Hiroyuki Kusuhara

Hiroyuki Kusuhara's AcademicInfluence.com Rankings

Hiroyuki Kusuhara

Computer Science

#8738

World Rank

#9188

Historical Rank

Computational Linguistics

#2001

World Rank

#2023

Historical Rank

Machine Learning

#3657

World Rank

#3703

Historical Rank

Artificial Intelligence

#3968

World Rank

#4026

Historical Rank

computer-science Degrees

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Computer Science

Hiroyuki Kusuhara's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

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Hiroyuki Kusuhara's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics (2003) (506)
Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain* (1999) (483)
Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin (2002) (436)
Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta* (2000) (394)
Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans (2009) (347)
Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir (2007) (286)
Functional Characterization of Rat Brain-specific Organic Anion Transporter (Oatp14) at the Blood-Brain Barrier (2003) (277)
Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone (2010) (259)
Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. (2014) (253)
Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin (2005) (250)
In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney. (2009) (225)
Characterization of uremic toxin transport by organic anion transporters in the kidney. (2004) (218)
Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP) (2014) (214)
Effect of Breast Cancer Resistance Protein (Bcrp/Abcg2) on the Disposition of Phytoestrogens (2007) (207)
Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects (2011) (201)
Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans (2010) (195)
CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS (2005) (193)
Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril (2006) (190)
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. (2003) (187)
Quantitative Evaluation of the Therapeutic Effects of Antibiotics Using Silkworms Infected with Human Pathogenic Microorganisms (2004) (187)
Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney (2012) (185)
Active efflux across the blood-brain barrier: Role of the solute carrier family (2011) (181)
Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier (2001) (179)
Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. (2002) (171)
A Species Difference in the Transport Activities of H2 Receptor Antagonists by Rat and Human Renal Organic Anion and Cation Transporters (2005) (166)
Bile Salt Export Pump (BSEP/ABCB11) Can Transport a Nonbile Acid Substrate, Pravastatin (2005) (163)
Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. (2004) (157)
SLCO1B1 (OATP1B1, an Uptake Transporter) and ABCG2 (BCRP, an Efflux Transporter) Variant Alleles and Pharmacokinetics of Pitavastatin in Healthy Volunteers (2007) (153)
ATP-binding cassette, subfamily G (ABCG family) (2007) (153)
P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier. (1997) (153)
Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans (2008) (150)
Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds (2008) (144)
Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. (2002) (144)
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. (2002) (142)
Species Difference in the Inhibitory Effect of Nonsteroidal Anti-Inflammatory Drugs on the Uptake of Methotrexate by Human Kidney Slices (2007) (142)
Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors. (2004) (141)
Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine (2010) (138)
Multiple Human Isoforms of Drug Transporters Contribute to the Hepatic and Renal Transport of Olmesartan, a Selective Antagonist of the Angiotensin II AT1-Receptor (2007) (138)
Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier (2010) (136)
Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Res (2009) (127)
Investigation of Efflux Transport of Dehydroepiandrosterone Sulfate and Mitoxantrone at the Mouse Blood-Brain Barrier: A Minor Role of Breast Cancer Resistance Protein (2005) (127)
Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP (2012) (125)
Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions (2015) (122)
P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION (2005) (122)
Effects of Intestinal CYP3A4 and P-Glycoprotein on Oral Drug Absorption—Theoretical Approach (1999) (116)
The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs. (1998) (116)
Comparative Inhibitory Effects of Different Compounds on Rat Oatp1 (Slc21a1)- and Oatp2 (Slc21a5)-Mediated Transport (2002) (114)
Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2). (2001) (114)
Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1). (2001) (114)
The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine (2009) (113)
Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug‐Drug Interaction Evaluation: Perspectives From the International Transporter Consortium (2018) (113)
Contribution of Organic Anion Transporter 3 (Slc22a8) to the Elimination of p-Aminohippuric Acid and Benzylpenicillin across the Blood-Brain Barrier (2003) (112)
A role of the Duffy antigen for the maintenance of plasma chemokine concentrations. (2003) (111)
Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans (2010) (111)
Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate (2011) (110)
Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide. (2007) (110)
Efflux transport systems for organic anions and cations at the blood-CSF barrier. (2004) (107)
Effect of excipients on breast cancer resistance protein substrate uptake activity. (2007) (106)
Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine. (1998) (106)
Prediction of Fluoroquinolone‐Induced Elevation in Serum Creatinine Levels: A Case of Drug–Endogenous Substance Interaction Involving the Inhibition of Renal Secretion (2011) (103)
Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein, by Excipients (2007) (103)
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. (1998) (102)
Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine (2008) (99)
Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat (2003) (98)
Characterization of the Uptake of Organic Anion Transporter (OAT) 1 and OAT3 Substrates by Human Kidney Slices (2007) (98)
Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones (2007) (94)
Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments (2011) (94)
Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. (2001) (91)
Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity (2016) (91)
PET Imaging–Based Evaluation of Hepatobiliary Transport in Humans with (15R)-11C-TIC-Me (2012) (91)
The intestinal first-pass metabolism of substrates of CYP3A4 and P-glycoprotein-quantitative analysis based on information from the literature. (2003) (90)
Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil. (2006) (89)
P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier (2008) (88)
In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [11C]Verapamil (2006) (83)
Substrate-Dependent Inhibition of Organic Anion Transporting Polypeptide 1B1: Comparative Analysis with Prototypical Probe Substrates Estradiol-17β-Glucuronide, Estrone-3-Sulfate, and Sulfobromophthalein (2013) (83)
Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain. (1999) (83)
N‐Methylnicotinamide Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving Multidrug and Toxin Extrusions (MATE1 and MATE2‐K) (2012) (83)
Quantitative Analyses of Hepatic OATP‐Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method (2016) (82)
Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes (2011) (81)
Involvement of MRP4 (ABCC4) in the Luminal Efflux of Ceftizoxime and Cefazolin in the Kidney (2007) (80)
A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU (2001) (80)
Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1α/β and DNA Methylation (2006) (80)
Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice. (2004) (79)
Quantitative Evaluation of the Drug-Drug Interactions between Methotrexate and Nonsteroidal Anti-Inflammatory Drugs in the Renal Uptake Process Based on the Contribution of Organic Anion Transporters and Reduced Folate Carrier (2004) (79)
Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney (2005) (74)
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans. (2014) (74)
Endogenous Probes for Drug Transporters: Balancing Vision With Reality (2018) (73)
Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments (2009) (73)
Involvement of Multidrug Resistance Associated Protein 1 (Mrp1) in the Efflux Transport of 17β Estradiol-D-17β-Glucuronide (E217βG) Across the Blood-Brain Barrier (2003) (72)
Gender Difference in the Urinary Excretion of Organic Anions in Rats (2002) (70)
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. (2001) (69)
Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters (2010) (68)
INHIBITION OF OAT3-MEDIATED RENAL UPTAKE AS A MECHANISM FOR DRUG-DRUG INTERACTION BETWEEN FEXOFENADINE AND PROBENECID (2006) (67)
Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers (2018) (64)
Transporter Database, TP-Search: A Web-Accessible Comprehensive Database for Research in Pharmacokinetics of Drugs (2004) (64)
Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases (2007) (63)
Improved liver function and relieved pruritus after 4-phenylbutyrate therapy in a patient with progressive familial intrahepatic cholestasis type 2. (2014) (62)
Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) (2008) (61)
Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. (2002) (61)
Transcriptional Regulation of Human and Mouse Organic Anion Transporter 1 by Hepatocyte Nuclear Factor 1 α/β (2008) (59)
Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. (2013) (59)
Regulation of Tissue-Specific Expression of the Human and Mouse Urate Transporter 1 Gene by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation (2007) (59)
The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. (2004) (58)
Involvement of carrier-mediated transport system in uptake of tetrodotoxin into liver tissue slices of puffer fish Takifugu rubripes. (2007) (56)
Metabolism and pharmacokinetic studies of JPH203, an L-amino acid transporter 1 (LAT1) selective compound. (2012) (53)
Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [11C]Dehydropravastatin in Rats (2013) (53)
Is the Monkey an Appropriate Animal Model to Examine Drug-Drug Interactions Involving Renal Clearance? Effect of Probenecid on the Renal Elimination of H2 Receptor Antagonists (2006) (53)
Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers (2017) (52)
Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one) (2007) (51)
Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs (2020) (50)
Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17beta estradiol-D-17beta-glucuronide (E217betaG) across the blood-brain barrier. (2003) (49)
Involvement of Breast Cancer Resistance Protein (BCRP/ABCG2) in the Biliary Excretion and Intestinal Efflux of Troglitazone Sulfate, the Major Metabolite of Troglitazone with a Cholestatic Effect (2007) (47)
Developmental Changes in P-Glycoprotein Function in the Blood–Brain Barrier of Nonhuman Primates: PET Study with R-11C-Verapamil and 11C-Oseltamivir (2011) (47)
Clarification of the Mechanism of Clopidogrel-Mediated Drug–Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information (2016) (46)
Analysis of DNA Methylation and Histone Modification Profiles of Liver-Specific Transporters (2009) (46)
Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function. (2006) (46)
A microsensing system for the in vivo real-time detection of local drug kinetics (2017) (46)
Investigation of Endogenous Compounds for Assessing the Drug Interactions in the Urinary Excretion Involving Multidrug and Toxin Extrusion Proteins (2013) (46)
Effect of 17β-Estradiol-d-17β-Glucuronide on the Rat Organic Anion Transporting Polypeptide 2-Mediated Transport Differs Depending on Substrates (2002) (45)
Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice (2011) (45)
Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans (2016) (45)
6β-Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects (2014) (44)
Positron Emission Tomography Studies Using (15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin Methyl Ester for the Evaluation of Hepatobiliary Transport (2010) (44)
Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines (2013) (43)
Imaging in the Study of Membrane Transporters (2013) (43)
Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. (2007) (42)
Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. (2006) (42)
High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4). (1999) (42)
Reduced folate derivatives are endogenous substrates for cMOAT in rats. (1998) (41)
Microdose Study of 14C‐Acetaminophen With Accelerator Mass Spectrometry to Examine Pharmacokinetics of Parent Drug and Metabolites in Healthy Subjects (2010) (41)
PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3 (2018) (40)
Construction of Triple-Transfected Cells [Organic Anion-Transporting Polypeptide (OATP) 1B1/Multidrug Resistance-Associated Protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for Analysis of the Sinusoidal Function of MRP3 and MRP4 (2009) (40)
Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system. (2013) (40)
The antipsychotic sultopride is overdosed--a PET study of drug-induced receptor occupancy in comparison with sulpiride. (2006) (40)
Regulation of Tissue-Specific Expression of Renal Organic Anion Transporters by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation (2012) (39)
Expression and Functional Involvement of Organic Anion Transporting Polypeptide Subtype 3 (Slc21a7) in Rat Choroid Plexus (2003) (39)
Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays. (2016) (39)
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins (2017) (39)
Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers. (2019) (39)
Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP. (2017) (39)
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation (2017) (38)
Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [11C]Metformin in Mouse (2015) (38)
Estimation of the Three-Dimensional Pharmacophore of Ligands for Rat Multidrug-Resistance–Associated Protein 2 Using Ligand-Based Drug Design Techniques (2005) (38)
Tensile stress effect on transport properties of (BEDTTTF)2Cu(NCS)2 (1990) (37)
DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines (2010) (37)
Effect of Coadministration of Single and Multiple Doses of Rifampicin on the Pharmacokinetics of Fexofenadine Enantiomers in Healthy Subjects (2013) (37)
GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages (2018) (37)
Evaluation of Breast Cancer Resistance Protein Function in Hepatobiliary and Renal Excretion Using PET with 11C-SC-62807 (2013) (37)
Involvement of Multiple Transporters in the Efflux of 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors across the Blood-Brain Barrier (2004) (36)
The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo. (2013) (36)
Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier? (2004) (36)
Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism (2008) (36)
The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function (2010) (36)
Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 alpha/beta. (2008) (35)
Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2– Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration (2015) (35)
Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches. (2017) (35)
Genome-wide analysis of epigenetic signatures for kidney-specific transporters. (2010) (34)
A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C]Dehydropravastatin in Humans Using Positron Emission Tomography (2018) (33)
Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. (2018) (31)
Phase 0/microdosing approaches: time for mainstream application in drug development? (2020) (31)
Involvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of Troglitazone (2011) (31)
Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1 (2014) (31)
Organic cation transporter/solute carrier family 22a is involved in drug transfer into milk in mice. (2014) (30)
Pharmacokinetics of tetrodotoxin in puffer fish Takifugu rubripes by a single administration technique. (2008) (30)
Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) Transport Edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and Its Sulfate Conjugate (2007) (30)
Successful treatment with 4‐phenylbutyrate in a patient with benign recurrent intrahepatic cholestasis type 2 refractory to biliary drainage and bilirubin absorption (2016) (30)
Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers (2014) (29)
Mechanisms of Pharmacokinetic Enhancement Between Ritonavir and Saquinavir; Micro/Small Dosing Tests Using Midazolam (CYP3A4), Fexofenadine (p‐Glycoprotein), and Pravastatin (OATP1B1) as Probe Drugs (2013) (29)
Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes. (2018) (29)
Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide. (2017) (29)
Characterization of the inhibition of breast cancer resistance protein-mediated efflux of mitoxantrone by pharmaceutical excipients. (2009) (29)
A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions (2017) (28)
Lack of Improvement of Oral Absorption of ME3277 by Prodrug Formation Is Ascribed to the Intestinal Efflux Mediated by Breast Cancer Resistant Protein (BCRP/ABCG2) (2005) (28)
Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface–Resident ABCA1 (2015) (28)
Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse (2010) (27)
Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1. (2011) (27)
Functional Characterization of Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine (2010) (26)
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3. (2004) (26)
Estimation of feasible solution space using Cluster Newton Method: application to pharmacokinetic analysis of irinotecan with physiologically-based pharmacokinetic models (2013) (26)
ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine. (2004) (25)
Evaluation of hepatic uptake clearance of tetrodotoxin in the puffer fish Takifugu rubripes. (2008) (25)
Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects. (2019) (24)
Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment (2019) (24)
Glucuronidation Converting Methyl 1-(3,4-Dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a Potent Apical Sodium-Dependent Bile Acid Transporter Inhibitor, Resulting in a Hypocholesterolemic Action (2007) (24)
Effect of the Fluoroquinolone Antibacterial Agent DX-619 on the Apparent Formation and Renal Clearances of 6β-Hydroxycortisol, an Endogenous Probe for CYP3A4 Inhibition, in Healthy Subjects (2013) (24)
Drug-Drug Interactions Involving the Membrane Transport Process (2001) (24)
Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development. (2013) (23)
Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components. (2014) (23)
Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier. (2017) (23)
Calreticulin facilitates the cell surface expression of ABCG5/G8. (2006) (23)
Hepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4 (2011) (23)
DNA Methylation and Histone Modification Profiles of Mouse Organic Anion Transporting Polypeptides (2013) (22)
Modest Effect of Impaired P-glycoprotein on the Plasma Concentrations of Fexofenadine, Quinidine, and Loperamide following Oral Administration in Collies (2008) (21)
FUNCTIONAL INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 2 (SLC22A7) IN THE HEPATIC UPTAKE OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG KETOPROFEN (2005) (21)
Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates. (2014) (21)
SLCO1A2-MDCKII: a Promising in vitro System to Understand the Role of OATP1A2 in Blood Brain Barrier Drug Penetration (2015) (20)
Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs (2016) (20)
How far should we go? Perspective of drug-drug interaction studies in drug development. (2014) (20)
Pim-1L Protects Cell Surface–Resident ABCA1 From Lysosomal Degradation in Hepatocytes and Thereby Regulates Plasma High-Density Lipoprotein Level (2016) (20)
Rapid Elimination of Cefaclor from the Cerebrospinal Fluid Is Mediated by a Benzylpenicillin-Sensitive Mechanism Distinct from Organic Anion Transporter 3 (2005) (20)
Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates. (2002) (19)
Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus. (2004) (18)
Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo (2018) (18)
Impaired Hepatic Uptake by Organic Anion-Transporting Polypeptides Is Associated with Hyperbilirubinemia and Hypercholanemia in Atp11c Mutant Mice (2015) (18)
Identification of the Transporters Involved in the Hepatobiliary Transport and Intestinal Efflux of Methyl 1-(3,4-Dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) Glucuronide, a Pharmacologically Active Metabolite of S-8921 (2008) (18)
Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties. (2013) (17)
Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist. (2017) (17)
Efflux mechanism of taurocholate across the rat intestinal basolateral membrane. (2006) (17)
Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model. (2017) (17)
Effects of Cremophor EL on the absorption of orally administered saquinavir and fexofenadine in healthy subjects. (2015) (17)
Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice (2015) (17)
Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction (2019) (17)
Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals (2012) (17)
Quantitative Investigation of the Brain-to-Cerebrospinal Fluid Unbound Drug Concentration Ratio under Steady-State Conditions in Rats Using a Pharmacokinetic Model and Scaling Factors for Active Efflux Transporters (2014) (16)
Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells. (2017) (16)
The synthesis of [18F]pitavastatin as a tracer for hOATP using the Suzuki coupling. (2015) (16)
Superconducting Phases with Single Tl-O Layer Structure Preparation: (Tl, Pb)Can-1Ba2CunO2n+3 (n=2, 3, 4, 5, 6) (1989) (16)
Characterization of the transport of a cationic octapeptide, octreotide, in rat bile canalicular membrane: possible involvement of P-glycoprotein. (1998) (15)
Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203. (2013) (15)
Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories (2019) (15)
Studies on the intestinal absorption characteristics of sulfasalazine, a breast cancer resistance protein (BCRP) substrate. (2013) (14)
Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein‐Mediated Drug‐Drug Interactions in Healthy Volunteers (2020) (14)
Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier (2018) (14)
Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion. (2019) (13)
Evaluation of the potency of telaprevir and its metabolites as inhibitors of renal organic cation transporters, a potential mechanism for the elevation of serum creatinine. (2014) (13)
Elucidation of N1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters (2019) (13)
Alteration in the Plasma Concentrations of Endogenous Organic Anion–Transporting Polypeptide 1B Biomarkers in Patients with Non–Small Cell Lung Cancer Treated with Paclitaxel (2020) (13)
A clinical pharmacokinetic microdosing study of docetaxel with Japanese patients with cancer (2015) (13)
Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models. (2017) (12)
Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice (2018) (12)
Crystal Structures of BaBiO3-x at High Temperatures (1989) (12)
Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components (2019) (11)
Detection of Pulmonary Teleangiectasia Using Dynamic Pulmonary Perfusion Imaging in Patients with Liver Cirrhosis (1989) (11)
Expression and Functional Characterization of Rat Organic Anion Transporter 3 ( rOat 3 ) in the Choroid Plexus (2002) (11)
Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development. (2020) (11)
Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator. (2006) (11)
Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats. (2016) (11)
Brain Efflux Index Method (2003) (10)
Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis (2018) (10)
Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes. (2021) (9)
Active efflux across the blood-brain barrier: Role of the solute carrier family (2005) (9)
Reversibility of hepatopulmonary syndrome evidenced by serial pulmonary perfusion scan (1993) (9)
Quantitative investigation of hepatobiliary transport of [11C]telmisartan in humans by PET imaging. (2019) (9)
Generation of human-induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies. (2021) (9)
Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers (2019) (8)
Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages (2017) (8)
Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method (2010) (8)
Forskolin modifies retinal vascular development in Mrp4-knockout mice. (2012) (8)
Brain efflux index method. Characterization of efflux transport across the blood-brain barrier. (2003) (8)
Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects. (2017) (7)
Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban. (2017) (7)
Impact of P-Glycoprotein–Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates (2020) (7)
Radiosynthesis of novel pitavastatin derivative ([18 F]PTV-F1) as a tracer for hepatic OATP using a one-pot synthetic procedure. (2016) (7)
Alteration in the plasma concentrations of endogenous OATP1B-biomarkers in non-small cell lung cancer patients treated with paclitaxel. (2020) (7)
Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802 (2016) (6)
In Vivo Characterization of Interactions on Transporters (2013) (6)
Efflux transport systems at the blood–brain barrier and blood CSF barrier (2005) (6)
Drug Transport in the Kidney (2014) (6)
Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents (2016) (6)
Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics (2019) (6)
Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients. (2019) (6)
Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier (2020) (6)
Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum (2020) (6)
Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney. (2019) (6)
Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor (2020) (5)
Determination of the Kinetic Parameters for 123I Uptake by the Thyroid, Thyroid Weights, and Thyroid Volumes in Present-day Healthy Japanese Volunteers. (2020) (5)
Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data. (2017) (5)
Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method (2018) (5)
Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure (2021) (5)
Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis (2019) (5)
Decomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural Products. (2021) (5)
Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments. (2016) (4)
Evaluation of hepatic uptake of OATP1B substrates by short term-cultured plated human hepatocytes: Comparison with isolated suspended hepatocytes. (2020) (4)
Effects of 4‐phenylbutyrate therapy in a preterm infant with cholestasis and liver fibrosis (2016) (4)
Assessment of Adenosine Triphosphatase Phospholipid Transporting 8B1 (ATP8B1) Function in Patients With Cholestasis With ATP8B1 Deficiency by Using Peripheral Blood Monocyte‐Derived Macrophages (2020) (4)
Analysis of hiPSCs differentiation toward hepatocyte-like cells upon extended exposition to oncostatin. (2020) (4)
Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regeneration (2021) (4)
Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs (2020) (4)
Difference in Mechanism-Based Inhibition of Cytochrome P450 3A4 and 3A5 by a Series of Fluoroquinolone Antibacterial Agents (2017) (4)
Interesting Properties of Profile Data Analysis in the Understanding and Utilization of the Effects of Drugs. (2020) (3)
Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice. (2015) (3)
Evaluation of [11C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey models of viral infection (2014) (3)
Elevated paraneoplastic hypercholesterolemia in a case of hepatoid adenocarcinoma of the stomach with liver metastasis (2013) (3)
Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation (2020) (3)
Quantitative prediction of pharmacokinetic properties of drugs in humans: recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood–brain barrier (2021) (3)
Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs (2022) (3)
Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions (2022) (3)
Relative activity factor (RAF)-based scaling of uptake clearance of OATP1B substrates from transfected cell systems to human hepatocytes and to in vivo (2019) (2)
Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging. (2019) (2)
Transport Characteristics of 6-Mercaptopurine in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. (2021) (2)
ACTIVE EFFLUX OF RO 64-0802, THE ACTIVE FORM OF OSELTAMIVIR, ACROSS THE BLOOD-BRAIN BARRIER (2008) (2)
Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors (2020) (2)
Development of a Novel Platform of Proteome Profiling Based on an Easy-to-Handle and Informative 2D-DIGE System. (2019) (2)
Lack of Contribution of P-Glycoprotein (P-gp) to Transport via the Mouse Blood-Cerebrospinal Fluid Barrier (2005) (2)
Kinetic profile of overall elimination of 5-methyltetrahydropteroylglutamate in rats. (1999) (2)
Detection of pulmonary telangiectasia using dynamic pulmonary perfusion imaging in patients with liver cirrhosis. (1989) (2)
Kinetic profile of overall elimination of 5-methyltetrahydropteroylglutamate in rats. (1999) (2)
Proposal of a Parameter for OATP1B1 Inhibition Screening at the early Drug Discovery Stage. (2019) (2)
Coordination of Uptake and Efflux Transporters in Drug Disposition (2007) (2)
[The role of P-glycoprotein in the liver]. (1997) (2)
A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers. (2021) (2)
Identification of the transporters involved in the hepatobiliary transport and intestinal efflux of S-8921 glucuronide , a pharmacologically active metabolite of S-8921 (2008) (2)
Usefulness of Human Jejunal Spheroid–Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans (2022) (1)
Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity. (2022) (1)
Determination of kinetic parameters for 123-I thyroid uptake in healthy Japanese (2017) (1)
Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers (2018) (1)
323 A clinical pharmacokinetic microdosing study of docetaxel with Japanese cancer patients (2015) (1)
Organic Anion and Cation Drug Transporters (2011) (1)
Functional investigation of solute carrier family 35, member F2 (SLC35F2) in three cellular models of the primate blood–brain barrier (2020) (1)
Frequency of null genotypes of glutathione S‐transferase M1 and T1 in Japanese patients with drug‐induced liver injury (2022) (1)
Cylindrical position‐sensitive x‐ray detector for fast powder diffractometry (1989) (1)
Corrigendum to "Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data" [Drug Metab Pharmacokinet 32 (2017) 135-144]. (2017) (1)
Functional characterization of mouse Oatp 1 a 4 in the uptake and efflux of drugs across the blood – brain barrier (2009) (1)
NRBdMF: A recommendation algorithm for predicting drug effects considering directionality (2022) (1)
A rapid and simple electrochemical detection of the free drug concentration in human serum using boron-doped diamond electrodes. (2022) (1)
Investigation of a Data Split Strategy Involving the Time Axis in Adverse Event Prediction Using Machine Learning (2022) (1)
Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers (2019) (1)
Crystal Growth and Properties of (BEDT-TTF)2Cu(NCS)2 (1990) (1)
Practical synthesis of [18F]pitavastatin and evaluation of hepatobiliary transport activity in rats by positron emission tomography. (2020) (1)
UPTAKE TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS. (2005) (1)
Investigation of chemical structure recognition by encoder–decoder models in learning progress (2022) (1)
Functional characterization of MRP4 (2004) (0)
Clinical Pharmacokinetic Studies of Drug Transporters (2020) (0)
A case of acute excerbation of latent autoimmune hepatitis with severe jaundice after treatment of recombinant human alpha-interferon. (1993) (0)
Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist. (2017) (0)
A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions (2017) (0)
Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders (2021) (0)
Integration of imaging techniques to study distribution of drugs in tissues (2018) (0)
29 S 5 B-3 HYPOCHOLESTEROLEMIC ACTION AND HEPATOBILIARY TRANSPORT OF METHYL-1-( 3 , 4-DIMETHOXYPHENYL )-3-( 3-ETHYLVALERYL )-4-HYDROXY-6 , 7 , 8-TRIMETHOXY-2-NAPHTHOATE ( S-8921 ) GLUCURONIDE (2006) (0)
Expression and functional characterization of breast cancer resistance protein (ABCG2) in mouse intestine (2005) (0)
Role of breast cancer resistance protein in the blood-brain and -testis barriers (2006) (0)
Prediction of Chemical Reaction Type with Hierarchical Graph Neural Networks (2022) (0)
Acknowledgment on Developing Drugs (2021) (0)
Investigation of Endogenous Compounds for Assessing the Drug Interactions in the Urinary Excretion Involving Multidrug and Toxin Extrusion Proteins (2013) (0)
Uniaxial Stress Effects on Organic Superconductor κ-(BEDT-TTF)2Cu(NCS)2 (1990) (0)
Effect of Tensile Stress on the Superconducting Transition Temperature in (BEDT-TTF)2Cu(NCS)2 (1990) (0)
[Understanding of Multiple Effects of Low Molecular Weight Compounds with Factor Analysis]. (2023) (0)
Identification of transporters involved in the hepatobiliary transport of PET probe, 15R- [11C]TIC, change in its plasma and hepatic concentration by drug interaction in humans and its prediction from in vitro experiments (2009) (0)
A microsensing system for the in vivo real-time detection of local drug kinetics (2017) (0)
Prospect of in vitro Bile Fluids Collection in Improving Cell-Based Assay of Liver Function (2021) (0)
Transport systems for organic anions in the blood-brain barrier (2005) (0)
[Quantitative assessment of the risk of OATP1B1/1B3-mediated drug-drug interactions]. (2019) (0)
Quantitative investigation of OATP1B-mediated drug-drug interactions using endogenous substrates (2019) (0)
Preface (2020) (0)
IN VITRO STUDY OF THE MECHANISMS OF TERBINAFINE ASSOCIATED HEPATIC INJURY (2010) (0)
[Development of in vivo drug sensing system with needle-type diamond microelectrode]. (2019) (0)
Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components (2019) (0)
Human organic anion transporters 1 (hOAT1/ ) and 3 (hOAT3/ ) transport edaravone (MCI-186; and its sulfate conjugate. (2007) (0)
Effect of pharmaceutical excipients on the function of intestinal xenobiotics efflux transporter, the breast cancer resistance protein (2005) (0)
VECTORIAL TRANSPORT OF ORGANIC ANIONS ACROSS LLC-PK1 CELL MONOLAYERS (2004) (0)
Development of in vitro models for assessing the pharmacokinetic properties of new chemical entities in humans (2022) (0)
The role of breast cancer resistance protein, Bcrp in the transport of estrone-3-sulfate and dehydroepiandrosterone sulfate across the blood-brain barrier (2003) (0)
The drug-drug interactions of clopiodgrel for OATP1B1 and CYP2C8: In vitro prediction and a clinical cassette small-dose study (2017) (0)
P238 - Functional investigation of solute carrier family 35 member F2 (SLC35F2) as a drug transporter in the blood-brain barrier (2020) (0)
Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies (2022) (0)
Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers (2019) (0)
A microsensing system for the in vivo real-time monitoring of local drug kinetics (2018) (0)
Molecular structure and drug transport of the blood-brain barrier (2012) (0)
Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis (2018) (0)
Construction of a physiologically-based pharmacokinetic model of coproporphyrin I, a putative endogenous probe for hepatic OATP1Bs and MRP2 (2018) (0)
Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood–Brain Barrier of Mice (2022) (0)
Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [11C]Metformin in Mouse (2015) (0)
Retinal Vascular Development in Mrp 4-Knockout Mice (2012) (0)
Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802 (2016) (0)
Effect of Food on the Pharmacokinetics and Efficacy of 4-Phenylbutyrate in Progressive Familial Intrahepatic Cholestasis (2019) (0)
JPET #206425 1 Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion using Newly Developed Positron Emission Tomography (PET) Tracer, [C]Dehydropravastatin, in Rats (2013) (0)
P59 - Development of a novel profile data analysis method to aid deep understanding of pharmacodynamics by decomposing the complex effects of a drug (2020) (0)
The influence of serial 50 μL microsampling on rats administered azathioprine, the immunosuppressive drug (2023) (0)
Title Regulation of Tissue-specific Expression of Renal Organic Anion Transporters by Hepatocyte Nuclear Factor 1 α / β and DNA Methylation (2011) (0)
Development of endogenous biomarkers to assess drug-transporter-mediated drug-drug interactions in drug development (2021) (0)
Chapter 22:Impact of Drug Transporters in the Pharmacological and Adverse Reactions of Drugs (2011) (0)
[FOREWORD]Application of microfluidics to DDS research (2019) (0)
Difficulty in learning chirality for Transformer fed with SMILES (2023) (0)
IMPORTANCE OF EVALUATING CONTRIBUTIONS OF TRANSPORTERS IN DRUG DEVELOPMENT: AN APPROACH USING SELECTIVE INHIBITORS (2001) (0)
Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers (2014) (0)
EFFECT OF 17 (cid:1) -ESTRADIOL- D -17 (cid:1) -GLUCURONIDE ON THE RAT ORGANIC ANION TRANSPORTING POLYPEPTIDE 2-MEDIATED TRANSPORT DIFFERS DEPENDING ON SUBSTRATES (2002) (0)
Phase 0/microdosing approaches: time for mainstream application in drug development? (2020) (0)
Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method (2023) (0)
Relationship between lipid peroxidation and liver fibrosis in patients with alcoholic liver disease (1995) (0)
MULTIPLE ORGANIC ANION TRANSPORTERS INVOLVED IN BLOOD-BRAIN BARRIER TRANSPORT (2009) (0)
QUANTITATIVE INVESTIGATION OF THE SYNERGISTIC ROLE OF P-GLYCOPROTEIN (P-GP/ABCB1) AND BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) IN LIMITING THE BRAIN AND TESTIS PENETRATION OF ERLOTINIB AND MITOXANTRONE (2009) (0)
Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo (2018) (0)
restricts the of across the (2007) (0)
Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers (2017) (0)
P74 - Evaluation of endogenous biomarkers of OATP1B activity in patients with non-small cell lung cancer who receive paclitaxel (2020) (0)
Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes. (2020) (0)
DMD055475 685..694 (2014) (0)
DNAMethylation and Histone Modification Profiles of Mouse Organic Anion Transporting Polypeptides s (2012) (0)
Effect of the Fluoroquinolone Antibacterial Agent DX-619 on the Apparent Formation and Renal Clearances of 6β-Hydroxycortisol, an Endogenous Probe for CYP3A4 Inhibition, in Healthy Subjects (2012) (0)
Polymorphisms of Two Anion Transporters (OATP-C and MRP2) Genes - Consequences for Pravastatin Pharmacokinetics (2003) (0)
Development of in vivo drug sensing system with needle-type diamond microelectrode. (2019) (0)
Clinical assessment of renal drug-drug interactions using endogenous substrates (2018) (0)
MOUSE RST FACILITATES TRANSCELLULAR TRANSPORT OF ORGANIC ANIONS BY A COORDINATION OF BASOLATERAL ORGANIC ANIO N TRANSPORTERS (OAT3 ) (2004) (0)
Current status and prospects of phenotype analysis of drug transporters using endogenous metabolites (2021) (0)
Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice (2015) (0)
TELMISARTAN IN RATS (2009) (0)
Microsoft Word-55038909-file00 (2009) (0)
Elucidation of N 1 -methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters s (2019) (0)
INVESTIGATION OF FGF23-MEDIATED REGULATION OF RENAL TRANSPORTERS (2009) (0)
Lipid accumulation enhances cell-surface atp-binding cassette transporter a1 (abca1) degradation in ub-lysosome degradation pathway (2014) (0)
Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines (2013) (0)
Integrative analysis of transporter-mediated drug-drug interactions (2014) (0)
Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain. (2023) (0)
Orthogonal linear separation analysis: an approach to decompose the complex effects of a perturbagen (2018) (0)
[Adverse effects of drugs induced by transporter-mediated tissue distribution and elimination]. (2008) (0)
INVOLVEMENT OF MOUSE OATP1A4 IN THE UPTAKE OF ORGANIC ANIONS ACROSS THE BLOOD-BRAIN BARRIER (2006) (0)
Investigation of the usefulness of liver-specific deconvolution method toward legacy data utilization (2023) (0)
Heteroduplex oligonucleotide as a platform technology to modulate blood-brain barrier function in vivo (2017) (0)
Pharmacophore Estimation and 3D-QSAR of Ligands for Organic Anion Transporting Polypeptide 1B1 (OATP1B1) (2008) (0)
Impact of Direction of Transport on the Evaluation of Substrate Recognition of Mouse Multidrug and Toxin Extrusion Protein 1 (2023) (0)
Characterization of efflux transporters in the net uptake of dehydroepiandrosterone sulfate and mitoxantrone via the blood-brain barrier in the mouse (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜講演要旨集) (2003) (0)
Extraction of diverse gene groups with individual relationship from gene co-expression networks (2021) (0)

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