Hirota Fujiki

Q: What Schools Are Affiliated With Hirota Fujiki

Hirota Fujiki is affiliated with the following schools: University of Tokyo, Institute of Science Tokyo, Massachusetts Institute of Technology, Saga University, Tokushima Bunri University, Kyoto University

Hirota Fujiki's AcademicInfluence.com Rankings

Hirota Fujiki

Physics

#5729

World Rank

#7595

Historical Rank

Particle Physics

#262

World Rank

#278

Historical Rank

physics Degrees

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Physics

Hirota Fujiki's Degrees

PhD Physics University of Tokyo
Masters Physics University of Tokyo
Bachelors Physics University of Tokyo

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Hirota Fujiki's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. (1988) (569)
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR (2005) (556)
Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. (1998) (512)
Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity (2005) (393)
Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. (1993) (313)
Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea (1987) (310)
Essential Role of Tumor Necrosis Factor α (TNF-α) in Tumor Promotion as Revealed by TNF-α-deficient Mice (1999) (304)
Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver. (1994) (298)
Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. (1999) (247)
Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters. (1981) (224)
Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. (1992) (216)
Green tea and cancer chemoprevention. (1999) (207)
Green tea: cancer preventive beverage and/or drug. (2002) (201)
A New Function of Green Tea: Prevention of Lifestyle‐related Diseases (2001) (198)
Cancer inhibition by green tea. (1998) (196)
New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. (1987) (193)
In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts. (1990) (189)
Green Tea Extracts for the Prevention of Metachronous Colorectal Adenomas: A Pilot Study (2008) (183)
Inhibitory Effect of (—)‐Epigallocatechin Gallate on Carcinogenesis with N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in Mouse Duodenum (1989) (182)
Mechanisms of Growth Inhibition of Human Lung Cancer Cell Line, PC‐9, by Tea Polyphenols (1997) (180)
Cytoskeletal integrity in interphase cells requires protein phosphatase activity. (1992) (176)
Two stages of cancer prevention with green tea (1999) (176)
Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation. (1993) (173)
Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach. (1995) (171)
Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin. (1984) (165)
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. (1984) (163)
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. (1990) (159)
Anticarcinogenic activity of green tea polyphenols. (1993) (157)
New cancer treatment strategy using combination of green tea catechins and anticancer drugs (2011) (154)
Mechanistic Aspects of Green Tea as a Cancer Preventive: Effect of Components on Human Stomach Cancer Cell Lines (1999) (145)
Anticarcinogenic effects of (-)-epigallocatechin gallate. (1992) (137)
Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice. (1999) (131)
Diarrhetic Shellfish Toxin, Dinophysistoxin‐1, Is a Potent Tumor Promoter on Mouse Skin (1988) (128)
A possible naturally occurring tumor promoter, teleocidin B from Streptomyces. (1979) (128)
Structure-activity relationship within a series of okadaic acid derivatives. (1990) (124)
Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors (1981) (123)
DNA and RNA as New Binding Targets of Green Tea Catechins* (2006) (123)
Mechanistic findings of green tea as cancer preventive for humans. (1999) (122)
Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes. (1992) (121)
Structure‐Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein Phosphatase (1991) (118)
A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression. (1996) (112)
Green tea: Health benefits as cancer preventive for humans. (2005) (107)
Unique features of the okadaic acid activity class of tumor promoters (1999) (101)
Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (−)-epigallocatechin gallate-treated cells (2012) (100)
Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis. (1986) (99)
Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. (1992) (95)
Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells (2018) (94)
Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice (2001) (94)
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase. (1975) (94)
Heterogeneous nuclear ribonucleoprotein B1 as a new marker of early detection for human lung cancers. (1999) (93)
Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. (1994) (92)
New TNF-α Releasing Inhibitors, Geraniin and Corilagin, in Leaves of Acer nikoense, Megusurino-ki (2001) (92)
New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. (2003) (88)
Green tea catechin as a chemical chaperone in cancer prevention. (2008) (87)
Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds (2015) (86)
Apparent "activation" of protein kinases by okadaic acid class tumor promoters. (1989) (86)
Nucleolin on the cell surface as a new molecular target for gastric cancer treatment. (2010) (85)
TNF‐α‐inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells (2008) (85)
A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review. (2000) (81)
Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth (2018) (80)
Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds. (1979) (80)
Helicobacter pylori membrane protein 1: a new carcinogenic factor of Helicobacter pylori. (2001) (79)
Tumor promoters--microcystin-LR, nodularin and TNF-α and human cancer development. (2011) (77)
Stimulation of prostaglandin E2 production by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters in macrophages and its inhibition by cycloheximide. (1985) (76)
Phosphoethanolamine as a growth factor of a mammary carcinoma cell line of rat. (1979) (76)
Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin‐dependent kinase 4 proteins due to overexpression of TIS21 (1998) (75)
Primary Cancer Prevention by Green Tea, and Tertiary Cancer Prevention by the Combination of Green Tea Catechins and Anticancer Compounds (2015) (75)
Japanese green tea as a cancer preventive in humans. (2009) (73)
Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1. (2001) (73)
Two significant aspects of microcystin-LR: specific binding and liver specificity. (1994) (73)
New Role of (−)-Epicatechin in Enhancing the Induction of Growth Inhibition and Apoptosis in Human Lung Cancer Cells by Curcumin (2010) (71)
Purification and characterization of pepsinogens and a unique pepsin from rat stomach. (1980) (71)
Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis. (1982) (70)
Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia. (2001) (70)
Epithelial–mesenchymal transition in human gastric cancer cell lines induced by TNF‐α‐inducing protein of Helicobacter pylori (2014) (68)
Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin. (1986) (68)
Apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and DNA damage inducible genes 45 and 153". (2010) (67)
Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomach. (2006) (67)
Discrete roles of cytokines, TNF-α, IL-1, IL-6 in tumor promotion and cell transformation (2002) (66)
Lyngbyatoxins B and C, two new irritants from Lyngbya majuscula. (1990) (66)
Codon 61 Mutations in the c‐Harvey‐ras Gene in Mouse Skin Tumors Induced by 7,12‐Dimethylbenz[a]anthracene Plus Okadaic Acid Class Tumor Promoters (1989) (65)
Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene (2006) (64)
Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter. (1993) (64)
Induction of nuclear factor-kappa B and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A. (1990) (64)
Specific binding ofadaic acid, a new tumor promoter in mouse skin (1989) (64)
Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-α expression (2000) (64)
Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid. (1991) (64)
New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression (2005) (63)
Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis. (1986) (63)
An alternative theory of tissue specificity by tumor promotion of okadaic acid in glandular stomach of SD rats. (1992) (63)
Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2a, from the marine sponge discodermia calyx (1991) (62)
Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation. (1998) (62)
Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori. (2012) (62)
Absolute configuration oOf lyngbyatoxin A (teleocidin A-1) and teleocidin A-2 (1986) (62)
A new tumor-promoting agent, dihydroteleocidin B, markedly enhances chemically induced malignant cell transformation. (1982) (60)
Hyperphosphorylation of N‐60, a protein structurally and immunologically related to nucleolin after tumour‐promoter treatment. (1988) (59)
Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression. (1996) (59)
Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development? (1992) (58)
Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors. (2009) (58)
Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori (2010) (58)
Role of flavonoids in suppressing the enhancement of phospholipid metabolism by tumor promoters. (1983) (57)
Penta-O-Galloyl-β-D-Glucose and (-)-Epigallocatechin Gallate: Cancer Preventive Agents (1992) (57)
Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention. (2012) (57)
Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands (2014) (57)
Modulation of gene expression by (-)-epigallocatechin gallate in PC-9 cells using a cDNA expression array. (2001) (56)
Production of antibodies and development of a radioimmunoassay for okadaic acid. (1988) (56)
Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. (1990) (56)
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis (2004) (55)
Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism. (1983) (55)
Tumor promoters: from chemicals to inflammatory proteins (2013) (54)
Mechanism-based inhibition of cancer metastasis with (-)-epigallocatechin gallate. (2014) (53)
Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages (1988) (53)
Tumor necrosis factor-alpha, a new tumor promoter, engendered by biochemical studies of okadaic acid. (1994) (52)
Estimation of tumor promoting activity and structure-function relationships of aplysiatoxins. (1984) (49)
Disaccharide Esters Screened for Inhibition of Tumor Necrosis Factor‐α Release Are New Anti‐cancer Agents (1999) (49)
Expression of the tumor necrosis factorα gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes (2005) (48)
Helicobacter pylori-secreting protein Tipα is a potent inducer of chemokine gene expressions in stomach cancer cells (2007) (48)
Okadaic acid and phorbol esters: comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitro. (1990) (48)
Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate (2017) (48)
A new tumor promotion pathway and its inhibitors. (1994) (47)
The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters. (1982) (46)
Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum). (2003) (46)
Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes (1992) (46)
Mechanisms of action of okadaic acid class tumor promoters on mouse skin. (1991) (45)
The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression. (1989) (45)
Inhibition of tumor promotion by flavonoids. (1986) (44)
New classes of environmental tumor promoters: indole alkaloids and polyacetates. (1983) (44)
Promotion of BALB/3T3 Cell Transformation by the Okadaic Acid Class of Tumor Promoters, Okadaic Acid and Dinophysistoxin‐1 (1991) (44)
Inhibition by quercetin of the promoting effect of teleocidin on skin papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene. (1984) (43)
Stimulation of arachidonic acid metabolism by different types of tumor promoters. (1985) (43)
Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression. (2000) (42)
Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand. (1987) (42)
The effect of norharman on the metabolism of benzo[alpha]pyrene by rat-liver microsomes in vitro in relation to its enhancement of the mutagenicity of benzo[alpha]pyrene. (1978) (42)
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor. (1990) (41)
Enhanced incorporation of radioactive inorganic phosphate into phospholipids of HeLa cells by tumor promoters. (1983) (41)
Aggregation of human lymphoblastoid cells by tumor-promoting phorbol esters and dihydroteleocidin B. (1980) (40)
Flat reversion by okadaic acid of raf and ret-II transformants. (1989) (40)
Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin. (1990) (39)
第3類の新規しゅよう促進剤,ポリアセタート(デブロモアプリシアトキシンおよびアプリシアトキシン)のしゅよう促進効果に関与する生物効果の分化 (1982) (39)
A blue-green alga from Okinawa contains aplysiatoxins, the third class of tumor promoters. (1985) (39)
Activation of the EBV‐cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin a, aplysiatoxin and debromoaplysiatoxin (1983) (39)
Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin. (2017) (38)
Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins (2016) (38)
Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters. (1989) (38)
Challenging the effectiveness of green tea in primary and tertiary cancer prevention (2012) (38)
Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara. (1992) (37)
A two-stage mouse skin carcinogenesis study of lyngbyatoxin A (2004) (36)
Comparative studies of lactate dehydrogenases in lactic acid bacteria. Amino-acid composition of an active-site region and chemical properties of the L-lactate dehydrogenase of Lactobacillus casei, Lactobacillus curvatus, Lactobacillus plantarum, and Lactobacillus acidophilus. (1977) (36)
Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1. (2002) (35)
Induction of epstein‐barr virus by a new tumor promoter, teleocidin, compared to induction by TPA (1981) (35)
Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway. (1989) (35)
Inhibition of protein phosphatases blocks myogenesis by first altering MyoD binding activity. (1992) (35)
Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation. (2002) (35)
Gist of Dr. Katsusaburo Yamagiwa's papers entitled “Experimental study on the pathogenesis of epithelial tumors” (I to VI reports) (2014) (35)
Teleocidin, lyngbyatoxin A and their hydrogenated derivatives, possible tumor promoters, induce terminal differentiation in HL-60 cells. (1981) (35)
Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid. (1987) (35)
The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects. (1993) (34)
Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin. (1983) (33)
Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter. (1987) (33)
Inhibition of protein phosphatase 2A by cantharidin analogues (1996) (33)
New tumor promoters from marine natural products (1990) (32)
Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism. (1982) (32)
Significance of new environmental tumor promoters (1989) (32)
Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation. (1993) (32)
Molecular pathogenesis of interstitial pneumonitis with TNF-alpha transgenic mice. (1998) (32)
Cancer Prevention with Green Tea Polyphenols for the General Population, and for Patients Following Cancer Treatment (2005) (32)
Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins (2007) (31)
Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis. (1992) (31)
Inhibition of methylnitrosourea-induced large bowel cancer development in rats by sarcophytol A, a product from a marine soft coral Sarcophyton glaucum. (1989) (31)
Stimulation of superoxide anion formation by the non-TPA type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils. (1987) (31)
Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669. (1988) (29)
Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. (1992) (29)
Induction of neoplastic progression in Syrian hamster embryo cells treated with protein phosphatase inhibitors. (1993) (29)
Characterization of amylases produced by tumors. (1981) (29)
Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter. (1983) (29)
Rapid purification of protein phosphatase 2A from mouse brain by microcystin‐affinity chromatography (1991) (28)
Significance of Heterogeneous Nuclear Ribonucleoprotein B1 as a New Early Detection Marker for Oral Squamous Cell Carcinoma (1999) (28)
Stimulation of prostaglandin production and choline turnover in HeLa cells by lyngbyatoxin A and dihydroteleocidin B. (1981) (27)
Hyperphosphorylation of cytokeratins by okadaic acid class tumor promoters in primary human keratinocytes. (1993) (27)
Okadaic acid and dinophysistoxin-1, non-TPA-type tumor promoters, stimulate prostaglandin E2 production in rat peritoneal macrophages. (1989) (27)
Activation of Protein Kinase C by Mycobacterial Cord Factor, Trehalose 6‐Monomycolate, Resulting in Tumor Necrosis Factor‐α Release in Mouse Lung Tissues (1995) (26)
The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers (2018) (26)
Effects of tumor promoters on the frequency of metallothionein I gene amplification in cells exposed to cadmium. (1983) (26)
A radioimmunoassay for palytoxin. (1988) (26)
Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin. (1984) (25)
Tumor promotion and TNF‐α gene expression by the okadaic acid class tumor promoters (1997) (25)
Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin. (1989) (24)
DNA-binding activity of TNF-α inducing protein from Helicobacter pylori (2007) (24)
Inhibition of pkc and pka by chemopreventive organoselenium compounds. (1995) (24)
Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. (1997) (24)
Purification and Properties of the NAD+: Protein ADP‐ribosyltransferase Responsible for the T4‐Phage‐Induced Modification of the œ Subunit of DNA‐Dependent RNA Polymerase of Escherichia coli (1977) (24)
Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway. (1992) (23)
Interaction between quercetin and Ca2+-calmodulin complex: possible mechanism for anti-tumor-promoting action of the flavonoid. (1984) (23)
Involvement of TNF-α changes in human cancer development, prevention and palliative care (2002) (22)
Distinct inhibitory effects of dihydroteleocidin B and the phorbol ester tumor promoters on the adipocyte differentiation of 3T3-L1 cells. (1983) (22)
New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. (2001) (22)
Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages. (1990) (22)
Purificaton and characterization of a pepsinogen and its pepsin from proventriculus of the Japanese quail. (1980) (22)
A combination of palytoxin with 1-oleoyl-2-acetyl-glycerol (OAG) or insulin or interleukin-1 synergistically stimulates arachidonic acid metabolism, but combinations of 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters with OAG do not. (1986) (21)
Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin. (1990) (21)
Inhibitory Effect of Sarcophytol A on Development of Spontaneous Hepatomas in Mice (1991) (21)
Production of antibodies to palytoxin: neutralization of several biological properties of palytoxin. (1987) (20)
Morusin, isolated from root bark of Moms alba L., inhibits tumour promotion of teleocidin (1989) (20)
New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B. (1990) (20)
Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin. (1984) (20)
Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility. (1992) (19)
Green tea and cancer prevention (2002) (19)
Sarcophytols A and B inhibit tumor promotion by teleocidin in two-stage carcinogenesis in mouse skin (2004) (19)
Resiniferonol-related Diterpene Esters from Daphne odora Thunb. and their Ornithine Decarboxylase-inducing Activity in Mouse Skin (1982) (19)
Echinoclasterol sulfate phenethylammonium salt, a unique steroid sulfate from the marine sponge, Echinoclathria subhispida (1993) (19)
Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters. (1986) (19)
Morphological Changes of Human Myeloid Leukemia K562 Cells by a Protein Phosphatase Inhibitor, Tautomycin (1990) (19)
Differential effects of cryptoporic acids D and E, inhibitors of superoxide anion radical release, on tumor promotion of okadaic acid in mouse skin. (1991) (18)
Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7-O-(4-azidobenzoyl)okadaate. (1990) (18)
Carcinogenic potential of tobacco tar-resistant Staphylococcus aureus in buccal cavity (2004) (18)
Stimulation of histamine release and arachidonic acid metabolism in rat peritoneal mast cells by thapsigargin, a non-TPA-type tumor promoter. (1989) (17)
Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro. (1988) (17)
Chemistry and anti-tumor promoting activity of Morus flavonoids. (1988) (17)
Teleocidin: new naturally occurring tumor promoter. (1982) (17)
Association of MTG8 (ETO/CDR), a Leukemia‐related Protein, with Serine/Threonine Protein Kinases and Heat Shock Protein HSP90 in Human Hematopoietic Cell Lines (1999) (17)
Combinations of palytoxin or 12-O-tetradecanoylphorbol-13-acetate and recombinant human insulin growth factor-I or insulin synergistically stimulate prostaglandin production in cultured rat liver cells and squirrel monkey aorta smooth muscle cells. (1986) (17)
Induction of supermelanin synthesis and morphological changes in interspecific reconstituted cells and its reversal by tumor promoter (1982) (17)
Similar, potent tumor-promoting activity of all isomers of teleocidins A and B in a two-stage carcinogenesis experiment on the skin of CD-1 mice. (1988) (16)
Tumor Promoting Activities of New Synthetic Analogues of Teleocidin (1985) (16)
Palytoxin: an extraordinarily potent stimulator of prostaglandin production and bone resorption in cultured mouse calvariae. (1987) (16)
Protection of 5α‐dihydrotestosterone against TGF‐β‐induced apoptosis in FaO cells and induction of mitosis in HepG2 cells (1997) (16)
Mouse 3T3-L1 cell variants unable to respond to mitogenic stimulation of dihydroteleocidin B: genetic evidence for the synergism of tumor promoters with growth factors. (1986) (15)
Binding studies of [3H]lyngbyatoxin A and [3H]debromoaplysiatoxin to the phorbol ester receptor in a mouse epidermal particulate fraction. (1986) (15)
Enhancement of Epstein-Barr virus-induced transformation of human lymphocytes by teleocidin. (1981) (15)
Increased phosphorylation of nuclear phosphoproteins in human lung‐cancer cells resistant to cis‐diamminedichloroplatinum(II) (1992) (15)
Comparison of 12-O-tetradecanoylphorbol-13-acetate and teleocidin for induction of epidermal hyperplasia, activation of epidermal PKC isozymes and skin tumor promotion in SENCAR and C57BL/6 mice. (1993) (15)
Increase in the synthesis of a Mr 32,000 protein in BALB/c 3T3 cells treated with tumor-promoting indole alkaloids or polyacetates. (1983) (15)
An alternative computer model of the 3-dimensional structural of microcystin-LR and nodularin rationalising their interactions with protein phosphatases 1 and 2A (1992) (15)
Lysis of human immunodeficiency virus infected cells by TPA-type and non-TPA type tumor promoters. (1988) (15)
Delayed induction of ornithine decarboxylase in mouse skin after irradiation with beta-rays. (1982) (15)
Pendolmycin, a New Tumor Promoter of the Teleocidin A Class on Skin of CD‐1 Mice (1991) (14)
Modulation of phorbol ester receptors in mouse skin by application of quercetin. (1986) (14)
Nakahara memorial lecture. New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. (1983) (14)
Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring (1996) (14)
Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein. (2009) (14)
Tumourigenicity of MTG8, a leukaemia‐related gene, in concert with v‐Ha‐ras gene in BALB/3T3 cells (1998) (14)
Inhibition of intercellular communication in Chinese hamster V79 cells by teleocidin. (1982) (14)
The structures of additional teleocidin class tumor promoters. (1986) (14)
Sarcophytols and Protease Inhibitors Suppress H2O2 Formation and Oxidative DNA Damage (1991) (13)
Involvement of TNF-alpha changes in human cancer development, prevention and palliative care. (2002) (13)
Separation of Two Kinds of Polymerase from Alcaligenes faecalis* (1966) (13)
Analysis of tumor-promoter-induced inflammation in rats: participation of histamine and prostaglandin E2. (1987) (12)
Significance of MTG8 in leukemogenesis. (1997) (12)
Involvement of sulfatide in activation of protein kinase C by tumor promoters. (1986) (12)
A rapid, simple screening method for skin-tumor promoters using mouse peritoneal macrophages in vitro. (1984) (11)
Significant Marine Natural Products in Cancer Research (1993) (11)
Induction of histidine decarboxylase activity in mouse skin after application of indole alkaloids, a new class of tumor promoter. (1982) (11)
Phorbol esters in seed oil of Jatropha curcas L. (saboodam in Thai) and their association with cancer prevention: from the initial investigation to the present topics (2017) (11)
Diversity in the chemical nature and mechanism of response to tumor promoters. (1989) (11)
Tumor promoter-dependent mouse leukemia cell line. (1983) (11)
Sarcophytol A and Its Analogs: Cancer Preventive Activity (1992) (10)
A new pathway of tumor promotion by the okadaic acid class compounds. (1990) (10)
[Tumor promotion by inhibitors of protein phosphatase 1 and 2A]. (1998) (10)
Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells. (1989) (10)
Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies (2021) (10)
A new tumor promoter, dihydroteleocidin b, enhances cell growth and the production of murine leukemia virus by fibroblasts (1983) (9)
Effect of TPA on the mutagenicity of caffeine in the soybean mutation test (1983) (9)
Presence of a Motif Conserved between Helicobacter pylori TNF-α Inducing Protein (Tipα) and Penicillin-Binding Proteins (2005) (9)
Naturally-Derived Tumor Promoters and Inhibitors of Carcinogenesis (1996) (9)
Translational research on TNF-alpha as an endogenous tumor promoter and green tea as cancer preventive in humans. (2005) (9)
Tautomycin: An inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach (2005) (9)
DNA-binding activity of TNF-alpha inducing protein from Helicobacter pylori. (2007) (9)
Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter (2004) (8)
Cell transformation induced by bovine papillomavirus DNA as an assay for tumor promoters and chemopreventive agents. (1991) (8)
The role of arginine in interactions of microcystins with protein phosphatases 1 and 2a (1992) (8)
Seminar on Poly(ADP-Ribose) and ADP-ribosylation of Protine (1975) (8)
Existence of an optimal dose of dihydroteleocidin B for skin tumor promotion. (1982) (8)
Innovative strategy of cancer treatment with the combination of green tea catechins and anticancer compounds (2015) (8)
Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate. (2008) (8)
Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin. (1993) (8)
[Chemoprevention of cancer]. (1986) (8)
Teleocidin-induced modulation of growth and cell interaction in microenvironment-dependent mouse leukemias. (1983) (7)
Mechanistic Findings of Green Tea as Cancer Preventive for Humans (1999) (7)
Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages. (1988) (7)
INTERACTION BETWEEN QUERCETIN AND Ca2+-CALMODULIN COMPLEX (1984) (7)
Critical biochemical and regulatory events in malignant transformation in vitro. (1983) (7)
Identification of a mutation within the structural gene for the a subunit of DNA-dependent RNA polymerase of E. coli (1976) (7)
Calyculins E, F, G, and H, Additional Inhibitors of Protein Phosphatases 1 and 2A, from the Marine Sponge Discodermia calyx. (1991) (7)
Effect of Tumor Promoters in Relation to the Cell Membrane (1983) (6)
Structural basis for the Helicobacter pylori carcinogenic TNF〈-inducing protein (2011) (6)
Effects of various tumor promoters on expression of cartilage phenotypes in rabbit costal chondrocytes in culture. (1987) (6)
Heterogeneous Nuclear Ribonucleoprotein B 1 as a New Marker of Early Detection for Human Lung Cancers 1 (1999) (5)
A radioimmunoassay for the teleocidins using 26 (2'-aminoethylthio)-tetrahydroteleocidin A-2 as hapten. (1988) (5)
Syntheses of isocitric acid derivatives and biological evaluation (2000) (5)
Significance of the cyanobacterial cyclic peptide toxins, the microcystins and nodularin, in liver cancer (1993) (5)
Identification of a mutation within the structural gene for the α subunit of DNA-dependent RNA polymerase of E. Coli (2004) (5)
Marine natural products against tumor development. (1992) (5)
Tumor promoters may induce the appearance of extrachromosomal circular DNAs in rodent cell lines (1984) (4)
Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin. (1984) (4)
Abstract 2665: Green tea catechin, EGCG, enhances antitumor immunity by down-regulation of PD-L1 expression in non-small human lung cancer cell lines (2017) (4)
U.S.‐Japan Seminar on “Marine Natural Products and Cancer” (1989) (4)
Designing of chimeric DNA/RNA hammerhead ribozymes to be targeted againstAML1/MTG8 mRNA (2005) (4)
Mitogenic and comitogenic properties of the indole alkaloid class of tumor promoters (1984) (4)
Mechanisms of (−)-Epigallocatechin Gallate and Green Tea in Inhibition of Carcinogenesis (1997) (4)
Tumor Antipromoters: Sarcophytols A and B, (–)–Epigallocatechin Gallate (EGCG), and Morusin (1991) (3)
Abstract 4723: Innovative cancer treatment of human lung cancer cells PC-9 with a synthetic retinoid Am80 and EGCG via inhibition of HDAC4 and HDAC5 (2016) (3)
Presence of a motif conserved between Helicobacter pylori TNF-alpha inducing protein (Tipalpha) and penicillin-binding proteins. (2005) (3)
In vitro catalytic activities of DNA/RNA chimeric hammerhead ribozymes against AML1-MTG8 mRNA, a fused gene transcript in acute myeloid leukemia with t(8;21). (1996) (3)
[Case of traumatic fistula of the superficial temporal artery, anterior cerebral artery and superior sagittal sinus]. (1967) (3)
[Inhibitors of protein phosphatases]. (1993) (3)
Induced secretion of a Mr 46,000 protein by cultured human hepatoma cells treated with tumor promoters. (1985) (3)
Protection of 5alpha-dihydrotestosterone against TGF-beta-induced apoptosis in FaO cells and induction of mitosis in HepG2 cells. (1997) (3)
Anti‐tumor Promoting Activity of Canventol and Its Synthetic Analogs through Inhibition of Protein Isoprenylation (1996) (3)
Binding competition of okadaic acid derivatives to anti-okadaic acid antibody. (1991) (3)
Purification and properties of the NAD+: protein ADP-ribosyltransferase responsible for the T4-phage-induced modification of the alpha subunit of DNA-dependent RNA polymerase of Escherichia coli. (1977) (3)
Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene (2004) (2)
Abstract 2640A: Cell stiffness as a new indicator of diagnosis for human lung cancer cells and their metastasis. (2013) (2)
Synergistic Effects of ( 2 )-Epigallocatechin Gallate with ( 2 )-Epicatechin, Sulindac, or Tamoxifen on Cancer-preventive Activity in the Human Lung Cancer Cell Line PC-9 1 (1998) (2)
The seventh Korea–Japan joint symposium on cancer and ageing research: molecular targets in cancer and ageing research (2006) (2)
1.2 – Green Tea as a Cancer Preventive (2000) (2)
Natural Inhibitors of Carcinogenesis (1998) (2)
Twist form of teleocidin derivatives is active in in vivo tumor promotion by (-)-benzolactam-V8-310. (1998) (2)
Advances in Brief Synergistic Effects of ( 2 )-Epigallocatechin Gallate with ( 2 )-Epicatechin , Sulindac , or Tamoxifen on Cancer-preventive Activity in the Human Lung Cancer Cell Line PC-91 (1998) (2)
The unique carcinogenic factor Tipα in cancer microenvironment of H. pylori infection (2007) (2)
Specific binding of [3H]retinoids to cellular retinoid‐binding proteins (1988) (2)
U.S.-JAPAN SEMINAR ON“MARINE NATURAL PRODUCTS AND CANCER CHEMOPREVENTION” (1987) (2)
Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives (2004) (2)
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T 7-induced protein kinase ( transcriptional control / phosphothreonine ) (1)
Increase in frequency of appearance of cadmium-resistant cells induced by various tumor promoters; evidence for the induction of gene amplification. (1983) (1)
Synergistic anticancer activity of EGCG with cancer preventive agents mediated through GADD153 gene expression in human lung cancer cells (2006) (1)
The Seoul Symposium of the Journal of Cancer Research and Clinical Oncology Regulation of aging and carcinogenesis (2000) (1)
Stimulation of arachidonic acid metabolism by a streptococcal preparation (OK-432) in rat peritoneal macrophages. (1992) (1)
Inhibitory effect of sarcophytol a (SaA) on tumor growth of transplanted human pancreatic cancer cell (MIA paca-2) in nude mice (1993) (1)
Distinct responses of 3T3-L1 cells to dihydroteleocidin B and the phorbol ester tumor promoters: relation to adipocyte differentiation, DNA synthesis and cell division. (1983) (1)
[Mechanisms of action of tipa (TNF-alpha inducing protein), a new carcinogenic factor, released from H. pylori]. (2005) (1)
A comparison of the effects of tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin on gene expression in human skin cell fibroblasts. (1984) (1)
Japan-Korea Cancer Research Symposium: investigation on the balanced cooperation of cancer cells with the human body (2001) (1)
[The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion]. (1986) (1)
New approach to lung cancer prevention mediated through up-regulation of GADD153 gene (2008) (1)
Relation between the structures of ingenol esters and their ornithine decarboxylase-inducing activities in mouse skin. (1982) (1)
Heterogeneous Nuclear Ribonucleoprotein B 1 as Early Cancer Biomarker for Occult Cancer of Human Lungs and Bronchial Dysplasia 1 (2001) (1)
Advances in Brief Hyperphosphorylation of Retinoblastoma Protein and p 53 by Okadaic Acid , a Tumor Promoter (2007) (0)
deficient Mice α Promotion as Revealed by TNF-) in Tumor α ( TNF-α Essential Role of Tumor Necrosis Factor Updated (1999) (0)
Abstract 168A: More effective therapy of cancer by the combination of anticancer drugs with green tea catechins. (2013) (0)
Crystal structure of novel carcinogenic factor of H. pylori (2009) (0)
EGCG as a Cancer Chemopreventive Agent. (1993) (0)
Presence of tumor promoters in Jatropha oil of Thailand (1987) (0)
Mechanism of palytoxin action on the epidermal growth factor receptor (1990) (0)
Teleocidin, a tumour promoter, stimulates synthesis of primate retroviruses in persistently infected human cells. (1985) (0)
[Enzymatic study on the biosynthesis of DNA. Required primer of Alcaligenes faecalis DNA polymerase]. (1966) (0)
137. Differentiation control in human breast tumor cells by okadaic acid and related phosphatase inhibitors (1992) (0)
1P019 Crystal structure of the serine protease from Aeromonas sobria (2005) (0)
Symposium on “Retinoid Research and Clinical Application” Supported by the Japanese Cancer Association (1990) (0)
RESISTANCE OF HUMAN BRONCHIAL EPITHELIAL CELLS TO TELEOCIDIN IN A TWO‐STAGE CARCINOGENESIS EXPERIMENT (1987) (0)
Proceedings: Modification of DNA-dependent RNA polymerase. (1975) (0)
Differentiation, early response gene expression, and apoptosis induction in human breast tumor cells by Okadaic Acid and related inhibitors of protein phosphatases 1 and 2A. Okadaic acid effects on human breast tumor cells (1992) (0)
Necrosis Factor Acts as a 1 \ imor Promoter in BALB / 3 T 3 Cell Transformation 1 (2006) (0)
在小鼠組織中一種癌症預防的茶多酚[3H]-EGCG之廣泛性分佈 (2009) (0)
Friendship in research: the Japan–Korea symposia on cancer and ageing (2008) (0)
TNF-α-inducing protein (Tipα), a unique carcinogenic factor secreted from H. pylori, as a new molecular target for gastric cancer prevention (2007) (0)
Syntheses of Isocitric Acid Derivatives and Biological Evaluation. (2000) (0)
Professor Kaichiro Kuroda and Scientific Activity at The Department of Medical Chemistry of Keijo Imperial University in Korea (1930-1941) (2012) (0)
His Imperial Highness Prince Hitachi (1999) (0)
Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A. (2023) (0)
Pd2 SUPERPOSITION OF TELEOCIDINS AND PHORBOL ESTERS BY A NEW COMPUTATIONAL METHOD (1988) (0)
Abstract 561: Role of nucleolin in activation of NF-κB signaling with Tip≤, a carcinogenic factor ofH. pylori (2012) (0)
New aspects of cancer prevention with green tea catechin. (2006) (0)
Structure-Activity Studies of the Nonphorbol Tumor Promoter Palytoxin in Swiss 3 T 3 Cells 1 (2006) (0)
Diet and Cancer Prevention (1998) (0)
Abstract 1476: Cell surface nucleolin acts as a specific receptor of Tipα, a carcinogenic factor released fromH. pylori (2010) (0)
Takeo Wada Cancer Research Symposium in Chiang Mai (2001) (0)
New Biological Significance of Indole-Containing Compounds as Initiators or Tumor Promoters in Chemical Carcinogenesis (1984) (0)
Regulation ofcollagenase gene expression byokadaic acid, an inhibitor ofprotein phosphatases (1990) (0)
[Recent advance of the study of okadaic acid class tumor promoters]. (1993) (0)
Production of antibodies and development of a radioimmunoassay for palytoxin (1990) (0)
Progressive Insight into Tumor Promotion with Pro-inflammatory Cytokines (2015) (0)
Kinase Inhibitor Growth-modulating Agents : Effects of Staurosporine , a Protein Regulation of the Epidermal Growth Factor Receptor by Updated (2006) (0)
Large c-terminal domain of influenza a virus RNA-dependent polymerase PB2 (2009) (0)
Proceedings of the 70th general meeting from march 26–28, 1984 (1985) (0)
Tumor Promoter-dependent Mouse Leukemia Cell Line 1 (2006) (0)
Abstract 1388: Metastatic potential of B16 melanoma subclones indicated by cell stiffness measured by atomic force microscopy (AFM) (2011) (0)
The eleventh Korea–Japan–Germany joint symposium on cancer and ageing research (2013) (0)
Abstract 1143: Induction of epithelial-mesenchymal transition (EMT) in human gastric cancer cell lines induced by Tipα of H. pylori mediated through surface nucleolin (2014) (0)
Alkyl gallates, derived from structural studies of green tea catechins, as new candidates for cancer preventive agents (2007) (0)
Structulal Modifications and Regulational Changes of DNA dependent RNA Polymerase from E. coli (1977) (0)
Abstract 1934: Molecular mechanism of abnormal localization of nucelolin on cell-surface of gastric cancer cells, with regard to Ras signaling pathway (2011) (0)

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