Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump (2007) (83)
- Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes. (2016) (83)
- Consecutive Elongation of D-Amino Acids in Translation. (2017) (83)
- Translation initiation with initiator tRNA charged with exotic peptides. (2009) (80)
- Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change. (2014) (77)
- Artificial human Met agonists based on macrocycle scaffolds (2015) (75)
- One-pot synthesis of azoline-containing peptides in a cell-free translation system integrated with a posttranslational cyclodehydratase. (2014) (74)
- Ribosomal synthesis of peptidase-resistant peptides closed by a nonreducible inter-side-chain bond. (2008) (71)
- Reduction of an aldehyde by a NADH/Zn2+ -dependent redox active ribozyme. (2004) (68)
- ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) (68)
- Using a solid-phase ribozyme aminoacylation system to reprogram the genetic code. (2003) (66)
- Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide. (2016) (60)
- A flexizyme that selectively charges amino acids activated by a water-friendly leaving group. (2009) (60)
- Ribosomal Incorporation of Consecutive β-Amino Acids. (2018) (59)
- Flexizymes: their evolutionary history and the origin of catalytic function. (2011) (59)
- Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids (2018) (59)
- Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies. (2015) (57)
- Unusual metal ion catalysis in an acyl-transferase ribozyme. (1998) (57)
- Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo (2017) (55)
- Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation (2017) (55)
- Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads. (2017) (54)
- Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum (2011) (54)
- Essential structural elements in tRNAPro for EF-P-mediated alleviation of translation stalling (2016) (54)
- An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center. (2014) (53)
- GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf (2020) (52)
- In vitro selection of multiple libraries created by genetic code reprogramming to discover macrocyclic peptides that antagonize VEGFR2 activity in living cells. (2013) (51)
- Synthesis of biopolymers using genetic code reprogramming. (2008) (50)
- De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease. (2019) (50)
- A tRNA aminoacylation system for non-natural amino acids based on a programmable ribozyme (2002) (50)
- Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides. (2009) (49)
- N-(3-Hydroxyhexanoyl)-l-Homoserine Lactone Is the Biologically Relevant Quormone That Regulates the phz Operon of Pseudomonas chlororaphis Strain 30-84 (2007) (49)
- Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids (2020) (48)
- Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor (2019) (48)
- Ribosomal Synthesis of Cyclic Peptides with a Fluorogenic Oxidative Coupling Reaction (2009) (46)
- Ribosomal Synthesis of Backbone‐Macrocyclic Peptides Containing γ‐Amino Acids (2011) (46)
- Structural and kinetic characterization of an acyl transferase ribozyme. (1998) (45)
- De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry. (2018) (44)
- Concurrent molecular recognition of the amino acid and tRNA by a ribozyme. (2001) (44)
- Strategies for transitioning macrocyclic peptides to cell-permeable drug leads. (2017) (43)
- Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides. (2019) (42)
- Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides (2013) (42)
- De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains (2019) (42)
- A Macrocyclic Peptide that Serves as a Cocrystallization Ligand and Inhibits the Function of a MATE Family Transporter (2013) (41)
- A ribozyme exclusively aminoacylates the 3'-hydroxyl group of the tRNA terminal adenosine. (2001) (41)
- Selection-based discovery of macrocyclic peptides for the next generation therapeutics. (2015) (41)
- Polymerization of α‐Hydroxy Acids by Ribosomes (2008) (38)
- Vicinal bromofluoroalkanes their regioselective formation and their conversion to fluoroolefins (1990) (38)
- Flexizyme-mediated genetic reprogramming as a tool for noncanonical peptide synthesis and drug discovery. (2013) (38)
- Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation. (2012) (38)
- Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides. (2017) (37)
- Nonproteinogenic deep mutational scanning of linear and cyclic peptides (2018) (37)
- Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases (2017) (37)
- Ribosomal Elongation of Cyclic γ-Amino Acids using a Reprogrammed Genetic Code. (2020) (36)
- Ribosomal Synthesis of Backbone-Cyclic Peptides Compatible with In Vitro Display. (2019) (36)
- Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming. (2015) (36)
- Designer ribozymes: programming the tRNA specificity into flexizyme. (2004) (35)
- Expression of histone H3 tails with combinatorial lysine modifications under the reprogrammed genetic code for the investigation on epigenetic markers. (2008) (33)
- Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis (2017) (33)
- Ribosome-mediated synthesis of natural product-like peptides via cell-free translation. (2016) (32)
- Minimal lactazole scaffold for in vitro thiopeptide bioengineering (2020) (32)
- Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation (2015) (32)
- Regioselective formation of fluorohydrins and their stereoselective conversion to fluoroolefins (1990) (32)
- Stereoisomers of P. aeruginosa autoinducer analog to probe the regulator binding site. (2006) (31)
- Ribosomal synthesis of an amphotericin-B inspired macrocycle. (2014) (30)
- Bases in the anticodon loop of tRNAAlaGGC prevent misreading (2009) (30)
- Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation (2013) (29)
- Ribosomal synthesis of backbone macrocyclic peptides. (2011) (29)
- Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5. (2017) (28)
- Implementation of a transhydrogenase-like shunt to counter redox imbalance during xylose fermentation in Saccharomyces cerevisiae (2013) (28)
- Display Selection of Exotic Macrocyclic Peptides Expressed under a Radically Reprogrammed 23 Amino Acid Genetic Code. (2018) (28)
- Reprogramming the genetic code in vitro. (2014) (27)
- Synthesis of fused tricyclic peptides using a reprogrammed translation system and chemical modification. (2015) (27)
- Recent Developments of Engineered Translational Machineries for the Incorporation of Non-Canonical Amino Acids into Polypeptides (2015) (27)
- A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM (2015) (27)
- Esterolytic antibodies induced to haptens with a 1,2-amino alcohol functionality (1994) (26)
- Aminoacyl-tRNA synthesis by a resin-immobilized ribozyme. (2002) (26)
- Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming. (2020) (26)
- Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy. (2020) (26)
- Catalytic antibodies generated via heterologous immunization (1994) (25)
- A minihelix-loop RNA acts as a trans-aminoacylation catalyst. (2001) (25)
- The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides. (2021) (25)
- Energetics of side-chain snorkeling in transmembrane helices probed by nonproteinogenic amino acids (2016) (25)
- The nature of the electronic excitations capturing centres in the DNA (2006) (24)
- Outersphere and innersphere coordinated metal ions in an aminoacyl-tRNA synthetase ribozyme. (2002) (24)
- Ribosomal synthesis of nonstandard peptides. (2008) (24)
- Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets (2014) (24)
- Ribosomal Synthesis of Peptides with C‐Terminal Lactams, Thiolactones, and Alkylamides (2009) (24)
- De novo carborane-containing macrocyclic peptides targeting human EGFR. (2019) (23)
- The RNA origin of transfer RNA aminoacylation and beyond (2011) (22)
- Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies (2020) (21)
- Ribosomal Formation of Thioamide Bond in Polypeptide Synthesis. (2019) (21)
- GLYCOSIDASE ANTIBODIES INDUCED TO A HALF-CHAIR TRANSITION-STATE ANALOG (1994) (21)
- Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting. (2017) (20)
- Engineering of RiPP pathways for the production of artificial peptides bearing various non-proteinogenic structures. (2018) (20)
- Programmable ribozymes for mischarging tRNA with nonnatural amino acids and their applications to translation. (2005) (20)
- Ribosomal Elongation of Aminobenzoic Acid Derivatives. (2020) (19)
- Exploring the Post-Translational Enzymology of PaaA by mRNA Display. (2020) (19)
- Electronic Excitation Energy Transfer in DNA. Nature of Triplet Excitations Capturing Centers (2007) (19)
- Flexizyme as a versatile tRNA acylation catalyst and the application for translation. (2006) (19)
- Diverse roles of metal ions in acyl-transferase ribozymes. (2001) (18)
- Synthesis of the backbone cyclic peptide sunflower trypsin inhibitor-1 promoted by the induced peptidyl-tRNA drop-off. (2011) (18)
- Leucyl/Phenylalanyl‐tRNA‐Protein Transferase‐Mediated Chemoenzymatic Coupling of N‐Terminal Arg/Lys Units in Post‐translationally Processed Proteins with Non‐natural Amino Acids (2006) (18)
- A single metal ion plays structural and chemical roles in an aminoacyl-transferase ribozyme. (2001) (18)
- Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation. (2019) (17)
- An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch (2020) (17)
- Catalytic Antibodies Generated via Homologous and Heterologous Immunization (1995) (17)
- Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers. (2012) (17)
- Flexizymes as a tRNA acylation tool facilitating genetic code reprogramming. (2012) (17)
- Promiscuous enzymes cooperate at the substrate level en route to lactazole A. (2020) (16)
- Ancestral AlaX Editing Enzymes for Control of Genetic Code Fidelity Are Not tRNA-specific* (2015) (16)
- DNA module platform for developing colorimetric aptamer sensors. (2016) (15)
- Flexizymes-facilitated Genetic Code Reprogramming Leading to the Discovery of Drug-like Peptides (2014) (15)
- Structural analysis of the water-soluble carbohydrate from Asaia bogorensis by NMR spectroscopy (2007) (15)
- Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A. (2018) (14)
- Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation. (2019) (14)
- Protein cocrystallization molecules originating from in vitro selected macrocyclic peptides. (2014) (14)
- Functional properties of synthetic N-acyl-L-homoserine lactone analogs of quorum-sensing gram-negative bacteria on the growth of human oral squamous carcinoma cells (2012) (13)
- Engineering Translation Components Improve Incorporation of Exotic Amino Acids (2019) (13)
- Conformational and chemical selection by a trans-acting editing domain (2017) (13)
- In vivo targeting of c-Met using a non-standard macrocyclic peptide in gastric carcinoma. (2017) (13)
- Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages (2020) (13)
- In vitro expression of genetically encoded non-standard peptides consisting of exotic amino acid building blocks. (2019) (13)
- Discovery of Functional Macrocyclic Peptides by Means of the RaPID System. (2019) (13)
- Recognition of tRNA backbone for aminoacylation with cysteine: evolution from Escherichia coli to human. (2002) (13)
- Genetic code expansion via integration of redundant amino acid assignment by finely tuning tRNA pools. (2018) (13)
- Model foldamers: applications and structures of stable macrocyclic peptides identified using in vitro selection (2015) (12)
- tRNA engineering for manipulating genetic code (2018) (12)
- A novel therapeutic approach for genetic diseases by introduction of suppressor tRNA. (2006) (12)
- Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides† †Electronic supplementary information (ESI) available: Primer sequences, additional MALDI-TOF-MS spectra, TIC traces for LC-ESI-MS, and supplementary results on compatibility as noted in the text. See DOI: 10.10 (2016) (12)
- Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans (2014) (12)
- Minihelix-loop RNAs: minimal structures for aminoacylation catalysts. (2002) (12)
- α-Fluoro- and α,α-difluoroalkanals by substitution of vicinal bromofluoroalkanes and subsequent pummerer rearrangement (1990) (12)
- Improved stability of siRNA-loaded lipid nanoparticles prepared with a PEG-monoacyl fatty acid facilitates ligand-mediated siRNA delivery. (2020) (12)
- Flexizymes, their evolutionary history and diverse utilities. (2014) (12)
- Discovering Functional, Non-proteinogenic Amino Acid Containing, Peptides Using Genetic Code Reprogramming (2015) (11)
- Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist (2018) (11)
- Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins (2020) (11)
- Genetic Code Expansion by Degeneracy Reprogramming of Arginyl Codons (2016) (11)
- Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation (2020) (11)
- Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models (2021) (11)
- Electrooxidative initiation of tin hydride-promoted radical chain reactions (1992) (10)
- Novel acridine-based N-acyl-homoserine lactone analogs induce endoreduplication in the human oral squamous carcinoma cell line SAS. (2012) (10)
- Essential roles of innersphere metal ions for the formation of the glutamine binding site in a bifunctional ribozyme. (2001) (10)
- Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid α-aminobutyrate (2018) (10)
- Structural Features and Binding Modes of Thioether-Cyclized Peptide Ligands (2018) (10)
- Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display. (2021) (10)
- In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides (2020) (10)
- Identification of nonstandard macrocyclic peptide ligands through display screening. (2017) (10)
- A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX (2016) (10)
- In Vitro Biosynthesis of Peptides Containing Exotic Azoline Analogues (2020) (10)
- Translation initiation by using various N-acylaminoacyl tRNAs. (2006) (10)
- A Post-translational Cyclodehydratase, PatD, Tolerates Sequence Variation in the C-terminal Region of Substrate Peptides (2016) (9)
- Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution (2014) (9)
- Advances in in vitro genetic code reprogramming in 2014–2017 (2018) (9)
- Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC. (2020) (9)
- Uniform affinity-tuning of N-methyl-aminoacyl-tRNAs to EF-Tu enhances their multiple incorporation (2021) (9)
- ELECTROGENERATION OF TRIPHENYLTIN RADICAL, ANION, AND CATION. ELECTROCHEMICAL INITIATION OF TIN HYDRIDE-PROMOTED RADICAL CHAIN REACTIONS (1996) (9)
- Accurate Broadcasting of Substrate Fitness for Lactazole Biosynthetic Pathway from Reactivity-Profiling mRNA Display. (2020) (9)
- Pyrrole-Mediated Peptide Cyclization Identified through Genetically Reprogrammed Peptide Synthesis (2018) (9)
- Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor (2015) (9)
- Max‐Bergmann award lecture:A RaPID way to discover bioactive nonstandard peptides assisted by the flexizyme and FIT systems (2018) (9)
- Artificial In Vitro Biosynthesis Systems for the Development of Pseudo-Natural Products (2018) (9)
- Nonstandard peptide expression under the genetic code consisting of reprogrammed dual sense codons. (2013) (9)
- Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display. (2020) (9)
- Facile Synthesis of Dimeric Thioether-Macrocyclic Peptides with Antibody-like Affinity against Plexin-B1. (2018) (8)
- Chemoenzymatic posttranslational modification reactions for the synthesis of Ψ[CH2NH]-containing peptides. (2020) (8)
- Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity (2018) (8)
- Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs (2019) (8)
- Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-linked Diubiquitin by a Twofold Strategy. (2020) (8)
- Comparative evaluation of two cell-free protein synthesis systems derived from Escherichia coli for genetic code reprogramming. (2013) (8)
- Ribosome evolution for two artificial amino acids in E. coli. (2010) (8)
- A macrocyclic peptide library with a structurally constrained cyclopropane-containing building block leads to thiol-independent inhibitors of phosphoglycerate mutase. (2020) (7)
- An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold. (2021) (7)
- Consecutive Ribosomal Incorporation of α-Aminoxy/α-Hydrazino Acids with l/d-Configurations into Nascent Peptide Chains. (2021) (7)
- Cyclic Peptide-Based Biologics Regulating HGF-MET (2020) (7)
- Initiating ribosomal peptide synthesis with exotic building blocks. (2020) (7)
- Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562 (2012) (7)
- State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides (2022) (6)
- In Vitro Selection of Macrocyclic d/l-Hybrid Peptides against Human EGFR. (2021) (6)
- Cyclic peptides can engage a single binding pocket through highly divergent modes (2020) (6)
- Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a (2020) (6)
- tRid, an enabling method to isolate previously inaccessible small RNA fractions. (2016) (6)
- Preparation of materials for flexizyme reactions and genetic code reprogramming (2011) (6)
- Posttranslational chemical installation of azoles into translated peptides (2021) (6)
- Mechanistic studies on acyl-transferase ribozymes and beyond. (2004) (5)
- In vitro selection of a 5′-purine ribonucleotide transferase ribozyme (2007) (5)
- Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent HIF-1 Inhibitors and Antitumor Agents. (2020) (5)
- Effects of an autoinducer analogue on antibiotic tolerance in Pseudomonas aeruginosa (2017) (5)
- Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning (2022) (5)
- Programmed Synthesis of Natural Product-like Non-standard Peptides Using the Translation System and Its Application (2010) (5)
- Potent macrocycle inhibitors of the human SAGA deubiquitinating module (2021) (5)
- Translation of a histone H3 tail as a model system for studying peptidyl‐tRNA drop‐off (2011) (5)
- Cell Chemical Biology: Home of Exciting Chemical Biology. (2016) (5)
- MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner (2018) (5)
- Synthetic and Biological Functional Compounds with Direct Excitons Conductivity for Nanoelectronic Devices (2007) (4)
- The Development of a Fluorescence‐Based Competitive Assay Enabled the Discovery of Dimeric Cyclic Peptide Modulators of Ubiquitin Chains (2020) (4)
- Ribosomal Synthesis of Backbone Macrocyclic Peptides (2011) (4)
- Promiscuous enzymes cooperate at the substrate level en route to lactazole A (2020) (4)
- Discovery and Development of Cyclic Peptide Inhibitors of CIB1. (2021) (4)
- De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist (2021) (4)
- De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors (2022) (4)
- Custom synthesis of autoinducers and their analogues. (2011) (4)
- The effect of triplet-triplet excitation energy transfer on the DNA self-protection mechanism (2006) (4)
- Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming. (2021) (4)
- Exploration of incorporation of Nalpha-methylated amino acids into peptides by sense-suppression method. (2007) (4)
- One-Pot In Vitro Ribosomal Synthesis of Macrocyclic Depsipeptides. (2021) (4)
- Ribozymes that use redox cofactors (2004) (4)
- Human trans-editing enzyme displays tRNA acceptor-stem specificity and relaxed amino acid selectivity (2020) (4)
- Chemoenzymatic Posttranslational Modification Reactions for the Synthesis of Ψ[CH 2 NH]‐Containing Peptides (2019) (3)
- In vitro selection of a 5'-purine nucleotide transferase ribozyme. (2007) (3)
- Potent De Novo Macrocyclic Peptides that Inhibit O-GlcNAc Transferase Through an Allosteric Mechanism. (2022) (3)
- A context-dependent and disordered ubiquitin-binding motif (2022) (3)
- Voices of Chemical Biology: Charting the Next Decade. (2016) (3)
- A GTP-state specific cyclic peptide inhibitor of the GTPase Gαs (2020) (3)
- In Vitro Genetic Code Reprogramming for the Expansion of Usable Noncanonical Amino Acids. (2022) (3)
- Artificial Division of Codon Boxes for Expansion of the Amino Acid Repertoire of Ribosomal Polypeptide Synthesis. (2018) (3)
- De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition (2021) (3)
- LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae (2016) (3)
- Catalytic antibodies generated via heterologous immunization. [Erratum to document cited in CA121:80587] (1994) (3)
- In Vitro Selection of Foldamer-Like Macrocyclic Peptides Containing 2-Aminobenzoic Acid and 3-Aminothiophene-2-Carboxylic Acid. (2022) (3)
- Exploring the Minimal RNA Substrate of Flexizymes (2019) (3)
- Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains. (2021) (3)
- Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes (2019) (2)
- De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex (2020) (2)
- Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1. (2019) (2)
- Metal ion requirements in artificial ribozymes that catalyze aminoacylation and redox reactions. (2011) (2)
- De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function. (2022) (2)
- Development of Bioactive Foldamers Using Ribosomally Synthesized Nonstandard Peptide Libraries (2021) (2)
- Solid-Phase-Based Synthesis of Lactazole-Like Thiopeptides. (2022) (2)
- A Pseudomonas aeruginosa Quorum-Sensing autoinducer analog enhances the activity of antibiotics against resistant strains. (2017) (2)
- In situ generation of aminoacyl-tRNAs assisted by ribozymes in translation apparatus. (2007) (2)
- Targeting of extracellular protein-protein interactions with macrocyclic peptides. (2021) (2)
- LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates (2022) (2)
- Drop-off-reinitiation triggered by EF-G-driven mistranslocation and its alleviation by EF-P (2022) (2)
- Corrigendum to A flexizyme that selectively charges amino acids activated by a water-friendly leaving group [Bioorg. Med. Chem. Lett. 19 (2009) 3892] (2010) (1)
- In vitro evolution of flexizymes that function under the conditions in translation system. (2006) (1)
- Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions (2022) (1)
- A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display (2019) (1)
- Ribosomal incorporation of negatively charged d-α- and N-methyl-l-α-amino acids enhanced by EF-Sep (2023) (1)
- [Ribosomal synthesis of nonstandard cyclic peptides and its application to drug discovery]. (2010) (1)
- Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump (cid:1) (2007) (1)
- Regioselective Formation of Fluorohydrins and Their Stereoselective Conversion to Fluoroolefins. (1990) (1)
- In Vitro Selection of Thioether-Closed Macrocyclic Peptide Ligands by Means of the RaPID System. (2022) (1)
- Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases (2021) (1)
- Drug discovery of non-standard peptide with genetic code reprogramming (2011) (1)
- Minimal lactazole scaffold for in vitro production of pseudo-natural thiopeptides (2019) (1)
- Development of Flexizyme Aminoacylation Ribozymes and Their Applications (2021) (1)
- [Artificial ribozymes: selection and application for nonnatural amino acid mutagenesis]. (2003) (1)
- Macrocyclic Peptide-Conjugated Tip for Fast and Selective Molecular Recognition Imaging by High-Speed Atomic Force Microscopy. (2021) (1)
- A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation (2023) (1)
- Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases. (2022) (1)
- Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors. (2018) (1)
- Reengineering aninvitroevolved ribozyme. (2007) (1)
- [Quorum sensing in Pseudomonas aeruginosa: cell to-cell communication to sense the cell density of the same species]. (2003) (1)
- Carcinomas Cell Imaging by Using EpCAM-binding Peptides Selected from the Cyclic Non-standard Peptide Library (2011) (1)
- Phosphine addition to dehydroalanine for peptide modification. (2022) (1)
- Engineering of the Redox Ribozyme for the Determination of Its Architecture (2010) (1)
- Publisher Correction: Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids (2018) (1)
- Correction: In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides (2021) (1)
- poration of carbohydrates into in vitro displayed macrocyclic peptides † (2017) (1)
- Author response: De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition (2021) (0)
- Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue (2022) (0)
- Ribosomal Synthesis of Cyclic Peptides Composed of non-Proteinogenic Amino Acids (2008) (0)
- Chemical peptide macrolactonization via intramolecular S‐to‐S‐to‐O acyl transfer (2022) (0)
- Front Cover: Exploring the Minimal RNA Substrate of Flexizymes (ChemBioChem 15/2019) (2019) (0)
- Ribosomal Synthesis of Peptides Containing Various Unusual Structures and Its Application to the Synthesis of Cyclic Peptides (2008) (0)
- Faculty Opinions recommendation of Antibody-like proteins that capture and neutralize SARS-CoV-2. (0)
- Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation (2019) (0)
- Faculty Opinions recommendation of Foldamer-templated catalysis of macrocycle formation. (2020) (0)
- Author Correction: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter (2020) (0)
- Inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex through the novel macrocyclic peptides (2021) (0)
- Organic Synthesis, Think Differently! (2018) (0)
- A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM (2015) (0)
- [Reprogramming the genetic code using flexizyme]. (2007) (0)
- Chapter 5:In vitro synthetic biology of the genetic code: its development and applications (2014) (0)
- [Expansion and reprogramming of genetic code by Flexizyme]. (2006) (0)
- Mid-Sized Macrocyclic Peptides as a New Drug Modality (2021) (0)
- Cover Picture: Ribosomal Synthesis of Backbone-Macrocyclic Peptides Containing γ-Amino Acids (ChemBioChem 8/2011) (2011) (0)
- Revolutionary therapeutic peptides (2020) (0)
- Two-Chain Mature Hepatocyte Growth Factor-Specific Positron Emission Tomography Imaging in Tumors Using 64Cu-Labeled HiP-8, a Nonstandard Macrocyclic Peptide Probe. (2023) (0)
- 1C1436 Exploring cyclic peptide inhibitors against the Akt2 kinase by the RaPID system and evaluation of their biochemical properties(Proteins: Measurement, Analysis, Engineering,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan) (2012) (0)
- 2.10A resolution structure of independent Phosphoglycerate mutase from C. elegans in complex with a macrocyclic peptide inhibitor (Ce-2 Y7F) (0)
- Simple, though efficient procedures for the introduction of fluorine into a unsaturated hydrocarbons (1991) (0)
- RaPID Selection of Bcl-2 Inhibitors from an Alpha-helix Non-Standard Peptide Library Assisted by an Intramolecular Bridge (2011) (0)
- Flexizymes that enable to reprogram the genetic code (2010) (0)
- An investigation toward a peptide that selectively senses membranes containing poly-unsaturated fatty acyl chains (2016) (0)
- Discovery, biochemical characterization, and bioengineering of cyanobactin prenyltransferases. (2022) (0)
- LimF is a versatile prenyltransferase catalyzing histidine-C-geranylation on diverse nonnatural substrates (2021) (0)
- Correction to "Display Selection of Exotic Macrocyclic Peptides Expressed Under a Radically Reprogrammed 23 Amino Acid Genetic Code". (2019) (0)
- Inside Cover: Genetic Code Expansion by Degeneracy Reprogramming of Arginyl Codons (ChemBioChem 13/2016) (2016) (0)
- FXIIa-cMCoFx1 complex (2021) (0)
- A Novel Method for Modification and Cyclization of Peptides Using an Oxidative Coupling Reaction (2008) (0)
- Site-specific nonenzymatic peptide S/O–glutamylation (2021) (0)
- The exploration of the cyclic peptides that can inhibit the activity of Akt2 protein (2011) (0)
- Ribosomal Synthesis of Histone H3 Tails with Complex Lysine Modifications (2009) (0)
- Crystal structure of K-Ras(G12D) GppNHp bound to cyclic peptide ligand KD2 (2020) (0)
- Corrigendum to "Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A" [Bioorg. Med. Chem. 26/6 (2018) 1225-1231]. (2019) (0)
- 1SE1040 Genetic Code Reprogramming(1SE Recent Advances in Structural Analyses of Funcitonal Mechanisms Based on Dynamics of Biological Reactions,The 48th Annual Meeting of the Biophysical Society of Japan) (2010) (0)
- Crystal structure of an inward-facing eukaryotic ABC multidrug transporter G277V/A278V/A279V mutant in complex with an cyclic peptide inhibitor, aCAP (2014) (0)
- Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: penetration speed of cyclosporin A across lipid bilayers (2022) (0)
- 1.80A resolution structure of independent Phosphoglycerate mutase from C. elegans in complex with a macrocyclic peptide inhibitor (Ce-1 NHOH) (0)
- [In Vitro Selected Macrocyclic Peptides: Tools for Regulating the Conformational Freedom of Transmembrane Proteins]. (2016) (0)
- Genetic Code Reprogramming (2012) (0)
- Ribosomal synthesis of helical peptide libraries containing cyclic β-amino acids and its application to drug screening (2021) (0)
- Structural basis of tRNAPro acceptor stem recognition by a bacterial trans-editing domain. (2023) (0)
- Aminoacyl-tRNA synthetase ribozyme (2008) (0)
- Post-translational Chemical Construction of Backbone-thioester for DNA-programmed Synthesis of Backbone-cyclized Non-natural Peptides (2009) (0)
- Ribosomal Incorporation of Various N^α-Methylated Amino Acids into a Peptide Backbone (2008) (0)
- Front cover. (2017) (0)
- From Powerful Review Articles to Research Breakthroughs. (2016) (0)
- Ribosomal Synthesis of Peptides Having Various Acyl Groups on the N-Terminus (2007) (0)
- Drop-off-reinitiation at the amino termini of nascent peptides and its regulation by IF3, EF-G, and RRF (2023) (0)
- Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins (2022) (0)
- Effects of Chemical Substance Associated with Quorum Sensing on Porphyromonas gingivalis biofilm (2006) (0)
- Corrigendum to “Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A” (Bioorganic & Medicinal Chemistry (2018) 26(6) (1225–1231), (S0968089617318497) (10.1016/j.bmc.2018.01.013)) (2019) (0)
- Peptide Cyclization Methodologies Amenable to in Vitro Display (2021) (0)
- Implementation of a transhydrogenase-like shunt to counter redox imbalance during xylose fermentation in Saccharomyces cerevisiae (2012) (0)
- Faculty Opinions recommendation of Genome Mining Reveals High Topological Diversity of ω-Ester-Containing Peptides and Divergent Evolution of ATP-Grasp Macrocyclases. (2020) (0)
- Faculty Opinions recommendation of Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery. (2021) (0)
- Re-engineering an in-vitro evolved ribozyme. (2007) (0)
- In vitro selection of macrocyclic peptides against human aminoacyl-tRNA synthetase complex-interacting protein -1 (AIMP-1) (2013) (0)
- Crystal structure of the DDX41 DEAD domain in an apo closed form (2016) (0)
- Chapter 7. RaPID Discovery of Macrocyclic Peptide Inhibitors of Protein–Protein Interactions (2020) (0)
- The first year of RSC Chemical Biology – a new journal was born (2021) (0)
- Minimal lactazole scaffold for in vitro thiopeptide bioengineering (2020) (0)
- Discovery of Cyclic Peptides Binding to a Cyclophilin Powered by the RaPID System (2011) (0)
- Ribosomal Synthesis of C-Terminally Modified Peptides (2009) (0)
- The Explorement of the Specificity of the Akt2 Peptide Inhibitors Selected by a Novel In Vitro Selection Method, RaPID System (2012) (0)
- Artificial evolution of RNA catalysts : Filling a gap between the RNA world and the next world(From Molecules to Life-Like Systems & RNA World, International Symposium on Origins of Life and Astrobiology) (2005) (0)
- 2.45A resolution structure of Apo independent phosphoglycerate mutase from C. elegans (orthorhombic form) (2017) (0)
- Reflecting on the past and looking forward to the future of bridging chemistry and biology. (2014) (0)
- New strategies for genetic code reprogramming ; dual genetic code and artificial division of codon boxes (2011) (0)
- Structural basis for the novel mechanism of drug extrusion by a MATE multidrug transporter (2013) (0)
- Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins (2021) (0)
- Electrooxidative Initiation of Tin Hydride‐Promoted Radical Chain Reactions. (1993) (0)
- Esterolytic Antibodies Induced to Haptens with a 1,2-Amino Alcohol Functionality. (1994) (0)
- Japan-UK Science, Technology & Innovation Symposium 2014 in London Expanding the Protein and Peptide Universe (2014) (0)
- Corrigendum: A highly flexible tRNA acylation method for non-natural polypeptide synthesis (2006) (0)
- Influenza viral hemagglutinin-targeted macrocycles as an antiviral agent (2016) (0)
- Rapid Progress of Structural Life Science and Discovery of Non-traditional Peptide Drug Leads Accelerated by RaPID System (2012) (0)
- Development of Macrocyclic Peptide Inhibitors Targeting Hepatocyte Growth Factor Receptor c-Met (2013) (0)
- News from the Chemistry & Biology editorial team. (2012) (0)
- Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair (2022) (0)
- Molecular Technologies for Pseudo-natural Peptide Synthesis and Discovery of Bioactive Compounds Against Undruggable Targets (2019) (0)
- Ribosomal synthesis of nonnatural biopolymers in microscales (2006) (0)
- Toward Creating Artifical Peptides Binding to HCV Proteins (2011) (0)
- In Vitro Selection of Macrocyclic α/β3-Peptides against Human EGFR. (2022) (0)
- Abstract SY06-02: The nontraditional peptide therapeutics (2012) (0)
- Display Selection of a Hybrid Foldamer-Peptide Macrocycle (2022) (0)
- Homologous Trans‐editing Factors with Broad Substrate Specificity Prevent Global Mistranslation (2019) (0)
- Expansion of Modality: Peptides to Pseudo-Natural Macrocyclic Peptides (2020) (0)
- Our Advisors, Our Ambassadors, Our Editorial Board Members. (2016) (0)
- Faculty Opinions recommendation of Mirror-Image 5S Ribonucleoprotein Complexes. (2020) (0)
- Accelerating the discovery of nonstandard peptide inhibitors against a deacetylase powered by the RaPID display (2011) (0)
- CHAPTER 11:Biological Synthesis and Affinity-based Selection of Small Macrocyclic Peptide Ligands (2017) (0)
- Author Correction: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter (2020) (0)
- Ribosomal Synthesis of Non-Natural Peptide Using the Flexizyme System (2007) (0)
- Exploringthe Post-translational Enzymology of PaaAby mRNA Display (2020) (0)
- X-ray crystallographic analysis of a MATE multidrug transporter from V. cholerae (2014) (0)
- Ribosomal Synthesis of γ-Amino Acid-Containing Cyclic Peptides (2011) (0)
- Selection of cyclic N-methyl peptide inhibitors against human ubiquitin ligase E6AP using RaPID display (2011) (0)
- PLATFORM TECHNOLOGIES FOR THE ARTIFICIAL PSEUDO-NATURAL PRODUCT DISCOVERY (2014) (0)
- Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons (2018) (0)
- P10 Efficacy of a quorum-sensing inhibitor combined with biapenem in a murine model of neutropenic thigh infection with Pseudomonas aeruginosa (2013) (0)
- In Vitro Selection of Cyclic Peptides Closed by an Oxidative Coupling Reaction (2013) (0)
- 1.95A resolution structure of independent phosphoglycerate mutase from C. elegans in complex with a macrocyclic peptide inhibitor (2d) (2017) (0)
- Post-translational backbone-acyl shift yields natural product-like peptides bearing hydroxyhydrocarbon units. (2022) (0)
- A RaPID macrocyclic peptide that inhibits the formation of α‐synuclein amyloid fibrils (2023) (0)
- Vicinal Bromofluoroalkanes: Their Regioselective Formation and Their Conversion to Fluoroolefins. (1990) (0)
- Programmed Synthesis of Natural Product‐Like Non‐Standard Peptides Using the Translation System and Its Application (2010) (0)
- Incorporation of backbone modifications in mRNA-displayable peptides. (2021) (0)
- Faculty Opinions recommendation of Laboratory evolution of virus-like nucleocapsids from nonviral protein cages. (2019) (0)
- α-Fluoro- and α,α-Difluoroalkanals by Substitution of Vicinal Bromofluoroalkanes and Subsequent Pummerer Rearrangement. (1990) (0)
- Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist (2018) (0)
- Abstract SY05-03: Natural product-inspired peptide drug discovery accelerated by the RaPID system (2014) (0)
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