Hiroshi Itoh
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Hiroshi Itohbiology Degrees
Biology
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#19321
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Molecular Biology
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#2679
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Neuroscience
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#2824
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Biochemistry
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#2881
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Biology
Hiroshi Itoh's Degrees
- PhD Biochemistry University of Tokyo
- Bachelors Chemistry University of Tokyo
Why Is Hiroshi Itoh Influential?
(Suggest an Edit or Addition)Hiroshi Itoh's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structure and function of signal-transducing GTP-binding proteins. (1991) (559)
- Isolation and characterization of the human Gs alpha gene. (1988) (331)
- Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. (1986) (265)
- Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (1988) (234)
- SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling (2002) (227)
- Distinct Pathways of Cell Migration and Antiapoptotic Response to Epithelial Injury: Structure-Function Analysis of Human Intestinal Trefoil Factor (2000) (200)
- Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. (1988) (199)
- Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule (2010) (195)
- Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway* (2008) (190)
- Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. (1988) (178)
- Critical Duration of Intracellular Ca2+ Response Required for Continuous Translocation and Activation of Cytosolic Phospholipase A2 * (1999) (172)
- Activation of p38 Mitogen-activated Protein Kinase by Signaling through G Protein-coupled Receptors (1997) (154)
- Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins. (1987) (150)
- Functions and Regulatory Mechanisms of Gq-Signaling Pathways (2009) (143)
- Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Specific Cell Surface Binding Protein of Hepatocyte Growth Factor Activator (HGFA) and Regulates HGFA Activity in the Pericellular Microenvironment* (2000) (130)
- Involvement of Protein Kinase C and Src Family Tyrosine Kinase in Gαq/11-induced Activation of c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase* (1998) (122)
- Activation of the G protein Gq/11 through tyrosine phosphorylation of the α subunit (1997) (120)
- The Src family tyrosine kinase is involved in Rho-dependent activation of c-Jun N-terminal kinase by Gα12 (1999) (81)
- Ras Oncoprotein Induces CD44 Cleavage through Phosphoinositide 3-OH Kinase and the Rho Family of Small G Proteins* (2000) (80)
- Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon‐γ‐induced MAPK activation that is mediated by p21 ras (1997) (76)
- Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. (1991) (74)
- Conversion of adrenergic mechanism from an alpha- to a beta-type during primary culture of rat hepatocytes. Accompanying decreases in the function of the inhibitory guanine nucleotide regulatory component of adenylate cyclase identified as the substrate of islet-activating protein. (1984) (71)
- Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells* (2009) (69)
- Src Kinase Regulates the Activation of a Novel FGD-1-related Cdc42 Guanine Nucleotide Exchange Factor in the Signaling Pathway from the Endothelin A Receptor to JNK* (2003) (66)
- Expression and analysis of Gs alpha mutants with decreased ability to activate adenylylcyclase. (1991) (65)
- LUCA15, a putative tumour suppressor gene encoding an RNA‐binding nuclear protein, is down‐regulated in ras‐transformed Rat‐1 cells (2000) (63)
- CD47 Promotes Neuronal Development through Src- and FRG/Vav2-Mediated Activation of Rac and Cdc42 (2006) (62)
- Regulation of Rac and Cdc42 Pathways by Gi during Lysophosphatidic Acid-induced Cell Spreading* (2001) (61)
- Ric‐8A potentiates Gq‐mediated signal transduction by acting downstream of G protein‐coupled receptor in intact cells (2006) (60)
- The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. (2007) (58)
- Differential Regulation of Mitogen-activated Protein Kinase Kinase 4 (MKK4) and 7 (MKK7) by Signaling from G Protein βγ Subunit in Human Embryonal Kidney 293 Cells* (1999) (57)
- Celecoxib potently inhibits TNFalpha-induced nuclear translocation and activation of NF-kappaB. (2008) (56)
- Ric-8B Stabilizes the α Subunit of Stimulatory G Protein by Inhibiting Its Ubiquitination* (2010) (56)
- Identification of sites for alkylation by N‐ethylmaleimide and pertussis toxin‐catalyzed ADP‐ribosylation on GTP‐binding proteins (1990) (55)
- Bikunin Target Genes in Ovarian Cancer Cells Identified by Microarray Analysis* (2003) (55)
- G protein βγ subunit activates Ras, Raf, and MAP kinase in HEK 293 cells (1995) (54)
- Hamster alpha 1B-adrenergic receptor directly activates Gs in the transfected Chinese hamster ovary cells. (1995) (53)
- Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (1989) (52)
- Gi-dependent Activation of c-Jun N-terminal Kinase in Human Embryonal Kidney 293 Cells* (2000) (50)
- Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling (2002) (50)
- Analysis by mRNA levels of the expression of six G protein alpha-subunit genes in mammalian cells and tissues. (1991) (48)
- Requirement for Protein-tyrosine Phosphatase SHP-2 in Insulin-induced Activation of c-Jun NH2-terminal Kinase* (2000) (47)
- Licochalcone A Potently Inhibits Tumor Necrosis Factor α-Induced Nuclear Factor-κB Activation through the Direct Inhibition of IκB Kinase Complex Activation (2009) (45)
- HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma (2017) (44)
- Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA. (2008) (44)
- Parallel Regulation of Mitogen-activated Protein Kinase Kinase 3 (MKK3) and MKK6 in Gq-signaling Cascade* (2001) (43)
- Betagamma subunits of pertussis toxin-sensitive G proteins mediate A1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin. A novel stimulatory mechanism through the cross-talk of two types of receptors. (1997) (43)
- Identification of three pertussis toxin substrates (41, 40 and 39 kDa proteins) in mammalian brain Comparison of predicted amino acid sequences from G‐protein α‐subunit genes and cDNAs with partial amino acid sequences from purified proteins (1988) (41)
- Phosphorylation of Doublecortin by Protein Kinase A Orchestrates Microtubule and Actin Dynamics to Promote Neuronal Progenitor Cell Migration* (2012) (41)
- The ram: A novel low molecular weight GTP‐binding protein cDNA from a rat megakaryocyte library (1990) (40)
- Cytosolic nuclease activated by caspase-3 and inhibited by DFF-45. (1998) (39)
- Activation of the G protein Gq/11 through tyrosine phosphorylation of the alpha subunit. (1997) (39)
- Calcium phosphate-mediated transfection of primary cultured brain neurons using GFP expression as a marker: application for single neuron electrophysiology (1999) (39)
- G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration. (2005) (39)
- Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein. (1990) (38)
- Identification of lung major GTP-binding protein as Gi2 and its distribution in various rat tissues determined by immunoassay. (1989) (37)
- Endothelin suppresses cell migration via the JNK signaling pathway in a manner dependent upon Src kinase, Rac1, and Cdc42 (2002) (36)
- NESK, a Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Is Expressed during the Late Stages of Embryogenesis* (2000) (36)
- α Helix Content of G Protein α Subunit Is Decreased upon Activation by Receptor Mimetics* (1998) (36)
- Presence of Three Distinct Molecular Species of Gi Protein a Subunit (1988) (35)
- p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5 (2011) (35)
- Gα11 Induces Caspase-mediated Proteolytic Activation of Rho-associated Kinase, ROCK-I, in HeLa Cells* (2001) (34)
- C-terminal Mutation of G Protein β Subunit Affects Differentially Extracellular Signal-regulated Kinase and c-Jun N-terminal Kinase Pathways in Human Embryonal Kidney 293 Cells* (1997) (34)
- [Heterotrimeric G protein]. (2008) (31)
- GTP‐binding proteins in human platelet membranes serving as the specific substrate of islet‐activating protein, pertussis toxin (1988) (30)
- Identification of Cis-elements of the Human Endothelin-A Receptor Gene and Inhibition of the Gene Expression by the Decoy Strategy* (1998) (29)
- G‐protein signalling negatively regulates the stability of aryl hydrocarbon receptor (2009) (28)
- Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5 (2014) (26)
- The Adaptor Protein Nck1 Mediates Endothelin A Receptor-regulated Cell Migration through the Cdc42-dependent c-Jun N-terminal Kinase Pathway* (2004) (25)
- G Protein βγ Subunits Induce Stress Fiber Formation and Focal Adhesion Assembly in a Rho-dependent Manner in HeLa Cells* (2000) (25)
- Expression of an oncogenic mutant Gαi2 activates Ras in Rat‐1 fibroblast cells (1998) (24)
- Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (2003) (24)
- Involvement of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase in α1B-Adrenergic Receptor/Gαq-Induced Inhibition of Cell Proliferation (2001) (24)
- Beta2-adrenergic receptor/cyclic adenosine monophosphate (cAMP) leads to JNK activation through Rho family small GTPases. (2001) (23)
- A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: Implication for Andersen's syndrome (2002) (21)
- Agonistic antibodies reveal the function of GPR56 in human glioma U87-MG cells. (2015) (21)
- κB-Ras Is a Nuclear-Cytoplasmic Small GTPase That Inhibits NF-κB Activation through the Suppression of Transcriptional Activation of p65/RelA* (2010) (21)
- Importance of the G protein γ subunit in activating G protein‐coupled inward rectifier K+ channels (1999) (20)
- Phosphorylation of F-actin-Associating G Protein γ12 Subunit Enhances Fibroblast Motility* (1999) (19)
- Structures of the genes coding for G-protein alpha subunits from mammalian and yeast cells. (1988) (18)
- Regulation of the Golgi structure by the α subunits of heterotrimeric G proteins (2000) (17)
- The mechanism of membrane‐translocation of regulator of G‐protein signaling (RGS) 8 induced by Gα expression (2003) (17)
- RABL2 positively controls localization of GPCRs in mammalian primary cilia (2019) (16)
- Activation of c-fos Promoter by Gβγ-Mediated Signaling: Involvement of Rho and c-Jun N-Terminal Kinase (1999) (16)
- Carboxyl Terminal of G Protein β Subunit Is Required for Association with γ Subunit (1995) (15)
- Inducible high-level expression vector for mammalian cells, pEF-LAC carrying human elongation factor 1alpha promoter and lac operator. (1997) (14)
- Signal transduction mediated through adhesion-GPCRs. (2010) (13)
- Purification and identification of two pertussis-toxin-sensitive GTP-binding proteins of bovine spleen. (1989) (13)
- Galphaq-dependent activation of mitogen-activated protein kinase kinase 4/c-Jun N-terminal kinase cascade. (2001) (12)
- ADP-ribosylation of the inhibitory guanine nucleotide regulatory protein (Ni) as a possible mechanism underlying development of beta-adrenergic responses during primary culture of rat hepatocytes. (1985) (12)
- Differential regulation of mitogen-activated protein kinase kinase 4 (MKK4) and 7 (MKK7) by signaling from G protein beta gamma subunit in human embryonal kidney 293 cells. (1999) (12)
- Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase. (2002) (12)
- Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric‐8B in Gs suppression by Gq signal (2013) (11)
- Thrombin‐induced inhibition of myoblast differentiation is mediated by Gβγ (2000) (10)
- Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein a subunit ( signal transduction / ADP-ribosylation ) (10)
- Involvement of protein kinase C and Src family tyrosine kinase in Galphaq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. (1998) (9)
- Isolation and characterization of the human Gsa gene ( GTP-binding protein / alternative splicing / promoter / adenylate cyclase ) (8)
- G protein betagamma subunits induce stress fiber formation and focal adhesion assembly in a Rho-dependent manner in HeLa cells. (2000) (8)
- Loss of a primary cilium in PDAC (2017) (8)
- G protein beta gamma subunit activates Ras, Raf, and MAP kinase in HEK 293 cells. (1995) (8)
- Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells. (1998) (8)
- CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells (2020) (6)
- HDAC 2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma (2017) (6)
- Activation of c-fos promoter by Gbetagamma-mediated signaling: involvement of Rho and c-Jun N-terminal kinase. (1999) (5)
- CHAPTER 4 – Organization of Genes Coding for G-Protein α Subunits in Higher and Lower Eukaryotes (1990) (4)
- Development of photoresponsive RNA towards photoswitching of RNA functions. (2007) (4)
- βγ Subunits of Pertussis Toxin-sensitive G Proteins Mediate A1 Adenosine Receptor Agonist-induced Activation of Phospholipase C in Collaboration with Thyrotropin (1997) (4)
- Involvement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase in alpha1B-adrenergic receptor/Galphaq-induced inhibition of cell proliferation. (2001) (4)
- Cis Elements for Transcriptional Regulation of the Human Endothelin‐A Receptor Gene (1995) (4)
- Light-dependent activation of G proteins by two isoforms of chicken melanopsins. (2015) (3)
- Regulation of the golgi structure by the alpha subunits of heterotrimeric G proteins. (2000) (3)
- Multiple Transcripts of Human Endothelin‐A Receptor Gene Detected by Reverse Transcription and the Polymerase Chain Reaction (1995) (3)
- Differential display of mRNAs regulated by G-protein signaling. (2002) (2)
- Carboxyl terminal of G protein beta subunit is required for association with gamma subunit. (1995) (2)
- 1P156 Optimization of ADP and Pi concentrations during mechanically driven ATP synthesis by F_1-ATPase (2005) (1)
- Erratum: Gα 11 induces caspase-mediated proteolytic activation of Rho-associated kinase, ROCK-I, in HeLa cells (Journal of Biological Chemistry (2001) 276 (42527-42533)) (2002) (1)
- Cholesterol in the ciliary membrane as a therapeutic target against cancer (2023) (1)
- KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells (2022) (1)
- Trafficking of Serotonin Receptor 5HT6 to Primary Cilia (2016) (0)
- Isolation ofasecond yeast Saccharomyces cerevisiae gene(GPA2) coding forguanine nucleotide-binding regulatory protein: Studies onitsstructure andpossible functions (GTP-binding proteins/signal transduction/ras proteins/gene disruption/cAMP) MASATONAKAFUKU*, TOMOKOOBARA*, KozoKAIBUCHIt, IKUKOMIYAJIMA (1988) (0)
- Molecular cloning and sequence determination of cDNAs for a subunits of the guanine nucleotide-binding proteins (2003) (0)
- Actin Dynamics to Promote Neuronal Kinase A Orchestrates Microtubule and Phosphorylation of Doublecortin by Protein Signal Transduction : (2012) (0)
- A novel type of G protein inhibitor, YM‐254890, acts as a Gq‐specific guanine nucleotide dissociation inhibitor via the switch I region of Galpha subunit (2007) (0)
- GPR56 C‐terminal fragment mediates signal received by N‐terminal fragment of another adhesion GPCR Latrophilin1 in neurons (2022) (0)
- Crystal structure of P domain Q389N mutant from Norovirus Funabashi258 stain in the complex with Lewis-b (2012) (0)
- Heterotrimeric G-Proteins: α, β, and γ Subunits (1993) (0)
- Atypical small GTPase RABL3 interacts with RAB11 to regulate early ciliogenesis in human cells (2022) (0)
- Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890 (2010) (0)
- Analysis of molecular mechanism for Gαs ubiquitination (2015) (0)
- Expression and analysis of human aia-adrenergic receptor by the baculovirus-Sf9 expression system (1996) (0)
- Crystal structure of P domain from Norovirus Funabashi258 stain in the complex with A-antigen (2012) (0)
- Molecular mechanism of loss of primary cilia in pancreatic adenocarcinoma cells (2017) (0)
- Regulation of centriole duplication by G-protein regulator Ric-8A (2016) (0)
- Activation of Statl and subsequent transcription of inducible nitric oxide synthase gene in C 6 glioma cells is independent of interferon-y-induced MAPK activation that is mediated by p 21 ras (2011) (0)
- Molecular cloning andsequence determination ofcDNAsfor asubunits oftheguanine nucleotide-bindi ng proteins Gs,Gi, andGofromratbrain (signal ransduction/C6 glioma cells/ras proteins/transducin) (1986) (0)
- KIF24 controls the clustering of supernumerary centrosomes in pancreatic ductal adenocarcinoma cells (2022) (0)
- Dynamic Mobility of Immunological Cells Expressing S100A8 and S100A9 in vivo: A Variety of Functional Roles of the two Proteins as Regulators in Acute Inflammatory Reaction (2011) (0)
- Crystal structure of P domain from Norovirus Funabashi258 stain in the complex with Lewis-a (2012) (0)
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What Schools Are Affiliated With Hiroshi Itoh?
Hiroshi Itoh is affiliated with the following schools:
