Hiroshi Shimizu
#177,050
Most Influential Person Now
Researcher
Hiroshi Shimizu's AcademicInfluence.com Rankings
Hiroshi Shimizucomputer-science Degrees
Computer Science
#11027
World Rank
#11636
Historical Rank
Machine Learning
#5034
World Rank
#5096
Historical Rank
Artificial Intelligence
#5426
World Rank
#5500
Historical Rank
Database
#8048
World Rank
#8387
Historical Rank
Download Badge
Computer Science
Hiroshi Shimizu's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
Similar Degrees You Can Earn
Why Is Hiroshi Shimizu Influential?
(Suggest an Edit or Addition)Hiroshi Shimizu's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. (2009) (217)
- Identification of target genes conferring ethanol stress tolerance to Saccharomyces cerevisiae based on DNA microarray data analysis. (2007) (195)
- Comprehensive phenotypic analysis of single‐gene deletion and overexpression strains of Saccharomyces cerevisiae (2011) (126)
- Transcriptome analysis of parallel-evolved Escherichia coli strains under ethanol stress (2010) (121)
- Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum (2009) (119)
- Differential importance of trehalose accumulation in Saccharomyces cerevisiae in response to various environmental stresses. (2010) (105)
- Beer volatile compounds and their application to low-malt beer fermentation. (2008) (102)
- Flux analysis and metabolomics for systematic metabolic engineering of microorganisms. (2013) (100)
- Adaptation of Saccharomyces cerevisiae Cells to High Ethanol Concentration and Changes in Fatty Acid Composition of Membrane and Cell Size (2008) (94)
- OpenMebius: An Open Source Software for Isotopically Nonstationary 13C-Based Metabolic Flux Analysis (2014) (87)
- Enhanced kefiran production by mixed culture of Lactobacillus kefiranofaciens and Saccharomyces cerevisiae. (2003) (86)
- Recent advances in amino acid production by microbial cells. (2016) (83)
- Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis (2007) (79)
- Integrated metabolic flux and omics analysis of Synechocystis sp. PCC 6803 under mixotrophic and photoheterotrophic conditions. (2014) (79)
- Nisin Production by a Mixed-Culture System Consisting of Lactococcus lactis andKluyveromyces marxianus (1999) (77)
- Interactions between Lactobacillus kefiranofaciens and Saccharomyces cerevisiae in mixed culture for kefiran production. (2003) (75)
- Optimal production of glutathione by controlling the specific growth rate of yeast in fed‐batch culture (1991) (75)
- Effect of amino acids on glutathione production by Saccharomyces cerevisiae (2004) (74)
- Comparative analysis of transcriptional responses to saline stress in the laboratory and brewing strains of Saccharomyces cerevisiae with DNA microarray (2006) (74)
- Distinct roles of two anaplerotic pathways in glutamate production induced by biotin limitation in Corynebacterium glutamicum. (2008) (73)
- Effects of the changes in enzyme activities on metabolic flux redistribution around the 2-oxoglutarate branch in glutamate production by Corynebacterium glutamicum (2003) (72)
- Effect of trehalose accumulation on response to saline stress in Saccharomyces cerevisiae (2009) (71)
- An on-line physiological state recognition system for the lysine fermentation process based on a metabolic reaction model. (1997) (68)
- Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli (2014) (64)
- An algorithmic approach to constructing the on‐line estimation system for the specific growth rate (1989) (64)
- Pyruvic acid production by an F1-ATPase-defective mutant of Escherichia coli W1485lip2. (1994) (62)
- Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria. (2005) (62)
- Reconstruction and verification of a genome-scale metabolic model for Synechocystis sp. PCC6803 (2011) (62)
- Cysteine addition strategy for maximum glutathione production in fed-batch culture of Saccharomyces cerevisiae (1992) (61)
- Effect of odhA overexpression and odhA antisense RNA expression on Tween-40-triggered glutamate production by Corynebacterium glutamicum (2009) (61)
- Integrated transcriptomic and metabolomic analysis of the central metabolism of Synechocystis sp. PCC 6803 under different trophic conditions. (2013) (60)
- Fuzzy control of ethanol concentration its application to maximum glutathione production in yeast fed‐batch culture (1993) (58)
- Production of Glutamate and Glutamate-Related Amino Acids: Molecular Mechanism Analysis and Metabolic Engineering (2006) (56)
- Characterization of new isolated Ralstoniaeutropha strain A-04 and kinetic study of biodegradable copolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate) production (2008) (56)
- Requirement of de novo synthesis of the OdhI protein in penicillin-induced glutamate production by Corynebacterium glutamicum (2010) (56)
- Engineering strategy of yeast metabolism for higher alcohol production (2011) (52)
- Metabolic engineering--integrating methodologies of molecular breeding and bioprocess systems engineering. (2002) (49)
- Investigating the effects of perturbations to pgi and eno gene expression on central carbon metabolism in Escherichia coli using 13 C metabolic flux analysis (2012) (49)
- Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer (2016) (49)
- An improved physico-chemical model of hybridization on high-density oligonucleotide microarrays (2008) (48)
- Pyruvic acid production by a lipoic acid auxotroph of Escherichia coliW1485 (1994) (47)
- Modelling and optimization of environmental conditions for kefiran production by Lactobacillus kefiranofaciens (2001) (46)
- Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae. (2012) (45)
- Analysis of adaptation to high ethanol concentration in Saccharomyces cerevisiae using DNA microarray (2009) (44)
- Metabolic engineering of Saccharomyces cerevisiae to improve succinic acid production based on metabolic profiling (2014) (44)
- Optimization of agitation and aeration conditions for maximum virginiamycin production (1999) (41)
- Combinatorial deletions of glgC and phaCE enhance ethanol production in Synechocystis sp. PCC 6803. (2016) (41)
- FastPros: screening of reaction knockout strategies for metabolic engineering (2013) (40)
- Comparison of transcriptional responses to osmotic stresses induced by NaCl and sorbitol additions in Saccharomyces cerevisiae using DNA microarray. (2006) (39)
- Kinetic study of poly-D(-)-3-hydroxybutyric acid (PHB) production and its molecular weight distribution control in a fed batch culture of Alcaligenes eutrophus (1993) (39)
- Metabolic flux control analysis of branch points: an improved approach to obtain flux control coefficients from large perturbation data. (2004) (38)
- Image analysis of mycelial morphology in virginiamycin production by batch culture of Streptomyces virginiae (1996) (38)
- 13C-metabolic flux analysis for mevalonate-producing strain of Escherichia coli. (2017) (38)
- Maximizing yellow pigment production in fed-batch culture of Monascus sp. (2000) (38)
- Metabolic engineering of Synechocystis sp. PCC 6803 for enhanced ethanol production based on flux balance analysis (2017) (36)
- Clustering gene expression pattern and extracting relationship in gene network based on artificial neural networks. (2003) (34)
- Maximum production strategy for biodegradable copolymer P(HB-co-HV) in fed-batch culture of Alcaligenes eutrophus. (1999) (34)
- Investigation of phosphorylation status of OdhI protein during penicillin- and Tween 40-triggered glutamate overproduction by Corynebacterium glutamicum (2011) (33)
- Metabolic Flux Analysis of the Synechocystis sp. PCC 6803 ΔnrtABCD Mutant Reveals a Mechanism for Metabolic Adaptation to Nitrogen-Limited Conditions. (2017) (33)
- Metabolomic analysis of acid stress response in Saccharomyces cerevisiae. (2015) (32)
- Development of an Automated Culture System for Laboratory Evolution (2014) (32)
- Genome-wide expression analysis of Saccharomyces pastorianus orthologous genes using oligonucleotide microarrays. (2010) (32)
- Identification of alcohol stress tolerance genes of Synechocystis sp. PCC 6803 using adaptive laboratory evolution (2017) (32)
- Phenotypic convergence in bacterial adaptive evolution to ethanol stress (2014) (31)
- Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB. (2014) (31)
- Prediction of Cross-resistance and Collateral Sensitivity by Gene Expression profiles and Genomic Mutations (2017) (30)
- Extracting the hidden features in saline osmotic tolerance in Saccharomyces cerevisiae from DNA microarray data using the self-organizing map: biosynthesis of amino acids (2007) (30)
- Application of a mathematical model and Differential Evolution algorithm approach to optimization of bacteriocin production by Lactococcus lactis C7 (2005) (30)
- 13 C-metabolic flux analysis in heterologous cellulase production by Bacillus subtilis genome-reduced strain. (2014) (30)
- Mining of biological data II: assessing data structure and class homogeneity by cluster analysis. (2000) (30)
- Physiological analysis of yeast cells by flow cytometry during serial-repitching of low-malt beer fermentation. (2007) (29)
- Evaluating 13C enrichment data of free amino acids for precise metabolic flux analysis (2011) (29)
- Utilization of Saccharomyces cerevisiae recombinant strain incapable of both ethanol and glycerol biosynthesis for anaerobic bioproduction (2013) (28)
- Optimal Production of Glutathione by Controlling the Specific Growth Rate of Yeast in Fed-Batch Culture (1991) (27)
- On‐line state recognition in a yeast fed‐batch culture using error vectors (1995) (27)
- Absolute quantitation of glycolytic intermediates reveals thermodynamic shifts in Saccharomyces cerevisiae strains lacking PFK1 or ZWF1 genes. (2015) (27)
- Saccharomyces cerevisiae and DNA microarray analyses: what did we learn from it for a better understanding and exploitation of yeast biotechnology? (2010) (27)
- Optimum autoregulator addition strategy for maximum virginiamycin production in batch culture of Streptomyces virginiae (1995) (27)
- Optogenetic switch for controlling the central metabolic flux of Escherichia coli. (2019) (27)
- A Vector Library for Silencing Central Carbon Metabolism Genes with Antisense RNAs in Escherichia coli (2013) (27)
- Mining of biological data I: identifying discriminating features via mean hypothesis testing. (2000) (23)
- Systems metabolic engineering: the creation of microbial cell factories by rational metabolic design and evolution. (2013) (23)
- Improving protein secretion of a transglutaminase-secreting Corynebacterium glutamicum recombinant strain on the basis of 13C metabolic flux analysis. (2011) (23)
- Construction of a Genome-Scale Metabolic Model of Arthrospira platensis NIES-39 and Metabolic Design for Cyanobacterial Bioproduction (2015) (23)
- Application of adaptive laboratory evolution to overcome a flux limitation in an Escherichia coli production strain (2018) (22)
- Transomics data-driven, ensemble kinetic modeling for system-level understanding and engineering of the cyanobacteria central metabolism. (2019) (22)
- In silico screening of triple reaction knockout Escherichia coli strains for overproduction of useful metabolites. (2013) (22)
- Bioprocess Fault Detection by Nonlinear Multivariate Analysis: Application of an Artificial Autoassociative Neural Network and Wavelet Filter Bank (1998) (22)
- ¹³C-based metabolic flux analysis of Saccharomyces cerevisiae with a reduced Crabtree effect. (2015) (22)
- Understanding the mechanism of heat stress tolerance caused by high trehalose accumulation in Saccharomyces cerevisiae using DNA microarray. (2012) (22)
- High-yielding rice Takanari has superior photosynthetic response to a commercial rice Koshihikari under fluctuating light (2019) (22)
- On-line fault diagnosis for optimal rice α-amylase production process of a temperature-sensitive mutant of Saccharomyces cerevisiae by an autoassociative neural network (1997) (21)
- (13)C-metabolic flux analysis in S-adenosyl-L-methionine production by Saccharomyces cerevisiae. (2015) (21)
- Maximum virginiamycin production by optimization of cultivation conditions in batch culture with autoregulator addition (2000) (21)
- A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae (2018) (21)
- An in silico platform for the design of heterologous pathways in nonnative metabolite production (2012) (21)
- Proteomic analysis of responses to osmotic stress in laboratory and sake-brewing strains of Saccharomyces cerevisiae (2009) (21)
- Magnesium starvation improves production of malonyl-CoA-derived metabolites in Escherichia coli. (2019) (21)
- Metabolic engineering of isopropyl alcohol‐producing Escherichia coli strains with 13C‐metabolic flux analysis (2017) (21)
- Precise metabolic flux analysis of coryneform bacteria by gas chromatography-mass spectrometry and verification by nuclear magnetic resonance. (2006) (20)
- Mole fraction control of poly(3-hydroxybutyric-co-3-hydroxyvaleric) acid in fed-batch culture of Alcaligenes eutrophus (1996) (20)
- Learning from quantitative data to understand central carbon metabolism. (2017) (20)
- Improvement of L-Lactate Production by CYB2 Gene Disruption in a Recombinant Saccharomyces cerevisiae Strain under Low pH Condition (2008) (20)
- Multivariable control of alcohol concentrations in the production of polyhydroxyalkanoates (PHAs) by Paracoccus denitrificans. (2001) (20)
- Molecular mechanisms and metabolic engineering of glutamate overproduction in Corynebacterium glutamicum. (2012) (19)
- Metabolome analysis of Saccharomyces cerevisiae and optimization of culture medium for S-adenosyl-l-methionine production (2016) (19)
- Metabolic impact of nutrient starvation in mevalonate-producing Escherichia coli. (2017) (19)
- On-line monitoring of fungal cell concentration by dielectric spectroscopy (1999) (19)
- Simultaneous control of apparent extract and volatile compounds concentrations in low-malt beer fermentation (2006) (19)
- Model-based analysis of non-specific binding for background correction of high-density oligonucleotide microarrays (2009) (19)
- Transcriptome analysis of the cyanobacterium Synechocystis sp. PCC 6803 and mechanisms of photoinhibition tolerance under extreme high light conditions. (2018) (19)
- Reliable Metabolic Flux Estimation in Escherichia coli Central Carbon Metabolism Using Intracellular Free Amino Acids (2014) (18)
- Metabolic engineering of mevalonate-producing Escherichia coli strains based on thermodynamic analysis. (2018) (18)
- Effect of malic enzyme on ethanol production by Synechocystis sp. PCC 6803. (2015) (18)
- Pyruvic acid production by a lipoic acid auxotroph of Escherichia coliW1485 (2004) (17)
- Targeted proteome analysis of single-gene deletion strains of Saccharomyces cerevisiae lacking enzymes in the central carbon metabolism (2017) (17)
- Metabolic Flux Analysis of the Synechocystis sp. PCC 6803 &Dgr;nrtABCD Mutant Reveals a Mechanism for Metabolic Adaptation to Nitrogen-Limited Conditions (2017) (17)
- Data preprocessing and output evaluation of an autoassociative neural network model for online fault detection in virginiamycin production. (2002) (17)
- Investigating the effectiveness of DNA microarray analysis for identifying the genes involved in l-lactate production by Saccharomyces cerevisiae (2009) (16)
- Effect of Carbon and Nitrogen Additions on Consumption Activity of Apparent Extract of Yeast Cells in a Brewing Process (2002) (16)
- Production of Poly-3-Hydroxybutyric Acid (PHB) by Alcaligenes Eutrophus H16 in a Fed-Batch Culture (1992) (16)
- Dynamic change in promoter activation during lysine biosynthesis in Escherichia coli cells. (2008) (15)
- Model predictive controller for biodegradable polyhydroxyalkanoate production in fed-batch culture. (2002) (15)
- Heterologous expression of bacterial phosphoenol pyruvate carboxylase and Entner-Doudoroff pathway in Saccharomyces cerevisiae for improvement of isobutanol production. (2017) (15)
- Characterization and enzymatic degradation of microbial copolyester P(3HB-co-3HV)s produced by metabolic reaction model-based system (2006) (15)
- Flux balance analysis of cyanobacteria reveals selective use of photosynthetic electron transport components under different spectral light conditions (2019) (15)
- Metabolic flux of the oxidative pentose phosphate pathway under low light conditions in Synechocystis sp. PCC 6803. (2018) (15)
- Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations. (2015) (15)
- Treatment of Retinoblastoma 1–Intact Hepatocellular Carcinoma With Cyclin‐Dependent Kinase 4/6 Inhibitor Combination Therapy (2021) (15)
- Investigation of useful carbon tracers for 13C-metabolic flux analysis of Escherichia coli by considering five experimentally determined flux distributions (2016) (14)
- A maximum production strategy of lysine based on a simplified model derived from a metabolic reaction network. (1999) (14)
- GC-MS/MS survey of collision-induced dissociation of tert-butyldimethylsilyl-derivatized amino acids and its application to 13C-metabolic flux analysis of Escherichia coli central metabolism (2016) (13)
- Nano-scale liquid chromatography coupled to tandem mass spectrometry using the multiple reaction monitoring mode based quantitative platform for analyzing multiple enzymes associated with central metabolic pathways of Saccharomyces cerevisiae using ultra fast mass spectrometry. (2015) (13)
- Light‐inducible flux control of triosephosphate isomerase on glycolysis in Escherichia coli (2019) (13)
- Computational prediction of impact of rerouting the carbon flux in metabolic pathway on cell growth and nisin production by Lactococcus lactis (2006) (13)
- Comparative Targeted Proteomics of the Central Metabolism and Photosystems in SigE Mutant Strains of Synechocystis sp. PCC 6803 (2018) (13)
- SSDesign: Computational metabolic pathway design based on flux variability using elementary flux modes (2015) (12)
- Sugar phosphate analysis with baseline separation and soft ionization by gas chromatography-negative chemical ionization-mass spectrometry improves flux estimation of bidirectional reactions in cancer cells. (2019) (12)
- Enhanced kefiran production by mixed culture of and (2003) (12)
- 13C-metabolic flux analysis of ethanol-assimilating Saccharomyces cerevisiae for S-adenosyl-l-methionine production (2018) (12)
- Classification of fermentation performance by multivariate analysis based on mean hypothesis testing. (2002) (12)
- Kinetic modeling of kefiran production in mixed culture of Lactobacillus kefiranofaciens and Saccharomyces cerevisiae (2007) (12)
- On-line estimation and control of apparent extract concentration in low-malt beer fermentation (2005) (12)
- High-yielding rice Takanari has superior photosynthetic response under fluctuating light to a commercial rice Koshihikari. (2019) (12)
- Mass Spectrometry-Based Method to Study Inhibitor-Induced Metabolic Redirection in the Central Metabolism of Cancer Cells (2018) (11)
- Enhancement of 1,5-diaminopentane production in a recombinant strain of Corynebacterium glutamicum by Tween 40 addition. (2016) (11)
- Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis (2015) (11)
- Comparison of metabolic profiles of yeasts based on the difference of the Crabtree positive and negative. (2019) (11)
- Fragmentation of Dicarboxylic and Tricarboxylic Acids in the Krebs Cycle Using GC-EI-MS and GC-EI-MS/MS (2019) (11)
- Effect of precise control of flux ratio between the glycolytic pathways on mevalonate production in Escherichia coli (2019) (11)
- Assessment of Protein Content and Phosphorylation Level in Synechocystis sp. PCC 6803 under Various Growth Conditions Using Quantitative Phosphoproteomic Analysis (2020) (11)
- DNA microarray analysis onSaccharomyces cerevisiae under high carbon dioxide concentration in fermentation process (2005) (10)
- Glutamic Acid Fermentation: Discovery of Glutamic Acid‐Producing Microorganisms, Analysis of the Production Mechanism, Metabolic Engineering, and Industrial Production Process (2016) (10)
- SIMULATION AND EXPERIMENTAL STUDIES OF THE PROFILE CONTROL OF THE SPECIFIC GROWTH RATE IN A FED-BATCH CULTURE (1985) (10)
- Calculation of optimal trajectories for fermentation processes by genetic algorithm (1993) (10)
- Time-resolved analysis of short term metabolic adaptation at dark transition in Synechocystis sp. PCC 6803. (2019) (9)
- Repression of mitochondrial metabolism for cytosolic pyruvate-derived chemical production in Saccharomyces cerevisiae (2019) (9)
- Robustness of cascade pH and dissolved oxygen control in symbiotic nisin production process system of Lactococcus lactis and Kluyveromyces marxianus. (2006) (9)
- 13C-Metabolic Flux Analysis Reveals Effect of Phenol on Central Carbon Metabolism in Escherichia coli (2019) (9)
- Analysis of hemin effect on lactate reduction in Lactococcus lactis. (2007) (9)
- Flux controlling technology for central carbon metabolism for efficient microbial bio-production. (2020) (8)
- On-line recognition of physiological state in a yeast fed-batch culture (1996) (8)
- Nonisothermal Crystallization Kinetics of Biodegradable Random Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Block One (2003) (8)
- Targeted proteome analysis of microalgae under high-light conditions by optimized protein extraction of photosynthetic organisms. (2019) (8)
- Genome-wide analysis of the effects of location and number of stress response elements on gene expression in Saccharomyces cerevisiae. (2008) (7)
- Systems metabolic engineering for the production of bio-nylon precursor. (2013) (7)
- Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling (2018) (7)
- Profile control of the specific growth rate in fed-batch experiments (1989) (7)
- Prediction of Hopeless Peptides Unlikely to be Selected for Targeted Proteome Analysis (2017) (7)
- Mutations in hik26 and slr1916 lead to high-light stress tolerance in Synechocystis sp. PCC6803 (2021) (6)
- Analysis of metabolic network based on conservation of molecular structure (2009) (6)
- Data science-based modeling of the lysine fermentation process. (2020) (6)
- Method of Corynebacterium glutamicum fermentation time extension with high lysine production rate by leucine addition (1998) (6)
- Transcription Factor ArcA is a Flux Sensor for the Oxygen Consumption Rate in Escherichia Coli. (2020) (6)
- Theophylline-inducible riboswitch accurately regulates protein expression at low level in Escherichia coli (2019) (6)
- Estimation of linear and cyclic electron flows in photosynthesis based on 13C-metabolic flux analysis. (2020) (5)
- Analysis of stochasticity in promoter activation by using a dual-fluorescence reporter system (2009) (5)
- Optogenetic reprogramming of carbon metabolism using light-powering microbial proton pump systems. (2022) (5)
- Roles of glucose and acetate as carbon sources inl-histidine production withBrevibacterium flavum FERM1564 revealed by metabolic flux analysis (2002) (5)
- Effects of mutations of GID protein–coding genes on malate production and enzyme expression profiles in Saccharomyces cerevisiae (2020) (5)
- Development of a Physical Model-Based Algorithm for the Detection of Single-Nucleotide Substitutions by Using Tiling Microarrays (2013) (5)
- Role of type I NADH dehydrogenase in Synechocystis sp. PCC 6803 under phycobilisome excited red light. (2020) (5)
- ArtPathDesign: rational heterologous pathway design system for the production of nonnative metabolites. (2013) (5)
- Responses of different strains of Saccharomyces cerevisiae to osmotic stress (2006) (5)
- Analysis of fluctuation in protein abundance without promoter regulation based on Escherichia coli continuous culture (2007) (5)
- Potential of a Saccharomyces cerevisiae recombinant strain lacking ethanol and glycerol biosynthesis pathways in efficient anaerobic bioproduction (2014) (5)
- Reactor control system in bacterial co‐culture based on fluorescent proteins using an Arduino‐based home‐made device (2021) (5)
- Random Transfer of Ogataea polymorpha Genes into Saccharomyces cerevisiae Reveals a Complex Background of Heat Tolerance (2021) (5)
- Positive effects of proline addition on the central metabolism of wild-type and lactic acid-producing Saccharomyces cerevisiae strains (2016) (4)
- Metabolic pathway recruiting through genomic data analysis for industrial application of Saccharomyces cerevisiae (2007) (4)
- Identification of a rate-limiting step in a metabolic pathway using the kinetic model and in vitro experiment. (2020) (4)
- mfapy: An open-source Python package for 13C-based metabolic flux analysis (2021) (4)
- Design of Superior Cell Factories Based on Systems Wide Omics Analysis (2012) (4)
- Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells (2020) (4)
- Novel allosteric inhibition of phosphoribulokinase identified by ensemble kinetic modeling of Synechocystis sp. PCC 6803 metabolism (2020) (4)
- Genome-wide identification of the targets for genetic manipulation to improve L-lactate production by Saccharomyces cerevisiae by using a single-gene deletion strain collection. (2013) (4)
- Comparative analysis of fermentation and enzyme expression profiles among industrial Saccharomyces cerevisiae strains (2018) (4)
- Measurement of enzyme reaction rates using advanced pH control system: Application of repetitive PF system (1989) (3)
- Analysis of DNA Microarray Data using Self-Organizing Map and Hierarchical Clustering (2004) (3)
- Acceleration of target production in co‐culture by enhancing intermediate consumption through adaptive laboratory evolution (2021) (3)
- Soft-sensor development for monitoring the lysine fermentation process. (2021) (3)
- 17. Glutamic Acid (2014) (3)
- Comparison of Estimation Techniques for a Time-Dependent Parameter in a Metabolic Reaction Model (1996) (3)
- Optimal 13C-labeling of glycerol carbon source for precise flux estimation in Escherichia coli. (2017) (3)
- Recent advances in metabolic engineering-integration of in silico design and experimental analysis of metabolic pathways. (2021) (3)
- Metabolic pathway design for growth-associated phenylalanine production using synthetically designed mutualism (2022) (2)
- Strategy for diversification of industrial application of lactic acid microorganism (1998) (2)
- Database Mining Tools for Bioprocess Analysis (1998) (2)
- Microbial Interaction in a Symbiotic Bioprocess of Lactic Acid Bacterium and Diary Yeast (2006) (2)
- SB-P2 High constitutive trehalose is required for resistance to multiple stresses in Saccharomyces cerevisiae(Section XI Systems Biotechnology/Metabolic Engineering) (2009) (2)
- Fuzzy Control of Ethanol Concentration and its Application to Glutathione Production in Yeast Fed-batch Culture (1992) (2)
- Development of Co-Culture Systems of Lactic Acid Bacteria and Yeasts for Bioproduction (2005) (2)
- Thioredoxin pathway in anabaena sp. PCC 7120: activity of NADPH-thioredoxin reductase C. (2021) (2)
- Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling (2018) (2)
- Metabolic pathway engineering for the non-growth-associated succinate production in Escherichia coli based on flux solution space. (2022) (2)
- Control of Molecular Weight Distribution and Mole Fraction in Poly(-D(−)-3-hydroxyalkanoate) (PHA) Production by Alcaligenes eutrophus (1994) (2)
- A noise-driven mechanism for adaptive growth rate regulation (2008) (2)
- Prediction of rate-limiting reactions for growth-associated production using a constraint-based approach. (2019) (1)
- Expression of Saccharomyces cerevisiae cDNAs to enhance the growth of non-ethanol-producing S. cerevisiae strains lacking pyruvate decarboxylases. (2018) (1)
- An in silico platform for the design of heterologous pathways in nonnative metabolite production (2012) (1)
- Quantification of Data Clusters for Bioprocess Performance Classification via Artificial Neural Networks (1998) (1)
- Proteome analysis of response to different spectral light irradiation in Synechocystis sp. PCC 6803. (2021) (1)
- Reduction of lactate production in Lactococcus lactis, a combined strategy: metabolic engineering by introducing foreign alanine dehydrogenase gene and hemin addition (2007) (1)
- Maximum Production of Glutathione in Fed-batch Culture of Saccharomyces cerevisiae (1989) (1)
- Bacteriocin Production Process by a Mixed Culture System (2001) (1)
- High-throughput laboratory evolution of Escherichia coli under multiple stress environments (2017) (1)
- Mining of Multivariate Temporal Biological Data: A Framework for the Rational Design of Data-Driven Models (2001) (1)
- Constitutive expression of the global regulator AbrB restores the growth defect of a genome-reduced Bacillus subtilis strain and improves its metabolite production (2022) (1)
- Metabolic Control Analysis in Glutamate Synthetic Pathway: Experimental Sensitivity Analysis at a Key Branch Point (2002) (1)
- Quality Control of Polyhydroxyalkanoates in Fed-Batch Culture Based on a Metabolic Reaction Model (2001) (1)
- Developing Interpretation of Intracellular Metabolism of Corynebacterium glutamicum by Using Flux Analysis Technology (2015) (1)
- Bioprocess Database Mining (1997) (1)
- Online Fault Detection in Virginiamycin Production (2002) (1)
- Systems biotechnology of coryneform bacteria (2008) (1)
- Improvement of 2,3-butanediol production by dCas9 gene expression system in Saccharomyces cerevisiae (2022) (1)
- 1P268 Quantitative analysis of Escherichia coli Transcriptome using A Full tiling Microarray(Genome,Poster Presentations) (2007) (0)
- 13C metabolic flux analysis clarifies distinct metabolic phenotypes of cancer cell spheroid mimicking tumor hypoxia. (2022) (0)
- Effects of n-butanol production on metabolism and the photosystem in Synecococcus elongatus PCC 7942 based on metabolic flux and target proteome analyses. (2023) (0)
- Recombineering to homogeneity : Extension of multiplex recombineering to large-scale genome editing (2013) (0)
- Optimal Production of Biodegradable Copolymer, P(HB-co-HV), in Fed-Batch Culture of Alcaligenes eutrophus (1998) (0)
- Logistic Regression-Guided Identification of Cofactor Specificity-Contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties (2022) (0)
- Conversion of Mevalonate to Isoprenol Using Light Energy in Escherichia coli without Consuming Sugars for ATP Supply. (2022) (0)
- Feeding Strategy of Required Components by Metabolic Engineering Approach in a Lysine Production Process (1998) (0)
- 2K11-3 Understanding the Osmotic Tolerance Based on DNA Microarray Data in Saccharomyces cerevisiae : Regulation of Amino Acids Biosynthesis (2004) (0)
- 966 On-line Fuzzy Recognition of Fermentation Performance of an Industrial Fermentation Process (1998) (0)
- Optimization of Dissolved Oxygen Supply Method for Maximum Virginiamycin Production (1998) (0)
- Development of a microfluidic cell culture system for the adaptive laboratory evolution (2022) (0)
- Simultaneous Control of Apparent Extract and Volatile Compounds Concentrations in a Beer Brewing Process (2004) (0)
- 1P402 Heterogeneity of cell population in continuous culture of Escherichia coli(16. Cell-cell communication,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
- 3P-080 Engineering of co-factor balance for higher alcohol production in yeast (2015) (0)
- 3P354 Analysis of the relationship between noise in gene expression and the regulatory sturucture in amino acid biosynthesis pathway(Others,Poster Presentations) (2007) (0)
- Rational Design of Metabolic Pathway Improvement based on DNA Microarray Data in Yeast (2004) (0)
- Modelling, Optimization and Realization of Fed-Batch Culture using the Specific Growth Rate (1991) (0)
- Microorganism having a cycle of fixing carbon dioxide introduced therein (2012) (0)
- Utilization of Saccharomyces cerevisiae recombinant strain incapable of both ethanol and glycerol biosynthesis for anaerobic bioproduction (2013) (0)
- Flux balance analysis of cyanobacteria reveals selective use of photosynthetic electron transport components under different spectral light conditions (2019) (0)
- In Silico Metabolic Pathway Design and 13 C-Based Metabolic Flux Analysis for Bio-Production (2015) (0)
- Gene network Analysis by a Self-Organizing Map and an Artificial Neural Network (2004) (0)
- Cascade pH Control in Antimicrobial Peptide, Nisin, Production Process, Utilizing a Mixed Culture System (1999) (0)
- On-Line Monitoring of Fungal Cell Concentration by Capacitance Probe (1999) (0)
- 2K16-2 Metabolic analysis of lactate dehydrogenase gene deficient mutant in lactic acid bacteria (2004) (0)
- Analysis of lager brewing yeast at low temperature fermentation using DNA microarray (2008) (0)
- 343 Mole Fraction Control of PHA in Fed-Batch Culture of Alcaligenes eutrophus (1995) (0)
- S 1 – S 9 , Result S 1 and S 2 ) A pyruvate carbon flux tugging strategy for increasing 2 , 3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae (2018) (0)
- Maximum Virginiamycin Production Strategy and its Realization in batch Cultivation of Streptomyces virginiae by Autoregulator Addition (1995) (0)
- Aerobic glycolysis in cancer cells supplies ATP while preventing excess metabolic thermogenesis (2021) (0)
- 1P293 Relationship between Metabolic Flux and Preservation of Molecular Structures in Metabolic Network(Mathematical biology, biological rythms, and non-equilibrium phenomena,Oral Presentations) (2007) (0)
- Abstract 40: Metabolic rewiring in Rb deficient cells during cancer progression (2016) (0)
- 1P284 1H1255 Environmental adaptation over multiple time scales : comprehensive expression/mutation analysis of evolved E. coli under ethanol stress(Origin of life & Evolution,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan) (2010) (0)
- Editorial overview: Recent progress in analytical technologies for design-build-test-learn cycle in biotechnology. (2018) (0)
- Metabolic Pathway Recruiting through Modeling of Saccharomyces cerevisiae based on Genomics for Industrial Application (2004) (0)
- 2B09-1 Metabolic flux analysis of Corynebacterium glutamicum by control of odhA gene expression (2006) (0)
- 3N1112 Multi-omics analysis of evolved Escherichia coli strains under ethanol stress revealed slow adaptation dynamics(Protein : Measurement & Analysis, Origin of life & Evolution,The 49th Annual Meeting of the Biophysical Society of Japan) (2011) (0)
- Quantitative expression analysis using oligonucleotide microarrays based on a physico-chemical model (2008) (0)
- Metabolome analysis of Saccharomyces cerevisiae and optimization of culture medium for S-adenosyl-l-methionine production (2016) (0)
- INVERSE METABOLIC ENGINEERING BY INTEGRATION OF MULTIPLE OMICS ANALYSES (2007) (0)
- Theophylline-inducible riboswitch accurately regulates protein expression at low level in Escherichia coli (2019) (0)
- On-line recognition and control of physiological state by computing intelligence in fermentation processes (1997) (0)
- 2G09-2 Modeling of The Nisin Production by Batch Fermentation of Lactococcus lactis subsp. lactis ATCC 11454 and Its Application on Metabolic Pathway Modification (2003) (0)
- Mutations in hik26 and slr1916 lead to high-light stress tolerance in Synechocystis sp. PCC6803 (2021) (0)
- Comprehensive phenotypic analysis of yeast under ethanol stress condition (2008) (0)
- 1E1312 P71 Whole genome resequencing of experimentally evolved Escherichia coli using a next generation sequencer(Genome biology, Bioinformatics,The 49th Annual Meeting of the Biophysical Society of Japan) (2011) (0)
- A model-based analysis method for detection of single-base substitution using resequencing microarrays (2009) (0)
- Analysis of Responses of Complex Bionetworks to Changes in Environmental Conditions (2004) (0)
- Metabolic Systems Analysis at a Key Branch Point of Glutamate Production by Coryneform Bacteria (2004) (0)
- Metabolic Flux Analysis in Two Kinds of Coryneform Bacteria with GC-MS and NMR (2004) (0)
- 572 EFFECT OF CYSTEINE ADDITION ON GLUTATHIONE FERMENTATION BY ___- ___- (1990) (0)
- 1Kp17 Software development for ^ C metabolic flux analysis on mixture of carbon source (2011) (0)
- Analysis of Cell Population Dynamics in Continuous Culture of Escherichia coli (2004) (0)
- Production of virginiamycin by Streptomyces virginiae and measurement of mycelial morphology by image analysis. (1994) (0)
- Simultaneous Control of Apparent Extract and Volatile Compounds Concentrations in Beer Fermentation (2004) (0)
- 13 C-Metabolic Flux Analysis of Central Carbon Metabolism Using GC-MS (2016) (0)
- Analysis of Fluctuation in Gene Expression Based on Continuous Culture System (2006) (0)
- Metabolic flux balance analysis of an industrially useful microorganism Corynebacerium glutamicum by a genome-scale reconstructed model (2008) (0)
- 2P480 Relationship between Evolutionary Dynamics and Preservation of Molecular Structures in Metabolic Network(50. Non-equilibrium and complex system,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
- Metabolic engineering in metabolite overproduction (1998) (0)
- 2Gp21 In silico screening of heterologous pathways for production of nonnative metabolites using genome-metabolic networks information (2012) (0)
- Microorganism having introduced therein carbondioxidfikseringscyklus (2012) (0)
- 1Cp06 Effect of odhA antisense RNA expression on glutamate production in Corynebacterium glutamicum (2008) (0)
- 3P-011 Construction of high-throughput automated experimental evolution system using laboratory automation (2013) (0)
- Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells (2023) (0)
- 1122 Chemical composition distribution of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Produced in fed-batch culture of Paracoccus denitrificans (2000) (0)
- 2Ap10 Systems metabolic engineering : Rational design of microbial cell factories(Bio-Based Production) (2012) (0)
- MN-P20 A model-based analysis method for detection of single-base substitution using resequencing microarrays(Section X Micro/Nano Technology for Analysis and Cell Manipulation) (2009) (0)
- 1P285 Study on phenotypic heterogeneity in adaptation process using continuous culture of E. coli cells(Mathematical biology, biological rythms, and non-equilibrium phenomena,Oral Presentations) (2007) (0)
- SB-K1 Multiomics analyses for identification of important genes under stress conditions in bioprocesses(Section XI Systems Biotechnology/Metabolic Engineering) (2009) (0)
- Analysis of Adaptation of Yeast Cells to a High Osmotic Pressure Stress based on Proteomics (2004) (0)
- 1P-283 Genome wide mutation detection of Eschericia Coli using resequencing microarrays(The 46th Annual Meeting of the Biophysical Society of Japan) (2008) (0)
- Fluctuation-Driven Adaptation and Symbiosis in Cellular Dynamics (2010) (0)
- Omics‐Integrated Approach for Metabolic State Analysis of Microbial Processes (2017) (0)
- 2P-103 Adaptive evolution experiment of Synechocystis sp. PCC 6803 for isobutanol tolerance and whole genome sequencing (2014) (0)
- 1P-296 A dynamic adaptive model of cell population for the emergence of complex ecosystem(The 46th Annual Meeting of the Biophysical Society of Japan) (2008) (0)
- 2P-119 Optimization of experimental design for metabolic flux analysis for Escherichia coli (2015) (0)
- Learning from the Wisdom of the Ecosystem: Novel Control Strategy Exploiting Microbial Interaction in Co-Culture System (2001) (0)
- Functional evaluation of non-oxidative glycolysis in Escherichia coli in the stationary phase under microaerobic conditions. (2023) (0)
- Comparative analysis of fermentation and enzyme expression profiles among industrial Saccharomyces cerevisiae strains (2018) (0)
- SB-O3 Flux balance analysis of Corynebacterium glutamicum using a genome-scale metabolic model(Section XI Systems Biotechnology/Metabolic Engineering) (2009) (0)
- 3P-227 Development of resequcencing algorithm for next generation sequencer based on mate-pair distance(Genome biology:Genome analysis,The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
- 2Ka08 Prediction of metabolic flux profile by genome-scale metabolic model for bioproduction using cyanobacteria (2011) (0)
- Effect of light fluctuations on photosynthesis and metabolic flux in Synechocystis sp. PCC 6803. (2023) (0)
- On-Line Physiological State Recognition and Parameter Estimation in the Metabolic Reaction Model Using Error Vectors (1995) (0)
- Prediction of Cross-resistance and Collateral Sensitivity by Gene Expression profiles and Genomic Mutations (2017) (0)
- Phenotypic convergence in bacterial adaptive evolution to ethanol stress (2015) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Hiroshi Shimizu?
Hiroshi Shimizu is affiliated with the following schools:
