Hiroshi Kasai

Q: What Schools Are Affiliated With Hiroshi Kasai

Hiroshi Kasai is affiliated with the following schools: Nara Institute of Science and Technology, University of Tokyo, Institute of Science Tokyo, Columbia University, Kyoto University

Hiroshi Kasai's AcademicInfluence.com Rankings

Hiroshi Kasai

Computer Science

#4862

World Rank

#5133

Historical Rank

Computational Linguistics

#558

World Rank

#567

Historical Rank

Machine Learning

#1093

World Rank

#1110

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Artificial Intelligence

#1323

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#1348

Historical Rank

computer-science Degrees

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Computer Science

Hiroshi Kasai's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

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Hiroshi Kasai's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. (1992) (1786)
Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. (1997) (1070)
Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. (1984) (926)
Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. (1986) (921)
Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues (1987) (765)
8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. (1991) (616)
Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. (1976) (568)
Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA (1998) (482)
Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa. (1996) (375)
Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. (1987) (353)
Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung. (1997) (301)
Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis. (1994) (284)
Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking. (1996) (260)
Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction (1992) (257)
Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator. (1989) (247)
Action of chlorogenic acid in vegetables and fruits as an inhibitor of 8-hydroxydeoxyguanosine formation in vitro and in a rat carcinogenesis model. (2000) (203)
Cigarette smoking induces formation of 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes. (1990) (190)
The Oxidized Forms of dATP Are Substrates for the Human MutT Homologue, the hMTH1 Protein* (1999) (186)
Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells. (1993) (176)
Life Style and Urinary 8‐Hydroxydeoxyguanosine, a Marker of Oxidative DNA Damage: Effects of Exercise, Working Conditions, Meat Intake, Body Mass Index, and Smoking (2001) (172)
Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. (1975) (171)
Prospective study of 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and the risk of lung cancer. (2006) (168)
BENZO(A)PYRENE-NUCLEIC ACID DERIVATIVE FOUND IN VIVO- STRUCTURE OF A BENZO(A)PYRENETETRAHYDRODIOL EPOXIDE-GUANOSINE ADDUCT (1976) (167)
Protection of DNA damage by dietary restriction. (1992) (159)
Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles. (1999) (153)
Potent Novel Mutagens Produced by Broiling Fish under Normal Conditions (1980) (151)
Hydroxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical-forming agents. (1986) (149)
Chemistry-based studies on oxidative DNA damage: formation, repair, and mutagenesis. (2002) (146)
Formation of 2-Hydroxydeoxyadenosine Triphosphate, an Oxidatively Damaged Nucleotide, and Its Incorporation by DNA Polymerases (1995) (144)
Relationships between perceived workload, stress and oxidative DNA damage (2001) (137)
An endonuclease activity of Escherichia coli that specifically removes 8-hydroxyguanine residues from DNA. (1991) (133)
Metal nanoparticle-induced micronuclei and oxidative DNA damage in mice (2012) (133)
Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase. (1993) (131)
Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. (2013) (129)
Structure of a potent mutagen isolated from fried beef. (1981) (128)
Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives. (1984) (124)
Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urine. (2002) (120)
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. (2001) (120)
Formation of 8-hydroxyguanine residues in DNA by X-irradiation. (1984) (119)
Depressive state relates to female oxidative DNA damage via neutrophil activation. (2003) (116)
Infrequent Mutations of the hOGG1 Gene, That Is Involved in the Excision of 8‐Hydroxyguanine in Damaged DNA, in Human Gastric Cancer (1998) (115)
Detection of potent mutagens, Trp-P-1 and Trp-P-2, in broiled fish. (1980) (114)
Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction. (1979) (113)
Depression and possible cancer risk due to oxidative DNA damage. (2005) (111)
Vitamin E inhibits apoptosis, DNA modification, and cancer incidence induced by iron-mediated peroxidation in Wistar rat kidney. (1997) (109)
Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA. (2000) (108)
Psychosocial Factors as a Potential Trigger of Oxidative DNA Damage in Human Leukocytes (2001) (108)
Letter: The structure of Q* nucleoside isolated from rabbit liver transfer ribonucleic acid. (1976) (105)
Induction of Chromosomal Gene Mutations in Escherichia coli by Direct Incorporation of Oxidatively Damaged Nucleotides (1998) (105)
Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process. (1995) (103)
DNA damage induced by asbestos in the presence of hydrogen peroxide. (1984) (97)
Absolute configuration of a ribonucleic acid adduct formed in vivo by metabolism of benzo[a]pyrene. (1977) (95)
5-Formyldeoxyuridine: a new type of DNA damage induced by ionizing radiation and its mutagenicity to salmonella strain TA102. (1990) (94)
Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos. (2001) (92)
Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine values measured by an ELISA correlated well with measurements by high-performance liquid chromatography with electrochemical detection. (2002) (91)
A new automated method to analyze urinary 8-hydroxydeoxyguanosine by a high-performance liquid chromatography-electrochemical detector system. (2003) (91)
Elevated Level of 8‐Hydroxydeoxyguanosine in DNA of Liver, Kidneys, and Brain of Long‐Evans Cinnamon Rats (1993) (87)
An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA+. (1991) (87)
Structure and chemical synthesis of Me-IQ, a potent mutagen isolated from broiled fish. (1980) (83)
DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modifications. (2010) (82)
Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide. (1986) (82)
Distribution of the modified nucleoside Q and its derivatives in animal and plant transfer RNA's. (1975) (82)
Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion. (1984) (82)
Mutagenicity of methylglyoxal in coffee. (1982) (81)
Occupational and lifestyle factors and urinary 8‐hydroxydeoxyguanosine (2005) (81)
Incorporation of the Guanosine Triphosphate Analogs 8-Oxo-dGTP and 8-NH2-dGTP by Reverse Transcriptases and Mammalian DNA Polymerases* (1997) (80)
8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity. (1997) (79)
Increased 8-hydroxyguanine levels in DNA and its repair activity in rat kidney after administration of a renal carcinogen, ferric nitrilotriacetate. (1996) (77)
UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin. (2008) (77)
DNA modifications by the mutagen glyoxal: adduction to G and C, deamination of C and GC and GA cross-linking. (1998) (76)
Effects of forced and spontaneous exercise on 8-hydroxydeoxyguanosine levels in rat organs. (1998) (74)
Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beef. (1980) (74)
8-Hydroxyguanine, a DNA adduct formed by oxygen radicals: its implication on oxygen radical-involved mutagenesis/carcinogenesis. (1991) (74)
Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dG. (2009) (73)
Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells. (1997) (72)
Inter-laboratory Validation of Procedures for Measuring 8-oxo-7,8-dihydroguanine/8-oxo-7,8-dihydro-2′-deoxyguanosine in DNA (2002) (71)
Ubiquitous Presence in Mammalian Cells of Enzymatic Activity Specifically Cleaving 8‐Hydroxyguanine‐containing DNA (1992) (70)
Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study. (2012) (69)
Chemical Synthesis of 2-Amino-3-methylimidazo- [4, 5-f]quinoline (IQ), a Potent Mutagen Isolated from Broiled Fish (1980) (69)
Detection of lipid peroxidation-induced DNA adducts caused by 4-oxo-2(E)-nonenal and 4-oxo-2(E)-hexenal in human autopsy tissues. (2010) (68)
Comparison of Oxidation Products from DNA Components by γ-Irradiation and Fenton-Type Reactions (1997) (68)
8-hydroxyguanine levels in nuclear DNA and its repair activity in rat organs associated with age. (1996) (67)
Leanness, Smoking, and Enhanced Oxidative DNA Damage (2006) (67)
Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA. (2002) (67)
Effects of Fe3O4 Magnetic Nanoparticles on A549 Cells (2013) (66)
Biosynthesis of the modified nucleoside Q in transfer RNA. (1976) (66)
The mutations induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP,in Escherichia coli. (1998) (66)
Effect of age, smoking and other lifestyle factors on urinary 7‐methylguanine and 8‐hydroxydeoxyguanosine (2009) (65)
Body iron store as a predictor of oxidative DNA damage in healthy men and women (2010) (63)
Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway (2010) (63)
The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells. (1998) (61)
Chronic arsenic exposure and urinary 8-Hydroxy-2′-deoxyguanosine in an arsenic-affected area in Inner Mongolia, China (2005) (61)
Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA (1979) (61)
Inhibition of 8-hydroxyguanine repair in testes after administration of cadmium chloride to GSH-depleted rats. (1997) (61)
Body mass index and oxidative DNA damage: A longitudinal study (2007) (61)
Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine. (1995) (60)
Photosensitized formation of 8-hydroxydeoxyguanosine in cellular DNA by riboflavin. (1992) (60)
Methylglyoxal induces G:C to C:G and G:C to T:A transversions in the supF gene on a shuttle vector plasmid replicated in mammalian cells. (2000) (58)
Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjects. (2003) (55)
Oxidative DNA damage induced by silica in vivo. (1995) (55)
Stable isotope dilution quantification of mutagens in cooked foods by combined liquid chromatography-thermospray mass spectrometry. (1986) (54)
Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli: effects of sequence contexts in leading and lagging strands. (1997) (54)
2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity. (2000) (53)
Mutations induced by 2-hydroxyadenine on a shuttle vector during leading and lagging strand syntheses in mammalian cells. (1997) (52)
Structure of 7,12-dimethylbenz(a)anthracene-guanosine adducts. (1976) (51)
Analysis of 8-OH-dG and 8-OH-Gua as Biomarkers of Oxidative Stress (2008) (50)
Effect of methyl substitution on mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, isolated from broiled sardine. (1981) (50)
Mutational specificity of glyoxal, a product of DNA oxidation, in the lacI gene of wild-type Escherichia coli W3110. (1997) (50)
A potent mutagen in broiled fish. Part 1. 2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline (1981) (49)
Possible correlation between DNA damage induced by hydrogen peroxide and translocation of heat shock 70 protein into the nucleus. (1995) (49)
Habitual exercise induced resistance to oxidative stress (2005) (48)
Evidence for the accumulation of oxidative stress during cellular ageing of human diploid fibroblasts. (1994) (47)
Induction of oh8Gua glycosylase in rat kidneys by potassium bromate (KBrO3), a renal oxidative carcinogen. (1996) (46)
Inhibition by wheat sprout (Triticum aestivum) juice of bisphenol A-induced oxidative stress in young women. (2011) (46)
Analysis of 8-hydroxy-2'-deoxyguanosine in urine using high-performance liquid chromatography-electrospray tandem mass spectrometry. (2007) (45)
8-hydroxydeoxyguanosine levels in DNA of human breast cancer are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. (1995) (45)
Prevention of spontaneous hepatocellular carcinoma in long‐evans cinnamon rats with hereditary hepatitis by th administration of d‐penicillamine (1993) (45)
Psychological Mediation of a Type of Oxidative DNA Damage, 8-Hydroxydeoxyguanosine, in Peripheral Blood Leukocytes of Non-Smoking and Non-Drinking Workers (2002) (44)
Hydroxylation of the C-8 position of deoxyguanosine by reducing agents in the presence of oxygen. (1983) (44)
Construction of mutants of Salmonella typhimurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro compounds. (1997) (44)
Classical conditioning of oxidative DNA damage in rats (2000) (43)
Effects of sequence contexts on misincorporation of nucleotides opposite 2‐hydroxyadenine (1996) (43)
The Stability of the Oxidative Stress Marker, Urinary 8‐hydroxy‐2'‐ deoxyguanosine (8‐OHdG), when Stored at Room Temperature (2008) (43)
Acute arsenite-induced 8-hydroxyguanine is associated with inhibition of repair activity in cultured human cells. (2002) (43)
Analysis of mutagens from cooked foods by directly combined liquid chromatography-mass spectrometry. (1986) (43)
Letter: Structures of gonyautoxin II and III from the East Coast toxic dinoflagellate Gonyaulax tamarensis. (1976) (42)
Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals. (1995) (42)
DNA strand cleavage at 8-hydroxyguanine residues by hot piperidine treatment. (1992) (42)
Reduction of 8-hydroxyguanine in human leukocyte DNA by physical exercise. (1998) (42)
What causes human cancer? Approaches from the chemistry of DNA damage (2016) (42)
Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. (2006) (41)
Simultaneous determination of 8-hydroxydeoyguanosine, a marker of oxidative stress, and creatinine, a standardization compound, in urine. (2005) (41)
Neopterin, a marker of immune response, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, correlate at high age as determined by automated simultaneous high-performance liquid chromatography analysis of human urine. (2008) (40)
Mutagenic metabolites in urine and feces of rats fed with 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, a carcinogenic mutagen present in cooked meat. (1987) (40)
Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells. (2007) (40)
Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells. (2009) (38)
Increased 8‐Hydroxyguanine in DNA and Its Repair Activity in Hamster and Rat Lung after Intratracheal Instillation of Crocidolite Asbestos (1999) (38)
Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (2009) (37)
CD and NMR studies on the conformational thermostability of 2-thioribothymidine found in the T psi C loop of thermophile tRNA. (1979) (36)
Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent chromium. (2003) (36)
Deficiency of 8-hydroxyguanine DNA endonuclease activity and accumulation of the 8-hydroxyguanine in mutator mutant (mutM) of Escherichia coli. (1992) (36)
Analysis of 8-hydroxydeoxyguanosine among workers exposed to diesel particulate exhaust: Comparison with urinary metabolites and PAH air monitoring (2005) (35)
Accurate Measurement of 8-OH-dG and 8-OH-Gua in Mouse DNA, Urine and Serum : Effects of X-ray Irradiation (2007) (35)
Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death (2013) (35)
ABSOLUTE CONFIGURATION OF A RIBONUCLEIC ACID ADDUCT FORMED IN VIVO BY METABOLISM OF BENZO(A)PYRENE (1977) (34)
Fractionation of a mutagenic principle from broiled fish by high-pressure liquid chromatography. (1979) (33)
Simultaneous HPLC analysis of 8-hydroxydeoxyguanosine and 7-methylguanine in urine from humans and rodents. (2004) (33)
Urinary 8-hydroxyguanine may be a better marker of oxidative stress than 8-hydroxydeoxyguanosine in relation to the life spans of various species. (2006) (33)
Detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vapor. (2006) (32)
Exposure to polycyclic aromatic hydrocarbons, arsenic and environmental tobacco smoke, nutrient intake, and oxidative stress in Japanese preschool children. (2011) (32)
Identification of 4-oxo-2-hexenal and other direct mutagens formed in model lipid peroxidation reactions as dGuo adducts. (2006) (32)
Chemistry and Distribution of Deleterious Dinoflagellate Toxins (1977) (32)
Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. (2003) (31)
Prospective study of urinary excretion of 7‐methylguanine and the risk of lung cancer: Effect modification by mu class glutathione‐S‐transferases (2007) (31)
Induction of E. coli oh8Gua endonuclease by oxidative stress: its significance in aerobic life. (1996) (31)
DNA methylation at the C-5 position of cytosine by methyl radicals: a possible role for epigenetic change during carcinogenesis by environmental agents. (2009) (31)
Presence of human cellular protein(s) that specifically binds and cleaves 8-hydroxyguanine containing DNA. (1997) (30)
Immunohistochemical Detection of 8-Hydroxy-2'-deoxyguanosine in Paraffin-Embedded Sections of Rat Liver after Carbon Tetrachloride Treatment (1998) (30)
Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation. (1999) (30)
Induction of T --> G and T --> A transversions by 5-formyluracil in mammalian cells. (2002) (30)
4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation, causes DNA adduct formation in mouse organs. (2005) (30)
Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1--a multi-center and multi-biomarker study. (2007) (29)
8-hydroxyguanine in urine and serum as an oxidative stress marker: effects of diabetes and aging. (2013) (29)
Types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium. (1997) (29)
Oxidative DNA damage: mechanisms and significance in health and disease. (2006) (29)
Age-associated change of 8-hydroxyguanine repair activity in cultured human fibroblasts. (1995) (29)
Effect of work conditions and work environments on the formation of 8-OH-dG in nurses and non-nurse female workers. (2008) (28)
Analyses of Oxidative DNA Damage and Its Repair Activity in the Livers of 3′‐Methyl‐4‐dimethylaminoazobenzene‐treated Rodents (2000) (27)
Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme. (2005) (27)
Isolation of hydroxy-Y base from rat liver tRNAPhe. (1979) (27)
Two DNA polymerases of Escherichia coli display distinct misinsertion specificities for 2-hydroxy-dATP during DNA synthesis. (2000) (27)
Chemistry‐Based Studies on Oxidative DNA Damage: Formation, Repair, and Mutagenesis (2010) (27)
Identification of 8-hydroxyguanine glycosylase activity in mammalian tissues using 8-hydroxyguanine specific monoclonal antibody. (1993) (26)
4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation: occurrence, detection and adduct formation. (2008) (26)
Induction of OGG1 Gene Expression by HIV-1 Tat* (2005) (26)
Deficient nucleotide excision repair increases base-pair substitutions but decreases TGGC frameshifts induced by methylglyoxal in Escherichia coli. (1999) (25)
Depressive symptoms and oxidative DNA damage in Japanese municipal employees (2012) (24)
SYNTHESIS OF 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-f]QUINOXALINE (Me-IQx), A POTENT MUTAGEN ISOLATED FROM FRIED BEEF (1981) (24)
Detection of a mouse OGG1 fragment during caspase‐dependent apoptosis: Oxidative DNA damage and apoptosis (2004) (24)
Formation of 8-hydroxyguanine residues in DNA treated with 4-hydroxyaminoquinoline 1-oxide and its related compounds in the presence of seryl-AMP. (1987) (23)
Induction of mutations in mouse FM3A cells by treatment with riboflavin plus visible light and its possible relation with formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA. (1993) (23)
8-hydroxydeoxyguanosine generated in the earthworm Eisenia fetida grown in metal-containing soil. (2008) (23)
Coffee Intake is Associated With Lower Levels of Oxidative DNA Damage and Decreasing Body Iron Storage in Healthy Women (2014) (23)
Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin. (1992) (23)
Determination of carcinogenic potential of mineral fibers by 8-hydroxydeoxyguanosine as a marker of oxidative DNA damage in mammalian cells (1997) (23)
Negative Effect of Long-Term Inhalation of Toner on Formation of 8-Hydroxydeoxyguanosine in DNA in the Lungs of Rats In Vivo (2005) (21)
Increase in 8‐Hydroxyguanine and Its Repair Activity in the Esophagi of Rats Given Long‐term Ethanol and Nutrition‐deficient Diet (2000) (20)
Formation of 8-hydroxyguanine in DNA by aging and oxidative stress (1995) (20)
Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid. (2006) (20)
Cross-sectional study on respiratory effect of toner-exposed work in manufacturing plants, Japan: pulmonary function, blood cells, and biochemical markers (2009) (20)
Perceived Stress, Depressive Symptoms, and Oxidative DNA Damage (2017) (19)
DNA‐biding of IQ, Me‐IQ and Me‐IQx, strong mutagens found in broiled foods (1982) (19)
Measurement of 8-hydroxyguanine as an oxidative stress biomarker in saliva by HPLC-ECD (2018) (19)
Genotoxicity of ribo- and deoxyribonucleosides of 8-hydroxyguanine, 5-hydroxycytosine, and 2-hydroxyadenine: induction of SCE in human lymphocytes and mutagenicity in Salmonella typhimurium TA 100. (1998) (19)
Cross-sectional study on respiratory effect of toner exposure (2009) (19)
Increase in the 8-hydroxyguanine repair activity in the rat kidney after the administration of a renal carcinogen, ferric nitrilotriacetate. (1996) (19)
8-Hydroxyguanine, an Oxidative DNA and RNA Modification (2016) (18)
Formation of 8‐hydroxy‐2′‐deoxyguanosine in the DNA of cultured human keratinocytes by clinically used doses of narrowband and broadband ultraviolet B and psoralen plus ultraviolet A (2006) (18)
Age-associated increase of 8-hydroxydeoxyguanosine in human colorectal tissue DNA. (2001) (18)
Analysis of 8‐hydroxydeoxyguanosine 5′‐monophosphate (8‐OH‐dGMP) as a reliable marker of cellular oxidative DNA damage after γ‐irradiation (2003) (18)
Structure Determination of a Modified Nucleoside Isolated from Escherichia coli Transfer Ribonucleic Acid (1976) (17)
BENZO(A)PYRENE DIOL EPOXIDES AS INTERMEDIATES IN NUCLEIC ACID BINDING IN VITRO AND IN VIVO (1976) (17)
Inhibition of Nucleolar Function and Morphological Change by Adriamycin Associated with Heat Shock Protein 70 Accumulation (1996) (17)
PUFAs in serum cholesterol ester and oxidative DNA damage in Japanese men and women. (2012) (17)
Formation of 8-hydroxydeoxyguanosine in calf thymus DNA treated in vitro with phenylhydroquinone, the major metabolite of O-phenylphenol. (1995) (16)
Mutations induced by glyoxal and methylglyoxal in mammalian cells. (2000) (16)
Deoxyribonucleic acid (DNA) damage induced by bleomycin-Fe(II) in vitro: formation of 8-hydroxyguanine residues in DNA. (1989) (16)
Analysis of 8-hydroxyguanine in rat kidney genomic DNA after administration of a renal carcinogen, ferric nitrilotriacetate. (1999) (16)
Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase. (2004) (16)
Serum vitamin B6, folate, and homocysteine concentrations and oxidative DNA damage in Japanese men and women. (2013) (16)
The Crystal Structure of 9-Ethyl-8-hydroxyguanine (1987) (15)
The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein. (2002) (15)
STRUCTURES OF GONYAUTOXIN II AND III FROM THE EAST COAST TOXIC DINOFLAGELLATE GONYAULAX TAMARENSIS (1976) (15)
Syntheses of 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline and Its Related Compounds (1982) (15)
Nucleotide excision repair proteins may be involved in the fixation of glyoxal-induced mutagenesis in Escherichia coli. (1998) (15)
Increased Levels of 8‐Hydroxy‐2′‐Deoxyguanosine in Drosophila Larval DNA after Irradiation with 364‐nm Laser Light but not with X‐rays (2007) (15)
8‐Chloro‐dGTP, a hypochlorous acid‐modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog (2002) (14)
Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication. (2001) (14)
Fragmentation of the DNA Repair Enzyme, OGG1, in Mouse Nonparenchymal Liver Cells by Arsenic Compounds (2006) (14)
UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides. (2007) (14)
Formation, inhibition of formation, and repair of oxidative 8-hydroxyguanine DNA damage. (1993) (14)
Comparison of oxidation products from DNA components by gamma-irradiation and Fenton-type reactions. (1997) (14)
Under-modified Y base in a tRHAPhe isoacceptor observed in tumor cells. (1979) (14)
Novel mechanism of post-transcriptional modification of tRNA: insertion of base of Q precursor into tRNA by tRNA transglycosidase reaction (1978) (14)
Negative association between serum dioxin level and oxidative DNA damage markers in municipal waste incinerator workers (2006) (14)
The biochemical studies on phalloidin-induced cholestasis in rats. (1997) (13)
DNA modifications by the omega-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal in vitro and their analysis in mouse and human DNA. (2010) (13)
Analysis of 8-hydroxyguanine (8-OH-Gua) released from DNA by the formamidopyrimidine DNA glycosylase (Fpg) protein: a reliable method to estimate cellular oxidative stress. (2004) (13)
Effect of polymerized toner on rat lung in chronic inhalation study (2009) (13)
Detection of a smaller, 32‐kDa 8‐oxoguanine DNA glycosylase 1 in 3′‐methyl‐4‐dimethylamino‐azobenzene‐treated mouse liver (2004) (12)
Comparison of Blueberry (Vaccinium spp.) and Vitamin C via Antioxidative and Epigenetic Effects in Human (2017) (12)
Effects of instant coffee consumption on oxidative DNA damage, DNA repair, and redox system in mouse liver. (2009) (12)
2-Hydroxyadenine (isoguanine) as oxidative DNA damage: its formation and mutation inducibility. (1995) (12)
Urinary 1‐hydroxypyrene and 8‐hydroxydeoxyguanosine Levels among Coke‐oven Workers for 2 Consecutive Days (2014) (12)
Identification of novel 7,12-dimethylbenz[a]anthracene adducts in cellular ribonucleic acid. (1981) (12)
8-Hydroxyguanine levels and repair capacity during mouse embryonic stem cell differentiation (2011) (12)
Formation of 8-Hydroxyguanine by Oxidative DNA Damage, Its Repair and Its Mutagenic Effects (1993) (12)
Lower serum levels of total cholesterol are associated with higher urinary levels of 8-hydroxydeoxyguanosine (2013) (12)
Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese (2016) (12)
Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage (2009) (11)
Sequence specificity of the 8-hydroxyguanine repair activity in rat organs. (2001) (11)
Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. (2001) (11)
2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract. (2007) (11)
Hypersensitivity of a Urate-null Strain of Drosophila melanogaster to the Toxic Effects of Environmental Cigarette Smoke (2009) (11)
2-hydroxyadenine in DNA is a very poor substrate of the Escherichia coli MutY protein. (2000) (11)
Immunochemical detection of glyoxal DNA damage. (1999) (10)
Crystal and molecular structures of 2‐amino‐3‐methylimidazo‐[4,5‐f]‐ quinoline, a novel potent mutagen found in broiled food (1980) (10)
Effect of rearing using an electrolyzed seawater on reduction of Vibrio parahaemolyticus from sea urchin [Strongylocentrotus nudus] (2006) (10)
[Anti-atheromatous effects of fenofibrate, a hypolipidemic drug. I: Anti-atheromatous effects are independent of its hypolipidemic effect in cholesterol-fed rabbits]. (1995) (10)
Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. (1997) (9)
[DNA damage by oxygen radicals and carcinogenesis]. (1989) (9)
Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription. (2007) (9)
Generation and Threshold Level of 8-OHdG as Oxidative DNA Damage Elicited by Low Dose Ionizing Radiation (2013) (9)
2-Hydroxyadenine, a mutagenic form of oxidative DNA damage, is not repaired by a glycosylase type mechanism in rat organs. (1998) (8)
Somatic cell mutations caused by 365 nm LED-UVA due to DNA double-strand breaks through oxidative damage. (2014) (8)
Structures of 7,12-dimethylbenz[a]anthracene 5,6-oxide derivatives linked to the ribose moiety of guanosine (1977) (8)
Characterization and analysis of oncofetal tRNA and its possible application for cancer diagnosis and therapy. (1983) (8)
STRUCTURE OF A POTENT MUTAGEN ISOLATED FROM FRIED BEEF (1981) (8)
Formation of 8-hydroxydeoxyguanosine in DNA by auto-oxidized unsaturated fatty acids (1988) (7)
An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates. (2002) (7)
Cloning and characterization of an ascidian homolog of the human 8-oxoguanine DNA glycosylase (Ogg1) that is involved in the repair of 8-oxo-7,8-dihydroguanine in DNA in Ciona intestinalis (2006) (7)
Magnetic nanoparticles of Fe 3 O 4 enhance docetaxel-induced prostate cancer cell death (2013) (7)
Diurnal and day-to-day variation of urinary oxidative stress marker 8-hydroxy-2'-deoxyguanosine (2020) (7)
DNA Methylation at the C-5 Position of Cytosine by a Methyl Radical: A Link between Environmental Agents and Epigenetic Change (2011) (7)
Lack of initiation activity of 4-oxo-2-hexenal, a peroxidation product generated from omega-3 polyunsaturated fatty acids, in an in vivo five-week liver assay. (2007) (7)
Analysis of Cytosolic Phosphoethanolamine and Ethanolamine and Their Correlation with Prognostic Factors in Breast Cancer (1991) (7)
Two micromethods for determining the linkage of adducts formed between polyaromatic hydrocarbons and nucleic acid bases (1978) (7)
Relations between clusters of oxidatively damaged nucleotides and active or open nucleosomes in the rat Nth 1 gene (2002) (6)
Evaluation of Oxidative Damage Induced by Natural Sunlight in Drosophila (2006) (6)
Urinary 8-hydroxydeoxyguanosine levels and psychological reactions after sleep deprivation. (2010) (6)
Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats. (1997) (6)
Crystal and molecular structure of the acetonide of 5‐methylaminomethyl‐2‐thiouridine A minor constituent of Escherichia coli tRNAs (1979) (6)
PREPARATION OF 8-HYDROXY-DGTP AND 2-HYDROXY-DATP BY A PHOSPHATE TRANSFER REACTION BY NUCLEOSIDE-DIPHOSPHATE KINASE (1999) (6)
Methylreductic acid and hydroxymethylreductic acid: oxygen radical-forming agents in heated starch. (1989) (6)
Dietary non-enzymatic antioxidant capacity and DNA damage in a working population. (2018) (6)
Stereochemistry of the cyclopentene side chain in the nucleoside Q obtained from tRNA (1976) (6)
Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis (2013) (5)
Increase of Urinary 8-OH-dG Levels after Administration of a Vitamin-deficient Diet and a Sweet Beverage (2007) (5)
Distributions and ranges of values of blood and urinary biomarker of inflammation and oxidative stress in the workers engaged in office machine manufactures: evaluation of reference values (2012) (5)
A very low level of magnetic field exposure does not affect a participant's mental fatigue and stress as much as VDT work. (2005) (5)
Formation of 8-Hydroxydeoxyguanosine in DNA and Carcinogenesis (1991) (5)
Induction of 8-oxoguanine DNA Glycosylase 1 Gene Expression by HIV-1 Tat (2005) (4)
Misreading of 8-hydroxydeoxyguanosine-containing DNA in in vitro DNA replication. (1986) (4)
Identification of octenal-related dA and dC adducts formed by reactions with a hemin-ω-6-fat peroxidation model system. (2013) (4)
Structure of a 7,12-dimethylbenz[a]anthracene 5,6-oxide derivative bound to C-8 of guanosine (1980) (4)
Leisure-time physical activity and DNA damage among Japanese workers (2019) (4)
Detection of Genotoxic Nucleosides, 8-Hydroxydeoxyguanosine, 8-Hydroxyguanosine and Free Base 8-Hydroxyguanine, in Fish Food Products (2006) (3)
Analysis of 8-Hydroxy-2′-Deoxyguanosine as a Marker of Oxidatively Damaged DNA in Relation to Carcinogenesis and Aging (2007) (3)
[Anti-atheromatous effects of fenofibrate, a hypolipidemic drug. II: Anti-atheromatous effects are independent of its hypolipidemic effect in hereditary hyperlipidemic rabbits]. (1995) (3)
Methionine Sulfoxide Stimulates Hepatocarcinogenesis in Non-alcoholic Steatohepatitis (NASH) Mouse: Possible Role of Free Radical-mediated DNA Methylation (2012) (3)
Formation of 8-Hydroxyguanine in DNA by Oxygen Radicals and Its Repair Enzyme (1993) (2)
Mutagenicity of 5-formyluracil in mammalian cells. (2000) (2)
The choleretic effects of N-acetylglucosaminides, major urinary metabolites of ursodeoxycholic acid, in bile fistula rats. (1998) (2)
Chronic alcohol consumption prevents 8-hydroxyguanine accumulation in 3'-methyl-4-dimethylaminoazobenzene-treated mouse liver. (2009) (2)
Analyses of 8-Methyldeoxyadenosine and 8-Methyldeoxyguanosine as Markers of Free Radical-mediated DNA Methylation in Mouse (2013) (2)
[Relationship between length of sleep and oxidative stress marker, urinary 8-hydroxy-2'-deoxyguanosine]. (2006) (2)
Overexpression of the hOGG 1 Gene and High 8-Hydroxy-2 *-deoxyguanosine ( 8-OHdG ) Lyase Activity in Human Colorectal Carcinoma : Regulation Mechanism of the 8-OHdG Level in DNA 1 (2000) (2)
The effect of smoking on 8-hydroxydeoxyguanosine levels in human lung DNA (1990) (2)
CIGARETTE SMOKING INDUCES FORMATION OF OXIDATIVE DNA DAMAGES IN HUMAN PERIPHERAL LEUKOCYTES %HYDROXYDEOXYGUANOSINE, ONE OF THE (1990) (1)
Formation of mutagenic IQ dimer by peroxidase treatment of IQ (1986) (1)
P-107 DNA methylation at the C-5 position of cytosine by methyl radicals : a possible role for epigenetic change during carcinogenesis by environmental agents(Epigenetics,Poster Session) (2009) (1)
Hydroxyguanine in carcinogenesis (1998) (1)
Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract (2006) (1)
Environmental mutagen society of Japan Selected abstract of the 15th Annual Meeting of the Environmental Mutagen Society of Japan 1–3 October 1986, Tokyo (Japan)DNA-damaging agents in heated starch (1987) (1)
Free radical-mediated acetaldehyde formation by model reactions of dietary components: effects of meat, wine, cooking oil and coffee (2021) (1)
Increased 8-Hydroxyguanine Repair Activity in Animal Livers and Human Leukocytes Induced by Oxidative Stress: Effects of Diet, Physical Exercise, and Cigarette Smoking (1997) (1)
435 Reliability of the level of urinary 8-hydroxy — 2′ deoxyguanosine (8-OHDG) and its usefulness for epidemiological studies (2003) (1)
Formation of 8-OH-dG by oxidative stress and response of repair enzymes(the symposium 2 "Mechanism of DNA damege and mutation" at the 32nd JEMS annual meeting, 2003.) (2004) (1)
Detection and identification of mutagens by the adducts formed upon reaction with guanosine derivatives. (1986) (1)
New Plausible Mechanism for Gastric and Colorectal Carcinogenesis: Free Radical-Mediated Acetaldehyde Generation in a Heme/Myoglobin–Linoleate–Ethanol Mixture (2021) (1)
Molecular structure of Q nucleotide. (1979) (1)
P-030(O-5) Structures of Octenal-related dA- and dC-adducts Formed in Hemin-ω-6-lipid Peroxidation Model Reactions(Poster presentation) (2013) (0)
Pyrimidine Ring-Opened Product from Oxidative DNA Damage of 5-Formyl-2'-deoxyuridine. (2019) (0)
Formation of 2-hydroxydeoxyadenosine from deoxyadenosine by oxygen radicals and induction of sister chromatid exchange (SCE) by its derivatives (1996) (0)
Effects of Various Nanoparticles on Human Cells: Cell Specificity and its Application (2011) (0)
ANALYSIS OF OXIDATIVE DNA DAMAGE IN THE RAT AFTER ADMINISTRATION OF A RENAL CARCINOGEN (2001) (0)
Reactive Oxygen Species (ROS) and Exercise : 2SB5:Physical Exercise and Oxidative DNA Damage (2002) (0)
O-15 A multi-center and multi-biomarker study of oxidative stress in adolescents exposed to AFB1(ACEM Oral Presentation III) (2007) (0)
Incorporation by DNA polymerases of 2-hydroxy-deoxyadenosine triphosphate, an oxidatively damaged nucleotide (1996) (0)
Analysis of 8-Hydroxyguanine in DNA and Its Repair (2002) (0)
P058 A multi-center and multi-biomarker study of oxidative stress in adolescents exposed to AFB1 (2007) (0)
What causes human cancer? Approaches from the chemistry of DNA damage (2016) (0)
STRUCTURES OF 7,12-DIMETHYLBENZ(A)ANTHRACENE 5,6-OXIDE DERIVATIVES LINKED TO THE RIBOSE MOIETY OF GUANOSINE (1978) (0)
Isolation of a potent mutagen from cooked beef (1980) (0)
The choleretic effect of N-acetylglucosamine conjugates of Ursodeoxycholic acid (UDCA) in bile fistura rats (1997) (0)
Mutagenic properties of oxidized GTP and ATP in in vitro transcription-reverse transcription. (2006) (0)
SYNTHESES OF 2-AMINO-3,4-DIMETHYL-3H-IMIDAZO(4,5-F)QUINOLINE AND ITS RELATED COMPOUNDS (1982) (0)
The sensitivity of mutMST disrupted strains of Salmonella typhimurium against mutagens that cause oxidative DNA damage (1996) (0)
A POTENT MUTAGEN IN BROILED FISH. PART 1. 2-AMINO-3-METHYL-3H-IMIDAZO(4,5-F)QUINOLINE (1981) (0)
1218 Salivary oxidative stress biomarker: 8-hydroxyguanosine (2018) (0)
Specific alteration of post-transcriptional modification of tRNA in tumor cells. (1982) (0)
O XVII A.2 Mutagenesis and carcinogenesis induced by oxygen radicals: Roles of 8-hydroxyguanine, 2-hydroxyadenine, and glyoxal formation (1997) (0)
Detection of mutagens as their adducts after reaction with guanosine derivatives (1985) (0)
Determination of oxidative DNA damage, 8-hydroxyguanine, in gamma-irradiated human A549 cells (2002) (0)
Formation of glyoxal by exposure of DNA to oxygen free-radicals (1996) (0)
Biological Indicators of Lifestyle-related Diseases and Urinary 8-Hydroxydeoxyguanosine Level (2009) (0)
Formation of 5-Formy-dC from 5-Methyl-dC by γ-Irradiarion and FentonType Reactions (1999) (0)
Free radical-mediated acetaldehyde formation by model reactions of dietary components: effects of meat, wine, cooking oil and coffee (2021) (0)
[DNA lesions produced by active oxygen and their induced mutations]. (1995) (0)
SYNTHESIS OF 2-AMINO-3,8-DIMETHYLIMIDAZO(4,5-F)QUINOXALINE (ME-IQX), A POTENT MUTAGEN ISOLATED FROM FRIED BEEF (1981) (0)
Measurement of 8-hydroxyguanine as an oxidative stress biomarker in saliva by HPLC-ECD (2018) (0)
S-08 4-Oxo-2-hexenal, a mutagen formed by ω-3 fat peroxidation : occurrence, detection and adduct formation(ACEM Symposium II:Mutagens and anti-mutagens in Asian foods) (2007) (0)
8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic and Carcinogenic Action of Oxygen Radical-Forming Agents (1991) (0)
P-142 Simultaneous analysis of various oxidative DNA adducts in human tissues using LC-MS/MS(Poster Session) (2008) (0)
1,4-Dihydroxy-2-naphthoic Acid Sulfate: A Promising Constipation Preventive Agent (2021) (0)
P017 Detection of 8-OH-dG, ribonucleoside 8-OH-Guo and free base 8-OH-Gua in fish food products(Poster Session) (2006) (0)

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