Hirota Fujiki
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Particle Physics
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Physics
Hirota Fujiki's Degrees
- PhD Physics University of Tokyo
- Masters Physics University of Tokyo
- Bachelors Physics University of Tokyo
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(Suggest an Edit or Addition)Hirota Fujiki's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. (1988) (569)
- Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR (2005) (556)
- Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. (1998) (512)
- Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity (2005) (393)
- Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. (1993) (313)
- Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea (1987) (310)
- Essential Role of Tumor Necrosis Factor α (TNF-α) in Tumor Promotion as Revealed by TNF-α-deficient Mice (1999) (304)
- Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver. (1994) (298)
- Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. (1999) (247)
- Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters. (1981) (224)
- Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. (1992) (216)
- Green tea and cancer chemoprevention. (1999) (207)
- Green tea: cancer preventive beverage and/or drug. (2002) (201)
- A New Function of Green Tea: Prevention of Lifestyle‐related Diseases (2001) (198)
- Cancer inhibition by green tea. (1998) (196)
- New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. (1987) (193)
- In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts. (1990) (189)
- Green Tea Extracts for the Prevention of Metachronous Colorectal Adenomas: A Pilot Study (2008) (183)
- Inhibitory Effect of (—)‐Epigallocatechin Gallate on Carcinogenesis with N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in Mouse Duodenum (1989) (182)
- Mechanisms of Growth Inhibition of Human Lung Cancer Cell Line, PC‐9, by Tea Polyphenols (1997) (180)
- Cytoskeletal integrity in interphase cells requires protein phosphatase activity. (1992) (176)
- Two stages of cancer prevention with green tea (1999) (176)
- Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation. (1993) (173)
- Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach. (1995) (171)
- Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin. (1984) (165)
- Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. (1984) (163)
- Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. (1990) (159)
- Anticarcinogenic activity of green tea polyphenols. (1993) (157)
- New cancer treatment strategy using combination of green tea catechins and anticancer drugs (2011) (154)
- Mechanistic Aspects of Green Tea as a Cancer Preventive: Effect of Components on Human Stomach Cancer Cell Lines (1999) (145)
- Anticarcinogenic effects of (-)-epigallocatechin gallate. (1992) (137)
- Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice. (1999) (131)
- Diarrhetic Shellfish Toxin, Dinophysistoxin‐1, Is a Potent Tumor Promoter on Mouse Skin (1988) (128)
- A possible naturally occurring tumor promoter, teleocidin B from Streptomyces. (1979) (128)
- Structure-activity relationship within a series of okadaic acid derivatives. (1990) (124)
- Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors (1981) (123)
- DNA and RNA as New Binding Targets of Green Tea Catechins* (2006) (123)
- Mechanistic findings of green tea as cancer preventive for humans. (1999) (122)
- Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes. (1992) (121)
- Structure‐Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein Phosphatase (1991) (118)
- A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression. (1996) (112)
- Green tea: Health benefits as cancer preventive for humans. (2005) (107)
- Unique features of the okadaic acid activity class of tumor promoters (1999) (101)
- Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (−)-epigallocatechin gallate-treated cells (2012) (100)
- Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis. (1986) (99)
- Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. (1992) (95)
- Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells (2018) (94)
- Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice (2001) (94)
- In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase. (1975) (94)
- Heterogeneous nuclear ribonucleoprotein B1 as a new marker of early detection for human lung cancers. (1999) (93)
- Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. (1994) (92)
- New TNF-α Releasing Inhibitors, Geraniin and Corilagin, in Leaves of Acer nikoense, Megusurino-ki (2001) (92)
- New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. (2003) (88)
- Green tea catechin as a chemical chaperone in cancer prevention. (2008) (87)
- Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds (2015) (86)
- Apparent "activation" of protein kinases by okadaic acid class tumor promoters. (1989) (86)
- Nucleolin on the cell surface as a new molecular target for gastric cancer treatment. (2010) (85)
- TNF‐α‐inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells (2008) (85)
- A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review. (2000) (81)
- Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth (2018) (80)
- Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds. (1979) (80)
- Helicobacter pylori membrane protein 1: a new carcinogenic factor of Helicobacter pylori. (2001) (79)
- Tumor promoters--microcystin-LR, nodularin and TNF-α and human cancer development. (2011) (77)
- Stimulation of prostaglandin E2 production by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters in macrophages and its inhibition by cycloheximide. (1985) (76)
- Phosphoethanolamine as a growth factor of a mammary carcinoma cell line of rat. (1979) (76)
- Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin‐dependent kinase 4 proteins due to overexpression of TIS21 (1998) (75)
- Primary Cancer Prevention by Green Tea, and Tertiary Cancer Prevention by the Combination of Green Tea Catechins and Anticancer Compounds (2015) (75)
- Japanese green tea as a cancer preventive in humans. (2009) (73)
- Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1. (2001) (73)
- Two significant aspects of microcystin-LR: specific binding and liver specificity. (1994) (73)
- New Role of (−)-Epicatechin in Enhancing the Induction of Growth Inhibition and Apoptosis in Human Lung Cancer Cells by Curcumin (2010) (71)
- Purification and characterization of pepsinogens and a unique pepsin from rat stomach. (1980) (71)
- Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis. (1982) (70)
- Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia. (2001) (70)
- Epithelial–mesenchymal transition in human gastric cancer cell lines induced by TNF‐α‐inducing protein of Helicobacter pylori (2014) (68)
- Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin. (1986) (68)
- Apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and DNA damage inducible genes 45 and 153". (2010) (67)
- Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomach. (2006) (67)
- Discrete roles of cytokines, TNF-α, IL-1, IL-6 in tumor promotion and cell transformation (2002) (66)
- Lyngbyatoxins B and C, two new irritants from Lyngbya majuscula. (1990) (66)
- Codon 61 Mutations in the c‐Harvey‐ras Gene in Mouse Skin Tumors Induced by 7,12‐Dimethylbenz[a]anthracene Plus Okadaic Acid Class Tumor Promoters (1989) (65)
- Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene (2006) (64)
- Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter. (1993) (64)
- Induction of nuclear factor-kappa B and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A. (1990) (64)
- Specific binding ofadaic acid, a new tumor promoter in mouse skin (1989) (64)
- Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-α expression (2000) (64)
- Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid. (1991) (64)
- New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression (2005) (63)
- Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis. (1986) (63)
- An alternative theory of tissue specificity by tumor promotion of okadaic acid in glandular stomach of SD rats. (1992) (63)
- Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2a, from the marine sponge discodermia calyx (1991) (62)
- Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation. (1998) (62)
- Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori. (2012) (62)
- Absolute configuration oOf lyngbyatoxin A (teleocidin A-1) and teleocidin A-2 (1986) (62)
- A new tumor-promoting agent, dihydroteleocidin B, markedly enhances chemically induced malignant cell transformation. (1982) (60)
- Hyperphosphorylation of N‐60, a protein structurally and immunologically related to nucleolin after tumour‐promoter treatment. (1988) (59)
- Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression. (1996) (59)
- Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development? (1992) (58)
- Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors. (2009) (58)
- Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori (2010) (58)
- Role of flavonoids in suppressing the enhancement of phospholipid metabolism by tumor promoters. (1983) (57)
- Penta-O-Galloyl-β-D-Glucose and (-)-Epigallocatechin Gallate: Cancer Preventive Agents (1992) (57)
- Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention. (2012) (57)
- Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands (2014) (57)
- Modulation of gene expression by (-)-epigallocatechin gallate in PC-9 cells using a cDNA expression array. (2001) (56)
- Production of antibodies and development of a radioimmunoassay for okadaic acid. (1988) (56)
- Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. (1990) (56)
- Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis (2004) (55)
- Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism. (1983) (55)
- Tumor promoters: from chemicals to inflammatory proteins (2013) (54)
- Mechanism-based inhibition of cancer metastasis with (-)-epigallocatechin gallate. (2014) (53)
- Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages (1988) (53)
- Tumor necrosis factor-alpha, a new tumor promoter, engendered by biochemical studies of okadaic acid. (1994) (52)
- Estimation of tumor promoting activity and structure-function relationships of aplysiatoxins. (1984) (49)
- Disaccharide Esters Screened for Inhibition of Tumor Necrosis Factor‐α Release Are New Anti‐cancer Agents (1999) (49)
- Expression of the tumor necrosis factorα gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes (2005) (48)
- Helicobacter pylori-secreting protein Tipα is a potent inducer of chemokine gene expressions in stomach cancer cells (2007) (48)
- Okadaic acid and phorbol esters: comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitro. (1990) (48)
- Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate (2017) (48)
- A new tumor promotion pathway and its inhibitors. (1994) (47)
- The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters. (1982) (46)
- Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum). (2003) (46)
- Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes (1992) (46)
- Mechanisms of action of okadaic acid class tumor promoters on mouse skin. (1991) (45)
- The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression. (1989) (45)
- Inhibition of tumor promotion by flavonoids. (1986) (44)
- New classes of environmental tumor promoters: indole alkaloids and polyacetates. (1983) (44)
- Promotion of BALB/3T3 Cell Transformation by the Okadaic Acid Class of Tumor Promoters, Okadaic Acid and Dinophysistoxin‐1 (1991) (44)
- Inhibition by quercetin of the promoting effect of teleocidin on skin papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene. (1984) (43)
- Stimulation of arachidonic acid metabolism by different types of tumor promoters. (1985) (43)
- Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression. (2000) (42)
- Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand. (1987) (42)
- The effect of norharman on the metabolism of benzo[alpha]pyrene by rat-liver microsomes in vitro in relation to its enhancement of the mutagenicity of benzo[alpha]pyrene. (1978) (42)
- Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor. (1990) (41)
- Enhanced incorporation of radioactive inorganic phosphate into phospholipids of HeLa cells by tumor promoters. (1983) (41)
- Aggregation of human lymphoblastoid cells by tumor-promoting phorbol esters and dihydroteleocidin B. (1980) (40)
- Flat reversion by okadaic acid of raf and ret-II transformants. (1989) (40)
- Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin. (1990) (39)
- 第3類の新規しゅよう促進剤,ポリアセタート(デブロモアプリシアトキシンおよびアプリシアトキシン)のしゅよう促進効果に関与する生物効果の分化 (1982) (39)
- A blue-green alga from Okinawa contains aplysiatoxins, the third class of tumor promoters. (1985) (39)
- Activation of the EBV‐cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin a, aplysiatoxin and debromoaplysiatoxin (1983) (39)
- Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin. (2017) (38)
- Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins (2016) (38)
- Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters. (1989) (38)
- Challenging the effectiveness of green tea in primary and tertiary cancer prevention (2012) (38)
- Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara. (1992) (37)
- A two-stage mouse skin carcinogenesis study of lyngbyatoxin A (2004) (36)
- Comparative studies of lactate dehydrogenases in lactic acid bacteria. Amino-acid composition of an active-site region and chemical properties of the L-lactate dehydrogenase of Lactobacillus casei, Lactobacillus curvatus, Lactobacillus plantarum, and Lactobacillus acidophilus. (1977) (36)
- Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1. (2002) (35)
- Induction of epstein‐barr virus by a new tumor promoter, teleocidin, compared to induction by TPA (1981) (35)
- Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway. (1989) (35)
- Inhibition of protein phosphatases blocks myogenesis by first altering MyoD binding activity. (1992) (35)
- Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation. (2002) (35)
- Gist of Dr. Katsusaburo Yamagiwa's papers entitled “Experimental study on the pathogenesis of epithelial tumors” (I to VI reports) (2014) (35)
- Teleocidin, lyngbyatoxin A and their hydrogenated derivatives, possible tumor promoters, induce terminal differentiation in HL-60 cells. (1981) (35)
- Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid. (1987) (35)
- The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects. (1993) (34)
- Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin. (1983) (33)
- Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter. (1987) (33)
- Inhibition of protein phosphatase 2A by cantharidin analogues (1996) (33)
- New tumor promoters from marine natural products (1990) (32)
- Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism. (1982) (32)
- Significance of new environmental tumor promoters (1989) (32)
- Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation. (1993) (32)
- Molecular pathogenesis of interstitial pneumonitis with TNF-alpha transgenic mice. (1998) (32)
- Cancer Prevention with Green Tea Polyphenols for the General Population, and for Patients Following Cancer Treatment (2005) (32)
- Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins (2007) (31)
- Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis. (1992) (31)
- Inhibition of methylnitrosourea-induced large bowel cancer development in rats by sarcophytol A, a product from a marine soft coral Sarcophyton glaucum. (1989) (31)
- Stimulation of superoxide anion formation by the non-TPA type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils. (1987) (31)
- Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669. (1988) (29)
- Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. (1992) (29)
- Induction of neoplastic progression in Syrian hamster embryo cells treated with protein phosphatase inhibitors. (1993) (29)
- Characterization of amylases produced by tumors. (1981) (29)
- Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter. (1983) (29)
- Rapid purification of protein phosphatase 2A from mouse brain by microcystin‐affinity chromatography (1991) (28)
- Significance of Heterogeneous Nuclear Ribonucleoprotein B1 as a New Early Detection Marker for Oral Squamous Cell Carcinoma (1999) (28)
- Stimulation of prostaglandin production and choline turnover in HeLa cells by lyngbyatoxin A and dihydroteleocidin B. (1981) (27)
- Hyperphosphorylation of cytokeratins by okadaic acid class tumor promoters in primary human keratinocytes. (1993) (27)
- Okadaic acid and dinophysistoxin-1, non-TPA-type tumor promoters, stimulate prostaglandin E2 production in rat peritoneal macrophages. (1989) (27)
- Activation of Protein Kinase C by Mycobacterial Cord Factor, Trehalose 6‐Monomycolate, Resulting in Tumor Necrosis Factor‐α Release in Mouse Lung Tissues (1995) (26)
- The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers (2018) (26)
- Effects of tumor promoters on the frequency of metallothionein I gene amplification in cells exposed to cadmium. (1983) (26)
- A radioimmunoassay for palytoxin. (1988) (26)
- Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin. (1984) (25)
- Tumor promotion and TNF‐α gene expression by the okadaic acid class tumor promoters (1997) (25)
- Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin. (1989) (24)
- DNA-binding activity of TNF-α inducing protein from Helicobacter pylori (2007) (24)
- Inhibition of pkc and pka by chemopreventive organoselenium compounds. (1995) (24)
- Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. (1997) (24)
- Purification and Properties of the NAD+: Protein ADP‐ribosyltransferase Responsible for the T4‐Phage‐Induced Modification of the œ Subunit of DNA‐Dependent RNA Polymerase of Escherichia coli (1977) (24)
- Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway. (1992) (23)
- Interaction between quercetin and Ca2+-calmodulin complex: possible mechanism for anti-tumor-promoting action of the flavonoid. (1984) (23)
- Involvement of TNF-α changes in human cancer development, prevention and palliative care (2002) (22)
- Distinct inhibitory effects of dihydroteleocidin B and the phorbol ester tumor promoters on the adipocyte differentiation of 3T3-L1 cells. (1983) (22)
- New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. (2001) (22)
- Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages. (1990) (22)
- Purificaton and characterization of a pepsinogen and its pepsin from proventriculus of the Japanese quail. (1980) (22)
- A combination of palytoxin with 1-oleoyl-2-acetyl-glycerol (OAG) or insulin or interleukin-1 synergistically stimulates arachidonic acid metabolism, but combinations of 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters with OAG do not. (1986) (21)
- Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin. (1990) (21)
- Inhibitory Effect of Sarcophytol A on Development of Spontaneous Hepatomas in Mice (1991) (21)
- Production of antibodies to palytoxin: neutralization of several biological properties of palytoxin. (1987) (20)
- Morusin, isolated from root bark of Moms alba L., inhibits tumour promotion of teleocidin (1989) (20)
- New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B. (1990) (20)
- Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin. (1984) (20)
- Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility. (1992) (19)
- Green tea and cancer prevention (2002) (19)
- Sarcophytols A and B inhibit tumor promotion by teleocidin in two-stage carcinogenesis in mouse skin (2004) (19)
- Resiniferonol-related Diterpene Esters from Daphne odora Thunb. and their Ornithine Decarboxylase-inducing Activity in Mouse Skin (1982) (19)
- Echinoclasterol sulfate phenethylammonium salt, a unique steroid sulfate from the marine sponge, Echinoclathria subhispida (1993) (19)
- Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters. (1986) (19)
- Morphological Changes of Human Myeloid Leukemia K562 Cells by a Protein Phosphatase Inhibitor, Tautomycin (1990) (19)
- Differential effects of cryptoporic acids D and E, inhibitors of superoxide anion radical release, on tumor promotion of okadaic acid in mouse skin. (1991) (18)
- Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7-O-(4-azidobenzoyl)okadaate. (1990) (18)
- Carcinogenic potential of tobacco tar-resistant Staphylococcus aureus in buccal cavity (2004) (18)
- Stimulation of histamine release and arachidonic acid metabolism in rat peritoneal mast cells by thapsigargin, a non-TPA-type tumor promoter. (1989) (17)
- Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro. (1988) (17)
- Chemistry and anti-tumor promoting activity of Morus flavonoids. (1988) (17)
- Teleocidin: new naturally occurring tumor promoter. (1982) (17)
- Association of MTG8 (ETO/CDR), a Leukemia‐related Protein, with Serine/Threonine Protein Kinases and Heat Shock Protein HSP90 in Human Hematopoietic Cell Lines (1999) (17)
- Combinations of palytoxin or 12-O-tetradecanoylphorbol-13-acetate and recombinant human insulin growth factor-I or insulin synergistically stimulate prostaglandin production in cultured rat liver cells and squirrel monkey aorta smooth muscle cells. (1986) (17)
- Induction of supermelanin synthesis and morphological changes in interspecific reconstituted cells and its reversal by tumor promoter (1982) (17)
- Similar, potent tumor-promoting activity of all isomers of teleocidins A and B in a two-stage carcinogenesis experiment on the skin of CD-1 mice. (1988) (16)
- Tumor Promoting Activities of New Synthetic Analogues of Teleocidin (1985) (16)
- Palytoxin: an extraordinarily potent stimulator of prostaglandin production and bone resorption in cultured mouse calvariae. (1987) (16)
- Protection of 5α‐dihydrotestosterone against TGF‐β‐induced apoptosis in FaO cells and induction of mitosis in HepG2 cells (1997) (16)
- Mouse 3T3-L1 cell variants unable to respond to mitogenic stimulation of dihydroteleocidin B: genetic evidence for the synergism of tumor promoters with growth factors. (1986) (15)
- Binding studies of [3H]lyngbyatoxin A and [3H]debromoaplysiatoxin to the phorbol ester receptor in a mouse epidermal particulate fraction. (1986) (15)
- Enhancement of Epstein-Barr virus-induced transformation of human lymphocytes by teleocidin. (1981) (15)
- Increased phosphorylation of nuclear phosphoproteins in human lung‐cancer cells resistant to cis‐diamminedichloroplatinum(II) (1992) (15)
- Comparison of 12-O-tetradecanoylphorbol-13-acetate and teleocidin for induction of epidermal hyperplasia, activation of epidermal PKC isozymes and skin tumor promotion in SENCAR and C57BL/6 mice. (1993) (15)
- Increase in the synthesis of a Mr 32,000 protein in BALB/c 3T3 cells treated with tumor-promoting indole alkaloids or polyacetates. (1983) (15)
- An alternative computer model of the 3-dimensional structural of microcystin-LR and nodularin rationalising their interactions with protein phosphatases 1 and 2A (1992) (15)
- Lysis of human immunodeficiency virus infected cells by TPA-type and non-TPA type tumor promoters. (1988) (15)
- Delayed induction of ornithine decarboxylase in mouse skin after irradiation with beta-rays. (1982) (15)
- Pendolmycin, a New Tumor Promoter of the Teleocidin A Class on Skin of CD‐1 Mice (1991) (14)
- Modulation of phorbol ester receptors in mouse skin by application of quercetin. (1986) (14)
- Nakahara memorial lecture. New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. (1983) (14)
- Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring (1996) (14)
- Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein. (2009) (14)
- Tumourigenicity of MTG8, a leukaemia‐related gene, in concert with v‐Ha‐ras gene in BALB/3T3 cells (1998) (14)
- Inhibition of intercellular communication in Chinese hamster V79 cells by teleocidin. (1982) (14)
- The structures of additional teleocidin class tumor promoters. (1986) (14)
- Sarcophytols and Protease Inhibitors Suppress H2O2 Formation and Oxidative DNA Damage (1991) (13)
- Involvement of TNF-alpha changes in human cancer development, prevention and palliative care. (2002) (13)
- Separation of Two Kinds of Polymerase from Alcaligenes faecalis* (1966) (13)
- Analysis of tumor-promoter-induced inflammation in rats: participation of histamine and prostaglandin E2. (1987) (12)
- Significance of MTG8 in leukemogenesis. (1997) (12)
- Involvement of sulfatide in activation of protein kinase C by tumor promoters. (1986) (12)
- A rapid, simple screening method for skin-tumor promoters using mouse peritoneal macrophages in vitro. (1984) (11)
- Significant Marine Natural Products in Cancer Research (1993) (11)
- Induction of histidine decarboxylase activity in mouse skin after application of indole alkaloids, a new class of tumor promoter. (1982) (11)
- Phorbol esters in seed oil of Jatropha curcas L. (saboodam in Thai) and their association with cancer prevention: from the initial investigation to the present topics (2017) (11)
- Diversity in the chemical nature and mechanism of response to tumor promoters. (1989) (11)
- Tumor promoter-dependent mouse leukemia cell line. (1983) (11)
- Sarcophytol A and Its Analogs: Cancer Preventive Activity (1992) (10)
- A new pathway of tumor promotion by the okadaic acid class compounds. (1990) (10)
- [Tumor promotion by inhibitors of protein phosphatase 1 and 2A]. (1998) (10)
- Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells. (1989) (10)
- Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies (2021) (10)
- A new tumor promoter, dihydroteleocidin b, enhances cell growth and the production of murine leukemia virus by fibroblasts (1983) (9)
- Effect of TPA on the mutagenicity of caffeine in the soybean mutation test (1983) (9)
- Presence of a Motif Conserved between Helicobacter pylori TNF-α Inducing Protein (Tipα) and Penicillin-Binding Proteins (2005) (9)
- Naturally-Derived Tumor Promoters and Inhibitors of Carcinogenesis (1996) (9)
- Translational research on TNF-alpha as an endogenous tumor promoter and green tea as cancer preventive in humans. (2005) (9)
- Tautomycin: An inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach (2005) (9)
- DNA-binding activity of TNF-alpha inducing protein from Helicobacter pylori. (2007) (9)
- Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter (2004) (8)
- Cell transformation induced by bovine papillomavirus DNA as an assay for tumor promoters and chemopreventive agents. (1991) (8)
- The role of arginine in interactions of microcystins with protein phosphatases 1 and 2a (1992) (8)
- Seminar on Poly(ADP-Ribose) and ADP-ribosylation of Protine (1975) (8)
- Existence of an optimal dose of dihydroteleocidin B for skin tumor promotion. (1982) (8)
- Innovative strategy of cancer treatment with the combination of green tea catechins and anticancer compounds (2015) (8)
- Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate. (2008) (8)
- Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin. (1993) (8)
- [Chemoprevention of cancer]. (1986) (8)
- Teleocidin-induced modulation of growth and cell interaction in microenvironment-dependent mouse leukemias. (1983) (7)
- Mechanistic Findings of Green Tea as Cancer Preventive for Humans (1999) (7)
- Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages. (1988) (7)
- INTERACTION BETWEEN QUERCETIN AND Ca2+-CALMODULIN COMPLEX (1984) (7)
- Critical biochemical and regulatory events in malignant transformation in vitro. (1983) (7)
- Identification of a mutation within the structural gene for the a subunit of DNA-dependent RNA polymerase of E. coli (1976) (7)
- Calyculins E, F, G, and H, Additional Inhibitors of Protein Phosphatases 1 and 2A, from the Marine Sponge Discodermia calyx. (1991) (7)
- Effect of Tumor Promoters in Relation to the Cell Membrane (1983) (6)
- Structural basis for the Helicobacter pylori carcinogenic TNF〈-inducing protein (2011) (6)
- Effects of various tumor promoters on expression of cartilage phenotypes in rabbit costal chondrocytes in culture. (1987) (6)
- Heterogeneous Nuclear Ribonucleoprotein B 1 as a New Marker of Early Detection for Human Lung Cancers 1 (1999) (5)
- A radioimmunoassay for the teleocidins using 26 (2'-aminoethylthio)-tetrahydroteleocidin A-2 as hapten. (1988) (5)
- Syntheses of isocitric acid derivatives and biological evaluation (2000) (5)
- Significance of the cyanobacterial cyclic peptide toxins, the microcystins and nodularin, in liver cancer (1993) (5)
- Identification of a mutation within the structural gene for the α subunit of DNA-dependent RNA polymerase of E. Coli (2004) (5)
- Marine natural products against tumor development. (1992) (5)
- Tumor promoters may induce the appearance of extrachromosomal circular DNAs in rodent cell lines (1984) (4)
- Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin. (1984) (4)
- Abstract 2665: Green tea catechin, EGCG, enhances antitumor immunity by down-regulation of PD-L1 expression in non-small human lung cancer cell lines (2017) (4)
- U.S.‐Japan Seminar on “Marine Natural Products and Cancer” (1989) (4)
- Designing of chimeric DNA/RNA hammerhead ribozymes to be targeted againstAML1/MTG8 mRNA (2005) (4)
- Mitogenic and comitogenic properties of the indole alkaloid class of tumor promoters (1984) (4)
- Mechanisms of (−)-Epigallocatechin Gallate and Green Tea in Inhibition of Carcinogenesis (1997) (4)
- Tumor Antipromoters: Sarcophytols A and B, (–)–Epigallocatechin Gallate (EGCG), and Morusin (1991) (3)
- Abstract 4723: Innovative cancer treatment of human lung cancer cells PC-9 with a synthetic retinoid Am80 and EGCG via inhibition of HDAC4 and HDAC5 (2016) (3)
- Presence of a motif conserved between Helicobacter pylori TNF-alpha inducing protein (Tipalpha) and penicillin-binding proteins. (2005) (3)
- In vitro catalytic activities of DNA/RNA chimeric hammerhead ribozymes against AML1-MTG8 mRNA, a fused gene transcript in acute myeloid leukemia with t(8;21). (1996) (3)
- [Case of traumatic fistula of the superficial temporal artery, anterior cerebral artery and superior sagittal sinus]. (1967) (3)
- [Inhibitors of protein phosphatases]. (1993) (3)
- Induced secretion of a Mr 46,000 protein by cultured human hepatoma cells treated with tumor promoters. (1985) (3)
- Protection of 5alpha-dihydrotestosterone against TGF-beta-induced apoptosis in FaO cells and induction of mitosis in HepG2 cells. (1997) (3)
- Anti‐tumor Promoting Activity of Canventol and Its Synthetic Analogs through Inhibition of Protein Isoprenylation (1996) (3)
- Binding competition of okadaic acid derivatives to anti-okadaic acid antibody. (1991) (3)
- Purification and properties of the NAD+: protein ADP-ribosyltransferase responsible for the T4-phage-induced modification of the alpha subunit of DNA-dependent RNA polymerase of Escherichia coli. (1977) (3)
- Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene (2004) (2)
- Abstract 2640A: Cell stiffness as a new indicator of diagnosis for human lung cancer cells and their metastasis. (2013) (2)
- Synergistic Effects of ( 2 )-Epigallocatechin Gallate with ( 2 )-Epicatechin, Sulindac, or Tamoxifen on Cancer-preventive Activity in the Human Lung Cancer Cell Line PC-9 1 (1998) (2)
- The seventh Korea–Japan joint symposium on cancer and ageing research: molecular targets in cancer and ageing research (2006) (2)
- 1.2 – Green Tea as a Cancer Preventive (2000) (2)
- Natural Inhibitors of Carcinogenesis (1998) (2)
- Twist form of teleocidin derivatives is active in in vivo tumor promotion by (-)-benzolactam-V8-310. (1998) (2)
- Advances in Brief Synergistic Effects of ( 2 )-Epigallocatechin Gallate with ( 2 )-Epicatechin , Sulindac , or Tamoxifen on Cancer-preventive Activity in the Human Lung Cancer Cell Line PC-91 (1998) (2)
- The unique carcinogenic factor Tipα in cancer microenvironment of H. pylori infection (2007) (2)
- Specific binding of [3H]retinoids to cellular retinoid‐binding proteins (1988) (2)
- U.S.-JAPAN SEMINAR ON“MARINE NATURAL PRODUCTS AND CANCER CHEMOPREVENTION” (1987) (2)
- Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives (2004) (2)
- In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T 7-induced protein kinase ( transcriptional control / phosphothreonine ) (1)
- Increase in frequency of appearance of cadmium-resistant cells induced by various tumor promoters; evidence for the induction of gene amplification. (1983) (1)
- Synergistic anticancer activity of EGCG with cancer preventive agents mediated through GADD153 gene expression in human lung cancer cells (2006) (1)
- The Seoul Symposium of the Journal of Cancer Research and Clinical Oncology Regulation of aging and carcinogenesis (2000) (1)
- Stimulation of arachidonic acid metabolism by a streptococcal preparation (OK-432) in rat peritoneal macrophages. (1992) (1)
- Inhibitory effect of sarcophytol a (SaA) on tumor growth of transplanted human pancreatic cancer cell (MIA paca-2) in nude mice (1993) (1)
- Distinct responses of 3T3-L1 cells to dihydroteleocidin B and the phorbol ester tumor promoters: relation to adipocyte differentiation, DNA synthesis and cell division. (1983) (1)
- [Mechanisms of action of tipa (TNF-alpha inducing protein), a new carcinogenic factor, released from H. pylori]. (2005) (1)
- A comparison of the effects of tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin on gene expression in human skin cell fibroblasts. (1984) (1)
- Japan-Korea Cancer Research Symposium: investigation on the balanced cooperation of cancer cells with the human body (2001) (1)
- [The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion]. (1986) (1)
- New approach to lung cancer prevention mediated through up-regulation of GADD153 gene (2008) (1)
- Relation between the structures of ingenol esters and their ornithine decarboxylase-inducing activities in mouse skin. (1982) (1)
- Heterogeneous Nuclear Ribonucleoprotein B 1 as Early Cancer Biomarker for Occult Cancer of Human Lungs and Bronchial Dysplasia 1 (2001) (1)
- Advances in Brief Hyperphosphorylation of Retinoblastoma Protein and p 53 by Okadaic Acid , a Tumor Promoter (2007) (0)
- deficient Mice α Promotion as Revealed by TNF-) in Tumor α ( TNF-α Essential Role of Tumor Necrosis Factor Updated (1999) (0)
- Abstract 168A: More effective therapy of cancer by the combination of anticancer drugs with green tea catechins. (2013) (0)
- Crystal structure of novel carcinogenic factor of H. pylori (2009) (0)
- EGCG as a Cancer Chemopreventive Agent. (1993) (0)
- Presence of tumor promoters in Jatropha oil of Thailand (1987) (0)
- Mechanism of palytoxin action on the epidermal growth factor receptor (1990) (0)
- Teleocidin, a tumour promoter, stimulates synthesis of primate retroviruses in persistently infected human cells. (1985) (0)
- [Enzymatic study on the biosynthesis of DNA. Required primer of Alcaligenes faecalis DNA polymerase]. (1966) (0)
- 137. Differentiation control in human breast tumor cells by okadaic acid and related phosphatase inhibitors (1992) (0)
- 1P019 Crystal structure of the serine protease from Aeromonas sobria (2005) (0)
- Symposium on “Retinoid Research and Clinical Application” Supported by the Japanese Cancer Association (1990) (0)
- RESISTANCE OF HUMAN BRONCHIAL EPITHELIAL CELLS TO TELEOCIDIN IN A TWO‐STAGE CARCINOGENESIS EXPERIMENT (1987) (0)
- Proceedings: Modification of DNA-dependent RNA polymerase. (1975) (0)
- Differentiation, early response gene expression, and apoptosis induction in human breast tumor cells by Okadaic Acid and related inhibitors of protein phosphatases 1 and 2A. Okadaic acid effects on human breast tumor cells (1992) (0)
- Necrosis Factor Acts as a 1 \ imor Promoter in BALB / 3 T 3 Cell Transformation 1 (2006) (0)
- 在小鼠組織中一種癌症預防的茶多酚[3H]-EGCG之廣泛性分佈 (2009) (0)
- Friendship in research: the Japan–Korea symposia on cancer and ageing (2008) (0)
- TNF-α-inducing protein (Tipα), a unique carcinogenic factor secreted from H. pylori, as a new molecular target for gastric cancer prevention (2007) (0)
- Syntheses of Isocitric Acid Derivatives and Biological Evaluation. (2000) (0)
- Professor Kaichiro Kuroda and Scientific Activity at The Department of Medical Chemistry of Keijo Imperial University in Korea (1930-1941) (2012) (0)
- His Imperial Highness Prince Hitachi (1999) (0)
- Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A. (2023) (0)
- Pd2 SUPERPOSITION OF TELEOCIDINS AND PHORBOL ESTERS BY A NEW COMPUTATIONAL METHOD (1988) (0)
- Abstract 561: Role of nucleolin in activation of NF-κB signaling with Tip≤, a carcinogenic factor ofH. pylori (2012) (0)
- New aspects of cancer prevention with green tea catechin. (2006) (0)
- Structure-Activity Studies of the Nonphorbol Tumor Promoter Palytoxin in Swiss 3 T 3 Cells 1 (2006) (0)
- Diet and Cancer Prevention (1998) (0)
- Abstract 1476: Cell surface nucleolin acts as a specific receptor of Tipα, a carcinogenic factor released fromH. pylori (2010) (0)
- Takeo Wada Cancer Research Symposium in Chiang Mai (2001) (0)
- New Biological Significance of Indole-Containing Compounds as Initiators or Tumor Promoters in Chemical Carcinogenesis (1984) (0)
- Regulation ofcollagenase gene expression byokadaic acid, an inhibitor ofprotein phosphatases (1990) (0)
- [Recent advance of the study of okadaic acid class tumor promoters]. (1993) (0)
- Production of antibodies and development of a radioimmunoassay for palytoxin (1990) (0)
- Progressive Insight into Tumor Promotion with Pro-inflammatory Cytokines (2015) (0)
- Kinase Inhibitor Growth-modulating Agents : Effects of Staurosporine , a Protein Regulation of the Epidermal Growth Factor Receptor by Updated (2006) (0)
- Large c-terminal domain of influenza a virus RNA-dependent polymerase PB2 (2009) (0)
- Proceedings of the 70th general meeting from march 26–28, 1984 (1985) (0)
- Tumor Promoter-dependent Mouse Leukemia Cell Line 1 (2006) (0)
- Abstract 1388: Metastatic potential of B16 melanoma subclones indicated by cell stiffness measured by atomic force microscopy (AFM) (2011) (0)
- The eleventh Korea–Japan–Germany joint symposium on cancer and ageing research (2013) (0)
- Abstract 1143: Induction of epithelial-mesenchymal transition (EMT) in human gastric cancer cell lines induced by Tipα of H. pylori mediated through surface nucleolin (2014) (0)
- Alkyl gallates, derived from structural studies of green tea catechins, as new candidates for cancer preventive agents (2007) (0)
- Structulal Modifications and Regulational Changes of DNA dependent RNA Polymerase from E. coli (1977) (0)
- Abstract 1934: Molecular mechanism of abnormal localization of nucelolin on cell-surface of gastric cancer cells, with regard to Ras signaling pathway (2011) (0)
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What Schools Are Affiliated With Hirota Fujiki?
Hirota Fujiki is affiliated with the following schools: