Hiroyuki Mano

Q: What Schools Are Affiliated With Hiroyuki Mano

Hiroyuki Mano is affiliated with the following schools: University of Oxford, University of Tokyo, Jichi Medical University, Institute of Science Tokyo, Mie University, Dokkyo University, Osaka University, Kyoto University, Erasmus University Rotterdam

Hiroyuki Mano's AcademicInfluence.com Rankings

Hiroyuki Mano

Computer Science

#8506

World Rank

#8942

Historical Rank

Computational Linguistics

#1904

World Rank

#1924

Historical Rank

Machine Learning

#3497

World Rank

#3540

Historical Rank

Artificial Intelligence

#3801

World Rank

#3856

Historical Rank

computer-science Degrees

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Computer Science

Hiroyuki Mano's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

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Hiroyuki Mano's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer (2007) (4776)
RET, ROS1 and ALK fusions in lung cancer (2012) (1203)
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. (2010) (1142)
Oncogenic mutations of ALK kinase in neuroblastoma (2008) (861)
KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer (2009) (668)
A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner. (1994) (662)
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer (2012) (543)
Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts (2008) (490)
A mouse model for EML4-ALK-positive lung cancer (2008) (488)
EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers (2008) (461)
EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset (2009) (445)
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. (2008) (424)
Generation of the AML1‐EVI‐1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. (1994) (340)
In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents. (2001) (294)
Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (2006) (281)
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies (2020) (281)
KLC1-ALK: A Novel Fusion in Lung Cancer Identified Using a Formalin-Fixed Paraffin-Embedded Tissue Only (2012) (251)
Array-based genomic resequencing of human leukemia (2010) (251)
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. (2011) (250)
Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk (2000) (227)
A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome (1987) (226)
Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF (2003) (216)
Non‐solid oncogenes in solid tumors: EML4–ALK fusion genes in lung cancer (2008) (215)
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults (2016) (177)
miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. (2011) (169)
c‐fps/fes protein‐tyrosine kinase is implicated in a signaling pathway triggered by granulocyte‐macrophage colony‐stimulating factor and interleukin‐3. (1993) (167)
ALKoma: a cancer subtype with a shared target. (2012) (166)
Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction. (2001) (162)
A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer (2017) (160)
EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (2010) (160)
Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines. (1995) (157)
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases (2018) (154)
Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit. (1993) (141)
Genome‐wide histone methylation profile for heart failure (2009) (141)
A novel protein-tyrosine kinase, tec, is preferentially expressed in liver. (1990) (139)
Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia. (1993) (139)
Tec family of protein-tyrosine kinases: an overview of their structure and function. (1999) (136)
Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas (2004) (130)
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation (2018) (124)
Genomic characterization of primary central nervous system lymphoma (2016) (123)
A Prospective PCR-Based Screening for the EML4-ALK Oncogene in Non–Small Cell Lung Cancer (2012) (122)
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. (2022) (120)
Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation. (2006) (115)
Transforming mutations of RAC guanosine triphosphatases in human cancers (2013) (113)
Identification of anaplastic lymphoma kinase fusions in renal cancer (2012) (111)
Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding (1994) (109)
Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. (2000) (106)
Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation. (1999) (105)
Mouse microRNA profiles determined with a new and sensitive cloning method (2006) (105)
Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes. (2001) (102)
Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability (2006) (102)
Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins (1995) (101)
Bruton's Tyrosine Kinase Is Required For Lipopolysaccharide-induced Tumor Necrosis Factor α Production (2003) (100)
Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells (2012) (99)
Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13 (1998) (98)
Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1–ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification (2011) (96)
Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. (1995) (96)
Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells (2005) (95)
Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma (2011) (94)
Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice. (1995) (92)
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia (2017) (90)
Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells. (1993) (88)
Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells (2001) (87)
Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy (2011) (83)
A genomic analysis of adult T-cell leukemia (2007) (83)
An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells. (2020) (83)
Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos. (2009) (83)
Recurrent CDC25C mutations drive malignant transformation in FPD/AML (2014) (81)
Dicer plays essential roles for retinal development by regulation of survival and differentiation. (2011) (77)
Small-RNA asymmetry is directly driven by mammalian Argonautes (2015) (76)
Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway. (1995) (76)
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis (2018) (75)
An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension (2006) (72)
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects (2015) (71)
Chromosome copy number analysis in screening for prognosis‐related genomic regions in colorectal carcinoma (2008) (71)
DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome (2003) (70)
Integrated molecular profiling of juvenile myelomonocytic leukemia. (2018) (67)
miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A (2015) (66)
Relationship between an activated N-ras oncogene and chromosomal abnormality during leukemic progression from myelodysplastic syndrome. (1988) (66)
Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion. (1995) (64)
Corrigendum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects (2015) (64)
Fluvastatin Induces Apoptosis in Rat Neonatal Cardiac Myocytes: A Possible Mechanism of Statin-Attenuated Cardiac Hypertrophy (2002) (62)
Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells (2018) (60)
Identification of mechanically induced genes in human monocytic cells by DNA microarrays (2002) (60)
Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome (2008) (59)
A Specific Role of Phosphatidylinositol 3–Kinase γ: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells (2001) (59)
Signal Transducers and Activators of Transcription 3 Augments the Transcriptional Activity of CCAAT/Enhancer-binding Protein α in Granulocyte Colony-stimulating Factor Signaling Pathway* (2005) (58)
High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. (2007) (58)
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations (2019) (57)
Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1 alpha, and granulocyte colony-stimulating factor. (1989) (56)
Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines (2007) (56)
Reprogramming of human postmitotic neutrophils into macrophages by growth factors. (2004) (56)
Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation (2014) (55)
Gene expression profiling of human atrial myocardium with atrial fibrillation by DNA microarray analysis. (2005) (53)
Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. (1999) (53)
Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. (2008) (52)
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines (2006) (52)
Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders (2003) (52)
Expression and Activation of the Nonreceptor Tyrosine Kinase Tec in Human B Cells (1998) (51)
DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel. (2017) (50)
Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4–ALK-rearranged non–small–cell lung cancer harbored coexisting EGFR mutation (2013) (49)
Antiapoptotic Effect of Endothelin-1 in Rat Cardiomyocytes In Vitro (2003) (47)
MicroRNA‐31 is a positive modulator of endothelial–mesenchymal transition and associated secretory phenotype induced by TGF‐β (2016) (46)
Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: an application for rapid purification of the PIP3 binding proteins. (1998) (45)
The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells. (1994) (44)
Molecular cloning and analysis of the human Tec protein-tyrosine kinase. (1994) (43)
Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase (1998) (42)
High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays (2008) (42)
High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2 (2018) (42)
Sak Serine-Threonine Kinase Acts as an Effector of Tec Tyrosine Kinase* (2001) (40)
The Tec family protein-tyrosine kinases: a subset of kinases for a subset of signalings. (1999) (40)
Analysis of Gene Expression Profiles in an Imatinib‐Resistant Cell Line, KCL22/SR (2003) (39)
Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers (2018) (39)
The Tyr-Kinase Inhibitor AG879, that Blocks the ETK-PAK1 Interaction, Suppresses the RAS-induced PAK1 Activation and Malignant Transformation (2004) (39)
Oncogenic MAP2K1 mutations in human epithelial tumors. (2012) (39)
Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency (2017) (37)
Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets (1998) (36)
Cancer‐associated missense mutations of caspase‐8 activate nuclear factor‐κB signaling (2013) (36)
Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens (2019) (36)
DNA microarray analysis of in vivo progression mechanism of heart failure. (2003) (35)
A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors (2021) (34)
Huge lipomatous pseudohypertrophy of the pancreas. (1979) (34)
Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells. (1997) (34)
Profiling of microRNA expression by mRAP (2007) (34)
Tec protein-tyrosine kinase directly associates with Lyn protein-tyrosine kinase through its N-terminal unique domain. (1994) (33)
Genome-Wide Screening for Target Regions of Histone Deacetylases in Cardiomyocytes (2005) (33)
Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening (2010) (33)
Ex Vivo Expansion of Human CD8+ T Cells Using Autologous CD4+ T Cell Help (2012) (32)
Mediation by the Protein-tyrosine Kinase Tec of Signaling between the B Cell Antigen Receptor and Dok-1* (2000) (32)
Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c- fos Transcription (1998) (31)
Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor. (1996) (30)
A novel strategy for the tumor angiogenesis-targeted gene therapy: Generation of angiostatin from endogenous plasminogen by protease gene transfer (2000) (30)
Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels (2021) (29)
ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity. (2012) (29)
Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing (2019) (29)
Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial) (2020) (28)
Treatment of lung cancer with an ALK inhibitor after EML4-ALK fusion gene detection using endobronchial ultrasound-guided transbronchial needle aspiration. (2010) (27)
Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells. (1998) (27)
β2-Microglobulin Identified as an Apoptosis-Inducing Factor and Its Characterization (1999) (26)
Identification of a constitutively active mutant of JAK3 by retroviral expression screening. (2007) (26)
Tec protein-tyrosine kinase is involved in the thrombopoietin/c-Mpl signaling pathway. (1997) (26)
Identification of novel CD74-NRG2α fusion from comprehensive profiling of lung adenocarcinoma in Japanese never or light smokers. (2020) (25)
Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma (2003) (25)
Activation of insulin‐like growth factor‐1 receptor confers acquired resistance to osimertinib in non‐small cell lung cancer with EGFR T790M mutation (2019) (24)
Ethical concerns on sharing genomic data including patients’ family members (2018) (23)
Nucleotide sequence and embryonic expression of quail and duck Sox9 genes. (2006) (23)
High-throughput functional evaluation of BRCA2 variants of unknown significance (2020) (23)
DNA microarray analysis of hematopoietic stem cell-like fractions from individuals with the M2 subtype of acute myeloid leukemia (2003) (23)
PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes. (2022) (23)
Inactivating mutations and hypermethylation of the NKX2‐1/TTF‐1 gene in non‐terminal respiratory unit‐type lung adenocarcinomas (2017) (23)
Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities (2021) (23)
Identification of a soluble GM-CSF binding protein in the supernatant of a human choriocarcinoma cell line. (1992) (23)
Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-κB-activating potential (2015) (22)
Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening (2007) (22)
Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription. (1998) (22)
Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer. (2016) (21)
DNA microarray analysis of natural killer cell-type lymphoproliferative disease of granular lymphocytes with purified CD3−CD56+ fractions (2004) (21)
Genistein-Induced Changes in Gene Expression in Panc 1 Cells at Physiological Concentrations of Genistein (2004) (21)
Cloning and characterization of mouse tec promoter. (1996) (21)
Cardiac function-related gene expression profiles in human atrial myocytes. (2004) (20)
Mutual Regulation of Protein-tyrosine Phosphatase 20 and Protein-tyrosine Kinase Tec Activities by Tyrosine Phosphorylation and Dephosphorylation* (2004) (20)
The EML4-ALK oncogene: targeting an essential growth driver in human cancer (2015) (20)
DNA microarray analysis of T cell‐type lymphoproliferative disease of granular lymphocytes (2002) (20)
Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter. (2005) (20)
Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes (2019) (19)
Deletion of Src Homology 3 Domain Results in Constitutive Activation of Tec Protein‐Tyrosine Kinase (1996) (19)
MicroRNA expression profiles of human leukemias (2008) (19)
Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries. (2009) (18)
EML4-ALK fusion in lung. (2010) (18)
Schedule-dependent interactions between pemetrexed and cisplatin in human carcinoma cell lines in vitro. (2006) (18)
Retroviral expression screening of oncogenes in pancreatic ductal carcinoma. (2005) (17)
DNA microarray analysis of dysplastic morphology associated with acute myeloid leukemia. (2004) (17)
The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro. (2009) (17)
A G-CSF receptor-gyrase B fusion gene: A new type of molecular switch for expansion of genetically modified hematopoietic cells. (1999) (17)
Transforming activity of purinergic receptor P2Y, G-protein coupled, 2 revealed by retroviral expression screening. (2007) (17)
Abstract A227: Antitumor activities of ASP3026 against EML4-ALK-dependent tumor models. (2011) (17)
Endogenously generated nitric oxide by nitric-oxide synthase gene transfer inhibits cellular proliferation. (2000) (17)
Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma (2017) (16)
Detection of the PML/RAR alpha fusion gene in acute promyelocytic leukemia with a complex translocation involving chromosomes 15, 17, and 18. (1993) (16)
Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations. (2021) (16)
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer (2021) (16)
miR-135 b mediates NPM-ALK – driven oncogenicity and renders IL-17 – producing immunophenotype to anaplastic large cell lymphoma * (2011) (16)
STK10 missense mutations associated with anti-apoptotic function. (2013) (15)
Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma (2019) (15)
Schedule-dependent synergism and antagonism between pemetrexed and paclitaxel in human carcinoma cell lines in vitro (2004) (15)
Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (2016) (15)
HLA Class I analysis provides insight into the genetic and epigenetic background of immune evasion in colorectal cancer with high microsatellite instability. (2021) (15)
Retroviral expression screening of oncogenes in natural killer cell leukemia. (2005) (15)
Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO) (2018) (15)
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells (2020) (15)
A Specific Role of Phosphatidylinositol 3–Kinase γ (2001) (14)
Mutations of N‐ras Oncogene in Myelodysplastic Syndromes and Lcukemias Detected by Polymerase Chain Reaction (1989) (14)
Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer (2015) (14)
Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in human solid tumors. (1987) (14)
Beta(2)-microglobulin identified as an apoptosis-inducing factor and its characterization. (1999) (14)
TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment (2021) (14)
Mutations in the Nucleolar Phosphoprotein, Nucleophosmin, Promote the Expression of the Oncogenic Transcription Factor MEF/ELF4 in Leukemia Cells and Potentiates Transformation* (2013) (14)
A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer (2017) (14)
Evidence for activation of Amh gene expression by steroidogenic factor 1 (2006) (14)
Epigenetic abnormalities in cardiac hypertrophy and heart failure (2008) (14)
Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia. (2018) (14)
Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia (2018) (13)
Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity (2018) (13)
Screening of genes responsible for differentiation of mouse mesenchymal stromal cells by DNA micro-array analysis of C3H10T1/2 and C3H10T1/2-derived cell lines. (2007) (13)
High‐throughput resequencing of target‐captured cDNA in cancer cells (2012) (13)
Extensive functional evaluation of exon 20 insertion mutations of EGFR. (2020) (12)
Isoform-dependent interaction of BRDG1 with Tec kinase. (2001) (12)
Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. (2020) (12)
Recurrent SPI 1 ( PU . 1 ) fusions in high-risk pediatric T cell acute lymphoblastic leukemia (2019) (11)
High‐throughput screening of genome fragments bound to differentially acetylated histones (2004) (11)
DNA micro-array analysis of myelodysplastic syndrome (2006) (11)
Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti–PD-1 Therapy (2022) (11)
Expression of the myeloperoxidase gene in AC133 positive leukemia cells relates to the prognosis of acute myeloid leukemia. (2006) (11)
Abstract 2821: Anti-tumor activity of ASP3026, – A novel and selective ALK inhibitor - (2011) (10)
Hemophagocytic syndrome associated with non‐hodgkin's lymphoma of B‐cell type (1994) (10)
Highly sensitive fusion detection using plasma cell‐free RNA in non‐small‐cell lung cancers (2021) (10)
A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination (2019) (10)
Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. (2018) (10)
miR-378 a-3 p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT 1 A (2015) (10)
Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met. (2008) (10)
Transforming activity of the lymphotoxin-beta receptor revealed by expression screening. (2005) (10)
Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts (2011) (9)
Cancer genomic medicine in Japan (2020) (9)
A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma (2020) (9)
Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter (2019) (9)
Transcriptional profile of genes induced in human atrial myocardium with pressure overload. (2004) (9)
Stratification of Acute Myeloid Leukemia Based on Gene Expression Profiles (2004) (9)
Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein: a novel in vitro model of the growth of acute ATL cells (2008) (9)
Presence of a genistein‐responsive inhibitory mechanism on interleukin‐1α‐induced NF‐κB activation (2001) (9)
[Acute myeloid leukemia with monosomy 7 accompanied by central diabetes insipidus]. (1997) (8)
Reciprocal expression of trefoil factor‐1 and thyroid transcription factor‐1 in lung adenocarcinomas (2020) (8)
Coordinate expression of the alpha and beta chains of human granulocyte-macrophage colony-stimulating factor receptor confers ligand-induced morphological transformation in mouse fibroblasts. (1993) (8)
Correction: Corrigendum: Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults (2016) (8)
Identification of a novel fusion gene HMGA2‐EGFR in glioblastoma (2015) (8)
Tec kinase stimulates cell survival in transfected Hek293T cells and is regulated by the anti-apoptotic growth factor IGF-I in human neutrophils. (2013) (8)
Mesenchymal tumours with RREB1–MRTFB fusion involving the mediastinum: extra‐glossal ectomesenchymal chondromyxoid tumours? (2020) (8)
Effects of Olmesartan, an Angiotensin II Receptor Blocker, on Mechanically-Modulated Genes in Cardiac Myocytes (2003) (7)
Stress signaling by Tec tyrosine kinase in the ischemic myocardium. (2010) (7)
Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus (2020) (7)
Nanostring-based screening for tyrosine kinase fusions in inflammatory myofibroblastic tumors (2020) (7)
Genomic profiling of multiple primary cancers including synchronous lung adenocarcinoma and bilateral malignant mesotheliomas: Identification of a novel BAP1 germline variant (2020) (7)
Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer (2021) (7)
mRAP, a sensitive method for determination of microRNA expression profiles. (2007) (6)
Identification of candidates for driver oncogenes in scirrhous‐type gastric cancer cell lines (2019) (6)
Schedule-dependent synergism and antagonism between pemetrexed and docetaxel in human lung cancer cell lines in vitro (2009) (6)
Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas. (2020) (6)
Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy (2021) (6)
Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes (2013) (6)
Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer (2019) (6)
HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma. (2022) (6)
Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution (2021) (6)
A prospective PCR – based screening for the EML 4-ALK oncogene in non-small cell lung cancer Running title : PCR – based screening for EML 4-ALK (2012) (5)
Development of an optimal protocol for molecular profiling of tumor cells in pleural effusions at single‐cell level (2021) (5)
KRAS mutations in uterine endometrium are associated with gravidity and parity (2020) (5)
Comprehensive molecular and clinicopathological profiling of desmoid tumours. (2021) (5)
Spontaneous Transformation from EGFR and ALK Wild-Type Lung Adenocarcinoma to Neuroendocrine Carcinoma. (2018) (5)
[ALK inhibitor]. (2011) (5)
Primary Cell Preparation of Human Renal Tubular Cells for Transcriptome Analysis (2004) (5)
Molecular analysis of the t(1;19)(q23;p13) translocation observed in adult leukemias. (1994) (5)
Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies (2022) (5)
Analysis of chromosome copy number in leukemic cells by different microarray platforms (2007) (5)
Additional file 3: Figure S2 (2013) (4)
Characterization of the large‐scale Japanese patient‐derived xenograft (J‐PDX) library (2021) (4)
Comprehensive molecular profiling of pulmonary pleomorphic carcinoma (2021) (4)
Second-generation ALK inhibitors. (2015) (4)
Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model (2022) (4)
C-CAT: The National Datacenter for Cancer Genomic Medicine in Japan (2022) (4)
Apoptosis-mediated regulation of recombinant human granulocyte colony-stimulating factor production by genetically engineered fibroblasts (1998) (4)
EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells (2020) (3)
Incidentally proven pulmonary "ALKoma". (2010) (3)
Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration (2022) (3)
Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 Activation (1999) (3)
Genomic and Clinical Characterization of Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia (2018) (3)
Increased Tyrosine-Phosphorylation of 55-kDa Proteins in -Actin/ Tec Transgenic Mice (1995) (3)
Identification of the transforming activity of Indian hedgehog by retroviral expression screening (2010) (3)
Dramatic response to entrectinib in a patient with malignant peripheral nerve sheath tumor harboring novel SNRNP70‐NTRK3 fusion gene (2022) (3)
Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte. (2010) (3)
High prevalence of MEF2D fusion in human B‐cell precursor acute lymphoblastic leukemia cell lines (2020) (3)
Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations. (2019) (3)
Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma. (2020) (3)
Presence of a genistein-responsive inhibitory mechanism on interleukin-1alpha-induced NF-kappaB activation. (2001) (2)
Analysis of a Mouse Model forEML4-ALK-Positive Lung Cancer. (2009) (2)
Scapular Angiomatoid Fibrous Histiocytoma with EWSR1-CREB1 Fusion in an Adult Patient (2021) (2)
A Japanese nationwide network for the diagnosis of EML4-ALK-positive lung cancer: A joint study of ALCAS and NEJ004. (2010) (2)
Identified as an Apoptosis-Inducing Factor and Its Characterization (1999) (2)
Primary Intracranial Spindle Cell Sarcoma, DICER1-Mutant, with MDM2 Amplification Diagnosed on the Basis of Extensive Molecular Profiling (2022) (2)
Genetic Testing Distinguishes Multiple Chondroid Chordomas with Neuraxial Bone Metastases from Multicentric Tumors (2020) (2)
Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia (2021) (2)
Abstract 1911: A common BIM polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer (2012) (2)
Gene Expression Profiles of CD133-positive Fractions Predict the Survival of Individuals with Acute Myeloid Leukemia. (2006) (2)
SY1. building the foundation for investigator-initiated clinical trial (2012) (2)
Spontaneous Transdifferentiation from Small Cell Lung Carcinoma to Squamous Cell Carcinoma. (2019) (2)
[Medical genomics of leukemia/lymphoma]. (2009) (1)
Secondary EML4-ALK-positive lung adenocarcinoma in a patient previously treated for acute lymphoblastic leukemia in childhood: a case report. (2014) (1)
Composite Clonal Analysis Reveals Transition of NSCLC Subtypes Through Accumulation of Gene Mutations: A Case Report (2022) (1)
Clinical Application of Next-generation Sequencing for the Diagnosis of Lung Squamous Cell Carcinoma: Is It Primary or Secondary? (2020) (1)
Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens (2023) (1)
Identification of Activated RRAS2 in Tongue Carcinoma Cell Line (2006) (1)
Outcome-Related Genome Loci in T-Cell Non-Hodgkin’s Lymphoma Identified by High-Resolution SNP-Typing Arrays. (2006) (1)
Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling (2022) (1)
Discovery and Clinical Application of a Novel Lung Cancer Oncogene, EML4-ALK. (2010) (1)
Exploration of predictive biomarkers for postoperative recurrence of stage II/III colorectal cancer using genomic sequencing (2022) (1)
- Tec: Tec protein-tyrosine kinase (vertebrates) (1995) (1)
The Genetic Landscape Of FPD/AML Revealed CDC25C Mutation As a Driver That Promotes Malignant Transformation (2013) (1)
The 9th International Symposium on Memory and Awareness in Anesthesia (MAA9) (2015) (1)
Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non–small Cell Lung Cancer PDX Models with Driver Genetic Alterations (2021) (1)
Increased tyrosine-phosphorylation of 55KDa proteins in beta-actin/Tec transgenic mice. (1995) (1)
[Novel EML4-ALK fusion oncogene in lung cancer]. (2009) (1)
[Discovery and clinical application of mutations in the cancer genome]. (2015) (1)
EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained By EBUS-TBNA (2010) (1)
Lung: non-small cell carcinoma with inv(2)(p21p23) (2011) (1)
Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers (2021) (1)
growth factors Reprogramming of human post-mitotic neutrophils into macrophages by (2013) (0)
Title Autocrine and / or paracrine growth of aggressive ATLL cells caused byHGF and c-Met (0)
Expression and Role of Macrophage Migration Inhibitory Factor in the Myocardium (2002) (0)
[The 42nd Scientific Meeting: Perspectives of Internal Medicine; Considerations to treatment and care of cancer by internists in the era of increasing cancer mortality; 2. Fruits of Basic Research on Cancer; 2) Clinical application of cancer genome analyses]. (2015) (0)
Abstract 4900: An ALK fusion gene regulates different signaling pathways in mortal versus immortalized normal human cells for cellular senescence and transformation (2020) (0)
Comprehensive mRNA-based screen for tyrosine kinase fusions and a de novo alternative transcription initiation site in soft tissue sarcomas. (2018) (0)
Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes (2013) (0)
Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions (2019) (0)
Comprehensive Genetic Analysis in Cases of Juvenile Myelomonocytic Leukemia for Prognostic Estimation (2016) (0)
Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. (2020) (0)
Fusion gene EML4-ALK. (2007) (0)
Circulating tumor DNA molecular profiling in rare cancer patients from the MASTER KEY Project. (2019) (0)
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis (2018) (0)
Pancreatic ductal carcinoma-specific genes identified by DNA microarray analysis with ductal cells (2003) (0)
[Cytoplasmic kinase inhibitors]. (2010) (0)
MicroSEC: Sequence error filtering pipeline for formalin-fixed and paraffin-embedded samples (2021) (0)
[Discovery of EML4-ALK, a new gene responsible for lung cancer, and the development of molecular targeted therapy]. (2010) (0)
Tumour specific cell death by cytosine deaminase under the control of A-fetoprotein enhancer/promoter unit (2000) (0)
[Cancer genome defined by the next generation sequencers]. (2011) (0)
Abstract 4967: Array-based genomic resequencing of acute myeloid leukemia (2011) (0)
[Epigenetics and hematological disorders]. (2006) (0)
Gene Expression Profiles with Signatures of Tumor Biology and Chemotherapy Sensitivity May Provide a Novel Approach to Maximize Response to Induction Therapy in Patients with Acute Myeloid Leukemia. (2008) (0)
Table of Contents (1994) (0)
Genome-Wide Screening of Histone Deacetylase-Targets in Cardiac Myocytes (Molecular Biology, Myocardium 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society) (2005) (0)
Biological protection mechanisms of radioprotectorsin mammalian cells. XIV. Effect of AET on DNA synthesis in mouse somatic cells. (1970) (0)
MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples (2021) (0)
Clinical diagnosis of a double primary sigmoid colon cancer and metastatic tumour using a gene‐targeted panel test: a case report (2020) (0)
Eml4-Alk and its Inhibitors: A New Paradigm in Cancer Treatment (2012) (0)
University of Groningen miR-378 a-3 p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT 1 (2017) (0)
GENO-27GENOMIC CHARACTERIZATION OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA REVEALS PREDOMINANT NONSYNONYMOUS SOMATIC MUTATIONS OF MYD88 AND PIM1 GENES (2015) (0)
Imaging , Diagnosis , Prognosis A Prospective PCR-Based Screening for the EML 4-ALK Oncogene in Non – Small Cell Lung Cancer (2012) (0)
ZNF384-Fusion Proteins Have High Affinity to EP300, Which Increases Their Transcriptional Activities (2018) (0)
Mesenchymal Stem Cells Self-Regulate Their Differentiation To Maintain the Bone Marrow Stromal System. (2004) (0)
DNA Microarray Analysis of GPI-Negative Hematopoietic Stem Cells in Paroxysmal Nocturnal Hemoglobinuria Patients. (2005) (0)
Circulating late‐stage erythrold progenitors in a patient with agnagenic myeloid metaplasia (1994) (0)
Practical screening system of oncogenic driver fusions in lung adenocarcinoma, using the NanoString nCounter. (2017) (0)
Ethical concerns on sharing genomic data including patients’ family members (2018) (0)
The CAncer Genomic Test Standardized Format : A Unified File Format to Summarize Genomic Aberrations (2022) (0)
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies (2020) (0)
Genetic diagnosis of pseudomyxoma peritonei originating from mucinous borderline tumor inside an ovarian teratoma (2022) (0)
Tee Protein-Tyrosine Kinase Is Involved in Interleukin-3 Signaling Pathway (2000) (0)
Abstract 256: Detection of METexon 14 skipping and fusions in non-small cell lung cancer by comprehensive genomic profiling using a dual targeted DNA/RNA panel (2023) (0)
EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells (2021) (0)
A new era of the Asian clinical research network: a report from the ATLAS international symposium. (2023) (0)
Tumor mutational burden measurement using comprehensive genomic profiling assay. (2022) (0)
Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan (2023) (0)
The pathogenic role of the BRCA2 c.7847C>T (p.Ser2616Phe) variant in breast and ovarian cancer predisposition. (2023) (0)
The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan. (2023) (0)
Cancer Genomic Medicine: Today and the Future (2022) (0)
Cells with stem‐like properties are associated with the development of HPV18‐positive cervical cancer (2022) (0)
High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer (2022) (0)
Molecular pathology quality control in Southeast Asia: Results of a Multiregional Quality Assurance Study from MASTER KEY Asia. (2023) (0)
Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis (2022) (0)
PD-1 Blockade Therapy Promotes Novel Infiltration of Tumor-Specific T-Cell Clonotypes (2021) (0)
[New molecular targeted EML4-ALK for lung cancer]. (2009) (0)
Potential application of dominant negative retinoic acid receptor genes for ex vivo expansion of hematopoietic stem cells (1999) (0)
TecKinaseAssociates withc-kit andIsTyrosine Phosphorylated andActivated following StemCell Factor Binding (1994) (0)
Human CD4+ T Cells Help CD8+ T Cells Proliferate Ex Vivo by Secreting Both IL-2/IL-21 and Upregulating IL-21R (2010) (0)
Abstract 3893: Whole-exome sequencing analysis of primary central nervous system lymphoma reveals recurrent MYD88 and PIM1 mutations (2015) (0)
Involvement of c-Src-Bcl-xL Pathway in Anti-apoptotic Effects of Endothelin in Rat Cultured Cardiac Myocytes (2002) (0)
Chromosomal Translocations in Lung Cancer (2015) (0)
Activating JAK3 Mutations in Transient Myeloproliferative Disorder and Acute Megakaryoblastic Leukemia Accompanying Down Syndrome. (2007) (0)
Lung : non-small cell carcinoma with inv ( 2 ) ( p 21 p 23 ) (2011) (0)
Author Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia (2022) (0)
An ALK-positive NSCLC patient with the G 1202 R mutation detected by next-generation sequencing (2016) (0)
[Lung cancer: progress in diagnosis and treatments. Topics: IV. Recent topics; 1. Driver mutations in non-small cell lung cancer]. (2014) (0)
Cancer Genomic Profiling of Gynecological Malignancies by Todai OncoPanel, a Twin DNA and RNA Panel (2021) (0)
Gene expression profiling of human myocardium with atrial fibrillation by DNA microarray analysis (2002) (0)
Abstract 921: High-throughput functional evaluation of variants of unknown significance inERBB2 (2018) (0)
Title Transforming somatic mutations of mammalian target of rapamycin kinasein human cancer (2019) (0)
L4-ALK Fusion Gene Assessment Using Metastatic Lymph e Samples Obtained by Endobronchial Ultrasound-Guided (2010) (0)
Biological protection mechanisms of radioprotectors in mammalian cells. 13. Effects of AET and serotonin on the DNA content of Ehrlich tumor cell nuclei. (1970) (0)
Presence of a genisteinâresponsive inhibitory mechanism on interleukinâ1Î±âinduced NFâÎºB activation (2001) (0)
DNA Microarray Analysis of Stage Progression Mechanism in Adult T-Cell Leukemia. (2004) (0)
Author response for "High prevalence of MEF2D fusion in human B‐cell precursor acute lymphoblastic leukemia cell lines" (2020) (0)
Reprogramming of human post-mitotic neutrophils into macrophages by growth factors Running head: Reprogramming of neutrophils into macrophages (2003) (0)
3014 Comprehensive analyses of oncogenic driver fusions using the NanoString nCounter in lung adenocarcinoma from Japanese never- and light-smokers (2015) (0)
M1624 Identification of Oncogene By Retroviral Expression Screening in Gallbladder Cancer (2008) (0)
Abstract 3394: Actionable fusion kinases in microsatellite instability-high colorectal cancers (2018) (0)
[Development of anti-cancer drug: past and future]. (2015) (0)
GENE-19. TARGETED SEQUENCING PANEL (TODAI ONCOPANEL) FOR VARIOUS TYPES OF BRAIN TUMORS (2019) (0)
[108th Scientific Meeting of the Japanese Society of Internal Medicine: panel discussion: 2. Discovery and clinical application of a novel oncogene in lung cancer]. (2011) (0)
A platform trial with a registry study for rare cancers: MASTER KEY project (2019) (0)
Discovery of the EML4-ALK Fusion Oncogene; an Effective Target in Lung Cancer (2012) (0)
[BAMP screening: a novel approach for the analysis of human leukemias]. (2003) (0)
5. The Future of Cancer Genomic Medicine (2020) (0)
Bruton’s Tyrosine Kinase Is Required For Lipopolysaccharide-induced Tumor Necrosis Factor (cid:2) Production (2003) (0)
Genetic diagnosis of pseudomyxoma peritonei originating from mucinous borderline tumor inside an ovarian teratoma (2022) (0)
EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in immortalized normal human cells (2020) (0)
Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4–ALK-rearranged non–small–cell lung cancer harbored coexisting EGFRmutation (2013) (0)
OJ-098 Weighted Distance Method : a Novel, Expression Profile-Based Prediction Algorithm for Atrial Fibrillation(Arrhythmia, Diagnosis/Pathophysiology/EPS 7 (A) : OJ12)(Oral Presentation (Japanese)) (2004) (0)
Novel Stratification Scheme for AML Based on a Large-Scale DNA Microarray Analysis of CD133-Positive Blasts. (2004) (0)
Cancer Therapy : Preclinical ParacrineReceptor Activation byMicroenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML 4-ALK Lung Cancer Cells (2012) (0)
Comprehensive genetic analysis of microsatellite instability-high colorectal cancers. (2018) (0)
[DNA chip analysis of hematological disorders]. (2001) (0)
Autophagosomal closure is mediated by the ESCRT machinery. (2017) (0)
[Other intracellular tyrosine kinases (including ALK)]. (2012) (0)
Tec Kinase Inhibits the Expression of IL-2 Receptor Alpha (CD25) in Human T-Lymphocyte. (2008) (0)
Abstract 2185: MicroSEC: Sequence error filter for formalin-fixed and paraffin-embedded samples (2022) (0)
Novel therapies targeting essential growth drivers (2016) (0)
Biological protection mechanisms of radioprotectors in mammalian cells. XV. Effects of AET and serotonin on DNA synthesis of Ehrlich tumor cells. (1970) (0)
Abstract 3683: Reciprocal expressions of TFF-1 and TTF-1 in lung adenocarcinomas (2018) (0)
BRAF mutations and hMLH1 promoter methylation status in non-familial colorectal carcinoma with microsatellite instability (2003) (0)
0686 ENDOTHELIAL CONSTITUTIVE NITRIC OXIDE SYNTHASE GENE TRANSFER INHIBITS CELLULAR PROLIFERATIVE ACTIVITY (1997) (0)
Abstract 516: High-throughput functional evaluation of variants of unknown significance inEGFR (2017) (0)
Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation. (2010) (0)
S2004 Identification of Transforming Activity of Indian Hedgehog By a Retroviral Expression Screening (2009) (0)
Identifications of Highly Aggressive Phenotype with SPI1 Overexpression in Pediatric T Cell Acute Lymphoblastic Leukemia/Lymphoma (2016) (0)
analysis with purified hematopoietic stem cell fraction specific genes by DNA microarray - Identification of myelodysplastic syndrome (2013) (0)
O-28 DNA microarray analysis ofmyelodysplastic syndromes with purified CD133-positive stem cell fractions (2005) (0)
[Maltipulication of osteoplastic sarcoma metastasizing to the lung]. (1970) (0)
Erratum to: Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts (2012) (0)
Cardioprotective effects of angiotensin II receptor blockade on the molecular responses induced by mechanical stress in cardiac myocytes (2002) (0)
DNA microarray analysis of the in vivo progression mechanism for heart failure in Dahl salt-sensitive rats (2002) (0)
Tokuda Akihiro Tomida Shinya Toyokuni Hitoshi Tsuda Shoichiro Tsugane Tatsuhiko Tsunoda Heiichiro Udono Koji Ueda Yoshimasa Uehara Hiroo Ueno Kazuo Umezawa Toshikazu Ushijima Toshihiko Wakabayashi Kenji Wakai Tetsuro Watabe (2016) (0)
Abstract LB-279: Cancer cDNA resequencing with an exon-capture system (2011) (0)
Abstract SY14-04: Discovery and clinical application of EML4-ALK oncogene in lung cancer (2010) (0)
Analysis of the Role of Pax6 Targeting miRNA During Mouse Retinal Development (2011) (0)
Multi-sample Full-length Transcriptome Analysis of 22 Breast Cancer Clinical Specimens with Long-Read Sequencing (2020) (0)
Targeting ALK Tyrosine Kinase in Lung Cancer (2012) (0)
Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL-Rearranged Acute Myeloid Leukemia (2018) (0)
Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia (2021) (0)
ALK-positive Lung Adenocarcinoma in a Patient Previously Treated for Acute Lymphoblastic Leukemia in Childhood : A Case Reportated for Acute Lymphoblastic Leukemia in Childhood : A Case Report (2018) (0)
Alterations in whole coding region (EXONS 2–11) of the p53 gene in gastric adenomas detected by genechip p53 assay (2003) (0)

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