Hiroshi Kawaguchi
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Computer Science
Hiroshi Kawaguchi's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Hiroshi Kawaguchi's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mutation of the mouse klotho gene leads to a syndrome resembling ageing (1997) (3243)
- OARSI guidelines for the non-surgical management of knee osteoarthritis. (2014) (2545)
- Suppression of Aging in Mice by the Hormone Klotho (2005) (1618)
- PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. (2004) (834)
- Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study (2009) (636)
- Osteoarthritis development in novel experimental mouse models induced by knee joint instability. (2005) (495)
- Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis (2004) (462)
- Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development (2010) (454)
- The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. (2004) (356)
- Long-Term Results of Double-Door Laminoplasty for Cervical Stenotic Myelopathy (2001) (354)
- Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. (2009) (336)
- Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. (1994) (330)
- Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. (2006) (308)
- The role of prostaglandins in the regulation of bone metabolism. (1995) (305)
- Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1* (2004) (297)
- Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways (2006) (295)
- Suppressive function of androgen receptor in bone resorption (2003) (287)
- Nosocomial infections in adult intensive-care units (2003) (281)
- Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. (2012) (270)
- Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. (2000) (264)
- Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3‐only Bcl‐2 family member Bim (2003) (258)
- Connection Between B Lymphocyte and Osteoclast Differentiation Pathways1 (2001) (226)
- Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling (2007) (225)
- Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. (2014) (221)
- Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency (2007) (207)
- In situ single cell observation by fluorescence resonance energy transfer reveals fast intra‐cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine (2004) (200)
- Cohort profile: research on Osteoarthritis/Osteoporosis Against Disability study. (2010) (200)
- Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials. (2006) (197)
- Klotho Gene Polymorphisms Associated With Bone Density of Aged Postmenopausal Women (2002) (191)
- Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency. (2003) (191)
- Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. (1999) (186)
- Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. (1993) (177)
- Strong Static Magnetic Field Stimulates Bone Formation to a Definite Orientation In Vitro and In Vivo (2002) (177)
- Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL) (1999) (168)
- Acceleration of fracture healing in nonhuman primates by fibroblast growth factor-2. (2001) (167)
- Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study. (2012) (161)
- Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. (2002) (160)
- A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo‐controlled trial (2010) (160)
- Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 (2010) (156)
- The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. (2005) (152)
- Regulation of Osteoblast, Chondrocyte, and Osteoclast Functions by Fibroblast Growth Factor (FGF)-18 in Comparison with FGF-2 and FGF-10* (2002) (152)
- Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation. (1997) (151)
- Dnm3os, a non‐coding RNA, is required for normal growth and skeletal development in mice (2008) (151)
- Involvement of Endogenous Bone Morphogenetic Protein (BMP) 2 and BMP6 in Bone Formation* (2005) (150)
- Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo. (2004) (144)
- Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development (2013) (142)
- Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. (1995) (142)
- Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models. (2008) (139)
- Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts (2002) (139)
- Association of Knee Osteoarthritis with the Accumulation of Metabolic Risk Factors Such as Overweight, Hypertension, Dyslipidemia, and Impaired Glucose Tolerance in Japanese Men and Women: The ROAD Study (2011) (138)
- Association between new indices in the locomotive syndrome risk test and decline in mobility: third survey of the ROAD study (2015) (137)
- GSK-3β Controls Osteogenesis through Regulating Runx2 Activity (2007) (136)
- Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. (2008) (133)
- Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine) on poly(ether-ether-ketone). (2010) (132)
- Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. (2013) (132)
- Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation (2005) (131)
- Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. (2004) (125)
- Is osteoporosis a predictor for future sarcopenia or vice versa? Four-year observations between the second and third ROAD study surveys (2016) (125)
- Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae. (1995) (123)
- Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells. (1994) (122)
- C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. (2012) (122)
- Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae. (1994) (122)
- Bone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6 (2004) (122)
- Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. (2007) (117)
- Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts: the ROAD study (2008) (113)
- Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing. (2004) (113)
- Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD study. (2010) (111)
- Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice (2005) (111)
- Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. (2002) (109)
- S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes (2007) (108)
- A new technique to expand human mesenchymal stem cells using basement membrane extracellular matrix. (2004) (106)
- Fully automatic quantification of knee osteoarthritis severity on plain radiographs. (2008) (105)
- Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: a longitudinal population-based cohort study. (2012) (103)
- Immunohistochemical Demonstration of Bone Morphogenetic Protein‐2 and Transforming Growth Factor‐β in the Ossification of the Posterior Longitudinal Ligament of the Cervical Spine (1992) (101)
- Insulin Secretory Response Is Positively Associated with the Extent of Ossification of the Posterior Longitudinal Ligament of the Spine (2001) (97)
- Diet and lifestyle associated with increased bone mineral density: cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic (2007) (97)
- Fibroblast Growth Factor (FGF)-2 Directly Stimulates Mature Osteoclast Function through Activation of FGF Receptor 1 and p42/p44 MAP Kinase* (2000) (97)
- Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study (2014) (96)
- Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. (2010) (96)
- Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: comparisons with the effect of polyethylene cross-linking and ceramic femoral heads. (2009) (94)
- Mortality and morbidity after high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury: a propensity-matched analysis using a nationwide administrative database (2013) (92)
- The association of combination of disc degeneration, end plate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study. (2015) (91)
- Prevalence of falls and the association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women (2011) (90)
- Optimal Combination of Soluble Factors for Tissue Engineering of Permanent Cartilage from Cultured Human Chondrocytes* (2007) (89)
- Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials. (2012) (88)
- Distinct osteogenic mechanisms of bones of distinct origins (2004) (87)
- Mortality and morbidity in dialysis-dependent patients undergoing spinal surgery: analysis of a national administrative database in Japan. (2012) (87)
- Runx1 and Runx2 cooperate during sternal morphogenesis (2010) (85)
- Distinct effects of PPARγ insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells (2005) (85)
- Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice. (2005) (85)
- Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts: a large-scale population-based study. (2009) (84)
- Regulation of Osteoclast Differentiation by Fibroblast Growth Factor 2: Stimulation of Receptor Activator of Nuclear Factor κB Ligand/Osteoclast Differentiation Factor Expression in Osteoblasts and Inhibition of Macrophage Colony‐Stimulating Factor Function in Osteoclast Precursors (2001) (84)
- Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. (2007) (84)
- Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study (2011) (84)
- Sagittal spino-pelvic alignment in adults: The Wakayama Spine Study (2017) (83)
- Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma (2009) (82)
- Radiographic Analysis of the Cervical Spine in Patients With Retro-Odontoid Pseudotumors (2009) (81)
- Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions. (2002) (81)
- Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study (2015) (80)
- C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2 (2009) (80)
- Mechanism of Stimulation of Osteoclastic Bone Resorption through Gas6/Tyro 3, a Receptor Tyrosine Kinase Signaling, in Mouse Osteoclasts* (2001) (80)
- Direct and Indirect Actions of Fibroblast Growth Factor 2 on Osteoclastic Bone Resorption in Cultures (2000) (79)
- SP7 Inhibits Osteoblast Differentiation at a Late Stage in Mice (2012) (78)
- Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study. (2017) (78)
- Stimulation of bone formation by intraosseous application of recombinant basic fibroblast growth factor in normal and ovariectomized rabbits (1997) (77)
- Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. (2008) (75)
- Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer (2006) (75)
- A novel disease-modifying osteoarthritis drug candidate targeting Runx1 (2012) (74)
- Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis. (2007) (74)
- Natural Course and Prognostic Factors in Patients With Mild Cervical Spondylotic Myelopathy With Increased Signal Intensity on T2-Weighted Magnetic Resonance Imaging (2012) (74)
- Postoperative Expansion of Intramedullary High-Intensity Areas on T2-Weighted Magnetic Resonance Imaging After Cervical Laminoplasty (2004) (73)
- Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: the ROAD study (2015) (73)
- Gli1 Protein Participates in Hedgehog-mediated Specification of Osteoblast Lineage during Endochondral Ossification* (2012) (73)
- Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2 (2015) (72)
- Erk pathways negatively regulate matrix mineralization. (2007) (71)
- Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage. (2010) (71)
- Osteoclast Differentiation by RANKL Requires NF‐κB‐Mediated Downregulation of Cyclin‐Dependent Kinase 6 (Cdk6) (2004) (70)
- Nucleotide Pyrophosphatase Gene Polymorphism Associated With Ossification of the Posterior Longitudinal Ligament of the Spine (2002) (68)
- Incidence of certified need of care in the long‐term care insurance system and its risk factors in the elderly of Japanese population‐based cohorts: The ROAD study (2014) (67)
- Impairment of Bone Healing by Insulin Receptor Substrate-1 Deficiency* (2004) (67)
- Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes (2016) (66)
- A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine (2006) (65)
- Enhanced wear resistance of modified cross-linked polyethylene by grafting with poly(2-methacryloyloxyethyl phosphorylcholine). (2007) (64)
- Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study (2009) (63)
- Regulation of Osteoarthritis Development by Wnt–β‐catenin Signaling Through the Endochondral Ossification Process (2009) (62)
- Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study (2014) (62)
- Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study (2013) (62)
- Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene. (2009) (62)
- Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells. (2009) (60)
- Can Laminoplasty Maintain the Cervical Alignment Even When the C2 Lamina Is Contained? (2005) (60)
- Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study (2019) (60)
- The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions. (2010) (60)
- Acute Cervical Spinal Cord Injury Complicated by Preexisting Ossification of the Posterior Longitudinal Ligament: A Multicenter Study (2011) (59)
- High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethyl phosphorylcholine). (2007) (59)
- Association Analysis of Single Nucleotide Polymorphisms in Cartilage‐Specific Collagen Genes With Knee and Hip Osteoarthritis in the Japanese Population (2002) (58)
- Bone Morphogenetic Protein 2 Induces Cyclo‐oxygenase 2 in Osteoblasts via a Cbfa1 Binding Site: Role in Effects of Bone Morphogenetic Protein 2 In Vitro and In Vivo (2002) (58)
- Identification of Fibroblast Growth Factor-18 as a Molecule to Protect Adult Articular Cartilage by Gene Expression Profiling* (2014) (57)
- Chondromodulin I Is a Bone Remodeling Factor (2003) (57)
- Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: 10-year follow-up of the Taiji cohort (2011) (56)
- Carminerin contributes to chondrocyte calcification during endochondral ossification (2006) (56)
- Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells. (2004) (56)
- Hedgehog-Gli Activators Direct Osteo-chondrogenic Function of Bone Morphogenetic Protein toward Osteogenesis in the Perichondrium* (2013) (55)
- MRI-defined paraspinal muscle morphology in Japanese population: The Wakayama Spine Study (2017) (54)
- Effects of mobility/immobility of surface modification by 2-methacryloyloxyethyl phosphorylcholine polymer on the durability of polyethylene for artificial joints. (2009) (54)
- Bone Morphogenetic Protein 2 Induces Cyclo‐oxygenase 2 in Osteoblasts via a Cbfa1 Binding Site: Role in Effects of Bone Morphogenetic Protein 2 In Vitro and In Vivo (2005) (54)
- Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis Development* (2013) (53)
- HIF-2α as a possible therapeutic target of osteoarthritis. (2010) (53)
- Long‐term hip simulator testing of the artificial hip joint bearing surface grafted with biocompatible phospholipid polymer (2014) (52)
- Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. (2005) (52)
- The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease. (2008) (52)
- Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis (2011) (52)
- Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells (2005) (52)
- Synergistic Effects of FGF-2 with Insulin or IGF-I on the Proliferation of Human Auricular Chondrocytes (2005) (52)
- Krüppel-like Factor 5 Causes Cartilage Degradation through Transactivation of Matrix Metalloproteinase 9* (2008) (51)
- Effects of photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on physical properties of cross-linked polyethylene in artificial hip joints (2007) (50)
- Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator. (2008) (50)
- Superlubricious surface mimicking articular cartilage by grafting poly(2-methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings. (2009) (49)
- Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: the ROAD Study. (2013) (49)
- Cartilage-mimicking, High-density Brush Structure Improves Wear Resistance of Crosslinked Polyethylene: A Pilot Study (2011) (48)
- Long-Term Results of Operative Treatment for Cervical Spondylotic Myelopathy in Patients With Athetoid Cerebral Palsy: An Over 10-Year Follow-Up Study (2002) (48)
- Impact of knee and low back pain on health-related quality of life in Japanese women: the Research on Osteoarthritis Against Disability (ROAD) (2010) (47)
- 2006 FRANK STINCHFIELD AWARD: Grafting of Biocompatible Polymer for Longevity of Artificial Hip Joints (2006) (46)
- Effect of 2-methacryloyloxyethyl phosphorylcholine concentration on photo-induced graft polymerization of polyethylene in reducing the wear of orthopaedic bearing surface. (2008) (46)
- Identification and characterization of the human long form of Sox5 (L-SOX5) gene. (2002) (45)
- Prevalence of Cervical Cord Compression and Its Association With Physical Performance in a Population-Based Cohort in Japan: The Wakayama Spine Study (2012) (45)
- Prevalence of radiographic hip osteoarthritis and its association with hip pain in Japanese men and women: the ROAD study. (2016) (44)
- Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. (2002) (44)
- Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions. (2010) (43)
- Surface grafting of biocompatible phospholipid polymer MPC provides wear resistance of tibial polyethylene insert in artificial knee joints. (2010) (43)
- SOX11 contributes to the regulation of GDF5 in joint maintenance (2013) (42)
- Health-Related Quality of Life in Subjects With Low Back Pain and Knee Pain in a Population-Based Cohort Study of Japanese Men: The Research on Osteoarthritis Against Disability Study (2011) (42)
- Bone marrow suppression induced by high dose valproic acid. (1994) (42)
- Reduction of Peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair. (2011) (42)
- GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation* (2012) (42)
- A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. (2007) (41)
- Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic features (2009) (41)
- Prevalence of hand osteoarthritis and its relationship to hand pain and grip strength in Japan: The third survey of the ROAD study (2016) (41)
- The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based magnetic resonance imaging study: the Wakayama Spine Study. (2014) (41)
- Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice. (2012) (41)
- Curative effect of combined treatment with alendronate and 1 alpha-hydroxyvitamin D3 on bone loss by ovariectomy in aged rats. (2002) (41)
- Identification of sequence polymorphisms in two sulfation-related genes, PAPSS2 and SLC26A2, and an association analysis with knee osteoarthritis (2001) (40)
- Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. (2004) (40)
- Predictors of residual symptoms in lower extremities after decompression surgery on lumbar spinal stenosis (2010) (40)
- Neurologic Level Diagnosis of Cervical Stenotic Myelopathy (2006) (40)
- Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women: a longitudinal cohort study (2013) (40)
- Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse (2000) (39)
- Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders. (2008) (39)
- A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women (2001) (39)
- Incidence and risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women: the ROAD study. (2012) (39)
- Association of Bone Metabolism Regulatory Factor Gene Polymorphisms With Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine and Its Severity (2002) (38)
- Contribution of membrane‐associated prostaglandin E2 synthase to bone resorption (2003) (37)
- Pivotal Role of Bcl-2 Family Proteins in the Regulation of Chondrocyte Apoptosis* (2008) (36)
- Factors affecting the occurrence of pulmonary embolism after spinal surgery: data from the national administrative database in Japan. (2012) (36)
- Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell‐based sensor (2007) (35)
- Deficiency of Insulin Receptor Substrate‐1 Impairs Skeletal Growth Through Early Closure of Epiphyseal Cartilage (2003) (35)
- Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study (2016) (34)
- Joint space narrowing, body mass index, and knee pain: the ROAD study (OAC1839R1). (2015) (33)
- Enhanced wear resistance of orthopaedic bearing due to the cross-linking of poly(MPC) graft chains induced by gamma-ray irradiation. (2008) (33)
- Clinical and radiographic outcomes of total hip replacement with poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners: Three-year results of a prospective consecutive series (2015) (32)
- Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship—is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study (2009) (31)
- Exposure of macrophage-like cells to titanium particles does not affect bone resorption, but inhibits bone formation (1999) (30)
- Response to Letter to the Editor entitled "Comments on 'OARSI guidelines for the non-surgical management of knee osteoarthritis'". (2014) (30)
- Risk factors for knee osteoarthritis in Japanese men: a case-control study (2006) (30)
- Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor. (2009) (29)
- Continuous Activation of Gαq in Osteoblasts Results in Osteopenia through Impaired Osteoblast Differentiation* (2007) (29)
- Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in osteoarthrosis of the knee and hip joints (2001) (29)
- Revision cervical spine surgery using transarticular or pedicle screws under a computer-assisted image-guidance system (2005) (29)
- Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes. (2005) (28)
- Radiographic Knee Osteoarthritis and Knee Pain: Cross-sectional study from Five Different Racial/Ethnic Populations (2018) (28)
- Association between height loss and bone loss, cumulative incidence of vertebral fractures and future quality of life: the Miyama study (2007) (28)
- Transforming Growth Factor-β1 Regulation of Prostaglandin G/H Synthase-2 Expression in Osteoblastic MC3T3-E1 Cells. (1997) (28)
- SOX10 Transactivates S100B to Suppress Schwann Cell Proliferation and to Promote Myelination (2014) (28)
- Osteoclastic bone resorption through receptor tyrosine kinase and extracellular signal-regulated kinase signaling in mature osteoclasts (2004) (28)
- Association between types of Modic changes in the lumbar region and low back pain in a large cohort: the Wakayama spine study (2020) (28)
- Anabolic effects of 3,3',5-triiodothyronine and triiodothyroacetic acid in cultured neonatal mouse parietal bones. (1994) (27)
- Molecular backgrounds of age-related osteoporosis from mouse genetics approaches (2007) (27)
- Do sarcopenia and/or osteoporosis increase the risk of frailty? A 4-year observation of the second and third ROAD study surveys (2018) (27)
- Wear resistance of the biocompatible phospholipid polymer‐grafted highly cross‐linked polyethylene liner against larger femoral head (2015) (25)
- Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan: a cross-sectional study. (2011) (25)
- Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells (2010) (24)
- Classification of High Intensity Zones of the Lumbar Spine and Their Association with Other Spinal MRI Phenotypes: The Wakayama Spine Study (2016) (24)
- Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation (2014) (24)
- Normal and threshold values of radiographic parameters for knee osteoarthritis using a computer-assisted measuring system (KOACAD): the ROAD study (2010) (24)
- SRC‐1 Is Necessary for Skeletal Responses to Sex Hormones in Both Males and Females (2004) (24)
- The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study (2017) (24)
- Poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liner in primary total hip replacement: one-year results of a prospective cohort study (2013) (24)
- Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. (2013) (24)
- Gαq Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone* (2011) (23)
- Cumulative incidence and changes in the prevalence of vertebral fractures in a rural Japanese community: a 10-year follow-up of the Miyama cohort (2006) (23)
- Correlation between pyramidal signs and the severity of cervical myelopathy (2010) (23)
- Resolution of spinal epidural haematoma without surgery in a haemophilic infant (2004) (22)
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- Stimulation de la formation endostale par l'injection locale intra-osseuse de FGF 2 chez le rat (1997) (0)
- 068Hypoxia-inducible factor 2α (HIF-2α) controls sequential steps of endochondral ossification during skeletal growth and osteoarthritis progression (2009) (0)
- 68 EFFECTS OF VIDEO-BASED HOME EXERCISE ON CLINICAL AND RADIOGRAPHIC OUTCOMES IN ADULTS WITH KNEE OSTEOARTHRITIS: A ONE-YEAR RANDOMIZED CONTROLLED TRIAL (2011) (0)
- 71 NOTCH/RBPJ/HES1 SIGNAL IN CHONDROCYTES MODULATES TERMINAL STAGE OF ENDOCHONDRAL OSSIFICATION DURING SKELETAL GROWTH AND OSTEOARTHRITIS DEVELOPMENT (2011) (0)
- Corrigendum to “Human genetic studies on osteoarthritis from clinicians’ viewpoints” [Osteoarthritis and Cartilage 2011;19:251–253] (2011) (0)
- Editorial Can Genetic Studies Identify the Target Molecules of Osteoarthritis ? (2016) (0)
- [Bench to bedside of osteoarthritis: where we are and to go]. (2009) (0)
- Transcription factor hes1 modulates osteoarthritis development in cooperation with CaMKII (2014) (0)
- BONE REPRODUCTION AFTER RADIATION THERAPY FOR LONG BONE METASTASIS: A CASE REPORT (2004) (0)
- Prevention and repair of cartilage degeneration by a novel small thienoindazole-derivative compound (2012) (0)
- A4 HYPOXIA-INDUCIBLE FACTOR 2A (HIF2A) CONTROLS SEQUENTIAL STEPS IN THE LATE STAGE OF ENDOCHONDRAL OSSIFICATION (2008) (0)
- Control of Osteoblast Orientation by Means of Strong Magnetic Fields. (2001) (0)
- Medication in Rheumatoid Arthritis (2021) (0)
- Citric Acid-Based Bicarbonate Dialysate Attenuates Aortic Arch Calcification in Maintenance Haemodialysis Patients: An Observational Study (2021) (0)
- Abnormalities in the bone of mouse with a mutation in the klotho locus and its contribution to bone and cartilage diseases (1999) (0)
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What Schools Are Affiliated With Hiroshi Kawaguchi?
Hiroshi Kawaguchi is affiliated with the following schools:
