Hiroyuki Osada
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Hiroyuki Osadachemistry Degrees
Chemistry
#3098
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#4086
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Organic Chemistry
#485
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#562
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Chemistry
Hiroyuki Osada's Degrees
- PhD Chemistry University of Tokyo
- Masters Chemistry University of Tokyo
- Bachelors Chemistry University of Tokyo
Why Is Hiroyuki Osada Influential?
(Suggest an Edit or Addition)Hiroyuki Osada's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation (2002) (688)
- Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in Osteoclastogenesis Mediated by Receptor Activator of NF-κB Ligand (RANKL)* (2000) (527)
- M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (2004) (493)
- Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. (2005) (224)
- Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis (2006) (195)
- Tryprostatin A, a specific and novel inhibitor of microtubule assembly. (1998) (183)
- Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase☆ (1997) (175)
- Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties. (1996) (167)
- Separation of proteins by charged ultrafiltration membranes (1988) (152)
- A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning. (2002) (144)
- Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes. (2000) (140)
- RK‐682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase (1995) (136)
- Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions. (2003) (133)
- Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines (2000) (132)
- The phosphorylation status and anti‐apoptotic activity of Bcl‐2 are regulated by ERK and protein phosphatase 2A on the mitochondria (2004) (127)
- Suppression of Apoptosis by Cyclophilin D via Stabilization of Hexokinase II Mitochondrial Binding in Cancer Cells* (2006) (127)
- Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a (1991) (126)
- The Multidrug Resistance-associated Protein (MRP) Subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae Is Important for the Tolerance to a Broad Range of Organic Anions* (1996) (125)
- Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages (2008) (124)
- The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I (2008) (116)
- Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition* (2009) (110)
- Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp. (1999) (109)
- Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus. (1995) (108)
- Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus. (1995) (106)
- Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp. (2002) (102)
- SPR imaging of photo-cross-linked small-molecule arrays on gold. (2006) (98)
- Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme (2015) (97)
- RECK negatively regulates matrix metalloproteinase-9 transcription. (2009) (96)
- Specific Activation of a c-Jun NH2-terminal Kinase Isoform and Induction of Neurite Outgrowth in PC-12 Cells by Staurosporine* (1997) (95)
- Reversal of breast cancer resistance protein–mediated drug resistance by tryprostatin A (2003) (95)
- Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics. (2005) (94)
- Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone (2008) (93)
- Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival (2016) (93)
- Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta (2009) (92)
- Novel Mammalian Cell Cycle Inhibitors, Spirotryprostatins A and B, Produced by Aspergillus fumigatus, Which Inhibit Mammalian Cell Cycle at G2/M Phase (1997) (92)
- Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides. (2017) (89)
- A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5. (2003) (89)
- Isolation and biological activity of a novel cytokine modulator, cytoxazone. (1998) (85)
- The Anticancer Natural Product Pironetin Selectively Targets Lys352 of α-Tubulin (2004) (85)
- Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. (1998) (85)
- Activation of p38 mitogen‐activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor (2000) (84)
- A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. (2010) (84)
- Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326. (2011) (84)
- Cobtorin target analysis reveals that pectin functions in the deposition of cellulose microfibrils in parallel with cortical microtubules. (2010) (82)
- Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages (2016) (82)
- Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups (2015) (81)
- Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp. (2001) (81)
- Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation. (2011) (80)
- Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. (2007) (80)
- Biotransformation of the Mycotoxin, Zearalenone, to a Non-estrogenic Compound by a Fungal Strain of Clonostachys sp. (2002) (80)
- Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion. (2003) (79)
- Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action. (2010) (78)
- Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity. (2005) (78)
- Morphobase, an encyclopedic cell morphology database, and its use for drug target identification. (2012) (78)
- Vipirinin, a Coumarin-based HIV-1 Vpr Inhibitor, Interacts with a Hydrophobic Region of VPR* (2011) (78)
- Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. (2013) (76)
- Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition. (2001) (73)
- Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. (2006) (73)
- Target identification of small molecules based on chemical biology approaches. (2013) (71)
- Asymmetric, stereocontrolled total synthesis of (+) and (−)-spirotryprostatin B via a diastereoselective azomethine ylide [1,3]-dipolar cycloaddition reaction (2002) (70)
- Reveromycin A, a new antibiotic which inhibits the mitogenic activity of epidermal growth factor. (1991) (70)
- Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins. (1998) (69)
- A novel mitochondrial DnaJ/Hsp40 family protein BIL2 promotes plant growth and resistance against environmental stress in brassinosteroid signaling (2013) (69)
- Identification of Cytochrome P450s Required for Fumitremorgin Biosynthesis in Aspergillus fumigatus (2009) (68)
- Cell cycle arrest and antitumor activity of pironetin and its derivatives. (1998) (67)
- Identification of Saccharomyces cerevisiae Isoleucyl-tRNA Synthetase as a Target of the G1-specific Inhibitor Reveromycin A* (2002) (67)
- Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites. (2002) (67)
- A new antibiotic, tautomycetin. (1989) (66)
- Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors. (1997) (66)
- In vitro reconstruction of tetronate RK-682 biosynthesis (2009) (65)
- Heparanase as a molecular target of cancer chemotherapy (2004) (64)
- Construction of a microbial natural product library for chemical biology studies. (2012) (64)
- Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays. (2010) (63)
- Functional Annotation of Chemical Libraries across Diverse Biological Processes (2017) (63)
- Amphidinolide h, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament. (2004) (63)
- Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-pyran derivative as the diene component in the Diels-Alder reaction. (2005) (63)
- Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. (2008) (63)
- Secretion of Heparanase Protein Is Regulated by Glycosylation in Human Tumor Cell Lines* (2004) (63)
- Total synthesis of (+)-epoxyquinols A and B. (2002) (63)
- Rapid screening method for inhibitors of protein kinase C. (1988) (62)
- Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin. (1999) (62)
- Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions (2014) (62)
- Biochemical Characterization of a Novel Indole Prenyltransferase from Streptomyces sp. SN-593 (2010) (61)
- Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120. (2011) (61)
- Enhancement and Selective Production of Phoslactomycin B, a Protein Phosphatase IIa Inhibitor, through Identification and Engineering of the Corresponding Biosynthetic Gene Cluster* (2003) (61)
- Enzymatic Generation of the Antimetabolite γ,γ-Dichloroaminobutyrate by NRPS and Mononuclear Iron Halogenase Action in a Streptomycete (2006) (61)
- Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. (2012) (60)
- Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana (2012) (60)
- Identification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin (2006) (59)
- Essential Role of p38 Mitogen-activated Protein Kinase in Contact Hypersensitivity* (2002) (59)
- Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D. (1992) (58)
- Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases (2012) (57)
- Kerriamycin B inhibits protein SUMOylation (2009) (57)
- RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. (2005) (57)
- Synthesis of (+)-vinblastine and its analogues. (2007) (55)
- A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis. (2015) (54)
- Affinity-based target identification for bioactive small molecules (2014) (54)
- Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor. (2002) (53)
- Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions. (2006) (53)
- Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus (2017) (52)
- Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis (1999) (52)
- Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba. (2012) (51)
- The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons (1995) (50)
- Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells. (1997) (50)
- The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua. (2010) (49)
- Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. (1992) (46)
- p62 functions as a p38 MAP kinase regulator. (2000) (46)
- A new biological role of sangivamycin; inhibition of protein kinases. (1989) (45)
- Involvement of disulfide bond formation in the activation of heparanase. (2007) (45)
- Activation of MST/Krs and c-Jun N-terminal Kinases by Different Signaling Pathways during Cytotrienin A-induced Apoptosis* (2000) (45)
- A Novel Adenine Nucleotide Translocase Inhibitor, MT-21, Induces Cytochrome c Release by a Mitochondrial Permeability Transition-independent Mechanism* (2002) (44)
- Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling. (2011) (44)
- Immunolocalization of p38 MAP kinase in mouse brain (2000) (44)
- Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues. (2000) (44)
- Dephosphorylation of Bcl‐2 by protein phosphatase 2A results in apoptosis resistance (2004) (44)
- Structure-based design of a selective heparanase inhibitor as an antimetastatic agent. (2004) (44)
- MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria. (2000) (44)
- ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007 (2005) (43)
- Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives. (2006) (43)
- Lucilactaene, a new cell cycle inhibitor in p53-transfected cancer cells, produced by a Fusarium sp. (2001) (43)
- Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition. (2001) (43)
- Reveromycin A Inhibits Osteolytic Bone Metastasis of Small-Cell Lung Cancer Cells, SBC-5, through an Antiosteoclastic Activity (2005) (43)
- Expression of heparanase in human tumor cell lines and human head and neck tumors. (2003) (43)
- Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity. (2004) (42)
- 4‐Isoavenaciolide covalently binds and inhibits VHR, a dual‐specificity phosphatase (2002) (42)
- The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug. (2008) (42)
- Phoslactomycin targets cysteine‐269 of the protein phosphatase 2A catalytic subunit in cells (2005) (41)
- Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis* (2008) (41)
- Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210. (1997) (41)
- Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity. (2002) (41)
- Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment (2010) (41)
- Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties. (1992) (41)
- Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum* (2012) (41)
- Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. (2017) (41)
- The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain. (2003) (41)
- p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression. (2005) (40)
- Introduction of New Tools for Chemical Biology Research on Microbial Metabolites (2010) (40)
- Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei. (2002) (40)
- Brasilicardin A, a natural immunosuppressant, targets amino Acid transport system L. (2006) (40)
- Asymmetric total synthesis of pseurotin A. (2003) (39)
- Kaurene Diterpene Induces Apoptosis in Human Leukemia Cells Partly through a Caspase-8-Dependent Pathway (2004) (39)
- Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro. (2000) (38)
- Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity. (1991) (38)
- A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity. (1990) (38)
- Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells. (1999) (38)
- Novel heparan sulfate mimetic compounds as antitumor agents. (2004) (38)
- New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation. (1998) (37)
- A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). II. Isolation, physico-chemical properties and structure. (1990) (37)
- A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity. (1992) (37)
- Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis (2009) (37)
- Stevastelins, a novel group of immunosuppressants, inhibit dual-specificity protein phosphatases. (1997) (36)
- Control of the Stereochemical Course of [4+2] Cycloaddition during trans-Decalin Formation by Fsa2-Family Enzymes. (2018) (36)
- A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. (2010) (35)
- ATM blocks tunicamycin‐induced endoplasmic reticulum stress (2009) (35)
- A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein (2015) (35)
- Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin. (2006) (35)
- Achievement of over 1.4 V photovoltage in a dye-sensitized solar cell by the application of a silyl-anchor coumarin dye (2016) (35)
- Iejimalides Show Anti-Osteoclast Activity via V-ATPase Inhibition (2006) (35)
- An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae (2015) (34)
- Mechanism of action and selective toxicity of ascamycin, a nucleoside antibiotic (1985) (34)
- Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution[S] (2011) (34)
- New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components. (1998) (34)
- Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library. (2010) (33)
- Boron‐Based Inhibitors of Acyl Protein Thioesterases 1 and 2 (2013) (33)
- Osteoclast‐targeting small molecules for the treatment of neoplastic bone metastases (2009) (33)
- [Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata]. (2003) (33)
- Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin. (1988) (33)
- Fumagillin suppresses HIV‐1 infection of macrophages through the inhibition of Vpr activity (2006) (32)
- Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy. (2012) (32)
- Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II (2008) (31)
- New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006 (2016) (31)
- Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf‐1 activation (2008) (31)
- Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b. (2010) (31)
- Acetophthalidin, a novel inhibitor of mammalian cell cycle, produced by a fungus isolated from a sea sediment. (1996) (31)
- RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities. (1995) (31)
- Synthesis of pironetin and related analogs: studies on structure-activity relationships as tubulin assembly inhibitors. (2000) (31)
- Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells (1997) (30)
- Genetic Safeguard against Mycotoxin Cyclopiazonic Acid Production in Aspergillus oryzae (2011) (30)
- Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods. (2015) (30)
- Terpeptin, a novel mammalian cell cycle inhibitor, produced by Aspergillus terreus 95F-1 (1997) (30)
- Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field. (2016) (29)
- Asymmetric synthesis of RK-682 and its analogs, and evaluation of their protein phosphatase inhibitory activities (1996) (29)
- Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus (2013) (29)
- Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1. (2007) (29)
- Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array. (2010) (29)
- Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells. (2007) (29)
- First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry. (2005) (29)
- High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism. (2016) (28)
- Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus (2011) (28)
- The structure of enopeptins A and B, novel depsipeptide antibiotics (1991) (28)
- Effects of tryprostatin derivatives on microtubule assembly in vitro and in situ. (1998) (28)
- RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening (2014) (27)
- Extracellular phosphorylation of membrane protein modifies theta burst-induced long-term potentiation in CA1 neurons of guinea-pig hippocampal slices (1995) (27)
- A Point Mutation in ftmD Blocks the Fumitremorgin Biosynthetic Pathway in Aspergillus fumigatus Strain Af293 (2013) (27)
- Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. (2016) (27)
- Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols (2008) (26)
- Systematic isolation of microbial metabolites for natural products depository (NPDepo) (2011) (26)
- Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain (2016) (26)
- Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells. (2002) (26)
- Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells. (2005) (26)
- Chemical modification of reveromycin A and its biological activities. (2002) (26)
- Bioprobes for investigating mammalian cell cycle control. (1998) (26)
- Inhibition of human telomerase activity by alterperylenol. (1998) (25)
- Liposidomycin B inhibits in vitro formation of polyprenyl (pyro)phosphate N-acetylglucosamine, an intermediate in glycoconjugate biosynthesis. (1997) (25)
- A practical total synthesis of both enantiomers of epoxyquinols A and B (2002) (25)
- Formation and Dissociation of the BSS1 Protein Complex Regulates Plant Development via Brassinosteroid Signaling[OPEN] (2015) (25)
- Identification of a Molecular Target of a Novel Fungal Metabolite, Pyrrolizilactone, by Phenotypic Profiling Systems (2013) (25)
- Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013. (2016) (25)
- Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces. (2016) (25)
- Proteomic profiling reveals that collismycin A is an iron chelator (2016) (24)
- Brassinosteroid-related transcription factor BIL1/BZR1 increases plant resistance to insect feeding (2014) (24)
- Different reaction modes for the oxidative dimerization of epoxyquinols and epoxyquinones. Importance of intermolecular hydrogen-bonding. (2004) (24)
- A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure. (1992) (24)
- Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus (2006) (23)
- Novel non-peptide inhibitors targeting death receptor-mediated apoptosis. (2003) (23)
- Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs (2008) (23)
- Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9. (2012) (23)
- [Special Issue: Fact Databases and Freewares] RIKEN Natural Products Encyclopedia (RIKEN NPEdia),a Chemical Database of RIKEN Natural Products Depository (RIKEN NPDepo) (2006) (23)
- Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors. (2013) (23)
- Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-κB Signaling by Crosslinking TAK1 (2008) (23)
- Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis. (2003) (23)
- RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2 (2004) (22)
- Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005. (2015) (22)
- Protein tyrosine phosphatase 1B inhibitory activity of 24‐norursane triterpenes isolated from Weigela subsessilis (2010) (22)
- Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells. (2012) (22)
- Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells (2016) (22)
- High-throughput screening identifies small molecule inhibitors of molecular chaperones. (2012) (22)
- Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593. (2017) (22)
- Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity. (2011) (22)
- Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. (2009) (22)
- CRM646-A and -B, novel fungal metabolites that inhibit heparinase. (2000) (22)
- Epoxycyclohexenone Inhibits Fas-mediated Apoptosis by Blocking Activation of Pro-caspase-8 in the Death-inducing Signaling Complex* (2003) (22)
- Cleavable linker for photo-cross-linked small-molecule affinity matrix. (2010) (21)
- Stereocomplementary Chemoenzymatic Pictet–Spengler Reactions for Formation of Rare Azepino-indole Frameworks: Discovery of Antimalarial Compounds (2019) (21)
- KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue. (2010) (21)
- Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. (2019) (21)
- Cytotrienin A, a translation inhibitor that induces ectodomain shedding of TNF receptor 1 via activation of ERK and p38 MAP kinase. (2011) (21)
- Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host (2017) (21)
- Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase. (2008) (21)
- Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic. (1998) (21)
- Pentaminomycins A and B, Hydroxyarginine-Containing Cyclic Pentapeptides from Streptomyces sp. RK88-1441. (2018) (21)
- Indomethacin Induction of Metamorphosis from the Asexual Stage to Sexual Stage in the Moon Jellyfish, Aurelia aurita (2012) (21)
- Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation (2017) (21)
- Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives. (2005) (21)
- Development of a Vaccinia H1‐Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate‐Mimicking Core Structure (2011) (20)
- Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2-[(4-methylthiopyridin-2-yl)methylsulfinyl]benzimidazole (2000) (20)
- Identification of small molecule inhibitors of p27Kip1 ubiquitination by high‐throughput screening (2013) (20)
- Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc05040b (2018) (20)
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- A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine). (1992) (20)
- Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds from Streptomyces reveromyceticus SN-593 (2011) (20)
- Exip, a splicing variant of p38α, participates in interleukin‐1 receptor proximal complex and downregulates NF‐κB pathway (2004) (20)
- Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells. (2006) (20)
- Biosynthesis of phoslactomycins: cyclohexanecarboxylic acid as the starter unit (2003) (20)
- Small molecules that target phosphorylation dependent protein-protein interaction. (2016) (19)
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- Terpendole E and its Derivative Inhibit STLC‐ and GSK‐1‐Resistant Eg5 (2014) (19)
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- Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp. (1999) (17)
- Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus. (2005) (17)
- Fascinating Bioactive Compounds from Actinomycetes (1995) (17)
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- Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms. (2019) (16)
- Nocardamin Production by Streptomyces avermitilis (2009) (16)
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- A small molecule that induces reactive oxygen species via cellular glutathione depletion. (2014) (15)
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- Synthetic studies on reveromycin A: Stereoselective synthesis of the spiroketal system (1996) (15)
- TU-572, a Potent and Selective CD45 Inhibitor, Suppresses IgE-Mediated Anaphylaxis and Murine Contact Hypersensitivity Reactions (2001) (15)
- Structure-Function Analyses of Cytochrome P450revI Involved in Reveromycin A Biosynthesis and Evaluation of the Biological Activity of Its Substrate, Reveromycin T* (2014) (15)
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- Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647 (2019) (15)
- Synthesis and biological activities of reveromycin A and spirofungin A derivatives. (2008) (15)
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- Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume (2019) (14)
- Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. (2006) (14)
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- Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition (2019) (14)
- New pyrrolobenzodiazepine antibiotics, RK-1441A and B. I. Biological properties. (1990) (14)
- Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells. (2009) (14)
- Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit* (2015) (14)
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- Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058 (2017) (14)
- The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin. (2004) (14)
- Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp. (1998) (14)
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- Spectomycin B 1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E 2 (2013) (14)
- Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation. (1989) (14)
- A new cyclic lipopeptide antibiotic, enamidonin. (1995) (13)
- Actinomycetes, How Fascinating Microorganisms (1998) (13)
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- Vicenistatin induces early endosome-derived vacuole formation in mammalian cells (2016) (13)
- Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation (2008) (13)
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- Structure of RK-397, a new oxo pentaene antibiotic. (1993) (13)
- Genome-wide maps of mono- and di-nucleosomes of Aspergillus fumigatus (2009) (13)
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- Improvement of transformation efficiency by strategic circumvention of restriction barriers in Streptomyces griseus. (2011) (13)
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- Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation (2022) (12)
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- Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166. (2001) (12)
- Protein Targeting with Small Molecules (2009) (12)
- Allantopyrone A activates Keap1–Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death (2016) (12)
- Molecular Interaction between Cyclophilin D and Adenine Nucleotide Translocase in Cytochrome c Release (2003) (12)
- BPG3 is a novel chloroplast protein that involves the greening of leaves and related to brassinosteroid signaling (2014) (12)
- Molecular cloning and characterization of a broad substrate terpenoid oxidoreductase from Artemisia annua. (2010) (12)
- A new trichostatin derivative, trichostatin RK, from Streptomyces sp. RK98-A74. (2001) (12)
- Exip, a splicing variant of p38alpha, participates in interleukin-1 receptor proximal complex and downregulates NF-kappaB pathway. (2004) (12)
- Identification and Characterization of an Inhibitor of Trichothecene 3-O-Acetyltransferase, TRI101, by the Chemical Array Approach (2013) (12)
- Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity (2015) (12)
- Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics. (2013) (12)
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- Violaceols Function as Actin Inhibitors Inducing Cell Shape Elongation in Fibroblast Cells (2012) (11)
- Identification of Saccharomyces cerevisiae Ribosomal Protein L3 as a Target of Curvularol, a G1-Specific Inhibitor of Mammalian Cells (2006) (11)
- Synthesis and Biological Activity of Aminoacyl Analogs of Ascamycin (1988) (11)
- Phenotypic screening meets natural products in drug discovery† (2017) (11)
- Direct measurement of oscillatory generation of superoxide anions by single phagocytes (1996) (11)
- Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057. (2014) (11)
- Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi (2014) (11)
- Chemical fragment arrays for rapid druggability assessment. (2016) (11)
- Respinomycins A1, A2, B, C and D, a novel group of anthracycline antibiotics. II. Physico-chemical properties and structure elucidation. (1993) (11)
- Exploring the chemical space of microbial natural products. (2009) (11)
- β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593 (2020) (11)
- Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. (2016) (11)
- Absolute configuration of epiderstatin, a new glutarimide antibiotic produced by Streptomyces pulveraceus. (1992) (11)
- Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters (2016) (10)
- Isoxazole-4-carboxylic Acid as a Metabolite of Streptomyces sp. and Its Herbicidal Activity (1991) (10)
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- Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations (2020) (10)
- Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons (2021) (10)
- An Overview on the Diversity of Actinomycete Metabolites (2001) (10)
- SYNTHESES AND BIOACTIVITIES OF ACETOPHTHALIDIN AND ITS DERIVATIVES (1998) (10)
- Identification and structure–activity relationship of purine derivatives as novel MTH1 inhibitors (2017) (10)
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- Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments (2019) (10)
- Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway (2020) (10)
- 3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from Desmodium sambuense-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF-TrkB Signaling Pathways. (2019) (10)
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- New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure. (1990) (10)
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- Nordihydroguaiaretic Acid, of a New Family of Microtubule-stabilizing Agents, Shows Effects Differentiated from Paclitaxel (2003) (9)
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- A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell–accelerated fibroblast migration (2019) (9)
- Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast (2016) (9)
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- Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. II. Isolation, physico-chemical properties and structure elucidation. (1996) (9)
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- Green-odour compounds have antifungal activity against the rice blast fungus Magnaporthe oryzae (2011) (8)
- Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A. (2006) (8)
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- Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation (2021) (8)
- Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. I. Taxonomy of the producing organism, fermentation and biological activity. (1996) (8)
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- Novel Triene‐Ansamycins, Cytotrienins A and B, Inducing Apoptosis on Human Leukemia HL‐60 Cells. (1997) (8)
- A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening. (2021) (8)
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- Isolation and characterization of the gene encoding an aminopeptidase involved in the selective toxicity of ascamycin toward Xanthomonas campestris pv. citri. (1996) (8)
- Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae (2021) (8)
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- Isolation and characterization of a new antibiotic, malolactomycin A. (1993) (7)
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- Alkyldihydropyrones, new polyketides synthesized by a type III polyketide synthase from Streptomyces reveromyceticus (2014) (7)
- Proteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGE. (2018) (7)
- Identification of a small‐molecule ligand of β‐arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells (2018) (7)
- Synthesis and Characterization of a Novel Protein Tyrosine Phosphatase Inhibitor, 2-(Cyclobutylamino)- N- (2-Furylmethyl)-2-Thioxoacetamide (2005) (7)
- Acetophthalidin, a Novel Inhibitor of Mammalian Cell Cycle, Produced by a Fungus Isolated from a Sea Sediment (1996) (7)
- ECH, an Epoxycyclohexenone Derivative That Specifically Inhibits Fas Ligand-Dependent Apoptosis in CTL-Mediated Cytotoxicity1 (2004) (7)
- Epiderstatin induces the flat reversion of NRK cells transformed by temperature-sensitive Rous sarcoma virus. (1992) (7)
- Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling. (2021) (7)
- Induction of Nectriapyrone Biosynthesis in the Rice Blast Fungus Pyricularia oryzae by Disturbance of the Two‐Component Signal Transduction System (2019) (7)
- Identification of a Chemical Modulator of EZH2-mediated Silencing by Cell-based High-throughput Screening Assay. (2019) (7)
- Aturanosides A and B, Glycosylated Anthraquinones with Antiangiogenic Activity from a Soil-Derived Streptomyces Species. (2018) (7)
- Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. (2013) (7)
- Synthesis and biological activity of nucleoside antibiotics, ascamycin and its amino acid analogs. (1985) (7)
- Renal Abnormalities in Mice Caused by Insufficiency of p38α (2003) (7)
- Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684 (2017) (7)
- Identification of matrix metalloproteinase inhibitors by chemical arrays (2015) (7)
- A facile and effective screening method for p21WAF1 promoter activators from microbial metabolites. (2001) (7)
- Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene (2020) (6)
- Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana (2016) (6)
- Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells. (2009) (6)
- Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor (2015) (6)
- Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium. (2018) (6)
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- The Japanese Society for Chemical Biology (2006) (6)
- Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana (2020) (6)
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- One-pot Synthesis of Novel α-Aminophosphonate Derivatives Containing a Pyrazole Moiety (2012) (6)
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- β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593 (2019) (6)
- Brassinosteroids regulate vacuolar morphology in root meristem cells of Arabidopsis thaliana (2018) (6)
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- A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test (2017) (5)
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- Occurrence of an ascamycin dealanylating enzyme, Xc-aminopeptidase, in mammalian cell membranes and susceptibility to ascamycin. (1986) (5)
- Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae. (2005) (5)
- Reveromycin A inhibits antigen receptor-mediated antigen presentation by B lymphoma cells via its effect on intracellular trafficking of the antigen. (2002) (5)
- Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors. (2019) (5)
- Molecular Basis for Two Stereoselective Diels–Alderases that Produce Decalin Skeletons (2021) (5)
- Zealpeptaibolin, an 11-mer cytotoxic peptaibol group with 3 Aib-Pro motifs isolated from Trichoderma sp. RK10-F026 (2021) (5)
- In Silico Investigation of a HIV‐1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti‐HIV Drug Design (2014) (5)
- Erratum: Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics (Angewandte Chemie - International Edition (2005) 44 (3559-3562)) (2005) (5)
- RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis (2015) (5)
- Alteration of tooth movement by reveromycin A in osteoprotegerin-deficient mice. (2020) (4)
- Aromatic butenolides produced by a soil ascomycete Auxarthron sp. KCB15F070 derived from a volcanic island (2019) (4)
- YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001 (2019) (4)
- Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection (2022) (4)
- Control of the Stereochemical Course of [4+2] Cycloaddition during trans -Decalin Formation by Fsa2-Family Enzymes (2018) (4)
- Proteomics-based target identification of natural products affecting cancer metabolism (2021) (4)
- Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase. (2021) (4)
- Two new triterpenoids from the roots of Pinus densiflora (2017) (4)
- Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical–Genetic Interactions (2021) (4)
- The Insulin Receptor: A Potential Target of Amarogentin Isolated from Gentiana rigescens Franch That Induces Neurogenesis in PC12 Cells (2021) (4)
- Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth. (2021) (4)
- Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007 (2019) (4)
- Production of a protein A--lymphotoxin hybrid protein for cancer-targeted therapy. (1990) (4)
- Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete (2020) (4)
- Sesquiterpene glucosides from Shenzhou honey peach fruit showed the anti-aging activity in the evaluation system using yeasts (2017) (4)
- Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum. (2018) (4)
- A cell-based screening to detect inhibitors of BRAF signaling pathway (2009) (4)
- New Types of Liposidomycins That Inhibit Bacterial Peptidoglycan Synthesis and are Produced by Streptomyces. Part 2. Isolation and Structure Elucidation. (1998) (4)
- [Biosynthesis of natural products from microbes]. (2007) (3)
- Structure—Activity Relationships of Epolactaene Derivatives: Structural Requirements for Inhibition of Hsp60 Chaperone Activity. (2004) (3)
- Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists. (2019) (3)
- Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy–Refractory Cancer Growth (2021) (3)
- Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels–Alderases (2022) (3)
- Anti-Angiogenesis Effects Induced by Octaminomycins A and B against HUVECs. (2018) (3)
- Productivity and bioactivity of enokipodins A–D of Flammulina rossica and Flammulina velutipes (2020) (3)
- Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism. (2021) (3)
- Hot springs and cool natural products. (2008) (3)
- New Types of Liposidomycins Which Inhibit Bacterial Peptidoglycan Synthesis Produced by Streptomyces. (1998) (3)
- Epoxyquinol A (I), a Highly Functionalized Pentaketide Dimer with Antiangiogenic Activity Isolated from Fungal Metabolites (2002) (3)
- Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94. (2021) (3)
- An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s (2019) (3)
- Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system. (1989) (3)
- Polarization of osteoclasts on dental implant materials is similar to that observed on bone (2014) (3)
- Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma (2020) (3)
- Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins. (2020) (3)
- Synthesis and Biological Properties of New Phosmidosine Analogs Having an N-Acylsulfamate Linkage (2006) (3)
- RK‐95113, a New Angiogenesis Inhibitor Produced by Aspergillus fumigatus. (2007) (3)
- Hypoxia-Adapted CML Cells Are More Primitive Population and Are Eradicated by Glyoxalase-1 Inhibitors. (2009) (3)
- Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078 (2015) (3)
- Small-Molecule Microarrays as Tools for Facilitating Chemical Genomics : Recent Advances (2006) (3)
- Detection of oxygen addition peaks for terpendole E and related indole–diterpene alkaloids in a positive-mode ESI-MS (2014) (3)
- Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74 (2013) (3)
- Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity (2021) (2)
- Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods (2020) (2)
- Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator. (2021) (2)
- Studies on inhibitory mechanism of microtubule inhibitors (2001) (2)
- Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs. (2018) (2)
- Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents. (2004) (2)
- Dissection of two modes of IE1 sub-nuclear localization in baculovirus-infected cells. (2015) (2)
- Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2. (2000) (2)
- Microbial Fraction Library: A Screening Source for Drug Discovery (2019) (2)
- The education system for chemical biology in Japanese universities. (2006) (2)
- Privileged biorenewable secologanin-based diversity-oriented synthesis for pseudo-natural alkaloids: uncovering novel neuroprotective and antimalarial frameworks. (2021) (2)
- Construction of a potato fraction library for the investigation of functional secondary metabolites (2019) (2)
- [Forward and reverse chemical genetics utilizing naturally occurring bioprobes]. (2005) (2)
- 2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture. (2021) (2)
- Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor. (2022) (2)
- Isolation and Biological Properties of a New Cell Cycle Inhibitor, Curvularol, Isolated from Curvularia sp. RK97-F166. (2001) (2)
- Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus. (2021) (2)
- Asymmetric, Stereocontrolled Total Synthesis of (+)- and (-)-Spirotryprostatin B via a Diastereoselective Azomethine Ylide [1,3]-Dipolar Cycloaddition Reaction. (2002) (2)
- Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects? (2021) (2)
- Structure‐Activity Relationships of Terpendole E and Its Natural Derivatives. (2017) (2)
- Molecular chaperones as drug targets. (2013) (2)
- Structure and biological activity of ascamycin, a new nucleoside antibiotic. (1984) (2)
- Hamaguchi, T., Masuda, A., Morino, T. & Osada, H. Stevastelins, a novel group of immunosuppressants, inhibit dual-specificity protein phosphatases. Chem. Biol. 4, 279-286 (1997) (2)
- Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6. (2021) (2)
- RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441 (2016) (2)
- Special issue: Nucleoside antibiotics, polyoxin and beyond (2019) (2)
- Terpeptin, a Novel Mammalian Cell Cycle Inhibitor, Produced by Aspergillus terreus 95F‐1. (1997) (2)
- CRM646-A, a Fungal Metabolite, Induces Nucleus Condensation by Increasing Ca2+ Levels in Rat 3Y1 Fibroblast Cells (2019) (2)
- A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells (2020) (2)
- Editorial: [Hot Topic: Molecular Chaperones as Drug Targets] (2012) (1)
- Fraction Libraries and Genetics as Tools for Natural Product Research: Focus on Decalin-Containing Compounds (2019) (1)
- A Hetero Pauson—Khand Reaction of Ketenimines: A New Synthetic Method for γ-Exomethylene-α,β-unsaturated γ-Lactams. (2010) (1)
- Glaziovianin A, a New Isoflavone, from the Leaves of Ateleia Glaziovianna and Its Cytotoxic Activity Against Human Cancer Cells. (2007) (1)
- Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth. (2021) (1)
- Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility. (2014) (1)
- β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet-Spengler Reactions to Tryptoline-type Alkaloids. (2022) (1)
- Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities (2022) (1)
- Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells. (2020) (1)
- Osteoclast Inhibitors for Bone Fracture Healing in Mice with High-Turnover Osteoporosis (2020) (1)
- Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. (2023) (1)
- [Development of novel angiogenesis inhibitors targeting VEGF (vascular endothelial growth factor) for cancer chemotherapy]. (2004) (1)
- N‐(3,4‐dimethoxyphenethyl)‐6‐methyl‐2,3,4,9‐tetrahydro‐1H‐carbazol‐1‐amine inhibits bladder cancer progression by suppressing YAP1/TAZ (2022) (1)
- Inhibitory action of epiderstatin on EGF-stimulated growth of mouse epidermal. BALB/MK cells without direct effect on protein kinase activities. (1994) (1)
- Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition (2019) (1)
- Errata: Functional annotation of chemical libraries across diverse biological processes. (2017) (1)
- Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells (2022) (1)
- Synthesis and biological properties of stable phosmidosine analogs. (2003) (1)
- Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications (2009) (1)
- New Abscisic Acid Derivatives Revealed Adequate Regulation of Stomatal, Transcriptional, and Developmental Responses to Conquer Drought. (2021) (1)
- Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress (2020) (1)
- Local administration of ReveromycinA ointment suppressed alveolar bone loss in mice. (2021) (1)
- Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry. (2020) (1)
- Lipopolysaccharide defective mutant of Escherichia coli with decreased sensitivity to colicin E2 (1985) (1)
- Screening of Bioactive Microbial Products (Molecular Probes) which Regulate Mammalian Cell Functions (1994) (1)
- Stress meets development in p38 MAP kinase (2002) (1)
- A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escherichia coli as an index. (2009) (1)
- Synthesis of Lucilactaene (2005) (1)
- Reduction of Arylcarbonyl Using Zinc Dust in Acetic Acid. (1995) (1)
- Abstract A243: Identification of a target for collismycin A, a cytotoxic microbial product, by proteomic profiling. (2013) (1)
- Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium (2018) (1)
- Sparoxomycins A1 and A2, New Inducers of the Flat Reversion of NRK Cells Transformed by Temperature Sensitive Rous Sarcoma Virus. Part 2. Isolation, Physico-Chemical Properties and Structure Elucidation. (1996) (1)
- Cytotrienin A, a Novel Apoptosis Inducer in Human Leukemia HL‐60 Cells. (1997) (1)
- Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock (2021) (1)
- Synthesis of the Src SH2 domain and its application in bioassays for mirror-image screening (2017) (1)
- Discovery and mechanism of action of nonpeptide neuritogenic compounds (1998) (1)
- Eighth Korea–Japan Chemical Biology symposium: chemical biology notes from a small island (2016) (1)
- Correction to "Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea". (2018) (1)
- N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647 (2021) (1)
- Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana (2021) (1)
- The chemistry/biology interface. (2012) (1)
- PC-766B' and PC-766b, 16-membered macrolide angiogenesis inhibitors produced by Nocardia sp. RK97-56 (2002) (1)
- Roles of Osteoclasts in Leukemic Cells (2008) (1)
- [Development of new antitumor reagents which block the cell cycle progression]. (1997) (1)
- CmLec4, a lectin from the fungus Cordyceps militaris, controls host infection and fruiting body formation. (2022) (1)
- [Cytoskeletal system]. (2012) (1)
- Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo. (2022) (1)
- Syntheses and Bioactivities of Acetophthalidin and Its Derivatives. (1999) (1)
- Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae (2021) (1)
- First Asymmetric Total Synthesis of Synerazol (I), an Antifungal Antibiotic, and Determination of Its Absolute Stereochemistry. (2005) (0)
- Recent Developments and Advances in Chemical Arrays (2009) (0)
- Search for immunomodulators based on antigen presentation (2017) (0)
- Data on Small Molecules and their Target Proteins (2009) (0)
- 296 Antitumor activity of NPD723, a novel potent cell differentiationinducing agent in leukemic cells (2010) (0)
- Asymmetric Synthesis of RK-682 and Its Analogues, and Evaluation of Their Protein Phosphatase Inhibitory Activities. (1997) (0)
- Corrigendum to "Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress" [Heliyon 6 (10) (October 2020) e05200]. (2021) (0)
- 26 NPD926, a small molecule inducer of reactive oxygen species, kills cancer cells via glutathione depletion (2014) (0)
- Protective Effects of Barley and Oats on Gastric Stress Ulcer Induced by Water Immersion in Rats (1998) (0)
- Crystal structure of TAS1 KS domain that conducts cyclization step of mycotoxin tenuazonic acid (2017) (0)
- Small molecule inhibitors for polo box domain dependent recognition (2007) (0)
- Antibiotics as regulators of animal cells. Natural compounds regulating proliferation of animal cells. Microbial metabolites regulating signal transduction of growth factors. (1989) (0)
- Genetic safeguard against mycotoxin production and cyclopiazonic acid biosynthesis in Aspergillus oryzae (2014) (0)
- Co-crystal structure of NRPS adenylation protein CytC1 with ATP from streptomyces (2013) (0)
- Structure of a New Macrolactam isolated from a Microbial Fraction Library (2010) (0)
- Pharmacokinetics and acetylcholinesterase(AChE) inhibitory effects of distigmine in streptozotocin-induced diabetic rat. (2012) (0)
- Estrogen and progesterone receptors as molecular targets for anticancer drug (2003) (0)
- rc SH 2 domain and its application in bioassays for mirror-image screening † (2017) (0)
- Abstract B199: Identification of novel tubulin polymerization inhibitors by proteomic profiling. (2011) (0)
- 90 POSTER Inhibition of VEGF (vascular endothelial growth factor)/VEGF receptor system activation and in vivo tumor-induced angiogenesis by an anti-angiogenic small molecule epoxyquinol B (2006) (0)
- Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics (2016) (0)
- Total Synthesis of Epoxyquinols A (I), B (II), and C (III) and Epoxytwinol A (IV) and the Reactivity of a 2H‐Pyran Derivative as the Diene Component in the Diels—Alder Reaction. (2005) (0)
- P-65 BIOMIMETIC OXIDATIVE DIMERIZATION FORMING EPOXYTWINOL A AND ITS COMPUTATIONAL ANALYSIS (2006) (0)
- Identification of artesunate as a selective inhibitor of cancer stemness through the mitochondrial dysfunction (2016) (0)
- Synthesis of (+)-Vinblastine (2008) (0)
- Development of Agrochemicals and Chemical Biology (2009) (0)
- Elucidation of indole-diterpene mycotoxin biosynthetic pathways and identification of terpendole E as a key biosynthetic intermediate (2014) (0)
- Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR 2 , EGFR , FGFR (2008) (0)
- [Novel angiogenesis inhibitors for molecular target therapy of cancer]. (2004) (0)
- The VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) Inhibitor Isolated from Gastrodia elata (2002) (0)
- A Target Identification System Based on MorphoBase, ChemProteoBase, and Photo‐Cross‐Linking Beads (2014) (0)
- Enantio‐ and Diastereoselective Total Synthesis of (+)‐Panepophenanthrin (I), a Ubiquitin‐Activating Enzyme Inhibitor, and Biological Properties of Its New Derivatives. (2007) (0)
- Sparoxomycins Al and A 2 , NewInducers of the Flat Reversion of NRKCells Transformed by Temperature Sensitive Rons Sarcoma Virus I . Taxonomy of the Producing Organism , Fermentation and Biological Activity (2006) (0)
- Human Casein Kinase 1 isoform delta apo (kinase domain) (2016) (0)
- P-335 SYNTHESIS OF RK-682 ENAMIDE DERIVATIVES AS NOVEL DUAL-SPECIFICITY PROTEIN PHOSPHATASE INHIBITORS (2006) (0)
- An Acidic Milieu Created In Myeloma-Osteoclast Interaction Enhances Tumor Growth, but Triggers Anti-Myeloma Activity of Reveromycin A, a Novel Anti-Resorptive Agent (2010) (0)
- Identification of Protein–Small Molecule Interactions by Chemical Array (2012) (0)
- Small-Molecule Microarrays as Tools for Facilitating Chemical Genomics: Recent Advances (2006) (0)
- Corrigendum: Detection of Cytochrome P450 Substrates by Using a Small‐Molecule Droplet Array on an NADH‐Immobilized Solid Surface (0)
- 522 POSTER Selective action of reveromycin A, a novel anti-resorptive agent, on osteoclasts (2006) (0)
- Green-odour compounds have antifungal activity against the rice blast fungus Magnaporthe oryzae (2011) (0)
- Crystal structure of mouse glyoxalase I complexed with methyl-gerfelin (2008) (0)
- Biosynthesis study of reveromycin : Aiming at a therapeutic agent to osteoclast related diseases (2015) (0)
- Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-Thiol Conjugation. (2008) (0)
- 273 High-Throughput Screening to Identify Small Molecule Inhibitors of P27Kip1 Ubiquitination (2012) (0)
- New substance with antitumor effect / anti-inflammatory effect (2002) (0)
- Abstract C105: Development and utilization of a cell morphology database, MorphoBase, for drug target identification. (2013) (0)
- A Practical Total Synthesis of Both Enantiomers of Epoxyquinols A (I) and B (II). (2003) (0)
- Concise Enantio‐ and Diastereoselective Total Syntheses of Fumagillol, RK‐805, FR65814, Ovalicin, and 5‐Demethylovalicin. (2006) (0)
- Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels–Alderases (2022) (0)
- Crystal structure of bleomycin-binding protein from Streptoalloteichus hindustanus complexed with bleomycin derivative (2009) (0)
- Application of the Luminescence Syncytium Induction Assay to Identify Chemical Compounds That Inhibit Bovine Leukemia Virus Replication (2022) (0)
- Identification of a novel family of benzimidazole species-selective Complex I inhibitors as potential anthelmintics (2022) (0)
- Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host (2017) (0)
- IP397Fluorescence Imaging of the Effects of Cyclophilin D on MitochondrialDysfunction Single Mitochondrion Imaging of Internal Membrane Structure (2014) (0)
- CHAPTER 5. Small Molecule Inhibitors of E3 Ubiquitin Ligases (2020) (0)
- RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity (2022) (0)
- 6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone (2021) (0)
- New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. (2022) (0)
- Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics (2020) (0)
- Chembiomolecular Science (2013) (0)
- Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells. (2023) (0)
- 85 POSTER Inhibition of tumor cell invasion by a heparanase inhibitor and expression of a dominant negative mutant of heparanase (2006) (0)
- β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593 (2019) (0)
- Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments (2019) (0)
- Remembering Professor Kiyoshi Isono (August 16, 1931–April 23, 2022) (2022) (0)
- Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058. (2023) (0)
- Formation and Dissociation of the BSS1 Protein Complex Regulates Plant Development via Brassinosteroid SignalingOPEN (2015) (0)
- A novel mitochondrial DnaJ/Hsp40 family protein BIL2 promotes plant growth and resistance against environmental stress in brassinosteroid signaling (2013) (0)
- Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent. (2023) (0)
- Two-dimensional electrophoresis-cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compounds. (2022) (0)
- Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete (2020) (0)
- CRM646‐A and ‐B, Novel Fungal Metabolites that Inhibit Heparinase. (2000) (0)
- Nanotubes in HIV-1 Spread in Macrophages Potential Role of the Formation of Tunneling (2016) (0)
- Regioselective Synthesis of Benzotriazoles (2011) (0)
- Synthesis of Reveromycin A Derivatives and its Biological Activities (2003) (0)
- Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide (2018) (0)
- Co-crystal structure of NRPS adenylation protein CytC1 with D-valine and AMP from streptomyces (2013) (0)
- A new gentiopicroside derivative improves cognitive deficits of AD mice via activation of Wnt signaling pathway and regulation of gut microbiota homeostasis. (2023) (0)
- Identification of Scytalone Dehydratase Inhibitors Effective against Melanin Biosynthesis Dehydratase Inhibitor-Resistant Pyricularia oryzae. (2022) (0)
- Crystal structure of Arabidopsis DWARF14‐LIKE2 (DLK2) reveals a distinct substrate binding pocket architecture (2022) (0)
- 2P-160 The role of Cyclophilin D in t-BuOOH induced cell death : its involvement in mitochondrial ATP supply(Cell biology,The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
- Small Molecule Biomediator Which Enhances the Production of Secondary Metabolites in Streptomyces: β-Carbonoline (BR-1) Enhances the Production of Reveromycin (2021) (0)
- Errata: Functional annotation of chemical libraries across diverse biological processes. (2017) (0)
- Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation (2017) (0)
- ILV/VI-1 Chemical biology using bioprobes for elucidating cellular function(Molecular Mode of Action on Natural Products and Drugs/Chemical Biology and Related Areas) (2006) (0)
- 3P177 How are the helix 12 in α- and β-tubulin subunit involved in kinesin motility? (2004) (0)
- P-480 PHOTO-CROSS-LINKED SMALL-MOLECULE AFFINITY MATRIX FOR FACILITATING CHEMICAL GENETICS (2006) (0)
- Synthesis and Characterization of a Potent and Selective Protein Tyrosine Phosphatase Inhibitor, 2‐[(4‐Methylthiopyridin‐2‐yl)methylsulfinyl]benzimidazole. (2001) (0)
- Phosphorylation of Bcl-xL by polo-like kinase 1 results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis (2007) (0)
- Crystal Structure of Human Pirin in complex with Triphenyl Compound (2010) (0)
- Microbial Secondary Metabolites Regulating the Animal Cell Proliferation and Differentiation. (1991) (0)
- A Gap Phase-Specific Inhibitor of the Mammalian Cell Cycle from Streptomyces sp. ZF10 (1994) (0)
- Synthesis of Pironetin and Related Analogues: Studies on Structure—Activity Relationships as Tubulin Assembly Inhibitors. (2000) (0)
- P-15 Photo-Cross-Linking of Small Molecule for Facilitating Forward and Reverse Chemical Genetics : Application for Small Molecule Microarrays and Small Molecule Affinity Beads (2005) (0)
- 39 POSTER A heparan sulfate mimetic compound Kl-105 inhibits the invasion and migration of HT1080 cells (2006) (0)
- Abstract B131: Chemical array screen identifies a novel MMP inhibitor NPDK-18 that suppresses tumor cell migration (2015) (0)
- Glyoxalase-I Is a Potential Therapeutic Target for Chronic Myelogenous Leukemia Cells That Have Acquired Drug Resistance through Adaptation to Hypoxia. (2007) (0)
- Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative (2016) (0)
- The 7th Japan-Korea chemical biology symposium: chemical biology of natural bioactive molecules. (2014) (0)
- Subject Index Vol. 126, 2001 (2001) (0)
- The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I (2007) (0)
- [Construction of natural products library and its usage for drug discovery]. (2009) (0)
- Synthesis (+)-Cytotrienin A (2009) (0)
- 36. Screening of brassinosteroid signaling mutants from FOX lines (2013) (0)
- Measurement of ATPase Activity of Valosin-containing Protein/p97. (2020) (0)
- Abstract A166: A small molecule inhibitor of Pirin that suppresses tumor cell migration (2009) (0)
- Bioprobes for Investigating Mammalian Cell Cycle Control (1999) (0)
- Co-crystal structure of NRPS adenylation protein CytC1 with aminobutyric acid and AMP from streptomyces (2013) (0)
- Syntheses of Fumagillol, RK-805, and FR65814 (2006) (0)
- Symposium on Interdisciplinary Researches in Okayama (2012) (0)
- 2P217 Cyclophilin D promotes cell death induced by t-BuOOH(Cell biological problems-adhesion, motility, cytoskeleton, signaling, and membrane,Poster Presentations) (2007) (0)
- Procede d'observation d'interaction (2005) (0)
- NEW SPLICING VARIANT OF MAP KINASE p38α (2001) (0)
- Screening of Antibiotics Using Mammalian Cells (1992) (0)
- Abstract C157: Identification of a novel DNA topoisomerase II inhibitor by proteomic profiling (2009) (0)
- 2P210 Detection of mitochondrial membrane permeability transition in intact cells(Cell biological problems-adhesion, motility, cytoskeleton, signaling, and membrane,Poster Presentations) (2007) (0)
- Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine (2019) (0)
- P-179 ABSOLUTE STEREOCHEMISTRY AND MOLECULAR TARGET OF ANTITUMOR MACROLIDES, IEJIMALIDES (2006) (0)
- Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44 (2018) (0)
- Phenylboronic Ester-Activated Aryl Iodide-Selective Buchwald–Hartwig-Type Amination toward Bioactivity Assay (2022) (0)
- Basic research of the regulation mechanisms of trichothecene production for reduction of the mycotoxin contamination (2014) (0)
- 39. Analysis of brassinosteroid signaling mutant bpg4 (2014) (0)
- [Small molecule inhibitors of phosphorylation specific peptidyl prolyl cis-trans isomerase Pin1]. (2012) (0)
- Mechanistic analysis of ERCC-1-XPF degradation induced by a novel NER inhibitor (2016) (0)
- Target pathway analysis of an antitumor compound JBIR-140 by a global screen for drug sensitivity genes (2017) (0)
- Factumycin and Its New Derivative RK‐1009 Enhance Threonine‐phosphorylation of a 60‐kDa Protein in Streptomyces griseus. (1999) (0)
- Identification of compounds that augment the lectin-sensitivity of Chinese Hamster Ovary cells. (2012) (0)
- Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A (2016) (0)
- Natural Products Synthesis Determination by Asymmetric Total Synthesis of the Absolute Configuration of Lucilactaene , a Cell-Cycle Inhibitor in p 53-Transfected Cancer Cells * * (2005) (0)
- Absolute Configuration of Reveromycin A, an Inhibitor of the Signal Transduction of Epidermal Growth Factor. (1995) (0)
- Exploitation of Anticancer Compounds from Marine Microbes (1997) (0)
- Crystal Structure of Cytochrome P450revI (2014) (0)
- [Cell cycle]. (2012) (0)
- Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene (2020) (0)
- Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae. (2021) (0)
- Discovery of an Acinar Morphogenesis Inhibitor Based on Fungal Metabolites (2012) (0)
- 1P-020 Crystal structure of glyoxalase I in complex with methyl-gerfelin(The 46th Annual Meeting of the Biophysical Society of Japan) (2008) (0)
- Biosynthesis of mycotoxin tenuazonic acid by novel type of fungal PKS/NRPS hybrid enzyme (2016) (0)
- 2P243 The role of cyclophilin D on persistence of mitochondrial membrane potential (2004) (0)
- Recently, we isolated epiderstatin1 '2) which inhibits the mitogenic activity induced by epidermal growth factor (EGF) in the culture fluid of Streptomyces pulveraceus subsp. epiderstagenes. Actiketal, a new member (2006) (0)
- 1P020 Crystal structure of NRPS A domain from Streptomyces(Proteins-structure and structure-function relationship,Oral Presentations) (2007) (0)
- Determination of the Absolute Configuration of Lucilactaene, a Cell‐Cycle Inhibitor in p53‐Transfected Cancer Cells, by Asymmetric Total Synthesis. (2005) (0)
- Cell Proliferation and Differentiation (2017) (0)
- [Chemical biology and novel molecular-targeted agents in cancer therapy]. (2015) (0)
- Intramolecular [2 + 2 + 2] Cycloaddition of Bis(propargylphenyl)carbodiimides: Synthesis of L‐Shaped π‐Extended Compounds with Pyrrolo[1,2‐a][1,8]naphthyridine Corner Units. (2013) (0)
- Crystal Structure Analysis of human LYPLAL1 (2011) (0)
- Activation of fungal secondary metabolism by disturbance of the two-component signal transduction system and identification of the nectriapyrone biosynthetic gene cluster (2016) (0)
- Contents list. (2016) (0)
- Exploiting diverse chemical collections to uncover novel antifungals (2021) (0)
- Epoxytwinol A, a Novel Unique Angiogenesis Inhibitor with C2 Symmetry, Produced by a Fungus (2005) (0)
- P-538 TOTAL SYNTHESIS OF PANEPOPHENANTHRIN AND BIOLOGICAL ACTIVITIES OF ITS DERIVATIVES (2006) (0)
- 355 Identification of an inhibitor for melanoma cell migration through the inhibition of Pirin (2010) (0)
- Ketosynthase domain in tenuazonic acid synthetase 1 (TAS1). (2020) (0)
- [Mode of action and molecular target of ECH, a specific inhibitor of death receptor-dependent apoptosis]. (2004) (0)
- Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents. (2020) (0)
- Synthetic Studies on Reveromycin A: Stereoselective Synthesis of the Spiroketal System. (1996) (0)
- 1P397 Fluorescence Imaging of the Effects of Cyclophilin D on Mitochondrial Dysfunction(15. Cellular signal transduction,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
- Development of anti-malaria compounds that interact with intracellular metal ions as targets (2017) (0)
- Glyoxalase-I Inhibition Eliminates Hypoxia-Adapted CML Cells Resistant to Imatinib, Dasatinib, and INNO-406 (2008) (0)
- Contents Vol. 126, 2001 (2001) (0)
- 34 Synthesis and Biological Evaluation of 6,6-Spiroketal Natural Products (2007) (0)
- Substance rkb-3564 having angiogenesis inhibitory action (2002) (0)
- Sparoxomycins A1 (I) and A2 (II), New Inducers of the Flat Reversion of NRK Cells Transformed by Temperature Sensitive Rous Sarcoma Virus. Part 1. Taxonomy of the Producing Organism, Fermentation and Biological Activity. (1997) (0)
- 1stIOF-ESCEO Pre-Clinical Symposium (2011) (0)
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What Schools Are Affiliated With Hiroyuki Osada?
Hiroyuki Osada is affiliated with the following schools: